BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653708    215 CVLYVESKDNPAMDVVRNLMLTRIRKFLLTFVATRDFLDLPTSHLIFLLESDQICVNTEIEVFFIAVRWLGHDWNKRKVH 294
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90
                   ....*....|....*....
gi 24653708    295 VRRLMSCIRFNLMPLWYLL 313
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLL 99

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653708    215 CVLYVESKDNPAMDVVRNLMLTRIRKFLLTFVATRDFLDLPTSHLIFLLESDQICVNTEIEVFFIAVRWLGHDWNKRKVH 294
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90
                   ....*....|....*....
gi 24653708    295 VRRLMSCIRFNLMPLWYLL 313
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLL 99

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24653708 251 FLDLPTSHLIFLLESDQICVNTEIEVFFIAVRWLGHDWNKRKVHVRRLMSCIRFNLMPLWYLLyaRREEDHPLV 324
Cdd:cd18445  42 FLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPENRKEHLAELLEHVRLPLLSPEYLV--QRVEEEELI 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653708 116 VQIEINNMYFNCHFIVLQVYSRFFSEL------EMIPLLVTLPEkiVSQKAFMLSYKWMLSDEPVLELAHIVEVYVAATY 189
Cdd:cd18186   4 VTLVVGGREFPAHRAVLAARSPYFRAMfssgmkESSSSEIELDD--VSPEAFEALLDYIYTGELELSEENVEELLAAADK 81

                .
gi 24653708 190 L 190
Cdd:cd18186  82 L 82

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653708    215 CVLYVESKDNPAMDVVRNLMLTRIRKFLLTFVATRDFLDLPTSHLIFLLESDQICVNTEIEVFFIAVRWLGHDWNKRKVH 294
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90
                   ....*....|....*....
gi 24653708    295 VRRLMSCIRFNLMPLWYLL 313
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLL 99

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24653708 251 FLDLPTSHLIFLLESDQICVNTEIEVFFIAVRWLGHDWNKRKVHVRRLMSCIRFNLMPLWYLLyaRREEDHPLV 324
Cdd:cd18445  42 FLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPENRKEHLAELLEHVRLPLLSPEYLV--QRVEEEELI 113

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24653708 240 KFLLTFVATRDFLDLPTSHLIFLLESDQICVNTEIEVFFIAVRWLGHDWNKRKVhVRRLMSCIRFNLM 307
Cdd:cd18465  31 RHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPSRRAS-ASHVLCHIRFPLM 97

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24653708 246 VATRDFLDLPTSHLIFLLESDQICVNTEIEVFFIAVRWLGHDWNKRKVHVRRLMSCIRFNLMPLWYLLyaRREEDHPLV 324
Cdd:cd18512  37 VLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKEVRQEHMAHLMEHVRLPLLSREYLV--QRVEEETLV 113

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24653708 250 DFLDLPTSHLIFLLESDQICVNTEIEVFFIAVRWLGHDWNKRKVHVRRLMSCIRFNLMP 308
Cdd:cd18444  42 EFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLPERKKHLAKLLALIRLPLLT 100

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24653708 242 LLTFVATRDFLDLPTSHLIFLLESDQICVNTEIEVFFIAVRWLGHDWNKRKVHVRRLMSCIRFNLMP 308
Cdd:cd18510  34 FLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDLQNRQKDLGMLLSYIRLPLLP 100

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653708 250 DFLDLPTSHLIFLLESDQICVNTEIEVFFIAVRWLGHDWNKRKVHVRRLMSCIRFNLMPLWYLLYARREE 319
Cdd:cd18513  41 EFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKEARLEHMAKLMEHVRLPLLPRDYLVQTVEEE 110

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24653708 244 TFVATRDFLDLPTSHLIFLLESDQICVNTEIEVFFIAVRWLGHDWNKRKVHVRRLMSCIRFNLMP 308
Cdd:cd18515  34 TICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKRHCYLSELLQTVRLALLP 98

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24653708 238 IRKFLLTFVATRDFLDLPTSHLIFLLESDQICVNTEIEVFFIAVRWLGHDWNKRKVHVRRLMS-CIRF 304
Cdd:cd18483  29 IRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQSKREMHLPEIFAkCIRM 96

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 24653708 252 LDLPTSHLIFLLESDQICVNTEIEVFFIAVRWLGHDWNKRKVHVRRLMSCIRF 304
Cdd:cd18468  42 LSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKNRKQHIAELLAVVRL 94

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24653708 242 LLTFVATRDFLDLPTSHLIFLLESDQICVNTEIEVFFIAVRWLGHDWNKRKVHVRRLMSCIRFNLMP 308
Cdd:cd18509  34 IMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCSDLSMLLAYIRLPLLP 100

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24653708 248 TRDFLDLPTSHLIFLLESDQICVNTEIEVFFIAVRWLGHDWNKRKVHVRRLMSCIRFNLMP 308
Cdd:cd18514  39 SEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLEKRKDYLPELLRNVRLALLP 99

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24653708 250 DFLDLPTSHLIFLLESDQICVNTEIEVFFIAVRWLGHDWNKRKVHVRRLMSCIRFNLMP 308
Cdd:cd18517  41 DFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKENRVKSLGEIFDCIRFRLMP 99

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24653708 246 VATRDFLDLPTSHLIFLLESDQICVNTEIEVFFIAVRWLGHDWNKRKVHVRRLMSCIRFNLMPLWYL 312
Cdd:cd18452  37 VQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKEEREDYLPELLQYVRLPLLSPRYI 103

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 24653708 244 TFVATRDFLDLPTSHLIFLLESDQICVNTEIEVFFIAVRWL 284
Cdd:cd18472  35 EVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653708 248 TRDFLDLPTSHLIFLLESDQICVNTEIEVFFIAVRWLGHDWNKRKVHVRRLMSCIRFNLM 307
Cdd:cd18467  39 TEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQERQKYLAQLLHCVRLPLL 98

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 24653708 238 IRKFLLTFVATRDFLDLPTSHLIFLLESDQICVNTEIEVFFIAVRWLGHD 287
Cdd:cd18508  28 IYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653708 116 VQIEINNMYFNCHFIVLQVYSRFFSEL------EMIPLLVTLPEkiVSQKAFMLSYKWMLSDEPVLELAHIVEVYVAATY 189
Cdd:cd18186   4 VTLVVGGREFPAHRAVLAARSPYFRAMfssgmkESSSSEIELDD--VSPEAFEALLDYIYTGELELSEENVEELLAAADK 81

                .
gi 24653708 190 L 190
Cdd:cd18186  82 L 82

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for Cullin3 E3 ubiquitin-protein ligase complex that target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24653708 237 RIRKFLL-TFV---ATRDFLD-LPTSHLIFLLESDQICVNTEIEVFFIAVRWLGHDwNKRKVHVRRLMSCIRFNLM 307
Cdd:cd18454  26 KLDSFLLeNFVplmSRPDFLSyLSFEKLMSYLDNDHLSRFPEIELYEAVQAWLRHD-RRRWRHTDTIIQNIRFCLM 100