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Conserved domains on  [gi|161081372|ref|NP_647873|]
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cuticular protein 64Ab [Drosophila melanogaster]

Protein Classification

chitin-binding domain-containing protein( domain architecture ID 10448777)

chitin-binding domain-containing protein such as insect cuticle proteins, endocuticle structural proteins, and pro-resilin, which plays a central role in flight by providing low stiffness, high strain and efficient energy storage

Gene Ontology:  GO:0008061
PubMed:  11520687

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Chitin_bind_4 pfam00379
Insect cuticle protein; Many insect cuticular proteins include a 35-36 amino acid motif known ...
42-94 1.57e-15

Insect cuticle protein; Many insect cuticular proteins include a 35-36 amino acid motif known as the R_R consensus. The extensive conservation of this region led to the suggestion that it functions to bind chitin. Provocatively, it has no sequence similarity to the well-known cysteine-containing chitin-binding domain found in chitinases and some peritrophic membrane proteins. Chitin binding has been shown experimentally for this region. Thus arthropods have two distinct classes of chitin binding proteins, those with the chitin-binding domain found in lectins, chitinases and peritrophic membranes (cysCBD) and those with the cuticular protein chitin-binding domain (non-cysCBD).


:

Pssm-ID: 459790 [Multi-domain]  Cd Length: 52  Bit Score: 65.36  E-value: 1.57e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 161081372   42 YAFAYNVQDaltgDSKSQQEVR----DGDVVKGSYSVVDADGSLRTVFYTADpINGF 94
Cdd:pfam00379   1 YSFSYETSD----GISRQEEGRgtddEGGVVQGSYSYVDPDGQTRTVNYTAD-ENGF 52
 
Name Accession Description Interval E-value
Chitin_bind_4 pfam00379
Insect cuticle protein; Many insect cuticular proteins include a 35-36 amino acid motif known ...
42-94 1.57e-15

Insect cuticle protein; Many insect cuticular proteins include a 35-36 amino acid motif known as the R_R consensus. The extensive conservation of this region led to the suggestion that it functions to bind chitin. Provocatively, it has no sequence similarity to the well-known cysteine-containing chitin-binding domain found in chitinases and some peritrophic membrane proteins. Chitin binding has been shown experimentally for this region. Thus arthropods have two distinct classes of chitin binding proteins, those with the chitin-binding domain found in lectins, chitinases and peritrophic membranes (cysCBD) and those with the cuticular protein chitin-binding domain (non-cysCBD).


Pssm-ID: 459790 [Multi-domain]  Cd Length: 52  Bit Score: 65.36  E-value: 1.57e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 161081372   42 YAFAYNVQDaltgDSKSQQEVR----DGDVVKGSYSVVDADGSLRTVFYTADpINGF 94
Cdd:pfam00379   1 YSFSYETSD----GISRQEEGRgtddEGGVVQGSYSYVDPDGQTRTVNYTAD-ENGF 52
 
Name Accession Description Interval E-value
Chitin_bind_4 pfam00379
Insect cuticle protein; Many insect cuticular proteins include a 35-36 amino acid motif known ...
42-94 1.57e-15

Insect cuticle protein; Many insect cuticular proteins include a 35-36 amino acid motif known as the R_R consensus. The extensive conservation of this region led to the suggestion that it functions to bind chitin. Provocatively, it has no sequence similarity to the well-known cysteine-containing chitin-binding domain found in chitinases and some peritrophic membrane proteins. Chitin binding has been shown experimentally for this region. Thus arthropods have two distinct classes of chitin binding proteins, those with the chitin-binding domain found in lectins, chitinases and peritrophic membranes (cysCBD) and those with the cuticular protein chitin-binding domain (non-cysCBD).


Pssm-ID: 459790 [Multi-domain]  Cd Length: 52  Bit Score: 65.36  E-value: 1.57e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 161081372   42 YAFAYNVQDaltgDSKSQQEVR----DGDVVKGSYSVVDADGSLRTVFYTADpINGF 94
Cdd:pfam00379   1 YSFSYETSD----GISRQEEGRgtddEGGVVQGSYSYVDPDGQTRTVNYTAD-ENGF 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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