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Conserved domains on  [gi|21355675|ref|NP_648268|]
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Valyl-tRNA synthetase, mitochondrial, isoform A [Drosophila melanogaster]

Protein Classification

valine--tRNA ligase( domain architecture ID 1000888)

valine--tRNA ligase catalyzes the attachment of valine to tRNA(Val)

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PTZ00419 super family cl36560
valyl-tRNA synthetase-like protein; Provisional
23-989 0e+00

valyl-tRNA synthetase-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00419:

Pssm-ID: 240411 [Multi-domain]  Cd Length: 995  Bit Score: 966.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   23 YSLYYSTLKDA-ANELPLAAGYQPQPVEN---AYWERE--HRQANLPKASASSCKrgtYRMLLPPPNVTGNLHLGHALMA 96
Cdd:PTZ00419   7 IKLSKDEKKNKkRNISSMAASYDPKEVESgwyEWWEKSgfFKPAEDAKSLNSGKK---FVIVLPPPNVTGYLHIGHALTG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   97 TVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQAKTRHELGRSAFLDEVWRWKAEKGAGIVQDLRQLGCKL 176
Cdd:PTZ00419  84 AIQDSLIRYHRMKGDETLWVPGTDHAGIATQVVVEKKLMKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  177 NWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTALRSAISDIEVDSVEITEPVEISVPGYDHKVLFGRMYDF 256
Cdd:PTZ00419 164 DWSREVFTMDEQRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEKPTKITIPGYDKKVEVGVLWHF 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  257 AYHVVDGEAlpdgsvEEIVVSTTRPETILGDVAVAVHPLDPRYAKYRNidqVKLKHPF-RDDTIPLVFD-ITVDQEFGTG 334
Cdd:PTZ00419 244 AYPLEDSGQ------EEIVVATTRIETMLGDVAVAVHPKDERYKKLHG---KELIHPFiPDRKIPIIADdELVDMEFGTG 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  335 AVKITPAHDKFDFELATRHKLEPRQVFTETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKD 414
Cdd:PTZ00419 315 AVKITPAHDPNDYEIAKRHNLPFINIFTLDGKINENGGEFAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGD 394
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  415 VIEYMILPQWFLKCKDLAKDALSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAYEVI------DSQGN 488
Cdd:PTZ00419 395 IVEPMLIPQWYVNCKDMAKRAVEAVRNGELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYRVIskgpetDPSDE 474
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  489 SQWVAALDEKTARQKAMRLIG--SEEFTLKRDPDVLDTWFSSSLLPFSTAGWPEES--YKERYPLDIMQTGHDIIFFWVA 564
Cdd:PTZ00419 475 EPWVVARSEEEALEKAKKKFGlsEEDFELEQDEDVLDTWFSSGLFPFSTLGWPDQTddLQRFFPTSLLETGSDILFFWVA 554
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  565 RMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSKSIGNIVAPQQVVQGASLESLKAGLEQsceaGIITPSELKASTIGMT 644
Cdd:PTZ00419 555 RMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLNQKLYE----GNLPEKEIKRAIELQK 630
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  645 QMFPNGIQECGTDALRFTLMSHNIKSHFISFDVNACHTNKLFLNKVWQAMRFTLGSAKGL--GISLHQFETLEGVNLGLW 722
Cdd:PTZ00419 631 KEFPNGIPECGTDALRFGLLAYTQQGRNINLDINRVVGYRHFCNKLWNAVKFALMKLLKDfnLPNSTLFKPNNVESLPWE 710
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  723 DRWIVGRLAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETTKPAIG--NRSADAYIHVGTLTACLSWGLQAMAP 800
Cdd:PTZ00419 711 DKWILHRLNVAIKEVTEGFKEYDFSEATQATYNFWLYELCDVYLELIKPRLSkqSDGERKQHAQDVLHTVLDIGLRLLHP 790
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  801 YAPFVASELLQHVPLNIELKLS-----------DYKDEKLEEEVNEIVNICHNVRQVKSRNEISKRHHPQLSLFAQNTDS 869
Cdd:PTZ00419 791 MMPFITEELYQRLPNYLRKSESisiakypqpnpGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAKDAEL 870
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  870 EGVLRRHLPQIKVLSRCEDVELELFDESSKISKQLSYFSTAGALCSFGLKLSDGLDLTPE------KRDEMQKAnakklk 943
Cdd:PTZ00419 871 IELIESAENLISTLAKIGSVSVIPPIEEEAEVPKGCGFDVVDNKVIIYLNLDEFIDLKKElaklekKLAKLQKS------ 944
                        970       980       990      1000
                 ....*....|....*....|....*....|....*....|....*.
gi 21355675  944 klvteLQRYRMRLDNEAFQLMADKKVKSHFENKVKELEAEINSLTR 989
Cdd:PTZ00419 945 -----LESYLKKISIPNYEDKVPEDVRKLNDEKIDELNEEIKQLEQ 985
 
Name Accession Description Interval E-value
PTZ00419 PTZ00419
valyl-tRNA synthetase-like protein; Provisional
23-989 0e+00

valyl-tRNA synthetase-like protein; Provisional


Pssm-ID: 240411 [Multi-domain]  Cd Length: 995  Bit Score: 966.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   23 YSLYYSTLKDA-ANELPLAAGYQPQPVEN---AYWERE--HRQANLPKASASSCKrgtYRMLLPPPNVTGNLHLGHALMA 96
Cdd:PTZ00419   7 IKLSKDEKKNKkRNISSMAASYDPKEVESgwyEWWEKSgfFKPAEDAKSLNSGKK---FVIVLPPPNVTGYLHIGHALTG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   97 TVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQAKTRHELGRSAFLDEVWRWKAEKGAGIVQDLRQLGCKL 176
Cdd:PTZ00419  84 AIQDSLIRYHRMKGDETLWVPGTDHAGIATQVVVEKKLMKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  177 NWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTALRSAISDIEVDSVEITEPVEISVPGYDHKVLFGRMYDF 256
Cdd:PTZ00419 164 DWSREVFTMDEQRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEKPTKITIPGYDKKVEVGVLWHF 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  257 AYHVVDGEAlpdgsvEEIVVSTTRPETILGDVAVAVHPLDPRYAKYRNidqVKLKHPF-RDDTIPLVFD-ITVDQEFGTG 334
Cdd:PTZ00419 244 AYPLEDSGQ------EEIVVATTRIETMLGDVAVAVHPKDERYKKLHG---KELIHPFiPDRKIPIIADdELVDMEFGTG 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  335 AVKITPAHDKFDFELATRHKLEPRQVFTETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKD 414
Cdd:PTZ00419 315 AVKITPAHDPNDYEIAKRHNLPFINIFTLDGKINENGGEFAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGD 394
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  415 VIEYMILPQWFLKCKDLAKDALSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAYEVI------DSQGN 488
Cdd:PTZ00419 395 IVEPMLIPQWYVNCKDMAKRAVEAVRNGELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYRVIskgpetDPSDE 474
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  489 SQWVAALDEKTARQKAMRLIG--SEEFTLKRDPDVLDTWFSSSLLPFSTAGWPEES--YKERYPLDIMQTGHDIIFFWVA 564
Cdd:PTZ00419 475 EPWVVARSEEEALEKAKKKFGlsEEDFELEQDEDVLDTWFSSGLFPFSTLGWPDQTddLQRFFPTSLLETGSDILFFWVA 554
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  565 RMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSKSIGNIVAPQQVVQGASLESLKAGLEQsceaGIITPSELKASTIGMT 644
Cdd:PTZ00419 555 RMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLNQKLYE----GNLPEKEIKRAIELQK 630
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  645 QMFPNGIQECGTDALRFTLMSHNIKSHFISFDVNACHTNKLFLNKVWQAMRFTLGSAKGL--GISLHQFETLEGVNLGLW 722
Cdd:PTZ00419 631 KEFPNGIPECGTDALRFGLLAYTQQGRNINLDINRVVGYRHFCNKLWNAVKFALMKLLKDfnLPNSTLFKPNNVESLPWE 710
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  723 DRWIVGRLAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETTKPAIG--NRSADAYIHVGTLTACLSWGLQAMAP 800
Cdd:PTZ00419 711 DKWILHRLNVAIKEVTEGFKEYDFSEATQATYNFWLYELCDVYLELIKPRLSkqSDGERKQHAQDVLHTVLDIGLRLLHP 790
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  801 YAPFVASELLQHVPLNIELKLS-----------DYKDEKLEEEVNEIVNICHNVRQVKSRNEISKRHHPQLSLFAQNTDS 869
Cdd:PTZ00419 791 MMPFITEELYQRLPNYLRKSESisiakypqpnpGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAKDAEL 870
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  870 EGVLRRHLPQIKVLSRCEDVELELFDESSKISKQLSYFSTAGALCSFGLKLSDGLDLTPE------KRDEMQKAnakklk 943
Cdd:PTZ00419 871 IELIESAENLISTLAKIGSVSVIPPIEEEAEVPKGCGFDVVDNKVIIYLNLDEFIDLKKElaklekKLAKLQKS------ 944
                        970       980       990      1000
                 ....*....|....*....|....*....|....*....|....*.
gi 21355675  944 klvteLQRYRMRLDNEAFQLMADKKVKSHFENKVKELEAEINSLTR 989
Cdd:PTZ00419 945 -----LESYLKKISIPNYEDKVPEDVRKLNDEKIDELNEEIKQLEQ 985
ValS COG0525
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ...
39-987 0e+00

Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440291 [Multi-domain]  Cd Length: 877  Bit Score: 820.83  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  39 LAAGYQPQPVEN---AYWErehrQANLPKASASScKRGTYRMLLPPPNVTGNLHLGHALMATVQDVIARQREQLGYQVDW 115
Cdd:COG0525   3 LPKTYDPKEVEAkwyQYWE----ENGYFKADPDS-DKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLW 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 116 VPGTDHAGIATQVVVERTIAAsQAKTRHELGRSAFLDEVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNV 195
Cdd:COG0525  78 QPGTDHAGIATQAVVERQLAE-EGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVRE 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 196 AFERLFEEGLIQRRNSVVNWCTALRSAISDIEVDSVEITepveisvpgydhkvlfGRMYDFAYHVVDGEalpdgsvEEIV 275
Cdd:COG0525 157 VFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVK----------------GHLWHIRYPLADGS-------GYIV 213
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 276 VSTTRPETILGDVAVAVHPLDPRYAKYrnIDQvKLKHPFRDDTIPLVFDITVDQEFGTGAVKITPAHDKFDFELATRHKL 355
Cdd:COG0525 214 VATTRPETMLGDTAVAVHPEDERYKHL--IGK-TVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNL 290
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 356 EPRQVFTETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKDVIEYMILPQWFLKCKDLAKDA 435
Cdd:COG0525 291 PMINILDEDGTINENAGKYRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPA 370
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 436 LSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAYevIDSQGNsqWVAALDEKTARQKAmrliGSEEftL 515
Cdd:COG0525 371 IEAVEDGEIKFVPERWEKTYFHWMENIRDWCISRQLWWGHRIPAW--YCPDGE--VYVARTEPEACAKA----GSVN--L 440
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 516 KRDPDVLDTWFSSSLLPFSTAGWPEES--YKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHG 593
Cdd:COG0525 441 TQDEDVLDTWFSSALWPFSTLGWPEKTedLKYFYPTSVLVTGFDIIFFWVARMIMMGLHFTGEVPFKDVYIHGLVRDEQG 520
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 594 RKMSKSIGNIVAPqqvvqgasleslkagleqsceagiitpselkastIGMtqmfpngIQECGTDALRFTLMSHNIKSHFI 673
Cdd:COG0525 521 RKMSKSKGNVIDP----------------------------------LDL-------IDKYGADALRFTLAALASPGRDI 559
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 674 SFDVNACHTNKLFLNKVWQAMRFTLGSAKGLGISLhqfeTLEGVNLGLWDRWIVGRLAETLSVCSQSYSNYNFHLATAAL 753
Cdd:COG0525 560 KFDEERVEGYRNFANKLWNASRFVLMNLEGFDPGL----DPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQAL 635
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 754 KTFFYQYLCDTYLETTKPAIGNRSADAYIHV-GTLTACLSWGLQAMAPYAPFVASELLQHVPLNIE---LKLSDY----- 824
Cdd:COG0525 636 YDFVWNEFCDWYLELAKPRLYGGDEAAKRETrATLVYVLEQILRLLHPFMPFITEEIWQKLPPRKEgesIMLAPWpeade 715
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 825 --KDEKLEEEVNEIVNICHNVRQVKSRNEISKRHHPQLSLFAQNTDSEGVLRRHLPQIKVLSRCEDVElelFDESSKISK 902
Cdd:COG0525 716 elIDEEAEAEFEWLKEVISAIRNIRAEMNIPPSKKLPLLLKGADEADRARLEENAAYIKRLARLEEIT---ILVDEKPEG 792
                       890       900       910       920       930       940       950       960
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 903 QLSYFSTAGALCsfgLKLSDGLDLTPEK------RDEMQKanakklkklvtELQRYRMRLDNEAFQLMADKKV------- 969
Cdd:COG0525 793 AASAVVGGAEVF---LPLEGLIDVEAERarlekeLAKLEK-----------EIARVEKKLSNEGFVAKAPAEVvekerek 858
                       970
                ....*....|....*...
gi 21355675 970 KSHFENKVKELEAEINSL 987
Cdd:COG0525 859 LAEAEAKLEKLEEQLARL 876
valS TIGR00422
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ...
43-891 0e+00

valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273070 [Multi-domain]  Cd Length: 861  Bit Score: 702.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675    43 YQPQPVENAYWER-EHRQANLPKASASSCKrgtYRMLLPPPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDH 121
Cdd:TIGR00422   5 YDPHEVEKKWYKKwEKSGFFKPDGNSNKPP---FCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDH 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   122 AGIATQVVVERTIAAsQAKTRHELGRSAFLDEVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLF 201
Cdd:TIGR00422  82 AGIATQVKVEKKLGA-EGKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   202 EEGLIQRRNSVVNWCTALRSAISDIEVdsveITEPVEISVPGYDHKvlfgrmydfayhvvdgeaLPDGSVEEIVVSTTRP 281
Cdd:TIGR00422 161 EKGLIYRGEYLVNWDPKLNTAISDIEV----EYKEVKGKLYYIRYP------------------LANGSKDYLVVATTRP 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   282 ETILGDVAVAVHPLDPRYAKYrnIDQvKLKHPFRDDTIPLVFDITVDQEFGTGAVKITPAHDKFDFELATRHKLEPRQVF 361
Cdd:TIGR00422 219 ETMFGDTAVAVHPEDERYKHL--IGK-KVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINIL 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   362 TETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKDVIEYMILPQWFLKCKDLAKDALSELHS 441
Cdd:TIGR00422 296 DEDGLLNENAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAEE 375
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   442 GRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAYeVIDSQGNSqWVAALDEKTARQKAMrligSEEFTLKRDPDV 521
Cdd:TIGR00422 376 GEIKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVW-YCKECGEV-YVAKEEPLPDDKTNT----GPSVELEQDTDV 449
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   522 LDTWFSSSLLPFSTAGWPEES--YKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSKS 599
Cdd:TIGR00422 450 LDTWFSSSLWPFSTLGWPDETkdLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKS 529
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   600 IGNIVAPQQVvqgasleslkagleqsceagiitpselkastigmtqmfpngIQECGTDALRFTLMSHNIKSHFISFDVNA 679
Cdd:TIGR00422 530 LGNVIDPLDV-----------------------------------------IEKYGADALRFTLASLVTPGDDINFDWKR 568
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   680 CHTNKLFLNKVWQAMRFTLgsakglgISLHQFETLEG--VNLGLWDRWIVGRLAETLSVCSQSYSNYNFHLATAALKTFF 757
Cdd:TIGR00422 569 VESARNFLNKLWNASRFVL-------MNLSDDLELSGgeEKLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFI 641
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   758 YQYLCDTYLETTKPAIGNRSAD---AYIHvgTLTACLSWGLQAMAPYAPFVASELLQHVP---LNIELK-----LSDYKD 826
Cdd:TIGR00422 642 WNDFCDWYIELVKYRLYNGNEAekkAARD--TLYYVLDKALRLLHPFMPFITEEIWQHFKegaDSIMLQsypvvDAEFVD 719
                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21355675   827 EKLEEEVNEIVNICHNVRQVKSRNEISKRHHPQLSLFAQNTDSEGVLRRHLPQIKVLSRCEDVEL 891
Cdd:TIGR00422 720 EEAEKAFELLKEIIVSIRNLKAESNIPPNAPLKVLLIYTEAETAERLKLNAVDIKGAINFSEVEV 784
tRNA-synt_1 pfam00133
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ...
71-665 0e+00

tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.


Pssm-ID: 459685 [Multi-domain]  Cd Length: 602  Bit Score: 546.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675    71 KRGTYRMLLPPPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQAKTRHELGRSAF 150
Cdd:pfam00133  21 GKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVVEKKLGIKEKKTRHKYGREEF 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   151 LDEVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTALRSAISDIEVDS 230
Cdd:pfam00133 101 REKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGKKLVNWSPALNTALSNLEVEY 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   231 VEITEPveisvpgydhkvlfgrMYDFAYHVVDGEALpdgsveEIVVSTTRPETILGDVAVAVHPlDPRYA---------- 300
Cdd:pfam00133 181 KDVKGP----------------SIHVAFPLADDEGA------SLVIWTTTPWTLPGNTAVAVNP-EFDYVitgegyilae 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   301 -------------------KYRNIDQVKLKHPFRDDTIPLVFDITVDQEFGTGAVKITPAHDKFDFELATRHKLEPRQVF 361
Cdd:pfam00133 238 allkslykkgtdkkiledfRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPV 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   362 TETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKDVIEYMILPQWFLKCKDLAKDALSELHs 441
Cdd:pfam00133 318 DDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWFVRMDELADQALEAVE- 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   442 gRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAY------EVIDSQGNSQWVAALDEKTARQK-----AMRLIGS 510
Cdd:pfam00133 397 -KVQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWvskdteEVVCRGELFELVAGRFEEEGSIKwlhreAKDKLGY 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   511 EEFTLKRDPDVLDTWFSSSLLPFSTAGWPEES---YKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGI 587
Cdd:pfam00133 476 GKGTLEQDEDVLDTWFSSGSWPFSTLGWPFVNteeFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTGSVPFKNVLVHGL 555
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21355675   588 VCDAHGRKMSKSIGNIVAPQQVvqgasleslkagleqsceagiitpselkastigmtqmfpngIQECGTDALRFTLMS 665
Cdd:pfam00133 556 VRDEQGRKMSKSLGNVIDPLDV-----------------------------------------IDKYGADALRLWLAN 592
ValRS_core cd00817
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ...
73-675 5.00e-178

catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 185677 [Multi-domain]  Cd Length: 382  Bit Score: 522.19  E-value: 5.00e-178
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  73 GTYRMLLPPPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQaKTRHELGRSAFLD 152
Cdd:cd00817   1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEG-KTRHDLGREEFLE 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 153 EVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTALRSAISDIEVdsve 232
Cdd:cd00817  80 KCWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV---- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 233 itepveisvpgydhkvlfgrmydfayhvvdgealpdgsveeivvsttrpetilgdvavavhpldpryakyrnidqvklkh 312
Cdd:cd00817     --------------------------------------------------------------------------------
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 313 pfrddtiplvfditvdqefgtgavkitpahdkfdfelatrhkleprqvftetglvvdayseykgiprfeardlivnrlee 392
Cdd:cd00817     --------------------------------------------------------------------------------
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 393 mdllrqvrshtmqlpiCSRSKDVIEYMILPQWFLKCKDLAKDALSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLW 472
Cdd:cd00817 156 ----------------CSRSGDVIEPLLKPQWFVKVKDLAKKALEAVKEGDIKFVPERMEKRYENWLENIRDWCISRQLW 219
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 473 WGHQVPAYEVIDsqgNSQWVAALDEKTARQKA--MRLIGSEEFTLKRDPDVLDTWFSSSLLPFSTAGWPEES--YKERYP 548
Cdd:cd00817 220 WGHRIPAWYCKD---GGHWVVAREEDEAIDKAapEACVPCGGEELKQDEDVLDTWFSSSLWPFSTLGWPEETkdLKKFYP 296
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 549 LDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSKSIGNIVAPQQVvqgasleslkagleqscea 628
Cdd:cd00817 297 TSLLVTGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDV------------------- 357
                       570       580       590       600
                ....*....|....*....|....*....|....*....|....*..
gi 21355675 629 giitpselkastigmtqmfpngIQECGTDALRFTLMSHNIKSHFISF 675
Cdd:cd00817 358 ----------------------IDGYGADALRFTLASAATQGRDINL 382
 
Name Accession Description Interval E-value
PTZ00419 PTZ00419
valyl-tRNA synthetase-like protein; Provisional
23-989 0e+00

valyl-tRNA synthetase-like protein; Provisional


Pssm-ID: 240411 [Multi-domain]  Cd Length: 995  Bit Score: 966.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   23 YSLYYSTLKDA-ANELPLAAGYQPQPVEN---AYWERE--HRQANLPKASASSCKrgtYRMLLPPPNVTGNLHLGHALMA 96
Cdd:PTZ00419   7 IKLSKDEKKNKkRNISSMAASYDPKEVESgwyEWWEKSgfFKPAEDAKSLNSGKK---FVIVLPPPNVTGYLHIGHALTG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   97 TVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQAKTRHELGRSAFLDEVWRWKAEKGAGIVQDLRQLGCKL 176
Cdd:PTZ00419  84 AIQDSLIRYHRMKGDETLWVPGTDHAGIATQVVVEKKLMKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  177 NWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTALRSAISDIEVDSVEITEPVEISVPGYDHKVLFGRMYDF 256
Cdd:PTZ00419 164 DWSREVFTMDEQRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEKPTKITIPGYDKKVEVGVLWHF 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  257 AYHVVDGEAlpdgsvEEIVVSTTRPETILGDVAVAVHPLDPRYAKYRNidqVKLKHPF-RDDTIPLVFD-ITVDQEFGTG 334
Cdd:PTZ00419 244 AYPLEDSGQ------EEIVVATTRIETMLGDVAVAVHPKDERYKKLHG---KELIHPFiPDRKIPIIADdELVDMEFGTG 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  335 AVKITPAHDKFDFELATRHKLEPRQVFTETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKD 414
Cdd:PTZ00419 315 AVKITPAHDPNDYEIAKRHNLPFINIFTLDGKINENGGEFAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGD 394
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  415 VIEYMILPQWFLKCKDLAKDALSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAYEVI------DSQGN 488
Cdd:PTZ00419 395 IVEPMLIPQWYVNCKDMAKRAVEAVRNGELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYRVIskgpetDPSDE 474
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  489 SQWVAALDEKTARQKAMRLIG--SEEFTLKRDPDVLDTWFSSSLLPFSTAGWPEES--YKERYPLDIMQTGHDIIFFWVA 564
Cdd:PTZ00419 475 EPWVVARSEEEALEKAKKKFGlsEEDFELEQDEDVLDTWFSSGLFPFSTLGWPDQTddLQRFFPTSLLETGSDILFFWVA 554
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  565 RMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSKSIGNIVAPQQVVQGASLESLKAGLEQsceaGIITPSELKASTIGMT 644
Cdd:PTZ00419 555 RMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLNQKLYE----GNLPEKEIKRAIELQK 630
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  645 QMFPNGIQECGTDALRFTLMSHNIKSHFISFDVNACHTNKLFLNKVWQAMRFTLGSAKGL--GISLHQFETLEGVNLGLW 722
Cdd:PTZ00419 631 KEFPNGIPECGTDALRFGLLAYTQQGRNINLDINRVVGYRHFCNKLWNAVKFALMKLLKDfnLPNSTLFKPNNVESLPWE 710
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  723 DRWIVGRLAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETTKPAIG--NRSADAYIHVGTLTACLSWGLQAMAP 800
Cdd:PTZ00419 711 DKWILHRLNVAIKEVTEGFKEYDFSEATQATYNFWLYELCDVYLELIKPRLSkqSDGERKQHAQDVLHTVLDIGLRLLHP 790
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  801 YAPFVASELLQHVPLNIELKLS-----------DYKDEKLEEEVNEIVNICHNVRQVKSRNEISKRHHPQLSLFAQNTDS 869
Cdd:PTZ00419 791 MMPFITEELYQRLPNYLRKSESisiakypqpnpGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAKDAEL 870
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  870 EGVLRRHLPQIKVLSRCEDVELELFDESSKISKQLSYFSTAGALCSFGLKLSDGLDLTPE------KRDEMQKAnakklk 943
Cdd:PTZ00419 871 IELIESAENLISTLAKIGSVSVIPPIEEEAEVPKGCGFDVVDNKVIIYLNLDEFIDLKKElaklekKLAKLQKS------ 944
                        970       980       990      1000
                 ....*....|....*....|....*....|....*....|....*.
gi 21355675  944 klvteLQRYRMRLDNEAFQLMADKKVKSHFENKVKELEAEINSLTR 989
Cdd:PTZ00419 945 -----LESYLKKISIPNYEDKVPEDVRKLNDEKIDELNEEIKQLEQ 985
ValS COG0525
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ...
39-987 0e+00

Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440291 [Multi-domain]  Cd Length: 877  Bit Score: 820.83  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  39 LAAGYQPQPVEN---AYWErehrQANLPKASASScKRGTYRMLLPPPNVTGNLHLGHALMATVQDVIARQREQLGYQVDW 115
Cdd:COG0525   3 LPKTYDPKEVEAkwyQYWE----ENGYFKADPDS-DKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLW 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 116 VPGTDHAGIATQVVVERTIAAsQAKTRHELGRSAFLDEVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNV 195
Cdd:COG0525  78 QPGTDHAGIATQAVVERQLAE-EGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVRE 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 196 AFERLFEEGLIQRRNSVVNWCTALRSAISDIEVDSVEITepveisvpgydhkvlfGRMYDFAYHVVDGEalpdgsvEEIV 275
Cdd:COG0525 157 VFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVK----------------GHLWHIRYPLADGS-------GYIV 213
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 276 VSTTRPETILGDVAVAVHPLDPRYAKYrnIDQvKLKHPFRDDTIPLVFDITVDQEFGTGAVKITPAHDKFDFELATRHKL 355
Cdd:COG0525 214 VATTRPETMLGDTAVAVHPEDERYKHL--IGK-TVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNL 290
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 356 EPRQVFTETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKDVIEYMILPQWFLKCKDLAKDA 435
Cdd:COG0525 291 PMINILDEDGTINENAGKYRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPA 370
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 436 LSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAYevIDSQGNsqWVAALDEKTARQKAmrliGSEEftL 515
Cdd:COG0525 371 IEAVEDGEIKFVPERWEKTYFHWMENIRDWCISRQLWWGHRIPAW--YCPDGE--VYVARTEPEACAKA----GSVN--L 440
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 516 KRDPDVLDTWFSSSLLPFSTAGWPEES--YKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHG 593
Cdd:COG0525 441 TQDEDVLDTWFSSALWPFSTLGWPEKTedLKYFYPTSVLVTGFDIIFFWVARMIMMGLHFTGEVPFKDVYIHGLVRDEQG 520
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 594 RKMSKSIGNIVAPqqvvqgasleslkagleqsceagiitpselkastIGMtqmfpngIQECGTDALRFTLMSHNIKSHFI 673
Cdd:COG0525 521 RKMSKSKGNVIDP----------------------------------LDL-------IDKYGADALRFTLAALASPGRDI 559
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 674 SFDVNACHTNKLFLNKVWQAMRFTLGSAKGLGISLhqfeTLEGVNLGLWDRWIVGRLAETLSVCSQSYSNYNFHLATAAL 753
Cdd:COG0525 560 KFDEERVEGYRNFANKLWNASRFVLMNLEGFDPGL----DPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQAL 635
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 754 KTFFYQYLCDTYLETTKPAIGNRSADAYIHV-GTLTACLSWGLQAMAPYAPFVASELLQHVPLNIE---LKLSDY----- 824
Cdd:COG0525 636 YDFVWNEFCDWYLELAKPRLYGGDEAAKRETrATLVYVLEQILRLLHPFMPFITEEIWQKLPPRKEgesIMLAPWpeade 715
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 825 --KDEKLEEEVNEIVNICHNVRQVKSRNEISKRHHPQLSLFAQNTDSEGVLRRHLPQIKVLSRCEDVElelFDESSKISK 902
Cdd:COG0525 716 elIDEEAEAEFEWLKEVISAIRNIRAEMNIPPSKKLPLLLKGADEADRARLEENAAYIKRLARLEEIT---ILVDEKPEG 792
                       890       900       910       920       930       940       950       960
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 903 QLSYFSTAGALCsfgLKLSDGLDLTPEK------RDEMQKanakklkklvtELQRYRMRLDNEAFQLMADKKV------- 969
Cdd:COG0525 793 AASAVVGGAEVF---LPLEGLIDVEAERarlekeLAKLEK-----------EIARVEKKLSNEGFVAKAPAEVvekerek 858
                       970
                ....*....|....*...
gi 21355675 970 KSHFENKVKELEAEINSL 987
Cdd:COG0525 859 LAEAEAKLEKLEEQLARL 876
valS PRK05729
valyl-tRNA synthetase; Reviewed
39-994 0e+00

valyl-tRNA synthetase; Reviewed


Pssm-ID: 235582 [Multi-domain]  Cd Length: 874  Bit Score: 800.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   39 LAAGYQPQPVE---NAYWErehrQANLPKASASSCKrgTYRMLLPPPNVTGNLHLGHALMATVQDVIARQREQLGYQVDW 115
Cdd:PRK05729   5 LPKTYDPKEVEakwYQKWE----EKGYFKPDDNSKK--PFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLW 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  116 VPGTDHAGIATQVVVERTIAAsQAKTRHELGRSAFLDEVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNV 195
Cdd:PRK05729  79 LPGTDHAGIATQMVVERQLAA-EGKSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVRE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  196 AFERLFEEGLIQRRNSVVNWCTALRSAISDIEVDSVEitepVEisvpgydhkvlfGRMYDFAYHVVDGEalpdgsvEEIV 275
Cdd:PRK05729 158 VFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKE----VK------------GKLWHIRYPLADGS-------DYLV 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  276 VSTTRPETILGDVAVAVHPLDPRYAKYrnIDQvKLKHPFRDDTIPLVFDITVDQEFGTGAVKITPAHDKFDFELATRHKL 355
Cdd:PRK05729 215 VATTRPETMLGDTAVAVNPEDERYKHL--IGK-TVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNL 291
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  356 EPRQVFTETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKDVIEYMILPQWFLKCKDLAKDA 435
Cdd:PRK05729 292 PMINIMDEDGTINENPGEYQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPA 371
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  436 LSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAYevIDSQGNsQWVAAlDEKTARQKAmrligseefTL 515
Cdd:PRK05729 372 LEAVENGEIKFVPERWEKTYFHWMENIQDWCISRQLWWGHRIPAW--YDEDGE-VYVGR-EEPEAREKA---------LL 438
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  516 KRDPDVLDTWFSSSLLPFSTAGWPEES--YKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHG 593
Cdd:PRK05729 439 TQDEDVLDTWFSSALWPFSTLGWPEKTedLKRFYPTSVLVTGFDIIFFWVARMIMMGLHFTGQVPFKDVYIHGLVRDEQG 518
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  594 RKMSKSIGNivapqqvvqgasleslkagleqsceagIITPSELkastigmtqmfpngIQECGTDALRFTLMSHNIKSHFI 673
Cdd:PRK05729 519 RKMSKSKGN---------------------------VIDPLDL--------------IDKYGADALRFTLAALASPGRDI 557
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  674 SFDVNACHTNKLFLNKVWQAMRFTLGSAKGlgislHQFETLEGVN-LGLWDRWIVGRLAETLSVCSQSYSNYNFHLATAA 752
Cdd:PRK05729 558 RFDEERVEGYRNFANKLWNASRFVLMNLEG-----ADVGELPDPEeLSLADRWILSRLNRTVAEVTEALDKYRFDEAARA 632
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  753 LKTFFYQYLCDTYLETTKPAIGNRSADAYIHvgTLTACLSWGLQAMAPYAPFVASELLQHVP---LNIELKLSDY----- 824
Cdd:PRK05729 633 LYEFIWNEFCDWYLELAKPVLQEAAKRATRA--TLAYVLEQILRLLHPFMPFITEELWQKLAplgIEESIMLAPWpeade 710
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  825 -KDEKLEEEVNEIVNICHNVRQVKSRNEISKRHHPQLSLFAQNTDSEGVLRRHLPQIKVLSRCEdvELELFDESSKISKQ 903
Cdd:PRK05729 711 aIDEAAEAEFEWLKELITAIRNIRAEMNIPPSKKLPLLLKGADAEDRARLEANEAYIKRLARLE--SLEILADDEEAPEG 788
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  904 LSYFSTAGAlcSFGLKLSDGLDLTPEK---RDEMQKANAkklkklvtELQRYRMRLDNEAFQLMADKKVKSHFENKVKEL 980
Cdd:PRK05729 789 AASAVVGGA--ELFLPLEGLIDVEAELarlEKELAKLEK--------EIERVEKKLSNEGFVAKAPEEVVEKEREKLAEY 858
                        970
                 ....*....|....*
gi 21355675  981 EAEINSLT-RLAVLS 994
Cdd:PRK05729 859 EEKLAKLKeRLARLK 873
PLN02381 PLN02381
valyl-tRNA synthetase
39-891 0e+00

valyl-tRNA synthetase


Pssm-ID: 215214 [Multi-domain]  Cd Length: 1066  Bit Score: 742.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675    39 LAAGYQPQPVEN---AYWERehrqANLPKASASSCKRgTYRMLLPPPNVTGNLHLGHALMATVQDVIARQREQLGYQVDW 115
Cdd:PLN02381   96 MAKQYSPSAVEKswyAWWEK----SGYFGADAKSSKP-PFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALW 170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   116 VPGTDHAGIATQVVVERTIAASQAKTRHELGRSAFLDEVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNV 195
Cdd:PLN02381  171 VPGVDHAGIATQVVVEKKLMRERHLTRHDIGREEFVSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKAVTE 250
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   196 AFERLFEEGLIQRRNSVVNWCTALRSAISDIEVDSVEITEPVEISVPGYDHKVLFGRMYDFAYHVvdgealpDGSVEEIV 275
Cdd:PLN02381  251 AFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEVDYIDIKERTLLKVPGYDKPVEFGVLTSFAYPL-------EGGLGEIV 323
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   276 VSTTRPETILGDVAVAVHPLDPRYA----KYRNidqvklkHPFRDDTIPLVFD-ITVDQEFGTGAVKITPAHDKFDFELA 350
Cdd:PLN02381  324 VATTRIETMLGDTAIAIHPDDERYKhlhgKFAV-------HPFNGRKLPIICDaILVDPNFGTGAVKITPAHDPNDFEVG 396
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   351 TRHKLEPRQVFTETGLVVD-AYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKDVIEYMILPQWFLKCK 429
Cdd:PLN02381  397 KRHNLEFINIFTDDGKINSnGGSEFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWFVNCS 476
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   430 DLAKDALSELHSG---RLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAYEVI--DSQ------GNSQWVAALDEK 498
Cdd:PLN02381  477 SMAKQALDAAIDGenkKLEFIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWYVTleDDQlkelgsYNDHWVVARNES 556
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   499 TARQKAMRLIGSEEFTLKRDPDVLDTWFSSSLLPFSTAGWPEES--YKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGE 576
Cdd:PLN02381  557 DALLEASQKFPGKKFELSQDPDVLDTWFSSGLFPLSVLGWPDDTddLKAFYPTSVLETGHDILFFWVARMVMMGMQLGGD 636
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   577 APFQRILLNGIVCDAHGRKMSKSIGNIVAPQQVVQGASLEslkaGLEQSCEAGIITPSELKASTIGMTQMFPNGIQECGT 656
Cdd:PLN02381  637 VPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINGISLE----GLHKRLEEGNLDPKELVVAKEGQKKDFPNGIAECGT 712
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   657 DALRFTLMSHNIKSHFISFDVNACHTNKLFLNKVWQAMRFTLGSakgLGISLHQFETLEGVNLGLWDRWIVGRLAETLSV 736
Cdd:PLN02381  713 DALRFALVSYTAQSDKINLDILRVVGYRQWCNKLWNAVRFAMSK---LGDDYTPPATLSVETMPFSCKWILSVLNKAISK 789
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   737 CSQSYSNYNFHLATAALKTFFYQYLCDTYLETTKPAIGNRS---ADAYIHV-GTLTACLSWGLQAMAPYAPFVASELLQH 812
Cdd:PLN02381  790 TVSSLDAYEFSDAASTVYSWWQYQFCDVFIEAIKPYFAGDNpefASERAAAqDTLWICLDTGLRLLHPFMPFVTEELWQR 869
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   813 VP------LNIELKLSDY-------KDEKLEEEVNEIVNICHNVRQVKSRnEISKRHHPQLSLFA--QNTDSEGVLRRHL 877
Cdd:PLN02381  870 LPqpkdhtRKDSIMISEYpsaveawTNEKVEYEMDLVLSTVKCLRSLRAE-VLEKQKNERLPAFAlcRNQEIAAIIKSHQ 948
                         890
                  ....*....|....
gi 21355675   878 PQIKVLSRCEDVEL 891
Cdd:PLN02381  949 LEILTLANLSSLKV 962
valS TIGR00422
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ...
43-891 0e+00

valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273070 [Multi-domain]  Cd Length: 861  Bit Score: 702.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675    43 YQPQPVENAYWER-EHRQANLPKASASSCKrgtYRMLLPPPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDH 121
Cdd:TIGR00422   5 YDPHEVEKKWYKKwEKSGFFKPDGNSNKPP---FCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDH 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   122 AGIATQVVVERTIAAsQAKTRHELGRSAFLDEVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLF 201
Cdd:TIGR00422  82 AGIATQVKVEKKLGA-EGKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   202 EEGLIQRRNSVVNWCTALRSAISDIEVdsveITEPVEISVPGYDHKvlfgrmydfayhvvdgeaLPDGSVEEIVVSTTRP 281
Cdd:TIGR00422 161 EKGLIYRGEYLVNWDPKLNTAISDIEV----EYKEVKGKLYYIRYP------------------LANGSKDYLVVATTRP 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   282 ETILGDVAVAVHPLDPRYAKYrnIDQvKLKHPFRDDTIPLVFDITVDQEFGTGAVKITPAHDKFDFELATRHKLEPRQVF 361
Cdd:TIGR00422 219 ETMFGDTAVAVHPEDERYKHL--IGK-KVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINIL 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   362 TETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKDVIEYMILPQWFLKCKDLAKDALSELHS 441
Cdd:TIGR00422 296 DEDGLLNENAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAEE 375
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   442 GRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAYeVIDSQGNSqWVAALDEKTARQKAMrligSEEFTLKRDPDV 521
Cdd:TIGR00422 376 GEIKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVW-YCKECGEV-YVAKEEPLPDDKTNT----GPSVELEQDTDV 449
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   522 LDTWFSSSLLPFSTAGWPEES--YKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSKS 599
Cdd:TIGR00422 450 LDTWFSSSLWPFSTLGWPDETkdLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKS 529
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   600 IGNIVAPQQVvqgasleslkagleqsceagiitpselkastigmtqmfpngIQECGTDALRFTLMSHNIKSHFISFDVNA 679
Cdd:TIGR00422 530 LGNVIDPLDV-----------------------------------------IEKYGADALRFTLASLVTPGDDINFDWKR 568
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   680 CHTNKLFLNKVWQAMRFTLgsakglgISLHQFETLEG--VNLGLWDRWIVGRLAETLSVCSQSYSNYNFHLATAALKTFF 757
Cdd:TIGR00422 569 VESARNFLNKLWNASRFVL-------MNLSDDLELSGgeEKLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFI 641
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   758 YQYLCDTYLETTKPAIGNRSAD---AYIHvgTLTACLSWGLQAMAPYAPFVASELLQHVP---LNIELK-----LSDYKD 826
Cdd:TIGR00422 642 WNDFCDWYIELVKYRLYNGNEAekkAARD--TLYYVLDKALRLLHPFMPFITEEIWQHFKegaDSIMLQsypvvDAEFVD 719
                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21355675   827 EKLEEEVNEIVNICHNVRQVKSRNEISKRHHPQLSLFAQNTDSEGVLRRHLPQIKVLSRCEDVEL 891
Cdd:TIGR00422 720 EEAEKAFELLKEIIVSIRNLKAESNIPPNAPLKVLLIYTEAETAERLKLNAVDIKGAINFSEVEV 784
valS PRK14900
valyl-tRNA synthetase; Provisional
35-853 0e+00

valyl-tRNA synthetase; Provisional


Pssm-ID: 237855 [Multi-domain]  Cd Length: 1052  Bit Score: 637.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675    35 NELPLAAGYQPQPVEnAYWEREHRQANLPKASASSCKRGTYRMLLPPPNVTGNLHLGHALMATVQDVIARQREQLGYQVD 114
Cdd:PRK14900   11 NRTELAKGYEHREVE-ARWYPFWQERGYFHGDEHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTL 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   115 WVPGTDHAGIATQVVVERTIAASQAKTRHELGRSAFLDEVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVN 194
Cdd:PRK14900   90 WLPGTDHAGIATQMIVEKELKKTEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVR 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   195 VAFERLFEEGLIQRRNSVVNWCTALRSAISDIEVDSVEITEpveisvpgydhkvlfGRMYDFAYHVVDGEAlpdgsveEI 274
Cdd:PRK14900  170 EVFVRLHEEGLIYREKKLINWCPDCRTALSDLEVEHEEAHQ---------------GELWSFAYPLADGSG-------EI 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   275 VVSTTRPETILGDVAVAVHPLDPRyakYRNIDQVKLKHPFRDDTIPLVFD-ITVDQEFGTGAVKITPAHDKFDFELATRH 353
Cdd:PRK14900  228 VVATTRPETMLGDTAVAVHPLDPR---YMALHGKKVRHPITGRTFPIVADaILVDPKFGTGAVKVTPAHDFNDFEVGKRH 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   354 KLEPRQVFTETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKDVIEYMILPQWFLKCKDLAK 433
Cdd:PRK14900  305 GLEMITVIGPDGRMTAEAGPLAGLDRFEARKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEPLAR 384
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   434 DALSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAYEVIDSQgnsqwvaaldEKTARQK--AMRLIGSE 511
Cdd:PRK14900  385 PAIEAVEQGRTRFIPEQWTNTYMAWMRNIHDWCISRQLWWGHQIPAWYCPDGH----------VTVARETpeACSTCGKA 454
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   512 EFtlKRDPDVLDTWFSSSLLPFSTAGWPEESYKER--YPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVC 589
Cdd:PRK14900  455 EL--RQDEDVLDTWFSSGLWPFSTMGWPEQTDTLRtfYPTSVMETGHDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMVR 532
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   590 DAHGRKMSKSIGNIVAPQQVvqgasleslkagleqsceagiitpselkastigmtqmfpngIQECGTDALRFTLMSHNIK 669
Cdd:PRK14900  533 DEKGQKMSKTKGNVIDPLVI-----------------------------------------TEQYGADALRFTLAALTAQ 571
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   670 SHFISFDVNACHTNKLFLNKVWQAMRFTLgsaKGLGISLHQFETLEGVNLGLWDRWIVGRLAETLSVCSQSYSNYNFHLA 749
Cdd:PRK14900  572 GRDIKLAKERIEGYRAFANKLWNASRFAL---MNLSGYQERGEDPARLARTPADRWILARLQRAVNETVEALEAFRFNDA 648
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   750 TAALKTFFYQYLCDTYLETTKPAIGNRSADAYIHV-GTLTACLSWGLQAMAPYAPFVASELLQHVPLNI----------- 817
Cdd:PRK14900  649 ANAVYAFVWHELCDWYIELAKEALASEDPEARRSVqAVLVHCLQTSYRLLHPFMPFITEELWHVLRAQVgasawadsvla 728
                         810       820       830
                  ....*....|....*....|....*....|....*..
gi 21355675   818 -ELKLSDYKDEKLEEEVNEIVNICHNVRQVKSRNEIS 853
Cdd:PRK14900  729 aEYPRKGEADEAAEAAFRPVLGIIDAVRNIRGEMGIP 765
tRNA-synt_1 pfam00133
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ...
71-665 0e+00

tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.


Pssm-ID: 459685 [Multi-domain]  Cd Length: 602  Bit Score: 546.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675    71 KRGTYRMLLPPPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQAKTRHELGRSAF 150
Cdd:pfam00133  21 GKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVVEKKLGIKEKKTRHKYGREEF 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   151 LDEVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTALRSAISDIEVDS 230
Cdd:pfam00133 101 REKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGKKLVNWSPALNTALSNLEVEY 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   231 VEITEPveisvpgydhkvlfgrMYDFAYHVVDGEALpdgsveEIVVSTTRPETILGDVAVAVHPlDPRYA---------- 300
Cdd:pfam00133 181 KDVKGP----------------SIHVAFPLADDEGA------SLVIWTTTPWTLPGNTAVAVNP-EFDYVitgegyilae 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   301 -------------------KYRNIDQVKLKHPFRDDTIPLVFDITVDQEFGTGAVKITPAHDKFDFELATRHKLEPRQVF 361
Cdd:pfam00133 238 allkslykkgtdkkiledfRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPV 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   362 TETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKDVIEYMILPQWFLKCKDLAKDALSELHs 441
Cdd:pfam00133 318 DDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWFVRMDELADQALEAVE- 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   442 gRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAY------EVIDSQGNSQWVAALDEKTARQK-----AMRLIGS 510
Cdd:pfam00133 397 -KVQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWvskdteEVVCRGELFELVAGRFEEEGSIKwlhreAKDKLGY 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   511 EEFTLKRDPDVLDTWFSSSLLPFSTAGWPEES---YKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGI 587
Cdd:pfam00133 476 GKGTLEQDEDVLDTWFSSGSWPFSTLGWPFVNteeFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTGSVPFKNVLVHGL 555
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21355675   588 VCDAHGRKMSKSIGNIVAPQQVvqgasleslkagleqsceagiitpselkastigmtqmfpngIQECGTDALRFTLMS 665
Cdd:pfam00133 556 VRDEQGRKMSKSLGNVIDPLDV-----------------------------------------IDKYGADALRLWLAN 592
ValRS_core cd00817
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ...
73-675 5.00e-178

catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 185677 [Multi-domain]  Cd Length: 382  Bit Score: 522.19  E-value: 5.00e-178
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  73 GTYRMLLPPPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQaKTRHELGRSAFLD 152
Cdd:cd00817   1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEG-KTRHDLGREEFLE 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 153 EVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTALRSAISDIEVdsve 232
Cdd:cd00817  80 KCWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV---- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 233 itepveisvpgydhkvlfgrmydfayhvvdgealpdgsveeivvsttrpetilgdvavavhpldpryakyrnidqvklkh 312
Cdd:cd00817     --------------------------------------------------------------------------------
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 313 pfrddtiplvfditvdqefgtgavkitpahdkfdfelatrhkleprqvftetglvvdayseykgiprfeardlivnrlee 392
Cdd:cd00817     --------------------------------------------------------------------------------
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 393 mdllrqvrshtmqlpiCSRSKDVIEYMILPQWFLKCKDLAKDALSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLW 472
Cdd:cd00817 156 ----------------CSRSGDVIEPLLKPQWFVKVKDLAKKALEAVKEGDIKFVPERMEKRYENWLENIRDWCISRQLW 219
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 473 WGHQVPAYEVIDsqgNSQWVAALDEKTARQKA--MRLIGSEEFTLKRDPDVLDTWFSSSLLPFSTAGWPEES--YKERYP 548
Cdd:cd00817 220 WGHRIPAWYCKD---GGHWVVAREEDEAIDKAapEACVPCGGEELKQDEDVLDTWFSSSLWPFSTLGWPEETkdLKKFYP 296
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 549 LDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSKSIGNIVAPQQVvqgasleslkagleqscea 628
Cdd:cd00817 297 TSLLVTGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDV------------------- 357
                       570       580       590       600
                ....*....|....*....|....*....|....*....|....*..
gi 21355675 629 giitpselkastigmtqmfpngIQECGTDALRFTLMSHNIKSHFISF 675
Cdd:cd00817 358 ----------------------IDGYGADALRFTLASAATQGRDINL 382
PLN02943 PLN02943
aminoacyl-tRNA ligase
79-993 9.28e-176

aminoacyl-tRNA ligase


Pssm-ID: 215509 [Multi-domain]  Cd Length: 958  Bit Score: 537.22  E-value: 9.28e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   79 LPPPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQAKtRHELGRSAFLDEVWRWK 158
Cdd:PLN02943  94 MPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQLVVEKMLASEGIK-RTDLGRDEFTKRVWEWK 172
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  159 AEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTALRSAISDIEVDSVEitEPve 238
Cdd:PLN02943 173 EKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGSYMVNWSPNLQTAVSDLEVEYSE--EP-- 248
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  239 isvpgydhkvlfGRMYDFAYHVVDGealpdgSVEEIVVSTTRPETILGDVAVAVHPLDPRYAKYrnIDQVKLKHPFRDDT 318
Cdd:PLN02943 249 ------------GTLYYIKYRVAGG------SEDFLTIATTRPETLFGDVAIAVNPEDDRYSKY--IGKMAIVPMTYGRH 308
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  319 IPLVFDITVDQEFGTGAVKITPAHDKFDFELATRHKLEPRQVFTETGLVvdaySEYKGIPRFEARDLIVNRLEEMDLLRQ 398
Cdd:PLN02943 309 VPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTL----NEVAGLYWFEAREKLWSDLEETGLAVK 384
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  399 VRSHTMQLPICSRSKDVIEYMILPQWFLKCKDLAKDALSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVP 478
Cdd:PLN02943 385 KEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKALKAVENGELTIIPERFEKIYNHWLSNIKDWCISRQLWWGHRIP 464
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  479 AYEVIDSQGNSQWVAALDEKTARQKAMRLIGsEEFTLKRDPDVLDTWFSSSLLPFSTAGWPE---ESYKERYPLDIMQTG 555
Cdd:PLN02943 465 VWYIVGKDCEEDYIVARSAEEALEKAREKYG-KDVEIYQDPDVLDTWFSSALWPFSTLGWPDvsaEDFKKFYPTTVLETG 543
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  556 HDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSKSIGNIVAPQqvvqgasleslkagleqsceagiitpse 635
Cdd:PLN02943 544 HDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPL---------------------------- 595
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  636 lkastigmtqmfpNGIQECGTDALRFTLmSHNIKSHFISFDVNACHTNKLFLNKVWQAMRFTLGSAKGLG-------ISL 708
Cdd:PLN02943 596 -------------DTIKEFGTDALRFTL-ALGTAGQDLNLSTERLTSNKAFTNKLWNAGKFVLQNLPSQSdtsawehILA 661
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  709 HQFETLEGV-NLGLWDRWIVGRLAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETTKPAI---GNRSADAYIHv 784
Cdd:PLN02943 662 CKFDKEESLlSLPLPECWVVSKLHELIDSVTTSYDKYFFGDVGREIYDFFWSDFADWYIEASKTRLyhsGDNSALSRAQ- 740
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  785 GTLTACLSWGLQAMAPYAPFVASELLQHVPLNIE-LKLSDYKDEKLEEEVNEIV---NICHNVRQVK-SRNEISKRHHPQ 859
Cdd:PLN02943 741 AVLLYVFENILKLLHPFMPFVTEELWQALPYRKEaLIVSPWPQTSLPKDLKSIKrfeNLQSLTRAIRnARAEYSVEPAKR 820
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  860 LSLF-AQNTDSEGVLRRHLPQIKVLSRCeDVELELFDESSKISKQLSYFSTAGALCSFGLKLSDGLDLTPE-----KR-D 932
Cdd:PLN02943 821 ISASiVASAEVIEYISKEKEVLALLSRL-DLQNVHFTDSPPGDANQSVHLVASEGLEAYLPLADMVDISAEverlsKRlS 899
                        890       900       910       920       930       940
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21355675  933 EMQkanakklkklvTELQRYRMRLDNEAFQLMADKKVKSHFENKVKELEAEIN-SLTRLAVL 993
Cdd:PLN02943 900 KMQ-----------TEYDALAARLSSPKFVEKAPEDVVRGVREKAAEAEEKIKlTKNRLAFL 950
valS PRK13208
valyl-tRNA synthetase; Reviewed
80-853 3.98e-118

valyl-tRNA synthetase; Reviewed


Pssm-ID: 237306 [Multi-domain]  Cd Length: 800  Bit Score: 381.08  E-value: 3.98e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   80 PPPNVTGNLHLGHALMATVQDVIARQREQLGYQVdWVP-GTDHAGIATQVVVERT--IaasqakTRHELGRSAFLDEVWR 156
Cdd:PRK13208  45 PPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNV-FFPqGWDDNGLPTERKVEKYygI------RKDDISREEFIELCRE 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  157 WKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTALRSAISDIEVDSVEITep 236
Cdd:PRK13208 118 LTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYRERE-- 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  237 veisvpgydhkvlfGRMYDFAYHVVDGealpdgsvEEIVVSTTRPETILGDVAVAVHPLDPRYAKYRNidqvklKH---P 313
Cdd:PRK13208 196 --------------GKLNYIKFPVEDG--------EEIEIATTRPELLPACVAVVVHPDDERYKHLVG------KTaivP 247
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  314 FRDDTIPLVFDITVDQEFGTGAVKITPAHDKFDFELATRHKLEPRQVFTETGLVVDAYSEYKGIPRFEARDLIVNRLEEM 393
Cdd:PRK13208 248 LFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIIIDEDGRMTEAAGKLAGLTIEEARKKIVEDLKSG 327
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  394 DLLRQVRSHTMQLPICSRSKDVIEYMILPQWFLKCKDLaKDALSELhSGRLQILPPNFETEWERWLQD-SRDWCISRQ-- 470
Cdd:PRK13208 328 GLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDL-KEELLER-GKEINWYPEHMRVRLENWIEGlNWDWCISRQry 405
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  471 ------LWW----GHQVPAYE---VID--SQgnsqwVAALDEKTARqkamrliGSEEFTlkRDPDVLDTWFSSSLLPFST 535
Cdd:PRK13208 406 fgtpipVWYckdcGHPILPDEedlPVDptKD-----EPPGYKCPQC-------GSPGFE--GETDVMDTWATSSITPLIV 471
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  536 AGWPEES--YKERYPLDIMQTGHDIIFFW----VARMMMlglkLTGEAPFQRILLNGIVCDAHGRKMSKSIGNivapqqv 609
Cdd:PRK13208 472 TGWERDEdlFEKVFPMDLRPQGHDIIRTWlfytILRAYL----LTGKLPWKNIMISGMVLDPDGKKMSKSKGN------- 540
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  610 vqgasleslkagleqsceagIITPSELkastigmtqmfpngIQECGTDALRFTLMSHNIKSHFiSFDVNACHTNKLFLNK 689
Cdd:PRK13208 541 --------------------VVTPEEL--------------LEKYGADAVRYWAASARLGSDT-PFDEKQVKIGRRLLTK 585
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  690 VWQAMRFTLGSAKGLGISLHqfETLEGVnlglwDRWIVGRLAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETT 769
Cdd:PRK13208 586 LWNASRFVLHFSADPEPDKA--EVLEPL-----DRWILAKLAKVVEKATEALENYDFAKALEEIESFFWHVFCDDYLELV 658
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  770 K-------PAIGNRSADAYIHVgTLTAClswgLQAMAPYAPFVASELLQHVP------LNIELKLSDYKDEKLEEEVNEI 836
Cdd:PRK13208 659 KsraygedEEEEQKSARYTLYT-VLDTL----LRLLAPFLPFITEEVWSWLYggsvhrASWPEPDEELIDEEDEELGELA 733
                        810
                 ....*....|....*..
gi 21355675  837 VNICHNVRQVKSRNEIS 853
Cdd:PRK13208 734 KEILSAVRKYKSEAGLS 750
IleS COG0060
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ...
81-851 9.19e-67

Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439830 [Multi-domain]  Cd Length: 931  Bit Score: 241.91  E-value: 9.19e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  81 PPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTD-HaGIATQVVVERT--IAASQAKtrhELGRSAFLDE---- 153
Cdd:COG0060  54 PPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGWDcH-GLPIELKVEKElgIKKKDIE---KVGIAEFREKcrey 129
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 154 VWRWKAE-KgagivQDLRQLGCKLNWQREYFTMD----EQQAHAvnvaFERLFEEGLIQRRNSVVNWCTALRSAISDIEV 228
Cdd:COG0060 130 ALKYVDEqR-----EDFKRLGVWGDWDNPYLTMDpeyeESIWWA----LKKLYEKGLLYKGLKPVPWCPRCGTALAEAEV 200
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 229 DSVEITEPveiSVpgydhkvlfgrmyDFAYHVVDGEALPDGSVEEIVVSTTRPETILGDVAVAVHP-LDprYAKYRNIDQ 307
Cdd:COG0060 201 EYKDVTSP---SI-------------YVKFPVKDEKALLLLEDAYLVIWTTTPWTLPANLAVAVHPdID--YVLVEVTGG 262
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 308 -----------------------------------VKLKHPFR-----DDTIPLVFD--ITVDQefGTGAVKITPAH--D 343
Cdd:COG0060 263 erlilaealveavlkelgiedyevlatfkgaelegLRYEHPFYyvvgyDRAHPVILGdyVTTED--GTGIVHTAPGHgeD 340
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 344 kfDFELATRHKLEPRQVFTETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKD-VIeYMILP 422
Cdd:COG0060 341 --DFEVGKKYGLPVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALLAREKITHSYPHCWRCKTpLI-YRATP 417
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 423 QWFLKCKDLAKDALSElhsgrlqilppNFETEW------ER---WLQDSRDWCISRQLWWG------------HQVPAYE 481
Cdd:COG0060 418 QWFISMDKLRDRALEA-----------IEKVNWipewgeGRfgnMLENRPDWCISRQRYWGvpipiwvcedcgELHRTEE 486
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 482 VIDS-------QGNSQWVAA------LDEKTARQKamrliGSEEFTlkRDPDVLDTWFSSSLLPFSTAgwpEESYKERYP 548
Cdd:COG0060 487 VIGSvaelleeEGADAWFELdlhrpfLDETLKCPK-----CGGTMR--RVPDVLDVWFDSGSMHFAVL---ENREELHFP 556
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 549 LD-IM----QTghdiiffwvaR-----MMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSKSIGNIVAPQQVvqgaslesl 618
Cdd:COG0060 557 ADfYLegsdQT----------RgwfysSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEV--------- 617
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 619 kagleqsceagiitpselkastigmtqmfpngIQECGTDALRFTLMSHNiKSHFISFDVNACHTNKLFLNKVWQAMRFTL 698
Cdd:COG0060 618 --------------------------------IDKYGADILRLWVASSD-YWGDLRFSDEILKEVRDVYRRLRNTYRFLL 664
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 699 GsakglgiSLHQF----ETLEGVNLGLWDRWIVGRLAETLSVCSQSYSNYNFHLATAALKTF-------FY-------QY 760
Cdd:COG0060 665 A-------NLDDFdpaeDAVPYEDLPELDRWILSRLNELIKEVTEAYDNYDFHRAYRALHNFcvedlsnWYldiskdrLY 737
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 761 lcdtyleTTKP-AIGNRSA-DAYIHVgtLTACLSWglqaMAPYAPFVASELLQHVPLNIELK--LSDY-------KDEKL 829
Cdd:COG0060 738 -------TEAAdSLDRRAAqTTLYEV--LETLVRL----LAPILPFTAEEIWQNLPGEAEESvhLADWpevdeelIDEEL 804
                       890       900
                ....*....|....*....|....
gi 21355675 830 EEEVNEIVNICHNVRQV--KSRNE 851
Cdd:COG0060 805 EAKWDLVREVRSAVLKAleAARKE 828
Ile_Leu_Val_MetRS_core cd00668
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ...
80-611 2.51e-43

catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.


Pssm-ID: 185674 [Multi-domain]  Cd Length: 312  Bit Score: 160.28  E-value: 2.51e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  80 PPPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERtIAASQAKTRHelgRSAFLDEVWRWKA 159
Cdd:cd00668   7 PPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAER-KGGRKKKTIW---IEEFREDPKEFVE 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 160 EKGAGIVQDLRQLGCKLNWQREYFTMDEqqahavnvaferlfeegliqRRNSVVNWctalrsaisdievdsveitepvei 239
Cdd:cd00668  83 EMSGEHKEDFRRLGISYDWSDEYITTEP--------------------EYSKAVEL------------------------ 118
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 240 svpgydhkvLFGRMYdfayhvvdgealpdgsveeivvsttrpetilgdvavavhpldpryakyrnidqvklkhpfrddti 319
Cdd:cd00668 119 ---------IFSRLY----------------------------------------------------------------- 124
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 320 plvfditvdqefgtgavkitpahdkfdfelatrhkleprqvftETGLVVDAYseykgiprfeardlivnrleemdllRQV 399
Cdd:cd00668 125 -------------------------------------------EKGLIYRGT-------------------------HPV 136
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 400 RSHtmqlpicsrskdvieymilPQWFLKCKDLAKDALSELHSGRlqILPPNFETEWERWLQDSRDWCISRQLWWGHQVPa 479
Cdd:cd00668 137 RIT-------------------EQWFFDMPKFKEKLLKALRRGK--IVPEHVKNRMEAWLESLLDWAISRQRYWGTPLP- 194
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 480 yevidsqgnsqwvaaldektarqkamrligseeftlkrdPDVLDTWFSSSLLPFSTAGWPEES--YKERYPLDIMQTGHD 557
Cdd:cd00668 195 ---------------------------------------EDVFDVWFDSGIGPLGSLGYPEEKewFKDSYPADWHLIGKD 235
                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....
gi 21355675 558 IIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSKSIGNIVAPQQVVQ 611
Cdd:cd00668 236 ILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVE 289
PLN02843 PLN02843
isoleucyl-tRNA synthetase
81-814 5.73e-41

isoleucyl-tRNA synthetase


Pssm-ID: 215452 [Multi-domain]  Cd Length: 974  Bit Score: 163.40  E-value: 5.73e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   81 PPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIaasQAKTRHELGRSAFldevwRWKAE 160
Cdd:PLN02843  40 PPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIELKVLQSL---DQEARKELTPIKL-----RAKAA 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  161 KGAGIVQD-----LRQLGCKLNWQREYFTMD-EQQAHAVNVaFERLFEEGLIQRRNSVVNWCTALRSAISDIEVDSVEit 234
Cdd:PLN02843 112 KFAKKTVDtqresFKRYGVWGDWENPYLTLDpEYEAAQIEV-FGQMFLNGYIYRGRKPVHWSPSSRTALAEAELEYPE-- 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  235 epveisvpGYDHKVLFgrmydFAYHVVDG---------EALPDGSVeeiVVSTTRPETILGDVAVAVHP-LD-------- 296
Cdd:PLN02843 189 --------GHVSKSIY-----VAFPVVSPsetspeeleEFLPGLSL---AIWTTTPWTMPANAAVAVNDkLQysvvevqs 252
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  297 ------------PRYAKYRNIDQVKL------------------------------------KHPFRDDTIPLVFD---I 325
Cdd:PLN02843 253 fsedestsggnkKKRPGNVLKEQQKLflivatdlvpaleakwgvklvvlktfpgsdlegcryIHPLYNRESPVVIGgdyI 332
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  326 TVdqEFGTGAVKITPAHDKFDFELATRHKLEPRQVFTETGLVVDAYSEYKGIPRF-EARDLIVNRLEEMDLLRQVRSHTM 404
Cdd:PLN02843 333 TT--ESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQFSGLSVLgEGNAAVVEALDEAGSLLMEEAYGH 410
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  405 QLPICSRSKDVIEYMILPQWFLKCKDLAKDALSELhsGRLQILPPNFETEWeRWLQDSR-DWCISRQLWWGHQVPAY--- 480
Cdd:PLN02843 411 KYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAI--DKVKWIPAQGENRI-RAMVSGRsDWCISRQRTWGVPIPVFyhv 487
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  481 ----------------EVIDSQGNSQW----VAALDEKTARQKAMRLigseeftlKRDPDVLDTWFSSSllpFSTAGWPE 540
Cdd:PLN02843 488 etkeplmneetiahvkSIVAQKGSDAWwymdVEDLLPEKYRDKASDY--------EKGTDTMDVWFDSG---SSWAGVLG 556
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  541 ESYKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSKSIGNIVAPQQVVQGasleslka 620
Cdd:PLN02843 557 SREGLSYPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEG-------- 628
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  621 GLEQSCEAGIitpselkastigmtqmfpngiqecGTDALRFTLMSHNIKShfisfDVnACHTNKL-----FLNKVWQAMR 695
Cdd:PLN02843 629 GKNQKQEPAY------------------------GADVLRLWVASVDYTG-----DV-LIGPQILkqmsdIYRKLRGTLR 678
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  696 FTLGsakglgiSLHQFETLEGV---NLGLWDRWIVGRLAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETTKPA 772
Cdd:PLN02843 679 YLLG-------NLHDWKPDNAVpyeDLPSIDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKDR 751
                        810       820       830       840
                 ....*....|....*....|....*....|....*....|....*
gi 21355675  773 IGNRSADAYIHVG---TLTACLSWGLQAMAPYAPFVASELLQHVP 814
Cdd:PLN02843 752 LYVGGTTSFTRRScqtVLAAHLLSLLRAIAPILPHLAEDAWQNLP 796
Anticodon_Ia_Val cd07962
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ...
675-812 1.10e-34

Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.


Pssm-ID: 153416 [Multi-domain]  Cd Length: 135  Bit Score: 128.83  E-value: 1.10e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 675 FDVNACHTNKLFLNKVWQAMRFTLGSAKGLGISLHQFETLEgvnlgLWDRWIVGRLAETLSVCSQSYSNYNFHLATAALK 754
Cdd:cd07962   1 FDEKRVEGGRNFCNKLWNAARFVLMNLEDDDEPEEDPESLS-----LADRWILSRLNKTVEEVTEALENYRFSEAATALY 75
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21355675 755 TFFYQYLCDTYLETTKPAIGNRSADA-YIHVGTLTACLSWGLQAMAPYAPFVASELLQH 812
Cdd:cd07962  76 EFFWNDFCDWYLELVKPRLYGEDEEEkKAARATLYYVLETILRLLHPFMPFITEELWQR 134
IleRS_core cd00818
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ...
348-610 8.89e-34

catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173909 [Multi-domain]  Cd Length: 338  Bit Score: 133.13  E-value: 8.89e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 348 ELATRHKLEPRQVFTETGLVVDAYSEYKGI-PRFEARDL-IVNRLEEMDLL-RQVRShtMQLPICSRSkdvieymiLPQW 424
Cdd:cd00818  84 EFALRYVDEQEEQFQRLGVWVDWENPYKTMdPEYMESVWwVFKQLHEKGLLyRGYKV--VPWPLIYRA--------TPQW 153
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 425 FL---KCKDLAKDALSELHsgrlqILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAyevidsqgnsqWVAALDEktar 501
Cdd:cd00818 154 FIrvtKIKDRLLEANDKVN-----WIPEWVKNRFGNWLENRRDWCISRQRYWGTPIPV-----------WYCEDCG---- 213
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 502 qkamrligseEFTLKRDPDVLDTWFSSSLLPFSTAGWPEES--YKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPF 579
Cdd:cd00818 214 ----------EVLVRRVPDVLDVWFDSGSMPYAQLHYPFENedFEELFPADFILEGSDQTRGWFYSLLLLSTALFGKAPY 283
                       250       260       270
                ....*....|....*....|....*....|.
gi 21355675 580 QRILLNGIVCDAHGRKMSKSIGNIVAPQQVV 610
Cdd:cd00818 284 KNVIVHGFVLDEDGRKMSKSLGNYVDPQEVV 314
PLN02882 PLN02882
aminoacyl-tRNA ligase
81-888 7.60e-33

aminoacyl-tRNA ligase


Pssm-ID: 215477 [Multi-domain]  Cd Length: 1159  Bit Score: 137.93  E-value: 7.60e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675    81 PPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIAtqvvVERTIAASQAKTRHE----LGRSAFLDE--- 153
Cdd:PLN02882   46 PPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGLP----VEYEIDKKLGIKRRDdvlkMGIDKYNEEcrs 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   154 -VWRWKAEKGAGIVQdlrqLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTALRSAISDIEV--DS 230
Cdd:PLN02882  122 iVTRYSKEWEKTVTR----TGRWIDFENDYKTMDPKFMESVWWVFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEAglNY 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   231 VEITEP-VEISVPgydhkvlfgrmydfayhVVDGealPDGSveEIVVSTTRPETILGDVAVAVHPlDPRYAKYRN----- 304
Cdd:PLN02882  198 KDVSDPaVMVSFP-----------------IVGD---PDNA--SFVAWTTTPWTLPSNLALCVNP-NFTYVKVRNkytgk 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   305 ----------------------------------------IDQVKLKHP--------FRDDTIPLVFDITVDQEFGTGAV 336
Cdd:PLN02882  255 vyivaesrlsalptakpkskkgskpenaaegyevlakvpgSSLVGKKYEplfdyfseFSDTAFRVVADDYVTDDSGTGVV 334
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   337 KITPAHDKFDFELATRHKL------EPRQVfTETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICS 410
Cdd:PLN02882  335 HCAPAFGEDDYRVCLANGIiekggnLPVPV-DDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKGRLVKSGSITHSYPFCW 413
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   411 RSKDVIEYMILPQWFLKCKDLaKDalselhsgrlQILPPNFETEW----------ERWLQDSRDWCISRQLWWGHQVPAY 480
Cdd:PLN02882  414 RSDTPLIYRAVPSWFVKVEEI-KD----------RLLENNKQTYWvpdyvkekrfHNWLENARDWAVSRSRFWGTPLPIW 482
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   481 E--------VIDSqgnsqwVAALdEKTARQKAMRL---------IGSE---EFT-LKRDPDVLDTWFSSSLLPFSTAGWP 539
Cdd:PLN02882  483 IsddgeevvVIGS------IAEL-EKLSGVKVTDLhrhfidhitIPSSrgpEFGvLRRVDDVFDCWFESGSMPYAYIHYP 555
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   540 ---EESYKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSKSIGNIVAPQQVvqgasle 616
Cdd:PLN02882  556 fenKELFEKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEV------- 628
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   617 slkagleqsceagiitpselkastigmtqmfpngIQECGTDALRFTLM-SHNIKSHFISFDVNACHT--NKLFLnKVWQA 693
Cdd:PLN02882  629 ----------------------------------IDKYGADALRLYLInSPVVRAEPLRFKEEGVFGvvKDVFL-PWYNA 673
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   694 MRFTLGSAKGLGI-SLHQFETLEGVNL----GLWDRWIVGRLAETLSVCSQSYSNYNFHLATAALKTFFYQyLCDTYLET 768
Cdd:PLN02882  674 YRFLVQNAKRLEVeGGAPFVPLDLAKLqnsaNVLDRWINSATQSLVKFVREEMGAYRLYTVVPYLVKFIDN-LTNIYVRF 752
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   769 TKPAIGNRSADAYIHVG-------TLTAClswglQAMAPYAPFVASELLQHVPLNIE--------LKLSDYK----DEKL 829
Cdd:PLN02882  753 NRKRLKGRTGEEDCRTAlstlynvLLTSC-----KVMAPFTPFFTEVLYQNLRKVLPgseesihyCSFPQVDegelDERI 827
                         890       900       910       920       930       940       950
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   830 EEEVNEIVNICHNVRQVKSRNEISKRH--------HPQLSLFAqntDSEGVLRRHLPQ---IKVLSRCED 888
Cdd:PLN02882  828 EQSVSRMQTVIELARNIRERHNKPLKTplkemvvvHPDAEFLD---DITGKLKEYVLEelnVRSLVPCND 894
PTZ00427 PTZ00427
isoleucine-tRNA ligase, putative; Provisional
81-625 3.16e-32

isoleucine-tRNA ligase, putative; Provisional


Pssm-ID: 173617 [Multi-domain]  Cd Length: 1205  Bit Score: 135.86  E-value: 3.16e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675    81 PPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQAKTRHELGRSAFLDEVWRWKAE 160
Cdd:PTZ00427  110 PPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPIEYEIEKENNINKKEDILKMGIDVYNEKCRGIVLK 189
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   161 KGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTALRSAISDIEVD---------SV 231
Cdd:PTZ00427  190 YSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYVYKSFKVMPYSCKCNTPISNFELNlnykdtpdpSI 269
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   232 EIT-------EPVEISVPGYDHKVLFGRMYDFAYHVVDGEALPDGSVE----------EIVVSTTRPETILGDVAVAV-- 292
Cdd:PTZ00427  270 IISfvlcsdfPKVEEECNIEEDKQLLGEKYSVLYNNKRENSNNGNNNStnnvcyaqhsEILAWTTTPWTLPSNLALCVne 349
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   293 --------HPLDPR---YAKYR----------NIDQVKL-----------------------KHPFRDDTIPLVFDITVD 328
Cdd:PTZ00427  350 hftylrihHVKSNRvviVGECRlewimkelkwNVEDLKIvnrfkgkelkglrykplftnfyeKYNFKERAYKILADDFVT 429
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   329 QEFGTGAVKITPAHDKFDFELATRHK-LEPRQ-VFTE----TGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSH 402
Cdd:PTZ00427  430 DDAGTGIVHCAPTYGEDDFRVCKKNGvIDPEKnIFIDpldaNGYFTNEVEEVQNLYIKEADNVIKKKLKNENRLLSNNTI 509
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   403 TMQLPICSRSKDVIEYMILPQWFLKCKDLAKDaLSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAY-- 480
Cdd:PTZ00427  510 VHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNE-LVKNNETTYWIPAHIKEKKFHNWIKDAKDWCISRNRYWGTPIPIWad 588
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   481 EVIDSQGNSQWVAALDEKTARQKAMRL-------------IGSEEFTLKRDPDVLDTWFSSSLLPFSTAGWP----EESY 543
Cdd:PTZ00427  589 EKMETVICVESIKHLEELSGVKNINDLhrhfidhieiknpKGKTYPKLKRIPEVFDCWFESGSMPYAKVHYPfsteKEDF 668
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   544 KERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSKSIGNIVAPQQVVQGASLESLKAGLE 623
Cdd:PTZ00427  669 HKIFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLI 748

                  ..
gi 21355675   624 QS 625
Cdd:PTZ00427  749 NS 750
Anticodon_1 pfam08264
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ...
723-855 1.35e-25

Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.


Pssm-ID: 400523 [Multi-domain]  Cd Length: 141  Bit Score: 103.25  E-value: 1.35e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   723 DRWIVGRLAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETTKPAIGNRSADAYIhVGTLTACLSWGLQAMAPYA 802
Cdd:pfam08264   1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDSRA-QTTLYEVLETLLRLLAPFM 79
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 21355675   803 PFVASELLQH--VPLNIELKLSDYKDEKLEEEVNEIVNICHNVRQVKSRNEISKR 855
Cdd:pfam08264  80 PFITEELWQKesIHLAPWPEDAELEEAELEEAFELRQEIVQAIRKLRSELKIKKS 134
leuS PRK12300
leucyl-tRNA synthetase; Reviewed
88-839 7.95e-21

leucyl-tRNA synthetase; Reviewed


Pssm-ID: 237049 [Multi-domain]  Cd Length: 897  Bit Score: 98.79  E-value: 7.95e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   88 LHLGHALMATVQDVIARQREQLGYQVDW-----VPGTDHAGIAtqvvvERtIAASQAKTRHELgRSAF---LDEVWRWK- 158
Cdd:PRK12300   1 LHVGHGRTYTIGDVIARYKRMRGYNVLFpmafhVTGTPILGIA-----ER-IARGDPETIELY-KSLYgipEEELEKFKd 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  159 --------AEKgagIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTALRSAISD---IE 227
Cdd:PRK12300  74 peyiveyfSEE---AKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDhdlLD 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  228 VDSVEITEPVEISVPGYDHKVLfgrmydfayhvvdgealpdgsveeiVVSTTRPETILGDVAVAVHPlDPRY--AKYRN- 304
Cdd:PRK12300 151 GEEPEIVEYTLIKFEESEDLIL-------------------------PAATLRPETIFGVTNLWVNP-DATYvkAEVDGe 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  305 ---------------------IDQVK--------LKHPFRDDTIPL---VFditVDQEFGTGAVKITPAHDKFDF----- 347
Cdd:PRK12300 205 kwivskeaaeklsfqdrdveiIEEIKgseligkkVKNPVTGKEVPIlpaDF---VDPDNGTGVVMSVPAHAPYDYvalrd 281
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  348 ---ELATRHKLEPRQV------------------------------FTET--------GLVVDAYSEYKGIPRFEARDLI 386
Cdd:PRK12300 282 lkkNKELLDVIEPIPLievegygefpakevveklgiksqedpeleeATKEvyraefhkGVLKENTGEYAGKPVREAREKI 361
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  387 VNRLEEMDLLRqVRSHTMQLPICSR--SKDVIEyMILPQWFLK-----CKDLAKDALSelhsgRLQILPPNFETEWER-- 457
Cdd:PRK12300 362 TKDLIEKGIAD-IMYEFSNRPVYCRcgTECVVK-VVKDQWFIDysdpeWKELAHKALD-----NMEIIPEEYRKEFENti 434
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  458 -WLqdsRDWCISRQLWWGHQVPAYE--VIDSQGNSqwvaaldekT--------ARQKAMRLIGSEEFTlkrdPDVLDTWF 526
Cdd:PRK12300 435 dWL---KDRACARRRGLGTRLPWDEewIIESLSDS---------TiymayytiAHKIREYGIKPEQLT----PEFFDYVF 498
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  527 ---SSSLLPFSTAGWPEESYKE-R------YPLDIMQTGHDII-----FF------------WVARMMMLGLkltgeapf 579
Cdd:PRK12300 499 lgkGDPEEVSKKTGIPKEILEEmReeflywYPVDWRHSGKDLIpnhltFFifnhvaifpeekWPRGIVVNGF-------- 570
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  580 qrILLNgivcdahGRKMSKSIGNIVapqqvvqgaSLEslkagleqscEAgiitpselkastigmtqmfpngIQECGTDAL 659
Cdd:PRK12300 571 --VLLE-------GKKMSKSKGNVI---------PLR----------KA----------------------IEEYGADVV 600
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  660 RFTLMShnikshfisfdvNAchtnklflnKVWQAMRFTLGSAKGLGISLHQFETL--------EGVNLGLWDRWIVGRLA 731
Cdd:PRK12300 601 RLYLTS------------SA---------ELLQDADWREKEVESVRRQLERFYELakelieigGEEELRFIDKWLLSRLN 659
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  732 ETLSVCSQSYSnyNFHLATAALKTFF--YQYLcDTYLETTkPAIGNRSADAYIHVgtltaclsWgLQAMAPYAPFVASEL 809
Cdd:PRK12300 660 RIIKETTEAME--SFQTRDAVQEAFYelLNDL-RWYLRRV-GEANNKVLREVLEI--------W-IRLLAPFTPHLAEEL 726
                        890       900       910       920
                 ....*....|....*....|....*....|....*....|....*..
gi 21355675  810 -----------LQHVPLNIELKLSDYKD------EKLEEEVNEIVNI 839
Cdd:PRK12300 727 whklggegfvsLEKWPEPDESKIDEEAElaeeyvKRLIEDIREILKV 773
PLN02563 PLN02563
aminoacyl-tRNA ligase
51-613 1.55e-19

aminoacyl-tRNA ligase


Pssm-ID: 178177 [Multi-domain]  Cd Length: 963  Bit Score: 94.50  E-value: 1.55e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   51 AYWErEHRQANLPKASASScKRGTYRM-LLPPPNVTGnLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGI-ATQV 128
Cdd:PLN02563  91 RYWE-ENRTFRTPDDVDTS-KPKFYVLdMFPYPSGAG-LHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLpAEQY 167
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  129 VVErTIAASQAKTRHELGRsafldevWRwkaekgagivQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQR 208
Cdd:PLN02563 168 AIE-TGTHPKITTLKNIAR-------FR----------SQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQ 229
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  209 RNSVVNWCTALRSAISDIEV-DSV------------------EITEPVEISVPGYD-----------HKVLFGRMY--DF 256
Cdd:PLN02563 230 AEVPVNWCPALGTVLANEEVvDGLsergghpvirkpmrqwmlKITAYADRLLEDLDdldwpesikemQRNWIGRSEgaEL 309
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  257 AYHVVDGEALPDGsvEEIVVSTTRPETILGDVAVAV---HPLDPRYA---------KYR-------NIDQVKL------- 310
Cdd:PLN02563 310 DFSVLDGEGKERD--EKITVYTTRPDTLFGATYLVVapeHPLLSSLTtaeqkeaveEYVdaasrksDLERTELqkektgv 387
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  311 ------KHPFRDDTIPLVFDITVDQEFGTGAVKITPAHDKFDFELATRHKLEPRQVFT-ETGLVVDAYSEYKGiprfeaR 383
Cdd:PLN02563 388 ftgsyaINPATGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKpADGNEDDAEKAYTG------E 461
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  384 DLIVNRLEEMDLLRQVRSHTmqlpicSRSKdVIEYmilpqwflkckdlakdaLSELHSGRLQIlppNFETewerwlqdsR 463
Cdd:PLN02563 462 GVIVNSSSSGLDINGLSSKE------AAKK-VIEW-----------------LEETGNGKKKV---NYKL---------R 505
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  464 DWCISRQLWWGHQVPAYEVIDSqgnsqwvaalDEKTARQKA---MRLIGSEEFT--------LKRDPDVLDTWFSSSLLP 532
Cdd:PLN02563 506 DWLFARQRYWGEPIPVVFLEDS----------GEPVPVPESdlpLTLPELDDFTptgtgeppLAKAVSWVNTVDPSSGKP 575
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  533 F----ST----AG--W-------PEES------YKERY--PLDIMQTG--HDIIF-----FWVARMMMLGLKLTGEaPFQ 580
Cdd:PLN02563 576 ArretNTmpqwAGscWyylrfmdPKNSnalvdkEKEKYwmPVDLYVGGaeHAVLHllyarFWHKVLYDIGVVSTKE-PFQ 654
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  581 RILLNGIVC---------DAHGR---------------------------------------------KMSKSIGNIVAP 606
Cdd:PLN02563 655 CLVNQGMILgeveytafkDSDGEyvsadtadrlgelqqekipeekviksgdsfvlkddpsirliarahKMSKSRGNVVNP 734

                 ....*....
gi 21355675  607 QQVV--QGA 613
Cdd:PLN02563 735 DDVVseYGA 743
LeuS COG0495
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ...
43-613 1.06e-18

Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440261 [Multi-domain]  Cd Length: 826  Bit Score: 91.65  E-value: 1.06e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  43 YQPQPVEN---AYWErehrQANLPKASASScKRGTYRML--LPPPnvTGNLHLGHALMATVQDVIARQREQLGYQV---- 113
Cdd:COG0495   5 YNPKEIEKkwqKYWE----ENGTFKADEDS-SKPKYYVLdmFPYP--SGRLHMGHVRNYTIGDVVARYKRMQGYNVlhpm 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 114 DWvpgtD-------HAGIATQV----VVERTIAA--SQaktrhelgrsafldevwrwkaekgagivqdLRQLGCKLNWQR 180
Cdd:COG0495  78 GW----DafglpaeNAAIKNGVhpaeWTYENIANmrRQ------------------------------LKRLGLSYDWSR 123
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 181 EYFTMDE-----QQAhavnvAFERLFEEGLIQRRNSVVNWC----TAL--------RSAISDIEVdsveitEPVEIS--- 240
Cdd:COG0495 124 EIATCDPeyykwTQW-----IFLQLYEKGLAYRKEAPVNWCpvdqTVLaneqvidgRCWRCGAPV------EKKELPqwf 192
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 241 ----------------VPGYDHKVL------FGRMY----DFAYhvvdgealpDGSVEEIVVSTTRPETILGD--VAVAV 292
Cdd:COG0495 193 lkitdyadellddldkLDGWPEKVKtmqrnwIGRSEgaevDFPV---------EGSDEKITVFTTRPDTLFGAtfMVLAP 263
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 293 -HPL---------DPRYAKYrnIDQVKLK----------------------HPFRDDTIPlVFdIT--VDQEFGTGAVKI 338
Cdd:COG0495 264 eHPLvkelatpeqNAAVAAF--IEEAKKKseiertsetkektgvftglyaiNPLTGEKIP-IW-IAdyVLMDYGTGAVMA 339
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 339 TPAHDKFDFELATRHKLEPRQV---------------FTETGLVVDAySEYKGIPRFEARDLIVNRLEEMDLlrqvrsht 403
Cdd:COG0495 340 VPAHDQRDFEFAKKYGLPIKQViapedgddpdileeaYTGDGVLINS-GEFDGLDSEEAKEAIIEWLEEKGL-------- 410
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 404 mqlpicsrSKDVIEYmilpqwflkckdlakdalselhsgRLqilppnfetewerwlqdsRDWCISRQLWWG--------- 474
Cdd:COG0495 411 --------GKRKVNY------------------------RL------------------RDWLISRQRYWGepipiihce 440
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 475 ----HQVPAYE---------VIDSQGNS------QWVAALDEKTArQKAmrligseeftlKRDPDVLDTWFSSS------ 529
Cdd:COG0495 441 dcgvVPVPEDQlpvelpedvDFDPTGGSplarapEWVNVTCPKCG-GPA-----------RRETDTMDTFVDSSwyylry 508
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 530 LLP-FSTAGW-PEesyKERY--PLD---------IMqtgHDIIF-FWVARMMMLGLkLTGEAPFQRiLLN-GIVCD---- 590
Cdd:COG0495 509 TDPhNDEAPFdPE---AANYwlPVDqyiggiehaIL---HLLYArFFTKVLRDLGL-VSFDEPFKR-LLTqGMVLEvgkd 580
                       730       740
                ....*....|....*....|....*....
gi 21355675 591 ----AHGRKMSKSIGNIVAPQQVVQ--GA 613
Cdd:COG0495 581 gvviGGIEKMSKSKGNVVDPDEIIEkyGA 609
tRNA-synt_1_2 pfam13603
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ...
268-391 1.79e-13

Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.


Pssm-ID: 433342 [Multi-domain]  Cd Length: 185  Bit Score: 69.88  E-value: 1.79e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   268 DGSVEEIVVSTTRPETILGD--VAVAV-HPL-------DPRYAKY----RNIDQ----------------VKLKHPFRDD 317
Cdd:pfam13603  17 EGTDEKIEVFTTRPDTLMGVtfVALAPeHPLveklaekNPEVAAFieecKNTSEiertsetkekegvftgLYAIHPITGE 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   318 TIPL-----VFDitvdqEFGTGAVKITPAHDKFDFELATRHKLEPRQV----------------FTETGLVVDAySEYKG 376
Cdd:pfam13603  97 KIPIwianfVLM-----EYGTGAVMAVPAHDQRDFEFAKKYNLPIKPViqpedgdldldimteaYTEEGILVNS-GEFDG 170
                         170
                  ....*....|....*
gi 21355675   377 IPRFEARDLIVNRLE 391
Cdd:pfam13603 171 LDSEEAKEAIIKKLE 185
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
419-613 3.74e-12

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 68.43  E-value: 3.74e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 419 MILPQWFLKC-----KDLAKDALSelhsgRLQILPPNFETEWERWLQdsrdwcISRQLWWGHQVPAYEVIDSQGNSQW-- 491
Cdd:cd00812 127 KLLDQWFLKYsetewKEKLLKDLE-----KLDGWPEEVRAMQENWIG------CSRQRYWGTPIPWTDTMESLSDSTWyy 195
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 492 ----VAALDEKTarqkamrligsEEFTLKRDPDVLDTWfsssllpfstagwpeesykerYPLDIMQTGHDII-------- 559
Cdd:cd00812 196 arytDAHNLEQP-----------YEGDLEFDREEFEYW---------------------YPVDIYIGGKEHApnhllysr 243
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21355675 560 FFWVArmmMLGLKLTGEAPFQRILLNGIVCdAHGRKMSKSIGNIVAPQQVVQ--GA 613
Cdd:cd00812 244 FNHKA---LFDEGLVTDEPPKGLIVQGMVL-LEGEKMSKSKGNVVTPDEAIKkyGA 295
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
77-216 1.77e-09

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 60.34  E-value: 1.77e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  77 MLLPPPNvtGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDhagiATQVVVERtiAASQAKTRHElgrsafldevwR 156
Cdd:cd00812   6 VMFPYPS--GALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFD----AFGLPAEN--AAIKIGRDPE-----------D 66
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 157 WKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWC 216
Cdd:cd00812  67 WTEYNIKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC 126
Anticodon_Ia_Ile_BEm cd07960
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ...
694-836 6.12e-07

Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.


Pssm-ID: 153414 [Multi-domain]  Cd Length: 180  Bit Score: 50.60  E-value: 6.12e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 694 MRFTLGSakglgisLHQFETLEGV----NLGLWDRWIVGRLAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETT 769
Cdd:cd07960  20 FRFLLGN-------LNDFDPAKDAvpyeELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCTVDLSAFYLDII 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 770 K-----PAIGN---RSADAYIHVgTLTACLSWglqaMAPYAPFVASELLQHVPLNIELK----------LSDYKDEKLEE 831
Cdd:cd07960  93 KdrlycDAKDSlerRSAQTVLYH-ILDALLKL----LAPILPFTAEEVWEHLPGEKKEEsvfledwpelPEEWKDEELEE 167

                ....*
gi 21355675 832 EVNEI 836
Cdd:cd07960 168 KWEKL 172
tRNA-synt_1g pfam09334
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
407-611 1.09e-06

tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.


Pssm-ID: 401322 [Multi-domain]  Cd Length: 387  Bit Score: 51.91  E-value: 1.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   407 PICSRSKDVIEYMILPQWFLKCKDLAKDALSELHSGRLQiLPPNFETEWERWLQDS-RDWCISRQLWWGHQVPAYE---- 481
Cdd:pfam09334 167 PKCVICGTTPEVKETEHYFFDLSKFQDKLREWIEENNPE-WPENVKNMVLEWLKEGlKDRAISRDLDWGIPVPGAEgkvf 245
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   482 -VidsqgnsqWVAAldektarqkamrLIGSEEFT--LKRDPDVLDTWfsssllpfstagWPEESYKERYPLdimqTGHDI 558
Cdd:pfam09334 246 yV--------WLDA------------PIGYISATkeLSGNEEKWKEW------------WPNDPDTELVHF----IGKDI 289
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 21355675   559 IFF----WVARMMMLGLKLtgeaPfQRILLNGIVcDAHGRKMSKSIGNIVAPQQVVQ 611
Cdd:pfam09334 290 IYFhtifWPAMLLGAGYRL----P-TTVFAHGYL-TYEGGKMSKSRGNVVWPSEALD 340
MetRS_core cd00814
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ...
417-611 1.42e-06

catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.


Pssm-ID: 173907 [Multi-domain]  Cd Length: 319  Bit Score: 51.38  E-value: 1.42e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 417 EYMILPQWFLKCKDLAKDALSELHSGRLQILPPNFETEWERWLQDS-RDWCISRQLW-WGHQVPAYE-----Vidsqgns 489
Cdd:cd00814 133 EWREEEHYFFRLSKFQDRLLEWLEKNPDFIWPENARNEVLSWLKEGlKDLSITRDLFdWGIPVPLDPgkviyV------- 205
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 490 qWVAAldektarqkamrLIGSEEFTLKRDPDVLDTWFSSSllpfstaGWPEESYkerypldIMqtGHDIIFF----WVAR 565
Cdd:cd00814 206 -WFDA------------LIGYISATGYYNEEWGNSWWWKD-------GWPELVH-------FI--GKDIIRFhaiyWPAM 256
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 21355675 566 MMMLGLKLtgeapFQRILLNG-IVCDahGRKMSKSIGNIVAPQQVVQ 611
Cdd:cd00814 257 LLGAGLPL-----PTRIVAHGyLTVE--GKKMSKSRGNVVDPDDLLE 296
PRK11893 PRK11893
methionyl-tRNA synthetase; Reviewed
518-619 2.10e-06

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237012 [Multi-domain]  Cd Length: 511  Bit Score: 51.42  E-value: 2.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  518 DPD-VLDTWFS------SSLLPFSTAGWPEESYKERYPLDIMQTGHDIIFF----WVARMMMLGLKLtgeapFQRILLNG 586
Cdd:PRK11893 217 DPKhVIYVWFDaltnylTALGYPDDEELLAELFNKYWPADVHLIGKDILRFhavyWPAFLMAAGLPL-----PKRVFAHG 291
                         90       100       110
                 ....*....|....*....|....*....|....
gi 21355675  587 -IVCDahGRKMSKSIGNIVAPQQVVQGASLESLK 619
Cdd:PRK11893 292 fLTLD--GEKMSKSLGNVIDPFDLVDEYGVDAVR 323
metG TIGR00398
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ...
80-206 1.02e-05

methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273058 [Multi-domain]  Cd Length: 530  Bit Score: 49.30  E-value: 1.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675    80 PPPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQvvverTIAASQAKTRHELgrsafldeVWRWKA 159
Cdd:TIGR00398   6 ALPYANGKPHLGHAYTTILADVYARYKRLRGYEVLFVCGTDEHGTKIE-----LKAEQEGLTPKEL--------VDKYHE 72
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 21355675   160 EkgagIVQDLRQLGckLNWQREYFTMDEQQAHAVNVAFERLFEEGLI 206
Cdd:TIGR00398  73 E----FKDDWKWLN--ISFDRFIRTTDEEHKEIVQKIFQKLKENGYI 113
PRK12267 PRK12267
methionyl-tRNA synthetase; Reviewed
515-611 1.12e-05

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237028 [Multi-domain]  Cd Length: 648  Bit Score: 49.41  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  515 LKRDPD-VLDTWFSSsLLPFSTA-GWP---EESYKERYPLDIMQTGHDII-F---FWVARMMMLGLKLtgeapFQRILln 585
Cdd:PRK12267 217 VPFDPKhVVYVWIDA-LLNYITAlGYGsddDELFKKFWPADVHLVGKDILrFhaiYWPIMLMALGLPL-----PKKVF-- 288
                         90       100       110
                 ....*....|....*....|....*....|..
gi 21355675  586 givcdAHG------RKMSKSIGNIVAPQQVVQ 611
Cdd:PRK12267 289 -----AHGwwlmkdGKMSKSKGNVVDPEELVD 315
MetRS_core cd00814
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ...
82-206 1.21e-05

catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.


Pssm-ID: 173907 [Multi-domain]  Cd Length: 319  Bit Score: 48.30  E-value: 1.21e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  82 PNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVvertiAASQAKTRHELG--RSAFLDEVWRWka 159
Cdd:cd00814   9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQK-----AEEEGVTPQELCdkYHEIFKDLFKW-- 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 21355675 160 ekgAGIVQDlrqlgcklnwqreYF--TMDEQQAHAVNVAFERLFEEGLI 206
Cdd:cd00814  82 ---LNISFD-------------YFirTTSPRHKEIVQEFFKKLYENGYI 114
PRK11893 PRK11893
methionyl-tRNA synthetase; Reviewed
80-206 1.48e-05

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237012 [Multi-domain]  Cd Length: 511  Bit Score: 48.72  E-value: 1.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   80 PPPNVTGNLHLGHALMATVQDVIAR-QReQLGYQVDWVPGTDHAGiatQVVvertiaasqAKTRHELGRS--AFLDEVwr 156
Cdd:PRK11893   8 PIYYPNGKPHIGHAYTTLAADVLARfKR-LRGYDVFFLTGTDEHG---QKI---------QRKAEEAGISpqELADRN-- 72
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 21355675  157 wkaekGAGIVQDLRQLGCKL-NWQReyfTMDEQQAHAVNVAFERLFEEGLI 206
Cdd:PRK11893  73 -----SAAFKRLWEALNISYdDFIR---TTDPRHKEAVQEIFQRLLANGDI 115
MetG COG0143
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ...
79-206 1.12e-04

Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439913 [Multi-domain]  Cd Length: 544  Bit Score: 45.87  E-value: 1.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675  79 LPPPNvtGNLHLGHAlMATVQ-DVIARQREQLGYQVDWVPGTD-HaGIATQvvvertIAASQAktrhelGRS--AFLDEV 154
Cdd:COG0143   9 IPYAN--GPPHIGHL-YTYIPaDILARYQRLRGHDVLFVTGTDeH-GTKIE------LAAEKE------GITpqELVDRI 72
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 21355675 155 WrwkaekgAGIVQDLRQLGCKL-NWQReyfTMDEQQAHAVNVAFERLFEEGLI 206
Cdd:COG0143  73 H-------AEFKELFEKLGISFdNFIR---TTSPEHKELVQEIFQRLYDNGDI 115
tRNA-synt_1g pfam09334
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
82-218 1.65e-04

tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.


Pssm-ID: 401322 [Multi-domain]  Cd Length: 387  Bit Score: 44.97  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675    82 PNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVvvertiaasQAKtrhELGRSAfldevwrwkAEK 161
Cdd:pfam09334   8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIEL---------KAE---KEGITP---------EEL 66
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 21355675   162 GAGIVQDLRQLGCKLNWQREYF--TMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTA 218
Cdd:pfam09334  67 VDRYHEIHREDFKKFNISFDDYgrTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPS 125
PRK12267 PRK12267
methionyl-tRNA synthetase; Reviewed
84-206 6.70e-04

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237028 [Multi-domain]  Cd Length: 648  Bit Score: 43.64  E-value: 6.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675   84 VTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGiatQVVVErtIAASQAKTRHElgrsaFLDEvwrwkaekga 163
Cdd:PRK12267  15 PNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHG---QKIQQ--AAEKAGKTPQE-----YVDE---------- 74
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 21355675  164 gIVQDLRQLGCKLNWQREYF--TMDEQQAHAVNVAFERLFEEGLI 206
Cdd:PRK12267  75 -ISAGFKELWKKLDISYDKFirTTDERHKKVVQKIFEKLYEQGDI 118
Anticodon_Ia_Leu_AEc cd07959
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ...
715-809 1.84e-03

Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.


Pssm-ID: 153413 [Multi-domain]  Cd Length: 117  Bit Score: 39.11  E-value: 1.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 715 EGVNLGLWDRWIVGRLAETLSVCSQSYSNYNFHlatAALKTFFYQYLCDT--YLETTKPAIGNRSADAYIHVGTLtacls 792
Cdd:cd07959  29 ELEELTFIDRWLLSRLNRLIKETTEAYENMQFR---EALKEGLYELQNDLdwYRERGGAGMNKDLLRRFIEVWTR----- 100
                        90
                ....*....|....*..
gi 21355675 793 wglqAMAPYAPFVASEL 809
Cdd:cd07959 101 ----LLAPFAPHLAEEI 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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