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Conserved domains on  [gi|21356747|ref|NP_648109|]
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CTCF [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
422-446 9.95e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 9.95e-05
                          10        20
                  ....*....|....*....|....*
gi 21356747   422 LKRHMVIHTGEKKYQCDICKSRFTQ 446
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
394-415 1.07e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.07e-04
                          10        20
                  ....*....|....*....|..
gi 21356747   394 LRRHMTCHTGERPYQCPHCTYA 415
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 587-609 1.61e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.61e-03
                          10        20
                  ....*....|....*....|...
gi 21356747   587 HKCPSCPREFTHKGNLMRHMETH 609
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
536-561 2.03e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.03e-03
                          10        20
                  ....*....|....*....|....*.
gi 21356747   536 HLASHMLIHLDEKPFHCDQCPQAFRQ 561
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
FAP super family cl25522
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 116-202 2.10e-03

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


The actual alignment was detected with superfamily member pfam07174:

Pssm-ID: 429334  Cd Length: 301  Bit Score: 41.06  E-value: 2.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356747   116 PGKATRSVVSTATNKSINLrPAKSTPKATTSKPPPEPKAISVRPARAAAAKAKQSAMPPPPALVVKVPAPrgrPRKNPVI 195
Cdd:pfam07174  15 WATLAIAAVAGASAVAVAL-PAVAHADPEPAPPPPSTATAPPAPPPPPPAPAAPAPPPPPAAPNAPNAPP---PPADPNA 90


                  ....*..
gi 21356747   196 PKPEPMD 202
Cdd:pfam07174  91 PPPPPAD 97
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
321-621 8.53e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 8.53e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356747 321 SFKCSICERSFRSNVGLQNHINTHMGNKPHKC--KLCESAFTTSGELVRHtRYKHTKEKPHKCTECTYASVELTKLR-RH 397
Cdd:COG5048  33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRH-LRTHHNNPSDLNSKSLPLSNSKASSSsLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356747 398 MTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDIC-KSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGR 476
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356747 477 ------------------KADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLA 538
Cdd:COG5048 192 vstsipsssensplsssySIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356747 539 SHMLIHLDE-------KPFHCDQCPQAFRQRQLLRRHMNLVhNEEYQPPEPreklHKCPS--CPREFTHKGNLMRHMETH 609
Cdd:COG5048 272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSV-NHSGESLKP----FSCPYslCGKLFSRNDALKRHILLH 346

                       330
                ....*....|..
gi 21356747 610 DDSANAREKRRR 621
Cdd:COG5048 347 TSISPAKEKLLN 358
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
422-446 9.95e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 9.95e-05
                          10        20
                  ....*....|....*....|....*
gi 21356747   422 LKRHMVIHTGEKKYQCDICKSRFTQ 446
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
394-415 1.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.07e-04
                          10        20
                  ....*....|....*....|..
gi 21356747   394 LRRHMTCHTGERPYQCPHCTYA 415
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 587-609 1.61e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.61e-03
                          10        20
                  ....*....|....*....|...
gi 21356747   587 HKCPSCPREFTHKGNLMRHMETH 609
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
536-561 2.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.03e-03
                          10        20
                  ....*....|....*....|....*.
gi 21356747   536 HLASHMLIHLDEKPFHCDQCPQAFRQ 561
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 116-202 2.10e-03

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 41.06  E-value: 2.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356747   116 PGKATRSVVSTATNKSINLrPAKSTPKATTSKPPPEPKAISVRPARAAAAKAKQSAMPPPPALVVKVPAPrgrPRKNPVI 195
Cdd:pfam07174  15 WATLAIAAVAGASAVAVAL-PAVAHADPEPAPPPPSTATAPPAPPPPPPAPAAPAPPPPPAAPNAPNAPP---PPADPNA 90


                  ....*..
gi 21356747   196 PKPEPMD 202
Cdd:pfam07174  91 PPPPPAD 97
PRK11633 PRK11633
cell division protein DedD; Provisional
 139-214 3.97e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 39.60  E-value: 3.97e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21356747  139 STPKATTSKP--PPEPKAISVRPARAAAAKAKQSAMPPPPALVVKVPAPRGRPRKNPViPKPEPMDLERELEELVDEP 214
Cdd:PRK11633  55 MMPAATQALPtqPPEGAAEAVRAGDAAAPSLDPATVAPPNTPVEPEPAPVEPPKPKPV-EKPKPKPKPQQKVEAPPAP 131
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
321-621 8.53e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 8.53e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356747 321 SFKCSICERSFRSNVGLQNHINTHMGNKPHKC--KLCESAFTTSGELVRHtRYKHTKEKPHKCTECTYASVELTKLR-RH 397
Cdd:COG5048  33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRH-LRTHHNNPSDLNSKSLPLSNSKASSSsLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356747 398 MTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDIC-KSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGR 476
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356747 477 ------------------KADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLA 538
Cdd:COG5048 192 vstsipsssensplsssySIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356747 539 SHMLIHLDE-------KPFHCDQCPQAFRQRQLLRRHMNLVhNEEYQPPEPreklHKCPS--CPREFTHKGNLMRHMETH 609
Cdd:COG5048 272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSV-NHSGESLKP----FSCPYslCGKLFSRNDALKRHILLH 346

                       330
                ....*....|..
gi 21356747 610 DDSANAREKRRR 621
Cdd:COG5048 347 TSISPAKEKLLN 358
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
422-446 9.95e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 9.95e-05
                          10        20
                  ....*....|....*....|....*
gi 21356747   422 LKRHMVIHTGEKKYQCDICKSRFTQ 446
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
394-415 1.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.07e-04
                          10        20
                  ....*....|....*....|..
gi 21356747   394 LRRHMTCHTGERPYQCPHCTYA 415
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 587-609 1.61e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.61e-03
                          10        20
                  ....*....|....*....|...
gi 21356747   587 HKCPSCPREFTHKGNLMRHMETH 609
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
536-561 2.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.03e-03
                          10        20
                  ....*....|....*....|....*.
gi 21356747   536 HLASHMLIHLDEKPFHCDQCPQAFRQ 561
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 116-202 2.10e-03

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 41.06  E-value: 2.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356747   116 PGKATRSVVSTATNKSINLrPAKSTPKATTSKPPPEPKAISVRPARAAAAKAKQSAMPPPPALVVKVPAPrgrPRKNPVI 195
Cdd:pfam07174  15 WATLAIAAVAGASAVAVAL-PAVAHADPEPAPPPPSTATAPPAPPPPPPAPAAPAPPPPPAAPNAPNAPP---PPADPNA 90


                  ....*..
gi 21356747   196 PKPEPMD 202
Cdd:pfam07174  91 PPPPPAD 97
PRK11633 PRK11633
cell division protein DedD; Provisional
 139-214 3.97e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 39.60  E-value: 3.97e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21356747  139 STPKATTSKP--PPEPKAISVRPARAAAAKAKQSAMPPPPALVVKVPAPRGRPRKNPViPKPEPMDLERELEELVDEP 214
Cdd:PRK11633  55 MMPAATQALPtqPPEGAAEAVRAGDAAAPSLDPATVAPPNTPVEPEPAPVEPPKPKPV-EKPKPKPKPQQKVEAPPAP 131
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
321-621 8.53e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 8.53e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356747 321 SFKCSICERSFRSNVGLQNHINTHMGNKPHKC--KLCESAFTTSGELVRHtRYKHTKEKPHKCTECTYASVELTKLR-RH 397
Cdd:COG5048  33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRH-LRTHHNNPSDLNSKSLPLSNSKASSSsLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356747 398 MTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDIC-KSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGR 476
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356747 477 ------------------KADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLA 538
Cdd:COG5048 192 vstsipsssensplsssySIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356747 539 SHMLIHLDE-------KPFHCDQCPQAFRQRQLLRRHMNLVhNEEYQPPEPreklHKCPS--CPREFTHKGNLMRHMETH 609
Cdd:COG5048 272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSV-NHSGESLKP----FSCPYslCGKLFSRNDALKRHILLH 346

                       330
                ....*....|..
gi 21356747 610 DDSANAREKRRR 621
Cdd:COG5048 347 TSISPAKEKLLN 358
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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