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Conserved domains on  [gi|21245088|ref|NP_640350|]
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lymphocyte antigen 6B precursor [Rattus norvegicus]

Protein Classification

Ly-6/uPAR domain-containing protein( domain architecture ID 10061478)

LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_Ly6A_like cd23541
extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; ...
 25-107 2.39e-31

extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; The family includes mouse Ly-6 lymphocyte antigens, such as Ly-6A/Ly-6E, Ly-6B, Ly-6C1/6C2, Ly-6F, and Ly-6I/Ly-6M. Ly-6A/Ly-6E (also called stem cell antigen 1/SCA-1, or T-cell-activating protein/TAP) and Ly-6C are involved in T-cell activation. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467071  Cd Length: 83  Bit Score: 106.65  E-value: 2.39e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245088  25 QGLNCYNCTMIPFGNTCSStATCPYPDGVCTIQVAEVVVSSVRLKVKSNLCLPGCPK-SPQTPEVLGTVVHVNTDCCNTD 103
Cdd:cd23541   1 QGLRCYQCLGVPLETSCPS-VTCSYPDGVCVSQEVETIVGSQRVKLKNKFCLPFCPKnLYFLEEILGTTVNVKTSCCKED 79


                ....
gi 21245088 104 LCNA 107
Cdd:cd23541  80 LCNA 83
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6A_like cd23541
extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; ...
 25-107 2.39e-31

extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; The family includes mouse Ly-6 lymphocyte antigens, such as Ly-6A/Ly-6E, Ly-6B, Ly-6C1/6C2, Ly-6F, and Ly-6I/Ly-6M. Ly-6A/Ly-6E (also called stem cell antigen 1/SCA-1, or T-cell-activating protein/TAP) and Ly-6C are involved in T-cell activation. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467071  Cd Length: 83  Bit Score: 106.65  E-value: 2.39e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245088  25 QGLNCYNCTMIPFGNTCSStATCPYPDGVCTIQVAEVVVSSVRLKVKSNLCLPGCPK-SPQTPEVLGTVVHVNTDCCNTD 103
Cdd:cd23541   1 QGLRCYQCLGVPLETSCPS-VTCSYPDGVCVSQEVETIVGSQRVKLKNKFCLPFCPKnLYFLEEILGTTVNVKTSCCKED 79


                ....
gi 21245088 104 LCNA 107
Cdd:cd23541  80 LCNA 83
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 27-112 1.95e-15

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 66.40  E-value: 1.95e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245088     27 LNCYNCTMIPfGNTCSSTATCPYPDGVCTIQVAEVVV-SSVRLKVKSNLCLPGCPKSPQTpEVLGTVVHVNTDCCNTDLC 105
Cdd:smart00134   1 LQCYSCTGNP-DSSCSSEEECRSPDDVCLTVVAEVISdSRGSVVYKGCATSPICPGSHGY-EINLTIAFLKVSCCQTDLC 78


                   ....*..
gi 21245088    106 NAAGPTG 112
Cdd:smart00134  79 NAAGPGA 85
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 29-106 2.24e-12

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 58.32  E-value: 2.24e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21245088    29 CYNCTMIPFGNtCSSTATCPYPDGVCTIQVAEVVVSSVRLKVKSNLCL-PGCPKSPQTpEVLGTVVHVNTDCCNTDLCN 106
Cdd:pfam00021   1 CYSCLGVSNED-CLSEVTCPLSDGQCVTTTLELPEGNLRGTVVSKGCArSSCPRLLSD-FINGGIISVSESCCQSDLCN 77
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6A_like cd23541
extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; ...
 25-107 2.39e-31

extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; The family includes mouse Ly-6 lymphocyte antigens, such as Ly-6A/Ly-6E, Ly-6B, Ly-6C1/6C2, Ly-6F, and Ly-6I/Ly-6M. Ly-6A/Ly-6E (also called stem cell antigen 1/SCA-1, or T-cell-activating protein/TAP) and Ly-6C are involved in T-cell activation. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467071  Cd Length: 83  Bit Score: 106.65  E-value: 2.39e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245088  25 QGLNCYNCTMIPFGNTCSStATCPYPDGVCTIQVAEVVVSSVRLKVKSNLCLPGCPK-SPQTPEVLGTVVHVNTDCCNTD 103
Cdd:cd23541   1 QGLRCYQCLGVPLETSCPS-VTCSYPDGVCVSQEVETIVGSQRVKLKNKFCLPFCPKnLYFLEEILGTTVNVKTSCCKED 79


                ....
gi 21245088 104 LCNA 107
Cdd:cd23541  80 LCNA 83
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 27-112 1.95e-15

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 66.40  E-value: 1.95e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245088     27 LNCYNCTMIPfGNTCSSTATCPYPDGVCTIQVAEVVV-SSVRLKVKSNLCLPGCPKSPQTpEVLGTVVHVNTDCCNTDLC 105
Cdd:smart00134   1 LQCYSCTGNP-DSSCSSEEECRSPDDVCLTVVAEVISdSRGSVVYKGCATSPICPGSHGY-EINLTIAFLKVSCCQTDLC 78


                   ....*..
gi 21245088    106 NAAGPTG 112
Cdd:smart00134  79 NAAGPGA 85
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 29-106 2.24e-12

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 58.32  E-value: 2.24e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21245088    29 CYNCTMIPFGNtCSSTATCPYPDGVCTIQVAEVVVSSVRLKVKSNLCL-PGCPKSPQTpEVLGTVVHVNTDCCNTDLCN 106
Cdd:pfam00021   1 CYSCLGVSNED-CLSEVTCPLSDGQCVTTTLELPEGNLRGTVVSKGCArSSCPRLLSD-FINGGIISVSESCCQSDLCN 77
TFP_LU_ECD_GPIHBP1 cd23575
extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density ...
 27-111 3.98e-05

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467105  Cd Length: 83  Bit Score: 39.62  E-value: 3.98e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245088  27 LNCYNCTMIPFGNTCSSTATCPYPDGVCTIQVAEVVVSSVRLKVKSNLCLPGCPKSPQTPEvlgtVVHVNTDCCNTDLCN 106
Cdd:cd23575   3 LKCYTCVSAHSNSDCLTETNCSSSDTYCKTLVASASGGSGSLTTITKWCASSCTPSTRTVE----GTKVTVSCCQTDLCN 78


                ....*
gi 21245088 107 AAGPT 111
Cdd:cd23575  79 VSGAQ 83
TFP_LU_ECD_SLURP2 cd23561
extracellular domain (ECD) found in Secreted Ly-6/uPAR-related protein 2 (SLURP-2) and similar ...
 27-106 5.31e-03

extracellular domain (ECD) found in Secreted Ly-6/uPAR-related protein 2 (SLURP-2) and similar proteins; SLURP-2 (also called Lynx1, or secreted Ly-6/uPAR domain-containing protein 2, or secreted LY6/PLAUR domain-containing protein 2) binds and may modulate the functional properties of nicotinic and muscarinic acetylcholine receptors. It may regulate keratinocytes proliferation, differentiation, and apoptosis. In vitro SLURP-2 moderately inhibits ACh-evoked currents of alpha-3:beta-2-containing nAChRs and strongly inhibits alpha-4:beta-2-containing nAChRs, modulates alpha-7-containing nAChRs, and inhibits nicotine-induced signaling probably implicating alpha-3:beta-4-containing nAChRs. It may act on alpha-3:beta-2 and alpha-7 nAChRs in an orthosteric, and on mAChRs, such as CHRM1 and CHRM3, in an allosteric manner. SLURP-2 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467091  Cd Length: 75  Bit Score: 33.77  E-value: 5.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245088  27 LNCYNCTmiPFGNtCSSTATCPYPDGVCTIQVAEVVVSSVRLKVKSNLCLPGCPKSPQtpevLGTVVHVNTDCCNTDLCN 106
Cdd:cd23561   1 IWCHQCT--GFGG-CSHGSRCPRDSTHCVTTATRVLSNTEDLPLVTKMCHIGCPDIPS----LGLGPYVSIACCQTSLCN 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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