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Conserved domains on  [gi|24662077|ref|NP_648377|]
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uncharacterized protein Dmel_CG6674, isoform A [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSSC4 super family cl21120
Tumour suppressing sub-chromosomal transferable candidate 4; This family of proteins is ...
 9-149 7.21e-37

Tumour suppressing sub-chromosomal transferable candidate 4; This family of proteins is expressed from a gene cluster where in humans the TSSC4 gene is not imprinted. This same cluster is associated with the Beckwith-Wiedermann syndrome. This domain family is found in eukaryotes, and is typically between 120 and 147 amino acids in length. There is a conserved YSL sequence motif.


The actual alignment was detected with superfamily member pfam15264:

Pssm-ID: 434584  Cd Length: 126  Bit Score: 125.70  E-value: 7.21e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662077     9 DALFACLDDASKELRGTALDQSKAKAFSINALDRgnksgnesgqvmnyrqgrsivtgldaedgrlrrmrgkESIFKKPEL 88
Cdd:pfam15264   1 DSIFDCLEDAAKEAKPTVLDTSKSDPYDVDALER-------------------------------------ESIFKRPLL 43

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24662077    89 PIGRCLKPRK--------------TPDYQVNPHKWKKYSLSDV-DISEQSNSAAALSFL--RQMDAQREAEGVDNESP 149
Cdd:pfam15264  44 PPPRCLKRRKgrahrspagprvppVPDYVANPEKWTKYSLEDVaEMSEQSNTAAALSFLgsRELDAPRDYVPSFNQDP 121
 
Name Accession Description Interval E-value
TSSC4 pfam15264
Tumour suppressing sub-chromosomal transferable candidate 4; This family of proteins is ...
 9-149 7.21e-37

Tumour suppressing sub-chromosomal transferable candidate 4; This family of proteins is expressed from a gene cluster where in humans the TSSC4 gene is not imprinted. This same cluster is associated with the Beckwith-Wiedermann syndrome. This domain family is found in eukaryotes, and is typically between 120 and 147 amino acids in length. There is a conserved YSL sequence motif.


Pssm-ID: 434584  Cd Length: 126  Bit Score: 125.70  E-value: 7.21e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662077     9 DALFACLDDASKELRGTALDQSKAKAFSINALDRgnksgnesgqvmnyrqgrsivtgldaedgrlrrmrgkESIFKKPEL 88
Cdd:pfam15264   1 DSIFDCLEDAAKEAKPTVLDTSKSDPYDVDALER-------------------------------------ESIFKRPLL 43

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24662077    89 PIGRCLKPRK--------------TPDYQVNPHKWKKYSLSDV-DISEQSNSAAALSFL--RQMDAQREAEGVDNESP 149
Cdd:pfam15264  44 PPPRCLKRRKgrahrspagprvppVPDYVANPEKWTKYSLEDVaEMSEQSNTAAALSFLgsRELDAPRDYVPSFNQDP 121
 
Name Accession Description Interval E-value
TSSC4 pfam15264
Tumour suppressing sub-chromosomal transferable candidate 4; This family of proteins is ...
 9-149 7.21e-37

Tumour suppressing sub-chromosomal transferable candidate 4; This family of proteins is expressed from a gene cluster where in humans the TSSC4 gene is not imprinted. This same cluster is associated with the Beckwith-Wiedermann syndrome. This domain family is found in eukaryotes, and is typically between 120 and 147 amino acids in length. There is a conserved YSL sequence motif.


Pssm-ID: 434584  Cd Length: 126  Bit Score: 125.70  E-value: 7.21e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24662077     9 DALFACLDDASKELRGTALDQSKAKAFSINALDRgnksgnesgqvmnyrqgrsivtgldaedgrlrrmrgkESIFKKPEL 88
Cdd:pfam15264   1 DSIFDCLEDAAKEAKPTVLDTSKSDPYDVDALER-------------------------------------ESIFKRPLL 43

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24662077    89 PIGRCLKPRK--------------TPDYQVNPHKWKKYSLSDV-DISEQSNSAAALSFL--RQMDAQREAEGVDNESP 149
Cdd:pfam15264  44 PPPRCLKRRKgrahrspagprvppVPDYVANPEKWTKYSLEDVaEMSEQSNTAAALSFLgsRELDAPRDYVPSFNQDP 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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