|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
23-989 |
0e+00 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 966.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 23 YSLYYSTLKDA-ANELPLAAGYQPQPVEN---AYWERE--HRQANLPKASASSCKrgtYRMLLPPPNVTGNLHLGHALMA 96
Cdd:PTZ00419 7 IKLSKDEKKNKkRNISSMAASYDPKEVESgwyEWWEKSgfFKPAEDAKSLNSGKK---FVIVLPPPNVTGYLHIGHALTG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 97 TVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQAKTRHELGRSAFLDEVWRWKAEKGAGIVQDLRQLGCKL 176
Cdd:PTZ00419 84 AIQDSLIRYHRMKGDETLWVPGTDHAGIATQVVVEKKLMKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 177 NWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTALRSAISDIEVDSVEITEPVEISVPGYDHKVLFGRMYDF 256
Cdd:PTZ00419 164 DWSREVFTMDEQRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEKPTKITIPGYDKKVEVGVLWHF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 257 AYHVVDGEAlpdgsvEEIVVSTTRPETILGDVAVAVHPLDPRYAKYRNidqVKLKHPF-RDDTIPLVFD-ITVDQEFGTG 334
Cdd:PTZ00419 244 AYPLEDSGQ------EEIVVATTRIETMLGDVAVAVHPKDERYKKLHG---KELIHPFiPDRKIPIIADdELVDMEFGTG 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 335 AVKITPAHDKFDFELATRHKLEPRQVFTETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKD 414
Cdd:PTZ00419 315 AVKITPAHDPNDYEIAKRHNLPFINIFTLDGKINENGGEFAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGD 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 415 VIEYMILPQWFLKCKDLAKDALSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAYEVI------DSQGN 488
Cdd:PTZ00419 395 IVEPMLIPQWYVNCKDMAKRAVEAVRNGELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYRVIskgpetDPSDE 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 489 SQWVAALDEKTARQKAMRLIG--SEEFTLKRDPDVLDTWFSSSLLPFSTAGWPEES--YKERYPLDIMQTGHDIIFFWVA 564
Cdd:PTZ00419 475 EPWVVARSEEEALEKAKKKFGlsEEDFELEQDEDVLDTWFSSGLFPFSTLGWPDQTddLQRFFPTSLLETGSDILFFWVA 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 565 RMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSKSIGNIVAPQQVVQGASLESLKAGLEQsceaGIITPSELKASTIGMT 644
Cdd:PTZ00419 555 RMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLNQKLYE----GNLPEKEIKRAIELQK 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 645 QMFPNGIQECGTDALRFTLMSHNIKSHFISFDVNACHTNKLFLNKVWQAMRFTLGSAKGL--GISLHQFETLEGVNLGLW 722
Cdd:PTZ00419 631 KEFPNGIPECGTDALRFGLLAYTQQGRNINLDINRVVGYRHFCNKLWNAVKFALMKLLKDfnLPNSTLFKPNNVESLPWE 710
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 723 DRWIVGRLAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETTKPAIG--NRSADAYIHVGTLTACLSWGLQAMAP 800
Cdd:PTZ00419 711 DKWILHRLNVAIKEVTEGFKEYDFSEATQATYNFWLYELCDVYLELIKPRLSkqSDGERKQHAQDVLHTVLDIGLRLLHP 790
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 801 YAPFVASELLQHVPLNIELKLS-----------DYKDEKLEEEVNEIVNICHNVRQVKSRNEISKRHHPQLSLFAQNTDS 869
Cdd:PTZ00419 791 MMPFITEELYQRLPNYLRKSESisiakypqpnpGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAKDAEL 870
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 870 EGVLRRHLPQIKVLSRCEDVELELFDESSKISKQLSYFSTAGALCSFGLKLSDGLDLTPE------KRDEMQKAnakklk 943
Cdd:PTZ00419 871 IELIESAENLISTLAKIGSVSVIPPIEEEAEVPKGCGFDVVDNKVIIYLNLDEFIDLKKElaklekKLAKLQKS------ 944
|
970 980 990 1000
....*....|....*....|....*....|....*....|....*.
gi 21355675 944 klvteLQRYRMRLDNEAFQLMADKKVKSHFENKVKELEAEINSLTR 989
Cdd:PTZ00419 945 -----LESYLKKISIPNYEDKVPEDVRKLNDEKIDELNEEIKQLEQ 985
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
39-987 |
0e+00 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 820.83 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 39 LAAGYQPQPVEN---AYWErehrQANLPKASASScKRGTYRMLLPPPNVTGNLHLGHALMATVQDVIARQREQLGYQVDW 115
Cdd:COG0525 3 LPKTYDPKEVEAkwyQYWE----ENGYFKADPDS-DKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLW 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 116 VPGTDHAGIATQVVVERTIAAsQAKTRHELGRSAFLDEVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNV 195
Cdd:COG0525 78 QPGTDHAGIATQAVVERQLAE-EGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVRE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 196 AFERLFEEGLIQRRNSVVNWCTALRSAISDIEVDSVEITepveisvpgydhkvlfGRMYDFAYHVVDGEalpdgsvEEIV 275
Cdd:COG0525 157 VFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVK----------------GHLWHIRYPLADGS-------GYIV 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 276 VSTTRPETILGDVAVAVHPLDPRYAKYrnIDQvKLKHPFRDDTIPLVFDITVDQEFGTGAVKITPAHDKFDFELATRHKL 355
Cdd:COG0525 214 VATTRPETMLGDTAVAVHPEDERYKHL--IGK-TVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 356 EPRQVFTETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKDVIEYMILPQWFLKCKDLAKDA 435
Cdd:COG0525 291 PMINILDEDGTINENAGKYRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPA 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 436 LSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAYevIDSQGNsqWVAALDEKTARQKAmrliGSEEftL 515
Cdd:COG0525 371 IEAVEDGEIKFVPERWEKTYFHWMENIRDWCISRQLWWGHRIPAW--YCPDGE--VYVARTEPEACAKA----GSVN--L 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 516 KRDPDVLDTWFSSSLLPFSTAGWPEES--YKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHG 593
Cdd:COG0525 441 TQDEDVLDTWFSSALWPFSTLGWPEKTedLKYFYPTSVLVTGFDIIFFWVARMIMMGLHFTGEVPFKDVYIHGLVRDEQG 520
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 594 RKMSKSIGNIVAPqqvvqgasleslkagleqsceagiitpselkastIGMtqmfpngIQECGTDALRFTLMSHNIKSHFI 673
Cdd:COG0525 521 RKMSKSKGNVIDP----------------------------------LDL-------IDKYGADALRFTLAALASPGRDI 559
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 674 SFDVNACHTNKLFLNKVWQAMRFTLGSAKGLGISLhqfeTLEGVNLGLWDRWIVGRLAETLSVCSQSYSNYNFHLATAAL 753
Cdd:COG0525 560 KFDEERVEGYRNFANKLWNASRFVLMNLEGFDPGL----DPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQAL 635
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 754 KTFFYQYLCDTYLETTKPAIGNRSADAYIHV-GTLTACLSWGLQAMAPYAPFVASELLQHVPLNIE---LKLSDY----- 824
Cdd:COG0525 636 YDFVWNEFCDWYLELAKPRLYGGDEAAKRETrATLVYVLEQILRLLHPFMPFITEEIWQKLPPRKEgesIMLAPWpeade 715
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 825 --KDEKLEEEVNEIVNICHNVRQVKSRNEISKRHHPQLSLFAQNTDSEGVLRRHLPQIKVLSRCEDVElelFDESSKISK 902
Cdd:COG0525 716 elIDEEAEAEFEWLKEVISAIRNIRAEMNIPPSKKLPLLLKGADEADRARLEENAAYIKRLARLEEIT---ILVDEKPEG 792
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 903 QLSYFSTAGALCsfgLKLSDGLDLTPEK------RDEMQKanakklkklvtELQRYRMRLDNEAFQLMADKKV------- 969
Cdd:COG0525 793 AASAVVGGAEVF---LPLEGLIDVEAERarlekeLAKLEK-----------EIARVEKKLSNEGFVAKAPAEVvekerek 858
|
970
....*....|....*...
gi 21355675 970 KSHFENKVKELEAEINSL 987
Cdd:COG0525 859 LAEAEAKLEKLEEQLARL 876
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
39-994 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 800.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 39 LAAGYQPQPVE---NAYWErehrQANLPKASASSCKrgTYRMLLPPPNVTGNLHLGHALMATVQDVIARQREQLGYQVDW 115
Cdd:PRK05729 5 LPKTYDPKEVEakwYQKWE----EKGYFKPDDNSKK--PFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 116 VPGTDHAGIATQVVVERTIAAsQAKTRHELGRSAFLDEVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNV 195
Cdd:PRK05729 79 LPGTDHAGIATQMVVERQLAA-EGKSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVRE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 196 AFERLFEEGLIQRRNSVVNWCTALRSAISDIEVDSVEitepVEisvpgydhkvlfGRMYDFAYHVVDGEalpdgsvEEIV 275
Cdd:PRK05729 158 VFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKE----VK------------GKLWHIRYPLADGS-------DYLV 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 276 VSTTRPETILGDVAVAVHPLDPRYAKYrnIDQvKLKHPFRDDTIPLVFDITVDQEFGTGAVKITPAHDKFDFELATRHKL 355
Cdd:PRK05729 215 VATTRPETMLGDTAVAVNPEDERYKHL--IGK-TVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 356 EPRQVFTETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKDVIEYMILPQWFLKCKDLAKDA 435
Cdd:PRK05729 292 PMINIMDEDGTINENPGEYQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPA 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 436 LSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAYevIDSQGNsQWVAAlDEKTARQKAmrligseefTL 515
Cdd:PRK05729 372 LEAVENGEIKFVPERWEKTYFHWMENIQDWCISRQLWWGHRIPAW--YDEDGE-VYVGR-EEPEAREKA---------LL 438
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 516 KRDPDVLDTWFSSSLLPFSTAGWPEES--YKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHG 593
Cdd:PRK05729 439 TQDEDVLDTWFSSALWPFSTLGWPEKTedLKRFYPTSVLVTGFDIIFFWVARMIMMGLHFTGQVPFKDVYIHGLVRDEQG 518
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 594 RKMSKSIGNivapqqvvqgasleslkagleqsceagIITPSELkastigmtqmfpngIQECGTDALRFTLMSHNIKSHFI 673
Cdd:PRK05729 519 RKMSKSKGN---------------------------VIDPLDL--------------IDKYGADALRFTLAALASPGRDI 557
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 674 SFDVNACHTNKLFLNKVWQAMRFTLGSAKGlgislHQFETLEGVN-LGLWDRWIVGRLAETLSVCSQSYSNYNFHLATAA 752
Cdd:PRK05729 558 RFDEERVEGYRNFANKLWNASRFVLMNLEG-----ADVGELPDPEeLSLADRWILSRLNRTVAEVTEALDKYRFDEAARA 632
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 753 LKTFFYQYLCDTYLETTKPAIGNRSADAYIHvgTLTACLSWGLQAMAPYAPFVASELLQHVP---LNIELKLSDY----- 824
Cdd:PRK05729 633 LYEFIWNEFCDWYLELAKPVLQEAAKRATRA--TLAYVLEQILRLLHPFMPFITEELWQKLAplgIEESIMLAPWpeade 710
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 825 -KDEKLEEEVNEIVNICHNVRQVKSRNEISKRHHPQLSLFAQNTDSEGVLRRHLPQIKVLSRCEdvELELFDESSKISKQ 903
Cdd:PRK05729 711 aIDEAAEAEFEWLKELITAIRNIRAEMNIPPSKKLPLLLKGADAEDRARLEANEAYIKRLARLE--SLEILADDEEAPEG 788
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 904 LSYFSTAGAlcSFGLKLSDGLDLTPEK---RDEMQKANAkklkklvtELQRYRMRLDNEAFQLMADKKVKSHFENKVKEL 980
Cdd:PRK05729 789 AASAVVGGA--ELFLPLEGLIDVEAELarlEKELAKLEK--------EIERVEKKLSNEGFVAKAPEEVVEKEREKLAEY 858
|
970
....*....|....*
gi 21355675 981 EAEINSLT-RLAVLS 994
Cdd:PRK05729 859 EEKLAKLKeRLARLK 873
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
39-891 |
0e+00 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 742.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 39 LAAGYQPQPVEN---AYWERehrqANLPKASASSCKRgTYRMLLPPPNVTGNLHLGHALMATVQDVIARQREQLGYQVDW 115
Cdd:PLN02381 96 MAKQYSPSAVEKswyAWWEK----SGYFGADAKSSKP-PFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALW 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 116 VPGTDHAGIATQVVVERTIAASQAKTRHELGRSAFLDEVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNV 195
Cdd:PLN02381 171 VPGVDHAGIATQVVVEKKLMRERHLTRHDIGREEFVSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKAVTE 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 196 AFERLFEEGLIQRRNSVVNWCTALRSAISDIEVDSVEITEPVEISVPGYDHKVLFGRMYDFAYHVvdgealpDGSVEEIV 275
Cdd:PLN02381 251 AFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEVDYIDIKERTLLKVPGYDKPVEFGVLTSFAYPL-------EGGLGEIV 323
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 276 VSTTRPETILGDVAVAVHPLDPRYA----KYRNidqvklkHPFRDDTIPLVFD-ITVDQEFGTGAVKITPAHDKFDFELA 350
Cdd:PLN02381 324 VATTRIETMLGDTAIAIHPDDERYKhlhgKFAV-------HPFNGRKLPIICDaILVDPNFGTGAVKITPAHDPNDFEVG 396
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 351 TRHKLEPRQVFTETGLVVD-AYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKDVIEYMILPQWFLKCK 429
Cdd:PLN02381 397 KRHNLEFINIFTDDGKINSnGGSEFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWFVNCS 476
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 430 DLAKDALSELHSG---RLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAYEVI--DSQ------GNSQWVAALDEK 498
Cdd:PLN02381 477 SMAKQALDAAIDGenkKLEFIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWYVTleDDQlkelgsYNDHWVVARNES 556
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 499 TARQKAMRLIGSEEFTLKRDPDVLDTWFSSSLLPFSTAGWPEES--YKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGE 576
Cdd:PLN02381 557 DALLEASQKFPGKKFELSQDPDVLDTWFSSGLFPLSVLGWPDDTddLKAFYPTSVLETGHDILFFWVARMVMMGMQLGGD 636
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 577 APFQRILLNGIVCDAHGRKMSKSIGNIVAPQQVVQGASLEslkaGLEQSCEAGIITPSELKASTIGMTQMFPNGIQECGT 656
Cdd:PLN02381 637 VPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINGISLE----GLHKRLEEGNLDPKELVVAKEGQKKDFPNGIAECGT 712
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 657 DALRFTLMSHNIKSHFISFDVNACHTNKLFLNKVWQAMRFTLGSakgLGISLHQFETLEGVNLGLWDRWIVGRLAETLSV 736
Cdd:PLN02381 713 DALRFALVSYTAQSDKINLDILRVVGYRQWCNKLWNAVRFAMSK---LGDDYTPPATLSVETMPFSCKWILSVLNKAISK 789
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 737 CSQSYSNYNFHLATAALKTFFYQYLCDTYLETTKPAIGNRS---ADAYIHV-GTLTACLSWGLQAMAPYAPFVASELLQH 812
Cdd:PLN02381 790 TVSSLDAYEFSDAASTVYSWWQYQFCDVFIEAIKPYFAGDNpefASERAAAqDTLWICLDTGLRLLHPFMPFVTEELWQR 869
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 813 VP------LNIELKLSDY-------KDEKLEEEVNEIVNICHNVRQVKSRnEISKRHHPQLSLFA--QNTDSEGVLRRHL 877
Cdd:PLN02381 870 LPqpkdhtRKDSIMISEYpsaveawTNEKVEYEMDLVLSTVKCLRSLRAE-VLEKQKNERLPAFAlcRNQEIAAIIKSHQ 948
|
890
....*....|....
gi 21355675 878 PQIKVLSRCEDVEL 891
Cdd:PLN02381 949 LEILTLANLSSLKV 962
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
43-891 |
0e+00 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 702.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 43 YQPQPVENAYWER-EHRQANLPKASASSCKrgtYRMLLPPPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDH 121
Cdd:TIGR00422 5 YDPHEVEKKWYKKwEKSGFFKPDGNSNKPP---FCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 122 AGIATQVVVERTIAAsQAKTRHELGRSAFLDEVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLF 201
Cdd:TIGR00422 82 AGIATQVKVEKKLGA-EGKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 202 EEGLIQRRNSVVNWCTALRSAISDIEVdsveITEPVEISVPGYDHKvlfgrmydfayhvvdgeaLPDGSVEEIVVSTTRP 281
Cdd:TIGR00422 161 EKGLIYRGEYLVNWDPKLNTAISDIEV----EYKEVKGKLYYIRYP------------------LANGSKDYLVVATTRP 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 282 ETILGDVAVAVHPLDPRYAKYrnIDQvKLKHPFRDDTIPLVFDITVDQEFGTGAVKITPAHDKFDFELATRHKLEPRQVF 361
Cdd:TIGR00422 219 ETMFGDTAVAVHPEDERYKHL--IGK-KVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINIL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 362 TETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKDVIEYMILPQWFLKCKDLAKDALSELHS 441
Cdd:TIGR00422 296 DEDGLLNENAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAEE 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 442 GRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAYeVIDSQGNSqWVAALDEKTARQKAMrligSEEFTLKRDPDV 521
Cdd:TIGR00422 376 GEIKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVW-YCKECGEV-YVAKEEPLPDDKTNT----GPSVELEQDTDV 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 522 LDTWFSSSLLPFSTAGWPEES--YKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSKS 599
Cdd:TIGR00422 450 LDTWFSSSLWPFSTLGWPDETkdLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKS 529
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 600 IGNIVAPQQVvqgasleslkagleqsceagiitpselkastigmtqmfpngIQECGTDALRFTLMSHNIKSHFISFDVNA 679
Cdd:TIGR00422 530 LGNVIDPLDV-----------------------------------------IEKYGADALRFTLASLVTPGDDINFDWKR 568
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 680 CHTNKLFLNKVWQAMRFTLgsakglgISLHQFETLEG--VNLGLWDRWIVGRLAETLSVCSQSYSNYNFHLATAALKTFF 757
Cdd:TIGR00422 569 VESARNFLNKLWNASRFVL-------MNLSDDLELSGgeEKLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFI 641
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 758 YQYLCDTYLETTKPAIGNRSAD---AYIHvgTLTACLSWGLQAMAPYAPFVASELLQHVP---LNIELK-----LSDYKD 826
Cdd:TIGR00422 642 WNDFCDWYIELVKYRLYNGNEAekkAARD--TLYYVLDKALRLLHPFMPFITEEIWQHFKegaDSIMLQsypvvDAEFVD 719
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21355675 827 EKLEEEVNEIVNICHNVRQVKSRNEISKRHHPQLSLFAQNTDSEGVLRRHLPQIKVLSRCEDVEL 891
Cdd:TIGR00422 720 EEAEKAFELLKEIIVSIRNLKAESNIPPNAPLKVLLIYTEAETAERLKLNAVDIKGAINFSEVEV 784
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
35-853 |
0e+00 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 637.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 35 NELPLAAGYQPQPVEnAYWEREHRQANLPKASASSCKRGTYRMLLPPPNVTGNLHLGHALMATVQDVIARQREQLGYQVD 114
Cdd:PRK14900 11 NRTELAKGYEHREVE-ARWYPFWQERGYFHGDEHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 115 WVPGTDHAGIATQVVVERTIAASQAKTRHELGRSAFLDEVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVN 194
Cdd:PRK14900 90 WLPGTDHAGIATQMIVEKELKKTEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVR 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 195 VAFERLFEEGLIQRRNSVVNWCTALRSAISDIEVDSVEITEpveisvpgydhkvlfGRMYDFAYHVVDGEAlpdgsveEI 274
Cdd:PRK14900 170 EVFVRLHEEGLIYREKKLINWCPDCRTALSDLEVEHEEAHQ---------------GELWSFAYPLADGSG-------EI 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 275 VVSTTRPETILGDVAVAVHPLDPRyakYRNIDQVKLKHPFRDDTIPLVFD-ITVDQEFGTGAVKITPAHDKFDFELATRH 353
Cdd:PRK14900 228 VVATTRPETMLGDTAVAVHPLDPR---YMALHGKKVRHPITGRTFPIVADaILVDPKFGTGAVKVTPAHDFNDFEVGKRH 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 354 KLEPRQVFTETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKDVIEYMILPQWFLKCKDLAK 433
Cdd:PRK14900 305 GLEMITVIGPDGRMTAEAGPLAGLDRFEARKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEPLAR 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 434 DALSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAYEVIDSQgnsqwvaaldEKTARQK--AMRLIGSE 511
Cdd:PRK14900 385 PAIEAVEQGRTRFIPEQWTNTYMAWMRNIHDWCISRQLWWGHQIPAWYCPDGH----------VTVARETpeACSTCGKA 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 512 EFtlKRDPDVLDTWFSSSLLPFSTAGWPEESYKER--YPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVC 589
Cdd:PRK14900 455 EL--RQDEDVLDTWFSSGLWPFSTMGWPEQTDTLRtfYPTSVMETGHDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMVR 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 590 DAHGRKMSKSIGNIVAPQQVvqgasleslkagleqsceagiitpselkastigmtqmfpngIQECGTDALRFTLMSHNIK 669
Cdd:PRK14900 533 DEKGQKMSKTKGNVIDPLVI-----------------------------------------TEQYGADALRFTLAALTAQ 571
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 670 SHFISFDVNACHTNKLFLNKVWQAMRFTLgsaKGLGISLHQFETLEGVNLGLWDRWIVGRLAETLSVCSQSYSNYNFHLA 749
Cdd:PRK14900 572 GRDIKLAKERIEGYRAFANKLWNASRFAL---MNLSGYQERGEDPARLARTPADRWILARLQRAVNETVEALEAFRFNDA 648
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 750 TAALKTFFYQYLCDTYLETTKPAIGNRSADAYIHV-GTLTACLSWGLQAMAPYAPFVASELLQHVPLNI----------- 817
Cdd:PRK14900 649 ANAVYAFVWHELCDWYIELAKEALASEDPEARRSVqAVLVHCLQTSYRLLHPFMPFITEELWHVLRAQVgasawadsvla 728
|
810 820 830
....*....|....*....|....*....|....*..
gi 21355675 818 -ELKLSDYKDEKLEEEVNEIVNICHNVRQVKSRNEIS 853
Cdd:PRK14900 729 aEYPRKGEADEAAEAAFRPVLGIIDAVRNIRGEMGIP 765
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
71-665 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 546.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 71 KRGTYRMLLPPPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQAKTRHELGRSAF 150
Cdd:pfam00133 21 GKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVVEKKLGIKEKKTRHKYGREEF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 151 LDEVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTALRSAISDIEVDS 230
Cdd:pfam00133 101 REKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGKKLVNWSPALNTALSNLEVEY 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 231 VEITEPveisvpgydhkvlfgrMYDFAYHVVDGEALpdgsveEIVVSTTRPETILGDVAVAVHPlDPRYA---------- 300
Cdd:pfam00133 181 KDVKGP----------------SIHVAFPLADDEGA------SLVIWTTTPWTLPGNTAVAVNP-EFDYVitgegyilae 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 301 -------------------KYRNIDQVKLKHPFRDDTIPLVFDITVDQEFGTGAVKITPAHDKFDFELATRHKLEPRQVF 361
Cdd:pfam00133 238 allkslykkgtdkkiledfRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 362 TETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKDVIEYMILPQWFLKCKDLAKDALSELHs 441
Cdd:pfam00133 318 DDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWFVRMDELADQALEAVE- 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 442 gRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAY------EVIDSQGNSQWVAALDEKTARQK-----AMRLIGS 510
Cdd:pfam00133 397 -KVQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWvskdteEVVCRGELFELVAGRFEEEGSIKwlhreAKDKLGY 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 511 EEFTLKRDPDVLDTWFSSSLLPFSTAGWPEES---YKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGI 587
Cdd:pfam00133 476 GKGTLEQDEDVLDTWFSSGSWPFSTLGWPFVNteeFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTGSVPFKNVLVHGL 555
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21355675 588 VCDAHGRKMSKSIGNIVAPQQVvqgasleslkagleqsceagiitpselkastigmtqmfpngIQECGTDALRFTLMS 665
Cdd:pfam00133 556 VRDEQGRKMSKSLGNVIDPLDV-----------------------------------------IDKYGADALRLWLAN 592
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
73-675 |
5.00e-178 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 522.19 E-value: 5.00e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 73 GTYRMLLPPPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQaKTRHELGRSAFLD 152
Cdd:cd00817 1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEG-KTRHDLGREEFLE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 153 EVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTALRSAISDIEVdsve 232
Cdd:cd00817 80 KCWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV---- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 233 itepveisvpgydhkvlfgrmydfayhvvdgealpdgsveeivvsttrpetilgdvavavhpldpryakyrnidqvklkh 312
Cdd:cd00817 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 313 pfrddtiplvfditvdqefgtgavkitpahdkfdfelatrhkleprqvftetglvvdayseykgiprfeardlivnrlee 392
Cdd:cd00817 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 393 mdllrqvrshtmqlpiCSRSKDVIEYMILPQWFLKCKDLAKDALSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLW 472
Cdd:cd00817 156 ----------------CSRSGDVIEPLLKPQWFVKVKDLAKKALEAVKEGDIKFVPERMEKRYENWLENIRDWCISRQLW 219
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 473 WGHQVPAYEVIDsqgNSQWVAALDEKTARQKA--MRLIGSEEFTLKRDPDVLDTWFSSSLLPFSTAGWPEES--YKERYP 548
Cdd:cd00817 220 WGHRIPAWYCKD---GGHWVVAREEDEAIDKAapEACVPCGGEELKQDEDVLDTWFSSSLWPFSTLGWPEETkdLKKFYP 296
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 549 LDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSKSIGNIVAPQQVvqgasleslkagleqscea 628
Cdd:cd00817 297 TSLLVTGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDV------------------- 357
|
570 580 590 600
....*....|....*....|....*....|....*....|....*..
gi 21355675 629 giitpselkastigmtqmfpngIQECGTDALRFTLMSHNIKSHFISF 675
Cdd:cd00817 358 ----------------------IDGYGADALRFTLASAATQGRDINL 382
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
79-993 |
9.28e-176 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 537.22 E-value: 9.28e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 79 LPPPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQAKtRHELGRSAFLDEVWRWK 158
Cdd:PLN02943 94 MPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQLVVEKMLASEGIK-RTDLGRDEFTKRVWEWK 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 159 AEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTALRSAISDIEVDSVEitEPve 238
Cdd:PLN02943 173 EKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGSYMVNWSPNLQTAVSDLEVEYSE--EP-- 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 239 isvpgydhkvlfGRMYDFAYHVVDGealpdgSVEEIVVSTTRPETILGDVAVAVHPLDPRYAKYrnIDQVKLKHPFRDDT 318
Cdd:PLN02943 249 ------------GTLYYIKYRVAGG------SEDFLTIATTRPETLFGDVAIAVNPEDDRYSKY--IGKMAIVPMTYGRH 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 319 IPLVFDITVDQEFGTGAVKITPAHDKFDFELATRHKLEPRQVFTETGLVvdaySEYKGIPRFEARDLIVNRLEEMDLLRQ 398
Cdd:PLN02943 309 VPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTL----NEVAGLYWFEAREKLWSDLEETGLAVK 384
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 399 VRSHTMQLPICSRSKDVIEYMILPQWFLKCKDLAKDALSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVP 478
Cdd:PLN02943 385 KEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKALKAVENGELTIIPERFEKIYNHWLSNIKDWCISRQLWWGHRIP 464
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 479 AYEVIDSQGNSQWVAALDEKTARQKAMRLIGsEEFTLKRDPDVLDTWFSSSLLPFSTAGWPE---ESYKERYPLDIMQTG 555
Cdd:PLN02943 465 VWYIVGKDCEEDYIVARSAEEALEKAREKYG-KDVEIYQDPDVLDTWFSSALWPFSTLGWPDvsaEDFKKFYPTTVLETG 543
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 556 HDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSKSIGNIVAPQqvvqgasleslkagleqsceagiitpse 635
Cdd:PLN02943 544 HDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPL---------------------------- 595
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 636 lkastigmtqmfpNGIQECGTDALRFTLmSHNIKSHFISFDVNACHTNKLFLNKVWQAMRFTLGSAKGLG-------ISL 708
Cdd:PLN02943 596 -------------DTIKEFGTDALRFTL-ALGTAGQDLNLSTERLTSNKAFTNKLWNAGKFVLQNLPSQSdtsawehILA 661
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 709 HQFETLEGV-NLGLWDRWIVGRLAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETTKPAI---GNRSADAYIHv 784
Cdd:PLN02943 662 CKFDKEESLlSLPLPECWVVSKLHELIDSVTTSYDKYFFGDVGREIYDFFWSDFADWYIEASKTRLyhsGDNSALSRAQ- 740
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 785 GTLTACLSWGLQAMAPYAPFVASELLQHVPLNIE-LKLSDYKDEKLEEEVNEIV---NICHNVRQVK-SRNEISKRHHPQ 859
Cdd:PLN02943 741 AVLLYVFENILKLLHPFMPFVTEELWQALPYRKEaLIVSPWPQTSLPKDLKSIKrfeNLQSLTRAIRnARAEYSVEPAKR 820
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 860 LSLF-AQNTDSEGVLRRHLPQIKVLSRCeDVELELFDESSKISKQLSYFSTAGALCSFGLKLSDGLDLTPE-----KR-D 932
Cdd:PLN02943 821 ISASiVASAEVIEYISKEKEVLALLSRL-DLQNVHFTDSPPGDANQSVHLVASEGLEAYLPLADMVDISAEverlsKRlS 899
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21355675 933 EMQkanakklkklvTELQRYRMRLDNEAFQLMADKKVKSHFENKVKELEAEIN-SLTRLAVL 993
Cdd:PLN02943 900 KMQ-----------TEYDALAARLSSPKFVEKAPEDVVRGVREKAAEAEEKIKlTKNRLAFL 950
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
80-853 |
3.98e-118 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 381.08 E-value: 3.98e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 80 PPPNVTGNLHLGHALMATVQDVIARQREQLGYQVdWVP-GTDHAGIATQVVVERT--IaasqakTRHELGRSAFLDEVWR 156
Cdd:PRK13208 45 PPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNV-FFPqGWDDNGLPTERKVEKYygI------RKDDISREEFIELCRE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 157 WKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTALRSAISDIEVDSVEITep 236
Cdd:PRK13208 118 LTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYRERE-- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 237 veisvpgydhkvlfGRMYDFAYHVVDGealpdgsvEEIVVSTTRPETILGDVAVAVHPLDPRYAKYRNidqvklKH---P 313
Cdd:PRK13208 196 --------------GKLNYIKFPVEDG--------EEIEIATTRPELLPACVAVVVHPDDERYKHLVG------KTaivP 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 314 FRDDTIPLVFDITVDQEFGTGAVKITPAHDKFDFELATRHKLEPRQVFTETGLVVDAYSEYKGIPRFEARDLIVNRLEEM 393
Cdd:PRK13208 248 LFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIIIDEDGRMTEAAGKLAGLTIEEARKKIVEDLKSG 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 394 DLLRQVRSHTMQLPICSRSKDVIEYMILPQWFLKCKDLaKDALSELhSGRLQILPPNFETEWERWLQD-SRDWCISRQ-- 470
Cdd:PRK13208 328 GLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDL-KEELLER-GKEINWYPEHMRVRLENWIEGlNWDWCISRQry 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 471 ------LWW----GHQVPAYE---VID--SQgnsqwVAALDEKTARqkamrliGSEEFTlkRDPDVLDTWFSSSLLPFST 535
Cdd:PRK13208 406 fgtpipVWYckdcGHPILPDEedlPVDptKD-----EPPGYKCPQC-------GSPGFE--GETDVMDTWATSSITPLIV 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 536 AGWPEES--YKERYPLDIMQTGHDIIFFW----VARMMMlglkLTGEAPFQRILLNGIVCDAHGRKMSKSIGNivapqqv 609
Cdd:PRK13208 472 TGWERDEdlFEKVFPMDLRPQGHDIIRTWlfytILRAYL----LTGKLPWKNIMISGMVLDPDGKKMSKSKGN------- 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 610 vqgasleslkagleqsceagIITPSELkastigmtqmfpngIQECGTDALRFTLMSHNIKSHFiSFDVNACHTNKLFLNK 689
Cdd:PRK13208 541 --------------------VVTPEEL--------------LEKYGADAVRYWAASARLGSDT-PFDEKQVKIGRRLLTK 585
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 690 VWQAMRFTLGSAKGLGISLHqfETLEGVnlglwDRWIVGRLAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETT 769
Cdd:PRK13208 586 LWNASRFVLHFSADPEPDKA--EVLEPL-----DRWILAKLAKVVEKATEALENYDFAKALEEIESFFWHVFCDDYLELV 658
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 770 K-------PAIGNRSADAYIHVgTLTAClswgLQAMAPYAPFVASELLQHVP------LNIELKLSDYKDEKLEEEVNEI 836
Cdd:PRK13208 659 KsraygedEEEEQKSARYTLYT-VLDTL----LRLLAPFLPFITEEVWSWLYggsvhrASWPEPDEELIDEEDEELGELA 733
|
810
....*....|....*..
gi 21355675 837 VNICHNVRQVKSRNEIS 853
Cdd:PRK13208 734 KEILSAVRKYKSEAGLS 750
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
81-851 |
9.19e-67 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 241.91 E-value: 9.19e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 81 PPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTD-HaGIATQVVVERT--IAASQAKtrhELGRSAFLDE---- 153
Cdd:COG0060 54 PPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGWDcH-GLPIELKVEKElgIKKKDIE---KVGIAEFREKcrey 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 154 VWRWKAE-KgagivQDLRQLGCKLNWQREYFTMD----EQQAHAvnvaFERLFEEGLIQRRNSVVNWCTALRSAISDIEV 228
Cdd:COG0060 130 ALKYVDEqR-----EDFKRLGVWGDWDNPYLTMDpeyeESIWWA----LKKLYEKGLLYKGLKPVPWCPRCGTALAEAEV 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 229 DSVEITEPveiSVpgydhkvlfgrmyDFAYHVVDGEALPDGSVEEIVVSTTRPETILGDVAVAVHP-LDprYAKYRNIDQ 307
Cdd:COG0060 201 EYKDVTSP---SI-------------YVKFPVKDEKALLLLEDAYLVIWTTTPWTLPANLAVAVHPdID--YVLVEVTGG 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 308 -----------------------------------VKLKHPFR-----DDTIPLVFD--ITVDQefGTGAVKITPAH--D 343
Cdd:COG0060 263 erlilaealveavlkelgiedyevlatfkgaelegLRYEHPFYyvvgyDRAHPVILGdyVTTED--GTGIVHTAPGHgeD 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 344 kfDFELATRHKLEPRQVFTETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKD-VIeYMILP 422
Cdd:COG0060 341 --DFEVGKKYGLPVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALLAREKITHSYPHCWRCKTpLI-YRATP 417
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 423 QWFLKCKDLAKDALSElhsgrlqilppNFETEW------ER---WLQDSRDWCISRQLWWG------------HQVPAYE 481
Cdd:COG0060 418 QWFISMDKLRDRALEA-----------IEKVNWipewgeGRfgnMLENRPDWCISRQRYWGvpipiwvcedcgELHRTEE 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 482 VIDS-------QGNSQWVAA------LDEKTARQKamrliGSEEFTlkRDPDVLDTWFSSSLLPFSTAgwpEESYKERYP 548
Cdd:COG0060 487 VIGSvaelleeEGADAWFELdlhrpfLDETLKCPK-----CGGTMR--RVPDVLDVWFDSGSMHFAVL---ENREELHFP 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 549 LD-IM----QTghdiiffwvaR-----MMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSKSIGNIVAPQQVvqgaslesl 618
Cdd:COG0060 557 ADfYLegsdQT----------RgwfysSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEV--------- 617
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 619 kagleqsceagiitpselkastigmtqmfpngIQECGTDALRFTLMSHNiKSHFISFDVNACHTNKLFLNKVWQAMRFTL 698
Cdd:COG0060 618 --------------------------------IDKYGADILRLWVASSD-YWGDLRFSDEILKEVRDVYRRLRNTYRFLL 664
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 699 GsakglgiSLHQF----ETLEGVNLGLWDRWIVGRLAETLSVCSQSYSNYNFHLATAALKTF-------FY-------QY 760
Cdd:COG0060 665 A-------NLDDFdpaeDAVPYEDLPELDRWILSRLNELIKEVTEAYDNYDFHRAYRALHNFcvedlsnWYldiskdrLY 737
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 761 lcdtyleTTKP-AIGNRSA-DAYIHVgtLTACLSWglqaMAPYAPFVASELLQHVPLNIELK--LSDY-------KDEKL 829
Cdd:COG0060 738 -------TEAAdSLDRRAAqTTLYEV--LETLVRL----LAPILPFTAEEIWQNLPGEAEESvhLADWpevdeelIDEEL 804
|
890 900
....*....|....*....|....
gi 21355675 830 EEEVNEIVNICHNVRQV--KSRNE 851
Cdd:COG0060 805 EAKWDLVREVRSAVLKAleAARKE 828
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
80-611 |
2.51e-43 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 160.28 E-value: 2.51e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 80 PPPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERtIAASQAKTRHelgRSAFLDEVWRWKA 159
Cdd:cd00668 7 PPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAER-KGGRKKKTIW---IEEFREDPKEFVE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 160 EKGAGIVQDLRQLGCKLNWQREYFTMDEqqahavnvaferlfeegliqRRNSVVNWctalrsaisdievdsveitepvei 239
Cdd:cd00668 83 EMSGEHKEDFRRLGISYDWSDEYITTEP--------------------EYSKAVEL------------------------ 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 240 svpgydhkvLFGRMYdfayhvvdgealpdgsveeivvsttrpetilgdvavavhpldpryakyrnidqvklkhpfrddti 319
Cdd:cd00668 119 ---------IFSRLY----------------------------------------------------------------- 124
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 320 plvfditvdqefgtgavkitpahdkfdfelatrhkleprqvftETGLVVDAYseykgiprfeardlivnrleemdllRQV 399
Cdd:cd00668 125 -------------------------------------------EKGLIYRGT-------------------------HPV 136
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 400 RSHtmqlpicsrskdvieymilPQWFLKCKDLAKDALSELHSGRlqILPPNFETEWERWLQDSRDWCISRQLWWGHQVPa 479
Cdd:cd00668 137 RIT-------------------EQWFFDMPKFKEKLLKALRRGK--IVPEHVKNRMEAWLESLLDWAISRQRYWGTPLP- 194
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 480 yevidsqgnsqwvaaldektarqkamrligseeftlkrdPDVLDTWFSSSLLPFSTAGWPEES--YKERYPLDIMQTGHD 557
Cdd:cd00668 195 ---------------------------------------EDVFDVWFDSGIGPLGSLGYPEEKewFKDSYPADWHLIGKD 235
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 21355675 558 IIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSKSIGNIVAPQQVVQ 611
Cdd:cd00668 236 ILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVE 289
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
81-814 |
5.73e-41 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 163.40 E-value: 5.73e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 81 PPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIaasQAKTRHELGRSAFldevwRWKAE 160
Cdd:PLN02843 40 PPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIELKVLQSL---DQEARKELTPIKL-----RAKAA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 161 KGAGIVQD-----LRQLGCKLNWQREYFTMD-EQQAHAVNVaFERLFEEGLIQRRNSVVNWCTALRSAISDIEVDSVEit 234
Cdd:PLN02843 112 KFAKKTVDtqresFKRYGVWGDWENPYLTLDpEYEAAQIEV-FGQMFLNGYIYRGRKPVHWSPSSRTALAEAELEYPE-- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 235 epveisvpGYDHKVLFgrmydFAYHVVDG---------EALPDGSVeeiVVSTTRPETILGDVAVAVHP-LD-------- 296
Cdd:PLN02843 189 --------GHVSKSIY-----VAFPVVSPsetspeeleEFLPGLSL---AIWTTTPWTMPANAAVAVNDkLQysvvevqs 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 297 ------------PRYAKYRNIDQVKL------------------------------------KHPFRDDTIPLVFD---I 325
Cdd:PLN02843 253 fsedestsggnkKKRPGNVLKEQQKLflivatdlvpaleakwgvklvvlktfpgsdlegcryIHPLYNRESPVVIGgdyI 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 326 TVdqEFGTGAVKITPAHDKFDFELATRHKLEPRQVFTETGLVVDAYSEYKGIPRF-EARDLIVNRLEEMDLLRQVRSHTM 404
Cdd:PLN02843 333 TT--ESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQFSGLSVLgEGNAAVVEALDEAGSLLMEEAYGH 410
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 405 QLPICSRSKDVIEYMILPQWFLKCKDLAKDALSELhsGRLQILPPNFETEWeRWLQDSR-DWCISRQLWWGHQVPAY--- 480
Cdd:PLN02843 411 KYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAI--DKVKWIPAQGENRI-RAMVSGRsDWCISRQRTWGVPIPVFyhv 487
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 481 ----------------EVIDSQGNSQW----VAALDEKTARQKAMRLigseeftlKRDPDVLDTWFSSSllpFSTAGWPE 540
Cdd:PLN02843 488 etkeplmneetiahvkSIVAQKGSDAWwymdVEDLLPEKYRDKASDY--------EKGTDTMDVWFDSG---SSWAGVLG 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 541 ESYKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSKSIGNIVAPQQVVQGasleslka 620
Cdd:PLN02843 557 SREGLSYPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEG-------- 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 621 GLEQSCEAGIitpselkastigmtqmfpngiqecGTDALRFTLMSHNIKShfisfDVnACHTNKL-----FLNKVWQAMR 695
Cdd:PLN02843 629 GKNQKQEPAY------------------------GADVLRLWVASVDYTG-----DV-LIGPQILkqmsdIYRKLRGTLR 678
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 696 FTLGsakglgiSLHQFETLEGV---NLGLWDRWIVGRLAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETTKPA 772
Cdd:PLN02843 679 YLLG-------NLHDWKPDNAVpyeDLPSIDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKDR 751
|
810 820 830 840
....*....|....*....|....*....|....*....|....*
gi 21355675 773 IGNRSADAYIHVG---TLTACLSWGLQAMAPYAPFVASELLQHVP 814
Cdd:PLN02843 752 LYVGGTTSFTRRScqtVLAAHLLSLLRAIAPILPHLAEDAWQNLP 796
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
675-812 |
1.10e-34 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 128.83 E-value: 1.10e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 675 FDVNACHTNKLFLNKVWQAMRFTLGSAKGLGISLHQFETLEgvnlgLWDRWIVGRLAETLSVCSQSYSNYNFHLATAALK 754
Cdd:cd07962 1 FDEKRVEGGRNFCNKLWNAARFVLMNLEDDDEPEEDPESLS-----LADRWILSRLNKTVEEVTEALENYRFSEAATALY 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 21355675 755 TFFYQYLCDTYLETTKPAIGNRSADA-YIHVGTLTACLSWGLQAMAPYAPFVASELLQH 812
Cdd:cd07962 76 EFFWNDFCDWYLELVKPRLYGEDEEEkKAARATLYYVLETILRLLHPFMPFITEELWQR 134
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
348-610 |
8.89e-34 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 133.13 E-value: 8.89e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 348 ELATRHKLEPRQVFTETGLVVDAYSEYKGI-PRFEARDL-IVNRLEEMDLL-RQVRShtMQLPICSRSkdvieymiLPQW 424
Cdd:cd00818 84 EFALRYVDEQEEQFQRLGVWVDWENPYKTMdPEYMESVWwVFKQLHEKGLLyRGYKV--VPWPLIYRA--------TPQW 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 425 FL---KCKDLAKDALSELHsgrlqILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAyevidsqgnsqWVAALDEktar 501
Cdd:cd00818 154 FIrvtKIKDRLLEANDKVN-----WIPEWVKNRFGNWLENRRDWCISRQRYWGTPIPV-----------WYCEDCG---- 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 502 qkamrligseEFTLKRDPDVLDTWFSSSLLPFSTAGWPEES--YKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPF 579
Cdd:cd00818 214 ----------EVLVRRVPDVLDVWFDSGSMPYAQLHYPFENedFEELFPADFILEGSDQTRGWFYSLLLLSTALFGKAPY 283
|
250 260 270
....*....|....*....|....*....|.
gi 21355675 580 QRILLNGIVCDAHGRKMSKSIGNIVAPQQVV 610
Cdd:cd00818 284 KNVIVHGFVLDEDGRKMSKSLGNYVDPQEVV 314
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
81-888 |
7.60e-33 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 137.93 E-value: 7.60e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 81 PPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIAtqvvVERTIAASQAKTRHE----LGRSAFLDE--- 153
Cdd:PLN02882 46 PPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGLP----VEYEIDKKLGIKRRDdvlkMGIDKYNEEcrs 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 154 -VWRWKAEKGAGIVQdlrqLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTALRSAISDIEV--DS 230
Cdd:PLN02882 122 iVTRYSKEWEKTVTR----TGRWIDFENDYKTMDPKFMESVWWVFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEAglNY 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 231 VEITEP-VEISVPgydhkvlfgrmydfayhVVDGealPDGSveEIVVSTTRPETILGDVAVAVHPlDPRYAKYRN----- 304
Cdd:PLN02882 198 KDVSDPaVMVSFP-----------------IVGD---PDNA--SFVAWTTTPWTLPSNLALCVNP-NFTYVKVRNkytgk 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 305 ----------------------------------------IDQVKLKHP--------FRDDTIPLVFDITVDQEFGTGAV 336
Cdd:PLN02882 255 vyivaesrlsalptakpkskkgskpenaaegyevlakvpgSSLVGKKYEplfdyfseFSDTAFRVVADDYVTDDSGTGVV 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 337 KITPAHDKFDFELATRHKL------EPRQVfTETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICS 410
Cdd:PLN02882 335 HCAPAFGEDDYRVCLANGIiekggnLPVPV-DDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKGRLVKSGSITHSYPFCW 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 411 RSKDVIEYMILPQWFLKCKDLaKDalselhsgrlQILPPNFETEW----------ERWLQDSRDWCISRQLWWGHQVPAY 480
Cdd:PLN02882 414 RSDTPLIYRAVPSWFVKVEEI-KD----------RLLENNKQTYWvpdyvkekrfHNWLENARDWAVSRSRFWGTPLPIW 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 481 E--------VIDSqgnsqwVAALdEKTARQKAMRL---------IGSE---EFT-LKRDPDVLDTWFSSSLLPFSTAGWP 539
Cdd:PLN02882 483 IsddgeevvVIGS------IAEL-EKLSGVKVTDLhrhfidhitIPSSrgpEFGvLRRVDDVFDCWFESGSMPYAYIHYP 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 540 ---EESYKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSKSIGNIVAPQQVvqgasle 616
Cdd:PLN02882 556 fenKELFEKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEV------- 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 617 slkagleqsceagiitpselkastigmtqmfpngIQECGTDALRFTLM-SHNIKSHFISFDVNACHT--NKLFLnKVWQA 693
Cdd:PLN02882 629 ----------------------------------IDKYGADALRLYLInSPVVRAEPLRFKEEGVFGvvKDVFL-PWYNA 673
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 694 MRFTLGSAKGLGI-SLHQFETLEGVNL----GLWDRWIVGRLAETLSVCSQSYSNYNFHLATAALKTFFYQyLCDTYLET 768
Cdd:PLN02882 674 YRFLVQNAKRLEVeGGAPFVPLDLAKLqnsaNVLDRWINSATQSLVKFVREEMGAYRLYTVVPYLVKFIDN-LTNIYVRF 752
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 769 TKPAIGNRSADAYIHVG-------TLTAClswglQAMAPYAPFVASELLQHVPLNIE--------LKLSDYK----DEKL 829
Cdd:PLN02882 753 NRKRLKGRTGEEDCRTAlstlynvLLTSC-----KVMAPFTPFFTEVLYQNLRKVLPgseesihyCSFPQVDegelDERI 827
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 830 EEEVNEIVNICHNVRQVKSRNEISKRH--------HPQLSLFAqntDSEGVLRRHLPQ---IKVLSRCED 888
Cdd:PLN02882 828 EQSVSRMQTVIELARNIRERHNKPLKTplkemvvvHPDAEFLD---DITGKLKEYVLEelnVRSLVPCND 894
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
81-625 |
3.16e-32 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 135.86 E-value: 3.16e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 81 PPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQAKTRHELGRSAFLDEVWRWKAE 160
Cdd:PTZ00427 110 PPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPIEYEIEKENNINKKEDILKMGIDVYNEKCRGIVLK 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 161 KGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTALRSAISDIEVD---------SV 231
Cdd:PTZ00427 190 YSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYVYKSFKVMPYSCKCNTPISNFELNlnykdtpdpSI 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 232 EIT-------EPVEISVPGYDHKVLFGRMYDFAYHVVDGEALPDGSVE----------EIVVSTTRPETILGDVAVAV-- 292
Cdd:PTZ00427 270 IISfvlcsdfPKVEEECNIEEDKQLLGEKYSVLYNNKRENSNNGNNNStnnvcyaqhsEILAWTTTPWTLPSNLALCVne 349
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 293 --------HPLDPR---YAKYR----------NIDQVKL-----------------------KHPFRDDTIPLVFDITVD 328
Cdd:PTZ00427 350 hftylrihHVKSNRvviVGECRlewimkelkwNVEDLKIvnrfkgkelkglrykplftnfyeKYNFKERAYKILADDFVT 429
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 329 QEFGTGAVKITPAHDKFDFELATRHK-LEPRQ-VFTE----TGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSH 402
Cdd:PTZ00427 430 DDAGTGIVHCAPTYGEDDFRVCKKNGvIDPEKnIFIDpldaNGYFTNEVEEVQNLYIKEADNVIKKKLKNENRLLSNNTI 509
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 403 TMQLPICSRSKDVIEYMILPQWFLKCKDLAKDaLSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAY-- 480
Cdd:PTZ00427 510 VHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNE-LVKNNETTYWIPAHIKEKKFHNWIKDAKDWCISRNRYWGTPIPIWad 588
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 481 EVIDSQGNSQWVAALDEKTARQKAMRL-------------IGSEEFTLKRDPDVLDTWFSSSLLPFSTAGWP----EESY 543
Cdd:PTZ00427 589 EKMETVICVESIKHLEELSGVKNINDLhrhfidhieiknpKGKTYPKLKRIPEVFDCWFESGSMPYAKVHYPfsteKEDF 668
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 544 KERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSKSIGNIVAPQQVVQGASLESLKAGLE 623
Cdd:PTZ00427 669 HKIFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLI 748
|
..
gi 21355675 624 QS 625
Cdd:PTZ00427 749 NS 750
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
723-855 |
1.35e-25 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 103.25 E-value: 1.35e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 723 DRWIVGRLAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETTKPAIGNRSADAYIhVGTLTACLSWGLQAMAPYA 802
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDSRA-QTTLYEVLETLLRLLAPFM 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 21355675 803 PFVASELLQH--VPLNIELKLSDYKDEKLEEEVNEIVNICHNVRQVKSRNEISKR 855
Cdd:pfam08264 80 PFITEELWQKesIHLAPWPEDAELEEAELEEAFELRQEIVQAIRKLRSELKIKKS 134
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
88-839 |
7.95e-21 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 98.79 E-value: 7.95e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 88 LHLGHALMATVQDVIARQREQLGYQVDW-----VPGTDHAGIAtqvvvERtIAASQAKTRHELgRSAF---LDEVWRWK- 158
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFpmafhVTGTPILGIA-----ER-IARGDPETIELY-KSLYgipEEELEKFKd 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 159 --------AEKgagIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTALRSAISD---IE 227
Cdd:PRK12300 74 peyiveyfSEE---AKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDhdlLD 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 228 VDSVEITEPVEISVPGYDHKVLfgrmydfayhvvdgealpdgsveeiVVSTTRPETILGDVAVAVHPlDPRY--AKYRN- 304
Cdd:PRK12300 151 GEEPEIVEYTLIKFEESEDLIL-------------------------PAATLRPETIFGVTNLWVNP-DATYvkAEVDGe 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 305 ---------------------IDQVK--------LKHPFRDDTIPL---VFditVDQEFGTGAVKITPAHDKFDF----- 347
Cdd:PRK12300 205 kwivskeaaeklsfqdrdveiIEEIKgseligkkVKNPVTGKEVPIlpaDF---VDPDNGTGVVMSVPAHAPYDYvalrd 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 348 ---ELATRHKLEPRQV------------------------------FTET--------GLVVDAYSEYKGIPRFEARDLI 386
Cdd:PRK12300 282 lkkNKELLDVIEPIPLievegygefpakevveklgiksqedpeleeATKEvyraefhkGVLKENTGEYAGKPVREAREKI 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 387 VNRLEEMDLLRqVRSHTMQLPICSR--SKDVIEyMILPQWFLK-----CKDLAKDALSelhsgRLQILPPNFETEWER-- 457
Cdd:PRK12300 362 TKDLIEKGIAD-IMYEFSNRPVYCRcgTECVVK-VVKDQWFIDysdpeWKELAHKALD-----NMEIIPEEYRKEFENti 434
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 458 -WLqdsRDWCISRQLWWGHQVPAYE--VIDSQGNSqwvaaldekT--------ARQKAMRLIGSEEFTlkrdPDVLDTWF 526
Cdd:PRK12300 435 dWL---KDRACARRRGLGTRLPWDEewIIESLSDS---------TiymayytiAHKIREYGIKPEQLT----PEFFDYVF 498
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 527 ---SSSLLPFSTAGWPEESYKE-R------YPLDIMQTGHDII-----FF------------WVARMMMLGLkltgeapf 579
Cdd:PRK12300 499 lgkGDPEEVSKKTGIPKEILEEmReeflywYPVDWRHSGKDLIpnhltFFifnhvaifpeekWPRGIVVNGF-------- 570
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 580 qrILLNgivcdahGRKMSKSIGNIVapqqvvqgaSLEslkagleqscEAgiitpselkastigmtqmfpngIQECGTDAL 659
Cdd:PRK12300 571 --VLLE-------GKKMSKSKGNVI---------PLR----------KA----------------------IEEYGADVV 600
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 660 RFTLMShnikshfisfdvNAchtnklflnKVWQAMRFTLGSAKGLGISLHQFETL--------EGVNLGLWDRWIVGRLA 731
Cdd:PRK12300 601 RLYLTS------------SA---------ELLQDADWREKEVESVRRQLERFYELakelieigGEEELRFIDKWLLSRLN 659
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 732 ETLSVCSQSYSnyNFHLATAALKTFF--YQYLcDTYLETTkPAIGNRSADAYIHVgtltaclsWgLQAMAPYAPFVASEL 809
Cdd:PRK12300 660 RIIKETTEAME--SFQTRDAVQEAFYelLNDL-RWYLRRV-GEANNKVLREVLEI--------W-IRLLAPFTPHLAEEL 726
|
890 900 910 920
....*....|....*....|....*....|....*....|....*..
gi 21355675 810 -----------LQHVPLNIELKLSDYKD------EKLEEEVNEIVNI 839
Cdd:PRK12300 727 whklggegfvsLEKWPEPDESKIDEEAElaeeyvKRLIEDIREILKV 773
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
51-613 |
1.55e-19 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 94.50 E-value: 1.55e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 51 AYWErEHRQANLPKASASScKRGTYRM-LLPPPNVTGnLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGI-ATQV 128
Cdd:PLN02563 91 RYWE-ENRTFRTPDDVDTS-KPKFYVLdMFPYPSGAG-LHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLpAEQY 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 129 VVErTIAASQAKTRHELGRsafldevWRwkaekgagivQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQR 208
Cdd:PLN02563 168 AIE-TGTHPKITTLKNIAR-------FR----------SQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQ 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 209 RNSVVNWCTALRSAISDIEV-DSV------------------EITEPVEISVPGYD-----------HKVLFGRMY--DF 256
Cdd:PLN02563 230 AEVPVNWCPALGTVLANEEVvDGLsergghpvirkpmrqwmlKITAYADRLLEDLDdldwpesikemQRNWIGRSEgaEL 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 257 AYHVVDGEALPDGsvEEIVVSTTRPETILGDVAVAV---HPLDPRYA---------KYR-------NIDQVKL------- 310
Cdd:PLN02563 310 DFSVLDGEGKERD--EKITVYTTRPDTLFGATYLVVapeHPLLSSLTtaeqkeaveEYVdaasrksDLERTELqkektgv 387
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 311 ------KHPFRDDTIPLVFDITVDQEFGTGAVKITPAHDKFDFELATRHKLEPRQVFT-ETGLVVDAYSEYKGiprfeaR 383
Cdd:PLN02563 388 ftgsyaINPATGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKpADGNEDDAEKAYTG------E 461
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 384 DLIVNRLEEMDLLRQVRSHTmqlpicSRSKdVIEYmilpqwflkckdlakdaLSELHSGRLQIlppNFETewerwlqdsR 463
Cdd:PLN02563 462 GVIVNSSSSGLDINGLSSKE------AAKK-VIEW-----------------LEETGNGKKKV---NYKL---------R 505
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 464 DWCISRQLWWGHQVPAYEVIDSqgnsqwvaalDEKTARQKA---MRLIGSEEFT--------LKRDPDVLDTWFSSSLLP 532
Cdd:PLN02563 506 DWLFARQRYWGEPIPVVFLEDS----------GEPVPVPESdlpLTLPELDDFTptgtgeppLAKAVSWVNTVDPSSGKP 575
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 533 F----ST----AG--W-------PEES------YKERY--PLDIMQTG--HDIIF-----FWVARMMMLGLKLTGEaPFQ 580
Cdd:PLN02563 576 ArretNTmpqwAGscWyylrfmdPKNSnalvdkEKEKYwmPVDLYVGGaeHAVLHllyarFWHKVLYDIGVVSTKE-PFQ 654
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 581 RILLNGIVC---------DAHGR---------------------------------------------KMSKSIGNIVAP 606
Cdd:PLN02563 655 CLVNQGMILgeveytafkDSDGEyvsadtadrlgelqqekipeekviksgdsfvlkddpsirliarahKMSKSRGNVVNP 734
|
....*....
gi 21355675 607 QQVV--QGA 613
Cdd:PLN02563 735 DDVVseYGA 743
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
43-613 |
1.06e-18 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 91.65 E-value: 1.06e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 43 YQPQPVEN---AYWErehrQANLPKASASScKRGTYRML--LPPPnvTGNLHLGHALMATVQDVIARQREQLGYQV---- 113
Cdd:COG0495 5 YNPKEIEKkwqKYWE----ENGTFKADEDS-SKPKYYVLdmFPYP--SGRLHMGHVRNYTIGDVVARYKRMQGYNVlhpm 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 114 DWvpgtD-------HAGIATQV----VVERTIAA--SQaktrhelgrsafldevwrwkaekgagivqdLRQLGCKLNWQR 180
Cdd:COG0495 78 GW----DafglpaeNAAIKNGVhpaeWTYENIANmrRQ------------------------------LKRLGLSYDWSR 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 181 EYFTMDE-----QQAhavnvAFERLFEEGLIQRRNSVVNWC----TAL--------RSAISDIEVdsveitEPVEIS--- 240
Cdd:COG0495 124 EIATCDPeyykwTQW-----IFLQLYEKGLAYRKEAPVNWCpvdqTVLaneqvidgRCWRCGAPV------EKKELPqwf 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 241 ----------------VPGYDHKVL------FGRMY----DFAYhvvdgealpDGSVEEIVVSTTRPETILGD--VAVAV 292
Cdd:COG0495 193 lkitdyadellddldkLDGWPEKVKtmqrnwIGRSEgaevDFPV---------EGSDEKITVFTTRPDTLFGAtfMVLAP 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 293 -HPL---------DPRYAKYrnIDQVKLK----------------------HPFRDDTIPlVFdIT--VDQEFGTGAVKI 338
Cdd:COG0495 264 eHPLvkelatpeqNAAVAAF--IEEAKKKseiertsetkektgvftglyaiNPLTGEKIP-IW-IAdyVLMDYGTGAVMA 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 339 TPAHDKFDFELATRHKLEPRQV---------------FTETGLVVDAySEYKGIPRFEARDLIVNRLEEMDLlrqvrsht 403
Cdd:COG0495 340 VPAHDQRDFEFAKKYGLPIKQViapedgddpdileeaYTGDGVLINS-GEFDGLDSEEAKEAIIEWLEEKGL-------- 410
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 404 mqlpicsrSKDVIEYmilpqwflkckdlakdalselhsgRLqilppnfetewerwlqdsRDWCISRQLWWG--------- 474
Cdd:COG0495 411 --------GKRKVNY------------------------RL------------------RDWLISRQRYWGepipiihce 440
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 475 ----HQVPAYE---------VIDSQGNS------QWVAALDEKTArQKAmrligseeftlKRDPDVLDTWFSSS------ 529
Cdd:COG0495 441 dcgvVPVPEDQlpvelpedvDFDPTGGSplarapEWVNVTCPKCG-GPA-----------RRETDTMDTFVDSSwyylry 508
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 530 LLP-FSTAGW-PEesyKERY--PLD---------IMqtgHDIIF-FWVARMMMLGLkLTGEAPFQRiLLN-GIVCD---- 590
Cdd:COG0495 509 TDPhNDEAPFdPE---AANYwlPVDqyiggiehaIL---HLLYArFFTKVLRDLGL-VSFDEPFKR-LLTqGMVLEvgkd 580
|
730 740
....*....|....*....|....*....
gi 21355675 591 ----AHGRKMSKSIGNIVAPQQVVQ--GA 613
Cdd:COG0495 581 gvviGGIEKMSKSKGNVVDPDEIIEkyGA 609
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
268-391 |
1.79e-13 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 69.88 E-value: 1.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 268 DGSVEEIVVSTTRPETILGD--VAVAV-HPL-------DPRYAKY----RNIDQ----------------VKLKHPFRDD 317
Cdd:pfam13603 17 EGTDEKIEVFTTRPDTLMGVtfVALAPeHPLveklaekNPEVAAFieecKNTSEiertsetkekegvftgLYAIHPITGE 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 318 TIPL-----VFDitvdqEFGTGAVKITPAHDKFDFELATRHKLEPRQV----------------FTETGLVVDAySEYKG 376
Cdd:pfam13603 97 KIPIwianfVLM-----EYGTGAVMAVPAHDQRDFEFAKKYNLPIKPViqpedgdldldimteaYTEEGILVNS-GEFDG 170
|
170
....*....|....*
gi 21355675 377 IPRFEARDLIVNRLE 391
Cdd:pfam13603 171 LDSEEAKEAIIKKLE 185
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
419-613 |
3.74e-12 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 68.43 E-value: 3.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 419 MILPQWFLKC-----KDLAKDALSelhsgRLQILPPNFETEWERWLQdsrdwcISRQLWWGHQVPAYEVIDSQGNSQW-- 491
Cdd:cd00812 127 KLLDQWFLKYsetewKEKLLKDLE-----KLDGWPEEVRAMQENWIG------CSRQRYWGTPIPWTDTMESLSDSTWyy 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 492 ----VAALDEKTarqkamrligsEEFTLKRDPDVLDTWfsssllpfstagwpeesykerYPLDIMQTGHDII-------- 559
Cdd:cd00812 196 arytDAHNLEQP-----------YEGDLEFDREEFEYW---------------------YPVDIYIGGKEHApnhllysr 243
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 21355675 560 FFWVArmmMLGLKLTGEAPFQRILLNGIVCdAHGRKMSKSIGNIVAPQQVVQ--GA 613
Cdd:cd00812 244 FNHKA---LFDEGLVTDEPPKGLIVQGMVL-LEGEKMSKSKGNVVTPDEAIKkyGA 295
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
77-216 |
1.77e-09 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 60.34 E-value: 1.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 77 MLLPPPNvtGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDhagiATQVVVERtiAASQAKTRHElgrsafldevwR 156
Cdd:cd00812 6 VMFPYPS--GALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFD----AFGLPAEN--AAIKIGRDPE-----------D 66
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 157 WKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWC 216
Cdd:cd00812 67 WTEYNIKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC 126
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
694-836 |
6.12e-07 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 50.60 E-value: 6.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 694 MRFTLGSakglgisLHQFETLEGV----NLGLWDRWIVGRLAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETT 769
Cdd:cd07960 20 FRFLLGN-------LNDFDPAKDAvpyeELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCTVDLSAFYLDII 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 770 K-----PAIGN---RSADAYIHVgTLTACLSWglqaMAPYAPFVASELLQHVPLNIELK----------LSDYKDEKLEE 831
Cdd:cd07960 93 KdrlycDAKDSlerRSAQTVLYH-ILDALLKL----LAPILPFTAEEVWEHLPGEKKEEsvfledwpelPEEWKDEELEE 167
|
....*
gi 21355675 832 EVNEI 836
Cdd:cd07960 168 KWEKL 172
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
407-611 |
1.09e-06 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 51.91 E-value: 1.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 407 PICSRSKDVIEYMILPQWFLKCKDLAKDALSELHSGRLQiLPPNFETEWERWLQDS-RDWCISRQLWWGHQVPAYE---- 481
Cdd:pfam09334 167 PKCVICGTTPEVKETEHYFFDLSKFQDKLREWIEENNPE-WPENVKNMVLEWLKEGlKDRAISRDLDWGIPVPGAEgkvf 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 482 -VidsqgnsqWVAAldektarqkamrLIGSEEFT--LKRDPDVLDTWfsssllpfstagWPEESYKERYPLdimqTGHDI 558
Cdd:pfam09334 246 yV--------WLDA------------PIGYISATkeLSGNEEKWKEW------------WPNDPDTELVHF----IGKDI 289
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 21355675 559 IFF----WVARMMMLGLKLtgeaPfQRILLNGIVcDAHGRKMSKSIGNIVAPQQVVQ 611
Cdd:pfam09334 290 IYFhtifWPAMLLGAGYRL----P-TTVFAHGYL-TYEGGKMSKSRGNVVWPSEALD 340
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
417-611 |
1.42e-06 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 51.38 E-value: 1.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 417 EYMILPQWFLKCKDLAKDALSELHSGRLQILPPNFETEWERWLQDS-RDWCISRQLW-WGHQVPAYE-----Vidsqgns 489
Cdd:cd00814 133 EWREEEHYFFRLSKFQDRLLEWLEKNPDFIWPENARNEVLSWLKEGlKDLSITRDLFdWGIPVPLDPgkviyV------- 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 490 qWVAAldektarqkamrLIGSEEFTLKRDPDVLDTWFSSSllpfstaGWPEESYkerypldIMqtGHDIIFF----WVAR 565
Cdd:cd00814 206 -WFDA------------LIGYISATGYYNEEWGNSWWWKD-------GWPELVH-------FI--GKDIIRFhaiyWPAM 256
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 21355675 566 MMMLGLKLtgeapFQRILLNG-IVCDahGRKMSKSIGNIVAPQQVVQ 611
Cdd:cd00814 257 LLGAGLPL-----PTRIVAHGyLTVE--GKKMSKSRGNVVDPDDLLE 296
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
518-619 |
2.10e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 51.42 E-value: 2.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 518 DPD-VLDTWFS------SSLLPFSTAGWPEESYKERYPLDIMQTGHDIIFF----WVARMMMLGLKLtgeapFQRILLNG 586
Cdd:PRK11893 217 DPKhVIYVWFDaltnylTALGYPDDEELLAELFNKYWPADVHLIGKDILRFhavyWPAFLMAAGLPL-----PKRVFAHG 291
|
90 100 110
....*....|....*....|....*....|....
gi 21355675 587 -IVCDahGRKMSKSIGNIVAPQQVVQGASLESLK 619
Cdd:PRK11893 292 fLTLD--GEKMSKSLGNVIDPFDLVDEYGVDAVR 323
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
80-206 |
1.02e-05 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 49.30 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 80 PPPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQvvverTIAASQAKTRHELgrsafldeVWRWKA 159
Cdd:TIGR00398 6 ALPYANGKPHLGHAYTTILADVYARYKRLRGYEVLFVCGTDEHGTKIE-----LKAEQEGLTPKEL--------VDKYHE 72
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 21355675 160 EkgagIVQDLRQLGckLNWQREYFTMDEQQAHAVNVAFERLFEEGLI 206
Cdd:TIGR00398 73 E----FKDDWKWLN--ISFDRFIRTTDEEHKEIVQKIFQKLKENGYI 113
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
515-611 |
1.12e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 49.41 E-value: 1.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 515 LKRDPD-VLDTWFSSsLLPFSTA-GWP---EESYKERYPLDIMQTGHDII-F---FWVARMMMLGLKLtgeapFQRILln 585
Cdd:PRK12267 217 VPFDPKhVVYVWIDA-LLNYITAlGYGsddDELFKKFWPADVHLVGKDILrFhaiYWPIMLMALGLPL-----PKKVF-- 288
|
90 100 110
....*....|....*....|....*....|..
gi 21355675 586 givcdAHG------RKMSKSIGNIVAPQQVVQ 611
Cdd:PRK12267 289 -----AHGwwlmkdGKMSKSKGNVVDPEELVD 315
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
82-206 |
1.21e-05 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 48.30 E-value: 1.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 82 PNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVvertiAASQAKTRHELG--RSAFLDEVWRWka 159
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQK-----AEEEGVTPQELCdkYHEIFKDLFKW-- 81
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 21355675 160 ekgAGIVQDlrqlgcklnwqreYF--TMDEQQAHAVNVAFERLFEEGLI 206
Cdd:cd00814 82 ---LNISFD-------------YFirTTSPRHKEIVQEFFKKLYENGYI 114
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
80-206 |
1.48e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 48.72 E-value: 1.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 80 PPPNVTGNLHLGHALMATVQDVIAR-QReQLGYQVDWVPGTDHAGiatQVVvertiaasqAKTRHELGRS--AFLDEVwr 156
Cdd:PRK11893 8 PIYYPNGKPHIGHAYTTLAADVLARfKR-LRGYDVFFLTGTDEHG---QKI---------QRKAEEAGISpqELADRN-- 72
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 21355675 157 wkaekGAGIVQDLRQLGCKL-NWQReyfTMDEQQAHAVNVAFERLFEEGLI 206
Cdd:PRK11893 73 -----SAAFKRLWEALNISYdDFIR---TTDPRHKEAVQEIFQRLLANGDI 115
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
79-206 |
1.12e-04 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 45.87 E-value: 1.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 79 LPPPNvtGNLHLGHAlMATVQ-DVIARQREQLGYQVDWVPGTD-HaGIATQvvvertIAASQAktrhelGRS--AFLDEV 154
Cdd:COG0143 9 IPYAN--GPPHIGHL-YTYIPaDILARYQRLRGHDVLFVTGTDeH-GTKIE------LAAEKE------GITpqELVDRI 72
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 21355675 155 WrwkaekgAGIVQDLRQLGCKL-NWQReyfTMDEQQAHAVNVAFERLFEEGLI 206
Cdd:COG0143 73 H-------AEFKELFEKLGISFdNFIR---TTSPEHKELVQEIFQRLYDNGDI 115
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
82-218 |
1.65e-04 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 44.97 E-value: 1.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 82 PNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVvvertiaasQAKtrhELGRSAfldevwrwkAEK 161
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIEL---------KAE---KEGITP---------EEL 66
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 21355675 162 GAGIVQDLRQLGCKLNWQREYF--TMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTA 218
Cdd:pfam09334 67 VDRYHEIHREDFKKFNISFDDYgrTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPS 125
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
84-206 |
6.70e-04 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 43.64 E-value: 6.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 84 VTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGiatQVVVErtIAASQAKTRHElgrsaFLDEvwrwkaekga 163
Cdd:PRK12267 15 PNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHG---QKIQQ--AAEKAGKTPQE-----YVDE---------- 74
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 21355675 164 gIVQDLRQLGCKLNWQREYF--TMDEQQAHAVNVAFERLFEEGLI 206
Cdd:PRK12267 75 -ISAGFKELWKKLDISYDKFirTTDERHKKVVQKIFEKLYEQGDI 118
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
715-809 |
1.84e-03 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 39.11 E-value: 1.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355675 715 EGVNLGLWDRWIVGRLAETLSVCSQSYSNYNFHlatAALKTFFYQYLCDT--YLETTKPAIGNRSADAYIHVGTLtacls 792
Cdd:cd07959 29 ELEELTFIDRWLLSRLNRLIKETTEAYENMQFR---EALKEGLYELQNDLdwYRERGGAGMNKDLLRRFIEVWTR----- 100
|
90
....*....|....*..
gi 21355675 793 wglqAMAPYAPFVASEL 809
Cdd:cd07959 101 ----LLAPFAPHLAEEI 113
|
|
|