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Conserved domains on  [gi|19924149|ref|NP_612564|]
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toll-like receptor 4 isoform A precursor [Homo sapiens]

Protein Classification

toll-like receptor( domain architecture ID 13320966)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
674-815 1.95e-34

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 128.21  E-value: 1.95e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149    674 YDAFVIYSSQDedWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIiHEGFHKSRKVIVVVSQHFIQSRWCIFEYEI 753
Cdd:smart00255   2 YDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEI-DEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19924149    754 AQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNtYLEWEDSVLGRhiFWRRLRKAL 815
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKN-YLKWPEDEKEQ--FWKKALYAV 137
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
290-581 5.01e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 5.01e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 290 LAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSE 369
Cdd:COG4886  13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 370 VDLPSLEFLDLSRNGLSFKgccsqsdfgTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEfsVFLSLRNL 449
Cdd:COG4886  93 GDLTNLTELDLSGNEELSN---------LTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 450 IYLDISHTHTRVAFNGIFNgLSSLEVLKMAGNSFQEnfLPDIFTELRNLTFLDLSQCQLEQLsPTAFNSLSSLQVLNMSH 529
Cdd:COG4886 162 KSLDLSNNQLTDLPEELGN-LTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSN 237

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 19924149 530 NNFFSLDTFpyKCLNSLQVLDYSLNHIMT-SKKQELQhfpsSLAFLNLTQNDF 581
Cdd:COG4886 238 NQLTDLPEL--GNLTNLEELDLSNNQLTDlPPLANLT----NLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
57-114 2.58e-08

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.58e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 19924149    57 KNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPI 114
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 76-190 1.15e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 53.25  E-value: 1.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  76 SFPELQVLDLSRCEIQTIEDgaYQSLSHLSTLILTGNPIQSLalGAFSGLSSLQKL------VAVETNLASLENF----- 144
Cdd:cd21340  22 LCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLylggnrISVVEGLENLTNLeelhi 97

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19924149 145 -----PIGH------------LKTLKELNVAHNLIQSfklPEYFSNLTNLEHLDLSSNKIQSI 190
Cdd:cd21340  98 enqrlPPGEkltfdprslaalSNSLRVLNISGNNIDS---LEPLAPLRNLEQLDASNNQISDL 157
LRRCT smart00082
Leucine rich repeat C-terminal domain;
579-625 9.95e-07

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.27  E-value: 9.95e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 19924149    579 NDFACTCEHQSFLQWIKDQRQLLvEVERMECATPSDKQGmPVLSLNI 625
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ-DPVDLRCASPSSLRG-PLLELLH 45
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
674-815 1.95e-34

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 128.21  E-value: 1.95e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149    674 YDAFVIYSSQDedWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIiHEGFHKSRKVIVVVSQHFIQSRWCIFEYEI 753
Cdd:smart00255   2 YDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEI-DEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19924149    754 AQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNtYLEWEDSVLGRhiFWRRLRKAL 815
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKN-YLKWPEDEKEQ--FWKKALYAV 137
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 677-816 9.61e-33

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 124.40  E-value: 9.61e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149   677 FVIYSS----QDEDWVRNELVKNLeeGVPPFQLCLHYRDFIPGVAIAANIiHEGFHKSRKVIVVVSQHFIQSRWCIFEYE 752
Cdd:pfam01582   1 YDVFLSfrgsDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPEL-LSAIEKSRRSVVVLSPNYASSGWCLDELV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149   753 IAQTWQfLSSRAGIIFIVLQKVEK-------TLLRQQVELYRLLSRNTYLEWE------------DSVLGRHIFWRRLRK 813
Cdd:pfam01582  78 KILECA-LDLGQKVIPIFYEVDPSdvrkqtgSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIAY 156


                  ...
gi 19924149   814 ALL 816
Cdd:pfam01582 157 DIS 159
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
290-581 5.01e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 5.01e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 290 LAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSE 369
Cdd:COG4886  13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 370 VDLPSLEFLDLSRNGLSFKgccsqsdfgTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEfsVFLSLRNL 449
Cdd:COG4886  93 GDLTNLTELDLSGNEELSN---------LTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 450 IYLDISHTHTRVAFNGIFNgLSSLEVLKMAGNSFQEnfLPDIFTELRNLTFLDLSQCQLEQLsPTAFNSLSSLQVLNMSH 529
Cdd:COG4886 162 KSLDLSNNQLTDLPEELGN-LTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSN 237

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 19924149 530 NNFFSLDTFpyKCLNSLQVLDYSLNHIMT-SKKQELQhfpsSLAFLNLTQNDF 581
Cdd:COG4886 238 NQLTDLPEL--GNLTNLEELDLSNNQLTDlPPLANLT----NLKTLDLSNNQL 284
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 47-532 6.09e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 76.04  E-value: 6.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149   47 KIPDN---LPFSTKNLDLSFNPLRhlGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFS 123
Cdd:PLN00113 108 PIPDDiftTSSSLRYLNLSNNNFT--GSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  124 GLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIqSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPL 203
Cdd:PLN00113 186 NLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL-SGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQY 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  204 LNLSLDLSLNPmnfIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQgLAGLEVHRLvlgeFRNegnleKFDKSALEGLCNL 283
Cdd:PLN00113 265 LFLYQNKLSGP---IPPSIFSLQKLISLDLSDNSLSGEIPELVIQ-LQNLEILHL----FSN-----NFTGKIPVALTSL 331

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  284 TieefRLAYLDYYLDDI-------IDLFNCLT--NVSSFSLVSVTIERVKDFSYNFgwQHLELVNCKFGQFPTL--KLKS 352
Cdd:PLN00113 332 P----RLQVLQLWSNKFsgeipknLGKHNNLTvlDLSTNNLTGEIPEGLCSSGNLF--KLILFSNSLEGEIPKSlgACRS 405

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  353 LKRLTFTSNKGGNAFSE--VDLPSLEFLDLSRNGLSfkGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQ 430
Cdd:PLN00113 406 LRRVRLQDNSFSGELPSefTKLPLVYFLDISNNNLQ--GRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLS 483

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  431 HSNLKQMSEFSvFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENfLPDIFTELRNLTFLDLSQCQLEQ 510
Cdd:PLN00113 484 RNQFSGAVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQ-IPASFSEMPVLSQLDLSQNQLSG 561

                        490       500
                 ....*....|....*....|..
gi 19924149  511 LSPTAFNSLSSLQVLNMSHNNF 532
Cdd:PLN00113 562 EIPKNLGNVESLVQVNISHNHL 583
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 399-561 3.01e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.96  E-value: 3.01e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 399 TSLKYLDLsFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSvflSLRNLIYLDISHTHTRVAFNgiFNGLSSLEVLKM 478
Cdd:cd21340  24 KNLKVLYL-YDNKITKIENLEFLTNLTHLYLQNNQIEKIENLE---NLVNLKKLYLGGNRISVVEG--LENLTNLEELHI 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 479 AGNSFQEN----FLPD-IFTELRNLTFLDLSQCQLEQLSPtaFNSLSSLQVLNMSHNNFFSLD--TFPYKCLNSLQVLDY 551
Cdd:cd21340  98 ENQRLPPGekltFDPRsLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDL 175

                       170
                ....*....|
gi 19924149 552 SLNHIMTSKK 561
Cdd:cd21340 176 TGNPVCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
57-114 2.58e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.58e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 19924149    57 KNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPI 114
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 76-190 1.15e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.25  E-value: 1.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  76 SFPELQVLDLSRCEIQTIEDgaYQSLSHLSTLILTGNPIQSLalGAFSGLSSLQKL------VAVETNLASLENF----- 144
Cdd:cd21340  22 LCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLylggnrISVVEGLENLTNLeelhi 97

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19924149 145 -----PIGH------------LKTLKELNVAHNLIQSfklPEYFSNLTNLEHLDLSSNKIQSI 190
Cdd:cd21340  98 enqrlPPGEkltfdprslaalSNSLRVLNISGNNIDS---LEPLAPLRNLEQLDASNNQISDL 157
LRR_8 pfam13855
Leucine rich repeat;
102-187 4.02e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 4.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149   102 SHLSTLILTGNPIQSLALGAFSGLSSLqklvavetnlaslenfpighlktlKELNVAHNLIQSFkLPEYFSNLTNLEHLD 181
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNL------------------------KVLDLSNNLLTTL-SPGAFSGLPSLRYLD 55


                  ....*.
gi 19924149   182 LSSNKI 187
Cdd:pfam13855  56 LSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
579-625 9.95e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.27  E-value: 9.95e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 19924149    579 NDFACTCEHQSFLQWIKDQRQLLvEVERMECATPSDKQGmPVLSLNI 625
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ-DPVDLRCASPSSLRG-PLLELLH 45
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 349-556 8.17e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 8.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  349 KLKSLKRLTFTSNK--GGNAFSEVDLPSLEFLDLSRNGLSfkGCCSQSDFGTTSLKYLDLSFNGVI-TMSSNFLGLEQLE 425
Cdd:PLN00113 186 NLTSLEFLTLASNQlvGQIPRELGQMKSLKWIYLGYNNLS--GEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQ 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  426 HLDFQHSNLKQMSEFSVFlSLRNLIYLDISHthtrvafngifNGLSSLevlkmagnsfqenfLPDIFTELRNLTFLDLSQ 505
Cdd:PLN00113 264 YLFLYQNKLSGPIPPSIF-SLQKLISLDLSD-----------NSLSGE--------------IPELVIQLQNLEILHLFS 317

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 19924149  506 CQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHI 556
Cdd:PLN00113 318 NNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNL 368
LRR_8 pfam13855
Leucine rich repeat;
471-532 1.19e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 1.19e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19924149   471 SSLEVLKMAGNSFQeNFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNF 532
Cdd:pfam13855   1 PNLRSLDLSNNRLT-SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 55-187 1.82e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.70  E-value: 1.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  55 STKNLDLSFNPLRHLGSYSFFS----FPELQVLDLSRCEIQtiEDG------AYQSLSHLSTLILTGNPIQSlalgafSG 124
Cdd:COG5238 209 TVTTLWLKRNPIGDEGAEILAEalkgNKSLTTLDLSNNQIG--DEGvialaeALKNNTTVETLYLSGNQIGA------EG 280

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 125 LSSLQKLVAVETNLASL---ENfPIG------------HLKTLKELNVAHNLI--QSFK-LPEYFSNLTNLEHLDLSSNK 186
Cdd:COG5238 281 AIALAKALQGNTTLTSLdlsVN-RIGdegaialaeglqGNKTLHTLNLAYNGIgaQGAIaLAKALQENTTLHSLDLSDNQ 359


                .
gi 19924149 187 I 187
Cdd:COG5238 360 I 360
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
674-815 1.95e-34

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 128.21  E-value: 1.95e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149    674 YDAFVIYSSQDedWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIiHEGFHKSRKVIVVVSQHFIQSRWCIFEYEI 753
Cdd:smart00255   2 YDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEI-DEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19924149    754 AQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNtYLEWEDSVLGRhiFWRRLRKAL 815
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKN-YLKWPEDEKEQ--FWKKALYAV 137
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 677-816 9.61e-33

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 124.40  E-value: 9.61e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149   677 FVIYSS----QDEDWVRNELVKNLeeGVPPFQLCLHYRDFIPGVAIAANIiHEGFHKSRKVIVVVSQHFIQSRWCIFEYE 752
Cdd:pfam01582   1 YDVFLSfrgsDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPEL-LSAIEKSRRSVVVLSPNYASSGWCLDELV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149   753 IAQTWQfLSSRAGIIFIVLQKVEK-------TLLRQQVELYRLLSRNTYLEWE------------DSVLGRHIFWRRLRK 813
Cdd:pfam01582  78 KILECA-LDLGQKVIPIFYEVDPSdvrkqtgSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIAY 156


                  ...
gi 19924149   814 ALL 816
Cdd:pfam01582 157 DIS 159
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
290-581 5.01e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 5.01e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 290 LAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSE 369
Cdd:COG4886  13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 370 VDLPSLEFLDLSRNGLSFKgccsqsdfgTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEfsVFLSLRNL 449
Cdd:COG4886  93 GDLTNLTELDLSGNEELSN---------LTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 450 IYLDISHTHTRVAFNGIFNgLSSLEVLKMAGNSFQEnfLPDIFTELRNLTFLDLSQCQLEQLsPTAFNSLSSLQVLNMSH 529
Cdd:COG4886 162 KSLDLSNNQLTDLPEELGN-LTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSN 237

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 19924149 530 NNFFSLDTFpyKCLNSLQVLDYSLNHIMT-SKKQELQhfpsSLAFLNLTQNDF 581
Cdd:COG4886 238 NQLTDLPEL--GNLTNLEELDLSNNQLTDlPPLANLT----NLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
333-601 1.37e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 1.37e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 333 QHLELVNCKFGQFPTL--KLKSLKRLTFTSNKGGNAFSEV-DLPSLEFLDLSRNGLSfkgCCSQSDFGTTSLKYLDLSFN 409
Cdd:COG4886 116 ESLDLSGNQLTDLPEElaNLTNLKELDLSNNQLTDLPEPLgNLTNLKSLDLSNNQLT---DLPEELGNLTNLKELDLSNN 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 410 GVITMSSNFLGLEQLEHLDFQHSNLKQMSEfsVFLSLRNLIYLDISHthtrvafNGI-----FNGLSSLEVLKMAGNSFQ 484
Cdd:COG4886 193 QITDLPEPLGNLTNLEELDLSGNQLTDLPE--PLANLTNLETLDLSN-------NQLtdlpeLGNLTNLEELDLSNNQLT 263

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 485 EnfLPDIFtELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQEL 564
Cdd:COG4886 264 D--LPPLA-NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 19924149 565 QHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLL 601
Cdd:COG4886 341 ALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEA 377
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 47-532 6.09e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 76.04  E-value: 6.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149   47 KIPDN---LPFSTKNLDLSFNPLRhlGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFS 123
Cdd:PLN00113 108 PIPDDiftTSSSLRYLNLSNNNFT--GSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  124 GLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIqSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPL 203
Cdd:PLN00113 186 NLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL-SGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQY 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  204 LNLSLDLSLNPmnfIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQgLAGLEVHRLvlgeFRNegnleKFDKSALEGLCNL 283
Cdd:PLN00113 265 LFLYQNKLSGP---IPPSIFSLQKLISLDLSDNSLSGEIPELVIQ-LQNLEILHL----FSN-----NFTGKIPVALTSL 331

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  284 TieefRLAYLDYYLDDI-------IDLFNCLT--NVSSFSLVSVTIERVKDFSYNFgwQHLELVNCKFGQFPTL--KLKS 352
Cdd:PLN00113 332 P----RLQVLQLWSNKFsgeipknLGKHNNLTvlDLSTNNLTGEIPEGLCSSGNLF--KLILFSNSLEGEIPKSlgACRS 405

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  353 LKRLTFTSNKGGNAFSE--VDLPSLEFLDLSRNGLSfkGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQ 430
Cdd:PLN00113 406 LRRVRLQDNSFSGELPSefTKLPLVYFLDISNNNLQ--GRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLS 483

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  431 HSNLKQMSEFSvFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENfLPDIFTELRNLTFLDLSQCQLEQ 510
Cdd:PLN00113 484 RNQFSGAVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQ-IPASFSEMPVLSQLDLSQNQLSG 561

                        490       500
                 ....*....|....*....|..
gi 19924149  511 LSPTAFNSLSSLQVLNMSHNNF 532
Cdd:PLN00113 562 EIPKNLGNVESLVQVNISHNHL 583
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 677-772 5.23e-13

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 66.18  E-value: 5.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149   677 FVIYSSQDEDWVRnELVKNLEE-GVPPFqlcLHYRDFIPGVAIAANIiHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAq 755
Cdd:pfam13676   2 FISYAGEDRAWAE-WLADALEAaGYRVW---LDRWDIRPGDDWVEEI-EEAIENSDRVLVVLSPNYLESPWCRAEWEAA- 75

                          90
                  ....*....|....*..
gi 19924149   756 tWQFLSSRAGIIFIVLQ 772
Cdd:pfam13676  76 -LADPEGRKRLIPVRLE 91
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 399-561 3.01e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.96  E-value: 3.01e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 399 TSLKYLDLsFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSvflSLRNLIYLDISHTHTRVAFNgiFNGLSSLEVLKM 478
Cdd:cd21340  24 KNLKVLYL-YDNKITKIENLEFLTNLTHLYLQNNQIEKIENLE---NLVNLKKLYLGGNRISVVEG--LENLTNLEELHI 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 479 AGNSFQEN----FLPD-IFTELRNLTFLDLSQCQLEQLSPtaFNSLSSLQVLNMSHNNFFSLD--TFPYKCLNSLQVLDY 551
Cdd:cd21340  98 ENQRLPPGekltFDPRsLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDL 175

                       170
                ....*....|
gi 19924149 552 SLNHIMTSKK 561
Cdd:cd21340 176 TGNPVCKKPK 185
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-503 1.79e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.72  E-value: 1.79e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  69 LGSYSFFSFPELQVLDLSRCEiqtiedgAYQSLSHLSTLILTGNPIQSLALgAFSGLSSLQKLVAVETNLASLENfPIGH 148
Cdd:COG4886  87 LGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGN 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 149 LKTLKELNVAHNLIQSfkLPEYFSNLTNLEHLDLSSNKIQSIyctdlrvlhqmpllnlsldlslnpmnfiqPGAFKEI-R 227
Cdd:COG4886 158 LTNLKSLDLSNNQLTD--LPEELGNLTNLKELDLSNNQITDL-----------------------------PEPLGNLtN 206

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 228 LHKLTLRNNfdslnvmktciqglaglevhrlvlgefrnegNLEKFDKSaLEGLCNLTieefrlayldyylddiidlfncl 307
Cdd:COG4886 207 LEELDLSGN-------------------------------QLTDLPEP-LANLTNLE----------------------- 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 308 tnvssfslvsvtiervkdfsynfgwqHLELVNCKFGQFPTL-KLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLS 386
Cdd:COG4886 232 --------------------------TLDLSNNQLTDLPELgNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLT 285

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 387 FKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGI 466
Cdd:COG4886 286 DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTL 365

                       410       420       430
                ....*....|....*....|....*....|....*..
gi 19924149 467 FNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDL 503
Cdd:COG4886 366 LLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLL 402
LRR_8 pfam13855
Leucine rich repeat;
57-114 2.58e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.58e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 19924149    57 KNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPI 114
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
78-131 6.75e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 6.75e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 19924149    78 PELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKL 131
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYL 54
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 76-190 1.15e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.25  E-value: 1.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  76 SFPELQVLDLSRCEIQTIEDgaYQSLSHLSTLILTGNPIQSLalGAFSGLSSLQKL------VAVETNLASLENF----- 144
Cdd:cd21340  22 LCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLylggnrISVVEGLENLTNLeelhi 97

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19924149 145 -----PIGH------------LKTLKELNVAHNLIQSfklPEYFSNLTNLEHLDLSSNKIQSI 190
Cdd:cd21340  98 enqrlPPGEkltfdprslaalSNSLRVLNISGNNIDS---LEPLAPLRNLEQLDASNNQISDL 157
LRR_8 pfam13855
Leucine rich repeat;
102-187 4.02e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 4.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149   102 SHLSTLILTGNPIQSLALGAFSGLSSLqklvavetnlaslenfpighlktlKELNVAHNLIQSFkLPEYFSNLTNLEHLD 181
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNL------------------------KVLDLSNNLLTTL-SPGAFSGLPSLRYLD 55


                  ....*.
gi 19924149   182 LSSNKI 187
Cdd:pfam13855  56 LSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 421-579 7.12e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 7.12e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 421 LEQLEHLDFQHSNLKQMSEFSVFLSLRNLiYL---DISH----------THTRVAFNGI-----FNGLSSLEVLKMAGNS 482
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNLSLCKNLKVL-YLydnKITKienlefltnlTHLYLQNNQIekienLENLVNLKKLYLGGNR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 483 FQ--ENflpdiFTELRNLTFLDLSQCQL---EQLS--PTAFNSLS-SLQVLNMSHNNFFSLDtfPYKCLNSLQVLDYSLN 554
Cdd:cd21340  80 ISvvEG-----LENLTNLEELHIENQRLppgEKLTfdPRSLAALSnSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNN 152

                       170       180
                ....*....|....*....|....*..
gi 19924149 555 HI--MTSKKQELQHFPsSLAFLNLTQN 579
Cdd:cd21340 153 QIsdLEELLDLLSSWP-SLRELDLTGN 178
LRRCT smart00082
Leucine rich repeat C-terminal domain;
579-625 9.95e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.27  E-value: 9.95e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 19924149    579 NDFACTCEHQSFLQWIKDQRQLLvEVERMECATPSDKQGmPVLSLNI 625
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ-DPVDLRCASPSSLRG-PLLELLH 45
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 349-556 8.17e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 8.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  349 KLKSLKRLTFTSNK--GGNAFSEVDLPSLEFLDLSRNGLSfkGCCSQSDFGTTSLKYLDLSFNGVI-TMSSNFLGLEQLE 425
Cdd:PLN00113 186 NLTSLEFLTLASNQlvGQIPRELGQMKSLKWIYLGYNNLS--GEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQ 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  426 HLDFQHSNLKQMSEFSVFlSLRNLIYLDISHthtrvafngifNGLSSLevlkmagnsfqenfLPDIFTELRNLTFLDLSQ 505
Cdd:PLN00113 264 YLFLYQNKLSGPIPPSIF-SLQKLISLDLSD-----------NSLSGE--------------IPELVIQLQNLEILHLFS 317

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 19924149  506 CQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHI 556
Cdd:PLN00113 318 NNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNL 368
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 57-627 8.46e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 8.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149   57 KNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQ-TIEDGAYQSLSHLSTLILTGNPIQ-SLALGAFSGLSSLQklvaV 134
Cdd:PLN00113  72 VSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLD----L 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  135 ETNLASLENF-PIGHLKTLKELNVAHNLIQSfKLPEYFSNLTNLEHLDLSSNKIqsiyctdlrvLHQMPLlnlsldlsln 213
Cdd:PLN00113 148 SNNMLSGEIPnDIGSFSSLKVLDLGGNVLVG-KIPNSLTNLTSLEFLTLASNQL----------VGQIPR---------- 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  214 pmnfiQPGAFKEIRLHKLTLrNNFDSlnVMKTCIQGLAGLEVHRLVLGefrnegNLEKFDKSALEGLCNLtieEFRLAYL 293
Cdd:PLN00113 207 -----ELGQMKSLKWIYLGY-NNLSG--EIPYEIGGLTSLNHLDLVYN------NLTGPIPSSLGNLKNL---QYLFLYQ 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  294 DYYLDDIIDLFNCLTNVSSFslvsvtiervkDFSYNFgwqhlelvncKFGQFPTL--KLKSLKRLTFTSNK--GGNAFSE 369
Cdd:PLN00113 270 NKLSGPIPPSIFSLQKLISL-----------DLSDNS----------LSGEIPELviQLQNLEILHLFSNNftGKIPVAL 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  370 VDLPSLEFLDLSRNGLSFKgccSQSDFGT-TSLKYLDLSfngvitmsSNFLGLEQLEHLdFQHSNLKQMSEFSVflSLRN 448
Cdd:PLN00113 329 TSLPRLQVLQLWSNKFSGE---IPKNLGKhNNLTVLDLS--------TNNLTGEIPEGL-CSSGNLFKLILFSN--SLEG 394

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  449 LIYLDIShthtrvafngifnGLSSLEVLKMAGNSFQENfLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMS 528
Cdd:PLN00113 395 EIPKSLG-------------ACRSLRRVRLQDNSFSGE-LPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLA 460

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  529 HNNFFS--LDTFPYKclnSLQVLDYSLNHIMTSKKQELQHFPsSLAFLNLTQNDFacTCEHQSFLQWIKDQRQLLVEVER 606
Cdd:PLN00113 461 RNKFFGglPDSFGSK---RLENLDLSRNQFSGAVPRKLGSLS-ELMQLKLSENKL--SGEIPDELSSCKKLVSLDLSHNQ 534

                        570       580
                 ....*....|....*....|..
gi 19924149  607 MECATPSDKQGMPVLS-LNITC 627
Cdd:PLN00113 535 LSGQIPASFSEMPVLSqLDLSQ 556
LRR_8 pfam13855
Leucine rich repeat;
151-202 3.96e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 3.96e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 19924149   151 TLKELNVAHNLIQSFKlPEYFSNLTNLEHLDLSSNKIQSIyctDLRVLHQMP 202
Cdd:pfam13855   2 NLRSLDLSNNRLTSLD-DGAFKGLSNLKVLDLSNNLLTTL---SPGAFSGLP 49
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 152-456 8.97e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.42  E-value: 8.97e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 152 LKELNVAHNLIQSFKLPEYFSNLT---NLEHLDLSSNKIQSIyctdLRVLHqmpllnlsldlsLNPMNFIqpgafKEIRL 228
Cdd:cd00116  25 LQVLRLEGNTLGEEAAKALASALRpqpSLKELCLSLNETGRI----PRGLQ------------SLLQGLT-----KGCGL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 229 HKLTLRNNfdSLnvmktCIQGLAGLE--VHRLVLGEFRNEGNLEKFDKSAL--EGLCNLT--IEEFRLAYldyylddiid 302
Cdd:cd00116  84 QELDLSDN--AL-----GPDGCGVLEslLRSSSLQELKLNNNGLGDRGLRLlaKGLKDLPpaLEKLVLGR---------- 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 303 lfNCLTNVSSFSLVSVTIE----RVKDFSYN----FGWQHLelvnCK-FGQFPTLKLKSLKRLTFTSnKGGNAFSEV--D 371
Cdd:cd00116 147 --NRLEGASCEALAKALRAnrdlKELNLANNgigdAGIRAL----AEgLKANCNLEVLDLNNNGLTD-EGASALAETlaS 219

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 372 LPSLEFLDLSRNGLSFKGC---CSQSDFGTTSLKYLDLSFN-----GVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSVF 443
Cdd:cd00116 220 LKSLEVLNLGDNNLTDAGAaalASALLSPNISLLTLSLSCNditddGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLA 299

                       330
                ....*....|....*..
gi 19924149 444 LSL----RNLIYLDISH 456
Cdd:cd00116 300 ESLlepgNELESLWVKD 316
LRR_9 pfam14580
Leucine-rich repeat;
41-143 9.81e-05

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 43.98  E-value: 9.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149    41 MELNFYKIP--DNL-----PFSTknLDLSFNPLRHLGSYSFFsfPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNP 113
Cdd:pfam14580  24 LDLRGYKIPiiENLgatldQFDT--IDFSDNEIRKLDGFPLL--RRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNN 99

                          90       100       110
                  ....*....|....*....|....*....|
gi 19924149   114 IQSlaLGAFSGLSSLQKLvaveTNLASLEN 143
Cdd:pfam14580 100 LQE--LGDLDPLASLKKL----TFLSLLRN 123
LRR_8 pfam13855
Leucine rich repeat;
471-532 1.19e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 1.19e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19924149   471 SSLEVLKMAGNSFQeNFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNF 532
Cdd:pfam13855   1 PNLRSLDLSNNRLT-SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 55-195 3.00e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 3.00e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  55 STKNLDLSFNPLRHLGSY------SFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTL---ILTGNPIQSLAL-----G 120
Cdd:cd00116  52 SLKELCLSLNETGRIPRGlqsllqGLTKGCGLQELDLSDNALGPDGCGVLESLLRSSSLqelKLNNNGLGDRGLrllakG 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 121 AFSGLSSLQKLVAVETNLASLENFPIG----HLKTLKELNVAHNLIQSF---KLPEYFSNLTNLEHLDLSSNKIQSIYCT 193
Cdd:cd00116 132 LKDLPPALEKLVLGRNRLEGASCEALAkalrANRDLKELNLANNGIGDAgirALAEGLKANCNLEVLDLNNNGLTDEGAS 211


                ..
gi 19924149 194 DL 195
Cdd:cd00116 212 AL 213
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 372-581 4.78e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.11  E-value: 4.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 372 LPSLEFLDLSRNGLSFKGCCSQSDF-GTTSLKYLDLSFNGvitmssnflgleqlehLDFQHSNLKQMSEFSVFLSLRNLI 450
Cdd:cd00116  80 GCGLQELDLSDNALGPDGCGVLESLlRSSSLQELKLNNNG----------------LGDRGLRLLAKGLKDLPPALEKLV 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 451 --YLDISHTHTRvAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELR---NLTFLDLSQCQLE-----QLSPTaFNSLS 520
Cdd:cd00116 144 lgRNRLEGASCE-ALAKALRANRDLKELNLANNGIGDAGIRALAEGLKancNLEVLDLNNNGLTdegasALAET-LASLK 221

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 521 SLQVLNMSHNNFFS-----LDTFPYKCLNSLQVLDYSLNHIMT----SKKQELQHFPsSLAFLNLTQNDF 581
Cdd:cd00116 222 SLEVLNLGDNNLTDagaaaLASALLSPNISLLTLSLSCNDITDdgakDLAEVLAEKE-SLLELDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
399-458 5.21e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 5.21e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19924149   399 TSLKYLDLSFNGVITMS-SNFLGLEQLEHLDFQHSNLKQMSEfSVFLSLRNLIYLDISHTH 458
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdGAFKGLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNR 60
PLN03150 PLN03150
hypothetical protein; Provisional
 487-583 6.46e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.27  E-value: 6.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  487 FLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQH 566
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGG 512

                         90
                 ....*....|....*..
gi 19924149  567 FPSSLAFLNLTQNDFAC 583
Cdd:PLN03150 513 RLLHRASFNFTDNAGLC 529
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 55-187 1.82e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.70  E-value: 1.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  55 STKNLDLSFNPLRHLGSYSFFS----FPELQVLDLSRCEIQtiEDG------AYQSLSHLSTLILTGNPIQSlalgafSG 124
Cdd:COG5238 209 TVTTLWLKRNPIGDEGAEILAEalkgNKSLTTLDLSNNQIG--DEGvialaeALKNNTTVETLYLSGNQIGA------EG 280

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 125 LSSLQKLVAVETNLASL---ENfPIG------------HLKTLKELNVAHNLI--QSFK-LPEYFSNLTNLEHLDLSSNK 186
Cdd:COG5238 281 AIALAKALQGNTTLTSLdlsVN-RIGdegaialaeglqGNKTLHTLNLAYNGIgaQGAIaLAKALQENTTLHSLDLSDNQ 359


                .
gi 19924149 187 I 187
Cdd:COG5238 360 I 360
LRR_8 pfam13855
Leucine rich repeat;
520-581 3.00e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 3.00e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19924149   520 SSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPsSLAFLNLTQNDF 581
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 497-534 3.91e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 3.91e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 19924149   497 NLTFLDLSQCQLEQLSPtaFNSLSSLQVLNMSHNNFFS 534
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNKIT 37
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 468-579 6.16e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 6.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149  468 NGLSSLEVLKMAGNSFQENFLPDIFtELRNLTFLDLSQCQLE-QLSPTAFNSLSSLQVLNMSHNNFFSldTFPYKCLNSL 546
Cdd:PLN00113  66 NNSSRVVSIDLSGKNISGKISSAIF-RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTG--SIPRGSIPNL 142

                         90       100       110
                 ....*....|....*....|....*....|...
gi 19924149  547 QVLDYSLNHIMTSKKQELQHFpSSLAFLNLTQN 579
Cdd:PLN00113 143 ETLDLSNNMLSGEIPNDIGSF-SSLKVLDLGGN 174
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
409-581 8.29e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.53  E-value: 8.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 409 NGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFL 488
Cdd:COG4886   8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924149 489 -PDIFTELRNLTFLDLSQC-------QLEQLS---------PTAFNSLSSLQVLNMSHNNFFSLDTfPYKCLNSLQVLDY 551
Cdd:COG4886  88 gLTDLGDLTNLTELDLSGNeelsnltNLESLDlsgnqltdlPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDL 166

                       170       180       190
                ....*....|....*....|....*....|
gi 19924149 552 SLNHImTSKKQELQHFPsSLAFLNLTQNDF 581
Cdd:COG4886 167 SNNQL-TDLPEELGNLT-NLKELDLSNNQI 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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