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Conserved domains on  [gi|20130355|ref|NP_611912|]
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uncharacterized protein Dmel_CG3483 [Drosophila melanogaster]

Protein Classification

isocitrate/isopropylmalate dehydrogenase family protein( domain architecture ID 296)

isocitrate/isopropylmalate dehydrogenase family protein such as isocitrate dehydrogenase that in the Krebs cycle catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate and CO2, and isopropylmalate dehydrogenase that in leucine biosynthesis catalyzes the oxidation and decarboxylation of 3-isopropyl-l-malate to 4-methyl-2-oxovalerate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Iso_dh super family cl00445
Isocitrate/isopropylmalate dehydrogenase;
71-389 6.30e-103

Isocitrate/isopropylmalate dehydrogenase;


The actual alignment was detected with superfamily member TIGR00175:

Pssm-ID: 444908  Cd Length: 333  Bit Score: 307.77  E-value: 6.30e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355    71 KVTLINGEGVGRELMDAVQEVICAVKAPIEW---DVHDEFKAKDSDdvSPEVLKSLRANKVGIKGPVDSRHWQ------- 140
Cdd:TIGR00175   5 TVTLIPGDGIGPEISGSVKKIFRAANVPIEFeeiDVSPQTDGKTEI--PDEAVESIKRNKVALKGPLETPIGKgghrsln 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   141 RQIRKQFAQFAYVSLCSHIEGLDSPYGDFDVVIIRDQMEGDYSGIEHLVVPGVMQTIKVSTTAGAARIAEFVFNYAVKNK 220
Cdd:TIGR00175  83 VALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYARKNG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   221 RKRITVAHKANIMRMTDGNFLEAMRaEADKHVDDVLFEERYLDTCILKILLKPHKCDVMVSSSMYGDVLRVIAGGMMGVP 300
Cdd:TIGR00175 163 RKKVTAVHKANIMKLADGLFLNVCR-EVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVGGP 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   301 GICPGYSVSSLGTVFDcrmKACH----ALAGKDLANPTGPLLSAALMLRHVKMDKQADQVDCAIRKVYKDTDIRTPDVGG 376
Cdd:TIGR00175 242 GLVPGANIGRDYAVFE---PGVRhtgpDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGG 318

                         330
                  ....*....|...
gi 20130355   377 KAKCSEFVKAVCD 389
Cdd:TIGR00175 319 TATTSDFTEAVIK 331
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 71-389 6.30e-103

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 307.77  E-value: 6.30e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355    71 KVTLINGEGVGRELMDAVQEVICAVKAPIEW---DVHDEFKAKDSDdvSPEVLKSLRANKVGIKGPVDSRHWQ------- 140
Cdd:TIGR00175   5 TVTLIPGDGIGPEISGSVKKIFRAANVPIEFeeiDVSPQTDGKTEI--PDEAVESIKRNKVALKGPLETPIGKgghrsln 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   141 RQIRKQFAQFAYVSLCSHIEGLDSPYGDFDVVIIRDQMEGDYSGIEHLVVPGVMQTIKVSTTAGAARIAEFVFNYAVKNK 220
Cdd:TIGR00175  83 VALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYARKNG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   221 RKRITVAHKANIMRMTDGNFLEAMRaEADKHVDDVLFEERYLDTCILKILLKPHKCDVMVSSSMYGDVLRVIAGGMMGVP 300
Cdd:TIGR00175 163 RKKVTAVHKANIMKLADGLFLNVCR-EVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVGGP 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   301 GICPGYSVSSLGTVFDcrmKACH----ALAGKDLANPTGPLLSAALMLRHVKMDKQADQVDCAIRKVYKDTDIRTPDVGG 376
Cdd:TIGR00175 242 GLVPGANIGRDYAVFE---PGVRhtgpDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGG 318

                         330
                  ....*....|...
gi 20130355   377 KAKCSEFVKAVCD 389
Cdd:TIGR00175 319 TATTSDFTEAVIK 331
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 50-391 4.86e-85

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 263.28  E-value: 4.86e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   50 SKGASGKAKSAGSTDSAKKTTKVTLINGEGVGRELMDAVQEVICAVKAPIEWDVH---DEFKAKDSDDVSPEVLKSLRAN 126
Cdd:PLN00118  22 SSSSGAFSSSARAFSSSSTPITATLFPGDGIGPEIAESVKQVFTAAGVPIEWEEHyvgTTVDPRTGSFLTWESLESVRRN 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  127 KVGIKGPVDS------RHWQRQIRKQFAQFAYVSLCSHIEGLDSPYGDFDVVIIRDQMEGDYSGIEHLVVPGVMQTIKVS 200
Cdd:PLN00118 102 KVGLKGPMATpigkghRSLNLTLRKELGLYANVRPCYSLPGYKTRYDDVDLVTIRENTEGEYSGLEHQVVRGVVESLKII 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  201 TTAGAARIAEFVFNYAVKNKRKRITVAHKANIMRMTDGNFLEAMRAEADKHvDDVLFEERYLDTCILKILLKPHKCDVMV 280
Cdd:PLN00118 182 TRQASLRVAEYAFHYAKTHGRKRVSAIHKANIMKKTDGLFLKCCREVAEKY-PEIVYEEVIIDNCCMMLVKNPALFDVLV 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  281 SSSMYGDVLRVIAGGMMGVPGICPGYSVSSLGTvfdCRMKACHA----LAGKDLANPTGPLLSAALMLRHVKMDKQADQV 356
Cdd:PLN00118 261 MPNLYGDIISDLCAGLIGGLGLTPSCNIGENGL---ALAEAVHGsapdIAGKNLANPTALLLSAVMMLRHLKLNEQAEQI 337

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 20130355  357 DCAIRKVYKDTDIRTPDVGGKAKCSEFVKAVCDCL 391
Cdd:PLN00118 338 HNAILNTIAEGKYRTADLGGSSTTTDFTKAICDHL 372
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 69-391 1.79e-74

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 234.91  E-value: 1.79e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  69 TTKVTLINGEGVGRELMDAVQEVICAVKA----PIEWDVHD---EFKAKDSDDVSPEVLKSLRANKVGIKGPVDSRHWQR 141
Cdd:COG0473   1 TYKIAVLPGDGIGPEVVAAALKVLEAAAErfglDFEFEEADiggAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWDD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355 142 ---------QIRKQFAQFAYVSLCSHIEGLDSPY-----GDFDVVIIRDQMEGDYSGIEHLVVPG----VMQTIKVSTTA 203
Cdd:COG0473  81 gvrpesgllALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRVYTRK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355 204 GAARIAEFVFNYAVKNkRKRITVAHKANIMRMTDGNFLEAMRAEAdKHVDDVLFEERYLDTCILKILLKPHKCDVMVSSS 283
Cdd:COG0473 161 GIERIARYAFELARKR-RKKVTSVDKANVLKLTSGLWREVVREVA-KEYPDVELDHMYVDAAAMQLVRNPEQFDVIVTEN 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355 284 MYGDVLRVIAGGMMGVPGICPGysvSSLGT----VFDcrmkACH--A--LAGKDLANPTGPLLSAALMLRHVKMDKQADQ 355
Cdd:COG0473 239 LFGDILSDLAAGLTGSLGLAPS---ANIGDegkaLFE----PVHgsApdIAGKGIANPIATILSAAMMLRHLGEEEAADA 311

                       330       340       350
                ....*....|....*....|....*....|....*.
gi 20130355 356 VDCAIRKVYKDtDIRTPDVGGKAKCSEFVKAVCDCL 391
Cdd:COG0473 312 IEAAVEKVLAE-GVRTPDLGGKAGTSEMGDAIIAAL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
71-387 2.62e-61

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 200.98  E-value: 2.62e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355    71 KVTLINGEGVGRELMDAVQEVICAV--KAP--IEWDVHD-EFKAKDSDD--VSPEVLKSLRANKVGIKGPVDSRHWQR-- 141
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAAleKAPleFEFEERDvGGAAIDETGepLPDETLEACKKADAVLLGAVGGPKWDPag 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   142 --------QIRKQFAQFAYVSLCSHIEGLD--SPY----GDFDVVIIRDQMEGDYSGIEHLVVPG---VMQTIKVSTTAG 204
Cdd:pfam00180  81 vrpengllALRKELGLFANLRPAKVFPPLGdaSPLknevEGVDIVIVRELTGGIYFGIEKGIKGSgneVAVDTKLYSRDE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   205 AARIAEFVFNYAVKNKRKRITVAHKANIMRMTDGnFLEAMRAEADKHVDDVLFEERYLDTCILKILLKPHKCDVMVSSSM 284
Cdd:pfam00180 161 IERIARVAFELARKRGRKKVTSVDKANVLKSSDL-WRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   285 YGDVLRVIAGGMMGVPGICPGYSVSSLGT-VFDcrmkACHA----LAGKDLANPTGPLLSAALMLRH-VKMDKQADQVDC 358
Cdd:pfam00180 240 FGDILSDEASMLTGSLGLLPSASLGANGFgIFE----PVHGsapdIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEA 315

                         330       340       350
                  ....*....|....*....|....*....|..
gi 20130355   359 AIRKVYKDTdIRTPDVGGKA---KCSEFVKAV 387
Cdd:pfam00180 316 AVLKVLESG-IRTGDLAGSAtyvSTSEFGEAV 346
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 71-389 6.30e-103

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 307.77  E-value: 6.30e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355    71 KVTLINGEGVGRELMDAVQEVICAVKAPIEW---DVHDEFKAKDSDdvSPEVLKSLRANKVGIKGPVDSRHWQ------- 140
Cdd:TIGR00175   5 TVTLIPGDGIGPEISGSVKKIFRAANVPIEFeeiDVSPQTDGKTEI--PDEAVESIKRNKVALKGPLETPIGKgghrsln 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   141 RQIRKQFAQFAYVSLCSHIEGLDSPYGDFDVVIIRDQMEGDYSGIEHLVVPGVMQTIKVSTTAGAARIAEFVFNYAVKNK 220
Cdd:TIGR00175  83 VALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYARKNG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   221 RKRITVAHKANIMRMTDGNFLEAMRaEADKHVDDVLFEERYLDTCILKILLKPHKCDVMVSSSMYGDVLRVIAGGMMGVP 300
Cdd:TIGR00175 163 RKKVTAVHKANIMKLADGLFLNVCR-EVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVGGP 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   301 GICPGYSVSSLGTVFDcrmKACH----ALAGKDLANPTGPLLSAALMLRHVKMDKQADQVDCAIRKVYKDTDIRTPDVGG 376
Cdd:TIGR00175 242 GLVPGANIGRDYAVFE---PGVRhtgpDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGG 318

                         330
                  ....*....|...
gi 20130355   377 KAKCSEFVKAVCD 389
Cdd:TIGR00175 319 TATTSDFTEAVIK 331
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 50-391 4.86e-85

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 263.28  E-value: 4.86e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   50 SKGASGKAKSAGSTDSAKKTTKVTLINGEGVGRELMDAVQEVICAVKAPIEWDVH---DEFKAKDSDDVSPEVLKSLRAN 126
Cdd:PLN00118  22 SSSSGAFSSSARAFSSSSTPITATLFPGDGIGPEIAESVKQVFTAAGVPIEWEEHyvgTTVDPRTGSFLTWESLESVRRN 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  127 KVGIKGPVDS------RHWQRQIRKQFAQFAYVSLCSHIEGLDSPYGDFDVVIIRDQMEGDYSGIEHLVVPGVMQTIKVS 200
Cdd:PLN00118 102 KVGLKGPMATpigkghRSLNLTLRKELGLYANVRPCYSLPGYKTRYDDVDLVTIRENTEGEYSGLEHQVVRGVVESLKII 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  201 TTAGAARIAEFVFNYAVKNKRKRITVAHKANIMRMTDGNFLEAMRAEADKHvDDVLFEERYLDTCILKILLKPHKCDVMV 280
Cdd:PLN00118 182 TRQASLRVAEYAFHYAKTHGRKRVSAIHKANIMKKTDGLFLKCCREVAEKY-PEIVYEEVIIDNCCMMLVKNPALFDVLV 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  281 SSSMYGDVLRVIAGGMMGVPGICPGYSVSSLGTvfdCRMKACHA----LAGKDLANPTGPLLSAALMLRHVKMDKQADQV 356
Cdd:PLN00118 261 MPNLYGDIISDLCAGLIGGLGLTPSCNIGENGL---ALAEAVHGsapdIAGKNLANPTALLLSAVMMLRHLKLNEQAEQI 337

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 20130355  357 DCAIRKVYKDTDIRTPDVGGKAKCSEFVKAVCDCL 391
Cdd:PLN00118 338 HNAILNTIAEGKYRTADLGGSSTTTDFTKAICDHL 372
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 72-391 5.38e-80

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 249.78  E-value: 5.38e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   72 VTLINGEGVGRELMDAVQEVICAVKAPIEWDVHDEFKakDSDDVSPEVLKSLRANKVGIKG----PVDS--RHWQRQIRK 145
Cdd:PLN00123  33 VTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERYEVHG--DMKKVPEEVLESIRRNKVCLKGglatPVGGgvSSLNVQLRK 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  146 QFAQFAYVSLCSHIEGLDSPYGDFDVVIIRDQMEGDYSGIEHLVVPGVMQTIKVSTTAGAARIAEFVFNYAVKNKRKRIT 225
Cdd:PLN00123 111 ELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAYLNNRKKVT 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  226 VAHKANIMRMTDGNFLEAMRaEADKHVDDVLFEERYLDTCILKILLKPHKCDVMVSSSMYGDVLRVIAGGMMGVPGICPG 305
Cdd:PLN00123 191 AVHKANIMKLADGLFLESCR-EVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANTAAGIAGGTGVMPG 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  306 YSVSSLGTVFDCRMKACHA----LAGKDLANPTGPLLSAALMLRHVKMDKQADQVDCAIRKVYKDTDIRTPDVGGKAKCS 381
Cdd:PLN00123 270 GNVGADHAVFEQGASAGNVgnekLVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGKYRTKDLGGSSTTQ 349

                        330
                 ....*....|
gi 20130355  382 EFVKAVCDCL 391
Cdd:PLN00123 350 EVVDAVIANL 359
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 69-391 1.79e-74

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 234.91  E-value: 1.79e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  69 TTKVTLINGEGVGRELMDAVQEVICAVKA----PIEWDVHD---EFKAKDSDDVSPEVLKSLRANKVGIKGPVDSRHWQR 141
Cdd:COG0473   1 TYKIAVLPGDGIGPEVVAAALKVLEAAAErfglDFEFEEADiggAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWDD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355 142 ---------QIRKQFAQFAYVSLCSHIEGLDSPY-----GDFDVVIIRDQMEGDYSGIEHLVVPG----VMQTIKVSTTA 203
Cdd:COG0473  81 gvrpesgllALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRVYTRK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355 204 GAARIAEFVFNYAVKNkRKRITVAHKANIMRMTDGNFLEAMRAEAdKHVDDVLFEERYLDTCILKILLKPHKCDVMVSSS 283
Cdd:COG0473 161 GIERIARYAFELARKR-RKKVTSVDKANVLKLTSGLWREVVREVA-KEYPDVELDHMYVDAAAMQLVRNPEQFDVIVTEN 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355 284 MYGDVLRVIAGGMMGVPGICPGysvSSLGT----VFDcrmkACH--A--LAGKDLANPTGPLLSAALMLRHVKMDKQADQ 355
Cdd:COG0473 239 LFGDILSDLAAGLTGSLGLAPS---ANIGDegkaLFE----PVHgsApdIAGKGIANPIATILSAAMMLRHLGEEEAADA 311

                       330       340       350
                ....*....|....*....|....*....|....*.
gi 20130355 356 VDCAIRKVYKDtDIRTPDVGGKAKCSEFVKAVCDCL 391
Cdd:COG0473 312 IEAAVEKVLAE-GVRTPDLGGKAGTSEMGDAIIAAL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
71-387 2.62e-61

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 200.98  E-value: 2.62e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355    71 KVTLINGEGVGRELMDAVQEVICAV--KAP--IEWDVHD-EFKAKDSDD--VSPEVLKSLRANKVGIKGPVDSRHWQR-- 141
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAAleKAPleFEFEERDvGGAAIDETGepLPDETLEACKKADAVLLGAVGGPKWDPag 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   142 --------QIRKQFAQFAYVSLCSHIEGLD--SPY----GDFDVVIIRDQMEGDYSGIEHLVVPG---VMQTIKVSTTAG 204
Cdd:pfam00180  81 vrpengllALRKELGLFANLRPAKVFPPLGdaSPLknevEGVDIVIVRELTGGIYFGIEKGIKGSgneVAVDTKLYSRDE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   205 AARIAEFVFNYAVKNKRKRITVAHKANIMRMTDGnFLEAMRAEADKHVDDVLFEERYLDTCILKILLKPHKCDVMVSSSM 284
Cdd:pfam00180 161 IERIARVAFELARKRGRKKVTSVDKANVLKSSDL-WRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   285 YGDVLRVIAGGMMGVPGICPGYSVSSLGT-VFDcrmkACHA----LAGKDLANPTGPLLSAALMLRH-VKMDKQADQVDC 358
Cdd:pfam00180 240 FGDILSDEASMLTGSLGLLPSASLGANGFgIFE----PVHGsapdIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEA 315

                         330       340       350
                  ....*....|....*....|....*....|..
gi 20130355   359 AIRKVYKDTdIRTPDVGGKA---KCSEFVKAV 387
Cdd:pfam00180 316 AVLKVLESG-IRTGDLAGSAtyvSTSEFGEAV 346
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
66-387 1.46e-55

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 189.72  E-value: 1.46e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   66 AKKTTKVTLINGEGVGRELMDAVQEVICAVKAPIEWDV----HDEFKAKDSDDVSPEVLKSLRANKVGIKGPVDSRhwqr 141
Cdd:PRK09222   1 MAEKTPITVAYGDGIGPEIMEAVLKILEAAGAPLEIETieigEKVYKKGWTSGISPSAWESIRRTKVLLKAPITTP---- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  142 Q----------IRKQFAQFAYVSLC-SHIEGLDSPYGDFDVVIIRDQMEGDYSGIEHLVVPGVMQTIKVSTTAGAARIAE 210
Cdd:PRK09222  77 QgggykslnvtLRKTLGLYANVRPCvSYHPFVETKHPNLDVVIIRENEEDLYAGIEHRQTPDVYQCLKLISRPGSEKIIR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  211 FVFNYAVKNKRKRITVAHKANIMRMTDGNFLEAMRaEADKHVDDVLFEERYLDTCILKILLKPHKCDVMVSSSMYGDVLR 290
Cdd:PRK09222 157 YAFEYARANGRKKVTCLTKDNIMKLTDGLFHKVFD-EIAKEYPDIEAEHYIVDIGAARLATNPENFDVIVTPNLYGDILS 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  291 VIAGGMMGVPGICPGysvSSLGTvfDCRM-KACH----ALAGKDLANPTGPLLSAALMLRHVKMDKQADQVDCAIRKVYK 365
Cdd:PRK09222 236 DIAAEISGSVGLAGS---ANIGE--EYAMfEAVHgsapDIAGKNIANPSGLLNAAVMMLVHIGQFDIAELIENAWLKTLE 310

                        330       340
                 ....*....|....*....|....*..
gi 20130355  366 D----TDIRTPDVG-GKAKCSEFVKAV 387
Cdd:PRK09222 311 DgihtADIYNEGVSkKKVGTKEFAEAV 337
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 71-387 2.32e-51

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 174.94  E-value: 2.32e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   71 KVTLINGEGVGRELMDAVQEVICAVKAPIEW---DVHDEFKAKDSDDVSPEVLKSLRANKVGIKGPVDSRHWQR--QIRK 145
Cdd:PRK14025   3 KICVIEGDGIGKEVVPAALHVLEATGLPFEFvyaEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAGETAADVivKLRR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  146 QFAQFAYVSLCSHIEGLDSPYGDFDVVIIRDQMEGDYSGIEHLVVPGVMQTIKVSTTAGAARIAEFVFNYAVK----NKR 221
Cdd:PRK14025  83 ILDTYANVRPVKSYKGVKCLYPDIDYVIVRENTEGLYKGIEAEIADGVTVATRVITRKASERIFRFAFEMAKRrkkmGKE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  222 KRITVAHKANIMRMTDGNFLEAMRaEADKHVDDVLFEERYLDTCILKILLKPHKCDVMVSSSMYGDVLRVIAGGMMGVPG 301
Cdd:PRK14025 163 GKVTCAHKANVLKKTDGLFKKTFY-EVAKEYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFGDILSDGAAGLVGGLG 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  302 ICPGYSVSSLGTVFDCRMKACHALAGKDLANPTGPLLSAALMLRHVKMDKQADQVDCAIRKVYKDtDIRTPDVGGKAKCS 381
Cdd:PRK14025 242 LAPSANIGDKYGLFEPVHGSAPDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEEVLAL-GLTTPDLGGNLSTM 320


                 ....*.
gi 20130355  382 EFVKAV 387
Cdd:PRK14025 321 EMAEEV 326
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
42-366 3.71e-32

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 125.33  E-value: 3.71e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   42 KPPQDKQKSKGASGKAKsagstdsAKKTTKVTLINGEGVGRELMDAVQEVICAV-------KAPIEW-DVH--DEFKAKD 111
Cdd:PRK06451   3 KIPEDGEVIKFENGKWI-------VPKKPIILYVEGDGIGPEITHAAMKVINKAvekaygsDREIKWvEVLagDKAEKLT 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  112 SDDVSPEVLKSLRANKVGIKGPVDS---RHWQR---QIRKQFAQFAYVSLCSHIEGLDSPYGD---FDVVIIRDQMEGDY 182
Cdd:PRK06451  76 GNRFPKESEELIEKYRVLLKGPLETpigKGWKSinvAIRLMLDLYANIRPVKYIPGIESPLKNpekIDLIIFRENTDDLY 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  183 SGIEH-----------------LVVPGVMQT---IKVSTTAGAARIAEFVFNYAVKNKRKRITVAHKANIMRMTDGNFLE 242
Cdd:PRK06451 156 RGIEYpydseeakkirdflrkeLGVEVEDDTgigIKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFRE 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  243 -----AMRAEADKHVDD---------------VLFEERYLDTCILKILLKPHKCDVMVSSSMYGDVLRVIAGGMMGVPGI 302
Cdd:PRK06451 236 wayevALKEFRDYVVTEeevtknyngvppsgkVIINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGM 315

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  303 CPGYSVSSLGTVFDCRMKACHALAGKDLANPTGPLLSAALMLRHVKMDKQADQVDCAI------RKVYKD 366
Cdd:PRK06451 316 LGGANIGDTGGMFEAIHGTAPKYAGKNVANPTGIIKGGELMLRFMGWDKAADLIDKAImesikqKKVTQD 385
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 68-388 3.59e-30

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 118.67  E-value: 3.59e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   68 KTTKVTLINGEGVGRELMDAVQEVICAV----------KAPIEWDV-----HDEFKAKDSddvsPEVLKSLRANKVGIKG 132
Cdd:PRK08194   2 KQFKIAVIPGDGVGKEVVPAAVRVLKAVaevhgglkfeFTEFPWSCeyyleHGEMMPEDG----LEQLKQFDAIFLGAVG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  133 -----PVDSRHWQR--QIRKQFAQFAYVSLCSHIEGLDSPY---GDFDVVIIRDQMEGDYSGI-------EHLVVpgvMQ 195
Cdd:PRK08194  78 npklvPDHISLWGLliKIRREFEQVINIRPAKQLRGIKSPLanpKDFDLLVVRENSEGEYSEVggrihrgEDEIA---IQ 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  196 TiKVSTTAGAARIAEFVFNYAvKNKRKRITVAHKAN--IMRMTdgnFLEAMRAEADKHVDDVLFEERYLDTCILKILLKP 273
Cdd:PRK08194 155 N-AVFTRKGTERAMRYAFELA-AKRRKHVTSATKSNgiVHSMP---FWDEVFQEVGKDYPEIETDSQHIDALAAFFVTRP 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  274 HKCDVMVSSSMYGDVLRVIAGGMMGVPGICPGYSVSSLGT---VFDCRMKACHALAGKDLANPTGPLLSAALMLRHVKMD 350
Cdd:PRK08194 230 EEFDVIVASNLFGDILTDIGAAIMGSIGIAPAANINVNGKypsMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLDHFGEE 309

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 20130355  351 KQADQVDCAIRKVYKDtDIRTPDVGGKAKCSEFVKAVC 388
Cdd:PRK08194 310 ELGSHLLDVIEDVTED-GIKTPDIGGRATTDEVTDEII 346
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 68-387 8.39e-23

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 98.25  E-value: 8.39e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   68 KTTKVTLINGEGVGRELMDAVQEVICAVKA----PIEWDVH-------DEF----------KAKDSD------------- 113
Cdd:PRK00772   1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEkfgfDFEFEEAlvggaaiDAHgvplpeetleACRAADavllgavggpkwd 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  114 ----DVSPEvlKSLRAnkvgikgpvdsrhwqrqIRKQFAQFA-------YVSL---CS----HIEGldspygdFDVVIIR 175
Cdd:PRK00772  81 nlppDVRPE--RGLLA-----------------LRKELGLFAnlrpaklYPGLadaSPlkpeIVAG-------LDILIVR 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  176 DQMEGDYSG----IEHLVVPGVMQTIKVSTTAGAARIAEFVFNYAvKNKRKRITVAHKANIMRmTDGNFLEAMRAEADKH 251
Cdd:PRK00772 135 ELTGGIYFGeprgREGLGGEERAFDTMVYTREEIERIARVAFELA-RKRRKKVTSVDKANVLE-SSRLWREVVTEVAKEY 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  252 vDDVLFEERYLDTCILKILLKPHKCDVMVSSSMYGDVLR----VIAGGMmgvpGICPgySvSSLGTvfdcrmkACHAL-- 325
Cdd:PRK00772 213 -PDVELSHMYVDNAAMQLVRNPKQFDVIVTENLFGDILSdeaaMLTGSL----GMLP--S-ASLGE-------SGPGLye 277

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20130355  326 ---------AGKDLANPTGPLLSAALMLRH-VKMDKQADQVDCAIRKVYKDtDIRTPDV---GGKAKCSEFVKAV 387
Cdd:PRK00772 278 pihgsapdiAGKGIANPIATILSAAMMLRYsLGLEEAADAIEAAVEKVLAQ-GYRTADIaegGGKVSTSEMGDAI 351
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 75-383 2.32e-22

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 97.82  E-value: 2.32e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   75 INGEGVGRELMDAVQEVICAV-------KAPIEW-DVHDEFKAKD--SDDV--SPEVLKSLRANKVGIKGPVDS------ 136
Cdd:PRK07006  25 IEGDGIGPDITPAMLKVVDAAvekaykgERKISWmEIYAGEKATKvyGEDVwlPEETLDLIREYRVAIKGPLTTpvgggi 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  137 RHWQRQIRKQFAQFAYVSLCSHIEGLDSPYG---DFDVVIIRDQMEGDYSGIEHLV-------VPGVMQT---------- 196
Cdd:PRK07006 105 RSLNVALRQELDLYVCLRPVRYFKGVPSPVKrpeDTDMVIFRENSEDIYAGIEWKAgsaeakkVIKFLQEemgvkkirfp 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  197 ------IKVSTTAGAARIAEFVFNYAVKNKRKRITVAHKANIMRMTDGNFLE-----AMRAEADKHVD------------ 253
Cdd:PRK07006 185 etsgigIKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDwgyqlAEEEFGDELIDggpwdkiknpet 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  254 --DVLFEERYLDTCILKILLKPHKCDVMVSSSMYGDVLRVIAGGMMGVPGICPGYSVSSLGTVFDcrmkACHA----LAG 327
Cdd:PRK07006 265 gkEIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANINDGHAIFE----ATHGtapkYAG 340

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20130355  328 KDLANPTGPLLSAALMLRHVKMDKQADQVDCAIRKVYKDTDI-----RTPDVGGKAKCSEF 383
Cdd:PRK07006 341 LDKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTIASKTVtydfaRLMEGATEVKCSEF 401
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 75-389 2.09e-19

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 89.01  E-value: 2.09e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  75 INGEGVGRELMDAVQEVI-CAVKAP------IEW---DVHDEFKAKDSDDVSPEVLKSLRANKVGIKGPV---DSRHWqR 141
Cdd:COG0538  24 IEGDGIGPEITRAIWKVIdAAVEKAyggkrdIEWkevDAGEKARDETGDWLPDETAEAIKEYGVGIKGPLttpVGGGW-R 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355 142 Q----IRKQFAQFAYVSLCSHIEGLDSP---YGDFDVVIIRDQMEGDYSGIEHLV-VPGVMQ------------------ 195
Cdd:COG0538 103 SlnvtIRQILDLYVCRRPVRYFKGVPSPvkhPEKVDIVIFRENTEDIYAGIEWKAgSPEALKliffledemgvtvirfpe 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355 196 ----TIKVSTTAGAARIAEFVFNYAVKNKRKRITVAHKANIMRMTDGNFLEAMRAEADKHVDDVLFEERYLDTCILK--- 268
Cdd:COG0538 183 dsgiGIKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAFKDWGYEVAEEEFGDKFITEGPWEKYKGPkpa 262

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355 269 ----------------ILLKPHKCDVMVSSSMYGDVLRVIAGGMMGVPGICPGYSVSSLGT-VFDcrmkACHA----LAG 327
Cdd:COG0538 263 gkivykdriaddmlqqILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGDDGGaEFE----ATHGtapkYAG 338

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20130355 328 KDLANPTGPLLSAALMLRHVKMDKQADQVDCAI------RKVYKDTDIRTPDVgGKAKCSEFVKAVCD 389
Cdd:COG0538 339 KDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVektiesGKVTYDLARLMEGA-TELSTSEFGDAIIE 405
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 68-375 1.87e-17

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 82.67  E-value: 1.87e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   68 KTTKVTLINGEGVGRELMDAVQEVICAVKAP------IEWDVHDEFKAKDSDDVSPEVLKSLRANKV----GIKGP-VDS 136
Cdd:PRK03437   3 KTMKLAVIPGDGIGPEVVAEALKVLDAVAAGgpgvetTEYDLGARRYLRTGETLPDSVLAELRQHDAillgAIGDPsVPS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  137 RHWQRQI--RKQFAQFAYVSL--CSHIEGLDSPY---GDFDVVIIRDQMEGDYSGIEHLVVPG----VMQTIKVSTTAGA 205
Cdd:PRK03437  83 GVLERGLllKLRFALDHYVNLrpSKLYPGVTSPLagpGDIDFVVVREGTEGPYTGNGGALRVGtpheVATEVSVNTAFGV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  206 ARIAEFVFNYAVKNKRKRITVAHKANIMRMTdGNFLEAMRAEADKHVDDVLFEERYLDTCILKILLKPHKCDVMVSSSMY 285
Cdd:PRK03437 163 ERVVRDAFERAQKRPRKHLTLVHKTNVLTFA-GDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTDPSRFDVIVTDNLF 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  286 GDVLRVIAGGMMGVPGICPGYSVSSLGTvFDCRMKACHA----LAGKDLANPTGPLLSAALMLRHVKMDKQADQVDCAIR 361
Cdd:PRK03437 242 GDIITDLAAAVTGGIGLAASGNINPTGT-NPSMFEPVHGsapdIAGQGIADPTAAILSVALLLDHLGEEDAAARIEAAVE 320

                        330
                 ....*....|....*..
gi 20130355  362 KVYKDTD---IRTPDVG 375
Cdd:PRK03437 321 ADLAERGkmgRSTAEVG 337
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 170-387 3.25e-12

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 67.41  E-value: 3.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  170 DVVIIRDQMEGDYSGIEH-LVVPGVMQTIKVSTTAGAA----RIAEFVFNYAVKnKRKRITVAHKANIMrmtDGNFLEAM 244
Cdd:PLN02329 173 DMMIVRELTGGIYFGEPRgITINENGEEVGVSTEIYAAheidRIARVAFETARK-RRGKLCSVDKANVL---DASILWRK 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  245 RAEA-DKHVDDVLFEERYLDTCILKILLKPHKCDVMVSSSMYGDVLRVIAGGMMGVPGICPGYSVSSLGT-VFDCRMKAC 322
Cdd:PLN02329 249 RVTAlASEYPDVELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPgLFEPIHGSA 328

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20130355  323 HALAGKDLANPTGPLLSAALMLRHVKMDKQA-----DQVDCAIRKVYKDTDIRTPD---VGGKAKCSEFVKAV 387
Cdd:PLN02329 329 PDIAGQDKANPLATILSAAMLLKYGLGEEKAakrieDAVVDALNKGFRTGDIYSPGnklVGCKEMGEEVLKSV 401
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
72-387 3.84e-10

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 61.27  E-value: 3.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355   72 VTLINGEGVGRELMDAVQEVICAVKAP-------IEWdvhdeFKAKDSDDVS---------PE-VLKSLRANKVGIKGPV 134
Cdd:PRK07362  31 IPFIRGDGTGVDIWPATQKVLDAAVAKayggerkINW-----FKVYAGDEACdlygtyqylPEdTLEAIREYGVAIKGPL 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  135 DS------RHWQRQIRKQFAQFAYVSLCSHIEGLDSPYG---DFDVVIIRDQMEGDYSGIE-------------HL---V 189
Cdd:PRK07362 106 TTpigggiRSLNVALRQIFDLYSCVRPCRYYAGTPSPHKnpeKLDVIVYRENTEDIYMGIEweagdeigdklikHLneeV 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  190 VP-----GVMQT-------IKVSTTAGAARIAEFVFNYAVK-NKRKR-ITVAHKANIMRMTDGNF--------------- 240
Cdd:PRK07362 186 IPaspelGKRQIplgsgigIKPVSKTGSQRHIRRAIEHALRlPGDKRhVTLVHKGNIMKYTEGAFrdwgyelattefrde 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  241 --------------------LEA---------------MRAEADKHVDDVL-----------------FEERYLDTCILK 268
Cdd:PRK07362 266 cvtereswilsnkeknpnisIEDnarmiepgydsltpeKKAAICAEVKEVLdsiwsshgngkwkekvlVDDRIADSIFQQ 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130355  269 ILLKPHKCDVMVSSSMYGDVLRVIAGGMMGVPGICPGYSVSSLGTVFDCRMKACHALAGKDLANPTGPLLSAALMLRHVK 348
Cdd:PRK07362 346 IQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAAIFEATHGTAPKHAGLDRINPGSVILSGVMMLEYLG 425

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 20130355  349 MDKQADQVDCAI------RKV-YKDTDIRTPDVgGKAKCSEFVKAV 387
Cdd:PRK07362 426 WQEAADLITKGLsaaianKQVtYDLARLMEPPV-DPLSCSEFAEAI 470
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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