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Conserved domains on  [gi|24762554|ref|NP_611881|]
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uncharacterized protein Dmel_CG10339 [Drosophila melanogaster]

Protein Classification

carboxylesterase/lipase family protein( domain architecture ID 10444481)

carboxylesterase/lipase family protein similar to carboxylesterase, which catalyzes the hydrolysis of a carboxylic ester to form an alcohol and a carboxylate

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
30-560 6.38e-179

Carboxylesterase family;


:

Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 516.09  E-value: 6.38e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554    30 DAPFIHIPgNGVISGTYLKMFRTQNIKAYLGIRYAHA----RRFQPPdIELTPWKGIFNATVFQPDCWQNAMPSVGKETE 105
Cdd:pfam00135   1 DSPVVTTS-LGRVRGKRLKVDGGKPVYAFLGIPYAEPpvgeLRFQPP-EPPEPWTGVRDATKFGPRCPQNGDLTSPGSSG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554   106 QilkiiqsdssaqdaerKYEENCLYLNVFVPDGLPEI-NGYAVVVWIHSGDFSTGSPADVEPFQLVFKQKVIVVTFSYRL 184
Cdd:pfam00135  79 L----------------EGSEDCLYLNVYTPKELKENkNKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRL 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554   185 NIFGFFTTDDGEAQGNYGLMDQSAALYWVKKNINFFGGDSNRITLMGHDAGAVSVALHMTSgEWSKGGFHKAIIMSGNPL 264
Cdd:pfam00135 143 GPLGFLSTGDDEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLS-PLSKGLFHRAILMSGSAL 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554   265 STVKMPYEYEGSLDQVSSTFACPRRPTSMFIQCLKRIDAKRLSEN---------LPQVSWGPVVDFGlsntsypFIENQP 335
Cdd:pfam00135 222 SPWAIQSNARQRAKELAKLVGCPTSDSAELVECLRSKPAEELLDAqlkllvygsVPFVPFGPVVDGD-------FLPEHP 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554   336 EILFKKGSYHRVPVIIGVTDMEEVLTLFKDNLDTDISPSDLEGFYTDIAVTDMHKLVRnyewcSNYELISDAINFMY-AN 414
Cdd:pfam00135 295 EELLKSGNFPKVPLLIGVTKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLLV-----DLPEEISAALREEYlDW 369
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554   415 DSDTDAKKANKHIISAHTEKFYITPMQTFADLISN-DSQVYSYLFRMRPRSVLQdlPSWISVPKYFDQIFVWGNPYMTNS 493
Cdd:pfam00135 370 GDRDDPETSRRALVELLTDYLFNCPVIRFADLHASrGTPVYMYSFDYRGSSLRY--PKWVGVDHGDELPYVFGTPFVGAL 447
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24762554   494 VDWKStDKKIADIIMTLWANFAKTSNPTKSNVYVKWNAMTPNNDSVLLIDESFNTDNLLNNQRINFW 560
Cdd:pfam00135 448 LFTEE-DEKLSRKMMTYWTNFAKTGNPNGPEGLPKWPPYTDENGQYLSIDLEPRVKQGLKAERCAFW 513
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
30-560 6.38e-179

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 516.09  E-value: 6.38e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554    30 DAPFIHIPgNGVISGTYLKMFRTQNIKAYLGIRYAHA----RRFQPPdIELTPWKGIFNATVFQPDCWQNAMPSVGKETE 105
Cdd:pfam00135   1 DSPVVTTS-LGRVRGKRLKVDGGKPVYAFLGIPYAEPpvgeLRFQPP-EPPEPWTGVRDATKFGPRCPQNGDLTSPGSSG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554   106 QilkiiqsdssaqdaerKYEENCLYLNVFVPDGLPEI-NGYAVVVWIHSGDFSTGSPADVEPFQLVFKQKVIVVTFSYRL 184
Cdd:pfam00135  79 L----------------EGSEDCLYLNVYTPKELKENkNKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRL 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554   185 NIFGFFTTDDGEAQGNYGLMDQSAALYWVKKNINFFGGDSNRITLMGHDAGAVSVALHMTSgEWSKGGFHKAIIMSGNPL 264
Cdd:pfam00135 143 GPLGFLSTGDDEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLS-PLSKGLFHRAILMSGSAL 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554   265 STVKMPYEYEGSLDQVSSTFACPRRPTSMFIQCLKRIDAKRLSEN---------LPQVSWGPVVDFGlsntsypFIENQP 335
Cdd:pfam00135 222 SPWAIQSNARQRAKELAKLVGCPTSDSAELVECLRSKPAEELLDAqlkllvygsVPFVPFGPVVDGD-------FLPEHP 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554   336 EILFKKGSYHRVPVIIGVTDMEEVLTLFKDNLDTDISPSDLEGFYTDIAVTDMHKLVRnyewcSNYELISDAINFMY-AN 414
Cdd:pfam00135 295 EELLKSGNFPKVPLLIGVTKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLLV-----DLPEEISAALREEYlDW 369
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554   415 DSDTDAKKANKHIISAHTEKFYITPMQTFADLISN-DSQVYSYLFRMRPRSVLQdlPSWISVPKYFDQIFVWGNPYMTNS 493
Cdd:pfam00135 370 GDRDDPETSRRALVELLTDYLFNCPVIRFADLHASrGTPVYMYSFDYRGSSLRY--PKWVGVDHGDELPYVFGTPFVGAL 447
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24762554   494 VDWKStDKKIADIIMTLWANFAKTSNPTKSNVYVKWNAMTPNNDSVLLIDESFNTDNLLNNQRINFW 560
Cdd:pfam00135 448 LFTEE-DEKLSRKMMTYWTNFAKTGNPNGPEGLPKWPPYTDENGQYLSIDLEPRVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
39-547 5.79e-100

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 312.73  E-value: 5.79e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554  39 NGVISGTYLKMFRtqnikAYLGIRYAH----ARRFQPPdIELTPWKGIFNATVFQPDCWQNAmpsvgketeqilkiiQSD 114
Cdd:cd00312   6 NGKVRGVDEGGVY-----SFLGIPYAEppvgDLRFKEP-QPYEPWSDVLDATSYPPSCMQWD---------------QLG 64
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554 115 SSAQDAERKYEENCLYLNVFVPDGLPEINGYAVVVWIHSGDFSTGSPADVEPFQLVFK-QKVIVVTFSYRLNIFGFFTTD 193
Cdd:cd00312  65 GGLWNAKLPGSEDCLYLNVYTPKNTKPGNSLPVMVWIHGGGFMFGSGSLYPGDGLAREgDNVIVVSINYRLGVLGFLSTG 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554 194 DGEAQGNYGLMDQSAALYWVKKNINFFGGDSNRITLMGHDAGAVSVALHMTSgEWSKGGFHKAIIMSGNPLSTVKMPYEY 273
Cdd:cd00312 145 DIELPGNYGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLS-PDSKGLFHRAISQSGSALSPWAIQENA 223
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554 274 EGSLDQVSSTFACPRRPTSMFIQCLKRIDAKRLSE---------NLPQVSWGPVVDfGlsntsyPFIENQPEILFKKGSY 344
Cdd:cd00312 224 RGRAKRLARLLGCNDTSSAELLDCLRSKSAEELLDatrklllfsYSPFLPFGPVVD-G------DFIPDDPEELIKEGKF 296
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554 345 HRVPVIIGVTDMEEvlTLFKdnldtdisPSDLEGFYTDIAVTDMHKL-VRNYEWCSNYELISDAINFMYaNDSDTDAKKA 423
Cdd:cd00312 297 AKVPLIIGVTKDEG--GYFA--------AMLLNFDAKLIIETNDRWLeLLPYLLFYADDALADKVLEKY-PGDVDDSVES 365
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554 424 NKHIISAHTEKFYITPMQTFADLIS--NDSQVYSYLFRMRPRSVLQDLPSWISVPKYFDQIFVWGNPYMtnSVDWKSTDK 501
Cdd:cd00312 366 RKNLSDMLTDLLFKCPARYFLAQHRkaGGSPVYAYVFDHRSSLSVGRWPPWLGTVHGDEIFFVFGNPLL--KEGLREEEE 443
                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*.
gi 24762554 502 KIADIIMTLWANFAKTSNPTKSNVYVKWNAMTPNNDSVLLIDESFN 547
Cdd:cd00312 444 KLSRTMMKYWANFAKTGNPNTEGNLVVWPAYTSESEKYLDINIEGT 489
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
30-564 3.91e-90

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 287.55  E-value: 3.91e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554  30 DAPFIHIPgNGVISGTylkmfRTQNIKAYLGIRYA----HARRFQPPDiELTPWKGIFNATVFQPDCWQNAMPSVGKETE 105
Cdd:COG2272  11 AAPVVRTE-AGRVRGV-----VEGGVRVFLGIPYAappvGELRWRAPQ-PVEPWTGVRDATEFGPACPQPPRPGDPGGPA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554 106 qilkiIQSdssaqdaerkyeENCLYLNVFVPD-----GLPeingyaVVVWIHSGDFSTGSPADVE--PFQLVfKQKVIVV 178
Cdd:COG2272  84 -----PGS------------EDCLYLNVWTPAlaagaKLP------VMVWIHGGGFVSGSGSEPLydGAALA-RRGVVVV 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554 179 TFSYRLNIFGFF-----TTDDGEAQGNYGLMDQSAALYWVKKNINFFGGDSNRITLMGHDAGAVSVALHMTSGEwSKGGF 253
Cdd:COG2272 140 TINYRLGALGFLalpalSGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPL-AKGLF 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554 254 HKAIIMSGNPLSTVkmpyeyegSLDQ---VSSTFA----CPrrPTSmfIQCLKRIDAKRL--------SENLPQVSWGPV 318
Cdd:COG2272 219 HRAIAQSGAGLSVL--------TLAEaeaVGAAFAaalgVA--PAT--LAALRALPAEELlaaqaalaAEGPGGLPFGPV 286
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554 319 VDfGlsntsyPFIENQPEILFKKGSYHRVPVIIGVTDMEEVLTLFKDNLDTDISPSDLEgfytdiavtdmHKLVRNYEwc 398
Cdd:COG2272 287 VD-G------DVLPEDPLEAFAAGRAADVPLLIGTNRDEGRLFAALLGDLGPLTAADYR-----------AALRRRFG-- 346
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554 399 SNYELISDAinfmYANDSDTDAKKAnkhiisAHTEKFYITPMQTFADLISNDSQ-VYSYLF-RMRPRSVLQDLPSW--IS 474
Cdd:COG2272 347 DDADEVLAA----YPAASPAEALAA------LATDRVFRCPARRLAEAHAAAGApVYLYRFdWRSPPLRGFGLGAFhgAE 416
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554 475 VPkyfdqiFVWGNPYMTNSVDWKSTDKKIADIIMTLWANFAKTSNPTKSNVyVKWNAMTPNNDSVLLIDESFNTDNLLNN 554
Cdd:COG2272 417 LP------FVFGNLDAPALTGLTPADRALSDQMQAYWVNFARTGDPNGPGL-PEWPAYDPEDRAVMVFDAEPRVVNDPDA 489
                       570
                ....*....|.
gi 24762554 555 Q-RINFWRSLY 564
Cdd:COG2272 490 EeRLDLWDGVV 500
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
30-560 6.38e-179

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 516.09  E-value: 6.38e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554    30 DAPFIHIPgNGVISGTYLKMFRTQNIKAYLGIRYAHA----RRFQPPdIELTPWKGIFNATVFQPDCWQNAMPSVGKETE 105
Cdd:pfam00135   1 DSPVVTTS-LGRVRGKRLKVDGGKPVYAFLGIPYAEPpvgeLRFQPP-EPPEPWTGVRDATKFGPRCPQNGDLTSPGSSG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554   106 QilkiiqsdssaqdaerKYEENCLYLNVFVPDGLPEI-NGYAVVVWIHSGDFSTGSPADVEPFQLVFKQKVIVVTFSYRL 184
Cdd:pfam00135  79 L----------------EGSEDCLYLNVYTPKELKENkNKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRL 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554   185 NIFGFFTTDDGEAQGNYGLMDQSAALYWVKKNINFFGGDSNRITLMGHDAGAVSVALHMTSgEWSKGGFHKAIIMSGNPL 264
Cdd:pfam00135 143 GPLGFLSTGDDEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLS-PLSKGLFHRAILMSGSAL 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554   265 STVKMPYEYEGSLDQVSSTFACPRRPTSMFIQCLKRIDAKRLSEN---------LPQVSWGPVVDFGlsntsypFIENQP 335
Cdd:pfam00135 222 SPWAIQSNARQRAKELAKLVGCPTSDSAELVECLRSKPAEELLDAqlkllvygsVPFVPFGPVVDGD-------FLPEHP 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554   336 EILFKKGSYHRVPVIIGVTDMEEVLTLFKDNLDTDISPSDLEGFYTDIAVTDMHKLVRnyewcSNYELISDAINFMY-AN 414
Cdd:pfam00135 295 EELLKSGNFPKVPLLIGVTKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLLV-----DLPEEISAALREEYlDW 369
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554   415 DSDTDAKKANKHIISAHTEKFYITPMQTFADLISN-DSQVYSYLFRMRPRSVLQdlPSWISVPKYFDQIFVWGNPYMTNS 493
Cdd:pfam00135 370 GDRDDPETSRRALVELLTDYLFNCPVIRFADLHASrGTPVYMYSFDYRGSSLRY--PKWVGVDHGDELPYVFGTPFVGAL 447
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24762554   494 VDWKStDKKIADIIMTLWANFAKTSNPTKSNVYVKWNAMTPNNDSVLLIDESFNTDNLLNNQRINFW 560
Cdd:pfam00135 448 LFTEE-DEKLSRKMMTYWTNFAKTGNPNGPEGLPKWPPYTDENGQYLSIDLEPRVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
39-547 5.79e-100

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 312.73  E-value: 5.79e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554  39 NGVISGTYLKMFRtqnikAYLGIRYAH----ARRFQPPdIELTPWKGIFNATVFQPDCWQNAmpsvgketeqilkiiQSD 114
Cdd:cd00312   6 NGKVRGVDEGGVY-----SFLGIPYAEppvgDLRFKEP-QPYEPWSDVLDATSYPPSCMQWD---------------QLG 64
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554 115 SSAQDAERKYEENCLYLNVFVPDGLPEINGYAVVVWIHSGDFSTGSPADVEPFQLVFK-QKVIVVTFSYRLNIFGFFTTD 193
Cdd:cd00312  65 GGLWNAKLPGSEDCLYLNVYTPKNTKPGNSLPVMVWIHGGGFMFGSGSLYPGDGLAREgDNVIVVSINYRLGVLGFLSTG 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554 194 DGEAQGNYGLMDQSAALYWVKKNINFFGGDSNRITLMGHDAGAVSVALHMTSgEWSKGGFHKAIIMSGNPLSTVKMPYEY 273
Cdd:cd00312 145 DIELPGNYGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLS-PDSKGLFHRAISQSGSALSPWAIQENA 223
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554 274 EGSLDQVSSTFACPRRPTSMFIQCLKRIDAKRLSE---------NLPQVSWGPVVDfGlsntsyPFIENQPEILFKKGSY 344
Cdd:cd00312 224 RGRAKRLARLLGCNDTSSAELLDCLRSKSAEELLDatrklllfsYSPFLPFGPVVD-G------DFIPDDPEELIKEGKF 296
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554 345 HRVPVIIGVTDMEEvlTLFKdnldtdisPSDLEGFYTDIAVTDMHKL-VRNYEWCSNYELISDAINFMYaNDSDTDAKKA 423
Cdd:cd00312 297 AKVPLIIGVTKDEG--GYFA--------AMLLNFDAKLIIETNDRWLeLLPYLLFYADDALADKVLEKY-PGDVDDSVES 365
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554 424 NKHIISAHTEKFYITPMQTFADLIS--NDSQVYSYLFRMRPRSVLQDLPSWISVPKYFDQIFVWGNPYMtnSVDWKSTDK 501
Cdd:cd00312 366 RKNLSDMLTDLLFKCPARYFLAQHRkaGGSPVYAYVFDHRSSLSVGRWPPWLGTVHGDEIFFVFGNPLL--KEGLREEEE 443
                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*.
gi 24762554 502 KIADIIMTLWANFAKTSNPTKSNVYVKWNAMTPNNDSVLLIDESFN 547
Cdd:cd00312 444 KLSRTMMKYWANFAKTGNPNTEGNLVVWPAYTSESEKYLDINIEGT 489
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
30-564 3.91e-90

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 287.55  E-value: 3.91e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554  30 DAPFIHIPgNGVISGTylkmfRTQNIKAYLGIRYA----HARRFQPPDiELTPWKGIFNATVFQPDCWQNAMPSVGKETE 105
Cdd:COG2272  11 AAPVVRTE-AGRVRGV-----VEGGVRVFLGIPYAappvGELRWRAPQ-PVEPWTGVRDATEFGPACPQPPRPGDPGGPA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554 106 qilkiIQSdssaqdaerkyeENCLYLNVFVPD-----GLPeingyaVVVWIHSGDFSTGSPADVE--PFQLVfKQKVIVV 178
Cdd:COG2272  84 -----PGS------------EDCLYLNVWTPAlaagaKLP------VMVWIHGGGFVSGSGSEPLydGAALA-RRGVVVV 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554 179 TFSYRLNIFGFF-----TTDDGEAQGNYGLMDQSAALYWVKKNINFFGGDSNRITLMGHDAGAVSVALHMTSGEwSKGGF 253
Cdd:COG2272 140 TINYRLGALGFLalpalSGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPL-AKGLF 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554 254 HKAIIMSGNPLSTVkmpyeyegSLDQ---VSSTFA----CPrrPTSmfIQCLKRIDAKRL--------SENLPQVSWGPV 318
Cdd:COG2272 219 HRAIAQSGAGLSVL--------TLAEaeaVGAAFAaalgVA--PAT--LAALRALPAEELlaaqaalaAEGPGGLPFGPV 286
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554 319 VDfGlsntsyPFIENQPEILFKKGSYHRVPVIIGVTDMEEVLTLFKDNLDTDISPSDLEgfytdiavtdmHKLVRNYEwc 398
Cdd:COG2272 287 VD-G------DVLPEDPLEAFAAGRAADVPLLIGTNRDEGRLFAALLGDLGPLTAADYR-----------AALRRRFG-- 346
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554 399 SNYELISDAinfmYANDSDTDAKKAnkhiisAHTEKFYITPMQTFADLISNDSQ-VYSYLF-RMRPRSVLQDLPSW--IS 474
Cdd:COG2272 347 DDADEVLAA----YPAASPAEALAA------LATDRVFRCPARRLAEAHAAAGApVYLYRFdWRSPPLRGFGLGAFhgAE 416
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554 475 VPkyfdqiFVWGNPYMTNSVDWKSTDKKIADIIMTLWANFAKTSNPTKSNVyVKWNAMTPNNDSVLLIDESFNTDNLLNN 554
Cdd:COG2272 417 LP------FVFGNLDAPALTGLTPADRALSDQMQAYWVNFARTGDPNGPGL-PEWPAYDPEDRAVMVFDAEPRVVNDPDA 489
                       570
                ....*....|.
gi 24762554 555 Q-RINFWRSLY 564
Cdd:COG2272 490 EeRLDLWDGVV 500
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
133-250 1.32e-10

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 61.04  E-value: 1.32e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554 133 VFVPDGLPEinGYAVVVWIHSGDFSTGSPADVEPF--QLVFKQKVIVVTFSYRLNifgffttddGEAQGNYGLMDQSAAL 210
Cdd:COG0657   3 VYRPAGAKG--PLPVVVYFHGGGWVSGSKDTHDPLarRLAARAGAAVVSVDYRLA---------PEHPFPAALEDAYAAL 71
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 24762554 211 YWVKKNINFFGGDSNRITLMGHDAG---AVSVALHMTSGEWSK 250
Cdd:COG0657  72 RWLRANAAELGIDPDRIAVAGDSAGghlAAALALRARDRGGPR 114
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
139-261 1.67e-03

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 40.39  E-value: 1.67e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554 139 LPEING-YAVVVWIHSGDFSTgSPADVEPFQLVFKQKVIVVTFSYRlnifGFfttddGEAQGNYG---LMDQSAALYWVK 214
Cdd:COG1506  16 LPADGKkYPVVVYVHGGPGSR-DDSFLPLAQALASRGYAVLAPDYR----GY-----GESAGDWGgdeVDDVLAAIDYLA 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 24762554 215 KNinfFGGDSNRITLMGHDAGAVSVALHMTSgewSKGGFHKAIIMSG 261
Cdd:COG1506  86 AR---PYVDPDRIGIYGHSYGGYMALLAAAR---HPDRFKAAVALAG 126
BD-FAE pfam20434
BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, ...
145-236 3.67e-03

BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, previously known as bifunctional carbohydrate esterase (CE)), which is active on complex natural xylans and was identified as the basis of a monophyletic clade gathering all homologs identified in PULs (polysaccharide utilization loci) predicted to act on xylan. It adopts an alpha-beta-hydrolase fold with the catalytic triad Ser-Asp-His. This new family of proteins is a new candidate for biomass processing due to its capacity to remove ferulic acid and acetic acid from natural corn and birchwood xylan substrates.


Pssm-ID: 466583 [Multi-domain]  Cd Length: 215  Bit Score: 39.09  E-value: 3.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762554   145 YAVVVWIHSGDFSTGSPADVEPF-----QLVFKQKVIVVTFSYRL---NIFgffttddgEAQgnygLMDQSAALYWVKKN 216
Cdd:pfam20434  13 YPVVIWIHGGGWNSGDKEADMGFmtntvKALLKAGYAVASINYRLstdAKF--------PAQ----IQDVKAAIRFLRAN 80
                          90       100
                  ....*....|....*....|
gi 24762554   217 INFFGGDSNRITLMGHDAGA 236
Cdd:pfam20434  81 AAKYGIDTNKIALMGFSAGG 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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