NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24660583|ref|NP_648169|]
View 

bip1, isoform A [Drosophila melanogaster]

Protein Classification

THAP domain-containing protein( domain architecture ID 10659521)

THAP domain-containing protein may act as a DNA-binding transcription regulator

CATH:  3.30.40.180|2.40.128.20
Gene Ontology:  GO:0003700|GO:0046872|GO:0043565
PubMed:  20144952|12575992
SCOP:  4002822

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 34-91 2.06e-07

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


:

Pssm-ID: 214951  Cd Length: 80  Bit Score: 48.20  E-value: 2.06e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24660583     34 CLMGCQDVKPND----LRRFPVHDTDRCNHWLRHFGVSYklVDQLGGLQKLRICSRHFSQRQ 91
Cdd:smart00980   3 CVPGCGNRSKKNpglsFFRFPKEDPELRKKWLENLGLPD--DPNRKPKKRSRICSRHFEPDD 62
 
Name Accession Description Interval E-value
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 34-91 2.06e-07

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 214951  Cd Length: 80  Bit Score: 48.20  E-value: 2.06e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24660583     34 CLMGCQDVKPND----LRRFPVHDTDRCNHWLRHFGVSYklVDQLGGLQKLRICSRHFSQRQ 91
Cdd:smart00980   3 CVPGCGNRSKKNpglsFFRFPKEDPELRKKWLENLGLPD--DPNRKPKKRSRICSRHFEPDD 62
 
Name Accession Description Interval E-value
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 34-91 2.06e-07

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 214951  Cd Length: 80  Bit Score: 48.20  E-value: 2.06e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24660583     34 CLMGCQDVKPND----LRRFPVHDTDRCNHWLRHFGVSYklVDQLGGLQKLRICSRHFSQRQ 91
Cdd:smart00980   3 CVPGCGNRSKKNpglsFFRFPKEDPELRKKWLENLGLPD--DPNRKPKKRSRICSRHFEPDD 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH