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Conserved domains on  [gi|1624699018|ref|NP_611808|]
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integrin alphaPS5 subunit [Drosophila melanogaster]

Protein Classification

integrin alpha( domain architecture ID 12028124)

integrin alpha forms a heterodimer with integrin beta to mediate cell-extracellular matrix and cell-cell interactions; integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions

Gene Ontology:  GO:0007155|GO:0008305|GO:0005178|GO:0046872
PubMed:  3028640|2199285|12297042|12826403|14689578|12361595|12234368

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 super family cl26747
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 453-837 2.26e-20

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


The actual alignment was detected with superfamily member pfam08441:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 95.47  E-value: 2.26e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624699018  453 PVVKIHATVRSESRAIRPEQET----------ITVTACyrLETTSKARQMQQQELTFRMTIDELLQ-----RVSFAPMRT 517
Cdd:pfam08441    2 PVVSVSASLQVEPNSINPEKKNctltgtpvscFTVRAC--FSYTGKPIPNPSLVLNYELELDRQKKkglppRVLFLDSQQ 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624699018  518 NEVSFQAQAGLSGS--CRNFSVgvhY----TGGIFTPIDLELHYELAKKiPHSHEAFCESCAVVDPLEPKYATGTLSFMT 591
Cdd:pfam08441   80 PSLTGTLVLLSQGRkvCRTTKA---YlrdeFRDKLSPIVISLNYSLRVD-PRAPSDLPGLKPILDQNQPSTVQEQANFLK 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624699018  592 GCAA-HVCVSDLQLSSK----DVNSSFIFGSLEVLSFSYEITNSGEPAYVAQFNVT-------SSARLPFAKVPGNCRVR 659
Cdd:pfam08441  156 DCGEdNVCVPDLQLSAKfdsrESDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTlppgldySGVRREGSEKQLSCTAK 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624699018  660 HE----VMLCDLngGRALARGDSESLTIIFDVTQLSGQ--SLTIEAAVSSAGmDQNPKDNTMSTTISLReyAEIDAS--- 730
Cdd:pfam08441  236 KEnstrQVVCDL--GNPMKRGTQVTFGLRFSVSGLELSteELSFDLQIRSTN-EQNSNSNPVSLKVPVV--AEAQLSlsg 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624699018  731 --------GGPIDGHiaLKEYPYSAE-----VNNSYEFKSHGPSIIDELTVYVDVPiaYTVTGSAGIKSIFNISSL-QMQ 796
Cdd:pfam08441  311 vskpdqvvGGSVKGE--SAMKPRSEEdigplVEHTYEVINNGPSTVSGASLEISWP--YELSNGKWLLYLLDVQGQgKGE 386

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|.
gi 1624699018  797 ATHGSELVPIKLyDQTNTLAKeyPLEDSSRRANRKRRELQQ 837
Cdd:pfam08441  387 CSPQNEINPLNL-TQSLESSK--PLRTSRVHHVVKRRDVLK 424
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 351-403 2.49e-14

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 68.17  E-value: 2.49e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1624699018   351 SGARFGSSLSKVGDINHDGYNDLAVGAPFAGN----GAVFIFLGSEHGLRDEPSQRL 403
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDagetGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 294-332 6.13e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


:

Pssm-ID: 460357  Cd Length: 36  Bit Score: 52.13  E-value: 6.13e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1624699018  294 FGYSVVAEDLNGDGLTDVVVSAPlnaLGDSYDVGAIYVF 332
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAP---GEGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 417-463 4.55e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 47.76  E-value: 4.55e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1624699018   417 MFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKIHATVRS 463
Cdd:smart00191    4 YFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSGGGN 50
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 453-837 2.26e-20

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 95.47  E-value: 2.26e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624699018  453 PVVKIHATVRSESRAIRPEQET----------ITVTACyrLETTSKARQMQQQELTFRMTIDELLQ-----RVSFAPMRT 517
Cdd:pfam08441    2 PVVSVSASLQVEPNSINPEKKNctltgtpvscFTVRAC--FSYTGKPIPNPSLVLNYELELDRQKKkglppRVLFLDSQQ 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624699018  518 NEVSFQAQAGLSGS--CRNFSVgvhY----TGGIFTPIDLELHYELAKKiPHSHEAFCESCAVVDPLEPKYATGTLSFMT 591
Cdd:pfam08441   80 PSLTGTLVLLSQGRkvCRTTKA---YlrdeFRDKLSPIVISLNYSLRVD-PRAPSDLPGLKPILDQNQPSTVQEQANFLK 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624699018  592 GCAA-HVCVSDLQLSSK----DVNSSFIFGSLEVLSFSYEITNSGEPAYVAQFNVT-------SSARLPFAKVPGNCRVR 659
Cdd:pfam08441  156 DCGEdNVCVPDLQLSAKfdsrESDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTlppgldySGVRREGSEKQLSCTAK 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624699018  660 HE----VMLCDLngGRALARGDSESLTIIFDVTQLSGQ--SLTIEAAVSSAGmDQNPKDNTMSTTISLReyAEIDAS--- 730
Cdd:pfam08441  236 KEnstrQVVCDL--GNPMKRGTQVTFGLRFSVSGLELSteELSFDLQIRSTN-EQNSNSNPVSLKVPVV--AEAQLSlsg 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624699018  731 --------GGPIDGHiaLKEYPYSAE-----VNNSYEFKSHGPSIIDELTVYVDVPiaYTVTGSAGIKSIFNISSL-QMQ 796
Cdd:pfam08441  311 vskpdqvvGGSVKGE--SAMKPRSEEdigplVEHTYEVINNGPSTVSGASLEISWP--YELSNGKWLLYLLDVQGQgKGE 386

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|.
gi 1624699018  797 ATHGSELVPIKLyDQTNTLAKeyPLEDSSRRANRKRRELQQ 837
Cdd:pfam08441  387 CSPQNEINPLNL-TQSLESSK--PLRTSRVHHVVKRRDVLK 424
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 351-403 2.49e-14

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 68.17  E-value: 2.49e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1624699018   351 SGARFGSSLSKVGDINHDGYNDLAVGAPFAGN----GAVFIFLGSEHGLRDEPSQRL 403
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDagetGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 294-332 6.13e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 52.13  E-value: 6.13e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1624699018  294 FGYSVVAEDLNGDGLTDVVVSAPlnaLGDSYDVGAIYVF 332
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAP---GEGGAGAGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 355-388 1.34e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 51.36  E-value: 1.34e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1624699018  355 FGSSLSkVGDINHDGYNDLAVGAPFA---GNGAVFIF 388
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEggaGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 291-334 2.60e-08

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 51.22  E-value: 2.60e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1624699018   291 GEYFGYSVV-AEDLNGDGLTDVVVSAPLNalGDSYDVGAIYVFIN 334
Cdd:smart00191    2 GSYFGYSVAgVGDVNGDGYPDLLVGAPRA--NDAGETGAVYVYFG 44
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 417-463 4.55e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 47.76  E-value: 4.55e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1624699018   417 MFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKIHATVRS 463
Cdd:smart00191    4 YFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSGGGN 50
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 418-449 7.92e-04

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 37.88  E-value: 7.92e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1624699018  418 FGQGLSRGsDIDGNGFNDLAIGAPG-----AEAVYLY 449
Cdd:pfam01839    1 FGYSVAVG-DLNGDGYADLAVGAPGeggagAGAVYVL 36
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 453-837 2.26e-20

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 95.47  E-value: 2.26e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624699018  453 PVVKIHATVRSESRAIRPEQET----------ITVTACyrLETTSKARQMQQQELTFRMTIDELLQ-----RVSFAPMRT 517
Cdd:pfam08441    2 PVVSVSASLQVEPNSINPEKKNctltgtpvscFTVRAC--FSYTGKPIPNPSLVLNYELELDRQKKkglppRVLFLDSQQ 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624699018  518 NEVSFQAQAGLSGS--CRNFSVgvhY----TGGIFTPIDLELHYELAKKiPHSHEAFCESCAVVDPLEPKYATGTLSFMT 591
Cdd:pfam08441   80 PSLTGTLVLLSQGRkvCRTTKA---YlrdeFRDKLSPIVISLNYSLRVD-PRAPSDLPGLKPILDQNQPSTVQEQANFLK 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624699018  592 GCAA-HVCVSDLQLSSK----DVNSSFIFGSLEVLSFSYEITNSGEPAYVAQFNVT-------SSARLPFAKVPGNCRVR 659
Cdd:pfam08441  156 DCGEdNVCVPDLQLSAKfdsrESDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTlppgldySGVRREGSEKQLSCTAK 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624699018  660 HE----VMLCDLngGRALARGDSESLTIIFDVTQLSGQ--SLTIEAAVSSAGmDQNPKDNTMSTTISLReyAEIDAS--- 730
Cdd:pfam08441  236 KEnstrQVVCDL--GNPMKRGTQVTFGLRFSVSGLELSteELSFDLQIRSTN-EQNSNSNPVSLKVPVV--AEAQLSlsg 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624699018  731 --------GGPIDGHiaLKEYPYSAE-----VNNSYEFKSHGPSIIDELTVYVDVPiaYTVTGSAGIKSIFNISSL-QMQ 796
Cdd:pfam08441  311 vskpdqvvGGSVKGE--SAMKPRSEEdigplVEHTYEVINNGPSTVSGASLEISWP--YELSNGKWLLYLLDVQGQgKGE 386

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|.
gi 1624699018  797 ATHGSELVPIKLyDQTNTLAKeyPLEDSSRRANRKRRELQQ 837
Cdd:pfam08441  387 CSPQNEINPLNL-TQSLESSK--PLRTSRVHHVVKRRDVLK 424
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 351-403 2.49e-14

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 68.17  E-value: 2.49e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1624699018   351 SGARFGSSLSKVGDINHDGYNDLAVGAPFAGN----GAVFIFLGSEHGLRDEPSQRL 403
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDagetGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 294-332 6.13e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 52.13  E-value: 6.13e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1624699018  294 FGYSVVAEDLNGDGLTDVVVSAPlnaLGDSYDVGAIYVF 332
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAP---GEGGAGAGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 355-388 1.34e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 51.36  E-value: 1.34e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1624699018  355 FGSSLSkVGDINHDGYNDLAVGAPFA---GNGAVFIF 388
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEggaGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 291-334 2.60e-08

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 51.22  E-value: 2.60e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1624699018   291 GEYFGYSVV-AEDLNGDGLTDVVVSAPLNalGDSYDVGAIYVFIN 334
Cdd:smart00191    2 GSYFGYSVAgVGDVNGDGYPDLLVGAPRA--NDAGETGAVYVYFG 44
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 302-375 7.59e-08

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 49.92  E-value: 7.59e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1624699018  302 DLNGDGLTDVVVSaplnalgdSYDVGAIYVFINKGLFKFEKKIIrlplSSGARFGSSLSkVGDINHDGYNDLAV 375
Cdd:pfam13517    1 DLDGDGKLDLVVA--------NDGGLRLYLNNGDGTFTFITSVS----LGGGGGGLSVA-VGDLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 417-463 4.55e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 47.76  E-value: 4.55e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1624699018   417 MFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKIHATVRS 463
Cdd:smart00191    4 YFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSGGGN 50
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 418-449 7.92e-04

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 37.88  E-value: 7.92e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1624699018  418 FGQGLSRGsDIDGNGFNDLAIGAPG-----AEAVYLY 449
Cdd:pfam01839    1 FGYSVAVG-DLNGDGYADLAVGAPGeggagAGAVYVL 36
DUF11 pfam01345
Domain of unknown function DUF11; A domain of unknown function found in multiple copies in ...
 665-719 4.84e-03

Domain of unknown function DUF11; A domain of unknown function found in multiple copies in several archaebacterial proteins. Conserved N-terminal lysine and C-terminal asparagine with central asp/glu suggests that many of these domain may contain an isopeptide bond. In Methanothermobacter sp. CaT2, a DUF11-containing repeat hypothetical protein encoded by MTCT_1020 plays a key role as a membrane-bound adhesion protein in the aggregation of CaT2. DUF11-containing repeat domains are not involved in aggregation, but may be important for stabilizing the surface cell wall structures of CaT2.


Pssm-ID: 460168 [Multi-domain]  Cd Length: 114  Bit Score: 37.97  E-value: 4.84e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1624699018  665 CDLNGGR----ALARGDSESLTIIFDVTqlSGQSLTIEAAVSSAGMDQNPKDNTMSTTI 719
Cdd:pfam01345   58 YDSATGIwtigSLAVGASATLTITATVN--TAGTITNTATVTSSTFDPNLSNNSASATV 114
FG-GAP_2 pfam14312
FG-GAP repeat;
291-332 5.23e-03

FG-GAP repeat;


Pssm-ID: 316802 [Multi-domain]  Cd Length: 49  Bit Score: 35.96  E-value: 5.23e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1624699018  291 GEYFGYSVvaeDLNGDGLtdvVVSAPLNALGDSyDVGAIYVF 332
Cdd:pfam14312   15 GDYFGWSV---AISGDTA---VVGAYGDDDNGS-NSGSAYVF 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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