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Conserved domains on  [gi|24661428|ref|NP_648293|]
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uncharacterized protein Dmel_CG4476 [Drosophila melanogaster]

Protein Classification

sodium-dependent transporter( domain architecture ID 10179381)

sodium-dependent transporter belonging to the sodium:neurotransmitter symporter (SNF) family is a amino acid:sodium cotransporter

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SLC6sbd cd10324
Solute carrier 6 family, neurotransmitter transporters; solute-binding domain; This family ...
52-526 0e+00

Solute carrier 6 family, neurotransmitter transporters; solute-binding domain; This family represents the solute-binding domain of SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family). These use sodium and chloride electrochemical gradients to catalyze the thermodynamically uphill movement of a variety of substrates, and include neurotransmitter transporters (NTTs). The latter are Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NTTs are widely expressed in the mammalian brain, and are involved in regulating neurotransmitter signaling and homeostasis, through facilitating the uptake of released neurotransmitters from the extracellular space into neurons and glial cells. NTTs are the target of a range of therapeutic drugs for the treatment of psychiatric diseases, such as major depression, anxiety disorders, attention deficit hyperactivity disorder and epilepsy. In addition, they are the primary targets of cocaine, amphetamines and other psychostimulants. This family also includes Drosophila Blot which is expressed primarily in epithelial tissues of ectodermal origin and in the nervous system of the embryo and larvae, but in addition found in the developing oocyte and the freshly laid egg. A lack or reduction of Blot function during oogenesis results in early arrest of embryonic development. 12 transmembrane helices (TMs) appears to be common for eukaryotic and some prokaryotic and archaeal SLC6s, (a core inverted topology repeat, TM1-5 and TM6-10, plus TMs11-12; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT), although a majority of bacterial, and some archaeal SLC6s lack TM12, for example the functional Fusobacterium nucleatum tyrosine transporter Tyt1.


:

Pssm-ID: 271359 [Multi-domain]  Cd Length: 415  Bit Score: 528.25  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  52 DNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVF-DFAPLMR 130
Cdd:cd10324   1 EQWGSKLEFLLSCIGYAVGLGNIWRFPYLAYENGGGAFLIPYLIMLFLVGIPLFYLELALGQYTSRGPVGAFwRIAPLFK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 131 GVGYAQLLALGVLATYYASVMALTLRYFFDSFaselpwsfcreewgdgcvsasggqplqgqlsrnfssstqlylqrivln 210
Cdd:cd10324  81 GVGYAQVLVSFLVAIYYNVIIAWTLYYLFASF------------------------------------------------ 112
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 211 etdsleegigyPSGSLALMLGISWLTVtlIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEK 290
Cdd:cd10324 113 -----------INWELFLCLLLAWILV--YLCKGVKSIGKGVKFTGPFPYVLLLFLLIRGVTLPGAGDGILFYLTPDWSK 179
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 291 LLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGTkDIASVV 370
Cdd:cd10324 180 LLDPKVWIAAATQIFFSLGIGFGGLITYASYNKFKNNIYRDALIVAILNTLTSLLAGFVIFSILGFLAHEPGT-PVEDVV 258
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 371 KAGPGLAFISYPDAIAKFKmFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNVKL--WIIVVSLSVIGFLVGLI 448
Cdd:cd10324 259 ASGPGLAFIVYPEAIAQMP-GPQLWSVLFFLMLFLLGLDSQFAMVEVIVTALADEFPKLRKrrWLVTLGVCVVGFLLGLP 337
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24661428 449 YITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSL 526
Cdd:cd10324 338 YTTPGGIYVLDLFDYYAAGFSLLVIALLELIAIAWIYGVDRFLEDIEFMLGIRPSIYWRICWKFITPVVLLIILVFSL 415
 
Name Accession Description Interval E-value
SLC6sbd cd10324
Solute carrier 6 family, neurotransmitter transporters; solute-binding domain; This family ...
52-526 0e+00

Solute carrier 6 family, neurotransmitter transporters; solute-binding domain; This family represents the solute-binding domain of SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family). These use sodium and chloride electrochemical gradients to catalyze the thermodynamically uphill movement of a variety of substrates, and include neurotransmitter transporters (NTTs). The latter are Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NTTs are widely expressed in the mammalian brain, and are involved in regulating neurotransmitter signaling and homeostasis, through facilitating the uptake of released neurotransmitters from the extracellular space into neurons and glial cells. NTTs are the target of a range of therapeutic drugs for the treatment of psychiatric diseases, such as major depression, anxiety disorders, attention deficit hyperactivity disorder and epilepsy. In addition, they are the primary targets of cocaine, amphetamines and other psychostimulants. This family also includes Drosophila Blot which is expressed primarily in epithelial tissues of ectodermal origin and in the nervous system of the embryo and larvae, but in addition found in the developing oocyte and the freshly laid egg. A lack or reduction of Blot function during oogenesis results in early arrest of embryonic development. 12 transmembrane helices (TMs) appears to be common for eukaryotic and some prokaryotic and archaeal SLC6s, (a core inverted topology repeat, TM1-5 and TM6-10, plus TMs11-12; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT), although a majority of bacterial, and some archaeal SLC6s lack TM12, for example the functional Fusobacterium nucleatum tyrosine transporter Tyt1.


Pssm-ID: 271359 [Multi-domain]  Cd Length: 415  Bit Score: 528.25  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  52 DNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVF-DFAPLMR 130
Cdd:cd10324   1 EQWGSKLEFLLSCIGYAVGLGNIWRFPYLAYENGGGAFLIPYLIMLFLVGIPLFYLELALGQYTSRGPVGAFwRIAPLFK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 131 GVGYAQLLALGVLATYYASVMALTLRYFFDSFaselpwsfcreewgdgcvsasggqplqgqlsrnfssstqlylqrivln 210
Cdd:cd10324  81 GVGYAQVLVSFLVAIYYNVIIAWTLYYLFASF------------------------------------------------ 112
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 211 etdsleegigyPSGSLALMLGISWLTVtlIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEK 290
Cdd:cd10324 113 -----------INWELFLCLLLAWILV--YLCKGVKSIGKGVKFTGPFPYVLLLFLLIRGVTLPGAGDGILFYLTPDWSK 179
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 291 LLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGTkDIASVV 370
Cdd:cd10324 180 LLDPKVWIAAATQIFFSLGIGFGGLITYASYNKFKNNIYRDALIVAILNTLTSLLAGFVIFSILGFLAHEPGT-PVEDVV 258
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 371 KAGPGLAFISYPDAIAKFKmFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNVKL--WIIVVSLSVIGFLVGLI 448
Cdd:cd10324 259 ASGPGLAFIVYPEAIAQMP-GPQLWSVLFFLMLFLLGLDSQFAMVEVIVTALADEFPKLRKrrWLVTLGVCVVGFLLGLP 337
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24661428 449 YITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSL 526
Cdd:cd10324 338 YTTPGGIYVLDLFDYYAAGFSLLVIALLELIAIAWIYGVDRFLEDIEFMLGIRPSIYWRICWKFITPVVLLIILVFSL 415
SNF pfam00209
Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.
51-551 1.41e-166

Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.


Pssm-ID: 395155 [Multi-domain]  Cd Length: 517  Bit Score: 485.64  E-value: 1.41e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428    51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFD-FAPLM 129
Cdd:pfam00209   1 RETWSGKLDFLLSVIGFAVGLGNVWRFPYLCYKNGGGAFLIPYLIMLIFAGIPLFFLELALGQYTREGAIGVWRkICPLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428   130 RGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWGDG-CVSASGgqPLQGQLSRNFSSSTQLYLQRIV 208
Cdd:pfam00209  81 KGIGYASMVIAFYIGIYYNVIIAWALYYLFSSFTTELPWASCNNSWNTPnCTEFFS--ANNTTNSLNKTSPVEEFWERKV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428   209 LNETDSLEEgIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQW 288
Cdd:pfam00209 159 LKLSDGIED-LGGLRWPLALCLLVAWVVVYFCIWKGVKSSGKVVYFTATFPYVVLLVLLVRGVTLPGAADGILFYLTPDW 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428   289 EKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGtKDIAS 368
Cdd:pfam00209 238 SKLLEPQVWIDAATQIFFSLGIGFGGLIAFASYNKFHNNCYRDALIVSFINSATSFLAGFVIFSVLGFMAQEQG-VPISE 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428   369 VVKAGPGLAFISYPDAIAKFKmFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNVKLW---IIVVSLSVIGFLV 445
Cdd:pfam00209 317 VAESGPGLAFIAYPEAVTMLP-LSPFWSVLFFLMLITLGLDSQFGGVEGIITALVDEFPILLRKrreLFTLIVCVASFLL 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428   446 GLIYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYS 525
Cdd:pfam00209 396 GLILVTEGGIYVFTLFDYYAASFSLLFVAFFECIAIAWVYGIDRFYDDIKEMLGFRPGLFWRLCWKFVSPLILLFLFIFS 475
                         490       500
                  ....*....|....*....|....*.
gi 24661428   526 LLTMRPLSYNGQEFPLVYRVVGWCVS 551
Cdd:pfam00209 476 IVQYQPLTYNNYVYPNWANALGWLMA 501
YocR COG0733
Na+-dependent transporter, SNF family [General function prediction only];
49-526 1.69e-86

Na+-dependent transporter, SNF family [General function prediction only];


Pssm-ID: 440497 [Multi-domain]  Cd Length: 444  Bit Score: 276.98  E-value: 1.69e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  49 KARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFA-- 126
Cdd:COG0733   3 SKREQWSSRLGFILAAAGSAVGLGNIWRFPYVAGENGGGAFLLPYLLALLLIGIPLLIAEFAIGRRGRKSPVGAFRKLap 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 127 -PLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASElpwsfcreeWGDGCVSASGGQplqgqlsrnfssstqlylq 205
Cdd:COG0733  83 gKKWEWIGWLGVLGAFLILSYYSVVAGWVLAYLFKSLTGA---------FGGLDAEDAGAF------------------- 134
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 206 rivlnetdsLEEGIGYPSGSLALMLgISWLTVTLIIIRGVKSS-GKAAYVL--ALFpyVVMFILLVRALTLPGAYDGVMY 282
Cdd:COG0733 135 ---------FGAFLSSPGEVLIWHL-LFLLLTALIVARGVQKGiEKASKILmpLLF--VLLIILVIRALTLPGAAEGLKF 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 283 FLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESG 362
Cdd:COG0733 203 LFTPDFSKLTDPEVWLAALGQAFFSLSLGMGIMITYGSYLPKDEDLPRSALIVALLDTLVALLAGLAIFPAVFAFGLEPA 282
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 363 tkdiasvvkAGPGLAFISYPDAIAkfKM-FPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFvNVKLWIIVVSLSVI 441
Cdd:COG0733 283 ---------AGPGLAFVTLPAVFA--QMpGGRLFGVLFFLLLLFAALTSAISLLEVVVAALIDKF-GLSRKKATLIVGLL 350
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 442 GFLVGLIYIT------PGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTP 515
Cdd:COG0733 351 IFLLGIPSALsfnvsvTIGLTFFDLVDFLVSNILLPLGGLLIAIFVGWVLGKEKLREELNAGSDIKLGKWWRFLIRYVAP 430
                       490
                ....*....|.
gi 24661428 516 LVMLVILVYSL 526
Cdd:COG0733 431 VALLIIFLNGL 441
 
Name Accession Description Interval E-value
SLC6sbd cd10324
Solute carrier 6 family, neurotransmitter transporters; solute-binding domain; This family ...
52-526 0e+00

Solute carrier 6 family, neurotransmitter transporters; solute-binding domain; This family represents the solute-binding domain of SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family). These use sodium and chloride electrochemical gradients to catalyze the thermodynamically uphill movement of a variety of substrates, and include neurotransmitter transporters (NTTs). The latter are Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NTTs are widely expressed in the mammalian brain, and are involved in regulating neurotransmitter signaling and homeostasis, through facilitating the uptake of released neurotransmitters from the extracellular space into neurons and glial cells. NTTs are the target of a range of therapeutic drugs for the treatment of psychiatric diseases, such as major depression, anxiety disorders, attention deficit hyperactivity disorder and epilepsy. In addition, they are the primary targets of cocaine, amphetamines and other psychostimulants. This family also includes Drosophila Blot which is expressed primarily in epithelial tissues of ectodermal origin and in the nervous system of the embryo and larvae, but in addition found in the developing oocyte and the freshly laid egg. A lack or reduction of Blot function during oogenesis results in early arrest of embryonic development. 12 transmembrane helices (TMs) appears to be common for eukaryotic and some prokaryotic and archaeal SLC6s, (a core inverted topology repeat, TM1-5 and TM6-10, plus TMs11-12; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT), although a majority of bacterial, and some archaeal SLC6s lack TM12, for example the functional Fusobacterium nucleatum tyrosine transporter Tyt1.


Pssm-ID: 271359 [Multi-domain]  Cd Length: 415  Bit Score: 528.25  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  52 DNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVF-DFAPLMR 130
Cdd:cd10324   1 EQWGSKLEFLLSCIGYAVGLGNIWRFPYLAYENGGGAFLIPYLIMLFLVGIPLFYLELALGQYTSRGPVGAFwRIAPLFK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 131 GVGYAQLLALGVLATYYASVMALTLRYFFDSFaselpwsfcreewgdgcvsasggqplqgqlsrnfssstqlylqrivln 210
Cdd:cd10324  81 GVGYAQVLVSFLVAIYYNVIIAWTLYYLFASF------------------------------------------------ 112
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 211 etdsleegigyPSGSLALMLGISWLTVtlIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEK 290
Cdd:cd10324 113 -----------INWELFLCLLLAWILV--YLCKGVKSIGKGVKFTGPFPYVLLLFLLIRGVTLPGAGDGILFYLTPDWSK 179
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 291 LLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGTkDIASVV 370
Cdd:cd10324 180 LLDPKVWIAAATQIFFSLGIGFGGLITYASYNKFKNNIYRDALIVAILNTLTSLLAGFVIFSILGFLAHEPGT-PVEDVV 258
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 371 KAGPGLAFISYPDAIAKFKmFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNVKL--WIIVVSLSVIGFLVGLI 448
Cdd:cd10324 259 ASGPGLAFIVYPEAIAQMP-GPQLWSVLFFLMLFLLGLDSQFAMVEVIVTALADEFPKLRKrrWLVTLGVCVVGFLLGLP 337
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24661428 449 YITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSL 526
Cdd:cd10324 338 YTTPGGIYVLDLFDYYAAGFSLLVIALLELIAIAWIYGVDRFLEDIEFMLGIRPSIYWRICWKFITPVVLLIILVFSL 415
SLC6sbd-TauT-like cd11496
Na(+)- and Cl(-)-dependent taurine transporter TauT, and related proteins; solute-binding ...
51-584 1.48e-167

Na(+)- and Cl(-)-dependent taurine transporter TauT, and related proteins; solute-binding domain; This subgroup represents the solute-binding domain of TauT-like Na(+)- and Cl(-)-dependent transporters. Family members include: human TauT which transports taurine, human GAT1, GAT2, and GAT3, and BGT1, which transport gamma-aminobutyric acid (GABA), and human CT1 which transports creatine. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271387  Cd Length: 543  Bit Score: 489.01  E-value: 1.48e-167
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFAPLMR 130
Cdd:cd11496   1 RGKWSNKIDFLLSVAGYAIGLGNVWRFPYLCYKNGGGAFLIPYFIFLVLCGIPIFFLETSLGQYTSQGGITAWKICPLFK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 131 GVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWG-DGCVSASGGQPL-----QGQLSRNFSSSTQLYL 204
Cdd:cd11496  81 GIGYASAVIVFWLNIYYIVILAWALFYLFNSFTSPLPWTTCDNWWNtECCVEFYSNNNLsnsreNASNNTNATSPVEEFW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 205 QRIVLNETDSLEEgIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFL 284
Cdd:cd11496 161 ERRVLGISDGIDE-IGSIRWELVLCLLLAWVIVYFCIWKGVKSTGKVVYFTATFPYVMLIILLIRGVTLPGASDGIKFYL 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 285 TPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGTk 364
Cdd:cd11496 240 KPDLTKLLDPQVWIDAGTQIFFSYGIGLGSLTALGSYNKFNNNCYKDSIILCFLNSGTSFFAGFAIFSILGFMAQEQGV- 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 365 DIASVVKAGPGLAFISYPDAIAKFKmFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNVKLW-----IIVVSLS 439
Cdd:cd11496 319 PISEVAESGPGLAFIAYPRAVSLLP-LPQLWAVLFFIMLLLLGLDSQFVGVEGFVTAIVDLYPRVLRRryrreIFVAIVC 397
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 440 VIGFLVGLIYITPGGQHIITLMDFHGVTFVS-LVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVM 518
Cdd:cd11496 398 LVSFLIGLPMVTEGGIYVFQLFDYYAASGIClLWLAFFECIAISWVYGADRFYDNIKDMIGYRPGPWWKYCWLFGTPAIC 477
                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24661428 519 LVILVYSLLTMRPLSYN-GQEFPLVYRVVGWCVSG----CIIGqlfyWAGYANFKQPkGSLKSRINNSIKP 584
Cdd:cd11496 478 LGIFIFSLVKYTPLTYGnTYVYPWWAEAIGWFLALssmlCIPL----YAIYELLRTP-GTFKERLRKLTTP 543
SNF pfam00209
Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.
51-551 1.41e-166

Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.


Pssm-ID: 395155 [Multi-domain]  Cd Length: 517  Bit Score: 485.64  E-value: 1.41e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428    51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFD-FAPLM 129
Cdd:pfam00209   1 RETWSGKLDFLLSVIGFAVGLGNVWRFPYLCYKNGGGAFLIPYLIMLIFAGIPLFFLELALGQYTREGAIGVWRkICPLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428   130 RGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWGDG-CVSASGgqPLQGQLSRNFSSSTQLYLQRIV 208
Cdd:pfam00209  81 KGIGYASMVIAFYIGIYYNVIIAWALYYLFSSFTTELPWASCNNSWNTPnCTEFFS--ANNTTNSLNKTSPVEEFWERKV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428   209 LNETDSLEEgIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQW 288
Cdd:pfam00209 159 LKLSDGIED-LGGLRWPLALCLLVAWVVVYFCIWKGVKSSGKVVYFTATFPYVVLLVLLVRGVTLPGAADGILFYLTPDW 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428   289 EKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGtKDIAS 368
Cdd:pfam00209 238 SKLLEPQVWIDAATQIFFSLGIGFGGLIAFASYNKFHNNCYRDALIVSFINSATSFLAGFVIFSVLGFMAQEQG-VPISE 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428   369 VVKAGPGLAFISYPDAIAKFKmFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNVKLW---IIVVSLSVIGFLV 445
Cdd:pfam00209 317 VAESGPGLAFIAYPEAVTMLP-LSPFWSVLFFLMLITLGLDSQFGGVEGIITALVDEFPILLRKrreLFTLIVCVASFLL 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428   446 GLIYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYS 525
Cdd:pfam00209 396 GLILVTEGGIYVFTLFDYYAASFSLLFVAFFECIAIAWVYGIDRFYDDIKEMLGFRPGLFWRLCWKFVSPLILLFLFIFS 475
                         490       500
                  ....*....|....*....|....*.
gi 24661428   526 LLTMRPLSYNGQEFPLVYRVVGWCVS 551
Cdd:pfam00209 476 IVQYQPLTYNNYVYPNWANALGWLMA 501
SLC6sbd_PROT cd11500
Na(+)- and Cl(-)-dependent L-proline transporter PROT; solute-binding domain; PROT is a ...
51-590 3.30e-152

Na(+)- and Cl(-)-dependent L-proline transporter PROT; solute-binding domain; PROT is a high-affinity L-proline transporter that transports L-proline, and may have a role in excitatory neurotransmission. Human PROT is encoded by the SLC6A7 gene, a potential susceptible gene for asthma. PROT is expressed in the brain. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271390  Cd Length: 541  Bit Score: 449.97  E-value: 3.30e-152
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFAPLMR 130
Cdd:cd11500   1 RGQWGGKLEFLLSCIGYCVGLGNVWRFPYLCYRNGGGAFLIPYFIMLAFCGIPLFFMELSLGQYGSLGPLTVWKCCPIFK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 131 GVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWG-DGCVSASGGQPLQGQLSRNFSSStQLYLQRIVL 209
Cdd:cd11500  81 GIGYGMLLVSGLVCIYYNVIIAWTLFYLFASFTSVLPWEHCGNWWNtESCLEHRGNGALTVNLTRTVSPS-EEYWNRRVL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 210 NETDSleEGIGYP---SGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTP 286
Cdd:cd11500 160 GIQGS--SGIGDPgevRWELALCLLLAWVIVFFCLFKGVKSSGKVVYFTATFPYIILIVLLVRGVTLEGALKGIQFYLTP 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 287 QWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGTkDI 366
Cdd:cd11500 238 DFHRLASSQVWYDAASQIFYSLGIGFGGLLTMASYNKFNNNIYRDTLIITLGNCITSVFAGFAIFSVLGHMAHELGV-PV 316
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 367 ASVVKAGPGLAFISYPDAIAKFKMfPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNV----KLWIIVVsLSVIG 442
Cdd:cd11500 317 KDVADAGPGLAFVAYPEALTLLPV-SPFWSILFFFMLLTLGLDSQFAMLETIVTAVTDEFPYLlrkyKTWFLGL-ICVGM 394
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 443 FLVGLIYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVIL 522
Cdd:cd11500 395 YLLGLLLVTDGGMYWLTLMDWYSASFGLMVLALFMCLAISWVYGIQRFCRDIKMMIGFEPNLYFKACWMFISPALLLFIL 474
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24661428 523 VYSLLTMRPLSYNGQEFPLVYRVVGWCVSGCIIGQLFYWAGYANFKQpKGSLKSRINNSIKPHSDWGP 590
Cdd:cd11500 475 VYSIVKYQPSEYGSYRYPPWAELLGILMGLLSCLMIPIGAIVAILRE-EGSLWERLKQACRPAMDWGP 541
SLC6sbd_SERT-like cd11497
Na(+)- and Cl(-)-dependent monoamine transporters, SERT, NET, DAT1 and related proteins; ...
51-584 7.85e-148

Na(+)- and Cl(-)-dependent monoamine transporters, SERT, NET, DAT1 and related proteins; solute binding domain; This subgroup represents the solute-binding domain of transmembrane transporters that transport monoamine neurotransmitters from synaptic spaces into presynaptic neurons. Members include: NET which transports norepinephrine, SERT which transports serotonin, and DAT1 which transports dopamine. These transporters may play a role in diseases including depression, anxiety disorders, attention-deficit hyperactivity disorder, and in the control of human behavior and emotional states. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271388  Cd Length: 537  Bit Score: 438.67  E-value: 7.85e-148
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFD-FAPLM 129
Cdd:cd11497   1 RETWGKKIDFLLSVIGFAVDLGNVWRFPYLCYKNGGGAFLIPYLIMLIFGGLPLFYMELALGQFNRSGCITVWKkICPLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 130 RGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWG-DGCVSASggqPLQGQLSRNFS---SSTQLYLQ 205
Cdd:cd11497  81 KGVGYAICIIAFYVAFYYNVIIAWALYYLFSSFTSELPWTSCNNPWNtPNCTDVS---NRNNSSSINGTgltSPAEEYFE 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 206 RIVLNETDSleEGI---GYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMY 282
Cdd:cd11497 158 RKVLELQKS--EGIddlGPIKWQLALCLFAVFIIVYFSLWKGVKSSGKVVWVTATMPYVVLSILLIRGLTLPGASDGIKY 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 283 FLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESG 362
Cdd:cd11497 236 YLTPDFSKLKDPEVWIDAATQIFFSLGPGFGVLLALSSYNKFHNNCYRDALVTSSINCATSFFSGFVIFSVLGYMAHKQN 315
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 363 tKDIASVVKAGPGLAFISYPDAIAkfKMFPQVF-SLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNVKLW--IIVVSLS 439
Cdd:cd11497 316 -VPIEDVATEGPGLVFIVYPEAIA--TLPGSTFwAIIFFLMLITLGLDSTFGGLEAVITGLCDEFPFLSRRreLFVLGLV 392
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 440 VIGFLVGLIYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVML 519
Cdd:cd11497 393 IICFLLALPTVTYGGIYVVTLLDRYAAGISILFIVFFEAVAVSWFYGVDRFSDDIEEMLGFRPGLYWRVCWKFISPIFLL 472
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24661428 520 VILVYSLLTMRPLSYNGQEFPLVYRVVGWCVSGCIIGQLFYWAGYANFKQPkGSLKSRINNSIKP 584
Cdd:cd11497 473 FIVIFSLVSYEPLQYQDYVYPPWANVVGWVIACSSIVLIPIYAIYKLISTP-GTFRQRIAYCITP 536
SLC6sbd-B0AT-like cd10332
System B(0) neutral amino acid transporter AT1, 2 and 3, and related proteins; solute-binding ...
51-534 3.38e-137

System B(0) neutral amino acid transporter AT1, 2 and 3, and related proteins; solute-binding domain; This subgroup includes the solute-binding domain of transmembrane transporters, which transport, i) neutral amino acids: NTT4 (also called XT1), SBAT1 (also called B0AT2, v7-3, NTT7-3), and B0AT1 (also called HND); the human genes encoding these are SLC6A17, SLC6A15, and SLC6A19 respectively, ii) glycine: B0AT3 (also called Xtrp2, XT2), iii) imino acids, such as proline, pipecolate, MeAIB, and sarcosine: SIT1 (also called XTRP3, XT3, IMINO). The human genes encoding B0AT3 and SIT1 are SLC6A18 and SLC6A20 respectively. Transporters in this subgroup may play a role in disorders including major depression, Hartnup disorder, increased susceptibility to myocardial infarction, and iminoglycinuria. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271364  Cd Length: 531  Bit Score: 410.89  E-value: 3.38e-137
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFD-FAPLM 129
Cdd:cd10332   1 RPAWDNKLQFLLATIGYAVGLGNVWRFPYLCQKNGGGAFLIPYFIMLILEGIPLFFLELAIGQRLRKGSIGVWNtISPYL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 130 RGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFC-REEWGDGCVSASGgqplqgqlsrnFSSSTQLYLQRIV 208
Cdd:cd10332  81 GGVGIASVVVSFLVALYYNVIIAWCFFYLFNSFQYPLPWSSCpTNGNGTGYVEECA-----------KSSPTQYFWYRTT 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 209 LNETDSLEEGIGYpSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQW 288
Cdd:cd10332 150 LDISPSIDESGGL-NWWMTLCLLLAWIIVYLCMMKGIKSSGKVVYFTATFPYIVLIIFFIRGLTLKGAGDGLKHMFTPKF 228
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 289 EKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILG----------NLA 358
Cdd:cd10332 229 EKLLDPQVWLDAATQIFFSLGLGFGSLIAFSSYNPPKNNCQRDAVLVSLINCFTSIFASIVVFSVLGfkinnvtlteNQT 308
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 359 HESGTKDIA---SVVKAGPGLAFISYPDAIAKFKMfPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKD--QFVNVKLWI 433
Cdd:cd10332 309 LGLTNCSLEdelDEAVQGTGLAFIVFTEAITKMPG-APFWSVLFFLMLLTLGLGSMFGTLEGVVTPLFDskILPKVPKEY 387
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 434 IVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIV 513
Cdd:cd10332 388 LTGLVCLVCFLIGLIFTQRSGNYWVQMFDSYAGTLPLLIIALFEMIAVSYVYGLDRFEEDIEYMTGKRPGWYWKITWRYV 467
                       490       500
                ....*....|....*....|...
gi 24661428 514 TPLVMLVILVYSLLTM--RPLSY 534
Cdd:cd10332 468 SPLLMLVILVASIIQLitKPPTY 490
SLC6sbd_GlyT2 cd11499
Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain; GlyT2 (also ...
51-590 2.09e-135

Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain; GlyT2 (also called NET1) is a membrane-bound transporter that re-uptakes glycine from the synaptic cleft. Human GlyT2 is encoded by the SLC6A5 gene. GlyT2 is expressed in brain and spinal cord. GlyT2 may play a role in pain, and in spasticity. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271389  Cd Length: 597  Bit Score: 408.62  E-value: 2.09e-135
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFAPLMR 130
Cdd:cd11499   1 RGNWSNKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLIMLALAGLPIFLLEVSLGQFASQGPVSVWKAIPALQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 131 GVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWG------------DGCVSASggQP----------- 187
Cdd:cd11499  81 GCGIAMLIISVLIAIYYNIIMCYTLFYLFASLVEVLPWASCNNPWNtpeckdkdmlllDSCIISD--RPiiqiknstfcm 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 188 ----------LQGQLSRNFSSSTQLYLQRIVLNetdsLEEGIGYPSG---SLALMLGISWLTVTLIIIRGVKSSGKAAYV 254
Cdd:cd11499 159 taypnvtmvnFTSVDNKTFVSGSEEYFKYNVLK----ISAGIEYPGEirwPLAACLFLAWLIVYASLAKGIKTSGKVVYF 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 255 LALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANI 334
Cdd:cd11499 235 TATFPYVVLVILLIRGVTLPGAGSGIWYFITPKWEKLNDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLI 314
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 335 VTTLDTFTSLLSGVIIFGILGNLAHESGTkDIASVVKAGPGLAFISYPDAIAKFKMFPqVFSLLFFAMLFMLGVGSNVGM 414
Cdd:cd11499 315 VTCTNSATSIFAGFVIFSVIGFMAHELKV-PIESVADQGPGIAFVVYPEALTRLPLSP-FWAIIFFLMLLTLGLDTMFAT 392
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 415 VSCIMTVLKDQF-----VNVKLWIIVVSLSVigFLVGLIYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKR 489
Cdd:cd11499 393 IETIVTSVSDEFpkylrTHKPQFTLVCCLSF--FIMGFPMITQGGIYMLQLVDTYAASYSLVIIAIFELVGISYIYGLQR 470
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 490 LCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLSYNGQEFPLVYRVVGWCVSGCIIGQLFYWAGYANFKQ 569
Cdd:cd11499 471 FCEDIEMMIGFQPNKFWKVCWAFVTPTILTFILAFSFYQWEPMTYGSYTYPNWSMVLGWLMLACSVIWIPIMFVIKMHLA 550
                       570       580
                ....*....|....*....|.
gi 24661428 570 PkGSLKSRINNSIKPHSDWGP 590
Cdd:cd11499 551 P-GSFIERLKLVCSPQPDWGP 570
SLC6sbd_SERT-like_u1 cd11556
uncharacterized subgroup of the SERT-like Na(+)- and Cl(-)-dependent monoamine transporter ...
51-584 1.70e-130

uncharacterized subgroup of the SERT-like Na(+)- and Cl(-)-dependent monoamine transporter subfamily; solute binding domain; SERT-like Na(+)- and Cl(-)-dependent monoamine transporters, transport monoamine neurotransmitters from synaptic spaces into presynaptic neurons. Members include: the norepinephrine transporter NET, the serotonin transporter SERT , and the dopamine transporter DAT1. These latter may play a role in diseases or disorders including depression, anxiety disorders, and attention-deficit hyperactivity disorder, and in the control of human behavior and emotional states. They belongs to the solute carrier 6 (SLC6) transporter family. Members of this subgroup are uncharacterized.


Pssm-ID: 271405  Cd Length: 552  Bit Score: 394.53  E-value: 1.70e-130
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFD-FAPLM 129
Cdd:cd11556   1 RETWSKKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLIPYGIMLVVGGIPLFYMELALGQYNRKGAITSWGrLCPLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 130 RGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWGD--------------GCVSASGGQPL--QGQLS 193
Cdd:cd11556  81 KGIGYAVVLIAFYVDFFYNVIIAWSLYYFFASFTFNLPWTSCNNSWNTpncrefhwsedgtvPCRSANQSFSAenQSAQS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 194 RNFSSSTQLYLQRIVLNETDSleEGIGYPsGSLALMLGISWLTVTLIII----RGVKSSGKAAYVLALFPYVVMFILLVR 269
Cdd:cd11556 161 ENFTSAASEYFERGVLELNRS--EGVHDL-GNIRWDIALCLFAVYLICYfslwKGIHTSGKVVWFTALFPYVVLFILLIR 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 270 ALTLPGAYDGVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVI 349
Cdd:cd11556 238 GVTLPGSFNGIQYYLTPNFEALKKAEVWVDAATQVFFSLGPGFGVLLAYASYNKFHNNVYKDALLTSFINCATSFLSGFV 317
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 350 IFGILGNLAHESGtKDIASVVKAGPGLAFISYPDAIAKFKMFPqVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNV 429
Cdd:cd11556 318 IFSVLGYMAHRSG-VPIEDVATEGPGLVFVVYPEALSTMPGST-FWSLIFFMMLMTLGLDSSFGGSEAIITALSDEFPII 395
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 430 K--LWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYR 507
Cdd:cd11556 396 KrhRELFVGCLFSFYFVIGLASCTQGGFYFFHLLDRYAAGYSILIAVLFEAIAVSWIYGTDRFCQDIKEMLGFPPGIYWK 475
                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24661428 508 ICWSIVTPLVMLVILVYSLLTMRPLSYNGQEFPLVYRVVGWCVSGCIIGQLFYWAGYANFKQPkGSLKSRINNSIKP 584
Cdd:cd11556 476 VCWKFIAPIFLLFIITYGLIGYQPLTYDDYVYPTWANALGWCIAGSSISMIPIVAIYKLLSTP-GTLRQRFKILTTP 551
SLC6sbd_GAT1 cd11506
Na(+)- and Cl(-)-dependent GABA transporter 1; solute-binding domain; GAT1 transports ...
31-595 3.30e-130

Na(+)- and Cl(-)-dependent GABA transporter 1; solute-binding domain; GAT1 transports gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. Human GAT1 is encoded by the SLC6A1 gene. GAT1 is expressed in brain and peripheral nervous system. The antiepileptic drug, Tiagabine, inhibits GAT1. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212075 [Multi-domain]  Cd Length: 598  Bit Score: 395.50  E-value: 3.30e-130
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  31 KPSLLPMALES-SELSPDRkarDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEM 109
Cdd:cd11506  25 KPKTLVVKVQKkKTDLPDR---DTWKGKFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLEC 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 110 LLGQFSSRGIVQVFDFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWG-DGCVSASGGQPl 188
Cdd:cd11506 102 SLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIIAWAIYYLYNSFTTTLPWKSCDNPWNtDRCFSNYSMAN- 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 189 qgqlSRNFSSSTQLYLQRIVLNETDSLEE--GIGYPsgsLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFIL 266
Cdd:cd11506 181 ----TTNMTSAVVEFWERNMHQMTDGLEKpgQIRWP---LAITLAIAWVLVYFCIWKGVGWTGKVVYFSATYPYIMLFIL 253
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 267 LVRALTLPGAYDGVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLS 346
Cdd:cd11506 254 FFRGVTLPGAKEGILFYITPNFSKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNPFHNNVYRDSIIVCCINSCTSMFA 333
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 347 GVIIFGILGNLAHESgTKDIASVVKAGPGLAFISYPDAIAKFKMFPqVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQF 426
Cdd:cd11506 334 GFVIFSIVGFMAHVT-KRPIADVAASGPGLAFLAYPEAVTQLPISP-LWAVLFFSMLLMLGIDSQFCTVEGFITALVDEF 411
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 427 ---VNVKLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLVSAI-FELIAVGWIYGTKRLCQDAEYMLNIKT 502
Cdd:cd11506 412 prlLRNRREIFIAVVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVfFECVSISWFYGVNRFYDNIEEMVGYRP 491
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 503 SNYYRICWSIVTPLVMLVILVYSLLTMRPLSYNGQEFPLVYRVVGWCVSgciIGQLFYWAGYAN--FKQPKGSLKSRINN 580
Cdd:cd11506 492 CIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGNYVFPKWGQGVGWFMA---LSSMVLIPGYMAymFLTLKGSLKQRLQV 568
                       570       580
                ....*....|....*....|
gi 24661428 581 SIKP-----HSDWGPSDPKK 595
Cdd:cd11506 569 MIQPtedivTPENGPEQQQQ 588
SLC6sbd_GlyT1 cd11498
Na(+)- and Cl(-)-dependent glycine transporter GlyT1; solute-binding domain; GlyT1 is a ...
51-591 3.66e-128

Na(+)- and Cl(-)-dependent glycine transporter GlyT1; solute-binding domain; GlyT1 is a membrane-bound transporter that re-uptakes glycine from the synaptic cleft. Human GlyT1 is encoded by the SLC6A9 gene. GlyT1 is expressed in brain, pancreas, uterus, stomach, spleen, liver, and retina. GlyT1 may play a role in schizophrenia. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212067  Cd Length: 585  Bit Score: 389.66  E-value: 3.66e-128
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFAPLMR 130
Cdd:cd11498  17 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLVFCGIPLFFMELSFGQFASQGCLGVWRVSPMFK 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 131 GVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWG--------DGCVSASGGQPLQGQLS--------- 193
Cdd:cd11498  97 GVGYGMMVVSTYIGIYYNVVICIAFYYFFMSMTRVLPWTYCNNPWNtpdcagvlSTNRSNATFANMSAVVSnltellnrt 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 194 RNFSSSTQLYLQRIVLNetdsLEEGIG-YPSGSLALM--LGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRA 270
Cdd:cd11498 177 LKRTSPSEEYWRRYVLN----ISDDIGnFGEVRLPLLgcLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFIRG 252
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 271 LTLPGAYDGVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVII 350
Cdd:cd11498 253 ITLEGAISGIMYYLTPQWDKILDAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSIIISITNCATSVYAGFVI 332
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 351 FGILGNLAHESGTkDIASVVKAGPGLAFISYPDAIAKFKMFPqVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNVk 430
Cdd:cd11498 333 FSILGFMANHLGV-DVSEVADHGPGLAFVAYPEALTLLPISP-LWSLLFFFMLILLGLGTQFCLLETLVTAVVDEIGND- 409
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 431 lWII------VVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSN 504
Cdd:cd11498 410 -WIIrnktyvTLGVAIIGFLLGIPLTTQAGIYWLLLMDNYAASFSLVIISCIMCIAIMYIYGHRNYFKDIEMMLGFPPPL 488
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 505 YYRICWSIVTPLVMLVILVYSLLTMRPLSYNGQEFPLVYRVVGWCVSGCIIGQLFYWAGYANFKQPKGSLKSRINNSIKP 584
Cdd:cd11498 489 FFQICWRFVSPAIIFFILIFTVIQYRPITYNDYVYPGWAIVIGFLMALSSVICIPIYAIFKICMSEGDTFLERLKNAVKP 568

                ....*..
gi 24661428 585 HSDWGPS 591
Cdd:cd11498 569 SKDWGPA 575
SLC6sbd_BGT1 cd11511
Na(+)- and Cl(-)-dependent betaine/GABA transporter-1, and related proteins; solute-binding ...
51-584 3.16e-125

Na(+)- and Cl(-)-dependent betaine/GABA transporter-1, and related proteins; solute-binding domain; BGT1 is a relatively low-affinity transporter of gamma-aminobutyric acid (GABA), and can also transport betaine. GABA is the main inhibitory neurotransmitter within the mammalian CNS. Human BGT1 is encoded by the SLC6A12 gene, and is similar to mouse GAT2. Mouse GAT2 plays a role in transporting GABA across the blood-brain barrier. In addition to being expressed in cells of the central nervous system, BGT1 is expressed in peripheral tissues, including kidney, liver, and heart. An association has been shown between the SLC6A12 gene and the occurrence of aspirin-intolerant asthma, and BGT1 is a drug target for antiepileptic drugs. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212080  Cd Length: 541  Bit Score: 380.81  E-value: 3.16e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVF-DFAPLM 129
Cdd:cd11511   2 RGQWRNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYLIFLFTCGIPLFFLETALGQYTSQGGVTAWrKICPIF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 130 RGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWG-DGCVSASGGQPLQGQ-LSRNFSSSTQLYLQRI 207
Cdd:cd11511  82 EGIGYASQVIESYLNVYYIIILSWALFYLFSSFTSVLPWATCNNPWNsDLCVDFLNHSGADNRtPPENATSPVMEFWEKR 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 208 VLNETDSLEEgIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQ 287
Cdd:cd11511 162 VLGLTDGIHK-LGTVRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVILLVRGVTLPGAAEGIIFYLKPD 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 288 WEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGTKdIA 367
Cdd:cd11511 241 LSRLADPQVWMDAGTQILFSYAICQGCLTALGSYNKYTNNCYRDCIMLCFLNSATSFVAGFAIFSVLGFMAREQGVP-IS 319
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 368 SVVKAGPGLAFISYPDAIAkfkMFP--QVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNV-----KLWIIVVSLSV 440
Cdd:cd11511 320 EVAESGPGLAFIAYPTAVT---MMPvsQLWSCLFFLMLIFLGLDSQFVCVESMVTASIDMFPGVfrkkgRRELLILAIAV 396
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 441 IGFLVGLIYITPGGQHIITLMDFHGVTFVSLVS-AIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVML 519
Cdd:cd11511 397 ICYLLGLLLVTEGGMYIFQLFDYYAASGTCLLFlAIFEVICIGWVYGANRFYDNIEDMIGYRPWPLIKICWLVFTPGLCL 476
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24661428 520 VILVYSLLTMRPLSYNGQ-EFPLVYRVVGWCVSgciIGQLFYWAGYANFK--QPKGSLKSRINNSIKP 584
Cdd:cd11511 477 AVFLFSLIKYTPLKYNNSyVYPPWGYVLGWLMA---LSSMVCIPLYAIFIllKTKGSLKQRLMQLISP 541
SLC6sbd_SERT cd11513
Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain; SERT (also ...
51-584 4.33e-122

Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain; SERT (also called 5-HTT), is a transmembrane transporter that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The antiport of a K+ ion is believed to follow the transport of serotonin and promote the reorientation of SERT for another transport cycle. Human SERT is encoded by the SLC6A4 gene. SERT is expressed in brain, peripheral nervous system, placenta, epithelium, and platelets. SERT may play a role in diseases or disorders including anxiety, depression, autism, gastrointestinal disorders, premature ejaculation, and obesity. It may also have a role in social cognition. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271399  Cd Length: 537  Bit Score: 372.24  E-value: 4.33e-122
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVF-DFAPLM 129
Cdd:cd11513   1 RETWGKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLIPYTIMAIFGGIPLFYMELALGQYHRNGCISIWrKICPIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 130 RGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWGDGCVSASGGQPLQGQLSRNFSSSTQLYLQRIVL 209
Cdd:cd11513  81 KGIGYAICIIALYVASYYNTIIAWALYYLYSSFTDELPWTSCNNSWNTGNCTNYFAKDNITWTLHSTSPAEEFYTRHVLQ 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 210 NETDSLEEGIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWE 289
Cdd:cd11513 161 VHRSKGLGDLGGISWQLTLCLFLIFTIVYFSIWKGVKTSGKVVWVTATFPYIVLFILLVRGATLPGAWRGVVFYLKPNWQ 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 290 KLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGTKDIASV 369
Cdd:cd11513 241 KLLETGVWVDAAAQIFFSLGPGFGVLLALASYNKFNNNCYQDALVTSVVNCLTSFVSGFVIFTVLGYMAEMRNEDVSEVA 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 370 VKAGPGLAFISYPDAIAKFKMfPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNV---KLWIIVVSLSVIGFLVG 446
Cdd:cd11513 321 KDAGPSLLFITYAEAIANMPA-STFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVwskRREKFVLGLVIVCFLGS 399
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 447 LIYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSL 526
Cdd:cd11513 400 LATLTFGGAYVVKLLEEYATGPAVLTVVLLEAVAVSWFYGITQFCNDVKEMLGFSPGWFWRVCWVAISPLFLLFIICSFL 479
                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24661428 527 LTMRPLSYNGQEFPLVYRVVGWCVSGCIIGQLFYWAGYANFKQPkGSLKSRINNSIKP 584
Cdd:cd11513 480 MNPPQLRLFDYNYPYWSIVVGYCIGTSSIICIPIYMAYRLIITP-GTLKERIIKSITP 536
SLC6sbd_GAT2 cd11507
Na(+)- and Cl(-)-dependent GABA transporter 2; solute-binding domain; This family includes ...
51-587 1.43e-119

Na(+)- and Cl(-)-dependent GABA transporter 2; solute-binding domain; This family includes human GAT2 (hGAT2) which transports gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. hGAT2 is encoded by the SLC6A13 gene, and is similar to mouse GAT-3, and rat GAT2. hGAT2 is expressed in brain, kidney, lung, and testis. hGAT2 is a potential drug target for treatment of epilepsy. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271396  Cd Length: 544  Bit Score: 366.23  E-value: 1.43e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVF-DFAPLM 129
Cdd:cd11507   1 RGQWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTSQGGVTAWrKICPLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 130 RGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWGDG-CVSASGGQPLQGQLSRNFSSSTQLYLQRIV 208
Cdd:cd11507  81 EGIGYASQVIVMLLNCYYIIVLAWALFYLFSSFTIDLPWGSCGHEWNTEnCMEFQKANSTLNVTSENATSPVIEFWERRV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 209 LNETDSLEEgIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQW 288
Cdd:cd11507 161 LKISDGIQH-LGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVSLPGALQGIQFYLYPDL 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 289 EKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGTKdIAS 368
Cdd:cd11507 240 SRLQDPQVWMDAGTQIFFSYAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMAEEQGVP-ISE 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 369 VVKAGPGLAFISYPDAIAKFKMFPqVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNV-----KLWIIVVSLSVIGF 443
Cdd:cd11507 319 VAESGPGLAFIAYPRAVVMLPFSP-LWACFFFFMVVLLGLDSQFVCVESLVTALVDMYPTIfrkknRRELLILAVSIVSF 397
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 444 LVGLIYITPGGQHIITLMDFHGVTFVSLV-SAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVIL 522
Cdd:cd11507 398 LVGLIMLTEGGMYVFQLFDYYAASGMCLLfVAIFETLCVAWVYGADRFYDNIEDMIGYRPWAIIKYCWLFITPAVCMATF 477
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24661428 523 VYSLLTMRPLSYNGQ-EFPLVYRVVGWCVSGCIIGQLFYWAGYaNFKQPKGSLKSRINNSIKPHSD 587
Cdd:cd11507 478 LFSLIKYTPLTYNKKyVYPWWGDALGWLLALSSMVCIPLWVGY-KLSTIKGSLRERFRQLTCPDED 542
SLC6sbd_CT1 cd11509
Na(+)- and Cl(-)-dependent creatine transporter 1; solute-binding domain; CT1 (also called ...
51-584 3.24e-119

Na(+)- and Cl(-)-dependent creatine transporter 1; solute-binding domain; CT1 (also called CRTR, CRT) transports creatine. Human CT1 is encoded by the SLC6A8 gene. CT1 is ubiquitously expressed, with highest levels found in skeletal muscle and kidney. Creatine is absorbed from food or synthesized from arginine and plays an important role in energy metabolism. Deficiency in human CT1 leads to X-linked cerebral creatine transporter deficiency. In males, this disorder is characterized by language and speech delays, autistic-like behavior, seizures in about 50% of cases, and can also involve midfacial hypoplasia, and short stature. In females, it is characterized by mild cognitive impairment with behavior and learning problems. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271397  Cd Length: 589  Bit Score: 366.87  E-value: 3.24e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFAPLMR 130
Cdd:cd11509   1 RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYLLIAFVGGIPIFFLEIALGQFMKAGGINAWNIAPLFK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 131 GVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEW--------------GDGCVSASGGQPLQGQLSRNF 196
Cdd:cd11509  81 GLGYASMVIVFFCNTYYIMVLAWGFYYLVKSFTNTLPWATCGNPWntpncteifrhadcNNGASSAGSLANLTCDELANR 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 197 SSSTQLYLQRIVLNETDSLEEgIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGA 276
Cdd:cd11509 161 RSPVIEFWERKVLRLSGGLEE-PGALNWELTLCLLATWVLVYFCVWKGVKSTGKVVYFTATFPYVVLVVLLVRGVTLPGA 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 277 YDGVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGN 356
Cdd:cd11509 240 LDGIIYYLKPDWSKLGEAQVWIDAGTQIFFSYAIGLGALTALGSYNRFHNNCYKDAFILALINSGTSFFAGFVVFSILGF 319
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 357 LAHESGTkDIASVVKAGPGLAFISYPDAIAKFKmFPQVFSLLFFAMLFMLGVGSNV----GMVSCIMTVLKDQFVNVKLW 432
Cdd:cd11509 320 MASEQGV-DISKVAESGPGLAFIAYPKAVTLMP-VAPLWAALFFFMLLLLGLDSQFvgveGFITGILDLLPAKYYFRYQR 397
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 433 IIVVSLS-VIGFLVGLIYITPGGQHIITLMDFHGVTFVSLV-SAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICW 510
Cdd:cd11509 398 EVVVALCcLLCFLIDLSMVTEGGMYVFQLFDYYSASGTTLLwQAFWECVVVAWVYGADRFMDDIARMIGYRPLPWMKWCW 477
                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24661428 511 SIVTPLVMLVILVYSLLTMRPLSYNGQ-EFPLVYRVVGWCVS----GCIIGQLFYwagyaNFKQPKGSLKSRINNSIKP 584
Cdd:cd11509 478 SVITPLVCMGIFLFHVVNYKPLTYNKTyVYPWWGEAIGWCLAlssmLCIPLTVLY-----KLLRAKGSLKERWQKLTTP 551
SLC6sbd_DAT1 cd11514
Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain; DAT1 (also called ...
51-587 5.29e-119

Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain; DAT1 (also called DAT), is a plasma membrane transport protein that functions at the dopaminergic synapses to transport dopamine from the extracellular space back into the presynaptic nerve terminal. Human DAT1 is encoded by the SLC6A3 gene, and is expressed in the brain. DAT1 may play a role in diseases or disorders related to dopaminergic neurons, including attention-deficit hyperactivity disorder (ADHD), Tourette syndrome, Parkinson's disease, alcoholism, drug abuse, schizophrenia, extraversion, and risky behavior. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212083  Cd Length: 555  Bit Score: 365.02  E-value: 5.29e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFAPLMR 130
Cdd:cd11514   1 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLFFMVIAGMPLFYMELALGQFNREGAAGVWKICPIFK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 131 GVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWGD-GCVSASGGQPLQGQLSRNFSSST---QLYLQR 206
Cdd:cd11514  81 GVGFTVILISLYVGFFYNVIIAWALFYLFSSFTGELPWIHCNNSWNSpNCSDAHPGDSSGDSSGLNDTYKTtpaAEYFER 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 207 IVLNETDSleEGI---GYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYF 283
Cdd:cd11514 161 GVLHLHES--HGIhdlGPPRWQLTSCLVVVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIKAY 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 284 LTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGT 363
Cdd:cd11514 239 LSVDFLRLCEASVWIDAATQICFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFFSGFVVFSFLGYMAQKHNV 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 364 KdIASVVKAGPGLAFISYPDAIAKFKMfPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFV----NVKLWIIVVSLS 439
Cdd:cd11514 319 P-IGDVAKDGPGLIFIIYPEAIATLPL-SSVWAVIFFIMLLTLGIDSAMGGMESVITGLIDEFKflhrHRELFTLFIVLS 396
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 440 VigFLVGLIYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVML 519
Cdd:cd11514 397 T--FLISLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGIAWFYGVGRFSDDIEEMIGQRPGLYWRLCWKFVSPCFLL 474
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24661428 520 VILVYSLLTMRPLSYNGQEFPLVYRVVGWCVSGCIIGQLFYWAGYaNFKQPKGSLKSRINNSIKPHSD 587
Cdd:cd11514 475 FVVVVSIVTFRPPKYGSYIFPDWANMVGWCLAISSMAMVPLYAIY-KFCSLPGSFREKLAYAITPEKE 541
SLC6sbd_NET cd11512
Na(+)- and Cl(-)-dependent norepinephrine transporter NET; solute-binding domain; NET (also ...
51-587 6.68e-119

Na(+)- and Cl(-)-dependent norepinephrine transporter NET; solute-binding domain; NET (also called NAT1, NET1), is a transmembrane transporter that transports the neurotransmitter norepinephrine from synaptic spaces into presynaptic neurons. Human NET is encoded by the SLC6A2 gene. NET is expressed in brain, peripheral nervous system, adrenal gland, and placenta. NET may play a role in diseases or disorders including depression, orthostatic intolerance, anorexia nervosa, cardiovascular diseases, alcoholism, and attention-deficit hyperactivity disorder. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212081  Cd Length: 560  Bit Score: 365.05  E-value: 6.68e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFAPLMR 130
Cdd:cd11512   1 RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPCFK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 131 GVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWGDGcvSASGGQPLQGQLSRN--------FSSSTQL 202
Cdd:cd11512  81 GVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTSELPWTTCGNVWNSP--NCTDPKLLNASVLGNgtkyskykLTPAAEF 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 203 YLQRIV-LNETDSLEEgIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVM 281
Cdd:cd11512 159 YERGVLhLHESAGIHD-LGLPRWQLTLCLFVVVIVLFFSLWKGVKTSGKVVWITATLPYVVLFVLLIHGVTLPGAFNGIN 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 282 YFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHES 361
Cdd:cd11512 238 AYLHIDFKRLKEATVWIDAATQIFYSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEH 317
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 362 GTKdIASVVKAGPGLAFISYPDAIAKFKMfPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNVKLW--IIVVSLS 439
Cdd:cd11512 318 KVK-IEDVATEGAGLVFILYPEAISTLSG-STFWAVVFFIMLLTLGIDSSMGGMEAVITGLADDFSILKKHrkLFTFGVA 395
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 440 VIGFLVGLIYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVML 519
Cdd:cd11512 396 FITFLLALFCITNGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSDDIQQMMGFRPGLYWRLCWKFVSPAFLL 475
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24661428 520 VILVYSLLTMRPLSYNGQEFPLVYRVVGWCVSGCIIGQLFYWAGYaNFKQPKGSLKSRINNSIKPHSD 587
Cdd:cd11512 476 FVVIVSIINFKPLTYDDYNFPPWANRTGWGIALSSMLLVPIYVIY-KFFTVPGTFEERLAYCITPENE 542
SLC6sbd_ATB0 cd11501
Na(+)- and Cl(-)-dependent beta-alanine transporter ATB0+; solute-binding domain; ATB0+ (also ...
51-590 2.51e-118

Na(+)- and Cl(-)-dependent beta-alanine transporter ATB0+; solute-binding domain; ATB0+ (also known as the beta-alanine carrier) is a transmembrane transporter with a broad substrate specificity; it can transport non-alpha-amino acids such as beta-alanine with low affinity, and can transport dipolar and cationic amino acids such as leucine and lysine, with a higher affinity. It may have a role in the absorption of essential nutrients and drugs in the distal regions of the human gastrointestinal tract. Human ATB0+ is encoded by the SLC6A14 gene. ATB0+ is expressed in the lung, trachea, salivary gland, mammary gland, stomach, and pituitary gland. ATB0+ may play a role in obesity, and its upregulation may have a pathogenic role in colorectal cancer. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271391  Cd Length: 602  Bit Score: 364.97  E-value: 2.51e-118
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFAPLMR 130
Cdd:cd11501   1 RGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYKNGGGAFLIPYTIMLALAGLPLFFMECSLGQFASLGPISVWRILPLFQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 131 GVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCrEEWGDG----------CVSASGGQPLQGQLS----RNF 196
Cdd:cd11501  81 GVGITMVLISTFVAIYYNVIIAYSLYYLFASFQSELPWSDC-FSWADEncsktpivthCNVSTANNGIHENKSwvdiNNL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 197 S------------SSTQLYLQRIVLNETDSLEEgIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMF 264
Cdd:cd11501 160 TcingsiiyqpgqLPSEQYWNKVALQRSSGMDE-TGVIVWYLALCLLLSWIIVGAALFKGIKSSGKVVYFTALFPYVVLL 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 265 ILLVRALTLPGAYDGVMYFLTPQ--WEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFT 342
Cdd:cd11501 239 ILLVRGATLEGASDGIEYYIGAQsnITKLMEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFHNNCYSDAIVVCVTNCLT 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 343 SLLSGVIIFGILGNLAHESGtKDIASVVKAGPGLAFISYPDAIAKFKMFPqVFSLLFFAMLFMLGVGSNVGMVSCIMTVL 422
Cdd:cd11501 319 SVFAGFAIFSVLGHMAHVSG-RPVSEVVDSGFDLAFIAYPEALSKLPISP-LWSILFFFMLLTLGLDSQFASIETITTTI 396
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 423 KDQFVNV---KLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLN 499
Cdd:cd11501 397 QDAYPKVmkkMRIPITLGVCVILFLLGLVCVTQAGIYWVNLIDHFCAGWGILFAAVLELVGIIWIYGGNRFIEDIEMMIG 476
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 500 IKTSNY---YRICWSIVTPLVMLVILVYSLLTMRPLSYNGQEFPLVYRVVGWCVsgcIIGQLFYWAGYANFK--QPKGSL 574
Cdd:cd11501 477 AKSWIFwlwWRACWFFITPVLLIAILIWSLVTFHSPTYGSVPYPDWGTALGWCM---IIFCLIWIPIVAVIKiiKAKGNL 553
                       570
                ....*....|....*.
gi 24661428 575 KSRINNSIKPHSDWGP 590
Cdd:cd11501 554 FQRIKSCCRPTSNWGP 569
SLC6sbd_TauT cd11510
Na(+)- and Cl(-)-dependent taurine transporter; solute-binding domain; TauT is a Na(+)- and Cl ...
51-551 1.14e-111

Na(+)- and Cl(-)-dependent taurine transporter; solute-binding domain; TauT is a Na(+)- and Cl(-)-dependent, high-affinity, low-capacity transporter of taurine and beta-alanine. Human TauT is encoded by the SLC6A6 gene. TauT is expressed in brain, retina, liver, kidney, heart, spleen, and pancreas. It may play a part in the supply of taurine to the intestinal epithelium and in the between-meal-capture of taurine. It may also participate in re-absorbing taurine that has been deconjugated from bile acids in the distal lumen. Functional TauT protects kidney cells from nephrotoxicity caused by the chemotherapeutic agent cisplatin; cisplatin down-regulates TauT in a p53-dependent manner. In mice, TauT has been shown to be important for the maintenance of skeletal muscle function and total exercise capacity. TauT-/- mice develop additional clinically important diseases, some of which are characterized by apoptosis, including vision loss, olfactory dysfunction, and chronic liver disease. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271398  Cd Length: 542  Bit Score: 345.69  E-value: 1.14e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFD-FAPLM 129
Cdd:cd11510   1 REKWASKIDFLLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGGGLPVFFLEVALGQYTSEGGITCWEkLCPIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 130 RGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWGDGCVSAS---GGQPLQGQLS-RNFSSSTQLYLQ 205
Cdd:cd11510  81 TGIGYASIVIVSLLNIYYIVILAWALYYLFQSFQSELPWAHCNQKWNTPCCVEDtlrKNKTLWASINaTNFTSPVTEFWE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 206 RIVLNETDSLEEgIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLT 285
Cdd:cd11510 161 RNVLSLSAGIEH-VGTIKWDLALCLLLVWVVCFFCIWKGVKSTGKVVYFTATFPFLMLIVLLIRGVTLPGAAEGIKFYLY 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 286 PQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGTkD 365
Cdd:cd11510 240 PDITRLGDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNCYRDCLLLGCLNSGTSFVSGFAIFSVLGFMAQEQGV-D 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 366 IASVVKAGPGLAFISYPDAIAKFKMfPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQF-------VNVKLWIIVVSL 438
Cdd:cd11510 319 IADVAESGPGLAFIAYPKAVTMMPL-PTFWAILFFIMLLLLGLDSQFVEVEGQITSLVDLYpsflrkgYRREIFIAIVCF 397
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 439 svIGFLVGLIYITPGGQHIITLMDFHGVTFVSLV-SAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLV 517
Cdd:cd11510 398 --ISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLwVAFFECIAVAWVYGGDNMYDAIEDMIGYRPGPWMKYSWIVITPVL 475
                       490       500       510
                ....*....|....*....|....*....|....*
gi 24661428 518 MLVILVYSLLTMRPLSYNG-QEFPLVYRVVGWCVS 551
Cdd:cd11510 476 CVGCFIFSLVKYEPLTYNKvYVYPEWAIGLGWVLA 510
SLC6sbd_NTT4-like cd11515
Na(+)-dependent neurotransmitter transporter 4, and related proteins; solute-binding domain; ...
51-535 2.53e-108

Na(+)-dependent neurotransmitter transporter 4, and related proteins; solute-binding domain; This subgroup includes the solute-binding domain of NTT4 (also called XT1) and SBAT1 (also called B0AT2, v7-3, NTT7-3); both these proteins can transport neutral amino acids. Human SBAT1 is encoded by the SLC6A15 gene, a susceptibility gene for major depression. SBAT1 is expressed in brain, and may have a role in transporting neurotransmitter precursors into neurons. Human NTT4 is encoded by the SLC6A17 gene. NTT4 is specifically expressed in the nervous system, in synaptic vesicles of glutamatergic and GABAergic neurons, and may play an important role in synaptic transmission. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271400 [Multi-domain]  Cd Length: 530  Bit Score: 336.53  E-value: 2.53e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDF-APLM 129
Cdd:cd11515   1 RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLIVIGIPLFFLELSVGQRIRRGSIGVWNYiSPRL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 130 RGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCreewgdgcvsasggqPLQGQLSRNF-------SSSTQL 202
Cdd:cd11515  81 GGIGFASCVVCLFVALYYNVIIGWSLFYFSQSFQQPLPWDQC---------------PLVKNASHTFvepecekSSATTY 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 203 YLQRIVLNETDSLEEGIGYpSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMY 282
Cdd:cd11515 146 YWYREALNISDSISESGGL-NWKMTICLLAAWVIVCLAMIKGIQSSGKIMYFSSLFPYVVLICFLIRALLLNGSVDGIRH 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 283 FLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILG------- 355
Cdd:cd11515 225 MFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGfkiqkvk 304
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 356 ----NLAHESGTKDIASVVKA--GPGLAFISYPDAIAKFKMFPqVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFvNV 429
Cdd:cd11515 305 eeefPALHLNPCLIEDELNKAvqGTGLAFIAFTEAMTHFPASP-FWSVMFFLMLVNLGLGSMFGTIEGITTPIVDTF-KV 382
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 430 KLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRIC 509
Cdd:cd11515 383 RKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVAFVYGIDKFMEDLKDMLGFRPYRYYYYM 462
                       490       500
                ....*....|....*....|....*...
gi 24661428 510 WSIVTPLVMLVILVYSLLTM--RPLSYN 535
Cdd:cd11515 463 WKYISPLMLLSLLIASIVNMglSPPGYN 490
SLC6sbd_GAT3 cd11508
Na(+)- and Cl(-)-dependent GABA transporter 3; solute-binding domain; This family includes ...
51-551 5.85e-105

Na(+)- and Cl(-)-dependent GABA transporter 3; solute-binding domain; This family includes human GAT3 (hGAT3) a high-affinity transporter of gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. hGAT3 is encoded by the SLC6A11 gene, and is similar to mouse GAT4, and rat GAT3/GATB. GAT3 is expressed primarily in the glia of the brain, and is a potential drug target for antiepileptic drugs. This subgroup belongs to the solute carrier 6 (SLC6) transporter family


Pssm-ID: 212077  Cd Length: 542  Bit Score: 328.10  E-value: 5.85e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVF-DFAPLM 129
Cdd:cd11508   2 RGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWrKVCPLF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 130 RGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWG-DGCVSAS--GGQPLQGQLSRNFSSSTQLYLQR 206
Cdd:cd11508  82 EGIGYATQVIEAHLNVYYIIILAWAIFYLFNCFTTELPWATCGHEWNtENCVEFQklNSSNCSHVSLQNATSPVMEFWER 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 207 IVLNETDSLEEgIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTP 286
Cdd:cd11508 162 RVLAISDGIEH-IGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYP 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 287 QWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGTKdI 366
Cdd:cd11508 241 DLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVP-I 319
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 367 ASVVKAGPGLAFISYPDAIAKFKMFPqVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNV-----KLWIIVVSLSVI 441
Cdd:cd11508 320 AEVAESGPGLAFIAYPKAVTMMPLSP-LWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVfrrgyRRELLILALSIV 398
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 442 GFLVGLIYITPGGQHIITLMDFHGVTFVSLV-SAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLV 520
Cdd:cd11508 399 SYFLGLVMLTEGGMYIFQLFDSYAASGMCLLfVAIFECICIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWMVITPGICAG 478
                       490       500       510
                ....*....|....*....|....*....|..
gi 24661428 521 ILVYSLLTMRPLSYNG-QEFPLVYRVVGWCVS 551
Cdd:cd11508 479 IFIFFLVKYKPLKYNNvYTYPDWGYGIGWLMA 510
SLC6sbd_NTT4 cd11521
Na(+)-dependent neurotransmitter transporter 4; solute-binding domain; NTT4 (also called XT1) ...
51-529 8.33e-101

Na(+)-dependent neurotransmitter transporter 4; solute-binding domain; NTT4 (also called XT1) transports the neutral amino acids, proline, glycine, leucine, and alanine, and may play an important role in synaptic transmission. Human NTT4 is encoded by the SLC6A17 gene. NTT4 is specifically expressed in the nervous system, in synaptic vesicles of glutamatergic and GABAergic neurons. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271403 [Multi-domain]  Cd Length: 589  Bit Score: 318.85  E-value: 8.33e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDF-APLM 129
Cdd:cd11521   1 RPAWNSKLQYILAQIGYSVGLGNVWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWNYiCPRL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 130 RGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCrEEWGDGCVSAsggqpLQGQLSRnfSSSTQLYLQRIVL 209
Cdd:cd11521  81 GGIGYASCLVCFFVGLYYNVIIGWSIFYFFKSFQYPLPWSEC-PVVRNGSVAV-----VEAECEK--SSATTYFWYREAL 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 210 NETDSLEEGIGYpSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWE 289
Cdd:cd11521 153 DISNSISESGGL-NWKMTLCLLVAWSLVGMAMIKGIQSSGKVMYFSSLFPYVVLVCFLVRGLLLRGAVDGILHMFTPKLD 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 290 KLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILG-------------- 355
Cdd:cd11521 232 KMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGfkanimnekcvven 311
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 356 ----------------------NLAHESgTKDIASVVKA----------------------------GPGLAFISYPDAI 385
Cdd:cd11521 312 aekilgylntnvlshdlipphvNFSHLT-TKDYNEMYRVimtvkedhfkelgldaclledeldksvqGTGLAFIAFTEAM 390
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 386 AKFKMFPqVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFvNVKLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHG 465
Cdd:cd11521 391 THFPASP-FWSVMFFLMLINLGLGSMIGTMSGITTPIIDTF-KVRKEVFTVGCCIFAFLVGLIFVQRSGNYFVTMFDDYS 468
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24661428 466 VTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTM 529
Cdd:cd11521 469 ATLPLTVVVILENIAVAWIYGTKKFMQELTEMLGFRPYQFYFYTWKYVSPICMAVLMTASIIQL 532
SLC6sbd_SBAT1 cd11522
Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain; SBAT1 (also ...
51-535 1.44e-97

Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain; SBAT1 (also called B0AT2, v7-3, NTT7-3) is a high-affinity Na(+)-dependent transporter for large neutral amino acids, including leucine, isoleucine, valine, proline and methionine. Human SBAT1 is encoded by the SLC6A15 gene, a susceptibility gene for major depression. SBAT1 is expressed in brain, and may have a role in transporting neurotransmitter precursors into neurons. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212091 [Multi-domain]  Cd Length: 580  Bit Score: 310.31  E-value: 1.44e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDF-APLM 129
Cdd:cd11522   1 RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLVPYLILLLVIGIPLFFLELSVGQRIRRGSIGVWNYiSPKL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 130 RGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCreewgdgcvsasggqPLQGQLSRNF-------SSSTQL 202
Cdd:cd11522  81 GGIGFASCIVCFFVALYYNVIIGWSLFYFSQSFQQPLPWDQC---------------PLVKNASHTFvepecekSSATTY 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 203 YLQRIVLNETDSLEEGIGYpSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMY 282
Cdd:cd11522 146 YWYREALNISSSISESGGL-NWKMTICLLAAWVMVCLAMIKGIQSSGKIMYFSSLFPYVVLICFLIRALLLNGSVDGIRH 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 283 FLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAH--- 359
Cdd:cd11522 225 MFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKANvin 304
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 360 ----ESGTKDIASVVKA--------------------------------------------------------GPGLAFI 379
Cdd:cd11522 305 ekciIQNSEKIIKLLKMgnlsqdiiphhinfssitaedynlvydiiqkvkeeefpalglkscqiedelnkavqGTGLAFI 384
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 380 SYPDAIAKFKMFPqVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFvNVKLWIIVVSLSVIGFLVGLIYITPGGQHIIT 459
Cdd:cd11522 385 AFTEAMTHFPASP-FWSVMFFLMLVNLGLGSMFGTIEGIITPIVDTF-KVRKEILTVICCLLAFCIGLIFVQRSGNYFVT 462
                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24661428 460 LMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTM--RPLSYN 535
Cdd:cd11522 463 MFDDYSATLPLLIVVILENIAVSFVYGIDKFMEDLKDMLGFTPNRYYYYMWKYISPLVLLSLLVASVVQMglSPPGYN 540
SLC6sbd_u1 cd10334
uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; SLC6 ...
51-528 1.15e-94

uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, involved in regulating neurotransmitter signaling and homeostasis, and the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter.


Pssm-ID: 271366 [Multi-domain]  Cd Length: 480  Bit Score: 299.41  E-value: 1.15e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVF-DFAPLM 129
Cdd:cd10334   1 REQWGSRAGFILAAIGSAVGLGNIWRFPYVAYENGGGAFLIPYLIALLTAGIPLLILEYGLGHKYRGSAPLAFrRLNKKF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 130 RGVGYAQLLALGVLATYYASVMALTLRYFFDSFAselpwsfcrEEWGDGcvsasggqplqgqlsrnfsssTQLYLQRIVL 209
Cdd:cd10334  81 EWIGWWQVLVAFVIATYYAVIIAWALSYLFFSFT---------LAWGDD---------------------PEAFFFGDFL 130
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 210 NETDSLEEGIGYPSGSLALMLGIsWLTVTLIIIRGVKSS-GKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQW 288
Cdd:cd10334 131 QLSDSPFDLGGIVWPILIALVLV-WLIIWFILYRGVKKGiEKASKIFMPLLFVLFLILVIRALTLPGAADGLNALFTPDW 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 289 EKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGTkDIAS 368
Cdd:cd10334 210 SALLDPKVWIAAYGQIFFSLSLGFGIMITYASYLPKKSDLTNNALITAFANSGFEILAGIGVFSILGFMAQAQGV-PVSE 288
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 369 VVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQF-VNVKLWIIVVslSVIGFLVGL 447
Cdd:cd10334 289 VVSSGIGLAFVAFPKAINLMPPLGALFGVLFFLSLVFAGLTSLISLVEVVISAVQDKFgLSRKKAVTIV--CLVGFLVSL 366
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 448 IYITPGGQHIITLMDfHGVTFVSLV-SAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSL 526
Cdd:cd10334 367 LFATGAGLYLLDIVD-HFINNYGIVlVGLVEVIVVGWVFGAEKLREHLNAVSDFKVGKWWDFLIKVVTPLVLGYMLILGL 445

                ..
gi 24661428 527 LT 528
Cdd:cd10334 446 IG 447
SLC6sbd_SIT1 cd11518
Na(+)- and Cl(-)-dependent imino acid transporter SIT1; solute-binding domain; SIT1 (also ...
49-526 6.03e-92

Na(+)- and Cl(-)-dependent imino acid transporter SIT1; solute-binding domain; SIT1 (also called XTRP3, XT3, IMINO) transports imino acids, such as proline, pipecolate, MeAIB, and sarcosine. It has weak affinity for neutral amino acids such as phenylalanine. Human SIT1 is encoded by the SLC6A20 gene. SIT1 is expressed in brain, kidney, small intestine, thymus, spleen, ovary, and lung. SLC6A20 is a candidate gene for the rare disorder iminoglycinuria. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271401 [Multi-domain]  Cd Length: 576  Bit Score: 295.33  E-value: 6.03e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  49 KARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVF-DFAP 127
Cdd:cd11518   2 KTRPLWDNPLQFVFACISYAVGLGNVWRFPYLCQMYGGGGFLIPYLIMLILEGMPLLYLELAVGQLMRQGSIGAWkSISP 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 128 LMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCreewgdgcvsasggqPLQGQLSR-----NFSSSTQL 202
Cdd:cd11518  82 YLGGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSNC---------------PLNSNHTAyneecEKASPTQY 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 203 YLQRIVLNETDSLEEGiGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMY 282
Cdd:cd11518 147 FWYRKTLNISPSILEN-GGIQWELAVCLILAWLVVYLCILRGTESTGKVVYVTALIPYLVLLIYLIRGLTLHGAANGLAY 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 283 FLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILG------- 355
Cdd:cd11518 226 MFTPKLEQLANPKTWINAATQIFFSLGLGFGSLIAFASYNEPSNNCERHAIIVSLINSGTSIFASIVTFSIYGfkatfny 305
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 356 ----------------------------------NLAHESGTKDIASVVK------------AGPGLAFISYPDAIAKFK 389
Cdd:cd11518 306 encmkkvillltntfdleegsvttenlgdmknylASAFPQEYSSIVPQIKncslekeldtavQGTGLAFIVYTEAIKNME 385
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 390 MfPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKD-QFVNVKLWIIVVS--LSVIGFLVGLIYITPGGQHIITLMDFHGV 466
Cdd:cd11518 386 V-SQLWSVLYFLMLLMLGIGSMLGNTAAILTPLTDsKFISSHLPKEAISglLCFTNCIIGLVFTMEAGNYWFDIFNDYAA 464
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 467 TFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSL 526
Cdd:cd11518 465 TLSLLLIVLVETIAVCYVYGLRRFENDLEAMTGHKLSWYWKIMWAFVSPLLIVSLFIFYL 524
SLC6sbd_B0AT3 cd11517
glycine transporter, B0AT3; solute-binding domain; B0AT3 (also called Xtrp2, XT2) transports ...
51-555 2.45e-90

glycine transporter, B0AT3; solute-binding domain; B0AT3 (also called Xtrp2, XT2) transports glycine. Human B0AT3 is encoded by the SLC6A18 gene. B0AT3 is expressed in the kidney. Mutations in the SLC6A18 gene may contribute to the autosomal recessive disorder iminoglycinuria and its related disorder hyperglycinuria. SLC6A18 or its neighboring genes are associated with increased susceptibility to myocardial infarction. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212086 [Multi-domain]  Cd Length: 576  Bit Score: 291.33  E-value: 2.45e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFD-FAPLM 129
Cdd:cd11517   2 RPKWDNKAQYLLSCIGFAVGLGNIWRFPYLCQTYGGGAFLIPYFIALVFEGIPLFHLELAIGQRLRKGSIGVWTtISPYL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 130 RGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFC-----REEWGDGCVSasggqplqgqlsrnfSSSTQLYL 204
Cdd:cd11517  82 GGVGLGCVTVSFLVSLYYNTILAWVLWYFLNSFQHPLPWSSCpldlnRTGFVEECQG---------------STAVSYFW 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 205 QRIVLNETDSLEEGiGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFL 284
Cdd:cd11517 147 YRQTLNITPDINDS-GSIQWWLLLCLAACWAIVYLCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATEGLIYLF 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 285 TPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILG--------- 355
Cdd:cd11517 226 TPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNPPRNDCEKDAVTIALVNSMTSLYASIPVFSVLGfkatndyeh 305
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 356 -------------NLAHESGTKD----------------IASV-------------VKAGPGLAFISYPDAIAKFKMfPQ 393
Cdd:cd11517 306 cldrnilslinefDFPEQSISRDnypsvlmhlnatwperVAQLplkaclledfldkSASGPGLAFIVFTEAVLHMPG-AQ 384
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 394 VFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVnVKLWIIVVSLS----VIGFLVGLIYITPGGQHIITLMDFHGVTFV 469
Cdd:cd11517 385 VWAVLFFGMLFTLGLSSMFGNVEGVITPLLDVGV-LPRWVPKEALTglvcLVCFLSALCFTLQSGNYWLEIFDSFAASLN 463
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 470 SLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILV--YSLLTMRPLSYNG-----QEFPLV 542
Cdd:cd11517 464 LLVIAFFEVVGVVYVYGIKRFCDDIEWMTGRRPSLYWRLTWRVVSPLLLLTIFVayIILLFQKPPSYKAwnpkyELFPSR 543
                       570
                ....*....|....*
gi 24661428 543 YRVV--GWCVSGCII 555
Cdd:cd11517 544 EEKLypGWVQAICVL 558
YocR COG0733
Na+-dependent transporter, SNF family [General function prediction only];
49-526 1.69e-86

Na+-dependent transporter, SNF family [General function prediction only];


Pssm-ID: 440497 [Multi-domain]  Cd Length: 444  Bit Score: 276.98  E-value: 1.69e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  49 KARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFA-- 126
Cdd:COG0733   3 SKREQWSSRLGFILAAAGSAVGLGNIWRFPYVAGENGGGAFLLPYLLALLLIGIPLLIAEFAIGRRGRKSPVGAFRKLap 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 127 -PLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASElpwsfcreeWGDGCVSASGGQplqgqlsrnfssstqlylq 205
Cdd:COG0733  83 gKKWEWIGWLGVLGAFLILSYYSVVAGWVLAYLFKSLTGA---------FGGLDAEDAGAF------------------- 134
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 206 rivlnetdsLEEGIGYPSGSLALMLgISWLTVTLIIIRGVKSS-GKAAYVL--ALFpyVVMFILLVRALTLPGAYDGVMY 282
Cdd:COG0733 135 ---------FGAFLSSPGEVLIWHL-LFLLLTALIVARGVQKGiEKASKILmpLLF--VLLIILVIRALTLPGAAEGLKF 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 283 FLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESG 362
Cdd:COG0733 203 LFTPDFSKLTDPEVWLAALGQAFFSLSLGMGIMITYGSYLPKDEDLPRSALIVALLDTLVALLAGLAIFPAVFAFGLEPA 282
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 363 tkdiasvvkAGPGLAFISYPDAIAkfKM-FPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFvNVKLWIIVVSLSVI 441
Cdd:COG0733 283 ---------AGPGLAFVTLPAVFA--QMpGGRLFGVLFFLLLLFAALTSAISLLEVVVAALIDKF-GLSRKKATLIVGLL 350
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 442 GFLVGLIYIT------PGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTP 515
Cdd:COG0733 351 IFLLGIPSALsfnvsvTIGLTFFDLVDFLVSNILLPLGGLLIAIFVGWVLGKEKLREELNAGSDIKLGKWWRFLIRYVAP 430
                       490
                ....*....|.
gi 24661428 516 LVMLVILVYSL 526
Cdd:COG0733 431 VALLIIFLNGL 441
SLC6sbd_B0AT1 cd11516
Na(+)-dependent neutral amino acids transporter, B0AT1; solute-binding domain; B0AT1 (also ...
51-528 2.56e-83

Na(+)-dependent neutral amino acids transporter, B0AT1; solute-binding domain; B0AT1 (also called HND) transports neutral amino acids. Human B0AT1 is encoded by the SLC6A19 gene. B0AT1 is expressed primarily in the kidney and intestine; it requires collectrin for expression in the kidney, and angiotensin-converting enzyme 2 for expression in the intestine. Interaction with these two proteins implicates B0AT1 in more complex processes such as glomerular structure, exocytosis, and blood pressure control. The autosomal recessive disorder, Hartnup disorder, is caused by mutations in B0AT1. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212085 [Multi-domain]  Cd Length: 581  Bit Score: 272.92  E-value: 2.56e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFD-FAPLM 129
Cdd:cd11516   1 RPKWDNKAQYMLTCVGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVFEGIPLLHLEFAIGQRLRKGSVGVWStIHPTL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 130 RGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFC-----REEWGDGCVSasggqplqgqlsrnfSSSTQLYL 204
Cdd:cd11516  81 KGVGIASMCVSFLVSLYYNTIIAWVMWYFFNSFQEPLPWSQCplnenRTGYIPECAK---------------SSPVDYFW 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 205 QRIVLNETDSLEEGiGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFL 284
Cdd:cd11516 146 YRETLNTSTSIDDS-GGIQWWMVLCLACAWGVLYVCTIRGIETTGKAVYVTSTLPYLVLTIFLIRGLTLKGSVNGIKFLF 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 285 TPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHES--- 361
Cdd:cd11516 225 TPDINELANPVTWLDAGAQVFYSFSLAFGGLISFSSYNSVHNNCEKDAVIISVINGFTSIYAATVIYSIIGFRATERfdd 304
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 362 -GTKDIASVVKA-----------------------------------------------GPGLAFISYPDAIAKFKMFPq 393
Cdd:cd11516 305 cFDGNILTLINAfdlpegnitqdnyqdmqqslnstdpdiisslslqtcdlnnflsegveGTGLAFIVFTEAITKMPLSP- 383
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 394 VFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNVKLW---IIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVS 470
Cdd:cd11516 384 LWSVLFFIMLFCLGLSSMFGNMEGVLVPLQDLKVIPKSWpkeIITGLICLVSFLIGLIFVLGSGNYWLALFDSFAGSIPL 463
                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24661428 471 LVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLT 528
Cdd:cd11516 464 LIIAFCEMFSVVYVYGIDRFNKDIEFMIGHKPNIFWQATWRVISPLIMLVIFLFYFVV 521
SLC6sbd_NTT5 cd11502
Neurotransmitter transporter 5; solute-binding domain; Human NTT5 is encoded by the SLC6A16 ...
54-534 2.38e-79

Neurotransmitter transporter 5; solute-binding domain; Human NTT5 is encoded by the SLC6A16 gene. NTT5 is expressed in testis, pancreas, and prostate; its expression is predominantly intracellular, indicative of a vesicular location. Its substrates are unknown. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271392  Cd Length: 535  Bit Score: 261.21  E-value: 2.38e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  54 WGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDF-APLMRGV 132
Cdd:cd11502   4 WSKKTEYILAQVGFSVGLSSIWRFPYLWHHNGGGSFLLIYILMLFLVGIPLLFLEMAVGQRLRQGSIGVWKIlSPWLGGV 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 133 GYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCreewgdgcvsasggqPLQGQLSRN-----FSSSTQLYLQRI 207
Cdd:cd11502  84 GYSSFLVCFIVGLYNNVLNSWSLFYLSQSFQFPLPWEKC---------------PLVKNSSDFdpecaRTTPSQYFWYRQ 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 208 VLNETDSLEEGiGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQ 287
Cdd:cd11502 149 TLKASDRIEDG-GVLVLSLTLSLFLAWCLLCVFMINGLKSTGKMLYVLVLLPYIILLCFLIRTLFLEGAKFGLKHLLVAK 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 288 WEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLA--------- 358
Cdd:cd11502 228 VSALYSLSVWRQAGGQVLYSLGLGFGTIISFSSYMPRSNNCLKDAFLVALVNLVTSLLTTPFIFAVLGFWAtpasiylsw 307
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 359 -------------HESGTKDIA---SVVKAGPGLAFISYPDAIAKFKMfPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVL 422
Cdd:cd11502 308 lnnlpqhiksqvlSKVPECSIQkqkEKIMEGPGFAFLAFSEAISLFPG-SSFWSILFFLMLLILGLSTMLGIMQGIITPL 386
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 423 KDQFVNVKLW--IIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNI 500
Cdd:cd11502 387 QDTFSFFRKHpkLLTVGVCLLMFLCSLIFTRPSGSYYVSLLDDYWVPMPIIFIVICENLAVAWAYGAKRFLADLMILLGH 466
                       490       500       510
                ....*....|....*....|....*....|....*.
gi 24661428 501 KTSNYYRICWSIVTPLVMLVILVYSL--LTMRPLSY 534
Cdd:cd11502 467 PISPIFTWLWCYLTPVVLLVLFTITLiqLYVKPITY 502
SLC6sbd_u2 cd11554
uncharacterized eukaryotic solute carrier 6 subfamily; solute-binding domain; SLC6 proteins ...
52-490 6.27e-73

uncharacterized eukaryotic solute carrier 6 subfamily; solute-binding domain; SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, and are involved in regulating neurotransmitter signaling and homeostasis, and are the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter.


Pssm-ID: 212092 [Multi-domain]  Cd Length: 406  Bit Score: 240.30  E-value: 6.27e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  52 DNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFD-FAPLMR 130
Cdd:cd11554   1 DQWGSRTAFVLAAMGGAVGLGNLLRFPSVVYNNGGLQFFIPYLLALVLLAIPILILELALGQAYRGGCVKAFNlINRRAK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 131 GVGYAQLLALGVLATYYASVMALTLRYFFDSFaselpwsfcreewgdgcvsasggqplqgqlsrnfssstqlylqrivln 210
Cdd:cd11554  81 GVGAAVVFGGFVVCTYYVPILAWIMVYFRHSF------------------------------------------------ 112
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 211 etdsleegigypsgsLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQW-E 289
Cdd:cd11554 113 ---------------TVGWLAFTWFVVWLCVFRGVGSTGRVVYITMGLPIVLIIILLGRGASLPNAGDGIRLYFATWRgD 177
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 290 KLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHesgTKDIASV 369
Cdd:cd11554 178 KLASGEIWQAAAGQVFFSTGVGFGYMTAYASYNSKFSNAVQDALIIAGSNSLFEIIAGFAVFGIVGYLGM---TPGVEGE 254
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 370 VKAGPGLAFISYPDAIAKFKMfPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFV--NVKLWIIVVSLSVIGFLVGL 447
Cdd:cd11554 255 ALGGFVLGFVTYPEAIAQMPG-SNFFAVLFFLTLFLLGISSAFALLEAVVTLICDSGWgrKVKRWWIATVVCFVSFLLSL 333
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....
gi 24661428 448 IYITPGGQHIITLMDFHgVTFVSLV-SAIFELIAVGWIYGTKRL 490
Cdd:cd11554 334 PYCTRFGYYLLDAVDAW-ISNVALVfVVWAECVAATTVYRFEDV 376
SLC6sbd_Tyt1-Like cd10336
solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; SLC6 ...
52-526 1.57e-70

solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, involved in regulating neurotransmitter signaling and homeostasis, and the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter. An arrangement of 12 transmembrane (TM) helices appears to be as a common topological motif for eukaryotic and some prokaryotic and archaeal NTTs. However, this subfamily which contains the majority of bacterial members and some archaeal members, appears to contain only 11 TMs; for example the functional Fusobacterium nucleatum tyrosine transporter Tyt1.


Pssm-ID: 271367 [Multi-domain]  Cd Length: 440  Bit Score: 234.64  E-value: 1.57e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  52 DNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFA----P 127
Cdd:cd10336   1 EQWSSRLGFILAAAGSAVGLGNIWRFPYLAGENGGGAFLLVYLLFVLLIGLPLLIAEFAIGRRTRKNPVGAFAKLagggK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 128 LMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELpwsfcreewgdgcvsaSGGQPlqGQLSRNFSSStqlylqri 207
Cdd:cd10336  81 KWKLIGWLGVLGGFLILSFYSVVGGWVLKYLFKSLTGLF----------------AGADA--AEVGAAFFGF-------- 134
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 208 vlnetdsleegIGYPSGSLALMLGISWLTVtLIIIRGVKSS-GKAAYVL--ALFpyVVMFILLVRALTLPGAYDGVMYFL 284
Cdd:cd10336 135 -----------IASPLSPLLWHLLFLLLTA-LIVARGVKKGiERANKILmpLLF--ILLIILAIRSLTLPGAGEGLKFLL 200
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 285 TPQWEKLLePQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGtk 364
Cdd:cd10336 201 KPDFSKLT-PEVVLAALGQAFFSLSLGMGVMITYGSYLSKDENLPKSALIVAVLDTLVALLAGLVIFPAVFAFGLDPA-- 277
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 365 diasvvkAGPGLAFISYPDAIAkfKM-FPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFV---NVKLWIIVVSLSV 440
Cdd:cd10336 278 -------AGPGLLFITLPAVFA--QMpGGRLFGILFFLLLLFAALTSAISLLEVVVAYLIDEFGwsrKKATLIVGIIIFL 348
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 441 IGFLVGL-----IYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAE-YMLNIKTSNYYRICWSIVT 514
Cdd:cd10336 349 LGIPSALsfgvlSDVTIFGKTFFDLLDFLVSNILLPLGGLLIAIFVGWVLGKEALLEELNkGGLGKKLFKIWLFLLRYVA 428
                       490
                ....*....|..
gi 24661428 515 PLVMLVILVYSL 526
Cdd:cd10336 429 PVAILIIFLLGL 440
SLC5-6-like_sbd cd06857
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
58-523 9.27e-47

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


Pssm-ID: 271356 [Multi-domain]  Cd Length: 407  Bit Score: 169.84  E-value: 9.27e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  58 LEFLMSCIALSVGLGNVWRFPFTALENGGGaFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFAPLMRGVGYAQL 137
Cdd:cd06857   1 FDLILACIGLALGLANFIRFPQMTYSYGGA-FILPYIVLSIIVGIPLLVLELSMGQFSGIGFISMWRCSPFFKGLGVVSL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 138 LALGVLATYYASVMALTLRYFfdsfaselpwsfcreewgdgcvsasggqplqgqlsrnfssstqlylqrivlnetdslee 217
Cdd:cd06857  80 FLSFLLLIYYTYLAALALVYI----------------------------------------------------------- 100
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 218 gIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLP--GAYDGVMYFLTPQWEKLLEPQ 295
Cdd:cd06857 101 -INLYYWILALGLFLIWVTIYGIFFRGLKSIGKLIVIAVIVLLVLLLVLTVRALFLEgaGASEGLNKGGTPDFMELNNSG 179
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 296 VWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGTKDIASVVkAGPG 375
Cdd:cd06857 180 IWTAATIQVFFSLGAGWGSVITIASFCLFKKNAQRDALIAAFLNLIASIIFVGLIGIAAGVLSFDPQNMVVLGLL-NSLY 258
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 376 LAFISYPDAIaKFKMFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNVKLWIIVVSLSVIGFLVGLIYITPGGQ 455
Cdd:cd06857 259 LTFIASPQAI-SSLAGSNLWAFLYYAALLLAGLSSMATITNTVAQSLFDEFRRKLKTGVIDTALIVVLLVAAVIFLVLGL 337
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24661428 456 HIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVtPLVMLVILV 523
Cdd:cd06857 338 RILFLTDKQLVGTSVVPLLLILLLVVFWIYGRERIQRDIEFMLGPVGSIVWFWLWVIA-PAILVIILV 404
LeuT-like_sbd cd10333
Aquifex aeolicus LeuT and related proteins; solute binding domain; LeuT is a bacterial amino ...
51-527 2.45e-46

Aquifex aeolicus LeuT and related proteins; solute binding domain; LeuT is a bacterial amino acid transporter with specificity for the hydrophobic amino acids glycine, alanine, methionine, and leucine. This subgroup belongs to the solute carrier 6 (SLC6) transporter family; LeuT has been used as a structural template for understanding fundamental aspects of SLC6 function. It has an arrangement of 12 transmembrane helices (TMs), which appears to be a common motif for eukaryotic and some prokaryotic and archaeal SLC6s: an inverted topology repeat: TMs1-5 and TMs6-10, and TMs11-12.


Pssm-ID: 271365 [Multi-domain]  Cd Length: 496  Bit Score: 170.96  E-value: 2.45e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428  51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQF-------SSRGIVQVF 123
Cdd:cd10333   1 REHWGSRIGLILAMAGNAVGLGNFLRFPVQAAQNGGGAFMIPYFIAFLLLGIPLMWIEWAMGRYggkyghgTTPMIFLLA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 124 DFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFaselpwsfcreewgdgcvsaSGGQPLQGQLSRNFSSSTQLY 203
Cdd:cd10333  81 WENRFAKILGAIGLAIPLLVNSYYVYIESWTLGYAFKSL--------------------TGAYPEPPSILRPTAEFFYSY 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 204 lqrivlnetdsleegIGYPSGSLALMLGISWLTVTLIIIRGVkSSGKAAYVLALFP--YVVMFILLVRALTLP------- 274
Cdd:cd10333 141 ---------------IGKPSGLAYIFFLITMALNFFILYRGV-SKGIEAFAKIAMPllYVFAIILLIRVLTLGspvnpnw 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 275 GAYDGVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVII---- 350
Cdd:cd10333 205 TALKGLNFLWNPDFSKLKNPKVWLAAAGQIFFTLSLGMGIIQNYASYLKKDDDVVLSGLTAASLNEFAEVILGGSIaipa 284
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 351 -FGILGnlahesgtKDIASVVKAGPGLAFISYPDAiakFKMFP--QVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQF- 426
Cdd:cd10333 285 aFAFLG--------VAVAIAKAGGFGLGFIALPNV---FSQMPggQFFGFLWFLLLFFAGITSSIAMYQPLIAFLEEELg 353
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24661428 427 --VNVKLWIIVVSLSVIGFLVGLIYitpgGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSN 504
Cdd:cd10333 354 isRKHAAWVVFAIVFFLGLPVVLEF----DLKALDELDFWVGTILLVILGLIEIIVFGWIFGAKKGWEEINRGALIKVPR 429
                       490       500
                ....*....|....*....|...
gi 24661428 505 YYRICWSIVTPLVMLVILVYSLL 527
Cdd:cd10333 430 FYKYVMKYITPAFLAVVLVFWTI 452
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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