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Conserved domains on  [gi|20270389|ref|NP_620175|]
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HIG1 domain family member 2A, mitochondrial [Homo sapiens]

Protein Classification

HIG1 domain-containing protein( domain architecture ID 10519045)

HIG1 domain-containing protein similar to mitochondrial respiratory supercomplex factor 1, a cytochrome c oxidase subunit which plays a role in the assembly of respiratory supercomplexes

CATH:  6.10.140.1320
Gene Ontology:  GO:0016020|GO:0097250|GO:0005739
SCOP:  4004933

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HIG_1_N pfam04588
Hypoxia induced protein conserved region; This family is found in proteins thought to be ...
 45-96 1.45e-26

Hypoxia induced protein conserved region; This family is found in proteins thought to be involved in the response to hypoxia. Family members mostly come from diverse eukaryotic organizms however eubacterial members have been identified. This region is found at the N-terminus of the member proteins which are predicted to be transmembrane.


:

Pssm-ID: 461361  Cd Length: 52  Bit Score: 92.54  E-value: 1.45e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 20270389    45 ENPVVPIGCLATAAALTYGLYSFHRGNSQRSQLMMRTRIAAQGFTVAAILLG 96
Cdd:pfam04588   1 ENPLVPIGCLATAGALVYGLYSMRRGNSGTSQKLMRARVAAQGFTVAALVGG 52
 
Name Accession Description Interval E-value
HIG_1_N pfam04588
Hypoxia induced protein conserved region; This family is found in proteins thought to be ...
 45-96 1.45e-26

Hypoxia induced protein conserved region; This family is found in proteins thought to be involved in the response to hypoxia. Family members mostly come from diverse eukaryotic organizms however eubacterial members have been identified. This region is found at the N-terminus of the member proteins which are predicted to be transmembrane.


Pssm-ID: 461361  Cd Length: 52  Bit Score: 92.54  E-value: 1.45e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 20270389    45 ENPVVPIGCLATAAALTYGLYSFHRGNSQRSQLMMRTRIAAQGFTVAAILLG 96
Cdd:pfam04588   1 ENPLVPIGCLATAGALVYGLYSMRRGNSGTSQKLMRARVAAQGFTVAALVGG 52
twin_helix NF033233
twin transmembrane helix small protein; Members of the seed alignment for this family are ...
 48-98 8.51e-09

twin transmembrane helix small protein; Members of the seed alignment for this family are small (average length 68 residues), strictly bacterial, and extremely hydrophobic. Pfam model PF04588 (HIG_1_N) includes both eukaryotic proteins, including a protein from the fish Gillichthys mirabilis, and the members of this family. Similarity between those eukaryotic proteins and the members o this model may represent convergent evolution related to the similar composition of their transmembrane alpha-helical regions, rather than a common origin or common function.


Pssm-ID: 380228  Cd Length: 58  Bit Score: 47.42  E-value: 8.51e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 20270389   48 VVPIGCLATAAALTYGLYSFHR-GNSQRSQLMMRTRIAAQGFTVAAILLGLA 98
Cdd:NF033233   3 LIVIALLAVLASLGSGLFFLMRgGDSNRSNKLMRWRVGLQAVAILLILLALY 54
 
Name Accession Description Interval E-value
HIG_1_N pfam04588
Hypoxia induced protein conserved region; This family is found in proteins thought to be ...
 45-96 1.45e-26

Hypoxia induced protein conserved region; This family is found in proteins thought to be involved in the response to hypoxia. Family members mostly come from diverse eukaryotic organizms however eubacterial members have been identified. This region is found at the N-terminus of the member proteins which are predicted to be transmembrane.


Pssm-ID: 461361  Cd Length: 52  Bit Score: 92.54  E-value: 1.45e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 20270389    45 ENPVVPIGCLATAAALTYGLYSFHRGNSQRSQLMMRTRIAAQGFTVAAILLG 96
Cdd:pfam04588   1 ENPLVPIGCLATAGALVYGLYSMRRGNSGTSQKLMRARVAAQGFTVAALVGG 52
twin_helix NF033233
twin transmembrane helix small protein; Members of the seed alignment for this family are ...
 48-98 8.51e-09

twin transmembrane helix small protein; Members of the seed alignment for this family are small (average length 68 residues), strictly bacterial, and extremely hydrophobic. Pfam model PF04588 (HIG_1_N) includes both eukaryotic proteins, including a protein from the fish Gillichthys mirabilis, and the members of this family. Similarity between those eukaryotic proteins and the members o this model may represent convergent evolution related to the similar composition of their transmembrane alpha-helical regions, rather than a common origin or common function.


Pssm-ID: 380228  Cd Length: 58  Bit Score: 47.42  E-value: 8.51e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 20270389   48 VVPIGCLATAAALTYGLYSFHR-GNSQRSQLMMRTRIAAQGFTVAAILLGLA 98
Cdd:NF033233   3 LIVIALLAVLASLGSGLFFLMRgGDSNRSNKLMRWRVGLQAVAILLILLALY 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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