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Conserved domains on  [gi|24660591|ref|NP_648171|]
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uncharacterized protein Dmel_CG7565 [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
myxo_dep_M36 super family cl45606
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 428-810 8.60e-30

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


The actual alignment was detected with superfamily member NF038112:

Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 128.62  E-value: 8.60e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   428 NQPPqVIISPREQIIRQPTTnAILDGSTSTD-DDKITNWHWEVISGPigyqPV-LPEVNTLQLDLTSP-----GNYTFKL 500
Cdd:NF038112 1185 NRRP-VANAGPDQTVLERTT-VTLNGSGSFDpDGDPLTYAWTQVSGP----AVtLTGADTATPSFTAPevtadTVLTFQL 1258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   501 TVTDSNNVTNSTTATIAVLKeTDYAPVANAGDAVILYlPNNNVTLNGTASSDDHEIVAWEWTKdASDEAKAVDMQNTRTP 580
Cdd:NF038112 1259 VVSDGTKTSAPDTVTVLVRN-VNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWTQ-TSGPAVTLTGATTATA 1335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   581 -YVQLSNLEEGMYTFVLKVTDGSgQSSTAKVHVFVKPpTNSPPVAEAGSNTTTSlPINWVLLNGSDSKDDIGIKSYLWKQ 659
Cdd:NF038112 1336 tFTAPEVTADTQLTFTLTVSDGT-ASATDTVTVTVRN-VNRAPVANAGADQTVD-ERSTVTLSGSATDPDGDALTYAWTQ 1412

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   660 LSGP-------NNAVILKSNSSIANATSLTlglyeFELTVADENNNTATDTTWVkIVQERNAAPIANAGGDHTVTlPATA 732
Cdd:NF038112 1413 TAGPtvtltgaDTATASFTAPEVAADTELT-----FQLTVSADGQASADVTVTV-TVRNVNRAPVAHAGESITVD-EGST 1485

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   733 IYFNGSKSWDDLAVVKYLWTRdehslAAG--VIVADTDKEPVMILTNLVQG--RYVFTLTVSDDQGLTSSDTVSVNVRRD 808
Cdd:NF038112 1486 VTLDASATDPDGDTLTYAWTQ-----VAGpsVTLTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNV 1560


                  ..
gi 24660591   809 PK 810
Cdd:NF038112 1561 NR 1562
MANEC super family cl06508
MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the ...
 52-153 2.76e-19

MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins. Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors.


The actual alignment was detected with superfamily member smart00765:

Pssm-ID: 471454  Cd Length: 93  Bit Score: 83.65  E-value: 2.76e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591      52 SPNLVCHKMlRHVFENATPRDEQQAGVFEEYKPPPDAVEPLEEeaylwnCLQACCEKPRngssaCNVVLVF------KAK 125
Cdd:smart00765    1 SPGEDCLGR-FRVLENAIIRTEESLSAGARFLKSPIAVNTWED------CVRACCSTPN-----CNLAVFElrredaEGN 68

                            90       100       110
                    ....*....|....*....|....*....|
gi 24660591     126 CYHIRC--QSNEAClpKLRvrmPNEKVQMV 153
Cdd:smart00765   69 CYLFNCtyPGKEVC--KFK---PHEGYTSY 93
 
Name Accession Description Interval E-value
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 428-810 8.60e-30

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 128.62  E-value: 8.60e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   428 NQPPqVIISPREQIIRQPTTnAILDGSTSTD-DDKITNWHWEVISGPigyqPV-LPEVNTLQLDLTSP-----GNYTFKL 500
Cdd:NF038112 1185 NRRP-VANAGPDQTVLERTT-VTLNGSGSFDpDGDPLTYAWTQVSGP----AVtLTGADTATPSFTAPevtadTVLTFQL 1258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   501 TVTDSNNVTNSTTATIAVLKeTDYAPVANAGDAVILYlPNNNVTLNGTASSDDHEIVAWEWTKdASDEAKAVDMQNTRTP 580
Cdd:NF038112 1259 VVSDGTKTSAPDTVTVLVRN-VNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWTQ-TSGPAVTLTGATTATA 1335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   581 -YVQLSNLEEGMYTFVLKVTDGSgQSSTAKVHVFVKPpTNSPPVAEAGSNTTTSlPINWVLLNGSDSKDDIGIKSYLWKQ 659
Cdd:NF038112 1336 tFTAPEVTADTQLTFTLTVSDGT-ASATDTVTVTVRN-VNRAPVANAGADQTVD-ERSTVTLSGSATDPDGDALTYAWTQ 1412

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   660 LSGP-------NNAVILKSNSSIANATSLTlglyeFELTVADENNNTATDTTWVkIVQERNAAPIANAGGDHTVTlPATA 732
Cdd:NF038112 1413 TAGPtvtltgaDTATASFTAPEVAADTELT-----FQLTVSADGQASADVTVTV-TVRNVNRAPVAHAGESITVD-EGST 1485

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   733 IYFNGSKSWDDLAVVKYLWTRdehslAAG--VIVADTDKEPVMILTNLVQG--RYVFTLTVSDDQGLTSSDTVSVNVRRD 808
Cdd:NF038112 1486 VTLDASATDPDGDTLTYAWTQ-----VAGpsVTLTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNV 1560


                  ..
gi 24660591   809 PK 810
Cdd:NF038112 1561 NR 1562
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 400-716 2.90e-25

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 113.98  E-value: 2.90e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   400 TFKVTVTgdNGTFGEATANVTVLPENrINQPPQVIISPREQII-RQPTTnaiLDGSTSTDDDKITNWHWEVISGPigyQP 478
Cdd:NF038112 1255 TFQLVVS--DGTKTSAPDTVTVLVRN-VNRAPVAVAGAPATVDeRSTVT---LDGSGTDADGDALTYAWTQTSGP---AV 1325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   479 VLPEVNTLQLDLTSP-----GNYTFKLTVTDSnnvTNSTTATIAV-LKETDYAPVANAGdAVILYLPNNNVTLNGTASSD 552
Cdd:NF038112 1326 TLTGATTATATFTAPevtadTQLTFTLTVSDG---TASATDTVTVtVRNVNRAPVANAG-ADQTVDERSTVTLSGSATDP 1401

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   553 DHEIVAWEWTKDASdEAKAVDMQNTRTP-YVQLSNLEEGMYTFVLKVTDGSGQSSTAKVHVFVKPPtNSPPVAEAGsNTT 631
Cdd:NF038112 1402 DGDALTYAWTQTAG-PTVTLTGADTATAsFTAPEVAADTELTFQLTVSADGQASADVTVTVTVRNV-NRAPVAHAG-ESI 1478

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   632 TSLPINWVLLNGSDSKDDIGIKSYLWKQLSGPnnAVILKSNSS---------IANATSLTlglyeFELTVADENNNTATD 702
Cdd:NF038112 1479 TVDEGSTVTLDASATDPDGDTLTYAWTQVAGP--SVTLTGADSakltftapeVSADTTLT-----FSLTVTDGSGSSGPV 1551

                         330
                  ....*....|....
gi 24660591   703 TTWVKiVQERNAAP 716
Cdd:NF038112 1552 VVTVT-VKNVNRAP 1564
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 346-636 1.86e-19

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 94.72  E-value: 1.86e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   346 VTLAAF-TVPDEQTSDtkykYLWTLISQPKGPMNGTISDQSKSKVKLSNLSEGLyTFKVTVTgDNGTFGEATANVTVLPe 424
Cdd:NF038112 1299 VTLDGSgTDADGDALT----YAWTQTSGPAVTLTGATTATATFTAPEVTADTQL-TFTLTVS-DGTASATDTVTVTVRN- 1371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   425 nrINQPPqVIISPREQIIRQPTTnAILDGSTSTDDDKITNWHWEVISGPigyQPVLPEVNTLQLDLTSPG-----NYTFK 499
Cdd:NF038112 1372 --VNRAP-VANAGADQTVDERST-VTLSGSATDPDGDALTYAWTQTAGP---TVTLTGADTATASFTAPEvaadtELTFQ 1444

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   500 LTVTDSNNVTNSTTATIAVLKeTDYAPVANAGDAvILYLPNNNVTLNGTASSDDHEIVAWEWTKDAsdeAKAVDMQNTRT 579
Cdd:NF038112 1445 LTVSADGQASADVTVTVTVRN-VNRAPVAHAGES-ITVDEGSTVTLDASATDPDGDTLTYAWTQVA---GPSVTLTGADS 1519

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24660591   580 PYVQLSNLEEGMYT---FVLKVTDGSGQSSTAKVHVFVKPPTNSPP---VAEAGSNTTTSLPI 636
Cdd:NF038112 1520 AKLTFTAPEVSADTtltFSLTVTDGSGSSGPVVVTVTVKNVNRAPDgggCSSTGGSPGGMLPL 1582
MANEC smart00765
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is ...
 52-153 2.76e-19

The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase.


Pssm-ID: 129004  Cd Length: 93  Bit Score: 83.65  E-value: 2.76e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591      52 SPNLVCHKMlRHVFENATPRDEQQAGVFEEYKPPPDAVEPLEEeaylwnCLQACCEKPRngssaCNVVLVF------KAK 125
Cdd:smart00765    1 SPGEDCLGR-FRVLENAIIRTEESLSAGARFLKSPIAVNTWED------CVRACCSTPN-----CNLAVFElrredaEGN 68

                            90       100       110
                    ....*....|....*....|....*....|
gi 24660591     126 CYHIRC--QSNEAClpKLRvrmPNEKVQMV 153
Cdd:smart00765   69 CYLFNCtyPGKEVC--KFK---PHEGYTSY 93
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 364-622 4.67e-10

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 63.29  E-value: 4.67e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591    364 KYLWTLISQPKGpmNGTISDQSKSKVKLS-------NLSEGLYTFKVTVT--GDNGTFGEATANVTVLPEN---RINQPP 431
Cdd:pfam02010   15 DYLWSVFTVSSN--LNLQTISSPKDLVLPqltipsgTLPYGTYVFTLTVSlsSTPSLAGTDIITVTVQPSPlvaVIDGGS 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591    432 QVIISPREQIIrqpttnaiLDGSTSTDDDK----ITNW--HWEVISGPIGYQPVL-------PEVNTLQLD------LTS 492
Cdd:pfam02010   93 SRVVGYNQDLT--------LDGSESYDPDVdpgsSSGLtyLWSCRRSSSGDNPLLnndpvcfSDQNEGTLLqstsssLTI 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591    493 PGN-------YTFKLTVTDSNNVTNSTTATIAVLKETDY----APVANAGDavILYLPNNNV--TLNGTASSDDHEIVAW 559
Cdd:pfam02010  165 PAStlqanvtYTFKLTVSKGSRNSASTTQTILVVDGNPPiiilSCISNCNR--KNNPVDRLVllASTCLNCSSDLSDVTY 242

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24660591    560 EWTKDASDEAKAV---DMQNTRT----PYVQL--SNLEEGM-YTFVLKVTDGSGQSSTAKVHVFVkppTNSPP 622
Cdd:pfam02010  243 RWLSLGSENTSLVldqLNSQTSTgrsgPYLVIkaGVLQSGVsYRFTLIVTVYPGLVSGLASISFI---TNAPP 312
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 700-809 1.37e-06

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 52.74  E-value: 1.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   700 ATDTTWVKIVQER---NAAPIANAGGDHTVtLPATAIYFNGSKSWD-DLAVVKYLWTR---------DEHSLAAGVIVAD 766
Cdd:NF038112 1169 ITNTPFTSLVAEPgvcNRRPVANAGPDQTV-LERTTVTLNGSGSFDpDGDPLTYAWTQvsgpavtltGADTATPSFTAPE 1247

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 24660591   767 TDKEpvmilTNLVqgryvFTLTVSDDQGLTSSDTVSV---NVRRDP 809
Cdd:NF038112 1248 VTAD-----TVLT-----FQLVVSDGTKTSAPDTVTVlvrNVNRAP 1283
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
491-752 1.41e-06

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 51.59  E-value: 1.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591  491 TSPGNYTFKLTVTDSNNVTNSTTATIAVLKETDYAPVANAGDAVILYLPNNNVTL-------NGTASSDDHEIVAWEWTK 563
Cdd:COG3291   47 TTPGTYTVTLTVTDAAGCSDTTTKTITVGAPNPGVTTVTTSTTVTTLANTANGGAttvvagsTVGTGVATSTTTAAAPGG 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591  564 DASDEAKAVDMQNTRTPYVQLSNLEEGMYTFVLKVTDGSGQSSTAKVHVFVKPPTNSPPVAEAGSNTTTSLPINWVLLNG 643
Cdd:COG3291  127 GGGTGTTTTTGTDTGLTGSTGTASDTATVTTSVSTTDVTSDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSG 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591  644 SDSKDDIGIKSYLWKQLSGPNNAVILKSNSSIANATSLTLGLYEFELTVADENNNTATDTTWVKIVQERNAAPIANAGGD 723
Cdd:COG3291  207 TAGVTTGATSGTSGTGSATSGVAVTDVTLTGISTGDAGTPGTNTVTTSGANTAGTSTITGGTSGVVTTSAATGTSTNGTG 286

                        250       260
                 ....*....|....*....|....*....
gi 24660591  724 HTVTLPATAIYFNGSKSWDDLAVVKYLWT 752
Cdd:COG3291  287 GLGTTTAITPGNVSTTADVTGGTATLAVS 315
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 454-518 8.46e-06

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 44.75  E-value: 8.46e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24660591     454 STSTDDDKITNWHWEVISGPIGYQPvlpevnTLQLDLTSPGNYTFKLTVTDSNNvTNSTTATIAV 518
Cdd:smart00089   21 ATSSDDGSIVSYTWDFGDGTSSTGP------TVTHTYTKPGTYTVTLTVTNAVG-SASATVTVVV 78
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 716-805 1.11e-05

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 44.41  E-value: 1.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591  716 PIANAGGDHTVTLPATaIYFNGSkSWDDLAVVKYLWTRDEHSLaagvivaDTDKEPVMILTNLVQGRYVFTLTVSDDQGL 795
Cdd:cd00146    1 PTASVSAPPVAELGAS-VTFSAS-DSSGGSIVSYKWDFGDGEV-------SSSGEPTVTHTYTKPGTYTVTLTVTNAVGS 71

                         90
                 ....*....|
gi 24660591  796 TSSDTVSVNV 805
Cdd:cd00146   72 SSTKTTTVVV 81
 
Name Accession Description Interval E-value
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 428-810 8.60e-30

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 128.62  E-value: 8.60e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   428 NQPPqVIISPREQIIRQPTTnAILDGSTSTD-DDKITNWHWEVISGPigyqPV-LPEVNTLQLDLTSP-----GNYTFKL 500
Cdd:NF038112 1185 NRRP-VANAGPDQTVLERTT-VTLNGSGSFDpDGDPLTYAWTQVSGP----AVtLTGADTATPSFTAPevtadTVLTFQL 1258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   501 TVTDSNNVTNSTTATIAVLKeTDYAPVANAGDAVILYlPNNNVTLNGTASSDDHEIVAWEWTKdASDEAKAVDMQNTRTP 580
Cdd:NF038112 1259 VVSDGTKTSAPDTVTVLVRN-VNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWTQ-TSGPAVTLTGATTATA 1335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   581 -YVQLSNLEEGMYTFVLKVTDGSgQSSTAKVHVFVKPpTNSPPVAEAGSNTTTSlPINWVLLNGSDSKDDIGIKSYLWKQ 659
Cdd:NF038112 1336 tFTAPEVTADTQLTFTLTVSDGT-ASATDTVTVTVRN-VNRAPVANAGADQTVD-ERSTVTLSGSATDPDGDALTYAWTQ 1412

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   660 LSGP-------NNAVILKSNSSIANATSLTlglyeFELTVADENNNTATDTTWVkIVQERNAAPIANAGGDHTVTlPATA 732
Cdd:NF038112 1413 TAGPtvtltgaDTATASFTAPEVAADTELT-----FQLTVSADGQASADVTVTV-TVRNVNRAPVAHAGESITVD-EGST 1485

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   733 IYFNGSKSWDDLAVVKYLWTRdehslAAG--VIVADTDKEPVMILTNLVQG--RYVFTLTVSDDQGLTSSDTVSVNVRRD 808
Cdd:NF038112 1486 VTLDASATDPDGDTLTYAWTQ-----VAGpsVTLTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNV 1560


                  ..
gi 24660591   809 PK 810
Cdd:NF038112 1561 NR 1562
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 400-716 2.90e-25

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 113.98  E-value: 2.90e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   400 TFKVTVTgdNGTFGEATANVTVLPENrINQPPQVIISPREQII-RQPTTnaiLDGSTSTDDDKITNWHWEVISGPigyQP 478
Cdd:NF038112 1255 TFQLVVS--DGTKTSAPDTVTVLVRN-VNRAPVAVAGAPATVDeRSTVT---LDGSGTDADGDALTYAWTQTSGP---AV 1325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   479 VLPEVNTLQLDLTSP-----GNYTFKLTVTDSnnvTNSTTATIAV-LKETDYAPVANAGdAVILYLPNNNVTLNGTASSD 552
Cdd:NF038112 1326 TLTGATTATATFTAPevtadTQLTFTLTVSDG---TASATDTVTVtVRNVNRAPVANAG-ADQTVDERSTVTLSGSATDP 1401

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   553 DHEIVAWEWTKDASdEAKAVDMQNTRTP-YVQLSNLEEGMYTFVLKVTDGSGQSSTAKVHVFVKPPtNSPPVAEAGsNTT 631
Cdd:NF038112 1402 DGDALTYAWTQTAG-PTVTLTGADTATAsFTAPEVAADTELTFQLTVSADGQASADVTVTVTVRNV-NRAPVAHAG-ESI 1478

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   632 TSLPINWVLLNGSDSKDDIGIKSYLWKQLSGPnnAVILKSNSS---------IANATSLTlglyeFELTVADENNNTATD 702
Cdd:NF038112 1479 TVDEGSTVTLDASATDPDGDTLTYAWTQVAGP--SVTLTGADSakltftapeVSADTTLT-----FSLTVTDGSGSSGPV 1551

                         330
                  ....*....|....
gi 24660591   703 TTWVKiVQERNAAP 716
Cdd:NF038112 1552 VVTVT-VKNVNRAP 1564
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 346-636 1.86e-19

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 94.72  E-value: 1.86e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   346 VTLAAF-TVPDEQTSDtkykYLWTLISQPKGPMNGTISDQSKSKVKLSNLSEGLyTFKVTVTgDNGTFGEATANVTVLPe 424
Cdd:NF038112 1299 VTLDGSgTDADGDALT----YAWTQTSGPAVTLTGATTATATFTAPEVTADTQL-TFTLTVS-DGTASATDTVTVTVRN- 1371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   425 nrINQPPqVIISPREQIIRQPTTnAILDGSTSTDDDKITNWHWEVISGPigyQPVLPEVNTLQLDLTSPG-----NYTFK 499
Cdd:NF038112 1372 --VNRAP-VANAGADQTVDERST-VTLSGSATDPDGDALTYAWTQTAGP---TVTLTGADTATASFTAPEvaadtELTFQ 1444

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   500 LTVTDSNNVTNSTTATIAVLKeTDYAPVANAGDAvILYLPNNNVTLNGTASSDDHEIVAWEWTKDAsdeAKAVDMQNTRT 579
Cdd:NF038112 1445 LTVSADGQASADVTVTVTVRN-VNRAPVAHAGES-ITVDEGSTVTLDASATDPDGDTLTYAWTQVA---GPSVTLTGADS 1519

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24660591   580 PYVQLSNLEEGMYT---FVLKVTDGSGQSSTAKVHVFVKPPTNSPP---VAEAGSNTTTSLPI 636
Cdd:NF038112 1520 AKLTFTAPEVSADTtltFSLTVTDGSGSSGPVVVTVTVKNVNRAPDgggCSSTGGSPGGMLPL 1582
MANEC smart00765
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is ...
 52-153 2.76e-19

The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase.


Pssm-ID: 129004  Cd Length: 93  Bit Score: 83.65  E-value: 2.76e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591      52 SPNLVCHKMlRHVFENATPRDEQQAGVFEEYKPPPDAVEPLEEeaylwnCLQACCEKPRngssaCNVVLVF------KAK 125
Cdd:smart00765    1 SPGEDCLGR-FRVLENAIIRTEESLSAGARFLKSPIAVNTWED------CVRACCSTPN-----CNLAVFElrredaEGN 68

                            90       100       110
                    ....*....|....*....|....*....|
gi 24660591     126 CYHIRC--QSNEAClpKLRvrmPNEKVQMV 153
Cdd:smart00765   69 CYLFNCtyPGKEVC--KFK---PHEGYTSY 93
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 364-622 4.67e-10

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 63.29  E-value: 4.67e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591    364 KYLWTLISQPKGpmNGTISDQSKSKVKLS-------NLSEGLYTFKVTVT--GDNGTFGEATANVTVLPEN---RINQPP 431
Cdd:pfam02010   15 DYLWSVFTVSSN--LNLQTISSPKDLVLPqltipsgTLPYGTYVFTLTVSlsSTPSLAGTDIITVTVQPSPlvaVIDGGS 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591    432 QVIISPREQIIrqpttnaiLDGSTSTDDDK----ITNW--HWEVISGPIGYQPVL-------PEVNTLQLD------LTS 492
Cdd:pfam02010   93 SRVVGYNQDLT--------LDGSESYDPDVdpgsSSGLtyLWSCRRSSSGDNPLLnndpvcfSDQNEGTLLqstsssLTI 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591    493 PGN-------YTFKLTVTDSNNVTNSTTATIAVLKETDY----APVANAGDavILYLPNNNV--TLNGTASSDDHEIVAW 559
Cdd:pfam02010  165 PAStlqanvtYTFKLTVSKGSRNSASTTQTILVVDGNPPiiilSCISNCNR--KNNPVDRLVllASTCLNCSSDLSDVTY 242

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24660591    560 EWTKDASDEAKAV---DMQNTRT----PYVQL--SNLEEGM-YTFVLKVTDGSGQSSTAKVHVFVkppTNSPP 622
Cdd:pfam02010  243 RWLSLGSENTSLVldqLNSQTSTgrsgPYLVIkaGVLQSGVsYRFTLIVTVYPGLVSGLASISFI---TNAPP 312
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 713-805 2.39e-08

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 52.27  E-value: 2.39e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591    713 NAAPIANAGGDHTVTLPATAIyFNGSKSWD-DLAVVKYLWTRDEHSLAAGVIVADTDKEPvmiltnlvqGRYVFTLTVSD 791
Cdd:pfam18911    1 NAAPVADAGGDRIVAEGETVT-FDASASDDpDGDILSYRWDFGDGTTATGANVSHTYAAP---------GTYTVTLTVTD 70

                           90
                   ....*....|....*
gi 24660591    792 DQGL-TSSDTVSVNV 805
Cdd:pfam18911   71 DSGAsNSTATDTVTV 85
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 700-809 1.37e-06

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 52.74  E-value: 1.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591   700 ATDTTWVKIVQER---NAAPIANAGGDHTVtLPATAIYFNGSKSWD-DLAVVKYLWTR---------DEHSLAAGVIVAD 766
Cdd:NF038112 1169 ITNTPFTSLVAEPgvcNRRPVANAGPDQTV-LERTTVTLNGSGSFDpDGDPLTYAWTQvsgpavtltGADTATPSFTAPE 1247

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 24660591   767 TDKEpvmilTNLVqgryvFTLTVSDDQGLTSSDTVSV---NVRRDP 809
Cdd:NF038112 1248 VTAD-----TVLT-----FQLVVSDGTKTSAPDTVTVlvrNVNRAP 1283
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
491-752 1.41e-06

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 51.59  E-value: 1.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591  491 TSPGNYTFKLTVTDSNNVTNSTTATIAVLKETDYAPVANAGDAVILYLPNNNVTL-------NGTASSDDHEIVAWEWTK 563
Cdd:COG3291   47 TTPGTYTVTLTVTDAAGCSDTTTKTITVGAPNPGVTTVTTSTTVTTLANTANGGAttvvagsTVGTGVATSTTTAAAPGG 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591  564 DASDEAKAVDMQNTRTPYVQLSNLEEGMYTFVLKVTDGSGQSSTAKVHVFVKPPTNSPPVAEAGSNTTTSLPINWVLLNG 643
Cdd:COG3291  127 GGGTGTTTTTGTDTGLTGSTGTASDTATVTTSVSTTDVTSDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSG 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591  644 SDSKDDIGIKSYLWKQLSGPNNAVILKSNSSIANATSLTLGLYEFELTVADENNNTATDTTWVKIVQERNAAPIANAGGD 723
Cdd:COG3291  207 TAGVTTGATSGTSGTGSATSGVAVTDVTLTGISTGDAGTPGTNTVTTSGANTAGTSTITGGTSGVVTTSAATGTSTNGTG 286

                        250       260
                 ....*....|....*....|....*....
gi 24660591  724 HTVTLPATAIYFNGSKSWDDLAVVKYLWT 752
Cdd:COG3291  287 GLGTTTAITPGNVSTTADVTGGTATLAVS 315
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 454-518 8.46e-06

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 44.75  E-value: 8.46e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24660591     454 STSTDDDKITNWHWEVISGPIGYQPvlpevnTLQLDLTSPGNYTFKLTVTDSNNvTNSTTATIAV 518
Cdd:smart00089   21 ATSSDDGSIVSYTWDFGDGTSSTGP------TVTHTYTKPGTYTVTLTVTNAVG-SASATVTVVV 78
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 716-805 1.11e-05

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 44.41  E-value: 1.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591  716 PIANAGGDHTVTLPATaIYFNGSkSWDDLAVVKYLWTRDEHSLaagvivaDTDKEPVMILTNLVQGRYVFTLTVSDDQGL 795
Cdd:cd00146    1 PTASVSAPPVAELGAS-VTFSAS-DSSGGSIVSYKWDFGDGEV-------SSSGEPTVTHTYTKPGTYTVTLTVTNAVGS 71

                         90
                 ....*....|
gi 24660591  796 TSSDTVSVNV 805
Cdd:cd00146   72 SSTKTTTVVV 81
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 454-518 2.27e-05

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 43.64  E-value: 2.27e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24660591  454 STSTDDDKITNWHWEVISGPIgyqpVLPEVNTLQLDLTSPGNYTFKLTVTDSNNVTNSTTATIAV 518
Cdd:cd00146   21 ASDSSGGSIVSYKWDFGDGEV----SSSGEPTVTHTYTKPGTYTVTLTVTNAVGSSSTKTTTVVV 81
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 527-615 4.70e-05

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 42.82  E-value: 4.70e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591     527 VANAGDAVILYLPNNNVTLNGTaSSDDHEIVAWEWTKDasdeakavDMQNTRTPYVQLSNLEEGMYTFVLKVTDGSGqSS 606
Cdd:smart00089    1 VADVSASPTVGVAGESVTFTAT-SSDDGSIVSYTWDFG--------DGTSSTGPTVTHTYTKPGTYTVTLTVTNAVG-SA 70


                    ....*....
gi 24660591     607 TAKVHVFVK 615
Cdd:smart00089   71 SATVTVVVQ 79
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 718-805 7.97e-05

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 42.05  E-value: 7.97e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591     718 ANAGGDHTVTLPATAIYFNGSkSWDDLAVVKYLWTRDEHSlaagvivadTDKEPVMILTNLVQGRYVFTLTVSDDQGlTS 797
Cdd:smart00089    2 ADVSASPTVGVAGESVTFTAT-SSDDGSIVSYTWDFGDGT---------SSTGPTVTHTYTKPGTYTVTLTVTNAVG-SA 70


                    ....*...
gi 24660591     798 SDTVSVNV 805
Cdd:smart00089   71 SATVTVVV 78
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 428-518 9.62e-05

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 41.87  E-value: 9.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591    428 NQPPQVIISPREQIirQPTTNAILDGSTSTDDD-KITNWHWE-----VISGPIG---YqpvlpevntlqldlTSPGNYTF 498
Cdd:pfam18911    1 NAAPVADAGGDRIV--AEGETVTFDASASDDPDgDILSYRWDfgdgtTATGANVshtY--------------AAPGTYTV 64

                           90       100
                   ....*....|....*....|.
gi 24660591    499 KLTVTDSNNVTNST-TATIAV 518
Cdd:pfam18911   65 TLTVTDDSGASNSTaTDTVTV 85
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
395-678 7.69e-04

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 43.12  E-value: 7.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591  395 SEGLYTFKVTVTGDNGTFGEATANVTVLPENRINQPPQVIISPREQII--RQPTTNAILDGSTSTDDDKITNWHWEVISG 472
Cdd:COG3291   48 TPGTYTVTLTVTDAAGCSDTTTKTITVGAPNPGVTTVTTSTTVTTLANtaNGGATTVVAGSTVGTGVATSTTTAAAPGGG 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591  473 PIGYQPVLPEVNTLQLDLTSPGNYTFKLTVTDSNNVTNSTTATIAVLKETDYAPVANAGDAVILYLPNNNVTLNGTASSD 552
Cdd:COG3291  128 GGTGTTTTTGTDTGLTGSTGTASDTATVTTSVSTTDVTSDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSGT 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591  553 DHEIVAWEWTKDASDEAKAVDMQNTRTPYVQLSNLEEGMYTFVLKVTDGSGQSSTAKVHVFVKPPTNSPPVAEAGSNTTT 632
Cdd:COG3291  208 AGVTTGATSGTSGTGSATSGVAVTDVTLTGISTGDAGTPGTNTVTTSGANTAGTSTITGGTSGVVTTSAATGTSTNGTGG 287

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 24660591  633 SLPINWVLLNGSDSKDDIGIKSYLWKQLSGPNNAVILKSNSSIANA 678
Cdd:COG3291  288 LGTTTAITPGNVSTTADVTGGTATLAVSSTLTTNDTTGSSSTGTVF 333
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 526-614 1.94e-03

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 38.25  E-value: 1.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591  526 PVANAGDAViLYLPNNNVTLNGTaSSDDHEIVAWEWtkDASDeaKAVDMQNTRTpyVQLSNLEEGMYTFVLKVTDGSGQS 605
Cdd:cd00146    1 PTASVSAPP-VAELGASVTFSAS-DSSGGSIVSYKW--DFGD--GEVSSSGEPT--VTHTYTKPGTYTVTLTVTNAVGSS 72


                 ....*....
gi 24660591  606 STAKVHVFV 614
Cdd:cd00146   73 STKTTTVVV 81
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
539-805 2.21e-03

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 41.58  E-value: 2.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591  539 PNNNVTLNGTASSDdheIVAWEWtkDASDEAKAvdmqNTRTPYVQLSnlEEGMYTFVLKVTDGSGQSSTAKVHVFVKPP- 617
Cdd:COG3291   10 APLTVQFTDTSSGN---ATSYEW--DFGDGTTS----TEANPSHTYT--TPGTYTVTLTVTDAAGCSDTTTKTITVGAPn 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591  618 ---TNSPPVAEAGSNTTTSLPINWVLLNGSDSKDDIGIKSYLWKQLSGPNNAVILKSNSSIANATSLTLGLYEFELTVAD 694
Cdd:COG3291   79 pgvTTVTTSTTVTTLANTANGGATTVVAGSTVGTGVATSTTTAAAPGGGGGTGTTTTTGTDTGLTGSTGTASDTATVTTS 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591  695 ENNNTATDTTWVKIVQERNAAPIANAGGDHTVTLPATAIYFNGSKSWDDLAVVKYLWTRDEHSLAAGVIVADTDKEPVMI 774
Cdd:COG3291  159 VSTTDVTSDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSGTAGVTTGATSGTSGTGSATSGVAVTDVTLTGI 238

                        250       260       270
                 ....*....|....*....|....*....|.
gi 24660591  775 LTNLVQGRYVFTLTVSDDQGLTSSDTVSVNV 805
Cdd:COG3291  239 STGDAGTPGTNTVTTSGANTAGTSTITGGTS 269
He_PIG pfam05345
Putative Ig domain; This alignment represents the conserved core region of ~90 residue repeat ...
 491-518 3.79e-03

Putative Ig domain; This alignment represents the conserved core region of ~90 residue repeat found in several haemagglutinins and other cell surface proteins. Sequence similarities to (pfam02494) and (pfam00801) suggest an Ig-like fold (personal obs:C. Yeats). So this family may be similar in function to the (pfam02639) and (pfam02638) domains. This domain is also found in the WisP family of proteins of Tropheryma whipplei.


Pssm-ID: 398814 [Multi-domain]  Cd Length: 95  Bit Score: 37.84  E-value: 3.79e-03
                           10        20
                   ....*....|....*....|....*...
gi 24660591    491 TSPGNYTFKLTVTDSNNVTNSTTATIAV 518
Cdd:pfam05345   67 VQPGTYTFTVTATDSSGLSSSTTFTLTV 94
Big_13 pfam19077
Bacterial Ig-like domain; Presumed domain found as tandem repeats of high sequence identity in ...
 502-614 4.72e-03

Bacterial Ig-like domain; Presumed domain found as tandem repeats of high sequence identity in bacterial cell surface proteins.


Pssm-ID: 465968 [Multi-domain]  Cd Length: 102  Bit Score: 37.63  E-value: 4.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591    502 VTDSNNVTNSTTATIaVLKETDyapvanaGDAVILYLPNNNVTLNGTASSDDHeiVAWEWTKDASdeakavdmqntrtpy 581
Cdd:pfam19077   17 VSDSDNITNDTTPTF-TGTNED-------GDVVTVTVSIDGNGVTGTATAGAD--GNWSFTPPAA--------------- 71

                           90       100       110
                   ....*....|....*....|....*....|...
gi 24660591    582 vqlsnLEEGMYTFVLKVTDGSGQSSTAKVHVFV 614
Cdd:pfam19077   72 -----LADGTYTLTVTVTDIAGNTATSSPLSFT 99
COG1470 COG1470
Uncharacterized membrane protein [Function unknown];
513-805 7.58e-03

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 441079 [Multi-domain]  Cd Length: 475  Bit Score: 40.23  E-value: 7.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591  513 TATIAVLKETDYAPVANAGDAVILYLPNNNVTLNGTASSDDHEIVAWEwtkdasdeakAVDMQNTRTPYVQLSNLEEGMY 592
Cdd:COG1470    1 VAAAGLVASSTVAAGALAALLDLTTPLVGSTVALTSTASALSGERTTL----------AALAATGGLVTATPVSPTSATL 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591  593 TFVLKVTDGSGQSSTAKVHVFVKPP----TNSPPVAEAGSNTTTSLPInwVLLNGSDSKDDIGIKSYL----WKQLSGPN 664
Cdd:COG1470   71 TLSVEVPSNATVGTYLPITVTVAPYgltlSVESPSLEVAPGETVTYTV--TLTNTGDEPDTVSLSAEGlpegWTVTFTPD 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591  665 NAVILKSNSS------IANATSLTLGLYEFELTV-ADENNNTATDTTWVKIVQERN-------AAPIANAGGDHTVTL-- 728
Cdd:COG1470  149 TSVSLAPGESktvtleVTPPANAEPGTYPVTVTAtSGEDSSSASLTLTLTVTGSYElelsstpTGRTVTPGESATFTVtv 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24660591  729 -------PATAIYFNGSKSwDDLAVVKYLWTRDEhsLAAG----VIVAdtdkepVMILTNLVQGRYVFTLTVSDDQGLTS 797
Cdd:COG1470  229 tntgngaDLTNVTLSASAP-SGWTVSFEPETIPS--LAPGesatVTLT------VTVPADATAGDYTVTVTATSDETASA 299


                 ....*...
gi 24660591  798 SDTVSVNV 805
Cdd:COG1470  300 TLRLTVET 307
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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