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Conserved domains on  [gi|20130067|ref|NP_611191|]
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uncharacterized protein Dmel_CG15605 [Drosophila melanogaster]

Protein Classification

RWD domain-containing protein( domain architecture ID 10651873)

RWD domain-containing protein such as RWD domain-containing protein 3 (RWDD3), also known as RSUME, a RWD-containing protein that enhances SUMO conjugation by interacting with the SUMO conjugase Ubc9, increases Ubc9 thioester formation and therefore favours sumoylation of specific targets

CATH:  3.10.110.10
Gene Ontology:  GO:0005515
PubMed:  26276859|25918163

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RWD smart00591
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily ...
 33-145 3.35e-21

domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain;


:

Pssm-ID: 214735  Cd Length: 107  Bit Score: 82.41  E-value: 3.35e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130067     33 ENEVRTMHYLGLAYVVLSRRPNLQLKVPLSTQNYEdgaivgaGERGGYALQLLFTCAANYPLARPLVEIVEKRNVSDAFE 112
Cdd:smart00591   1 ELEALESIYPEDFEVIDEDARIPEITIKLSPSSDE-------GEDQYVSLTLQVKLPENYPDEAPPISLLNSEGLSDEQL 73

                           90       100       110
                   ....*....|....*....|....*....|...
gi 20130067    113 QVLRKEIDLILEEHLGLQMIVPVVTRLQITLNT 145
Cdd:smart00591  74 AELLKKLEEIAEENLGEVMIFELVEKLQEFLSE 106
 
Name Accession Description Interval E-value
RWD smart00591
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily ...
 33-145 3.35e-21

domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain;


Pssm-ID: 214735  Cd Length: 107  Bit Score: 82.41  E-value: 3.35e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130067     33 ENEVRTMHYLGLAYVVLSRRPNLQLKVPLSTQNYEdgaivgaGERGGYALQLLFTCAANYPLARPLVEIVEKRNVSDAFE 112
Cdd:smart00591   1 ELEALESIYPEDFEVIDEDARIPEITIKLSPSSDE-------GEDQYVSLTLQVKLPENYPDEAPPISLLNSEGLSDEQL 73

                           90       100       110
                   ....*....|....*....|....*....|...
gi 20130067    113 QVLRKEIDLILEEHLGLQMIVPVVTRLQITLNT 145
Cdd:smart00591  74 AELLKKLEEIAEENLGEVMIFELVEKLQEFLSE 106
RWD pfam05773
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ...
 30-140 6.05e-16

RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.


Pssm-ID: 399058  Cd Length: 111  Bit Score: 68.89  E-value: 6.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130067    30 DLQENEVRTMHYL-GLAYVVLSRRP--NLQLKVPLSTQNYEDGaivgagERGGYALQLLFTCAANYPLARPLVEIVEKRN 106
Cdd:pfam05773   1 EEQEEELEALESIyPDEFEVISDSPyeSLEIEIKLSLDSDESD------SSHLPPLVLKFTLPEDYPDEPPKISLSSPWN 74

                          90       100       110
                  ....*....|....*....|....*....|....
gi 20130067   107 VSDAFEQVLRKEIDLILEEHLGLQMIVPVVTRLQ 140
Cdd:pfam05773  75 LSDEQVLSLLEELEELAEENLGEVMIFELIEWLQ 108
RWD_RWDD1 cd23816
RWD domain of RWD domain-containing protein 1 (RWDD1) and related proteins; RWDD1, also called ...
 48-146 2.02e-12

RWD domain of RWD domain-containing protein 1 (RWDD1) and related proteins; RWDD1, also called DRG family-regulatory protein 2 (DFRP2), or PTD013, interacts with DRG2 and protects DRG2 from proteolytic degradation. It is an androgen receptor-interacting protein that functions as a coactivator of androgen-dependent transcription.


Pssm-ID: 467652  Cd Length: 118  Bit Score: 60.00  E-value: 2.02e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130067  48 VLSRRPNLQLKVPLSTQNYEDgaivgagERGGYALQLLFTCAANYPLARPLVEIVEKRNVSDAFEQVLRKEIDLILEEHL 127
Cdd:cd23816  22 VLSEEPPISFTITVTSEEEEN-------EDETVSVTLKFTYTEKYPDEAPLIEIISHENLEDEDIEDLLELLEQQAEENL 94

                        90
                ....*....|....*....
gi 20130067 128 GLQMIVPVVTRLQITLNTE 146
Cdd:cd23816  95 GMVMVFTIVSAVQEKLNEI 113
 
Name Accession Description Interval E-value
RWD smart00591
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily ...
 33-145 3.35e-21

domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain;


Pssm-ID: 214735  Cd Length: 107  Bit Score: 82.41  E-value: 3.35e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130067     33 ENEVRTMHYLGLAYVVLSRRPNLQLKVPLSTQNYEdgaivgaGERGGYALQLLFTCAANYPLARPLVEIVEKRNVSDAFE 112
Cdd:smart00591   1 ELEALESIYPEDFEVIDEDARIPEITIKLSPSSDE-------GEDQYVSLTLQVKLPENYPDEAPPISLLNSEGLSDEQL 73

                           90       100       110
                   ....*....|....*....|....*....|...
gi 20130067    113 QVLRKEIDLILEEHLGLQMIVPVVTRLQITLNT 145
Cdd:smart00591  74 AELLKKLEEIAEENLGEVMIFELVEKLQEFLSE 106
RWD pfam05773
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ...
 30-140 6.05e-16

RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.


Pssm-ID: 399058  Cd Length: 111  Bit Score: 68.89  E-value: 6.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130067    30 DLQENEVRTMHYL-GLAYVVLSRRP--NLQLKVPLSTQNYEDGaivgagERGGYALQLLFTCAANYPLARPLVEIVEKRN 106
Cdd:pfam05773   1 EEQEEELEALESIyPDEFEVISDSPyeSLEIEIKLSLDSDESD------SSHLPPLVLKFTLPEDYPDEPPKISLSSPWN 74

                          90       100       110
                  ....*....|....*....|....*....|....
gi 20130067   107 VSDAFEQVLRKEIDLILEEHLGLQMIVPVVTRLQ 140
Cdd:pfam05773  75 LSDEQVLSLLEELEELAEENLGEVMIFELIEWLQ 108
RWD_RWDD1 cd23816
RWD domain of RWD domain-containing protein 1 (RWDD1) and related proteins; RWDD1, also called ...
 48-146 2.02e-12

RWD domain of RWD domain-containing protein 1 (RWDD1) and related proteins; RWDD1, also called DRG family-regulatory protein 2 (DFRP2), or PTD013, interacts with DRG2 and protects DRG2 from proteolytic degradation. It is an androgen receptor-interacting protein that functions as a coactivator of androgen-dependent transcription.


Pssm-ID: 467652  Cd Length: 118  Bit Score: 60.00  E-value: 2.02e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130067  48 VLSRRPNLQLKVPLSTQNYEDgaivgagERGGYALQLLFTCAANYPLARPLVEIVEKRNVSDAFEQVLRKEIDLILEEHL 127
Cdd:cd23816  22 VLSEEPPISFTITVTSEEEEN-------EDETVSVTLKFTYTEKYPDEAPLIEIISHENLEDEDIEDLLELLEQQAEENL 94

                        90
                ....*....|....*....
gi 20130067 128 GLQMIVPVVTRLQITLNTE 146
Cdd:cd23816  95 GMVMVFTIVSAVQEKLNEI 113
RWD_GCN2 cd23823
RWD domain of eIF-2-alpha kinase GCN2 and related proteins; GCN2 (EC 2.7.11.1), also called ...
 82-140 3.76e-05

RWD domain of eIF-2-alpha kinase GCN2 and related proteins; GCN2 (EC 2.7.11.1), also called eukaryotic translation initiation factor 2-alpha kinase 4 (EIF2AK4), acts as a metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability. It also plays a role in modulating the adaptive immune response to yellow fever virus infection and promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation.


Pssm-ID: 467659  Cd Length: 117  Bit Score: 40.67  E-value: 3.76e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 20130067  82 LQLLFTCAANYPLARPLVEIVEKRNVSDAFEQVLRKEIDLILEEHLGLQMIVPVVTRLQ 140
Cdd:cd23823  52 VDLHVKFPPTYPDVPPEIELENVKGLSDEQLEELLKELEELAKELLGEEMIFELAEAVQ 110
RWD_DRWD_ELF-like cd11605
RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF ...
 71-139 4.48e-04

RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF domains. They belong to the ubiquitin-conjugating (UBC) superfamily that represents a structural domain with an alpha-beta(4)-alpha(3) core fold. The RWD domain (named after three major RWD-containing proteins: RING finger, WD-repeat-containing proteins and DEXD-like helicases) mediates protein-protein interactions in a variety of pathways in eukaryotes. The DRWD domain is responsible for substrate binding. It is involved in interactions with other kinetochore proteins. The ELF (N-terminal E2-like fold) domain is found in all Fanconi anemia group L protein (FANCL) homologs. It is required to promote efficient DNA damage-induced FANCD2 (Fanconi anemia group D2 protein) monoubiquitination in vertebrate cells.


Pssm-ID: 467641  Cd Length: 94  Bit Score: 37.55  E-value: 4.48e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20130067  71 IVGAGERGGYALQLLFTCAANY-PLARPLVEIVEKRNVSDAFEQVLRKEIDLILEEHLGLQMIVPVVTRL 139
Cdd:cd11605  25 LSPEEEEDDPPLELEFTLPPGYpPEEPPLITLRSPKLSSAERLSLLKLELEEAAEENLGEPMLFDLVEAL 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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