chloride channel accessory 3B precursor [Mus musculus]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||||||||
| hCaCC super family | cl31034 | calcium-activated chloride channel protein 1; found a row in 1A13.INFO that was not parsed out ... |
1-869 | 0e+00 | ||||||||||||
calcium-activated chloride channel protein 1; found a row in 1A13.INFO that was not parsed out AC found a row in 1A13.INFO that was not parsed out EC found a row in 1A13.INFO that was not parsed out GA found a row in 1A13.INFO that was not parsed out SO found a row in 1A13.INFO that was not parsed out RH found a row in 1A13.INFO that was not parsed out EN found a row in 1A13.INFO that was not parsed out GS found a row in 1A13.INFO that was not parsed out AL found a row in 1A13.INFO that was not parsed out The Epithelial Chloride Channel (E-ClC) Family (TC 1.A.13) found a row in 1A13.INFO that was not parsed out found a row in 1A13.INFO that was not parsed out Mammals have multiple isoforms of epithelial chloride channel proteins. The first member of this family to be characterized was a respiratory epithelium, Ca found a row in 1A13.INFO that was not parsed out 2+-regulated, chloride channel protein isolated from bovine tracheal apical membranes. It was biochemically characterized as a 140 kDa complex. The purified found a row in 1A13.INFO that was not parsed out complex when reconstituted in a planar lipid bilayer behaved as an anion-selective channel. It was regulated by Ca 2+ via a calmodulin kinase II-dependent found a row in 1A13.INFO that was not parsed out mechanism. When the cRNA was injected into Xenopus oocytes, an outward rectifying, DIDS-sensitive, anion conductance was measured. A related gene, found a row in 1A13.INFO that was not parsed out Lu-ECAM, was cloned from the bovine aortic endothelial cell line, BAEC. It is expressed in the lung and spleen but not in the trachea. Homologues are found in found a row in 1A13.INFO that was not parsed out several mammals, and at least three paralogues(hCaCC-1-3) are present in humans, each with different tissue distributions. found a row in 1A13.INFO that was not parsed out [Transport and binding proteins, Anions] The actual alignment was detected with superfamily member TIGR00868: Pssm-ID: 129946 [Multi-domain] Cd Length: 863 Bit Score: 1479.36 E-value: 0e+00
|
||||||||||||||||
| PHA03247 super family | cl33720 | large tegument protein UL36; Provisional |
875-1022 | 2.80e-17 | ||||||||||||
large tegument protein UL36; Provisional The actual alignment was detected with superfamily member PHA03247: Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 88.07 E-value: 2.80e-17
|
||||||||||||||||
| Name | Accession | Description | Interval | E-value | ||||||||||||
| hCaCC | TIGR00868 | calcium-activated chloride channel protein 1; found a row in 1A13.INFO that was not parsed out ... |
1-869 | 0e+00 | ||||||||||||
calcium-activated chloride channel protein 1; found a row in 1A13.INFO that was not parsed out AC found a row in 1A13.INFO that was not parsed out EC found a row in 1A13.INFO that was not parsed out GA found a row in 1A13.INFO that was not parsed out SO found a row in 1A13.INFO that was not parsed out RH found a row in 1A13.INFO that was not parsed out EN found a row in 1A13.INFO that was not parsed out GS found a row in 1A13.INFO that was not parsed out AL found a row in 1A13.INFO that was not parsed out The Epithelial Chloride Channel (E-ClC) Family (TC 1.A.13) found a row in 1A13.INFO that was not parsed out found a row in 1A13.INFO that was not parsed out Mammals have multiple isoforms of epithelial chloride channel proteins. The first member of this family to be characterized was a respiratory epithelium, Ca found a row in 1A13.INFO that was not parsed out 2+-regulated, chloride channel protein isolated from bovine tracheal apical membranes. It was biochemically characterized as a 140 kDa complex. The purified found a row in 1A13.INFO that was not parsed out complex when reconstituted in a planar lipid bilayer behaved as an anion-selective channel. It was regulated by Ca 2+ via a calmodulin kinase II-dependent found a row in 1A13.INFO that was not parsed out mechanism. When the cRNA was injected into Xenopus oocytes, an outward rectifying, DIDS-sensitive, anion conductance was measured. A related gene, found a row in 1A13.INFO that was not parsed out Lu-ECAM, was cloned from the bovine aortic endothelial cell line, BAEC. It is expressed in the lung and spleen but not in the trachea. Homologues are found in found a row in 1A13.INFO that was not parsed out several mammals, and at least three paralogues(hCaCC-1-3) are present in humans, each with different tissue distributions. found a row in 1A13.INFO that was not parsed out [Transport and binding proteins, Anions] Pssm-ID: 129946 [Multi-domain] Cd Length: 863 Bit Score: 1479.36 E-value: 0e+00
|
||||||||||||||||
| CLCA | pfam08434 | Calcium-activated chloride channel N terminal; The CLCA family of calcium-activated chloride ... |
24-289 | 0e+00 | ||||||||||||
Calcium-activated chloride channel N terminal; The CLCA family of calcium-activated chloride channels has been identified in many epithelial and endothelial cell types as well as in smooth muscle cells and has four or five putative transmembrane regions. Additionally to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumour suppressors. This protein cleaves itself into an N-terminal portion and a C-terminal portion. The N-terminus contains an HEXXHXXXGXXDE motif which is essential for proteolytic cleavage. Pssm-ID: 462476 Cd Length: 266 Bit Score: 551.16 E-value: 0e+00
|
||||||||||||||||
| vWFA | cd00198 | Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ... |
307-464 | 9.76e-25 | ||||||||||||
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Pssm-ID: 238119 [Multi-domain] Cd Length: 161 Bit Score: 101.49 E-value: 9.76e-25
|
||||||||||||||||
| ChlD | COG1240 | vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ... |
285-476 | 2.04e-21 | ||||||||||||
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism]; Pssm-ID: 440853 [Multi-domain] Cd Length: 262 Bit Score: 95.01 E-value: 2.04e-21
|
||||||||||||||||
| VWA | smart00327 | von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ... |
309-474 | 1.24e-19 | ||||||||||||
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods. Pssm-ID: 214621 [Multi-domain] Cd Length: 175 Bit Score: 87.51 E-value: 1.24e-19
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
875-1022 | 2.80e-17 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 88.07 E-value: 2.80e-17
|
||||||||||||||||
| SPT5 | COG5164 | Transcription elongation factor SPT5 [Transcription]; |
883-1030 | 1.44e-13 | ||||||||||||
Transcription elongation factor SPT5 [Transcription]; Pssm-ID: 444063 [Multi-domain] Cd Length: 495 Bit Score: 74.68 E-value: 1.44e-13
|
||||||||||||||||
| Hamartin | pfam04388 | Hamartin protein; This family includes the hamartin protein which is thought to function as a ... |
875-1021 | 1.52e-13 | ||||||||||||
Hamartin protein; This family includes the hamartin protein which is thought to function as a tumour suppressor. The hamartin protein interacts with the tuberin protein pfam03542. Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is characterized by the presence of hamartomas in many organs, such as brain, skin, heart, lung, and kidney. It is caused by mutation either TSC1 or TSC2 tumour suppressor gene. TSC1 encodes a protein, hamartin, containing two coiled-coil regions, which have been shown to mediate binding to tuberin. The TSC2 gene codes for tuberin pfam03542. These two proteins function within the same pathway(s) regulating cell cycle, cell growth, adhesion, and vesicular trafficking. Pssm-ID: 461287 [Multi-domain] Cd Length: 730 Bit Score: 75.09 E-value: 1.52e-13
|
||||||||||||||||
| gly_rich_SclB | NF038329 | LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ... |
885-1022 | 3.53e-09 | ||||||||||||
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats. Pssm-ID: 468478 [Multi-domain] Cd Length: 440 Bit Score: 60.30 E-value: 3.53e-09
|
||||||||||||||||
| gly_rich_SclB | NF038329 | LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ... |
882-1026 | 1.37e-08 | ||||||||||||
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats. Pssm-ID: 468478 [Multi-domain] Cd Length: 440 Bit Score: 58.38 E-value: 1.37e-08
|
||||||||||||||||
| gly_rich_SclB | NF038329 | LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ... |
912-1025 | 5.66e-08 | ||||||||||||
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats. Pssm-ID: 468478 [Multi-domain] Cd Length: 440 Bit Score: 56.45 E-value: 5.66e-08
|
||||||||||||||||
| KLF3_N | cd21577 | N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called ... |
883-1003 | 2.88e-06 | ||||||||||||
N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called Krueppel-like factor 3 and originally called Basic Kruppel-like Factor/BKLF), was the third member of the KLF family of zinc finger transcription factors to be discovered. KLF3 possesses a wide range of biological impacts on regulating apoptosis, differentiation, and proliferation in various tissues during the entire progression process. It has been proposed as a tumor suppressor in colorectal cancer. It appears to function predominantly as a repressor of transcription, turning genes off by recruiting the C-terminal Binding Protein co-repressors CtBP1 and CtBP2. CtBP docks onto a short motif (residues 61-65) in the N-terminus of KLF3, through the Proline-X-Aspartate-Leucine-Serine (PXDLS) motif. CtBP in turn recruits histone modifying enzymes to alter chromatin and repress gene expression. KLF3 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF3. Pssm-ID: 410554 [Multi-domain] Cd Length: 214 Bit Score: 49.27 E-value: 2.88e-06
|
||||||||||||||||
| Streccoc_I_II | NF033804 | antigen I/II family LPXTG-anchored adhesin; Members of the antigen I/II family are adhesins ... |
797-1025 | 3.27e-06 | ||||||||||||
antigen I/II family LPXTG-anchored adhesin; Members of the antigen I/II family are adhesins with a glucan-binding domain, two types of repetitive regions, an isopeptide bond-forming domain associated with shear resistance, and a C-terminal LPXTG motif for anchoring to the cell wall. They occur in oral Streptococci, and tend to be major cell surface adhesins. Members of this family include SspA and SspB from Streptococcus gordonii, antigen I/II from S. mutans, etc. Pssm-ID: 468188 [Multi-domain] Cd Length: 1552 Bit Score: 51.48 E-value: 3.27e-06
|
||||||||||||||||
| half-pint | TIGR01645 | poly-U binding splicing factor, half-pint family; The proteins represented by this model ... |
843-1002 | 8.30e-06 | ||||||||||||
poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA. Pssm-ID: 130706 [Multi-domain] Cd Length: 612 Bit Score: 49.68 E-value: 8.30e-06
|
||||||||||||||||
| PspC_subgroup_2 | NF033839 | pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ... |
880-1017 | 1.29e-05 | ||||||||||||
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. Pssm-ID: 468202 [Multi-domain] Cd Length: 557 Bit Score: 49.00 E-value: 1.29e-05
|
||||||||||||||||
| PspC_subgroup_2 | NF033839 | pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ... |
715-1017 | 1.17e-03 | ||||||||||||
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. Pssm-ID: 468202 [Multi-domain] Cd Length: 557 Bit Score: 42.83 E-value: 1.17e-03
|
||||||||||||||||
| SAV_2336_NTERM | NF041121 | SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ... |
945-1031 | 2.71e-03 | ||||||||||||
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems. Pssm-ID: 469044 [Multi-domain] Cd Length: 473 Bit Score: 41.53 E-value: 2.71e-03
|
||||||||||||||||
| SAV_2336_NTERM | NF041121 | SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ... |
927-1014 | 6.56e-03 | ||||||||||||
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems. Pssm-ID: 469044 [Multi-domain] Cd Length: 473 Bit Score: 40.37 E-value: 6.56e-03
|
||||||||||||||||
| SAV_2336_NTERM | NF041121 | SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ... |
918-1005 | 6.56e-03 | ||||||||||||
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems. Pssm-ID: 469044 [Multi-domain] Cd Length: 473 Bit Score: 40.37 E-value: 6.56e-03
|
||||||||||||||||
| SAV_2336_NTERM | NF041121 | SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ... |
909-996 | 6.56e-03 | ||||||||||||
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems. Pssm-ID: 469044 [Multi-domain] Cd Length: 473 Bit Score: 40.37 E-value: 6.56e-03
|
||||||||||||||||
| SAV_2336_NTERM | NF041121 | SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ... |
900-987 | 6.56e-03 | ||||||||||||
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems. Pssm-ID: 469044 [Multi-domain] Cd Length: 473 Bit Score: 40.37 E-value: 6.56e-03
|
||||||||||||||||
| SAV_2336_NTERM | NF041121 | SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ... |
891-978 | 6.56e-03 | ||||||||||||
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems. Pssm-ID: 469044 [Multi-domain] Cd Length: 473 Bit Score: 40.37 E-value: 6.56e-03
|
||||||||||||||||
| SAV_2336_NTERM | NF041121 | SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ... |
936-1023 | 6.56e-03 | ||||||||||||
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems. Pssm-ID: 469044 [Multi-domain] Cd Length: 473 Bit Score: 40.37 E-value: 6.56e-03
|
||||||||||||||||
| Name | Accession | Description | Interval | E-value | ||||||||||||
| hCaCC | TIGR00868 | calcium-activated chloride channel protein 1; found a row in 1A13.INFO that was not parsed out ... |
1-869 | 0e+00 | ||||||||||||
calcium-activated chloride channel protein 1; found a row in 1A13.INFO that was not parsed out AC found a row in 1A13.INFO that was not parsed out EC found a row in 1A13.INFO that was not parsed out GA found a row in 1A13.INFO that was not parsed out SO found a row in 1A13.INFO that was not parsed out RH found a row in 1A13.INFO that was not parsed out EN found a row in 1A13.INFO that was not parsed out GS found a row in 1A13.INFO that was not parsed out AL found a row in 1A13.INFO that was not parsed out The Epithelial Chloride Channel (E-ClC) Family (TC 1.A.13) found a row in 1A13.INFO that was not parsed out found a row in 1A13.INFO that was not parsed out Mammals have multiple isoforms of epithelial chloride channel proteins. The first member of this family to be characterized was a respiratory epithelium, Ca found a row in 1A13.INFO that was not parsed out 2+-regulated, chloride channel protein isolated from bovine tracheal apical membranes. It was biochemically characterized as a 140 kDa complex. The purified found a row in 1A13.INFO that was not parsed out complex when reconstituted in a planar lipid bilayer behaved as an anion-selective channel. It was regulated by Ca 2+ via a calmodulin kinase II-dependent found a row in 1A13.INFO that was not parsed out mechanism. When the cRNA was injected into Xenopus oocytes, an outward rectifying, DIDS-sensitive, anion conductance was measured. A related gene, found a row in 1A13.INFO that was not parsed out Lu-ECAM, was cloned from the bovine aortic endothelial cell line, BAEC. It is expressed in the lung and spleen but not in the trachea. Homologues are found in found a row in 1A13.INFO that was not parsed out several mammals, and at least three paralogues(hCaCC-1-3) are present in humans, each with different tissue distributions. found a row in 1A13.INFO that was not parsed out [Transport and binding proteins, Anions] Pssm-ID: 129946 [Multi-domain] Cd Length: 863 Bit Score: 1479.36 E-value: 0e+00
|
||||||||||||||||
| CLCA | pfam08434 | Calcium-activated chloride channel N terminal; The CLCA family of calcium-activated chloride ... |
24-289 | 0e+00 | ||||||||||||
Calcium-activated chloride channel N terminal; The CLCA family of calcium-activated chloride channels has been identified in many epithelial and endothelial cell types as well as in smooth muscle cells and has four or five putative transmembrane regions. Additionally to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumour suppressors. This protein cleaves itself into an N-terminal portion and a C-terminal portion. The N-terminus contains an HEXXHXXXGXXDE motif which is essential for proteolytic cleavage. Pssm-ID: 462476 Cd Length: 266 Bit Score: 551.16 E-value: 0e+00
|
||||||||||||||||
| vWFA | cd00198 | Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ... |
307-464 | 9.76e-25 | ||||||||||||
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Pssm-ID: 238119 [Multi-domain] Cd Length: 161 Bit Score: 101.49 E-value: 9.76e-25
|
||||||||||||||||
| ChlD | COG1240 | vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ... |
285-476 | 2.04e-21 | ||||||||||||
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism]; Pssm-ID: 440853 [Multi-domain] Cd Length: 262 Bit Score: 95.01 E-value: 2.04e-21
|
||||||||||||||||
| VWA | smart00327 | von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ... |
309-474 | 1.24e-19 | ||||||||||||
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods. Pssm-ID: 214621 [Multi-domain] Cd Length: 175 Bit Score: 87.51 E-value: 1.24e-19
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
875-1022 | 2.80e-17 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 88.07 E-value: 2.80e-17
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
868-1021 | 7.63e-16 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 83.06 E-value: 7.63e-16
|
||||||||||||||||
| YfbK | COG2304 | Secreted protein containing bacterial Ig-like domain and vWFA domain [General function ... |
309-464 | 1.08e-14 | ||||||||||||
Secreted protein containing bacterial Ig-like domain and vWFA domain [General function prediction only]; Pssm-ID: 441879 [Multi-domain] Cd Length: 289 Bit Score: 75.91 E-value: 1.08e-14
|
||||||||||||||||
| ViaA | COG2425 | Uncharacterized conserved protein, contains a von Willebrand factor type A (vWA) domain ... |
289-456 | 2.37e-14 | ||||||||||||
Uncharacterized conserved protein, contains a von Willebrand factor type A (vWA) domain [Function unknown]; Pssm-ID: 441973 [Multi-domain] Cd Length: 263 Bit Score: 74.33 E-value: 2.37e-14
|
||||||||||||||||
| SPT5 | COG5164 | Transcription elongation factor SPT5 [Transcription]; |
883-1030 | 1.44e-13 | ||||||||||||
Transcription elongation factor SPT5 [Transcription]; Pssm-ID: 444063 [Multi-domain] Cd Length: 495 Bit Score: 74.68 E-value: 1.44e-13
|
||||||||||||||||
| TerY | COG4245 | Uncharacterized conserved protein YegL, contains vWA domain of TerY type [Function unknown]; |
309-476 | 1.47e-13 | ||||||||||||
Uncharacterized conserved protein YegL, contains vWA domain of TerY type [Function unknown]; Pssm-ID: 443387 [Multi-domain] Cd Length: 196 Bit Score: 70.34 E-value: 1.47e-13
|
||||||||||||||||
| Hamartin | pfam04388 | Hamartin protein; This family includes the hamartin protein which is thought to function as a ... |
875-1021 | 1.52e-13 | ||||||||||||
Hamartin protein; This family includes the hamartin protein which is thought to function as a tumour suppressor. The hamartin protein interacts with the tuberin protein pfam03542. Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is characterized by the presence of hamartomas in many organs, such as brain, skin, heart, lung, and kidney. It is caused by mutation either TSC1 or TSC2 tumour suppressor gene. TSC1 encodes a protein, hamartin, containing two coiled-coil regions, which have been shown to mediate binding to tuberin. The TSC2 gene codes for tuberin pfam03542. These two proteins function within the same pathway(s) regulating cell cycle, cell growth, adhesion, and vesicular trafficking. Pssm-ID: 461287 [Multi-domain] Cd Length: 730 Bit Score: 75.09 E-value: 1.52e-13
|
||||||||||||||||
| SPT5 | COG5164 | Transcription elongation factor SPT5 [Transcription]; |
883-1030 | 1.89e-13 | ||||||||||||
Transcription elongation factor SPT5 [Transcription]; Pssm-ID: 444063 [Multi-domain] Cd Length: 495 Bit Score: 74.30 E-value: 1.89e-13
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
874-1021 | 3.05e-13 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 74.59 E-value: 3.05e-13
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
875-1025 | 3.10e-13 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 74.59 E-value: 3.10e-13
|
||||||||||||||||
| SPT5 | COG5164 | Transcription elongation factor SPT5 [Transcription]; |
883-1026 | 5.14e-13 | ||||||||||||
Transcription elongation factor SPT5 [Transcription]; Pssm-ID: 444063 [Multi-domain] Cd Length: 495 Bit Score: 72.76 E-value: 5.14e-13
|
||||||||||||||||
| SPT5 | COG5164 | Transcription elongation factor SPT5 [Transcription]; |
881-1030 | 6.97e-13 | ||||||||||||
Transcription elongation factor SPT5 [Transcription]; Pssm-ID: 444063 [Multi-domain] Cd Length: 495 Bit Score: 72.37 E-value: 6.97e-13
|
||||||||||||||||
| SPT5 | COG5164 | Transcription elongation factor SPT5 [Transcription]; |
881-1025 | 7.95e-13 | ||||||||||||
Transcription elongation factor SPT5 [Transcription]; Pssm-ID: 444063 [Multi-domain] Cd Length: 495 Bit Score: 71.98 E-value: 7.95e-13
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
861-1021 | 8.25e-13 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 73.43 E-value: 8.25e-13
|
||||||||||||||||
| SPT5 | COG5164 | Transcription elongation factor SPT5 [Transcription]; |
883-1025 | 1.23e-12 | ||||||||||||
Transcription elongation factor SPT5 [Transcription]; Pssm-ID: 444063 [Multi-domain] Cd Length: 495 Bit Score: 71.60 E-value: 1.23e-12
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
875-1034 | 1.45e-12 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 72.28 E-value: 1.45e-12
|
||||||||||||||||
| SPT5 | COG5164 | Transcription elongation factor SPT5 [Transcription]; |
883-1030 | 2.11e-12 | ||||||||||||
Transcription elongation factor SPT5 [Transcription]; Pssm-ID: 444063 [Multi-domain] Cd Length: 495 Bit Score: 70.83 E-value: 2.11e-12
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
875-1021 | 2.45e-12 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 71.89 E-value: 2.45e-12
|
||||||||||||||||
| Hamartin | pfam04388 | Hamartin protein; This family includes the hamartin protein which is thought to function as a ... |
883-1021 | 2.88e-12 | ||||||||||||
Hamartin protein; This family includes the hamartin protein which is thought to function as a tumour suppressor. The hamartin protein interacts with the tuberin protein pfam03542. Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is characterized by the presence of hamartomas in many organs, such as brain, skin, heart, lung, and kidney. It is caused by mutation either TSC1 or TSC2 tumour suppressor gene. TSC1 encodes a protein, hamartin, containing two coiled-coil regions, which have been shown to mediate binding to tuberin. The TSC2 gene codes for tuberin pfam03542. These two proteins function within the same pathway(s) regulating cell cycle, cell growth, adhesion, and vesicular trafficking. Pssm-ID: 461287 [Multi-domain] Cd Length: 730 Bit Score: 70.86 E-value: 2.88e-12
|
||||||||||||||||
| SPT5 | COG5164 | Transcription elongation factor SPT5 [Transcription]; |
875-1021 | 3.14e-12 | ||||||||||||
Transcription elongation factor SPT5 [Transcription]; Pssm-ID: 444063 [Multi-domain] Cd Length: 495 Bit Score: 70.06 E-value: 3.14e-12
|
||||||||||||||||
| VWA | pfam00092 | von Willebrand factor type A domain; |
309-476 | 3.41e-12 | ||||||||||||
von Willebrand factor type A domain; Pssm-ID: 459670 [Multi-domain] Cd Length: 174 Bit Score: 65.76 E-value: 3.41e-12
|
||||||||||||||||
| SPT5 | COG5164 | Transcription elongation factor SPT5 [Transcription]; |
883-1031 | 3.49e-12 | ||||||||||||
Transcription elongation factor SPT5 [Transcription]; Pssm-ID: 444063 [Multi-domain] Cd Length: 495 Bit Score: 70.06 E-value: 3.49e-12
|
||||||||||||||||
| Atrophin-1 | pfam03154 | Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
855-1021 | 3.92e-12 | ||||||||||||
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity. Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 70.57 E-value: 3.92e-12
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
881-1038 | 5.03e-12 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 70.74 E-value: 5.03e-12
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
882-1034 | 6.64e-12 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 70.35 E-value: 6.64e-12
|
||||||||||||||||
| Atrophin-1 | pfam03154 | Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
875-1018 | 1.12e-11 | ||||||||||||
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity. Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 69.03 E-value: 1.12e-11
|
||||||||||||||||
| Atrophin-1 | pfam03154 | Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
876-1031 | 1.12e-11 | ||||||||||||
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity. Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 69.03 E-value: 1.12e-11
|
||||||||||||||||
| SPT5 | COG5164 | Transcription elongation factor SPT5 [Transcription]; |
881-1027 | 1.50e-11 | ||||||||||||
Transcription elongation factor SPT5 [Transcription]; Pssm-ID: 444063 [Multi-domain] Cd Length: 495 Bit Score: 68.13 E-value: 1.50e-11
|
||||||||||||||||
| SPT5 | COG5164 | Transcription elongation factor SPT5 [Transcription]; |
883-1023 | 2.00e-11 | ||||||||||||
Transcription elongation factor SPT5 [Transcription]; Pssm-ID: 444063 [Multi-domain] Cd Length: 495 Bit Score: 67.75 E-value: 2.00e-11
|
||||||||||||||||
| PHA03307 | PHA03307 | transcriptional regulator ICP4; Provisional |
885-1031 | 2.79e-11 | ||||||||||||
transcriptional regulator ICP4; Provisional Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 67.89 E-value: 2.79e-11
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
882-1032 | 3.63e-11 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 68.04 E-value: 3.63e-11
|
||||||||||||||||
| PHA03307 | PHA03307 | transcriptional regulator ICP4; Provisional |
875-1021 | 4.12e-11 | ||||||||||||
transcriptional regulator ICP4; Provisional Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 67.50 E-value: 4.12e-11
|
||||||||||||||||
| Chi1 | COG3469 | Chitinase [Carbohydrate transport and metabolism]; |
881-1027 | 9.70e-11 | ||||||||||||
Chitinase [Carbohydrate transport and metabolism]; Pssm-ID: 442692 [Multi-domain] Cd Length: 534 Bit Score: 65.54 E-value: 9.70e-11
|
||||||||||||||||
| SPT5 | COG5164 | Transcription elongation factor SPT5 [Transcription]; |
899-1031 | 1.43e-10 | ||||||||||||
Transcription elongation factor SPT5 [Transcription]; Pssm-ID: 444063 [Multi-domain] Cd Length: 495 Bit Score: 65.05 E-value: 1.43e-10
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
882-1033 | 1.82e-10 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 65.73 E-value: 1.82e-10
|
||||||||||||||||
| PHA03307 | PHA03307 | transcriptional regulator ICP4; Provisional |
883-1033 | 3.18e-10 | ||||||||||||
transcriptional regulator ICP4; Provisional Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 64.42 E-value: 3.18e-10
|
||||||||||||||||
| Chi1 | COG3469 | Chitinase [Carbohydrate transport and metabolism]; |
881-1038 | 3.57e-10 | ||||||||||||
Chitinase [Carbohydrate transport and metabolism]; Pssm-ID: 442692 [Multi-domain] Cd Length: 534 Bit Score: 63.62 E-value: 3.57e-10
|
||||||||||||||||
| PHA03307 | PHA03307 | transcriptional regulator ICP4; Provisional |
870-1012 | 4.17e-10 | ||||||||||||
transcriptional regulator ICP4; Provisional Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 64.04 E-value: 4.17e-10
|
||||||||||||||||
| PHA03378 | PHA03378 | EBNA-3B; Provisional |
875-1024 | 6.44e-10 | ||||||||||||
EBNA-3B; Provisional Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 63.55 E-value: 6.44e-10
|
||||||||||||||||
| SPT5 | COG5164 | Transcription elongation factor SPT5 [Transcription]; |
883-1041 | 9.00e-10 | ||||||||||||
Transcription elongation factor SPT5 [Transcription]; Pssm-ID: 444063 [Multi-domain] Cd Length: 495 Bit Score: 62.35 E-value: 9.00e-10
|
||||||||||||||||
| PHA03307 | PHA03307 | transcriptional regulator ICP4; Provisional |
882-1031 | 9.24e-10 | ||||||||||||
transcriptional regulator ICP4; Provisional Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 62.88 E-value: 9.24e-10
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
875-1021 | 1.10e-09 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 63.03 E-value: 1.10e-09
|
||||||||||||||||
| Atrophin-1 | pfam03154 | Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
867-1031 | 1.56e-09 | ||||||||||||
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity. Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 62.09 E-value: 1.56e-09
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
881-1025 | 1.59e-09 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 62.65 E-value: 1.59e-09
|
||||||||||||||||
| Atrophin-1 | pfam03154 | Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
859-1031 | 1.88e-09 | ||||||||||||
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity. Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 62.09 E-value: 1.88e-09
|
||||||||||||||||
| Chi1 | COG3469 | Chitinase [Carbohydrate transport and metabolism]; |
879-1013 | 1.89e-09 | ||||||||||||
Chitinase [Carbohydrate transport and metabolism]; Pssm-ID: 442692 [Multi-domain] Cd Length: 534 Bit Score: 61.31 E-value: 1.89e-09
|
||||||||||||||||
| PHA03378 | PHA03378 | EBNA-3B; Provisional |
875-1021 | 2.42e-09 | ||||||||||||
EBNA-3B; Provisional Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 61.62 E-value: 2.42e-09
|
||||||||||||||||
| Chi1 | COG3469 | Chitinase [Carbohydrate transport and metabolism]; |
845-1018 | 3.30e-09 | ||||||||||||
Chitinase [Carbohydrate transport and metabolism]; Pssm-ID: 442692 [Multi-domain] Cd Length: 534 Bit Score: 60.54 E-value: 3.30e-09
|
||||||||||||||||
| gly_rich_SclB | NF038329 | LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ... |
885-1022 | 3.53e-09 | ||||||||||||
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats. Pssm-ID: 468478 [Multi-domain] Cd Length: 440 Bit Score: 60.30 E-value: 3.53e-09
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
881-1021 | 4.38e-09 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 61.11 E-value: 4.38e-09
|
||||||||||||||||
| SPT5 | COG5164 | Transcription elongation factor SPT5 [Transcription]; |
908-1033 | 4.82e-09 | ||||||||||||
Transcription elongation factor SPT5 [Transcription]; Pssm-ID: 444063 [Multi-domain] Cd Length: 495 Bit Score: 60.04 E-value: 4.82e-09
|
||||||||||||||||
| PHA03307 | PHA03307 | transcriptional regulator ICP4; Provisional |
851-1030 | 7.17e-09 | ||||||||||||
transcriptional regulator ICP4; Provisional Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 60.18 E-value: 7.17e-09
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
886-1030 | 1.11e-08 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 59.57 E-value: 1.11e-08
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
885-1035 | 1.33e-08 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 59.57 E-value: 1.33e-08
|
||||||||||||||||
| gly_rich_SclB | NF038329 | LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ... |
882-1026 | 1.37e-08 | ||||||||||||
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats. Pssm-ID: 468478 [Multi-domain] Cd Length: 440 Bit Score: 58.38 E-value: 1.37e-08
|
||||||||||||||||
| PHA03307 | PHA03307 | transcriptional regulator ICP4; Provisional |
875-1031 | 2.29e-08 | ||||||||||||
transcriptional regulator ICP4; Provisional Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 58.64 E-value: 2.29e-08
|
||||||||||||||||
| PHA03378 | PHA03378 | EBNA-3B; Provisional |
850-1021 | 2.97e-08 | ||||||||||||
EBNA-3B; Provisional Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 58.15 E-value: 2.97e-08
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
875-1021 | 3.90e-08 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 58.03 E-value: 3.90e-08
|
||||||||||||||||
| PHA03378 | PHA03378 | EBNA-3B; Provisional |
876-1018 | 4.07e-08 | ||||||||||||
EBNA-3B; Provisional Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 57.77 E-value: 4.07e-08
|
||||||||||||||||
| Not5 | COG5665 | CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]; |
889-1021 | 4.23e-08 | ||||||||||||
CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]; Pssm-ID: 444384 [Multi-domain] Cd Length: 874 Bit Score: 57.37 E-value: 4.23e-08
|
||||||||||||||||
| PHA03307 | PHA03307 | transcriptional regulator ICP4; Provisional |
881-1010 | 4.28e-08 | ||||||||||||
transcriptional regulator ICP4; Provisional Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 57.49 E-value: 4.28e-08
|
||||||||||||||||
| vWA_C3HC4_type | cd01466 | VWA C3HC4-type: Von Willebrand factor type A (vWA) domain was originally found in the blood ... |
311-466 | 5.08e-08 | ||||||||||||
VWA C3HC4-type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Membes of this subgroup belong to Zinc-finger family as they are found fused to RING finger domains. The MIDAS motif is not conserved in all the members of this family. The function of vWA domains however is not known. Pssm-ID: 238743 [Multi-domain] Cd Length: 155 Bit Score: 53.16 E-value: 5.08e-08
|
||||||||||||||||
| gly_rich_SclB | NF038329 | LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ... |
912-1025 | 5.66e-08 | ||||||||||||
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats. Pssm-ID: 468478 [Multi-domain] Cd Length: 440 Bit Score: 56.45 E-value: 5.66e-08
|
||||||||||||||||
| Pro-rich | pfam15240 | Proline-rich protein; This family includes several eukaryotic proline-rich proteins. |
882-1021 | 6.74e-08 | ||||||||||||
Proline-rich protein; This family includes several eukaryotic proline-rich proteins. Pssm-ID: 464580 [Multi-domain] Cd Length: 167 Bit Score: 53.12 E-value: 6.74e-08
|
||||||||||||||||
| PHA03307 | PHA03307 | transcriptional regulator ICP4; Provisional |
881-1022 | 7.18e-08 | ||||||||||||
transcriptional regulator ICP4; Provisional Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 56.72 E-value: 7.18e-08
|
||||||||||||||||
| PHA03307 | PHA03307 | transcriptional regulator ICP4; Provisional |
854-1031 | 1.33e-07 | ||||||||||||
transcriptional regulator ICP4; Provisional Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 55.95 E-value: 1.33e-07
|
||||||||||||||||
| vWA_subgroup | cd01465 | VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood ... |
310-464 | 1.70e-07 | ||||||||||||
VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Not much is known about the function of the VWA domain in these proteins. The members do have a conserved MIDAS motif. The biochemical function however is not known. Pssm-ID: 238742 [Multi-domain] Cd Length: 170 Bit Score: 52.28 E-value: 1.70e-07
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
876-1030 | 2.29e-07 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 55.33 E-value: 2.29e-07
|
||||||||||||||||
| Pro-rich | pfam15240 | Proline-rich protein; This family includes several eukaryotic proline-rich proteins. |
875-1012 | 2.48e-07 | ||||||||||||
Proline-rich protein; This family includes several eukaryotic proline-rich proteins. Pssm-ID: 464580 [Multi-domain] Cd Length: 167 Bit Score: 51.58 E-value: 2.48e-07
|
||||||||||||||||
| vWA_BatA_type | cd01467 | VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood ... |
309-472 | 2.56e-07 | ||||||||||||
VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses. In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Members of this subgroup are bacterial in origin. They are typified by the presence of a MIDAS motif. Pssm-ID: 238744 [Multi-domain] Cd Length: 180 Bit Score: 51.95 E-value: 2.56e-07
|
||||||||||||||||
| PLN02217 | PLN02217 | probable pectinesterase/pectinesterase inhibitor |
849-1034 | 3.03e-07 | ||||||||||||
probable pectinesterase/pectinesterase inhibitor Pssm-ID: 215130 [Multi-domain] Cd Length: 670 Bit Score: 54.71 E-value: 3.03e-07
|
||||||||||||||||
| VWA_2 | pfam13519 | von Willebrand factor type A domain; |
311-416 | 3.54e-07 | ||||||||||||
von Willebrand factor type A domain; Pssm-ID: 463909 [Multi-domain] Cd Length: 103 Bit Score: 49.60 E-value: 3.54e-07
|
||||||||||||||||
| PHA03307 | PHA03307 | transcriptional regulator ICP4; Provisional |
899-1025 | 3.68e-07 | ||||||||||||
transcriptional regulator ICP4; Provisional Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 54.41 E-value: 3.68e-07
|
||||||||||||||||
| vWA_interalpha_trypsin_inhibitor | cd01461 | vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- ... |
307-471 | 3.89e-07 | ||||||||||||
vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to the extracellular matrix by binding to hyaluronic acid. The heavy chains carry the VWA domain with a conserved MIDAS motif. Although the exact role of the VWA domains remains unknown, it has been speculated to be involved in mediating protein-protein interactions with the components of the extracellular matrix. Pssm-ID: 238738 [Multi-domain] Cd Length: 171 Bit Score: 51.06 E-value: 3.89e-07
|
||||||||||||||||
| PHA03307 | PHA03307 | transcriptional regulator ICP4; Provisional |
874-1022 | 4.47e-07 | ||||||||||||
transcriptional regulator ICP4; Provisional Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 54.41 E-value: 4.47e-07
|
||||||||||||||||
| PHA03291 | PHA03291 | envelope glycoprotein I; Provisional |
913-1034 | 4.71e-07 | ||||||||||||
envelope glycoprotein I; Provisional Pssm-ID: 223033 [Multi-domain] Cd Length: 401 Bit Score: 53.42 E-value: 4.71e-07
|
||||||||||||||||
| PRK07764 | PRK07764 | DNA polymerase III subunits gamma and tau; Validated |
877-1030 | 5.07e-07 | ||||||||||||
DNA polymerase III subunits gamma and tau; Validated Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 53.84 E-value: 5.07e-07
|
||||||||||||||||
| acidobact_VWFA | TIGR03436 | VWFA-related Acidobacterial domain; Members of this family are bacterial domains that include ... |
307-476 | 5.52e-07 | ||||||||||||
VWFA-related Acidobacterial domain; Members of this family are bacterial domains that include a region related to the von Willebrand factor type A (VWFA) domain (pfam00092). These domains are restricted to, and have undergone a large paralogous family expansion in, the Acidobacteria, including Solibacter usitatus and Acidobacterium capsulatum ATCC 51196. Pssm-ID: 274577 [Multi-domain] Cd Length: 296 Bit Score: 52.69 E-value: 5.52e-07
|
||||||||||||||||
| PTZ00449 | PTZ00449 | 104 kDa microneme/rhoptry antigen; Provisional |
875-1021 | 6.24e-07 | ||||||||||||
104 kDa microneme/rhoptry antigen; Provisional Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 53.54 E-value: 6.24e-07
|
||||||||||||||||
| MISS | pfam15822 | MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ... |
875-1034 | 6.72e-07 | ||||||||||||
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest. Pssm-ID: 318115 [Multi-domain] Cd Length: 238 Bit Score: 51.53 E-value: 6.72e-07
|
||||||||||||||||
| Not5 | COG5665 | CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]; |
877-1020 | 7.82e-07 | ||||||||||||
CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]; Pssm-ID: 444384 [Multi-domain] Cd Length: 874 Bit Score: 53.51 E-value: 7.82e-07
|
||||||||||||||||
| PHA03378 | PHA03378 | EBNA-3B; Provisional |
875-1025 | 7.94e-07 | ||||||||||||
EBNA-3B; Provisional Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 53.53 E-value: 7.94e-07
|
||||||||||||||||
| vWA_subfamily | cd01464 | VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood ... |
309-458 | 8.45e-07 | ||||||||||||
VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Members of this subgroup have no assigned function. This subfamily is typified by the presence of a conserved MIDAS motif. Pssm-ID: 238741 [Multi-domain] Cd Length: 176 Bit Score: 50.42 E-value: 8.45e-07
|
||||||||||||||||
| PHA03307 | PHA03307 | transcriptional regulator ICP4; Provisional |
890-1034 | 8.58e-07 | ||||||||||||
transcriptional regulator ICP4; Provisional Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 53.25 E-value: 8.58e-07
|
||||||||||||||||
| PLN03209 | PLN03209 | translocon at the inner envelope of chloroplast subunit 62; Provisional |
880-1036 | 9.94e-07 | ||||||||||||
translocon at the inner envelope of chloroplast subunit 62; Provisional Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 52.62 E-value: 9.94e-07
|
||||||||||||||||
| DUF4045 | pfam13254 | Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ... |
882-1021 | 1.26e-06 | ||||||||||||
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length. Pssm-ID: 433066 [Multi-domain] Cd Length: 415 Bit Score: 52.09 E-value: 1.26e-06
|
||||||||||||||||
| PRK07764 | PRK07764 | DNA polymerase III subunits gamma and tau; Validated |
875-1031 | 1.29e-06 | ||||||||||||
DNA polymerase III subunits gamma and tau; Validated Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 52.68 E-value: 1.29e-06
|
||||||||||||||||
| PHA03307 | PHA03307 | transcriptional regulator ICP4; Provisional |
882-1021 | 1.55e-06 | ||||||||||||
transcriptional regulator ICP4; Provisional Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 52.48 E-value: 1.55e-06
|
||||||||||||||||
| PHA03307 | PHA03307 | transcriptional regulator ICP4; Provisional |
846-1022 | 1.62e-06 | ||||||||||||
transcriptional regulator ICP4; Provisional Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 52.48 E-value: 1.62e-06
|
||||||||||||||||
| PHA02682 | PHA02682 | ORF080 virion core protein; Provisional |
899-1027 | 1.70e-06 | ||||||||||||
ORF080 virion core protein; Provisional Pssm-ID: 177464 [Multi-domain] Cd Length: 280 Bit Score: 51.02 E-value: 1.70e-06
|
||||||||||||||||
| PHA03378 | PHA03378 | EBNA-3B; Provisional |
875-1000 | 1.81e-06 | ||||||||||||
EBNA-3B; Provisional Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 52.38 E-value: 1.81e-06
|
||||||||||||||||
| Herpes_BLLF1 | pfam05109 | Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
879-1024 | 1.96e-06 | ||||||||||||
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo. Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 52.23 E-value: 1.96e-06
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
874-1019 | 2.64e-06 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 51.86 E-value: 2.64e-06
|
||||||||||||||||
| Atrophin-1 | pfam03154 | Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
910-1031 | 2.81e-06 | ||||||||||||
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity. Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 51.69 E-value: 2.81e-06
|
||||||||||||||||
| PRK07764 | PRK07764 | DNA polymerase III subunits gamma and tau; Validated |
887-1013 | 2.83e-06 | ||||||||||||
DNA polymerase III subunits gamma and tau; Validated Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 51.53 E-value: 2.83e-06
|
||||||||||||||||
| KLF3_N | cd21577 | N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called ... |
883-1003 | 2.88e-06 | ||||||||||||
N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called Krueppel-like factor 3 and originally called Basic Kruppel-like Factor/BKLF), was the third member of the KLF family of zinc finger transcription factors to be discovered. KLF3 possesses a wide range of biological impacts on regulating apoptosis, differentiation, and proliferation in various tissues during the entire progression process. It has been proposed as a tumor suppressor in colorectal cancer. It appears to function predominantly as a repressor of transcription, turning genes off by recruiting the C-terminal Binding Protein co-repressors CtBP1 and CtBP2. CtBP docks onto a short motif (residues 61-65) in the N-terminus of KLF3, through the Proline-X-Aspartate-Leucine-Serine (PXDLS) motif. CtBP in turn recruits histone modifying enzymes to alter chromatin and repress gene expression. KLF3 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF3. Pssm-ID: 410554 [Multi-domain] Cd Length: 214 Bit Score: 49.27 E-value: 2.88e-06
|
||||||||||||||||
| Streccoc_I_II | NF033804 | antigen I/II family LPXTG-anchored adhesin; Members of the antigen I/II family are adhesins ... |
797-1025 | 3.27e-06 | ||||||||||||
antigen I/II family LPXTG-anchored adhesin; Members of the antigen I/II family are adhesins with a glucan-binding domain, two types of repetitive regions, an isopeptide bond-forming domain associated with shear resistance, and a C-terminal LPXTG motif for anchoring to the cell wall. They occur in oral Streptococci, and tend to be major cell surface adhesins. Members of this family include SspA and SspB from Streptococcus gordonii, antigen I/II from S. mutans, etc. Pssm-ID: 468188 [Multi-domain] Cd Length: 1552 Bit Score: 51.48 E-value: 3.27e-06
|
||||||||||||||||
| PHA02682 | PHA02682 | ORF080 virion core protein; Provisional |
881-1005 | 4.74e-06 | ||||||||||||
ORF080 virion core protein; Provisional Pssm-ID: 177464 [Multi-domain] Cd Length: 280 Bit Score: 49.47 E-value: 4.74e-06
|
||||||||||||||||
| PRK07764 | PRK07764 | DNA polymerase III subunits gamma and tau; Validated |
896-1022 | 4.92e-06 | ||||||||||||
DNA polymerase III subunits gamma and tau; Validated Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 50.75 E-value: 4.92e-06
|
||||||||||||||||
| PHA03291 | PHA03291 | envelope glycoprotein I; Provisional |
881-992 | 5.16e-06 | ||||||||||||
envelope glycoprotein I; Provisional Pssm-ID: 223033 [Multi-domain] Cd Length: 401 Bit Score: 49.95 E-value: 5.16e-06
|
||||||||||||||||
| PTZ00249 | PTZ00249 | variable surface protein Vir28; Provisional |
871-1020 | 5.63e-06 | ||||||||||||
variable surface protein Vir28; Provisional Pssm-ID: 140276 [Multi-domain] Cd Length: 516 Bit Score: 50.42 E-value: 5.63e-06
|
||||||||||||||||
| PRK07764 | PRK07764 | DNA polymerase III subunits gamma and tau; Validated |
905-1025 | 5.64e-06 | ||||||||||||
DNA polymerase III subunits gamma and tau; Validated Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 50.37 E-value: 5.64e-06
|
||||||||||||||||
| Pneumo_att_G | pfam05539 | Pneumovirinae attachment membrane glycoprotein G; |
876-1021 | 5.80e-06 | ||||||||||||
Pneumovirinae attachment membrane glycoprotein G; Pssm-ID: 114270 [Multi-domain] Cd Length: 408 Bit Score: 50.05 E-value: 5.80e-06
|
||||||||||||||||
| Herpes_BLLF1 | pfam05109 | Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
881-1033 | 5.80e-06 | ||||||||||||
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo. Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 50.69 E-value: 5.80e-06
|
||||||||||||||||
| PHA03291 | PHA03291 | envelope glycoprotein I; Provisional |
854-983 | 6.03e-06 | ||||||||||||
envelope glycoprotein I; Provisional Pssm-ID: 223033 [Multi-domain] Cd Length: 401 Bit Score: 49.95 E-value: 6.03e-06
|
||||||||||||||||
| PRK07003 | PRK07003 | DNA polymerase III subunit gamma/tau; |
882-1022 | 6.30e-06 | ||||||||||||
DNA polymerase III subunit gamma/tau; Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 50.23 E-value: 6.30e-06
|
||||||||||||||||
| PRK07764 | PRK07764 | DNA polymerase III subunits gamma and tau; Validated |
882-1004 | 6.85e-06 | ||||||||||||
DNA polymerase III subunits gamma and tau; Validated Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 50.37 E-value: 6.85e-06
|
||||||||||||||||
| VWA_YIEM_type | cd01462 | VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood ... |
308-448 | 7.27e-06 | ||||||||||||
VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Members of this subgroup have a conserved MIDAS motif, however, their biochemical function is not well characterised. Pssm-ID: 238739 [Multi-domain] Cd Length: 152 Bit Score: 46.96 E-value: 7.27e-06
|
||||||||||||||||
| PRK14959 | PRK14959 | DNA polymerase III subunits gamma and tau; Provisional |
885-1025 | 7.52e-06 | ||||||||||||
DNA polymerase III subunits gamma and tau; Provisional Pssm-ID: 184923 [Multi-domain] Cd Length: 624 Bit Score: 50.06 E-value: 7.52e-06
|
||||||||||||||||
| PRK14959 | PRK14959 | DNA polymerase III subunits gamma and tau; Provisional |
876-1016 | 7.52e-06 | ||||||||||||
DNA polymerase III subunits gamma and tau; Provisional Pssm-ID: 184923 [Multi-domain] Cd Length: 624 Bit Score: 50.06 E-value: 7.52e-06
|
||||||||||||||||
| NYAP_N | pfam15439 | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter; NYAP_N is an N-terminal ... |
875-1021 | 7.69e-06 | ||||||||||||
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter; NYAP_N is an N-terminal family of eukaryotic proteins that are substrates of tyrosine kinase in the brain. When first identified, the family members were referred to as unconventional myosin XVI, or Myr 8. However, proteins have now been identified as being integrally involved in neuronal function and morphogenesis. The family is involved in both the activation of phosphoinositide 3-kinase (PI3K) and the recruitment of the downstream effector WAVE complex to the close vicinity of PI3K; it also appears to regulate the brain size and neurite outgrowth in mice. Pssm-ID: 464717 [Multi-domain] Cd Length: 379 Bit Score: 49.39 E-value: 7.69e-06
|
||||||||||||||||
| half-pint | TIGR01645 | poly-U binding splicing factor, half-pint family; The proteins represented by this model ... |
843-1002 | 8.30e-06 | ||||||||||||
poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA. Pssm-ID: 130706 [Multi-domain] Cd Length: 612 Bit Score: 49.68 E-value: 8.30e-06
|
||||||||||||||||
| Pro-rich | pfam15240 | Proline-rich protein; This family includes several eukaryotic proline-rich proteins. |
900-1021 | 1.10e-05 | ||||||||||||
Proline-rich protein; This family includes several eukaryotic proline-rich proteins. Pssm-ID: 464580 [Multi-domain] Cd Length: 167 Bit Score: 46.95 E-value: 1.10e-05
|
||||||||||||||||
| Pneumo_att_G | pfam05539 | Pneumovirinae attachment membrane glycoprotein G; |
882-1033 | 1.23e-05 | ||||||||||||
Pneumovirinae attachment membrane glycoprotein G; Pssm-ID: 114270 [Multi-domain] Cd Length: 408 Bit Score: 48.89 E-value: 1.23e-05
|
||||||||||||||||
| PHA03307 | PHA03307 | transcriptional regulator ICP4; Provisional |
879-1013 | 1.27e-05 | ||||||||||||
transcriptional regulator ICP4; Provisional Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 49.40 E-value: 1.27e-05
|
||||||||||||||||
| PspC_subgroup_2 | NF033839 | pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ... |
880-1017 | 1.29e-05 | ||||||||||||
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. Pssm-ID: 468202 [Multi-domain] Cd Length: 557 Bit Score: 49.00 E-value: 1.29e-05
|
||||||||||||||||
| PRK12323 | PRK12323 | DNA polymerase III subunit gamma/tau; |
880-1024 | 1.61e-05 | ||||||||||||
DNA polymerase III subunit gamma/tau; Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 49.10 E-value: 1.61e-05
|
||||||||||||||||
| PRK12323 | PRK12323 | DNA polymerase III subunit gamma/tau; |
868-1021 | 1.75e-05 | ||||||||||||
DNA polymerase III subunit gamma/tau; Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 48.72 E-value: 1.75e-05
|
||||||||||||||||
| PHA02682 | PHA02682 | ORF080 virion core protein; Provisional |
917-1032 | 1.85e-05 | ||||||||||||
ORF080 virion core protein; Provisional Pssm-ID: 177464 [Multi-domain] Cd Length: 280 Bit Score: 47.55 E-value: 1.85e-05
|
||||||||||||||||
| PRK14950 | PRK14950 | DNA polymerase III subunits gamma and tau; Provisional |
880-967 | 1.85e-05 | ||||||||||||
DNA polymerase III subunits gamma and tau; Provisional Pssm-ID: 237864 [Multi-domain] Cd Length: 585 Bit Score: 48.65 E-value: 1.85e-05
|
||||||||||||||||
| KLF3_N | cd21577 | N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called ... |
881-994 | 2.42e-05 | ||||||||||||
N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called Krueppel-like factor 3 and originally called Basic Kruppel-like Factor/BKLF), was the third member of the KLF family of zinc finger transcription factors to be discovered. KLF3 possesses a wide range of biological impacts on regulating apoptosis, differentiation, and proliferation in various tissues during the entire progression process. It has been proposed as a tumor suppressor in colorectal cancer. It appears to function predominantly as a repressor of transcription, turning genes off by recruiting the C-terminal Binding Protein co-repressors CtBP1 and CtBP2. CtBP docks onto a short motif (residues 61-65) in the N-terminus of KLF3, through the Proline-X-Aspartate-Leucine-Serine (PXDLS) motif. CtBP in turn recruits histone modifying enzymes to alter chromatin and repress gene expression. KLF3 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF3. Pssm-ID: 410554 [Multi-domain] Cd Length: 214 Bit Score: 46.57 E-value: 2.42e-05
|
||||||||||||||||
| SOBP | pfam15279 | Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual ... |
873-994 | 2.53e-05 | ||||||||||||
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteriztic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein. Pssm-ID: 464609 [Multi-domain] Cd Length: 325 Bit Score: 47.50 E-value: 2.53e-05
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
881-1021 | 2.80e-05 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.40 E-value: 2.80e-05
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
882-1004 | 2.90e-05 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.40 E-value: 2.90e-05
|
||||||||||||||||
| PRK07003 | PRK07003 | DNA polymerase III subunit gamma/tau; |
882-1021 | 2.96e-05 | ||||||||||||
DNA polymerase III subunit gamma/tau; Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 48.31 E-value: 2.96e-05
|
||||||||||||||||
| PRK07003 | PRK07003 | DNA polymerase III subunit gamma/tau; |
876-1015 | 3.14e-05 | ||||||||||||
DNA polymerase III subunit gamma/tau; Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 47.92 E-value: 3.14e-05
|
||||||||||||||||
| PRK14950 | PRK14950 | DNA polymerase III subunits gamma and tau; Provisional |
926-1034 | 3.26e-05 | ||||||||||||
DNA polymerase III subunits gamma and tau; Provisional Pssm-ID: 237864 [Multi-domain] Cd Length: 585 Bit Score: 47.88 E-value: 3.26e-05
|
||||||||||||||||
| Metaviral_G | pfam09595 | Metaviral_G glycoprotein; This is a viral attachment glycoprotein from region G of metaviruses. ... |
892-1041 | 3.31e-05 | ||||||||||||
Metaviral_G glycoprotein; This is a viral attachment glycoprotein from region G of metaviruses. It is high in serine and threonine suggesting it is highly glycosylated. Pssm-ID: 462833 [Multi-domain] Cd Length: 183 Bit Score: 45.72 E-value: 3.31e-05
|
||||||||||||||||
| PRK07764 | PRK07764 | DNA polymerase III subunits gamma and tau; Validated |
882-995 | 3.95e-05 | ||||||||||||
DNA polymerase III subunits gamma and tau; Validated Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 47.67 E-value: 3.95e-05
|
||||||||||||||||
| DUF4045 | pfam13254 | Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ... |
891-1023 | 4.11e-05 | ||||||||||||
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length. Pssm-ID: 433066 [Multi-domain] Cd Length: 415 Bit Score: 47.08 E-value: 4.11e-05
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
895-1026 | 4.28e-05 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.01 E-value: 4.28e-05
|
||||||||||||||||
| Pro-rich | pfam15240 | Proline-rich protein; This family includes several eukaryotic proline-rich proteins. |
909-1022 | 4.29e-05 | ||||||||||||
Proline-rich protein; This family includes several eukaryotic proline-rich proteins. Pssm-ID: 464580 [Multi-domain] Cd Length: 167 Bit Score: 45.03 E-value: 4.29e-05
|
||||||||||||||||
| PRK14950 | PRK14950 | DNA polymerase III subunits gamma and tau; Provisional |
861-976 | 4.43e-05 | ||||||||||||
DNA polymerase III subunits gamma and tau; Provisional Pssm-ID: 237864 [Multi-domain] Cd Length: 585 Bit Score: 47.50 E-value: 4.43e-05
|
||||||||||||||||
| DUF5585 | pfam17823 | Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
881-1041 | 5.05e-05 | ||||||||||||
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 47.26 E-value: 5.05e-05
|
||||||||||||||||
| PRK14950 | PRK14950 | DNA polymerase III subunits gamma and tau; Provisional |
899-985 | 5.30e-05 | ||||||||||||
DNA polymerase III subunits gamma and tau; Provisional Pssm-ID: 237864 [Multi-domain] Cd Length: 585 Bit Score: 47.11 E-value: 5.30e-05
|
||||||||||||||||
| PRK14950 | PRK14950 | DNA polymerase III subunits gamma and tau; Provisional |
908-994 | 5.30e-05 | ||||||||||||
DNA polymerase III subunits gamma and tau; Provisional Pssm-ID: 237864 [Multi-domain] Cd Length: 585 Bit Score: 47.11 E-value: 5.30e-05
|
||||||||||||||||
| PRK14950 | PRK14950 | DNA polymerase III subunits gamma and tau; Provisional |
917-1003 | 5.30e-05 | ||||||||||||
DNA polymerase III subunits gamma and tau; Provisional Pssm-ID: 237864 [Multi-domain] Cd Length: 585 Bit Score: 47.11 E-value: 5.30e-05
|
||||||||||||||||
| PHA03307 | PHA03307 | transcriptional regulator ICP4; Provisional |
866-1028 | 5.86e-05 | ||||||||||||
transcriptional regulator ICP4; Provisional Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 47.47 E-value: 5.86e-05
|
||||||||||||||||
| PHA02682 | PHA02682 | ORF080 virion core protein; Provisional |
877-996 | 5.96e-05 | ||||||||||||
ORF080 virion core protein; Provisional Pssm-ID: 177464 [Multi-domain] Cd Length: 280 Bit Score: 46.01 E-value: 5.96e-05
|
||||||||||||||||
| motB | PRK12799 | flagellar motor protein MotB; Reviewed |
908-1019 | 6.43e-05 | ||||||||||||
flagellar motor protein MotB; Reviewed Pssm-ID: 183756 [Multi-domain] Cd Length: 421 Bit Score: 46.63 E-value: 6.43e-05
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
882-1030 | 6.74e-05 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 47.24 E-value: 6.74e-05
|
||||||||||||||||
| dnaA | PRK14086 | chromosomal replication initiator protein DnaA; |
805-1022 | 6.76e-05 | ||||||||||||
chromosomal replication initiator protein DnaA; Pssm-ID: 237605 [Multi-domain] Cd Length: 617 Bit Score: 46.74 E-value: 6.76e-05
|
||||||||||||||||
| Herpes_BLLF1 | pfam05109 | Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
874-1033 | 6.99e-05 | ||||||||||||
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo. Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 46.83 E-value: 6.99e-05
|
||||||||||||||||
| PHA03377 | PHA03377 | EBNA-3C; Provisional |
874-1011 | 8.55e-05 | ||||||||||||
EBNA-3C; Provisional Pssm-ID: 177614 [Multi-domain] Cd Length: 1000 Bit Score: 46.58 E-value: 8.55e-05
|
||||||||||||||||
| PHA03378 | PHA03378 | EBNA-3B; Provisional |
883-1021 | 8.74e-05 | ||||||||||||
EBNA-3B; Provisional Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 46.60 E-value: 8.74e-05
|
||||||||||||||||
| KLF3_N | cd21577 | N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called ... |
933-1021 | 8.95e-05 | ||||||||||||
N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called Krueppel-like factor 3 and originally called Basic Kruppel-like Factor/BKLF), was the third member of the KLF family of zinc finger transcription factors to be discovered. KLF3 possesses a wide range of biological impacts on regulating apoptosis, differentiation, and proliferation in various tissues during the entire progression process. It has been proposed as a tumor suppressor in colorectal cancer. It appears to function predominantly as a repressor of transcription, turning genes off by recruiting the C-terminal Binding Protein co-repressors CtBP1 and CtBP2. CtBP docks onto a short motif (residues 61-65) in the N-terminus of KLF3, through the Proline-X-Aspartate-Leucine-Serine (PXDLS) motif. CtBP in turn recruits histone modifying enzymes to alter chromatin and repress gene expression. KLF3 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF3. Pssm-ID: 410554 [Multi-domain] Cd Length: 214 Bit Score: 45.03 E-value: 8.95e-05
|
||||||||||||||||
| PRK12323 | PRK12323 | DNA polymerase III subunit gamma/tau; |
867-1020 | 8.99e-05 | ||||||||||||
DNA polymerase III subunit gamma/tau; Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 46.41 E-value: 8.99e-05
|
||||||||||||||||
| PRK12323 | PRK12323 | DNA polymerase III subunit gamma/tau; |
875-1022 | 9.07e-05 | ||||||||||||
DNA polymerase III subunit gamma/tau; Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 46.41 E-value: 9.07e-05
|
||||||||||||||||
| PRK07003 | PRK07003 | DNA polymerase III subunit gamma/tau; |
881-1021 | 9.25e-05 | ||||||||||||
DNA polymerase III subunit gamma/tau; Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 46.38 E-value: 9.25e-05
|
||||||||||||||||
| PRK07764 | PRK07764 | DNA polymerase III subunits gamma and tau; Validated |
875-986 | 1.02e-04 | ||||||||||||
DNA polymerase III subunits gamma and tau; Validated Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 46.52 E-value: 1.02e-04
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
873-1010 | 1.06e-04 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 46.47 E-value: 1.06e-04
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
886-1022 | 1.09e-04 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 46.47 E-value: 1.09e-04
|
||||||||||||||||
| PHA03132 | PHA03132 | thymidine kinase; Provisional |
878-1013 | 1.24e-04 | ||||||||||||
thymidine kinase; Provisional Pssm-ID: 222997 [Multi-domain] Cd Length: 580 Bit Score: 45.91 E-value: 1.24e-04
|
||||||||||||||||
| KLF3_N | cd21577 | N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called ... |
888-1012 | 1.60e-04 | ||||||||||||
N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called Krueppel-like factor 3 and originally called Basic Kruppel-like Factor/BKLF), was the third member of the KLF family of zinc finger transcription factors to be discovered. KLF3 possesses a wide range of biological impacts on regulating apoptosis, differentiation, and proliferation in various tissues during the entire progression process. It has been proposed as a tumor suppressor in colorectal cancer. It appears to function predominantly as a repressor of transcription, turning genes off by recruiting the C-terminal Binding Protein co-repressors CtBP1 and CtBP2. CtBP docks onto a short motif (residues 61-65) in the N-terminus of KLF3, through the Proline-X-Aspartate-Leucine-Serine (PXDLS) motif. CtBP in turn recruits histone modifying enzymes to alter chromatin and repress gene expression. KLF3 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF3. Pssm-ID: 410554 [Multi-domain] Cd Length: 214 Bit Score: 44.26 E-value: 1.60e-04
|
||||||||||||||||
| DUF5585 | pfam17823 | Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
888-1033 | 1.61e-04 | ||||||||||||
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 45.34 E-value: 1.61e-04
|
||||||||||||||||
| vWA_micronemal_protein | cd01471 | Micronemal proteins: The Toxoplasma lytic cycle begins when the parasite actively invades a ... |
309-444 | 1.66e-04 | ||||||||||||
Micronemal proteins: The Toxoplasma lytic cycle begins when the parasite actively invades a target cell. In association with invasion, T. gondii sequentially discharges three sets of secretory organelles beginning with the micronemes, which contain adhesive proteins involved in parasite attachment to a host cell. Deployed as protein complexes, several micronemal proteins possess vertebrate-derived adhesive sequences that function in binding receptors. The VWA domain likely mediates the protein-protein interactions of these with their interacting partners. Pssm-ID: 238748 [Multi-domain] Cd Length: 186 Bit Score: 43.53 E-value: 1.66e-04
|
||||||||||||||||
| Hamartin | pfam04388 | Hamartin protein; This family includes the hamartin protein which is thought to function as a ... |
928-1024 | 1.75e-04 | ||||||||||||
Hamartin protein; This family includes the hamartin protein which is thought to function as a tumour suppressor. The hamartin protein interacts with the tuberin protein pfam03542. Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is characterized by the presence of hamartomas in many organs, such as brain, skin, heart, lung, and kidney. It is caused by mutation either TSC1 or TSC2 tumour suppressor gene. TSC1 encodes a protein, hamartin, containing two coiled-coil regions, which have been shown to mediate binding to tuberin. The TSC2 gene codes for tuberin pfam03542. These two proteins function within the same pathway(s) regulating cell cycle, cell growth, adhesion, and vesicular trafficking. Pssm-ID: 461287 [Multi-domain] Cd Length: 730 Bit Score: 45.43 E-value: 1.75e-04
|
||||||||||||||||
| PRK07003 | PRK07003 | DNA polymerase III subunit gamma/tau; |
882-1020 | 1.92e-04 | ||||||||||||
DNA polymerase III subunit gamma/tau; Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 45.61 E-value: 1.92e-04
|
||||||||||||||||
| Pneumo_att_G | pfam05539 | Pneumovirinae attachment membrane glycoprotein G; |
875-1009 | 1.99e-04 | ||||||||||||
Pneumovirinae attachment membrane glycoprotein G; Pssm-ID: 114270 [Multi-domain] Cd Length: 408 Bit Score: 45.04 E-value: 1.99e-04
|
||||||||||||||||
| motB | PRK12799 | flagellar motor protein MotB; Reviewed |
877-1010 | 2.08e-04 | ||||||||||||
flagellar motor protein MotB; Reviewed Pssm-ID: 183756 [Multi-domain] Cd Length: 421 Bit Score: 45.09 E-value: 2.08e-04
|
||||||||||||||||
| Nucleoporin_FG2 | pfam15967 | Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of ... |
886-1024 | 2.14e-04 | ||||||||||||
Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of chordate nucleoporins. The proteins carry many repeats of the FG sequence motif. Pssm-ID: 435043 [Multi-domain] Cd Length: 586 Bit Score: 45.04 E-value: 2.14e-04
|
||||||||||||||||
| KLF3_N | cd21577 | N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called ... |
951-1029 | 2.16e-04 | ||||||||||||
N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called Krueppel-like factor 3 and originally called Basic Kruppel-like Factor/BKLF), was the third member of the KLF family of zinc finger transcription factors to be discovered. KLF3 possesses a wide range of biological impacts on regulating apoptosis, differentiation, and proliferation in various tissues during the entire progression process. It has been proposed as a tumor suppressor in colorectal cancer. It appears to function predominantly as a repressor of transcription, turning genes off by recruiting the C-terminal Binding Protein co-repressors CtBP1 and CtBP2. CtBP docks onto a short motif (residues 61-65) in the N-terminus of KLF3, through the Proline-X-Aspartate-Leucine-Serine (PXDLS) motif. CtBP in turn recruits histone modifying enzymes to alter chromatin and repress gene expression. KLF3 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF3. Pssm-ID: 410554 [Multi-domain] Cd Length: 214 Bit Score: 43.87 E-value: 2.16e-04
|
||||||||||||||||
| PRK14950 | PRK14950 | DNA polymerase III subunits gamma and tau; Provisional |
860-958 | 2.25e-04 | ||||||||||||
DNA polymerase III subunits gamma and tau; Provisional Pssm-ID: 237864 [Multi-domain] Cd Length: 585 Bit Score: 45.19 E-value: 2.25e-04
|
||||||||||||||||
| PRK07003 | PRK07003 | DNA polymerase III subunit gamma/tau; |
883-1022 | 2.38e-04 | ||||||||||||
DNA polymerase III subunit gamma/tau; Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 45.23 E-value: 2.38e-04
|
||||||||||||||||
| PRK14959 | PRK14959 | DNA polymerase III subunits gamma and tau; Provisional |
875-998 | 2.46e-04 | ||||||||||||
DNA polymerase III subunits gamma and tau; Provisional Pssm-ID: 184923 [Multi-domain] Cd Length: 624 Bit Score: 45.06 E-value: 2.46e-04
|
||||||||||||||||
| PTZ00249 | PTZ00249 | variable surface protein Vir28; Provisional |
829-984 | 3.53e-04 | ||||||||||||
variable surface protein Vir28; Provisional Pssm-ID: 140276 [Multi-domain] Cd Length: 516 Bit Score: 44.25 E-value: 3.53e-04
|
||||||||||||||||
| DUF4045 | pfam13254 | Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ... |
900-1032 | 4.03e-04 | ||||||||||||
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length. Pssm-ID: 433066 [Multi-domain] Cd Length: 415 Bit Score: 44.00 E-value: 4.03e-04
|
||||||||||||||||
| PRK07003 | PRK07003 | DNA polymerase III subunit gamma/tau; |
854-1021 | 4.20e-04 | ||||||||||||
DNA polymerase III subunit gamma/tau; Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 44.46 E-value: 4.20e-04
|
||||||||||||||||
| PRK14951 | PRK14951 | DNA polymerase III subunits gamma and tau; Provisional |
885-1041 | 4.21e-04 | ||||||||||||
DNA polymerase III subunits gamma and tau; Provisional Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 44.32 E-value: 4.21e-04
|
||||||||||||||||
| PTZ00249 | PTZ00249 | variable surface protein Vir28; Provisional |
905-1021 | 5.51e-04 | ||||||||||||
variable surface protein Vir28; Provisional Pssm-ID: 140276 [Multi-domain] Cd Length: 516 Bit Score: 43.87 E-value: 5.51e-04
|
||||||||||||||||
| vWFA_subfamily_ECM | cd01450 | Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ... |
311-456 | 5.58e-04 | ||||||||||||
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains Pssm-ID: 238727 [Multi-domain] Cd Length: 161 Bit Score: 41.51 E-value: 5.58e-04
|
||||||||||||||||
| PLN03209 | PLN03209 | translocon at the inner envelope of chloroplast subunit 62; Provisional |
859-1028 | 6.11e-04 | ||||||||||||
translocon at the inner envelope of chloroplast subunit 62; Provisional Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 43.76 E-value: 6.11e-04
|
||||||||||||||||
| Herpes_BLLF1 | pfam05109 | Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
872-1031 | 6.93e-04 | ||||||||||||
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo. Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 43.75 E-value: 6.93e-04
|
||||||||||||||||
| PRK07003 | PRK07003 | DNA polymerase III subunit gamma/tau; |
886-1030 | 8.15e-04 | ||||||||||||
DNA polymerase III subunit gamma/tau; Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 43.30 E-value: 8.15e-04
|
||||||||||||||||
| KLF3_N | cd21577 | N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called ... |
875-985 | 1.00e-03 | ||||||||||||
N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called Krueppel-like factor 3 and originally called Basic Kruppel-like Factor/BKLF), was the third member of the KLF family of zinc finger transcription factors to be discovered. KLF3 possesses a wide range of biological impacts on regulating apoptosis, differentiation, and proliferation in various tissues during the entire progression process. It has been proposed as a tumor suppressor in colorectal cancer. It appears to function predominantly as a repressor of transcription, turning genes off by recruiting the C-terminal Binding Protein co-repressors CtBP1 and CtBP2. CtBP docks onto a short motif (residues 61-65) in the N-terminus of KLF3, through the Proline-X-Aspartate-Leucine-Serine (PXDLS) motif. CtBP in turn recruits histone modifying enzymes to alter chromatin and repress gene expression. KLF3 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF3. Pssm-ID: 410554 [Multi-domain] Cd Length: 214 Bit Score: 41.56 E-value: 1.00e-03
|
||||||||||||||||
| KLF3_N | cd21577 | N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called ... |
960-1038 | 1.02e-03 | ||||||||||||
N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called Krueppel-like factor 3 and originally called Basic Kruppel-like Factor/BKLF), was the third member of the KLF family of zinc finger transcription factors to be discovered. KLF3 possesses a wide range of biological impacts on regulating apoptosis, differentiation, and proliferation in various tissues during the entire progression process. It has been proposed as a tumor suppressor in colorectal cancer. It appears to function predominantly as a repressor of transcription, turning genes off by recruiting the C-terminal Binding Protein co-repressors CtBP1 and CtBP2. CtBP docks onto a short motif (residues 61-65) in the N-terminus of KLF3, through the Proline-X-Aspartate-Leucine-Serine (PXDLS) motif. CtBP in turn recruits histone modifying enzymes to alter chromatin and repress gene expression. KLF3 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF3. Pssm-ID: 410554 [Multi-domain] Cd Length: 214 Bit Score: 41.56 E-value: 1.02e-03
|
||||||||||||||||
| DUF5585 | pfam17823 | Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
889-1033 | 1.13e-03 | ||||||||||||
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 42.64 E-value: 1.13e-03
|
||||||||||||||||
| PspC_subgroup_2 | NF033839 | pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ... |
715-1017 | 1.17e-03 | ||||||||||||
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. Pssm-ID: 468202 [Multi-domain] Cd Length: 557 Bit Score: 42.83 E-value: 1.17e-03
|
||||||||||||||||
| PHA03307 | PHA03307 | transcriptional regulator ICP4; Provisional |
889-1003 | 1.19e-03 | ||||||||||||
transcriptional regulator ICP4; Provisional Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.24 E-value: 1.19e-03
|
||||||||||||||||
| PHA03377 | PHA03377 | EBNA-3C; Provisional |
875-1020 | 1.21e-03 | ||||||||||||
EBNA-3C; Provisional Pssm-ID: 177614 [Multi-domain] Cd Length: 1000 Bit Score: 43.12 E-value: 1.21e-03
|
||||||||||||||||
| PRK14948 | PRK14948 | DNA polymerase III subunit gamma/tau; |
844-967 | 1.30e-03 | ||||||||||||
DNA polymerase III subunit gamma/tau; Pssm-ID: 237862 [Multi-domain] Cd Length: 620 Bit Score: 42.64 E-value: 1.30e-03
|
||||||||||||||||
| PHA03369 | PHA03369 | capsid maturational protease; Provisional |
906-1016 | 1.57e-03 | ||||||||||||
capsid maturational protease; Provisional Pssm-ID: 223061 [Multi-domain] Cd Length: 663 Bit Score: 42.29 E-value: 1.57e-03
|
||||||||||||||||
| PHA03369 | PHA03369 | capsid maturational protease; Provisional |
897-1007 | 1.57e-03 | ||||||||||||
capsid maturational protease; Provisional Pssm-ID: 223061 [Multi-domain] Cd Length: 663 Bit Score: 42.29 E-value: 1.57e-03
|
||||||||||||||||
| PHA03369 | PHA03369 | capsid maturational protease; Provisional |
888-998 | 1.57e-03 | ||||||||||||
capsid maturational protease; Provisional Pssm-ID: 223061 [Multi-domain] Cd Length: 663 Bit Score: 42.29 E-value: 1.57e-03
|
||||||||||||||||
| half-pint | TIGR01645 | poly-U binding splicing factor, half-pint family; The proteins represented by this model ... |
911-1040 | 1.69e-03 | ||||||||||||
poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA. Pssm-ID: 130706 [Multi-domain] Cd Length: 612 Bit Score: 42.36 E-value: 1.69e-03
|
||||||||||||||||
| SP6_N | cd22544 | N-terminal domain of transcription factor Specificity Protein (SP) 6; Specificity Proteins ... |
875-1030 | 1.69e-03 | ||||||||||||
N-terminal domain of transcription factor Specificity Protein (SP) 6; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP6, also known as epiprofin, shows specific expression pattern in hair follicles and the apical ectodermal ridge (AER) of the developing limbs. SP6 null mice are nude and show defects in skin, teeth, limbs (syndactyly and oligodactyly), and lung alveoli. SP6 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. This model represents the N-terminal domain of SP6. Pssm-ID: 411693 [Multi-domain] Cd Length: 245 Bit Score: 41.44 E-value: 1.69e-03
|
||||||||||||||||
| PRK12323 | PRK12323 | DNA polymerase III subunit gamma/tau; |
900-1031 | 1.79e-03 | ||||||||||||
DNA polymerase III subunit gamma/tau; Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 42.17 E-value: 1.79e-03
|
||||||||||||||||
| DUF3729 | pfam12526 | Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins ... |
916-995 | 1.81e-03 | ||||||||||||
Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins in this family are typically between 145 and 1707 amino acids in length. The family is found in association with pfam01443, pfam01661, pfam05417, pfam01660, pfam00978. There is a single completely conserved residue L that may be functionally important. Pssm-ID: 372164 [Multi-domain] Cd Length: 115 Bit Score: 39.29 E-value: 1.81e-03
|
||||||||||||||||
| DUF3729 | pfam12526 | Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins ... |
898-977 | 1.81e-03 | ||||||||||||
Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins in this family are typically between 145 and 1707 amino acids in length. The family is found in association with pfam01443, pfam01661, pfam05417, pfam01660, pfam00978. There is a single completely conserved residue L that may be functionally important. Pssm-ID: 372164 [Multi-domain] Cd Length: 115 Bit Score: 39.29 E-value: 1.81e-03
|
||||||||||||||||
| DUF3729 | pfam12526 | Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins ... |
925-1004 | 1.81e-03 | ||||||||||||
Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins in this family are typically between 145 and 1707 amino acids in length. The family is found in association with pfam01443, pfam01661, pfam05417, pfam01660, pfam00978. There is a single completely conserved residue L that may be functionally important. Pssm-ID: 372164 [Multi-domain] Cd Length: 115 Bit Score: 39.29 E-value: 1.81e-03
|
||||||||||||||||
| DUF3729 | pfam12526 | Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins ... |
943-1022 | 1.81e-03 | ||||||||||||
Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins in this family are typically between 145 and 1707 amino acids in length. The family is found in association with pfam01443, pfam01661, pfam05417, pfam01660, pfam00978. There is a single completely conserved residue L that may be functionally important. Pssm-ID: 372164 [Multi-domain] Cd Length: 115 Bit Score: 39.29 E-value: 1.81e-03
|
||||||||||||||||
| DUF3729 | pfam12526 | Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins ... |
907-986 | 1.81e-03 | ||||||||||||
Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins in this family are typically between 145 and 1707 amino acids in length. The family is found in association with pfam01443, pfam01661, pfam05417, pfam01660, pfam00978. There is a single completely conserved residue L that may be functionally important. Pssm-ID: 372164 [Multi-domain] Cd Length: 115 Bit Score: 39.29 E-value: 1.81e-03
|
||||||||||||||||
| DUF3729 | pfam12526 | Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins ... |
889-968 | 1.81e-03 | ||||||||||||
Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins in this family are typically between 145 and 1707 amino acids in length. The family is found in association with pfam01443, pfam01661, pfam05417, pfam01660, pfam00978. There is a single completely conserved residue L that may be functionally important. Pssm-ID: 372164 [Multi-domain] Cd Length: 115 Bit Score: 39.29 E-value: 1.81e-03
|
||||||||||||||||
| KLF9_13_N-like | cd21975 | Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like ... |
894-1026 | 1.88e-03 | ||||||||||||
Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF9, KLF13, KLF14, KLF16, and similar proteins. Pssm-ID: 409240 [Multi-domain] Cd Length: 163 Bit Score: 40.06 E-value: 1.88e-03
|
||||||||||||||||
| motB | PRK12799 | flagellar motor protein MotB; Reviewed |
916-1031 | 1.97e-03 | ||||||||||||
flagellar motor protein MotB; Reviewed Pssm-ID: 183756 [Multi-domain] Cd Length: 421 Bit Score: 42.01 E-value: 1.97e-03
|
||||||||||||||||
| vWA_Magnesium_chelatase | cd01451 | Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). ... |
307-422 | 1.97e-03 | ||||||||||||
Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is a three sub-unit (BchI, BchD and BchH) enzyme with a novel arrangement of domains: the C-terminal helical domain is located behind the nucleotide binding site. The BchD domain contains a AAA domain at its N-terminus and a VWA domain at its C-terminus. The VWA domain has been speculated to be involved in mediating protein-protein interactions. Pssm-ID: 238728 [Multi-domain] Cd Length: 178 Bit Score: 40.34 E-value: 1.97e-03
|
||||||||||||||||
| PHA03307 | PHA03307 | transcriptional regulator ICP4; Provisional |
881-994 | 2.01e-03 | ||||||||||||
transcriptional regulator ICP4; Provisional Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 42.47 E-value: 2.01e-03
|
||||||||||||||||
| DUF3729 | pfam12526 | Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins ... |
885-959 | 2.05e-03 | ||||||||||||
Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins in this family are typically between 145 and 1707 amino acids in length. The family is found in association with pfam01443, pfam01661, pfam05417, pfam01660, pfam00978. There is a single completely conserved residue L that may be functionally important. Pssm-ID: 372164 [Multi-domain] Cd Length: 115 Bit Score: 38.91 E-value: 2.05e-03
|
||||||||||||||||
| dnaA | PRK14086 | chromosomal replication initiator protein DnaA; |
881-1012 | 2.13e-03 | ||||||||||||
chromosomal replication initiator protein DnaA; Pssm-ID: 237605 [Multi-domain] Cd Length: 617 Bit Score: 42.12 E-value: 2.13e-03
|
||||||||||||||||
| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
881-977 | 2.16e-03 | ||||||||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 42.23 E-value: 2.16e-03
|
||||||||||||||||
| KLF9_13_N-like | cd21975 | Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like ... |
885-1021 | 2.23e-03 | ||||||||||||
Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF9, KLF13, KLF14, KLF16, and similar proteins. Pssm-ID: 409240 [Multi-domain] Cd Length: 163 Bit Score: 40.06 E-value: 2.23e-03
|
||||||||||||||||
| KLF3_N | cd21577 | N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called ... |
874-976 | 2.45e-03 | ||||||||||||
N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called Krueppel-like factor 3 and originally called Basic Kruppel-like Factor/BKLF), was the third member of the KLF family of zinc finger transcription factors to be discovered. KLF3 possesses a wide range of biological impacts on regulating apoptosis, differentiation, and proliferation in various tissues during the entire progression process. It has been proposed as a tumor suppressor in colorectal cancer. It appears to function predominantly as a repressor of transcription, turning genes off by recruiting the C-terminal Binding Protein co-repressors CtBP1 and CtBP2. CtBP docks onto a short motif (residues 61-65) in the N-terminus of KLF3, through the Proline-X-Aspartate-Leucine-Serine (PXDLS) motif. CtBP in turn recruits histone modifying enzymes to alter chromatin and repress gene expression. KLF3 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF3. Pssm-ID: 410554 [Multi-domain] Cd Length: 214 Bit Score: 40.41 E-value: 2.45e-03
|
||||||||||||||||
| PHA03369 | PHA03369 | capsid maturational protease; Provisional |
838-953 | 2.45e-03 | ||||||||||||
capsid maturational protease; Provisional Pssm-ID: 223061 [Multi-domain] Cd Length: 663 Bit Score: 41.91 E-value: 2.45e-03
|
||||||||||||||||
| SAV_2336_NTERM | NF041121 | SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ... |
945-1031 | 2.71e-03 | ||||||||||||
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems. Pssm-ID: 469044 [Multi-domain] Cd Length: 473 Bit Score: 41.53 E-value: 2.71e-03
|
||||||||||||||||
| Herpes_BLLF1 | pfam05109 | Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
883-1016 | 2.91e-03 | ||||||||||||
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo. Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 41.83 E-value: 2.91e-03
|
||||||||||||||||
| dnaA | PRK14086 | chromosomal replication initiator protein DnaA; |
875-1003 | 2.97e-03 | ||||||||||||
chromosomal replication initiator protein DnaA; Pssm-ID: 237605 [Multi-domain] Cd Length: 617 Bit Score: 41.35 E-value: 2.97e-03
|
||||||||||||||||
| PRK14951 | PRK14951 | DNA polymerase III subunits gamma and tau; Provisional |
876-1013 | 3.10e-03 | ||||||||||||
DNA polymerase III subunits gamma and tau; Provisional Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 41.62 E-value: 3.10e-03
|
||||||||||||||||
| Nucleoporin_FG2 | pfam15967 | Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of ... |
887-1024 | 3.17e-03 | ||||||||||||
Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of chordate nucleoporins. The proteins carry many repeats of the FG sequence motif. Pssm-ID: 435043 [Multi-domain] Cd Length: 586 Bit Score: 41.58 E-value: 3.17e-03
|
||||||||||||||||
| PHA03369 | PHA03369 | capsid maturational protease; Provisional |
877-980 | 3.31e-03 | ||||||||||||
capsid maturational protease; Provisional Pssm-ID: 223061 [Multi-domain] Cd Length: 663 Bit Score: 41.52 E-value: 3.31e-03
|
||||||||||||||||
| PHA03369 | PHA03369 | capsid maturational protease; Provisional |
915-1021 | 3.76e-03 | ||||||||||||
capsid maturational protease; Provisional Pssm-ID: 223061 [Multi-domain] Cd Length: 663 Bit Score: 41.14 E-value: 3.76e-03
|
||||||||||||||||
| KREPA2 | cd23959 | Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of ... |
890-1010 | 3.76e-03 | ||||||||||||
Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of the parasitic protozoan's KREPA RNA editing catalytic complex (RECC). Kinetoplastid RNA editing (KRE) proteins occur as pairs or sets of related proteins in multiple complexes. KREPA complex is composed of six components (KREPA1-6), which share a conserved C-terminal region containing an oligonucleotide-binding (OB)-fold-like domain. KREPAs are responsible for the site-specific insertion and deletion of U nucleotides in the kinetoplastid mitochondria pre-messenger RNA. Apart from the conserved C-terminal OB-fold domain, KREPA1, KREPA2, and KREPA3 contain two conserved C2H2 zinc-finger domains. KREPA2 and kinetoplastid RNA editing ligase 1 (KREL1) are specific for ligation post-U-deletion and are paralogous to KREL2 and KREPA1 that are specific for ligation post-U-insertion. KREPA2, is critical for RECC stability and KREL1 integration into the complex. Pssm-ID: 467780 [Multi-domain] Cd Length: 424 Bit Score: 41.01 E-value: 3.76e-03
|
||||||||||||||||
| PBP1 | COG5180 | PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ... |
883-1020 | 4.54e-03 | ||||||||||||
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; Pssm-ID: 444064 [Multi-domain] Cd Length: 548 Bit Score: 40.82 E-value: 4.54e-03
|
||||||||||||||||
| PBP1 | COG5180 | PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ... |
874-1032 | 4.95e-03 | ||||||||||||
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; Pssm-ID: 444064 [Multi-domain] Cd Length: 548 Bit Score: 40.82 E-value: 4.95e-03
|
||||||||||||||||
| PRK10856 | PRK10856 | cytoskeleton protein RodZ; |
888-976 | 5.22e-03 | ||||||||||||
cytoskeleton protein RodZ; Pssm-ID: 236776 [Multi-domain] Cd Length: 331 Bit Score: 40.39 E-value: 5.22e-03
|
||||||||||||||||
| PRK10856 | PRK10856 | cytoskeleton protein RodZ; |
897-985 | 5.22e-03 | ||||||||||||
cytoskeleton protein RodZ; Pssm-ID: 236776 [Multi-domain] Cd Length: 331 Bit Score: 40.39 E-value: 5.22e-03
|
||||||||||||||||
| PRK10856 | PRK10856 | cytoskeleton protein RodZ; |
906-994 | 5.22e-03 | ||||||||||||
cytoskeleton protein RodZ; Pssm-ID: 236776 [Multi-domain] Cd Length: 331 Bit Score: 40.39 E-value: 5.22e-03
|
||||||||||||||||
| PRK10856 | PRK10856 | cytoskeleton protein RodZ; |
915-1003 | 5.22e-03 | ||||||||||||
cytoskeleton protein RodZ; Pssm-ID: 236776 [Multi-domain] Cd Length: 331 Bit Score: 40.39 E-value: 5.22e-03
|
||||||||||||||||
| PRK10856 | PRK10856 | cytoskeleton protein RodZ; |
924-1012 | 5.22e-03 | ||||||||||||
cytoskeleton protein RodZ; Pssm-ID: 236776 [Multi-domain] Cd Length: 331 Bit Score: 40.39 E-value: 5.22e-03
|
||||||||||||||||
| PRK10856 | PRK10856 | cytoskeleton protein RodZ; |
933-1021 | 5.22e-03 | ||||||||||||
cytoskeleton protein RodZ; Pssm-ID: 236776 [Multi-domain] Cd Length: 331 Bit Score: 40.39 E-value: 5.22e-03
|
||||||||||||||||
| kgd | PRK12270 | multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ... |
885-959 | 5.62e-03 | ||||||||||||
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit; Pssm-ID: 237030 [Multi-domain] Cd Length: 1228 Bit Score: 40.64 E-value: 5.62e-03
|
||||||||||||||||
| kgd | PRK12270 | multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ... |
894-968 | 5.62e-03 | ||||||||||||
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit; Pssm-ID: 237030 [Multi-domain] Cd Length: 1228 Bit Score: 40.64 E-value: 5.62e-03
|
||||||||||||||||
| kgd | PRK12270 | multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ... |
903-977 | 5.62e-03 | ||||||||||||
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit; Pssm-ID: 237030 [Multi-domain] Cd Length: 1228 Bit Score: 40.64 E-value: 5.62e-03
|
||||||||||||||||
| kgd | PRK12270 | multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ... |
912-986 | 5.62e-03 | ||||||||||||
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit; Pssm-ID: 237030 [Multi-domain] Cd Length: 1228 Bit Score: 40.64 E-value: 5.62e-03
|
||||||||||||||||
| kgd | PRK12270 | multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ... |
921-995 | 5.62e-03 | ||||||||||||
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit; Pssm-ID: 237030 [Multi-domain] Cd Length: 1228 Bit Score: 40.64 E-value: 5.62e-03
|
||||||||||||||||
| kgd | PRK12270 | multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ... |
930-1004 | 5.62e-03 | ||||||||||||
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit; Pssm-ID: 237030 [Multi-domain] Cd Length: 1228 Bit Score: 40.64 E-value: 5.62e-03
|
||||||||||||||||
| kgd | PRK12270 | multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ... |
939-1013 | 5.62e-03 | ||||||||||||
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit; Pssm-ID: 237030 [Multi-domain] Cd Length: 1228 Bit Score: 40.64 E-value: 5.62e-03
|
||||||||||||||||
| kgd | PRK12270 | multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ... |
948-1022 | 5.62e-03 | ||||||||||||
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit; Pssm-ID: 237030 [Multi-domain] Cd Length: 1228 Bit Score: 40.64 E-value: 5.62e-03
|
||||||||||||||||
| PRK07764 | PRK07764 | DNA polymerase III subunits gamma and tau; Validated |
882-1002 | 6.48e-03 | ||||||||||||
DNA polymerase III subunits gamma and tau; Validated Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 40.35 E-value: 6.48e-03
|
||||||||||||||||
| SAV_2336_NTERM | NF041121 | SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ... |
927-1014 | 6.56e-03 | ||||||||||||
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems. Pssm-ID: 469044 [Multi-domain] Cd Length: 473 Bit Score: 40.37 E-value: 6.56e-03
|
||||||||||||||||
| SAV_2336_NTERM | NF041121 | SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ... |
918-1005 | 6.56e-03 | ||||||||||||
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems. Pssm-ID: 469044 [Multi-domain] Cd Length: 473 Bit Score: 40.37 E-value: 6.56e-03
|
||||||||||||||||
| SAV_2336_NTERM | NF041121 | SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ... |
909-996 | 6.56e-03 | ||||||||||||
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems. Pssm-ID: 469044 [Multi-domain] Cd Length: 473 Bit Score: 40.37 E-value: 6.56e-03
|
||||||||||||||||
| SAV_2336_NTERM | NF041121 | SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ... |
900-987 | 6.56e-03 | ||||||||||||
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems. Pssm-ID: 469044 [Multi-domain] Cd Length: 473 Bit Score: 40.37 E-value: 6.56e-03
|
||||||||||||||||
| SAV_2336_NTERM | NF041121 | SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ... |
891-978 | 6.56e-03 | ||||||||||||
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems. Pssm-ID: 469044 [Multi-domain] Cd Length: 473 Bit Score: 40.37 E-value: 6.56e-03
|
||||||||||||||||
| SAV_2336_NTERM | NF041121 | SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ... |
936-1023 | 6.56e-03 | ||||||||||||
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems. Pssm-ID: 469044 [Multi-domain] Cd Length: 473 Bit Score: 40.37 E-value: 6.56e-03
|
||||||||||||||||
| Nucleoporin_FG2 | pfam15967 | Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of ... |
891-1031 | 6.60e-03 | ||||||||||||
Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of chordate nucleoporins. The proteins carry many repeats of the FG sequence motif. Pssm-ID: 435043 [Multi-domain] Cd Length: 586 Bit Score: 40.42 E-value: 6.60e-03
|
||||||||||||||||
| PHA02732 | PHA02732 | hypothetical protein; Provisional |
898-1016 | 6.94e-03 | ||||||||||||
hypothetical protein; Provisional Pssm-ID: 165099 [Multi-domain] Cd Length: 1467 Bit Score: 40.51 E-value: 6.94e-03
|
||||||||||||||||
| Metaviral_G | pfam09595 | Metaviral_G glycoprotein; This is a viral attachment glycoprotein from region G of metaviruses. ... |
880-983 | 7.29e-03 | ||||||||||||
Metaviral_G glycoprotein; This is a viral attachment glycoprotein from region G of metaviruses. It is high in serine and threonine suggesting it is highly glycosylated. Pssm-ID: 462833 [Multi-domain] Cd Length: 183 Bit Score: 38.78 E-value: 7.29e-03
|
||||||||||||||||
| MG2 | pfam01835 | MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
532-582 | 7.55e-03 | ||||||||||||
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4. Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 36.91 E-value: 7.55e-03
|
||||||||||||||||
| PHA03132 | PHA03132 | thymidine kinase; Provisional |
875-1004 | 7.58e-03 | ||||||||||||
thymidine kinase; Provisional Pssm-ID: 222997 [Multi-domain] Cd Length: 580 Bit Score: 40.13 E-value: 7.58e-03
|
||||||||||||||||
| PHA03307 | PHA03307 | transcriptional regulator ICP4; Provisional |
897-1031 | 8.34e-03 | ||||||||||||
transcriptional regulator ICP4; Provisional Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 40.15 E-value: 8.34e-03
|
||||||||||||||||
| PHA03201 | PHA03201 | uracil DNA glycosylase; Provisional |
881-973 | 8.83e-03 | ||||||||||||
uracil DNA glycosylase; Provisional Pssm-ID: 165468 Cd Length: 318 Bit Score: 39.49 E-value: 8.83e-03
|
||||||||||||||||
| PHA03201 | PHA03201 | uracil DNA glycosylase; Provisional |
890-982 | 8.83e-03 | ||||||||||||
uracil DNA glycosylase; Provisional Pssm-ID: 165468 Cd Length: 318 Bit Score: 39.49 E-value: 8.83e-03
|
||||||||||||||||
| PHA03201 | PHA03201 | uracil DNA glycosylase; Provisional |
899-991 | 8.83e-03 | ||||||||||||
uracil DNA glycosylase; Provisional Pssm-ID: 165468 Cd Length: 318 Bit Score: 39.49 E-value: 8.83e-03
|
||||||||||||||||
| PHA03201 | PHA03201 | uracil DNA glycosylase; Provisional |
908-1000 | 8.83e-03 | ||||||||||||
uracil DNA glycosylase; Provisional Pssm-ID: 165468 Cd Length: 318 Bit Score: 39.49 E-value: 8.83e-03
|
||||||||||||||||
| PHA03201 | PHA03201 | uracil DNA glycosylase; Provisional |
917-1009 | 8.83e-03 | ||||||||||||
uracil DNA glycosylase; Provisional Pssm-ID: 165468 Cd Length: 318 Bit Score: 39.49 E-value: 8.83e-03
|
||||||||||||||||
| PHA03201 | PHA03201 | uracil DNA glycosylase; Provisional |
926-1018 | 8.83e-03 | ||||||||||||
uracil DNA glycosylase; Provisional Pssm-ID: 165468 Cd Length: 318 Bit Score: 39.49 E-value: 8.83e-03
|
||||||||||||||||
| DUF3729 | pfam12526 | Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins ... |
873-950 | 9.52e-03 | ||||||||||||
Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins in this family are typically between 145 and 1707 amino acids in length. The family is found in association with pfam01443, pfam01661, pfam05417, pfam01660, pfam00978. There is a single completely conserved residue L that may be functionally important. Pssm-ID: 372164 [Multi-domain] Cd Length: 115 Bit Score: 36.98 E-value: 9.52e-03
|
||||||||||||||||
| Blast search parameters | ||||
|
