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Conserved domains on  [gi|323363004|ref|NP_620805|]
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ribonuclease inhibitor isoform b [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 1-320 6.02e-112

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


:

Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 332.40  E-value: 6.02e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004   1 MSLDIQCEQLSDARWTELLPLIQQYQVVRLDDCGLTEVRCKDIRSAIQANPALTELSLRTNELG--DAGVGLVLQGLQNp 78
Cdd:cd00116    1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTK- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004  79 TCKIQKLSLQNCSLTEAGCGVLPDVLRSlSTLRELHLNDNPLGDEGLKLLCEGLRDPQCRLEKLQLEYCNLTATSCEPLA 158
Cdd:cd00116   80 GCGLQELDLSDNALGPDGCGVLESLLRS-SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 159 SVLRVKPDFKELVLSNNDFHEAGIHTLCQGLKDSaCQLESLKLENCGITSANCKDLCDVVASKASLQELDLGSNKLGNTG 238
Cdd:cd00116  159 KALRANRDLKELNLANNGIGDAGIRALAEGLKAN-CNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAG 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 239 IAALCSGLLLPSCRLRTLWLWDCDVTAEGCKDLCRVLRAKQSLKELSLAGNELKDEGAQLLCESLLEPGCQLESLWVKTC 318
Cdd:cd00116  238 AAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKDD 317


                 ..
gi 323363004 319 SL 320
Cdd:cd00116  318 SF 319
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 277-419 2.38e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 86.77  E-value: 2.38e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 277 AKQSLKELSLAGNELKDEGAQLLCESLlEPGCQLESLWVKTCSLTAASCPHFCSVLTKNRSLFELQMSSNPLGDSGVVEL 356
Cdd:COG5238  178 QNNSVETVYLGCNQIGDEGIEELAEAL-TQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIAL 256

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 323363004 357 CKALGYPDTVLRvLWLGDCDVTDSGCSSLATVLLANRSLRELDLSNNCMGDTGVLQLLESLKQ 419
Cdd:COG5238  257 AEALKNNTTVET-LYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG 318
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 1-320 6.02e-112

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 332.40  E-value: 6.02e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004   1 MSLDIQCEQLSDARWTELLPLIQQYQVVRLDDCGLTEVRCKDIRSAIQANPALTELSLRTNELG--DAGVGLVLQGLQNp 78
Cdd:cd00116    1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTK- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004  79 TCKIQKLSLQNCSLTEAGCGVLPDVLRSlSTLRELHLNDNPLGDEGLKLLCEGLRDPQCRLEKLQLEYCNLTATSCEPLA 158
Cdd:cd00116   80 GCGLQELDLSDNALGPDGCGVLESLLRS-SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 159 SVLRVKPDFKELVLSNNDFHEAGIHTLCQGLKDSaCQLESLKLENCGITSANCKDLCDVVASKASLQELDLGSNKLGNTG 238
Cdd:cd00116  159 KALRANRDLKELNLANNGIGDAGIRALAEGLKAN-CNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAG 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 239 IAALCSGLLLPSCRLRTLWLWDCDVTAEGCKDLCRVLRAKQSLKELSLAGNELKDEGAQLLCESLLEPGCQLESLWVKTC 318
Cdd:cd00116  238 AAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKDD 317


                 ..
gi 323363004 319 SL 320
Cdd:cd00116  318 SF 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 223-418 4.81e-25

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 106.80  E-value: 4.81e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 223 SLQELDLGSNKLGNTGIAALCSGLLLPScRLRTLWLWDCDVTAEGCKDLCRVLRAKQSLKELSLAGNELKDEGAQLLCES 302
Cdd:COG5238  181 SVETVYLGCNQIGDEGIEELAEALTQNT-TVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEA 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 303 LlEPGCQLESLWVKTCSLTAASCPHFCSVLTKNRSLFELQMSSNPLGDSGVVELCKALGYPDTvLRVLWLGDCDVTDSGC 382
Cdd:COG5238  260 L-KNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKT-LHTLNLAYNGIGAQGA 337

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 323363004 383 SSLATVLLANRSLRELDLSNNCMGDTGVLQLLESLK 418
Cdd:COG5238  338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLE 373
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 277-419 2.38e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 86.77  E-value: 2.38e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 277 AKQSLKELSLAGNELKDEGAQLLCESLlEPGCQLESLWVKTCSLTAASCPHFCSVLTKNRSLFELQMSSNPLGDSGVVEL 356
Cdd:COG5238  178 QNNSVETVYLGCNQIGDEGIEELAEAL-TQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIAL 256

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 323363004 357 CKALGYPDTVLRvLWLGDCDVTDSGCSSLATVLLANRSLRELDLSNNCMGDTGVLQLLESLKQ 419
Cdd:COG5238  257 AEALKNNTTVET-LYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG 318
LRR_RI_capping pfam18779
Capping Ribonuclease inhibitor Leucine Rich Repeat; Leucine-rich repeats are composed of a ...
 1-30 2.94e-10

Capping Ribonuclease inhibitor Leucine Rich Repeat; Leucine-rich repeats are composed of a beta-alpha unit. This repeat unit is found as capping unit (N- or C- terminal of the repeat region) of Ribonuclease Inhibitors.


Pssm-ID: 436731  Cd Length: 30  Bit Score: 54.81  E-value: 2.94e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 323363004    1 MSLDIQCEQLSDARWTELLPLIQQYQVVRL 30
Cdd:pfam18779   1 MDLDIQCEELSDSRWTELLPSMQQCKVVRL 30
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 282-429 1.98e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 58.91  E-value: 1.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 282 KELSLAGNELKDEGAQLLCESLLepgcQLESLWVKTCSLTAASCPHFCSVLTKNRSLFELQMSSNPLGDSGVVELCKALG 361
Cdd:cd00116    1 LQLSLKGELLKTERATELLPKLL----CLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPRGLQSLLQG 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 323363004 362 YPDTV-LRVLWLGDCDVTDSGCSSLATvLLANRSLRELDLSNNCMGDTGVLQLLESLKQPSCALQQLVL 429
Cdd:cd00116   77 LTKGCgLQELDLSDNALGPDGCGVLES-LLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVL 144
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
107-134 1.58e-05

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 41.62  E-value: 1.58e-05
                           10        20
                   ....*....|....*....|....*...
gi 323363004   107 LSTLRELHLNDNPLGDEGLKLLCEGLRD 134
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
392-419 3.86e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 37.39  E-value: 3.86e-04
                           10        20
                   ....*....|....*....|....*...
gi 323363004   392 NRSLRELDLSNNCMGDTGVLQLLESLKQ 419
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 1-320 6.02e-112

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 332.40  E-value: 6.02e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004   1 MSLDIQCEQLSDARWTELLPLIQQYQVVRLDDCGLTEVRCKDIRSAIQANPALTELSLRTNELG--DAGVGLVLQGLQNp 78
Cdd:cd00116    1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTK- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004  79 TCKIQKLSLQNCSLTEAGCGVLPDVLRSlSTLRELHLNDNPLGDEGLKLLCEGLRDPQCRLEKLQLEYCNLTATSCEPLA 158
Cdd:cd00116   80 GCGLQELDLSDNALGPDGCGVLESLLRS-SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 159 SVLRVKPDFKELVLSNNDFHEAGIHTLCQGLKDSaCQLESLKLENCGITSANCKDLCDVVASKASLQELDLGSNKLGNTG 238
Cdd:cd00116  159 KALRANRDLKELNLANNGIGDAGIRALAEGLKAN-CNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAG 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 239 IAALCSGLLLPSCRLRTLWLWDCDVTAEGCKDLCRVLRAKQSLKELSLAGNELKDEGAQLLCESLLEPGCQLESLWVKTC 318
Cdd:cd00116  238 AAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKDD 317


                 ..
gi 323363004 319 SL 320
Cdd:cd00116  318 SF 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 223-418 4.81e-25

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 106.80  E-value: 4.81e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 223 SLQELDLGSNKLGNTGIAALCSGLLLPScRLRTLWLWDCDVTAEGCKDLCRVLRAKQSLKELSLAGNELKDEGAQLLCES 302
Cdd:COG5238  181 SVETVYLGCNQIGDEGIEELAEALTQNT-TVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEA 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 303 LlEPGCQLESLWVKTCSLTAASCPHFCSVLTKNRSLFELQMSSNPLGDSGVVELCKALGYPDTvLRVLWLGDCDVTDSGC 382
Cdd:COG5238  260 L-KNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKT-LHTLNLAYNGIGAQGA 337

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 323363004 383 SSLATVLLANRSLRELDLSNNCMGDTGVLQLLESLK 418
Cdd:COG5238  338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLE 373
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 80-418 1.90e-20

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 93.32  E-value: 1.90e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004  80 CKIQKLSLQNcSLTEAGCGVLPDVLRSLSTLRELHLNDNPLGDEGLKLLCEGLRDPQCRLEKLQLEYCNLTATSCEPLAS 159
Cdd:COG5238  124 AKTLEDSLIL-YLALPRRINLIQVLKDPLGGNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAE 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 160 VLRVKPDFKELVLSNNDFHEAGIHTLCQGLKDSAcQLESLKLENCGITSANCKDLCDVVASKASLQELDLGSNKLGNTGI 239
Cdd:COG5238  203 ALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNK-SLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGA 281

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 240 AALCSGLLLPScRLRTLWLWDCDVTAEGCKDLCRVLRAKQSLKELSLAGNELKDEGAQLLCESllepgcqleslwvktcs 319
Cdd:COG5238  282 IALAKALQGNT-TLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKA----------------- 343

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 320 ltaascphfcsvLTKNRSLFELQMSSNPLGDSGVVELCKALGyPDTVLRVLWLGDCDVTDSGCSSLATVLLANRsLRELD 399
Cdd:COG5238  344 ------------LQENTTLHSLDLSDNQIGDEGAIALAKYLE-GNTTLRELNLGKNNIGKQGAEALIDALQTNR-LHTLI 409

                        330
                 ....*....|....*....
gi 323363004 400 LSNNCMGDTGVLQLLESLK 418
Cdd:COG5238  410 LDGNLIGAEAQQRLEQLLE 428
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 56-360 3.59e-20

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 92.55  E-value: 3.59e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004  56 LSLRTNELGDAGVGLVLQGLQNPTckIQKLSLQNCSLTEAGCGVLPDVLRSLSTLRELHLNDNPLGDEGLkllceglrdp 135
Cdd:COG5238  158 LLGLAARLGLLAAISMAKALQNNS--VETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGA---------- 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 136 qcrleklqleycnltatscEPLASVLRVKPDFKELVLSNNDFHEAGIHTLCQGLKDSAcQLESLKLENCGITSANCKDLC 215
Cdd:COG5238  226 -------------------EILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNT-TVETLYLSGNQIGAEGAIALA 285

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 216 DVVASKASLQELDLGSNKLGNTGIAALCSGlLLPSCRLRTLWLWDCDVTAEGCKDLCRVLRAKQSLKELSLAGNELKDEG 295
Cdd:COG5238  286 KALQGNTTLTSLDLSVNRIGDEGAIALAEG-LQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEG 364

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 323363004 296 AQLLCESLLEpgcqleslwvktcsltaascphfcsvltkNRSLFELQMSSNPLGDSGVVELCKAL 360
Cdd:COG5238  365 AIALAKYLEG-----------------------------NTTLRELNLGKNNIGKQGAEALIDAL 400
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 23-266 8.40e-20

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 91.39  E-value: 8.40e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004  23 QQYQVVRLDDCGLTEVRCKDIRSAIQANPALTELSLRTNELGDAGVGLVLQGLQNPTcKIQKLSLQNCSLTEAGCGVLPD 102
Cdd:COG5238  180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNK-SLTTLDLSNNQIGDEGVIALAE 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 103 VLRSLSTLRELHLNDNPLGDEGLKLLCEGLRDPQcRLEKLQLEYCNLTATSCEPLASVLRVKPDFKELVLSNNDFHEAGI 182
Cdd:COG5238  259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQGNT-TLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGA 337

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 183 HTLCQGLKDSAcQLESLKLENCGITSANCKDLCDVVASKASLQELDLGSNKLGNTGIAALCSGLLLPscRLRTLWLWDCD 262
Cdd:COG5238  338 IALAKALQENT-TLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN--RLHTLILDGNL 414


                 ....
gi 323363004 263 VTAE 266
Cdd:COG5238  415 IGAE 418
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 277-419 2.38e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 86.77  E-value: 2.38e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 277 AKQSLKELSLAGNELKDEGAQLLCESLlEPGCQLESLWVKTCSLTAASCPHFCSVLTKNRSLFELQMSSNPLGDSGVVEL 356
Cdd:COG5238  178 QNNSVETVYLGCNQIGDEGIEELAEAL-TQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIAL 256

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 323363004 357 CKALGYPDTVLRvLWLGDCDVTDSGCSSLATVLLANRSLRELDLSNNCMGDTGVLQLLESLKQ 419
Cdd:COG5238  257 AEALKNNTTVET-LYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG 318
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 327-421 7.26e-13

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 70.20  E-value: 7.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 327 HFCSVLTKNRSLFELQMSSNPLGDSGVVELCKALGYPDTVlRVLWLGDCDVTDSGCSSLATVLLANRSLRELDLSNNCMG 406
Cdd:COG5238  171 ISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTV-TTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIG 249

                         90
                 ....*....|....*
gi 323363004 407 DTGVLQLLESLKQPS 421
Cdd:COG5238  250 DEGVIALAEALKNNT 264
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 2-190 4.07e-11

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 64.81  E-value: 4.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004   2 SLDIQCEQLSDARWTELLP-LIQQYQVVRLDDCG--LTEVRCKDIRSAIQANPALTELSLRTNELGDAGVGLVLQGLQNp 78
Cdd:COG5238  240 TLDLSNNQIGDEGVIALAEaLKNNTTVETLYLSGnqIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG- 318

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004  79 TCKIQKLSLQNCSLTEAGCGVLPDVLRSLSTLRELHLNDNPLGDEGLKLLCEGLRDPQcRLEKLQLEYCNLTATSCEPLA 158
Cdd:COG5238  319 NKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNT-TLRELNLGKNNIGKQGAEALI 397

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 323363004 159 SVLrVKPDFKELVLSNNDFH---EAGIHTLCQGLK 190
Cdd:COG5238  398 DAL-QTNRLHTLILDGNLIGaeaQQRLEQLLERIK 431
LRR_RI_capping pfam18779
Capping Ribonuclease inhibitor Leucine Rich Repeat; Leucine-rich repeats are composed of a ...
 1-30 2.94e-10

Capping Ribonuclease inhibitor Leucine Rich Repeat; Leucine-rich repeats are composed of a beta-alpha unit. This repeat unit is found as capping unit (N- or C- terminal of the repeat region) of Ribonuclease Inhibitors.


Pssm-ID: 436731  Cd Length: 30  Bit Score: 54.81  E-value: 2.94e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 323363004    1 MSLDIQCEQLSDARWTELLPLIQQYQVVRL 30
Cdd:pfam18779   1 MDLDIQCEELSDSRWTELLPSMQQCKVVRL 30
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 282-429 1.98e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 58.91  E-value: 1.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 282 KELSLAGNELKDEGAQLLCESLLepgcQLESLWVKTCSLTAASCPHFCSVLTKNRSLFELQMSSNPLGDSGVVELCKALG 361
Cdd:cd00116    1 LQLSLKGELLKTERATELLPKLL----CLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPRGLQSLLQG 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 323363004 362 YPDTV-LRVLWLGDCDVTDSGCSSLATvLLANRSLRELDLSNNCMGDTGVLQLLESLKQPSCALQQLVL 429
Cdd:cd00116   77 LTKGCgLQELDLSDNALGPDGCGVLES-LLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVL 144
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
41-250 1.76e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.93  E-value: 1.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004  41 KDIRSAIQANPALTELSLRTNELGDagVGLVLQGLQNptckIQKLSLQNCSLTEagcgvLPDVLRSLSTLRELHLNDNPL 120
Cdd:COG4886  126 TDLPEELANLTNLKELDLSNNQLTD--LPEPLGNLTN----LKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQI 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 121 GDEGLKLlcEGLRdpqcRLEKLQLEYCNLTAtscepLASVLRVKPDFKELVLSNNDFHEagIHTLCQgLKdsacQLESLK 200
Cdd:COG4886  195 TDLPEPL--GNLT----NLEELDLSGNQLTD-----LPEPLANLTNLETLDLSNNQLTD--LPELGN-LT----NLEELD 256

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 323363004 201 LENCGITSAnckdlcDVVASKASLQELDLGSNKLGNTGIAALCSGLLLPS 250
Cdd:COG4886  257 LSNNQLTDL------PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
107-134 1.58e-05

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 41.62  E-value: 1.58e-05
                           10        20
                   ....*....|....*....|....*...
gi 323363004   107 LSTLRELHLNDNPLGDEGLKLLCEGLRD 134
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-236 4.26e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.69  E-value: 4.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004   2 SLDIQCEQLSDarWTELLPLIQQYQVVRLDDCGLTevrckDIRSAIQANPALTELSLRTNELGDagVGLVLQGLQNptck 81
Cdd:COG4886  117 SLDLSGNQLTD--LPEELANLTNLKELDLSNNQLT-----DLPEPLGNLTNLKSLDLSNNQLTD--LPEELGNLTN---- 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004  82 IQKLSLQNCSLTEagcgvLPDVLRSLSTLRELHLNDNPLGDEGLKLlcEGLRdpqcRLEKLQLEYCNLTatSCEPLASVl 161
Cdd:COG4886  184 LKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTDLPEPL--ANLT----NLETLDLSNNQLT--DLPELGNL- 249

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 323363004 162 rvkPDFKELVLSNNDFheagihtlcQGLKDSAC--QLESLKLENCGITSANCKDLCDVVASKASLQELDLGSNKLGN 236
Cdd:COG4886  250 ---TNLEELDLSNNQL---------TDLPPLANltNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
195-432 2.85e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.00  E-value: 2.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 195 QLESLKLENCGITsanckDLCDVVASKASLQELDLGSNKLgnTGIAALCSGLLlpscRLRTLWLWDCDVTaegckDLCRV 274
Cdd:COG4886  114 NLESLDLSGNQLT-----DLPEELANLTNLKELDLSNNQL--TDLPEPLGNLT----NLKSLDLSNNQLT-----DLPEE 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323363004 275 LRAKQSLKELSLAGNELKDEGAQLlcESLlepgCQLESLWVKTCSLTAASCPhfcsvLTKNRSLFELQMSSNPLGDsgVV 354
Cdd:COG4886  178 LGNLTNLKELDLSNNQITDLPEPL--GNL----TNLEELDLSGNQLTDLPEP-----LANLTNLETLDLSNNQLTD--LP 244

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 323363004 355 ELCKAlgypdTVLRVLWLGDCDVTDsgcsslATVLLANRSLRELDLSNNCMGDTGVLQLLESLKQPSCALQQLVLYDI 432
Cdd:COG4886  245 ELGNL-----TNLEELDLSNNQLTD------LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
392-419 3.86e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 37.39  E-value: 3.86e-04
                           10        20
                   ....*....|....*....|....*...
gi 323363004   392 NRSLRELDLSNNCMGDTGVLQLLESLKQ 419
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
335-360 1.82e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 35.46  E-value: 1.82e-03
                           10        20
                   ....*....|....*....|....*.
gi 323363004   335 NRSLFELQMSSNPLGDSGVVELCKAL 360
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEAL 26
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
250-277 2.42e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 35.46  E-value: 2.42e-03
                           10        20
                   ....*....|....*....|....*...
gi 323363004   250 SCRLRTLWLWDCDVTAEGCKDLCRVLRA 277
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
164-191 5.58e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 34.31  E-value: 5.58e-03
                           10        20
                   ....*....|....*....|....*...
gi 323363004   164 KPDFKELVLSNNDFHEAGIHTLCQGLKD 191
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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