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Conserved domains on  [gi|19922488|ref|NP_611270|]
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uncharacterized protein Dmel_CG5033 [Drosophila melanogaster]

Protein Classification

WD repeat BOP1/ERB1 family ribosome biogenesis protein( domain architecture ID 10660079)

WD repeat BOP1/ERB1 family ribosome biogenesis protein is a component of a complex that is required for maturation of ribosomal RNAs and formation of the 60S ribosome

CATH:  2.130.10.10
Gene Ontology:  GO:0042254|GO:0003676|GO:0043021|GO:0006364
PubMed:  10322433|30069656|21468892
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BOP1NT smart01035
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 171-436 1.52e-155

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


:

Pssm-ID: 214986  Cd Length: 264  Bit Score: 452.93  E-value: 1.52e-155
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488    171 YDEYKHIGYDWDAKKIIKPPQGDQIDEFLRKIEDPDFWRTVKDPLTGQDVRLTDEDIALIKRIVSGRIPNKDHEEYEPWI 250
Cdd:smart01035   1 YDDYPHIGYDIDGKKIMKPAKGDALDKFLDSIDDPNFWRTVYDKQTGKDVNLTDEELELIKRIQRGEIPDENYDPYEPYV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488    251 EWFTSEVEKMPIKNVPDHKRSFLPSVSEKKRVSRMVHALKMGWMKTTEEVEREKQAKRGPKFYMLWETDTSREHMRRIHD 330
Cdd:smart01035  81 EWFTSEVEIMPLSNAPEPKRRFVPSKHEAKKIMKLVHAIRMGWIKPDKPPKEKEEEEEYPKFYDLWADEDETETKFRIIM 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488    331 PVSAPKRDLPGHAESYNPPPEYLFDAKETKEWLKLkdEPHKRKLHFMPQKFKSLREVPAYSRYLRERFLRCLDLYLCPRA 410
Cdd:smart01035 161 HIPAPKLPLPGHAESYNPPPEYLPTEEEKKEWEEL--EPEDRKLNFLPQKFDSLRKVPGYTNFIKERFERCLDLYLAPRQ 238

                          250       260
                   ....*....|....*....|....*.
gi 19922488    411 KRVKLNIDAEYLIPKLPSPRDLQPFP 436
Cdd:smart01035 239 RRNKLNIDPESLLPKLPSPKDLRPFP 264
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 442-783 8.11e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.86  E-value: 8.11e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 442 VYRGHTDLVRSVSVEPKGEYLVSGSDDKTVKIWEIATGRCIRTIET-DEVVRCVAWCPNPKLsiIAVATGNRLLLVnpkv 520
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhTGPVRDVAASADGTY--LASGSSDKTIRL---- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 521 gdkvlvkktddllaeapsqdvieseriktavqWSnaeaDEQEKGVRVVITHFKPIRQVTWHGRGDYLATVmpeGANRSAL 600
Cdd:cd00200  78 --------------------------------WD----LETGECVRTLTGHTSYVSSVAFSPDGRILSSS---SRDKTIK 118

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 601 IHQLSKRRSQIPFSKSKGLIQFVLFHPVKPcfFVATQHN---IRIYDLVKQELVKKLLTNSKWISGMSIHPKGDNLLVST 677
Cdd:cd00200 119 VWDVETGKCLTTLRGHTDWVNSVAFSPDGT--FVASSSQdgtIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSS 196

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 678 YDKK-MLWfdlDLST-KPYQTMRLHRNAVRSVAFHLRYPLFASGSDDQAVIvshgmVYNDLLQnpliVPLKKLQTHEKRd 755
Cdd:cd00200 197 SDGTiKLW---DLSTgKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIR-----VWDLRTG----ECVQTLSGHTNS- 263

                       330       340
                ....*....|....*....|....*...
gi 19922488 756 efgVLDVNWHPVQPWVFSTGADSTIRLY 783
Cdd:cd00200 264 ---VTSLAWSPDGKRLASGSADGTIRIW 288
 
Name Accession Description Interval E-value
BOP1NT smart01035
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 171-436 1.52e-155

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


Pssm-ID: 214986  Cd Length: 264  Bit Score: 452.93  E-value: 1.52e-155
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488    171 YDEYKHIGYDWDAKKIIKPPQGDQIDEFLRKIEDPDFWRTVKDPLTGQDVRLTDEDIALIKRIVSGRIPNKDHEEYEPWI 250
Cdd:smart01035   1 YDDYPHIGYDIDGKKIMKPAKGDALDKFLDSIDDPNFWRTVYDKQTGKDVNLTDEELELIKRIQRGEIPDENYDPYEPYV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488    251 EWFTSEVEKMPIKNVPDHKRSFLPSVSEKKRVSRMVHALKMGWMKTTEEVEREKQAKRGPKFYMLWETDTSREHMRRIHD 330
Cdd:smart01035  81 EWFTSEVEIMPLSNAPEPKRRFVPSKHEAKKIMKLVHAIRMGWIKPDKPPKEKEEEEEYPKFYDLWADEDETETKFRIIM 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488    331 PVSAPKRDLPGHAESYNPPPEYLFDAKETKEWLKLkdEPHKRKLHFMPQKFKSLREVPAYSRYLRERFLRCLDLYLCPRA 410
Cdd:smart01035 161 HIPAPKLPLPGHAESYNPPPEYLPTEEEKKEWEEL--EPEDRKLNFLPQKFDSLRKVPGYTNFIKERFERCLDLYLAPRQ 238

                          250       260
                   ....*....|....*....|....*.
gi 19922488    411 KRVKLNIDAEYLIPKLPSPRDLQPFP 436
Cdd:smart01035 239 RRNKLNIDPESLLPKLPSPKDLRPFP 264
BOP1NT pfam08145
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 171-436 1.63e-146

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


Pssm-ID: 462371  Cd Length: 259  Bit Score: 429.65  E-value: 1.63e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488   171 YDEYKHIGYDWDAKKIIKPPQGDQIDEFLRKIEDPDFWRTVKDPLTGQDVRLTDEDIALIKRIVSGRIPNKDHEEYEPWI 250
Cdd:pfam08145   1 YDDYPHIGYDIDGKKIMKPAKGDALDKFLDSMDDPNAWRTVYDKLTGKDVVLTDEDLELIRRIQKGEFPDAGYDPYEPYV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488   251 EWFTSEVEKMPIKNVPDHKRSFLPSVSEKKRVSRMVHALKMGWMKTTEEVEREkqakrgPKFYMLWETDTSREH-MRRIH 329
Cdd:pfam08145  81 EWFTSEDEIHPLSNAPEPKRRFIPSKWEAKKVMKLVRAIRMGRIKPRKPKEEE------PKFYDLWADEDETEEeRRRRP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488   330 DPVSAPKRDLPGHAESYNPPPEYLFDAKETKEWLKLkdEPHKRKLHFMPQKFKSLREVPAYSRYLRERFLRCLDLYLCPR 409
Cdd:pfam08145 155 DHIPAPKLPLPGHAESYNPPPEYLPTEEERKKWEEM--DPEDRKLNFLPQKYDSLRLVPAYEKFIKERFERCLDLYLCPR 232

                         250       260
                  ....*....|....*....|....*..
gi 19922488   410 AKRVKLNIDAEYLIPKLPSPRDLQPFP 436
Cdd:pfam08145 233 VRKNRLNIDPESLLPKLPSPKDLRPFP 259
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 442-783 8.11e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.86  E-value: 8.11e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 442 VYRGHTDLVRSVSVEPKGEYLVSGSDDKTVKIWEIATGRCIRTIET-DEVVRCVAWCPNPKLsiIAVATGNRLLLVnpkv 520
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhTGPVRDVAASADGTY--LASGSSDKTIRL---- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 521 gdkvlvkktddllaeapsqdvieseriktavqWSnaeaDEQEKGVRVVITHFKPIRQVTWHGRGDYLATVmpeGANRSAL 600
Cdd:cd00200  78 --------------------------------WD----LETGECVRTLTGHTSYVSSVAFSPDGRILSSS---SRDKTIK 118

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 601 IHQLSKRRSQIPFSKSKGLIQFVLFHPVKPcfFVATQHN---IRIYDLVKQELVKKLLTNSKWISGMSIHPKGDNLLVST 677
Cdd:cd00200 119 VWDVETGKCLTTLRGHTDWVNSVAFSPDGT--FVASSSQdgtIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSS 196

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 678 YDKK-MLWfdlDLST-KPYQTMRLHRNAVRSVAFHLRYPLFASGSDDQAVIvshgmVYNDLLQnpliVPLKKLQTHEKRd 755
Cdd:cd00200 197 SDGTiKLW---DLSTgKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIR-----VWDLRTG----ECVQTLSGHTNS- 263

                       330       340
                ....*....|....*....|....*...
gi 19922488 756 efgVLDVNWHPVQPWVFSTGADSTIRLY 783
Cdd:cd00200 264 ---VTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
442-783 1.45e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.80  E-value: 1.45e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 442 VYRGHTDLVRSVSVEPKGEYLVSGSDDKTVKIWEIATGRCIRTIET-DEVVRCVAWCPNPKLsiiaVATGnrlllvnpkv 520
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGhSGAVTSVAFSPDGKL----LASG---------- 180

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 521 gdkvlvkktddllaeapSQDvieseriKTAVQWSNAEADEqekgVRVVITHFKPIRQVTWHGRGDYLATVmpeGANRSAL 600
Cdd:COG2319 181 -----------------SDD-------GTVRLWDLATGKL----LRTLTGHTGAVRSVAFSPDGKLLASG---SADGTVR 229

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 601 IHQLSKRRSQIPFSKSKGLIQFVLFHPVKPCFFVATQHN-IRIYDLVKQELVKKLLTNSKWISGMSIHPKGDNLLVSTYD 679
Cdd:COG2319 230 LWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGtVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 680 KKMLWFDLDlSTKPYQTMRLHRNAVRSVAFHlryP---LFASGSDDQAVIVShgmvynDLLQNPLivpLKKLQTHEKrde 756
Cdd:COG2319 310 GTVRLWDLA-TGKLLRTLTGHTGAVRSVAFS---PdgkTLASGSDDGTVRLW------DLATGEL---LRTLTGHTG--- 373

                       330       340
                ....*....|....*....|....*..
gi 19922488 757 fGVLDVNWHPVQPWVFSTGADSTIRLY 783
Cdd:COG2319 374 -AVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 441-475 2.12e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 2.12e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 19922488    441 MVYRGHTDLVRSVSVEPKGEYLVSGSDDKTVKIWE 475
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
441-475 4.22e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.65  E-value: 4.22e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 19922488   441 MVYRGHTDLVRSVSVEPKGEYLVSGSDDKTVKIWE 475
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
BOP1NT smart01035
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 171-436 1.52e-155

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


Pssm-ID: 214986  Cd Length: 264  Bit Score: 452.93  E-value: 1.52e-155
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488    171 YDEYKHIGYDWDAKKIIKPPQGDQIDEFLRKIEDPDFWRTVKDPLTGQDVRLTDEDIALIKRIVSGRIPNKDHEEYEPWI 250
Cdd:smart01035   1 YDDYPHIGYDIDGKKIMKPAKGDALDKFLDSIDDPNFWRTVYDKQTGKDVNLTDEELELIKRIQRGEIPDENYDPYEPYV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488    251 EWFTSEVEKMPIKNVPDHKRSFLPSVSEKKRVSRMVHALKMGWMKTTEEVEREKQAKRGPKFYMLWETDTSREHMRRIHD 330
Cdd:smart01035  81 EWFTSEVEIMPLSNAPEPKRRFVPSKHEAKKIMKLVHAIRMGWIKPDKPPKEKEEEEEYPKFYDLWADEDETETKFRIIM 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488    331 PVSAPKRDLPGHAESYNPPPEYLFDAKETKEWLKLkdEPHKRKLHFMPQKFKSLREVPAYSRYLRERFLRCLDLYLCPRA 410
Cdd:smart01035 161 HIPAPKLPLPGHAESYNPPPEYLPTEEEKKEWEEL--EPEDRKLNFLPQKFDSLRKVPGYTNFIKERFERCLDLYLAPRQ 238

                          250       260
                   ....*....|....*....|....*.
gi 19922488    411 KRVKLNIDAEYLIPKLPSPRDLQPFP 436
Cdd:smart01035 239 RRNKLNIDPESLLPKLPSPKDLRPFP 264
BOP1NT pfam08145
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 171-436 1.63e-146

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


Pssm-ID: 462371  Cd Length: 259  Bit Score: 429.65  E-value: 1.63e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488   171 YDEYKHIGYDWDAKKIIKPPQGDQIDEFLRKIEDPDFWRTVKDPLTGQDVRLTDEDIALIKRIVSGRIPNKDHEEYEPWI 250
Cdd:pfam08145   1 YDDYPHIGYDIDGKKIMKPAKGDALDKFLDSMDDPNAWRTVYDKLTGKDVVLTDEDLELIRRIQKGEFPDAGYDPYEPYV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488   251 EWFTSEVEKMPIKNVPDHKRSFLPSVSEKKRVSRMVHALKMGWMKTTEEVEREkqakrgPKFYMLWETDTSREH-MRRIH 329
Cdd:pfam08145  81 EWFTSEDEIHPLSNAPEPKRRFIPSKWEAKKVMKLVRAIRMGRIKPRKPKEEE------PKFYDLWADEDETEEeRRRRP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488   330 DPVSAPKRDLPGHAESYNPPPEYLFDAKETKEWLKLkdEPHKRKLHFMPQKFKSLREVPAYSRYLRERFLRCLDLYLCPR 409
Cdd:pfam08145 155 DHIPAPKLPLPGHAESYNPPPEYLPTEEERKKWEEM--DPEDRKLNFLPQKYDSLRLVPAYEKFIKERFERCLDLYLCPR 232

                         250       260
                  ....*....|....*....|....*..
gi 19922488   410 AKRVKLNIDAEYLIPKLPSPRDLQPFP 436
Cdd:pfam08145 233 VRKNRLNIDPESLLPKLPSPKDLRPFP 259
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 442-783 8.11e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.86  E-value: 8.11e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 442 VYRGHTDLVRSVSVEPKGEYLVSGSDDKTVKIWEIATGRCIRTIET-DEVVRCVAWCPNPKLsiIAVATGNRLLLVnpkv 520
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhTGPVRDVAASADGTY--LASGSSDKTIRL---- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 521 gdkvlvkktddllaeapsqdvieseriktavqWSnaeaDEQEKGVRVVITHFKPIRQVTWHGRGDYLATVmpeGANRSAL 600
Cdd:cd00200  78 --------------------------------WD----LETGECVRTLTGHTSYVSSVAFSPDGRILSSS---SRDKTIK 118

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 601 IHQLSKRRSQIPFSKSKGLIQFVLFHPVKPcfFVATQHN---IRIYDLVKQELVKKLLTNSKWISGMSIHPKGDNLLVST 677
Cdd:cd00200 119 VWDVETGKCLTTLRGHTDWVNSVAFSPDGT--FVASSSQdgtIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSS 196

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 678 YDKK-MLWfdlDLST-KPYQTMRLHRNAVRSVAFHLRYPLFASGSDDQAVIvshgmVYNDLLQnpliVPLKKLQTHEKRd 755
Cdd:cd00200 197 SDGTiKLW---DLSTgKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIR-----VWDLRTG----ECVQTLSGHTNS- 263

                       330       340
                ....*....|....*....|....*...
gi 19922488 756 efgVLDVNWHPVQPWVFSTGADSTIRLY 783
Cdd:cd00200 264 ---VTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
442-783 1.45e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.80  E-value: 1.45e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 442 VYRGHTDLVRSVSVEPKGEYLVSGSDDKTVKIWEIATGRCIRTIET-DEVVRCVAWCPNPKLsiiaVATGnrlllvnpkv 520
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGhSGAVTSVAFSPDGKL----LASG---------- 180

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 521 gdkvlvkktddllaeapSQDvieseriKTAVQWSNAEADEqekgVRVVITHFKPIRQVTWHGRGDYLATVmpeGANRSAL 600
Cdd:COG2319 181 -----------------SDD-------GTVRLWDLATGKL----LRTLTGHTGAVRSVAFSPDGKLLASG---SADGTVR 229

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 601 IHQLSKRRSQIPFSKSKGLIQFVLFHPVKPCFFVATQHN-IRIYDLVKQELVKKLLTNSKWISGMSIHPKGDNLLVSTYD 679
Cdd:COG2319 230 LWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGtVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 680 KKMLWFDLDlSTKPYQTMRLHRNAVRSVAFHlryP---LFASGSDDQAVIVShgmvynDLLQNPLivpLKKLQTHEKrde 756
Cdd:COG2319 310 GTVRLWDLA-TGKLLRTLTGHTGAVRSVAFS---PdgkTLASGSDDGTVRLW------DLATGEL---LRTLTGHTG--- 373

                       330       340
                ....*....|....*....|....*..
gi 19922488 757 fGVLDVNWHPVQPWVFSTGADSTIRLY 783
Cdd:COG2319 374 -AVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 442-686 4.62e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.24  E-value: 4.62e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 442 VYRGHTDLVRSVSVEPKGEYLVSGSDDKTVKIWEIATGRCIRTIET-DEVVRCVAWCPNPKLsiiaVATGnrlllvnpkv 520
Cdd:cd00200  88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGTF----VASS---------- 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 521 gdkvlvkktddllaeapSQDvieseriKTAVQWSNaeadEQEKGVRVVITHFKPIRQVTWHGRGDYLATVmpeGANRSAL 600
Cdd:cd00200 154 -----------------SQD-------GTIKLWDL----RTGKCVATLTGHTGEVNSVAFSPDGEKLLSS---SSDGTIK 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 601 IHQLSKRRSQIPFSKSKGLIQFVLFHPVKPCFFVATQ-HNIRIYDLVKQELVKKLLTNSKWISGMSIHPKGDNLLVSTYD 679
Cdd:cd00200 203 LWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEdGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282


                ....*..
gi 19922488 680 KKMLWFD 686
Cdd:cd00200 283 GTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 441-589 6.66e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.08  E-value: 6.66e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 441 MVYRGHTDLVRSVSVEPKGEYLVSGSDDKTVKIWEIATGRCIRTIET-DEVVRCVAWCPNPKlSIIAVATGNRLLLVNPK 519
Cdd:cd00200 129 TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGhTGEVNSVAFSPDGE-KLLSSSSDGTIKLWDLS 207

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19922488 520 VGD--KVLVKKTDDLLAEAPSQD---VIESERIKTAVQWSnaeaDEQEKGVRVVITHFKPIRQVTWHGRGDYLAT 589
Cdd:cd00200 208 TGKclGTLRGHENGVNSVAFSPDgylLASGSEDGTIRVWD----LRTGECVQTLSGHTNSVTSLAWSPDGKRLAS 278
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 441-475 2.12e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 2.12e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 19922488    441 MVYRGHTDLVRSVSVEPKGEYLVSGSDDKTVKIWE 475
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
441-475 4.22e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.65  E-value: 4.22e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 19922488   441 MVYRGHTDLVRSVSVEPKGEYLVSGSDDKTVKIWE 475
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
442-478 2.03e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 2.03e-07
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 19922488 442 VYRGHTDLVRSVSVEPKGEYLVSGSDDKTVKIWEIAT 478
Cdd:COG2319 367 TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 693-783 2.32e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.03  E-value: 2.32e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922488 693 PYQTMRLHRNAVRSVAFHLRYPLFASGSDDQAVIvshgmVYNdlLQNPliVPLKKLQTHEKrdefGVLDVNWHPVQPWVF 772
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIK-----VWD--LETG--ELLRTLKGHTG----PVRDVAASADGTYLA 67

                        90
                ....*....|.
gi 19922488 773 STGADSTIRLY 783
Cdd:cd00200  68 SGSSDKTIRLW 78
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 438-475 4.19e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.26  E-value: 4.19e-06
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 19922488 438 VESMVYRGHTDLVRSVSVEPKGEYLVSGSDDKTVKIWE 475
Cdd:cd00200 252 ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 444-488 1.42e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 44.68  E-value: 1.42e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 19922488   444 RGHTDLVRSVSVEPKGEYLVSGSDDKTVKIWEIATGRC----IRTIETD 488
Cdd:pfam20426 121 RQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSsekrSRNTQTE 169
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 690-727 1.16e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.16e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 19922488    690 STKPYQTMRLHRNAVRSVAFHLRYPLFASGSDDQAVIV 727
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
744-783 6.24e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 6.24e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 19922488   744 PLKKLQTHEKrdefGVLDVNWHPVQPWVFSTGADSTIRLY 783
Cdd:pfam00400   3 LLKTLEGHTG----SVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
692-727 6.30e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 6.30e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 19922488   692 KPYQTMRLHRNAVRSVAFHLRYPLFASGSDDQAVIV 727
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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