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Conserved domains on  [gi|21357349|ref|NP_648767|]
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uncharacterized protein Dmel_CG7275 [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13236732)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly, contains a C-terminal Sof1-like domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sof1 pfam04158
Sof1-like domain; Sof1 is essential for cell growth and is a component of the nucleolar rRNA ...
 354-441 5.28e-39

Sof1-like domain; Sof1 is essential for cell growth and is a component of the nucleolar rRNA processing machinery.


:

Pssm-ID: 427753  Cd Length: 87  Bit Score: 135.70  E-value: 5.28e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349   354 ANASEKLGVIRPRERVNFNYQEALKQKYAAHPQIKRIARHRQVPRHVLNAQKKMRTVKEKEQVKEANVRKHTKKsKKVPY 433
Cdd:pfam04158   1 ANASEKLGVLSPRERAALEYNEALKEKYKHMPEIRRIARHRHVPKAIYKAQKIKREMLEARKRKEENRRKHSKP-GSVPR 79


                  ....*...
gi 21357349   434 VSEKKKHV 441
Cdd:pfam04158  80 KPERKKHV 87
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 62-353 2.97e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 140.16  E-value: 2.97e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349  62 LSGHRDGVSCFGKHPKQlSTLATGAYDGEVRIWDLANRISSRNFVAHDGFVRGIAYTQNGGRIFTVGDDKTIKVWKAEAP 141
Cdd:cd00200   5 LKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349 142 EV----GEDEVPVNTILskfglhgISHNRRdnKFATCGE--VCAIWDERHNDPLKTLKWGVDTLHTISYNPVETsILACC 215
Cdd:cd00200  84 ECvrtlTGHTSYVSSVA-------FSPDGR--ILSSSSRdkTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASS 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349 216 ASDRSIILYDQREAQPLRkvVLTMKS---NKLAWNPMEAfNFTVANEDCNLYTFDTRKLQTpLKVHFDHVSAVTDVDYSP 292
Cdd:cd00200 154 SQDGTIKLWDLRTGKCVA--TLTGHTgevNSVAFSPDGE-KLLSSSSDGTIKLWDLSTGKC-LGTLRGHENGVNSVAFSP 229

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21357349 293 TGKEFVSASYDKTIRIYNAHH-SHSRDIY-HTKRmqhVVCVAWSLDNRYVFSGSDEMNVRMWK 353
Cdd:cd00200 230 DGYLLASGSEDGTIRVWDLRTgECVQTLSgHTNS---VTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
Sof1 pfam04158
Sof1-like domain; Sof1 is essential for cell growth and is a component of the nucleolar rRNA ...
 354-441 5.28e-39

Sof1-like domain; Sof1 is essential for cell growth and is a component of the nucleolar rRNA processing machinery.


Pssm-ID: 427753  Cd Length: 87  Bit Score: 135.70  E-value: 5.28e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349   354 ANASEKLGVIRPRERVNFNYQEALKQKYAAHPQIKRIARHRQVPRHVLNAQKKMRTVKEKEQVKEANVRKHTKKsKKVPY 433
Cdd:pfam04158   1 ANASEKLGVLSPRERAALEYNEALKEKYKHMPEIRRIARHRHVPKAIYKAQKIKREMLEARKRKEENRRKHSKP-GSVPR 79


                  ....*...
gi 21357349   434 VSEKKKHV 441
Cdd:pfam04158  80 KPERKKHV 87
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 62-353 2.97e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.16  E-value: 2.97e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349  62 LSGHRDGVSCFGKHPKQlSTLATGAYDGEVRIWDLANRISSRNFVAHDGFVRGIAYTQNGGRIFTVGDDKTIKVWKAEAP 141
Cdd:cd00200   5 LKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349 142 EV----GEDEVPVNTILskfglhgISHNRRdnKFATCGE--VCAIWDERHNDPLKTLKWGVDTLHTISYNPVETsILACC 215
Cdd:cd00200  84 ECvrtlTGHTSYVSSVA-------FSPDGR--ILSSSSRdkTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASS 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349 216 ASDRSIILYDQREAQPLRkvVLTMKS---NKLAWNPMEAfNFTVANEDCNLYTFDTRKLQTpLKVHFDHVSAVTDVDYSP 292
Cdd:cd00200 154 SQDGTIKLWDLRTGKCVA--TLTGHTgevNSVAFSPDGE-KLLSSSSDGTIKLWDLSTGKC-LGTLRGHENGVNSVAFSP 229

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21357349 293 TGKEFVSASYDKTIRIYNAHH-SHSRDIY-HTKRmqhVVCVAWSLDNRYVFSGSDEMNVRMWK 353
Cdd:cd00200 230 DGYLLASGSEDGTIRVWDLRTgECVQTLSgHTNS---VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
62-355 1.13e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.42  E-value: 1.13e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349  62 LSGHRDGVSCFGKHPKQlSTLATGAYDGEVRIWDLANRISSRNFVAHDGFVRGIAYTQNGGRIFTVGDDKTIKVWKAEAP 141
Cdd:COG2319 116 LTGHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349 142 EvgedevPVNTIL-SKFGLHGISHNRRDNKFATCGE--VCAIWDERHNDPLKTLKWGVDTLHTISYNPvETSILACCASD 218
Cdd:COG2319 195 K------LLRTLTgHTGAVRSVAFSPDGKLLASGSAdgTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSAD 267

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349 219 RSIILYDQREAQPLRkvVLTMKS---NKLAWNPMEAFnFTVANEDCNLYTFDTRKLQtPLKVHFDHVSAVTDVDYSPTGK 295
Cdd:COG2319 268 GTVRLWDLATGELLR--TLTGHSggvNSVAFSPDGKL-LASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSVAFSPDGK 343

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21357349 296 EFVSASYDKTIRIYNAHHSHSRDIY--HTKRmqhVVCVAWSLDNRYVFSGSDEMNVRMWKAN 355
Cdd:COG2319 344 TLASGSDDGTVRLWDLATGELLRTLtgHTGA---VTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 273-310 6.21e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 6.21e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 21357349    273 TPLKVHFDHVSAVTDVDYSPTGKEFVSASYDKTIRIYN 310
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
273-310 4.94e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 4.94e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 21357349   273 TPLKVHFDHVSAVTDVDYSPTGKEFVSASYDKTIRIYN 310
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
Sof1 pfam04158
Sof1-like domain; Sof1 is essential for cell growth and is a component of the nucleolar rRNA ...
 354-441 5.28e-39

Sof1-like domain; Sof1 is essential for cell growth and is a component of the nucleolar rRNA processing machinery.


Pssm-ID: 427753  Cd Length: 87  Bit Score: 135.70  E-value: 5.28e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349   354 ANASEKLGVIRPRERVNFNYQEALKQKYAAHPQIKRIARHRQVPRHVLNAQKKMRTVKEKEQVKEANVRKHTKKsKKVPY 433
Cdd:pfam04158   1 ANASEKLGVLSPRERAALEYNEALKEKYKHMPEIRRIARHRHVPKAIYKAQKIKREMLEARKRKEENRRKHSKP-GSVPR 79


                  ....*...
gi 21357349   434 VSEKKKHV 441
Cdd:pfam04158  80 KPERKKHV 87
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 62-353 2.97e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.16  E-value: 2.97e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349  62 LSGHRDGVSCFGKHPKQlSTLATGAYDGEVRIWDLANRISSRNFVAHDGFVRGIAYTQNGGRIFTVGDDKTIKVWKAEAP 141
Cdd:cd00200   5 LKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349 142 EV----GEDEVPVNTILskfglhgISHNRRdnKFATCGE--VCAIWDERHNDPLKTLKWGVDTLHTISYNPVETsILACC 215
Cdd:cd00200  84 ECvrtlTGHTSYVSSVA-------FSPDGR--ILSSSSRdkTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASS 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349 216 ASDRSIILYDQREAQPLRkvVLTMKS---NKLAWNPMEAfNFTVANEDCNLYTFDTRKLQTpLKVHFDHVSAVTDVDYSP 292
Cdd:cd00200 154 SQDGTIKLWDLRTGKCVA--TLTGHTgevNSVAFSPDGE-KLLSSSSDGTIKLWDLSTGKC-LGTLRGHENGVNSVAFSP 229

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21357349 293 TGKEFVSASYDKTIRIYNAHH-SHSRDIY-HTKRmqhVVCVAWSLDNRYVFSGSDEMNVRMWK 353
Cdd:cd00200 230 DGYLLASGSEDGTIRVWDLRTgECVQTLSgHTNS---VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
62-355 1.13e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.42  E-value: 1.13e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349  62 LSGHRDGVSCFGKHPKQlSTLATGAYDGEVRIWDLANRISSRNFVAHDGFVRGIAYTQNGGRIFTVGDDKTIKVWKAEAP 141
Cdd:COG2319 116 LTGHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349 142 EvgedevPVNTIL-SKFGLHGISHNRRDNKFATCGE--VCAIWDERHNDPLKTLKWGVDTLHTISYNPvETSILACCASD 218
Cdd:COG2319 195 K------LLRTLTgHTGAVRSVAFSPDGKLLASGSAdgTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSAD 267

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349 219 RSIILYDQREAQPLRkvVLTMKS---NKLAWNPMEAFnFTVANEDCNLYTFDTRKLQtPLKVHFDHVSAVTDVDYSPTGK 295
Cdd:COG2319 268 GTVRLWDLATGELLR--TLTGHSggvNSVAFSPDGKL-LASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSVAFSPDGK 343

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21357349 296 EFVSASYDKTIRIYNAHHSHSRDIY--HTKRmqhVVCVAWSLDNRYVFSGSDEMNVRMWKAN 355
Cdd:COG2319 344 TLASGSDDGTVRLWDLATGELLRTLtgHTGA---VTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
62-364 2.43e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.25  E-value: 2.43e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349  62 LSGHRDGVSCFGKHPkQLSTLATGAYDGEVRIWDLANRISSRNFVAHDGFVRGIAYTQNGGRIFTVGDDKTIKVWKAEAP 141
Cdd:COG2319  74 LLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349 142 EV----GEDEVPVNTIlskfglhGISHNRRdnKFATCGEVCAI--WDERHNDPLKTLKWGVDTLHTISYNPvETSILACC 215
Cdd:COG2319 153 KLlrtlTGHSGAVTSV-------AFSPDGK--LLASGSDDGTVrlWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASG 222

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349 216 ASDRSIILYDQREAQPLRkvVLTMKSNK---LAWNPmeafN---FTVANEDCNLYTFD--TRKLQTPLKVHFDHVSAVTd 287
Cdd:COG2319 223 SADGTVRLWDLATGKLLR--TLTGHSGSvrsVAFSP----DgrlLASGSADGTVRLWDlaTGELLRTLTGHSGGVNSVA- 295

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21357349 288 vdYSPTGKEFVSASYDKTIRIYNAHHSHSRDIY--HTKRmqhVVCVAWSLDNRYVFSGSDEMNVRMWKANASEKLGVIR 364
Cdd:COG2319 296 --FSPDGKLLASGSDDGTVRLWDLATGKLLRTLtgHTGA---VRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 101-364 2.32e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.11  E-value: 2.32e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349 101 SSRNFVAHDGFVRGIAYTQNGGRIFTVGDDKTIKVWKAEAPEVGED----EVPVNTILSkfglhgISHnrrDNKFATCGE 176
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTlkghTGPVRDVAA------SAD---GTYLASGSS 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349 177 --VCAIWDERHNDPLKTLKWGVDTLHTISYNPvETSILACCASDRSIILYDQREAQPLRkvvlTMKS-----NKLAWNPM 249
Cdd:cd00200  72 dkTIRLWDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLT----TLRGhtdwvNSVAFSPD 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349 250 EAFNFTVANeDCNLYTFDTRKLQtPLKVHFDHVSAVTDVDYSPTGKEFVSASYDKTIRIYNAHHSHSRDIY--HTKRmqh 327
Cdd:cd00200 147 GTFVASSSQ-DGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrgHENG--- 221

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 21357349 328 VVCVAWSLDNRYVFSGSDEMNVRMWKANASEKLGVIR 364
Cdd:cd00200 222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS 258
WD40 COG2319
WD40 repeat [General function prediction only];
79-364 3.30e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.76  E-value: 3.30e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349  79 LSTLATGAYDGEVRIWDLANRISSRNFVAHDGFVRGIAYTQNGGRIFTVGDDKTIKVWKAEAPEVGEDEV----PVNTIl 154
Cdd:COG2319  48 GARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTghtgAVRSV- 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349 155 skfglhGISHNRRdnKFATCGE---VcAIWDERHNDPLKTLKWGVDTLHTISYNPVETsILACCASDRSIILYDQREAQP 231
Cdd:COG2319 127 ------AFSPDGK--TLASGSAdgtV-RLWDLATGKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKL 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357349 232 LRK----------VVLTMKSNKLAwnpmeafnftVANEDCN--LYTFDTRKLQTPLKvhfDHVSAVTDVDYSPTGKEFVS 299
Cdd:COG2319 197 LRTltghtgavrsVAFSPDGKLLA----------SGSADGTvrLWDLATGKLLRTLT---GHSGSVRSVAFSPDGRLLAS 263

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21357349 300 ASYDKTIRIYNAHHSHSRDIY--HTKRmqhVVCVAWSLDNRYVFSGSDEMNVRMWKANASEKLGVIR 364
Cdd:COG2319 264 GSADGTVRLWDLATGELLRTLtgHSGG---VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 327
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 273-310 6.21e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 6.21e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 21357349    273 TPLKVHFDHVSAVTDVDYSPTGKEFVSASYDKTIRIYN 310
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
273-310 4.94e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 4.94e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 21357349   273 TPLKVHFDHVSAVTDVDYSPTGKEFVSASYDKTIRIYN 310
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 103-137 2.58e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 2.58e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 21357349    103 RNFVAHDGFVRGIAYTQNGGRIFTVGDDKTIKVWK 137
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
103-136 1.30e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.30e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 21357349   103 RNFVAHDGFVRGIAYTQNGGRIFTVGDDKTIKVW 136
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
58-95 2.94e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.94e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 21357349    58 FVCNLSGHRDGVSCFGKHPKQlSTLATGAYDGEVRIWD 95
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 59-95 4.93e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 4.93e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 21357349     59 VCNLSGHRDGVSCFGKHPkQLSTLATGAYDGEVRIWD 95
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 321-353 4.75e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 4.75e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 21357349    321 HTKRmqhVVCVAWSLDNRYVFSGSDEMNVRMWK 353
Cdd:smart00320  11 HTGP---VTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
321-352 8.13e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 8.13e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 21357349   321 HTKRmqhVVCVAWSLDNRYVFSGSDEMNVRMW 352
Cdd:pfam00400  10 HTGS---VTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 COG2319
WD40 repeat [General function prediction only];
62-98 8.61e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 38.35  E-value: 8.61e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 21357349  62 LSGHRDGVSCFGKHPKQlSTLATGAYDGEVRIWDLAN 98
Cdd:COG2319 368 LTGHTGAVTSVAFSPDG-RTLASGSADGTVRLWDLAT 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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