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Conserved domains on  [gi|24662626|ref|NP_648456|]
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scylla, isoform A [Drosophila melanogaster]

Protein Classification

RTP801_C domain-containing protein( domain architecture ID 10544696)

RTP801_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RTP801_C pfam07809
RTP801 C-terminal region; The members of this family are sequences similar to the C-terminal ...
 139-252 3.50e-58

RTP801 C-terminal region; The members of this family are sequences similar to the C-terminal region of RTP801, the protein product of a hypoxia-inducible factor 1 (HIF-1)- responsive gene. Two members of this family expressed by Drosophila melanogaster, Scylla and Charybde, are designated by the GenBank as Hox targets. RTP801 is thought to be involved in various cellular processes. Its overexpression caused the apoptosis- resistant phenotype in cycling cells, and apoptosis sensitivity in growth arrested cells. Moreover, the protein product of the mouse homolog of RTP801 (dig2) is thought to be induced by diverse apoptotic signals, and also by dexamethasone treatment.


:

Pssm-ID: 462274  Cd Length: 116  Bit Score: 181.63  E-value: 3.50e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662626   139 LRAAKSRHLTCTEVSLPCDLTPSVAREIIRVSEKEPRGIRGCTIYIEFEDEpKNSRRIASIKVDSDTVSTFEVYLTLRQD 218
Cdd:pfam07809   1 LRAAKRTSLACSELLLPADLLHRIARDVLRLAESEPCGLRGALIDLCVEDG-DGCRRLGQIKVDPSTVPTFELTLVLRQD 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 24662626   219 HRGWTSLLPQF-MKSLAR--TITISPEYTITKNKLYS 252
Cdd:pfam07809  80 SSGWPSIQPLFkSFNLTRgsTLKLSPGFRLIKRKLYS 116
dermokine super family cl42387
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ...
 13-95 4.90e-03

dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts.


The actual alignment was detected with superfamily member cd21118:

Pssm-ID: 455732 [Multi-domain]  Cd Length: 495  Bit Score: 38.06  E-value: 4.90e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662626  13 YGSLQGSNKNKDWTSrlPPPSAytldlmSKKAKTTTGGSSNGSNATATSTTTSTSSSIKHKQPAGSSNNNVGQSQSKKTk 92
Cdd:cd21118 190 YGTVRGNNQNSGCTN--PPPSG------SHESFSNSGGSSSSGSSGSQGSHGSNGQGSSGSSGGQGNGGNNGSSSSNSG- 260


                ...
gi 24662626  93 PSG 95
Cdd:cd21118 261 NSG 263
 
Name Accession Description Interval E-value
RTP801_C pfam07809
RTP801 C-terminal region; The members of this family are sequences similar to the C-terminal ...
 139-252 3.50e-58

RTP801 C-terminal region; The members of this family are sequences similar to the C-terminal region of RTP801, the protein product of a hypoxia-inducible factor 1 (HIF-1)- responsive gene. Two members of this family expressed by Drosophila melanogaster, Scylla and Charybde, are designated by the GenBank as Hox targets. RTP801 is thought to be involved in various cellular processes. Its overexpression caused the apoptosis- resistant phenotype in cycling cells, and apoptosis sensitivity in growth arrested cells. Moreover, the protein product of the mouse homolog of RTP801 (dig2) is thought to be induced by diverse apoptotic signals, and also by dexamethasone treatment.


Pssm-ID: 462274  Cd Length: 116  Bit Score: 181.63  E-value: 3.50e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662626   139 LRAAKSRHLTCTEVSLPCDLTPSVAREIIRVSEKEPRGIRGCTIYIEFEDEpKNSRRIASIKVDSDTVSTFEVYLTLRQD 218
Cdd:pfam07809   1 LRAAKRTSLACSELLLPADLLHRIARDVLRLAESEPCGLRGALIDLCVEDG-DGCRRLGQIKVDPSTVPTFELTLVLRQD 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 24662626   219 HRGWTSLLPQF-MKSLAR--TITISPEYTITKNKLYS 252
Cdd:pfam07809  80 SSGWPSIQPLFkSFNLTRgsTLKLSPGFRLIKRKLYS 116
dermokine cd21118
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ...
 13-95 4.90e-03

dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts.


Pssm-ID: 411053 [Multi-domain]  Cd Length: 495  Bit Score: 38.06  E-value: 4.90e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662626  13 YGSLQGSNKNKDWTSrlPPPSAytldlmSKKAKTTTGGSSNGSNATATSTTTSTSSSIKHKQPAGSSNNNVGQSQSKKTk 92
Cdd:cd21118 190 YGTVRGNNQNSGCTN--PPPSG------SHESFSNSGGSSSSGSSGSQGSHGSNGQGSSGSSGGQGNGGNNGSSSSNSG- 260


                ...
gi 24662626  93 PSG 95
Cdd:cd21118 261 NSG 263
 
Name Accession Description Interval E-value
RTP801_C pfam07809
RTP801 C-terminal region; The members of this family are sequences similar to the C-terminal ...
 139-252 3.50e-58

RTP801 C-terminal region; The members of this family are sequences similar to the C-terminal region of RTP801, the protein product of a hypoxia-inducible factor 1 (HIF-1)- responsive gene. Two members of this family expressed by Drosophila melanogaster, Scylla and Charybde, are designated by the GenBank as Hox targets. RTP801 is thought to be involved in various cellular processes. Its overexpression caused the apoptosis- resistant phenotype in cycling cells, and apoptosis sensitivity in growth arrested cells. Moreover, the protein product of the mouse homolog of RTP801 (dig2) is thought to be induced by diverse apoptotic signals, and also by dexamethasone treatment.


Pssm-ID: 462274  Cd Length: 116  Bit Score: 181.63  E-value: 3.50e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662626   139 LRAAKSRHLTCTEVSLPCDLTPSVAREIIRVSEKEPRGIRGCTIYIEFEDEpKNSRRIASIKVDSDTVSTFEVYLTLRQD 218
Cdd:pfam07809   1 LRAAKRTSLACSELLLPADLLHRIARDVLRLAESEPCGLRGALIDLCVEDG-DGCRRLGQIKVDPSTVPTFELTLVLRQD 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 24662626   219 HRGWTSLLPQF-MKSLAR--TITISPEYTITKNKLYS 252
Cdd:pfam07809  80 SSGWPSIQPLFkSFNLTRgsTLKLSPGFRLIKRKLYS 116
dermokine cd21118
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ...
 13-95 4.90e-03

dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts.


Pssm-ID: 411053 [Multi-domain]  Cd Length: 495  Bit Score: 38.06  E-value: 4.90e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662626  13 YGSLQGSNKNKDWTSrlPPPSAytldlmSKKAKTTTGGSSNGSNATATSTTTSTSSSIKHKQPAGSSNNNVGQSQSKKTk 92
Cdd:cd21118 190 YGTVRGNNQNSGCTN--PPPSG------SHESFSNSGGSSSSGSSGSQGSHGSNGQGSSGSSGGQGNGGNNGSSSSNSG- 260


                ...
gi 24662626  93 PSG 95
Cdd:cd21118 261 NSG 263
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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