|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
391-653 |
1.27e-153 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 467.76 E-value: 1.27e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 391 IKPHQIGGVRFLYDNIIESTRRYNKSSGFGCILAHSMGLGKTLQVVSFCDIFLRHTSAKTVLCVMPINTLQNWLSEFNMW 470
Cdd:cd18069 1 LKPHQIGGIRFLYDNIIESLERYKGSSGFGCILAHSMGLGKTLQVISFLDVLLRHTGAKTVLAIVPVNTLQNWLSEFNKW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 471 IPRYSTDSNVRPRNFDIFVLNDQQKTLTARAKVILNWVHDGGVLLIGYELFRLlalklvktrkrkgsvirpdgmdsssdl 550
Cdd:cd18069 81 LPPPEALPNVRPRPFKVFILNDEHKTTAARAKVIEDWVKDGGVLLMGYEMFRL--------------------------- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 551 mnlvyealvKPGPDLVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTEFCNMF 630
Cdd:cd18069 134 ---------RPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMF 204
|
250 260
....*....|....*....|...
gi 62484263 631 ERPIQNGQCVDSTPDDIKLMRYR 653
Cdd:cd18069 205 ERPILNGQCVDSTPQDVKLMRYR 227
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
391-653 |
1.24e-101 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 325.40 E-value: 1.24e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 391 IKPHQIGGVRFLYDNIIESTRryNKSSGFGCILAHSMGLGKTLQVVSFCDIFLRHTS-AKTVLCVMPINTLQNWLSEFNM 469
Cdd:cd18007 1 LKPHQVEGVRFLWSNLVGTDV--GSDEGGGCILAHTMGLGKTLQVITFLHTYLAAAPrRSRPLVLCPASTLYNWEDEFKK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 470 WIPRYstdsnvrPRNFDIFVLNDQQKTLTARAKVILNWVHDGGVLLIGYELFRLLALKLVKTRKRKGSVIRpdgmdsssd 549
Cdd:cd18007 79 WLPPD-------LRPLLVLVSLSASKRADARLRKINKWHKEGGVLLIGYELFRNLASNATTDPRLKQEFIA--------- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 550 lmnlvyeALVKPGPDLVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTEFCNM 629
Cdd:cd18007 143 -------ALLDPGPDLLVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKK 215
|
250 260
....*....|....*....|....
gi 62484263 630 FERPIQNGQCVDSTPDDIKLMRYR 653
Cdd:cd18007 216 FVKPIEAGQCVDSTEEDVRLMLKR 239
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
391-653 |
3.71e-82 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 270.22 E-value: 3.71e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 391 IKPHQIGGVRFLYDNIIESTRRYNKSSGFGCILAHSMGLGKTLQVVSFCDIFLRH---TSAKTVLCVMPINTLQNWLSEF 467
Cdd:cd18068 1 LKPHQVDGVQFMWDCCCESLKKTKKSPGSGCILAHCMGLGKTLQVVTFLHTVLLCeklENFSRVLVVCPLNTVLNWLNEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 468 NMWIprystDSNVRPRNFDIFVLnDQQKTLTARAKVILNWVHDGGVLLIGYELFRLLAL-KLVKTRKRKGSVIRpdgmds 546
Cdd:cd18068 81 EKWQ-----EGLKDEEKIEVNEL-ATYKRPQERSYKLQRWQEEGGVMIIGYDMYRILAQeRNVKSREKLKEIFN------ 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 547 ssdlmnlvyEALVKPGPDLVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTEF 626
Cdd:cd18068 149 ---------KALVDPGPDFVVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEF 219
|
250 260
....*....|....*....|....*..
gi 62484263 627 CNMFERPIQNGQCVDSTPDDIKLMRYR 653
Cdd:cd18068 220 RNRFVNPIQNGQCADSTLVDVRVMKKR 246
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
392-1121 |
6.20e-64 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 232.04 E-value: 6.20e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 392 KPHQIGGVRFLydniiestrRYNKSSGFGCILAHSMGLGKTLQVVSFCDIFLRHTSAKTVLCVMPINTLQNWLSEFNMWI 471
Cdd:COG0553 243 RPYQLEGAAWL---------LFLRRLGLGGLLADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKFA 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 472 PrystdsnvrprNFDIFVLNDQQKtltaRAKvILNWVHDGGVLLIGYELFRllalklvktrkrkgsvirpdgmdssSDLm 551
Cdd:COG0553 314 P-----------GLRVLVLDGTRE----RAK-GANPFEDADLVITSYGLLR-------------------------RDI- 351
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 552 nlvyEALVKPGPDLVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTEFCNMFE 631
Cdd:COG0553 352 ----ELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFA 427
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 632 RPIQNGQcvdstpddiklmRYRAHVLHSLLLGFVQRRshtvlqltlpqkyeyvilvkmtafqrklydtfmtdvvrTKAfp 711
Cdd:COG0553 428 RPIEKGD------------EEALERLRRLLRPFLLRR--------------------------------------TKE-- 455
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 712 nplkafavcckiwnhpDVLYNFLKKCETDLDLEIDEEvtkgaatpivepsadsslslasplEKKIngsgdpinsietfsk 791
Cdd:COG0553 456 ----------------DVLKDLPEKTEETLYVELTPE------------------------QRAL--------------- 480
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 792 aenqtlfnipassdlnakylnkspsfYDEkpeplnygsfgsegknnywmdssilpkpgcveVIKQTDTNMSSnfesitgs 871
Cdd:COG0553 481 --------------------------YEA--------------------------------VLEYLRRELEG-------- 494
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 872 seivdldtneiktvettiqapcsnnqldngcnagkpsewnAAGSKNSSGVaaaepFKKLLKSKQrneeFSCSWAvdLMKN 951
Cdd:COG0553 495 ----------------------------------------AEGIRRRGLI-----LAALTRLRQ----ICSHPA--LLLE 523
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 952 YVSGLISNSPKMEIFFCILKESLNLGDRILLFSQSLLTLNLLEVYLKSSYVPgsnqlwtknssYFRLDGSTSSQERERLV 1031
Cdd:COG0553 524 EGAELSGRSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIE-----------YAYLHGGTSAEERDELV 592
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 1032 NEFNANSNVKLFLISTRAGSLGINLTGANRVIIFDASWNPCHDTQAVYRIYRYGQTKPCFVYRIVMDRCLEKKIYDRQIK 1111
Cdd:COG0553 593 DRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEE 672
|
730
....*....|
gi 62484263 1112 KQGMSDRIVD 1121
Cdd:COG0553 673 KRALAESVLG 682
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
394-730 |
1.20e-62 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 216.01 E-value: 1.20e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 394 HQIGGVRFLYDniiestrRYNKSsGFGCILAHSMGLGKTLQVVSFCdIFLRHTSAKT---VLCVMPINTLQNWLSEFNMW 470
Cdd:pfam00176 1 YQIEGVNWMLS-------LENNL-GRGGILADEMGLGKTLQTISLL-LYLKHVDKNWggpTLIVVPLSLLHNWMNEFERW 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 471 -----IPRYSTDSNVRPRNfdifvlndqqktltaRAKVILNWVHDGGVLLIGYElfrllalklvktRKRKgsvirpdgmd 545
Cdd:pfam00176 72 vsppaLRVVVLHGNKRPQE---------------RWKNDPNFLADFDVVITTYE------------TLRK---------- 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 546 sssdlmnlVYEALVKPGPDLVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTE 625
Cdd:pfam00176 115 --------HKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGTPLQNNLEELWALLNFLRPGPFGSLST 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 626 FCNMFERPIQNGQcvdstpddiklMRYRAHVLHSLLLGFVQRRSHTVLQLTLPQKYEYVILVKMTAFQRKLYDTFMTDvV 705
Cdd:pfam00176 187 FRNWFDRPIERGG-----------GKKGVSRLHKLLKPFLLRRTKKDVEKSLPPKVEYILFCRLSKLQRKLYQTFLLK-K 254
|
330 340 350
....*....|....*....|....*....|....*
gi 62484263 706 RTKAFPNPLKAFAVCC----------KIWNHPDVL 730
Cdd:pfam00176 255 DLNAIKTGEGGREIKAsllnilmrlrKICNHPGLI 289
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
393-668 |
1.92e-60 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 207.52 E-value: 1.92e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 393 PHQIGGVRFLYDNIiestRRYNKSSGFGCILAHSMGLGKTLQVVSFCDIFLRHTS-----AKTVLCVMPINTLQNWLSEF 467
Cdd:cd18004 3 PHQREGVQFLYDCL----TGRRGYGGGGAILADEMGLGKTLQAIALVWTLLKQGPygkptAKKALIVCPSSLVGNWKAEF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 468 NMWIPR-----YSTDSNVRPRNFDIfvlndQQKTLTARAKvilnwvhdggVLLIGYELFRLLALKLVKTRKrkgsvirpd 542
Cdd:cd18004 79 DKWLGLrrikvVTADGNAKDVKASL-----DFFSSASTYP----------VLIISYETLRRHAEKLSKKIS--------- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 543 gmdsssdlmnlvyealvkpgPDLVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGT 622
Cdd:cd18004 135 --------------------IDLLICDEGHRLKNSESKTTKALNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGS 194
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 62484263 623 RTEFCNMFERPIQNGQCVDSTPDDIKLMRYRAHVLHSLLLGFVQRR 668
Cdd:cd18004 195 LASFRKVFEEPILRSRDPDASEEDKELGAERSQELSELTSRFILRR 240
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
960-1096 |
1.44e-51 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 178.05 E-value: 1.44e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 960 SPKMEIFFCILKESLNLGDRILLFSQSLLTLNLLEVYLKSSYVpgsnqlwtknsSYFRLDGSTSSQERERLVNEFNANSN 1039
Cdd:cd18793 10 SGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGI-----------KYLRLDGSTSSKERQKLVDRFNEDPD 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 62484263 1040 VKLFLISTRAGSLGINLTGANRVIIFDASWNPCHDTQAVYRIYRYGQTKPCFVYRIV 1096
Cdd:cd18793 79 IRVFLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
392-620 |
9.57e-47 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 166.20 E-value: 9.57e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 392 KPHQIGGVRFLYDniiestrRYNKssGFGCILAHSMGLGKTLQVVSFCDIFLRH-TSAKTVLCVMPINTLQNWLSEFNMW 470
Cdd:cd17919 2 RPYQLEGLNFLLE-------LYEN--GPGGILADEMGLGKTLQAIAFLAYLLKEgKERGPVLVVCPLSVLENWEREFEKW 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 471 IPrystdsnvrprNFDIFVLNDQQKTltARAKVILNWVHDGGVLLIGYELFRLLAlklvktrkrkgsvirpdgmdsssdl 550
Cdd:cd17919 73 TP-----------DLRVVVYHGSQRE--RAQIRAKEKLDKFDVVLTTYETLRRDK------------------------- 114
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 551 mnlvyEALVKPGPDLVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYL 620
Cdd:cd17919 115 -----ASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTPLQNNLEELWALLDFLDPPFL 179
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
391-668 |
2.20e-42 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 155.71 E-value: 2.20e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 391 IKPHQIGGVRFLYDNIiesTRRYNKSSgFGCILAHSMGLGKTLQVVSFCDIFLRHT-----SAKTVLCVMPINTLQNWLS 465
Cdd:cd18067 1 LRPHQREGVKFLYRCV---TGRRIRGS-HGCIMADEMGLGKTLQCITLMWTLLRQSpqckpEIDKAIVVSPSSLVKNWAN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 466 EFNMWIprystDSNVRPrnfdiFVLNDQQKTLTARAKVilNWVHDGG------VLLIGYELFRLLALKLvktrkRKGSVi 539
Cdd:cd18067 77 ELGKWL-----GGRLQP-----LAIDGGSKKEIDRKLV--QWASQQGrrvstpVLIISYETFRLHVEVL-----QKGEV- 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 540 rpdgmdsssdlmnlvyealvkpgpDLVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNY 619
Cdd:cd18067 139 ------------------------GLVICDEGHRLKNSDNQTYQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGI 194
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 62484263 620 LGTRTEFCNMFERPIQNGQCVDSTPDDIKLMRYRAHVLHSLLLGFVQRR 668
Cdd:cd18067 195 LGTAAEFKKNFELPILKGRDADASEKERQLGEEKLQELISIVNRCIIRR 243
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
391-668 |
7.41e-41 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 151.38 E-value: 7.41e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 391 IKPHQIGGVRFLYDNIIEstrrynkssGFGCILAHSMGLGKTLQVVSFCDIFLRHT---------------------SAK 449
Cdd:cd18005 1 LRDYQREGVEFMYDLYKN---------GRGGILGDDMGLGKTVQVIAFLAAVLGKTgtrrdrennrprfkkkppassAKK 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 450 TVLCVMPINTLQNWLSEFNMWiprystdsnvrpRNFDIFVLNDQQKT--LTARAKVilnwvhdGG--VLLIGYELFRLLA 525
Cdd:cd18005 72 PVLIVAPLSVLYNWKDELDTW------------GHFEVGVYHGSRKDdeLEGRLKA-------GRleVVVTTYDTLRRCI 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 526 lklvktrkrkgsvirpdgmDSSSDLmnlvyealvkpGPDLVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNL 605
Cdd:cd18005 133 -------------------DSLNSI-----------NWSAVIADEAHRIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNM 182
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62484263 606 LEYWCMVDFVRPNYLGTRTEFCNMFERPIQNGQCVDSTPDDIKLMRYRAHVLHSLLLGFVQRR 668
Cdd:cd18005 183 KELWCLLDWAVPGALGSRSQFKKHFSEPIKRGQRHTATARELRLGRKRKQELAVKLSKFFLRR 245
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
391-668 |
5.06e-39 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 145.76 E-value: 5.06e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 391 IKPHQIGGVRFLYDNIIesTRRYNKssGFGCILAHSMGLGKTLQVVSFCDIFLRHTS------AKTVLCVMPINTLQNWL 464
Cdd:cd18066 1 LRPHQREGIEFLYECVM--GMRVNE--RFGAILADEMGLGKTLQCISLIWTLLRQGPyggkpvIKRALIVTPGSLVKNWK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 465 SEFNMWIPRystdsnvrpRNFDIFVLnDQQKTLTARAKVILNwvhdgGVLLIGYE-LFRLLAlklvktrkrkgsvirpdg 543
Cdd:cd18066 77 KEFQKWLGS---------ERIKVFTV-DQDHKVEEFIASPLY-----SVLIISYEmLLRSLD------------------ 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 544 mdsssDLMNLVYealvkpgpDLVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTR 623
Cdd:cd18066 124 -----QISKLNF--------DLVICDEGHRLKNTSIKTTTALTSLSCERRIILTGTPIQNDLQEFFALIDFVNPGILGSL 190
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 62484263 624 TEFCNMFERPIQNGQCVDSTPDDIKLMRYRAHVLHSLLLGFVQRR 668
Cdd:cd18066 191 STYRKVYEEPIVRSREPTATPEEKKLGEARAAELTRLTGLFILRR 235
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
393-668 |
6.50e-39 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 145.59 E-value: 6.50e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 393 PHQIGGVRFLYdniiestRRYnkSSGFGCILAHSMGLGKTLQVVSFCDIFLRHTSAKTVLCVMPINTLQNWLSEFNMWIP 472
Cdd:cd18001 3 PHQREGVAWLW-------SLH--DGGKGGILADDMGLGKTVQICAFLSGMFDSGLIKSVLVVMPTSLIPHWVKEFAKWTP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 473 RystdsnVRPRNFdifvlndqQKTLTARAKVILNWVH-DGGVLLIGYelfrllalklvktrkrkGSVIRPDGMDSSSDLM 551
Cdd:cd18001 74 G------LRVKVF--------HGTSKKERERNLERIQrGGGVLLTTY-----------------GMVLSNTEQLSADDHD 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 552 NLVYealvkpgpDLVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRP-NYLGTRTEFCNMF 630
Cdd:cd18001 123 EFKW--------DYVILDEGHKIKNSKTKSAKSLREIPAKNRIILTGTPIQNNLKELWALFDFACNgSLLGTRKTFKMEF 194
|
250 260 270
....*....|....*....|....*....|....*...
gi 62484263 631 ERPIQNGQCVDSTPDDIKLMRYRAHVLHSLLLGFVQRR 668
Cdd:cd18001 195 ENPITRGRDKDATQGEKALGSEVAENLRQIIKPYFLRR 232
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
393-620 |
1.22e-36 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 137.46 E-value: 1.22e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 393 PHQIGGVRFLYdniiESTRRynkssGFGCILAHSMGLGKTLQVVSFCdIFLRHTSA--KTVLCVMPINTLQNWLSEFNMW 470
Cdd:cd18000 3 KYQQTGVQWLW----ELHCQ-----RVGGILGDEMGLGKTIQIIAFL-AALHHSKLglGPSLIVCPATVLKQWVKEFHRW 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 471 IPR------YSTDSNVRPRnfdifvlnDQQKTLTARAKVILNWVHDGGVLLIGYELFRLLALKLVKTrkrkgsvirpdgm 544
Cdd:cd18000 73 WPPfrvvvlHSSGSGTGSE--------EKLGSIERKSQLIRKVVGDGGILITTYEGFRKHKDLLLNH------------- 131
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62484263 545 dsssdlmNLVYealvkpgpdlVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYL 620
Cdd:cd18000 132 -------NWQY----------VILDEGHKIRNPDAEITLACKQLRTPHRLILSGTPIQNNLKELWSLFDFVFPPYL 190
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
393-638 |
4.48e-32 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 125.37 E-value: 4.48e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 393 PHQIGGVRFLydniiestrRYNKSSGFGCILAHSMGLGKTLQVVSFCDIFLRHTSAKTVLCVMPINTLQNWLSEFNMWIP 472
Cdd:cd18012 7 PYQKEGFNWL---------SFLRHYGLGGILADDMGLGKTLQTLALLLSRKEEGRKGPSLVVAPTSLIYNWEEEAAKFAP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 473 rystdsnvrprNFDIFVLNDqqktlTARAKVILNWVHDGGVLLIGYELFRllalklvktrkrkgsvirpdgmdssSDLmn 552
Cdd:cd18012 78 -----------ELKVLVIHG-----TKRKREKLRALEDYDLVITSYGLLR-------------------------RDI-- 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 553 lvyEALVKPGPDLVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTEFCNMFER 632
Cdd:cd18012 115 ---ELLKEVKFHYLVLDEAQNIKNPQTKTAKAVKALKADHRLALTGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRFAK 191
|
....*.
gi 62484263 633 PIQNGQ 638
Cdd:cd18012 192 PIEKDG 197
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
387-1112 |
2.53e-31 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 134.16 E-value: 2.53e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 387 IAKVIKPHQIGGVRF---LYDNiiestrrynkssGFGCILAHSMGLGKTLQVVS-------FCDIFLRHtsaktvLCVMP 456
Cdd:PLN03142 166 IKGKMRDYQLAGLNWlirLYEN------------GINGILADEMGLGKTLQTISllgylheYRGITGPH------MVVAP 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 457 INTLQNWLSEFNMWIPRystdsnVRPRNFdifvLNDQQktltARAKVILNWVHDGG--VLLIGYELfrllALKLVKTRKR 534
Cdd:PLN03142 228 KSTLGNWMNEIRRFCPV------LRAVKF----HGNPE----ERAHQREELLVAGKfdVCVTSFEM----AIKEKTALKR 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 535 kgsvirpdgmdsssdlMNLVYealvkpgpdlVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDF 614
Cdd:PLN03142 290 ----------------FSWRY----------IIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNF 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 615 VRPNYLGTRTEFCNMFERPIQNGQcvdstpddiklmryrAHV---LHSLLLGFVQRRSHTVLQLTLPQKYEYVILVKMTA 691
Cdd:PLN03142 344 LLPEIFSSAETFDEWFQISGENDQ---------------QEVvqqLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQ 408
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 692 FQRKLYdtfmtdvvrtkafpnplKAFavcckiwnhpdvlynfLKKcetdlDLEIdeevtkgaatpivepsadsslslasp 771
Cdd:PLN03142 409 MQKQYY-----------------KAL----------------LQK-----DLDV-------------------------- 424
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 772 lekkINGSGdpinsietfskaENQTLFNIpassdlnAKYLNKspsfydekpeplnygsfgsegknnywmdssilpkpgCv 851
Cdd:PLN03142 425 ----VNAGG------------ERKRLLNI-------AMQLRK------------------------------------C- 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 852 evikqtdtnmssnfesitgsseivdldtneiktvettiqapCSNNQLDNGCNAGKPsewnaagsknssgvaaaepfkkll 931
Cdd:PLN03142 445 -----------------------------------------CNHPYLFQGAEPGPP------------------------ 459
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 932 kskqrneefscswavdlmknYVSG--LISNSPKMEIFFCILKESLNLGDRILLFSQSLLTLNLLEVYLKssyvpgsnqlw 1009
Cdd:PLN03142 460 --------------------YTTGehLVENSGKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLM----------- 508
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 1010 TKNSSYFRLDGSTSSQERERLVNEFNA-NSNVKLFLISTRAGSLGINLTGANRVIIFDASWNPCHDTQAVYRIYRYGQTK 1088
Cdd:PLN03142 509 YRGYQYCRIDGNTGGEDRDASIDAFNKpGSEKFVFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKK 588
|
730 740
....*....|....*....|....
gi 62484263 1089 PCFVYRIVMDRCLEKKIYDRQIKK 1112
Cdd:PLN03142 589 EVQVFRFCTEYTIEEKVIERAYKK 612
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
391-668 |
4.94e-25 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 105.51 E-value: 4.94e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 391 IKPHQIGGVR---FLydniiestRRYNKSSgfgcILAHSMGLGKTLQvvSFC----DIFLRHTSAKT----VLCVMPINT 459
Cdd:cd17999 1 LRPYQQEGINwlaFL--------NKYNLHG----ILCDDMGLGKTLQ--TLCilasDHHKRANSFNSenlpSLVVCPPTL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 460 LQNWLSEFNmwipRYSTDSNVRPRNFDifvlNDQQKTLTARAKVilnwvHDGGVLLIGYElfrllalklvktrkrkgsVI 539
Cdd:cd17999 67 VGHWVAEIK----KYFPNAFLKPLAYV----GPPQERRRLREQG-----EKHNVIVASYD------------------VL 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 540 RPDgmdsssdlmnlvYEALVKPGPDLVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNY 619
Cdd:cd17999 116 RND------------IEVLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLKANHRLILSGTPIQNNVLELWSLFDFLMPGY 183
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 62484263 620 LGTRTEFCNMFERPIQNGQCVDSTPDDIKLMRYRAHVLHSLLLGFVQRR 668
Cdd:cd17999 184 LGTEKQFQRRFLKPILASRDSKASAKEQEAGALALEALHKQVLPFLLRR 232
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
391-668 |
6.53e-25 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 105.14 E-value: 6.53e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 391 IKPHQIGGVRF---LYDNiiestrrynKSSGfgcILAHSMGLGKTLQVVSF-CDIFLRHTSAKTVLCVMPINTLQNWLSE 466
Cdd:cd17996 4 LKEYQLKGLQWmvsLYNN---------NLNG---ILADEMGLGKTIQTISLiTYLMEKKKNNGPYLVIVPLSTLSNWVSE 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 467 FNMWIPRYSTDSNVRPRNfdifvlndqqktltarakvilnwvhdggvlligyelfrllalklvkTRKRKGSVIRPdgmdS 546
Cdd:cd17996 72 FEKWAPSVSKIVYKGTPD----------------------------------------------VRKKLQSQIRA----G 101
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 547 SSDLMNLVYEALVKPGPDL-------VICDEGHRIKNSHAGISLALKE-IRTRRRIVLTGYPLQNNLLEYWCMVDFVRPN 618
Cdd:cd17996 102 KFNVLLTTYEYIIKDKPLLskikwkyMIIDEGHRMKNAQSKLTQTLNTyYHARYRLLLTGTPLQNNLPELWALLNFLLPK 181
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 62484263 619 YLGTRTEFCNMFERPIQN--GQCVDSTPDDIKLMRYRAhvLHSLLLGFVQRR 668
Cdd:cd17996 182 IFKSCKTFEQWFNTPFANtgEQVKIELNEEETLLIIRR--LHKVLRPFLLRR 231
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
392-630 |
7.38e-25 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 104.64 E-value: 7.38e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 392 KPHQIGGVRFLYDNIiestrrYNKSsgfGCILAHSMGLGKTLQVVSFCD-IFLRHTSAKTVLCVMPINTLQNWLSEFNMW 470
Cdd:cd17995 2 RDYQLEGVNWLLFNW------YNRR---NCILADEMGLGKTIQSIAFLEhLYQVEGIRGPFLVIAPLSTIPNWQREFETW 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 471 iprysTDSNVrprnfdiFVLNDQQktltARAKVILNwvhdggvlligYELFRllalKLVKTRKRKGsVIRPDGMDSSSDL 550
Cdd:cd17995 73 -----TDMNV-------VVYHGSG----ESRQIIQQ-----------YEMYF----KDAQGRKKKG-VYKFDVLITTYEM 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 551 MNLVYEALVKPGPDLVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTEFCNMF 630
Cdd:cd17995 121 VIADAEELRKIPWRVVVVDEAHRLKNRNSKLLQGLKKLTLEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEF 200
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
422-668 |
2.20e-24 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 103.17 E-value: 2.20e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 422 ILAHSMGLGKTLQVVSFCDiFLRHTSAKT--VLCVMPINTLQNWLSEFNMWIPrystdsnvrprNFDIFVLNDQQKTlta 499
Cdd:cd17997 26 ILADEMGLGKTLQTISLLG-YLKHYKNINgpHLIIVPKSTLDNWMREFKRWCP-----------SLRVVVLIGDKEE--- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 500 RAKVILNWVHDG--GVLLIGYELfrllalklvktrkrkgsVIRpdgmdSSSDLMNLVYEALvkpgpdlvICDEGHRIKNS 577
Cdd:cd17997 91 RADIIRDVLLPGkfDVCITSYEM-----------------VIK-----EKTVLKKFNWRYI--------IIDEAHRIKNE 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 578 HAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTEFCNMFErpiqngqcVDSTPDDIKLMRYRahvL 657
Cdd:cd17997 141 KSKLSQIVRLFNSRNRLLLTGTPLQNNLHELWALLNFLLPDVFTSSEDFDEWFN--------VNNCDDDNQEVVQR---L 209
|
250
....*....|.
gi 62484263 658 HSLLLGFVQRR 668
Cdd:cd17997 210 HKVLRPFLLRR 220
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
413-626 |
2.40e-23 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 100.12 E-value: 2.40e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 413 YNKSSGFGCILAHSMGLGKTLQVVSFCDiFLRHTS--AKTVLCVMPINTLQNWLSEFNMWIPrystDSNVrprnfdIFVL 490
Cdd:cd17993 15 HSWCKGNNGILADEMGLGKTVQTISFLS-YLFHSQqqYGPFLVVVPLSTMPAWQREFAKWAP----DMNV------IVYL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 491 NDQQKTLTARAkviLNWVHDGG------VLLIGYELfrllalkLVKTRkrkgsvirpdgmdssSDLMNLVYEALvkpgpd 564
Cdd:cd17993 84 GDIKSRDTIRE---YEFYFSQTkklkfnVLLTTYEI-------ILKDK---------------AFLGSIKWQYL------ 132
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62484263 565 LVicDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTEF 626
Cdd:cd17993 133 AV--DEAHRLKNDESLLYEALKEFKTNNRLLITGTPLQNSLKELWALLHFLMPGKFDIWEEF 192
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
390-668 |
7.02e-23 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 99.38 E-value: 7.02e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 390 VIKPHQIGGV---RFLYDNiiestrrynkssGFGCILAHSMGLGKTLQVVSFCDIFLRHTSAKTVLCVMPINTLQNWLSE 466
Cdd:cd18009 3 VMRPYQLEGMewlRMLWEN------------GINGILADEMGLGKTIQTIALLAHLRERGVWGPFLVIAPLSTLPNWVNE 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 467 FNMWIPrystdsnvrprnfDIFVL-----NDQQKTLtARAKVILNWVHDG-GVLLIGYELFRllalklvktRKRKgsvir 540
Cdd:cd18009 71 FARFTP-------------SVPVLlyhgtKEERERL-RKKIMKREGTLQDfPVVVTSYEIAM---------RDRK----- 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 541 pdgmdsssdlmnlvyeALVKPGPDLVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYL 620
Cdd:cd18009 123 ----------------ALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRLLLTGTPLQNNLSELWSLLNFLLPDVF 186
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 62484263 621 GTRTEFCNMFERPIQNGQCVDSTPDDIKLMRYRAHVLHSLLLGFVQRR 668
Cdd:cd18009 187 DDLSSFESWFDFSSLSDNAADISNLSEEREQNIVHMLHAILKPFLLRR 234
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
391-618 |
9.36e-21 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 91.68 E-value: 9.36e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 391 IKPHQIGGVRFLydniiesTRRYNKssGFGCILAHSMGLGKTLQVVSFCDIFLRHTSAKTVLCVMPINTLQNWLSEFNMW 470
Cdd:cd17998 1 LKDYQLIGLNWL-------NLLYQK--KLSGILADEMGLGKTIQVIAFLAYLKEIGIPGPHLVVVPSSTLDNWLREFKRW 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 471 IPRYstdsNVRPrnfdIFVLNDQQKTLTARakvILNWVHDGGVLLIGYELfrllalklvktrkrkgsVIRPDGMDSSSDL 550
Cdd:cd17998 72 CPSL----KVEP----YYGSQEERKHLRYD---ILKGLEDFDVIVTTYNL-----------------ATSNPDDRSFFKR 123
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62484263 551 MNLvyealvkpgpDLVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPN 618
Cdd:cd17998 124 LKL----------NYVVYDEGHMLKNMTSERYRHLMTINANFRLLLTGTPLQNNLLELMSLLNFIMPK 181
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
962-1085 |
2.05e-20 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 88.04 E-value: 2.05e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 962 KMEIFFCILKEslNLGDRILLFSQS--LLTLNLLevylkssyvpgsnqLWTKNSSYFRLDGSTSSQERERLVNEFNANSn 1039
Cdd:pfam00271 2 KLEALLELLKK--ERGGKVLIFSQTkkTLEAELL--------------LEKEGIKVARLHGDLSQEEREEILEDFRKGK- 64
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 62484263 1040 vKLFLISTRAGSLGINLTGANRVIIFDASWNPCHDTQAVYRIYRYG 1085
Cdd:pfam00271 65 -IDVLVATDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
422-668 |
4.89e-20 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 91.22 E-value: 4.89e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 422 ILAHSMGLGKTLQVVSFCD-IFLRHTSAKTVLCVMPINTLQNWLSEFNMWIPrystDSNVrprnfdIFVLNDQQKTLTAR 500
Cdd:cd18054 43 ILADEMGLGKTIQTISFLSyLFHQHQLYGPFLLVVPLSTLTSWQREFEIWAP----EINV------VVYIGDLMSRNTIR 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 501 AkviLNWVHDG------GVLLIGYELfrllalkLVKTRKRKGSVirpdgmdsssdlmNLVYEALvkpgpdlvicDEGHRI 574
Cdd:cd18054 113 E---YEWIHSQtkrlkfNALITTYEI-------LLKDKTVLGSI-------------NWAFLGV----------DEAHRL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 575 KNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNylgtRTEFCNMFERpiQNGQCVDSTpddiklmrYRA 654
Cdd:cd18054 160 KNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPE----KFEFWEDFEE--DHGKGRENG--------YQS 225
|
250
....*....|....
gi 62484263 655 hvLHSLLLGFVQRR 668
Cdd:cd18054 226 --LHKVLEPFLLRR 237
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
417-680 |
1.53e-19 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 89.72 E-value: 1.53e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 417 SGFGCILAHSMGLGKTLQVVSFCDiFLRHTS--AKTVLCVMPINTLQNWLSEFNMWIPRYSTdsnvrprnfdIFVLNDQQ 494
Cdd:cd18064 33 NGINGILADEMGLGKTLQTISLLG-YMKHYRniPGPHMVLVPKSTLHNWMAEFKRWVPTLRA----------VCLIGDKD 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 495 KTLTARAKVILNWVHDggVLLIGYELfrllalkLVKTRkrkgSVIRPdgmdsssdlMNLVYealvkpgpdlVICDEGHRI 574
Cdd:cd18064 102 QRAAFVRDVLLPGEWD--VCVTSYEM-------LIKEK----SVFKK---------FNWRY----------LVIDEAHRI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 575 KNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTEFCNMFErpiqNGQCVdstpDDIKLMRYra 654
Cdd:cd18064 150 KNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWFD----TNNCL----GDQKLVER-- 219
|
250 260
....*....|....*....|....*.
gi 62484263 655 hvLHSLLLGFVQRRSHTVLQLTLPQK 680
Cdd:cd18064 220 --LHMVLRPFLLRRIKADVEKSLPPK 243
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
391-668 |
1.16e-18 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 86.34 E-value: 1.16e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 391 IKPHQIGGVRFLydniieSTRRYNkssGFGCILAHSMGLGKTLQVVSFCdIFLRHTSAKT----VLCvmPINTLQNWLSE 466
Cdd:cd18006 1 LRPYQLEGVNWL------LQCRAE---QHGCILGDEMGLGKTCQTISLL-WYLAGRLKLLgpflVLC--PLSVLDNWKEE 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 467 FNMWIPRYSTdsnvrprnfdIFVLNDQQKTLTARA--KVILNWvhdgGVLLIGYELfrllALKlvktrkrkgsvirpdgm 544
Cdd:cd18006 69 LNRFAPDLSV----------ITYMGDKEKRLDLQQdiKSTNRF----HVLLTTYEI----CLK----------------- 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 545 dSSSDLMNLVYEALVkpgpdlviCDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRT 624
Cdd:cd18006 114 -DASFLKSFPWASLV--------VDEAHRLKNQNSLLHKTLSEFSVDFRLLLTGTPIQNSLQELYALLSFIEPNVFPKDK 184
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 62484263 625 --EFCNMFERpiqngqcvdsTPDDIKLmryrAHVLHSLLLGFVQRR 668
Cdd:cd18006 185 ldDFIKAYSE----------TDDESET----VEELHLLLQPFLLRR 216
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
1014-1085 |
1.89e-18 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 81.49 E-value: 1.89e-18
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62484263 1014 SYFRLDGSTSSQERERLVNEFNANSNVklFLISTRAGSLGINLTGANRVIIFDASWNPCHDTQAVYRIYRYG 1085
Cdd:smart00490 13 KVARLHGGLSQEEREEILDKFNNGKIK--VLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
417-668 |
1.03e-17 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 84.30 E-value: 1.03e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 417 SGFGCILAHSMGLGKTLQVVSFCDiFLRHTS--AKTVLCVMPINTLQNWLSEFNMWIPRystdsnvrprnfdifvlndqq 494
Cdd:cd18065 33 NGVNGILADEMGLGKTLQTIALLG-YLKHYRniPGPHMVLVPKSTLHNWMNEFKRWVPS--------------------- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 495 ktltarakvilnwvhdggvlligyelfrLLALKLVKTRKRKGSVIRPDGMDSSSDLMNLVYEALVKPGP-------DLVI 567
Cdd:cd18065 91 ----------------------------LRAVCLIGDKDARAAFIRDVMMPGEWDVCVTSYEMVIKEKSvfkkfnwRYLV 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 568 CDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTEFCNMFErpiqNGQCVdstpDDI 647
Cdd:cd18065 143 IDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFD----TKNCL----GDQ 214
|
250 260
....*....|....*....|.
gi 62484263 648 KLMRYrahvLHSLLLGFVQRR 668
Cdd:cd18065 215 KLVER----LHAVLKPFLLRR 231
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
390-668 |
2.23e-17 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 83.56 E-value: 2.23e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 390 VIKPHQIGGVRFLydniiesTRRYNKSsgFGCILAHSMGLGKTLQVVSFCDIFLRHTSAK-TVLCVMPINTLQNWLSEFN 468
Cdd:cd18062 23 VLKQYQIKGLEWL-------VSLYNNN--LNGILADEMGLGKTIQTIALITYLMEHKRINgPFLIIVPLSTLSNWVYEFD 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 469 MWIPRystdsnvrprnfdifVLNDQQKTLTARAKVILNWVHDG--GVLLIGYELfrllalkLVKTRkrkgsvirpdgmds 546
Cdd:cd18062 94 KWAPS---------------VVKVSYKGSPAARRAFVPQLRSGkfNVLLTTYEY-------IIKDK-------------- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 547 ssdlmnlvyEALVKPGPDLVICDEGHRIKNSHAGISLALK-EIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTE 625
Cdd:cd18062 138 ---------QILAKIRWKYMIVDEGHRMKNHHCKLTQVLNtHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCST 208
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 62484263 626 FCNMFERPI-QNGQCVDSTPDDIKLMRYRahvLHSLLLGFVQRR 668
Cdd:cd18062 209 FEQWFNAPFaMTGEKVDLNEEETILIIRR---LHKVLRPFLLRR 249
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
422-668 |
3.64e-17 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 83.19 E-value: 3.64e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 422 ILAHSMGLGKTLQVVSFCDIFLRHTSAK-TVLCVMPINTLQNWLSEFNMWIPRystdsnvrprnfdifVLNDQQKTLTAR 500
Cdd:cd18063 46 ILADEMGLGKTIQTIALITYLMEHKRLNgPYLIIVPLSTLSNWTYEFDKWAPS---------------VVKISYKGTPAM 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 501 AKVILNWVHDG--GVLLIGYELFRLLALKLVKTRKRkgsvirpdgmdsssdlmnlvyealvkpgpdLVICDEGHRIKNSH 578
Cdd:cd18063 111 RRSLVPQLRSGkfNVLLTTYEYIIKDKHILAKIRWK------------------------------YMIVDEGHRMKNHH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 579 AGISLALK-EIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTEFCNMFERPI-QNGQCVDSTPDDIKLMRYRahv 656
Cdd:cd18063 161 CKLTQVLNtHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFaMTGERVDLNEEETILIIRR--- 237
|
250
....*....|..
gi 62484263 657 LHSLLLGFVQRR 668
Cdd:cd18063 238 LHKVLRPFLLRR 249
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
422-668 |
5.46e-17 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 81.63 E-value: 5.46e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 422 ILAHSMGLGKTLQVVSFcdifLRH-TSAKTV----LCVMPINTLQNWLSEFNMWIPrystdsnvrprNFDIFVLNDQQKT 496
Cdd:cd18003 23 ILADEMGLGKTIQTIAL----LAHlACEKGNwgphLIVVPTSVMLNWEMEFKRWCP-----------GFKILTYYGSAKE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 497 ltaRAKVILNWVHDGG--VLLIGYELFrlLALKLVKTRKRKGSVIrpdgmdsssdlmnlvyealvkpgpdlviCDEGHRI 574
Cdd:cd18003 88 ---RKLKRQGWMKPNSfhVCITSYQLV--VQDHQVFKRKKWKYLI----------------------------LDEAHNI 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 575 KNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTEFCNMFERPIqNGQCVDSTPDDIKLMRYra 654
Cdd:cd18003 135 KNFKSQRWQTLLNFNTQRRLLLTGTPLQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNPL-TAMSEGSQEENEELVRR-- 211
|
250
....*....|....
gi 62484263 655 hvLHSLLLGFVQRR 668
Cdd:cd18003 212 --LHKVLRPFLLRR 223
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
393-631 |
6.41e-17 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 80.95 E-value: 6.41e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 393 PHQIGGVRFLydniiestrRYNKSSGFGCILAHSMGLGKTLQVVSFC-DIFLRHTSAKTVLCVMPINTLQNWLSEFNMWI 471
Cdd:cd17994 3 PYQLEGLNWL---------RFSWAQGTDTILADEMGLGKTIQTIVFLySLYKEGHSKGPFLVSAPLSTIINWEREFEMWA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 472 PrystdsnvrprnfDIFVlndqqktltarakviLNWVHDgGVLLIGYELFrllalklvktrkrkgsvirpdGMDSSSdLM 551
Cdd:cd17994 74 P-------------DFYV---------------VTYVGD-HVLLTSYELI---------------------SIDQAI-LG 102
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 552 NLVYEALVkpgpdlviCDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTEFCNMFE 631
Cdd:cd17994 103 SIDWAVLV--------VDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLQGFLEEFA 174
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
391-640 |
2.69e-15 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 77.02 E-value: 2.69e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 391 IKPHQIGGVRFLYDNIiestrrYNKSSgfgCILAHSMGLGKTLQVVSFCDIFLRHTSAKTVLCVMPINTLQNWLSEFNMW 470
Cdd:cd18060 1 LREYQLEGVNWLLFNW------YNRQN---CILADEMGLGKTIQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTW 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 471 iprysTDSNVRPrnfdifvlndQQKTLTARAkvilnwvhdggvLLIGYELFrllalklvkTRKRKGSVIrPDGMdsSSDL 550
Cdd:cd18060 72 -----TEMNTIV----------YHGSLASRQ------------MIQQYEMY---------CKDSRGRLI-PGAY--KFDA 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 551 MNLVYEALVKPGPDL-------VICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTR 623
Cdd:cd18060 113 LITTFEMILSDCPELreiewrcVIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSE 192
|
250 260
....*....|....*....|..
gi 62484263 624 TEFCNMF-----ERPIQNGQCV 640
Cdd:cd18060 193 SEFLKDFgdlktEEQVQKLQAI 214
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
392-626 |
3.72e-15 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 77.01 E-value: 3.72e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 392 KPHQIGGVRFL--YDNIIESTRRYNKS--SGFGCILAHSMGLGKTLQVVSFCD-IFLRHTSAKTVLCVMPINTLQNWLSE 466
Cdd:cd18053 9 QPSYIGGHEGLelRDYQLNGLNWLAHSwcKGNSCILADEMGLGKTIQTISFLNyLFHEHQLYGPFLLVVPLSTLTSWQRE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 467 FNMWIPR-----YSTDSNVRprnfDIFVLNDQQKTLTARAKVilnwvhdgGVLLIGYELFrllalklvktrkrkgsvirp 541
Cdd:cd18053 89 IQTWAPQmnavvYLGDINSR----NMIRTHEWMHPQTKRLKF--------NILLTTYEIL-------------------- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 542 dgMDSSSDLMNLVYEalvkpgpdLVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLG 621
Cdd:cd18053 137 --LKDKSFLGGLNWA--------FIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFS 206
|
....*
gi 62484263 622 TRTEF 626
Cdd:cd18053 207 SWEDF 211
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
391-668 |
3.90e-15 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 76.39 E-value: 3.90e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 391 IKPHQIGGVRFLYdNIIEStrrynkssGFGCILAHSMGLGKTLQVVSF-CDIFLRHTSAKTVLCVMPINTLQNWLSEFNM 469
Cdd:cd18002 1 LKEYQLKGLNWLA-NLYEQ--------GINGILADEMGLGKTVQSIAVlAHLAEEHNIWGPFLVIAPASTLHNWQQEISR 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 470 WIPRYST--------DSNVRPRNFDifvlndqQKTLTARakvilnwvhDGG--VLLIGYELfrllALKLVKTRKRkgsvi 539
Cdd:cd18002 72 FVPQFKVlpywgnpkDRKVLRKFWD-------RKNLYTR---------DAPfhVVITSYQL----VVQDEKYFQR----- 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 540 rpdgmdsssdlMNLVYealvkpgpdlVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNY 619
Cdd:cd18002 127 -----------VKWQY----------MVLDEAQAIKSSSSSRWKTLLSFHCRNRLLLTGTPIQNSMAELWALLHFIMPTL 185
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 62484263 620 LGTRTEFCNMFERPIQNGQCVDSTPDDIKLMRyrahvLHSLLLGFVQRR 668
Cdd:cd18002 186 FDSHDEFNEWFSKDIESHAENKTGLNEHQLKR-----LHMILKPFMLRR 229
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
391-630 |
4.52e-15 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 76.64 E-value: 4.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 391 IKPHQIGGVRFLydniiestrRYNKSSGFGCILAHSMGLGKTLQVVSFC-DIFLRHTSAKTVLCVMPINTLQNWLSEFNM 469
Cdd:cd18057 1 LHPYQLEGLNWL---------RFSWAQGTDTILADEMGLGKTVQTIVFLySLYKEGHSKGPYLVSAPLSTIINWEREFEM 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 470 WIPRYstdsnvrprnFDIFVLNDQQKTLTARAKvilNWVHDGGVLLIGYELFRLlalklvktrkRKGSVIRPDGMDSSSD 549
Cdd:cd18057 72 WAPDF----------YVVTYTGDKESRSVIREN---EFSFEDNAIRSGKKVFRM----------KKEAQIKFHVLLTSYE 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 550 LMNLVYEALVKPGPDLVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTEFCNM 629
Cdd:cd18057 129 LITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEE 208
|
.
gi 62484263 630 F 630
Cdd:cd18057 209 F 209
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
391-630 |
5.07e-15 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 76.23 E-value: 5.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 391 IKPHQIGGVRFLYDNIiestrrYNKSSgfgCILAHSMGLGKTLQVVSFC-DIFLRHTSAKtVLCVMPINTLQNWLSEFNM 469
Cdd:cd18058 1 LREYQLEGMNWLLFNW------YNRKN---CILADEMGLGKTIQSITFLsEIFLMGIRGP-FLIIAPLSTITNWEREFRT 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 470 WiprysTDSNVrprnfdiFVLNDQQKTLTarakvilnwvhdggvLLIGYELFRllalklvktRKRKGSVIrpDGMDSSSD 549
Cdd:cd18058 71 W-----TEMNA-------IVYHGSQISRQ---------------MIQQYEMYY---------RDEQGNPL--SGIFKFQV 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 550 LMNlVYEALVKPGPDL-------VICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGT 622
Cdd:cd18058 113 VIT-TFEMILADCPELkkinwscVIIDEAHRLKNRNCKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPS 191
|
....*...
gi 62484263 623 RTEFCNMF 630
Cdd:cd18058 192 ETTFLEEF 199
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
419-668 |
1.92e-14 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 74.63 E-value: 1.92e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 419 FGCILAHSMGLGKTLQVVS------------------FCDIFLRHTSAKTVLCVMPINTLQNWLSEFNMwiprystdsNV 480
Cdd:cd18008 15 RGGILADEMGLGKTIQALAlilatrpqdpkipeeleeNSSDPKKLYLSKTTLIVVPLSLLSQWKDEIEK---------HT 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 481 RPRNFDIFVLNDQQKTLTAraKVILNwvHDggVLLIGYELFRllalKLVKTRKRKGSviRPDGMDSSSDLMNLVYEAlvk 560
Cdd:cd18008 86 KPGSLKVYVYHGSKRIKSI--EELSD--YD--IVITTYGTLA----SEFPKNKKGGG--RDSKEKEASPLHRIRWYR--- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 561 pgpdlVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGtrtefcnmfERPIQNGQCV 640
Cdd:cd18008 151 -----VILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFG---------DYPWFNSDIS 216
|
250 260
....*....|....*....|....*...
gi 62484263 641 DSTPDDIKLMRYRahvLHSLLLGFVQRR 668
Cdd:cd18008 217 KPFSKNDRKALER---LQALLKPILLRR 241
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
412-630 |
2.30e-14 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 74.28 E-value: 2.30e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 412 RYNKSSGFGCILAHSMGLGKTLQVVSFC-DIFLRHTSAKTVLCVMPINTLQNWLSEFNMWIPR-----YSTDSNVRP--- 482
Cdd:cd18055 13 RFSWAQGTDTILADEMGLGKTIQTIVFLySLYKEGHTKGPFLVSAPLSTIINWEREFQMWAPDfyvvtYTGDKDSRAiir 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 483 ---RNFDIFVLNDQQKTLTARAKVILNWvhdgGVLLIGYELFRLlalklvktrkrkgsvirpdgmdSSSDLMNLVYEALV 559
Cdd:cd18055 93 eneFSFDDNAVKGGKKAFKMKREAQVKF----HVLLTSYELVTI----------------------DQAALGSIRWACLV 146
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62484263 560 kpgpdlviCDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTEFCNMF 630
Cdd:cd18055 147 --------VDEAHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEF 209
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
391-630 |
4.03e-14 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 73.50 E-value: 4.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 391 IKPHQIGGVRFLYDNIiestrrYNKSSgfgCILAHSMGLGKTLQVVSFCDIFLRHTSAKTVLCVMPINTLQNWLSEFNMW 470
Cdd:cd18061 1 LREYQLEGLNWLLFNW------YNRRN---CILADEMGLGKTIQSITFLYEILLTGIRGPFLIIAPLSTIANWEREFRTW 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 471 iprysTDSNVrprnfdifvlndqqktltarakvilnWVHDGGV----LLIGYELFrllalklvkTRKRKGSVIRpdGMDS 546
Cdd:cd18061 72 -----TDLNV--------------------------VVYHGSLisrqMIQQYEMY---------FRDSQGRIIR--GAYR 109
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 547 SSDLMNlVYEALVKPGPDL-------VICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNY 619
Cdd:cd18061 110 FQAIIT-TFEMILGGCPELnaidwrcVIIDEAHRLKNKNCKLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLR 188
|
250
....*....|.
gi 62484263 620 LGTRTEFCNMF 630
Cdd:cd18061 189 FPSESTFMQEF 199
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
402-654 |
5.02e-14 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 73.66 E-value: 5.02e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 402 LYDNIIESTRRYNK-SSGFGCILAHSMGLGKTLQVVSFcdiflrhTSAKTVLCVMPINTLQNWLSEFnmwiprystDSNV 480
Cdd:cd18071 31 LFLNTITNFSQKKRpELVRGGILADDMGLGKTLTTISL-------ILANFTLIVCPLSVLSNWETQF---------EEHV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 481 RPRNFDIFVLNDQQKTLTARakvilnwvhdggvLLIGYELfrllalklVKTRKrkGSVIRPDGMDSSSDLMNLvyealvk 560
Cdd:cd18071 95 KPGQLKVYTYHGGERNRDPK-------------LLSKYDI--------VLTTY--NTLASDFGAKGDSPLHTI------- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 561 pGPDLVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTEFCNMFERPIQNGqcv 640
Cdd:cd18071 145 -NWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSLLSFLHLKPFSNPEYWRRLIQRPLTMG--- 220
|
250
....*....|....
gi 62484263 641 dstpDDIKLMRYRA 654
Cdd:cd18071 221 ----DPTGLKRLQV 230
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
391-630 |
1.42e-13 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 71.99 E-value: 1.42e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 391 IKPHQIGGVRFLYDNIiestrrYNKSSgfgCILAHSMGLGKTLQVVSFC-DIFLRHTSAKtVLCVMPINTLQNWLSEFNM 469
Cdd:cd18059 1 LREYQLEGVNWLLFNW------YNTRN---CILADEMGLGKTIQSITFLyEIYLKGIHGP-FLVIAPLSTIPNWEREFRT 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 470 WiprysTDSNVrprnfdIFVLNDQQKTLTARAkvilnwvhdggvlligYEL-FRLLALKLVKTRKRKGSVIRpdgmdsss 548
Cdd:cd18059 71 W-----TELNV------VVYHGSQASRRTIQL----------------YEMyFKDPQGRVIKGSYKFHAIIT-------- 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 549 dlmnlVYEALVKPGPDL-------VICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLG 621
Cdd:cd18059 116 -----TFEMILTDCPELrnipwrcVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFP 190
|
....*....
gi 62484263 622 TRTEFCNMF 630
Cdd:cd18059 191 SETTFMQEF 199
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
392-626 |
2.93e-13 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 70.70 E-value: 2.93e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 392 KPHQIGGVRFlydnIIESTRRynkssgfgCILAHSMGLGKTLQVVSFCDiFLRHtsAKTVLCVMPINTLQNWLSEFNMWI 471
Cdd:cd18010 2 LPFQREGVCF----ALRRGGR--------VLIADEMGLGKTVQAIAIAA-YYRE--EWPLLIVCPSSLRLTWADEIERWL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 472 PRYSTDsnvrprnfDIFVLNDQQKTLTarakvilnwVHDGGVLLIGYELFRLLALKLVKtrkRKGSVirpdgmdsssdlm 551
Cdd:cd18010 67 PSLPPD--------DIQVIVKSKDGLR---------DGDAKVVIVSYDLLRRLEKQLLA---RKFKV------------- 113
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62484263 552 nlvyealvkpgpdlVICDEGHRIKNSHAGISLALKEI--RTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTEF 626
Cdd:cd18010 114 --------------VICDESHYLKNSKAKRTKAALPLlkRAKRVILLSGTPALSRPIELFTQLDALDPKLFGRFHDF 176
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
391-629 |
9.71e-13 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 69.71 E-value: 9.71e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 391 IKPHQIGGVRFLydniiestrRYNKSSGFGCILAHSMGLGKTLQVVSFC-DIFLRHTSAKTVLCVMPINTLQNWLSEFNM 469
Cdd:cd18056 1 LHPYQLEGLNWL---------RFSWAQGTDTILADEMGLGKTVQTAVFLySLYKEGHSKGPFLVSAPLSTIINWEREFEM 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 470 WIPrystdsnvrprnfDIFVlndqqktltarakviLNWVHDGGVLLIGYE---LFRLLALKLVK--TRKRKGSVIRPDGM 544
Cdd:cd18056 72 WAP-------------DMYV---------------VTYVGDKDSRAIIREnefSFEDNAIRGGKkaSRMKKEASVKFHVL 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 545 DSSSDLMNLVYEALVKPGPDLVICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVRP----NYL 620
Cdd:cd18056 124 LTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPerfhNLE 203
|
....*....
gi 62484263 621 GTRTEFCNM 629
Cdd:cd18056 204 GFLEEFADI 212
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
393-650 |
1.78e-10 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 62.31 E-value: 1.78e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 393 PHQIGGVRFlydnIIESTRrynkssgFGCILAHSMGLGKTLQVVSFCDIFLRHTSAKTVLCVMPINTLQNWLSEFN--MW 470
Cdd:cd18011 3 PHQIDAVLR----ALRKPP-------VRLLLADEVGLGKTIEAGLIIKELLLRGDAKRVLILCPASLVEQWQDELQdkFG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 471 IPRYSTDSnvrprnfdifvlndqqKTLTARAKVILNWVHDGGVLLIGYELfrllalklvktrkrkgsvIRPDGMDSssdl 550
Cdd:cd18011 72 LPFLILDR----------------ETAAQLRRLIGNPFEEFPIVIVSLDL------------------LKRSEERR---- 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 551 mnlvyEALVKPGPDLVICDEGHRIKNSHAGIS----LALKEI--RTRRRIVLTGYPLQNNLLEYWCMVDFVRPNYlgtrt 624
Cdd:cd18011 114 -----GLLLSEEWDLVVVDEAHKLRNSGGGKEtkryKLGRLLakRARHVLLLTATPHNGKEEDFRALLSLLDPGR----- 183
|
250 260
....*....|....*....|....*.
gi 62484263 625 efcnmFERPIQNGQCVDSTPDDIKLM 650
Cdd:cd18011 184 -----FAVLGRFLRLDGLREVLAKVL 204
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
393-617 |
5.85e-09 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 57.89 E-value: 5.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 393 PHQIGGVRFLYDNIiestrrynkssgFGCILAHSMGLGKTLQVVSFCDIFLRHTSAKTVLCVMPINTL-QNWLSEFNMWI 471
Cdd:smart00487 11 PYQKEAIEALLSGL------------RDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELaEQWAEELKKLG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 472 PrystdsnvrPRNFDIFVLNDQQKTLTARAKVILNWVHdggVLLIGYE-LFRLLALKLVKTRKrkgsvirpdgmdsssdl 550
Cdd:smart00487 79 P---------SLGLKVVGLYGGDSKREQLRKLESGKTD---ILVTTPGrLLDLLENDKLSLSN----------------- 129
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62484263 551 mnlvyealvkpgPDLVICDEGHRIKNSHAG--ISLALKEIR-TRRRIVLTGYP---LQNNLLEYWCMVDFVRP 617
Cdd:smart00487 130 ------------VDLVILDEAHRLLDGGFGdqLEKLLKLLPkNVQLLLLSATPpeeIENLLELFLNDPVFIDV 190
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
420-616 |
1.54e-07 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 54.41 E-value: 1.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 420 GCILAHSMGLGKTLQVVS--FCDIFLRHTSAKTVLcvmpintlqnwlSEFNMWIPRysTDSNVRPRNFDIFVlndqqktl 497
Cdd:cd18072 22 GGILADDMGLGKTLTMIAliLAQKNTQNRKEEEKE------------KALTEWESK--KDSTLVPSAGTLVV-------- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484263 498 tARAKVILNWVHdggvlligyELFRLLALKLVK-------TRKRKGSVIRpdgmdsSSDLMNLVYEALVKPGPDL----- 565
Cdd:cd18072 80 -CPASLVHQWKN---------EVESRVASNKLRvclyhgpNRERIGEVLR------DYDIVITTYSLVAKEIPTYkeesr 143
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62484263 566 -----------VICDEGHRIKNSHAGISLALKEIRTRRRIVLTGYPLQNNLLEYWCMVDFVR 616
Cdd:cd18072 144 ssplfriawarIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLR 205
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
1021-1088 |
1.58e-06 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 47.31 E-value: 1.58e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62484263 1021 STSSQERERLVNEFNansnvklFLISTRAGSLGINLTGANRVIIFDASWNPCHDTQAVYRIYRYGQTK 1088
Cdd:cd18785 10 TNSIEHAEEIASSLE-------ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDE 70
|
|
| |
