vacuolar protein sorting 51 [Drosophila melanogaster]
Protein Classification
COG1/VPS51 family protein( domain architecture ID 10554766)
COG1/VPS51 family protein similar to Homo sapiens conserved oligomeric Golgi complex subunit 1 (COG1) and Schizosaccharomyces pombe vacuolar protein sorting-associated protein 51 (VPS51)
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| Vps51 | pfam08700 | Vps51/Vps67; This family includes a presumed domain found in a number of components of ... |
11-95 | 1.30e-19 | |||||
Vps51/Vps67; This family includes a presumed domain found in a number of components of vesicular transport. The VFT tethering complex (also known as GARP complex, Golgi associated retrograde protein complex, Vps53 tethering complex) is a conserved eukaryotic docking complex which is involved recycling of proteins from endosomes to the late Golgi. Vps51 (also known as Vps67) is a subunit of VFT and interacts with the SNARE Tlg1. Cog1_N is the N-terminus of the Cog1 subunit of the eight-unit Conserved Oligomeric Golgi (COG) complex that participates in retrograde vesicular transport and is required to maintain normal Golgi structure and function. The subunits are located in two lobes and Cog1 serves to bind the two lobes together probably via the highly conserved N-terminal domain of approximately 85 residues. : Pssm-ID: 462568 Cd Length: 86 Bit Score: 83.87 E-value: 1.30e-19
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| Cast super family | cl37807 | RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ... |
22-248 | 4.03e-03 | |||||
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains. The actual alignment was detected with superfamily member pfam10174: Pssm-ID: 431111 [Multi-domain] Cd Length: 766 Bit Score: 40.58 E-value: 4.03e-03
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| Name | Accession | Description | Interval | E-value | |||||
| Vps51 | pfam08700 | Vps51/Vps67; This family includes a presumed domain found in a number of components of ... |
11-95 | 1.30e-19 | |||||
Vps51/Vps67; This family includes a presumed domain found in a number of components of vesicular transport. The VFT tethering complex (also known as GARP complex, Golgi associated retrograde protein complex, Vps53 tethering complex) is a conserved eukaryotic docking complex which is involved recycling of proteins from endosomes to the late Golgi. Vps51 (also known as Vps67) is a subunit of VFT and interacts with the SNARE Tlg1. Cog1_N is the N-terminus of the Cog1 subunit of the eight-unit Conserved Oligomeric Golgi (COG) complex that participates in retrograde vesicular transport and is required to maintain normal Golgi structure and function. The subunits are located in two lobes and Cog1 serves to bind the two lobes together probably via the highly conserved N-terminal domain of approximately 85 residues. Pssm-ID: 462568 Cd Length: 86 Bit Score: 83.87 E-value: 1.30e-19
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| Cast | pfam10174 | RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ... |
22-248 | 4.03e-03 | |||||
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains. Pssm-ID: 431111 [Multi-domain] Cd Length: 766 Bit Score: 40.58 E-value: 4.03e-03
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| Name | Accession | Description | Interval | E-value | |||||
| Vps51 | pfam08700 | Vps51/Vps67; This family includes a presumed domain found in a number of components of ... |
11-95 | 1.30e-19 | |||||
Vps51/Vps67; This family includes a presumed domain found in a number of components of vesicular transport. The VFT tethering complex (also known as GARP complex, Golgi associated retrograde protein complex, Vps53 tethering complex) is a conserved eukaryotic docking complex which is involved recycling of proteins from endosomes to the late Golgi. Vps51 (also known as Vps67) is a subunit of VFT and interacts with the SNARE Tlg1. Cog1_N is the N-terminus of the Cog1 subunit of the eight-unit Conserved Oligomeric Golgi (COG) complex that participates in retrograde vesicular transport and is required to maintain normal Golgi structure and function. The subunits are located in two lobes and Cog1 serves to bind the two lobes together probably via the highly conserved N-terminal domain of approximately 85 residues. Pssm-ID: 462568 Cd Length: 86 Bit Score: 83.87 E-value: 1.30e-19
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| Sec5 | pfam15469 | Exocyst complex component Sec5; This entry represents the Sec5 component of the exocyst ... |
3-198 | 1.72e-10 | |||||
Exocyst complex component Sec5; This entry represents the Sec5 component of the exocyst complex which is an octomeric complex that mediates the tethering of post-Golgi secretory vesicles to the plasma membrane during exocytosis. Pssm-ID: 464733 Cd Length: 810 Bit Score: 64.69 E-value: 1.72e-10
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| COG2 | pfam06148 | COG (conserved oligomeric Golgi) complex component, COG2; The COG complex comprises eight ... |
16-139 | 4.54e-04 | |||||
COG (conserved oligomeric Golgi) complex component, COG2; The COG complex comprises eight proteins COG1-8. The COG complex plays critical roles in Golgi structure and function. The proposed function of the complex is to mediate the initial physical contact between transport vesicles and their membrane targets. A comparable role in tethering vesicles has been suggested for at least six additional large multisubunit complexes, including the exocyst, a complex that mediates trafficking to the plasma membrane. COG2 structure reveals a six-helix bundle with few conserved surface features but a general resemblance to recently determined crystal structures of four different exocyst subunits. These bundles inCOG2 may act as platforms for interaction with other trafficing proteins including SNAREs (soluble N-ethylmaleimide factor attachment protein receptors) and Rabs. Pssm-ID: 399271 Cd Length: 133 Bit Score: 40.71 E-value: 4.54e-04
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| Cast | pfam10174 | RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ... |
22-248 | 4.03e-03 | |||||
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains. Pssm-ID: 431111 [Multi-domain] Cd Length: 766 Bit Score: 40.58 E-value: 4.03e-03
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| Vps54_N | pfam10475 | Vacuolar-sorting protein 54, of GARP complex; This is a family of vacuolar-sorting proteins 54, ... |
16-189 | 6.50e-03 | |||||
Vacuolar-sorting protein 54, of GARP complex; This is a family of vacuolar-sorting proteins 54, from eukaryotes. Along with VPS52 and VPS53 this forms the Golgi-associated retrograde protein complex GARP. VPS54 is separated into N- and C-terminal regions each of which has a different function. This N-terminal family of is important for GARP complex assembly and stability, whereas the C-terminal domain, pfam07928, brings about localization to an early endocytic compartment. Pssm-ID: 431303 Cd Length: 291 Bit Score: 39.26 E-value: 6.50e-03
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