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Conserved domains on  [gi|221468525|ref|NP_611879|]
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yorkie, isoform D [Drosophila melanogaster]

Protein Classification

WW domain-containing protein( domain architecture ID 10449603)

WW domain-containing protein; the WW domain mediates protein-protein interaction via proline-rich motifs, such as PPxY

CATH:  2.20.70.10
Gene Ontology:  GO:0005515
PubMed:  22201747|9029943|7641887

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 243-272 3.73e-13

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


:

Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 62.52  E-value: 3.73e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 221468525  243 LPPGWEQAKTNDGQIYYLNHTTKSTQWEDP 272
Cdd:pfam00397   1 LPPGWEERWDPDGRVYYYNHETGETQWEKP 30
 
Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 243-272 3.73e-13

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 62.52  E-value: 3.73e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 221468525  243 LPPGWEQAKTNDGQIYYLNHTTKSTQWEDP 272
Cdd:pfam00397   1 LPPGWEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 244-272 4.45e-13

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 62.55  E-value: 4.45e-13
                         10        20
                 ....*....|....*....|....*....
gi 221468525 244 PPGWEQAKTNDGQIYYLNHTTKSTQWEDP 272
Cdd:cd00201    1 PPGWEERWDPDGRVYYYNHNTKETQWEDP 29
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 243-272 7.16e-13

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 61.85  E-value: 7.16e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 221468525   243 LPPGWEQAKTNDGQIYYLNHTTKSTQWEDP 272
Cdd:smart00456   2 LPPGWEERKDPDGRPYYYNHETKETQWEKP 31
PRP40 COG5104
Splicing factor [RNA processing and modification];
247-298 2.69e-03

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 39.68  E-value: 2.69e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 221468525 247 WEQAKTNDGQIYYLNHTTKSTQWEDPRiqyrqqqqilmaERIKQNESGLSVL 298
Cdd:COG5104   17 WEELKAPDGRIYYYNKRTGKSSWEKPK------------ELLKGSEEDLDVD 56
 
Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 243-272 3.73e-13

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 62.52  E-value: 3.73e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 221468525  243 LPPGWEQAKTNDGQIYYLNHTTKSTQWEDP 272
Cdd:pfam00397   1 LPPGWEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 244-272 4.45e-13

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 62.55  E-value: 4.45e-13
                         10        20
                 ....*....|....*....|....*....
gi 221468525 244 PPGWEQAKTNDGQIYYLNHTTKSTQWEDP 272
Cdd:cd00201    1 PPGWEERWDPDGRVYYYNHNTKETQWEDP 29
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 243-272 7.16e-13

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 61.85  E-value: 7.16e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 221468525   243 LPPGWEQAKTNDGQIYYLNHTTKSTQWEDP 272
Cdd:smart00456   2 LPPGWEERKDPDGRPYYYNHETKETQWEKP 31
PRP40 COG5104
Splicing factor [RNA processing and modification];
247-298 2.69e-03

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 39.68  E-value: 2.69e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 221468525 247 WEQAKTNDGQIYYLNHTTKSTQWEDPRiqyrqqqqilmaERIKQNESGLSVL 298
Cdd:COG5104   17 WEELKAPDGRIYYYNKRTGKSSWEKPK------------ELLKGSEEDLDVD 56
PRP40 COG5104
Splicing factor [RNA processing and modification];
246-272 9.99e-03

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 37.75  E-value: 9.99e-03
                         10        20
                 ....*....|....*....|....*..
gi 221468525 246 GWEQAKTNDGQIYYLNHTTKSTQWEDP 272
Cdd:COG5104   57 PWKECRTADGKVYYYNSITRESRWKIP 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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