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Conserved domains on  [gi|24653694|ref|NP_610983|]
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jet fuel, isoform A [Drosophila melanogaster]

Protein Classification

MFS transporter( domain architecture ID 13023754)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  26098515|26758938|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 128-683 7.60e-133

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 398.50  E-value: 7.60e-133
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 128 GSLFPLMGVYFKQMGMNPGQCGILVGMRPFVEFLSAPFWGSYADRCRQGKRLLLGSLACWVLFTIPLSFirpeaincier 207
Cdd:cd17335  14 GSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFF----------- 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 208 rnatdfvltytrtkrdlsamyeqehldmgtgtmpadealeeaeaahsrhkrslllpridagispVHINFVsnyddkyhrd 287
Cdd:cd17335  83 ----------------------------------------------------------------VAQIFW---------- 88

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 288 yvtPIFSSMVyrtpdiqkaffllllvilIGEFFSAPAITLADSAVITLLGEDADKYGHQRMFGSLGWGISMFLVGIALDH 367
Cdd:cd17335  89 ---LLLLLVI------------------LGAFFSAPVVPLVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDR 147

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 368 STSfsnhpcgagnkEKNYNICFSIFSVLMTCAIISASKITFKYDPideqlaaqqqaqfvdpnkraeeesmnqlaaqlnlp 447
Cdd:cd17335 148 SST-----------YKNYTIAFYVFAVLMLLALLLALKFPFRPKH----------------------------------- 181

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 448 slavgsgsaasgacaggvssflatghqpqphigaeskvfaqtAKELPEWMTVLTHFKDLKTASFLFVAWFMGFGIGLIFT 527
Cdd:cd17335 182 ------------------------------------------PEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYS 219

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 528 FLFWHLQDYGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLRFLYISYLTNPWMVLPFELMQGIT 607
Cdd:cd17335 220 FLFWHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLT 299

                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24653694 608 HAAVWAASCSYIAHNTPKHLRASAQGVLQGIHHGLGRGCGAIIGGMFVTYYGTTTTFRWYGIACLFVLGFFIFVNF 683
Cdd:cd17335 300 FALVWAAAVSYASAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
 
Name Accession Description Interval E-value
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 128-683 7.60e-133

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 398.50  E-value: 7.60e-133
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 128 GSLFPLMGVYFKQMGMNPGQCGILVGMRPFVEFLSAPFWGSYADRCRQGKRLLLGSLACWVLFTIPLSFirpeaincier 207
Cdd:cd17335  14 GSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFF----------- 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 208 rnatdfvltytrtkrdlsamyeqehldmgtgtmpadealeeaeaahsrhkrslllpridagispVHINFVsnyddkyhrd 287
Cdd:cd17335  83 ----------------------------------------------------------------VAQIFW---------- 88

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 288 yvtPIFSSMVyrtpdiqkaffllllvilIGEFFSAPAITLADSAVITLLGEDADKYGHQRMFGSLGWGISMFLVGIALDH 367
Cdd:cd17335  89 ---LLLLLVI------------------LGAFFSAPVVPLVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDR 147

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 368 STSfsnhpcgagnkEKNYNICFSIFSVLMTCAIISASKITFKYDPideqlaaqqqaqfvdpnkraeeesmnqlaaqlnlp 447
Cdd:cd17335 148 SST-----------YKNYTIAFYVFAVLMLLALLLALKFPFRPKH----------------------------------- 181

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 448 slavgsgsaasgacaggvssflatghqpqphigaeskvfaqtAKELPEWMTVLTHFKDLKTASFLFVAWFMGFGIGLIFT 527
Cdd:cd17335 182 ------------------------------------------PEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYS 219

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 528 FLFWHLQDYGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLRFLYISYLTNPWMVLPFELMQGIT 607
Cdd:cd17335 220 FLFWHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLT 299

                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24653694 608 HAAVWAASCSYIAHNTPKHLRASAQGVLQGIHHGLGRGCGAIIGGMFVTYYGTTTTFRWYGIACLFVLGFFIFVNF 683
Cdd:cd17335 300 FALVWAAAVSYASAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
 128-665 8.17e-52

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 184.37  E-value: 8.17e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694   128 GSLFPLMGVYFKQMGMNPGQCGILVGMRPFVEFLSAPFWGSYADRCRQGKRLLLGSLACWVLFTIPLSFIrpeaincier 207
Cdd:pfam12832  16 GCLLPYWGLYLRSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAAVLFLSVLFI---------- 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694   208 rnatdfvltytrtkrdlsamyeqehldmgtgtmpadealeeaeaahsrhkrslllpridagisPVHINFVSnyddkyhrd 287
Cdd:pfam12832  86 ---------------------------------------------------------------PISLTFWW--------- 93

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694   288 yvtpIFSSMVyrtpdiqkaffllllvilIGEFFSAPAITLADSAVITLLGEDADKYGHQRMFGSLGWGISMFLVGIALDH 367
Cdd:pfam12832  94 ----LALLVV------------------LFSFFWNAILPQFEVATLQHLGEKRKDYGRQRLWGSVGFALSVFGLGALFDH 151

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694   368 sTSFSNHPCGAgnkeknynicFSIFSVLMTCAIIsaskitfkydpideqlaaqqqaqfvdpnkraeeesmnqLAAQLNLP 447
Cdd:pfam12832 152 -YSVGLLPSVL----------FYLFAALMLLSLL--------------------------------------LPLAPPEM 182

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694   448 SLAVGSGSaasgacaggVSSFLATghqpqphigaeskvfaqtakelpewmtvlthFKDLKTASFLFVAWFMGFGIGLIFT 527
Cdd:pfam12832 183 EYESKGGS---------KAVFWNL-------------------------------LKQPEVIIFFLAAFLLGFSHGPFYT 222

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694   528 FLFWHLQDYGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLRFLYISYL-TNPWMVLPFELMQGI 606
Cdd:pfam12832 223 FLFLYLENLGASNTLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLYAFFvENPWLVLPIQFLHAI 302

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 24653694   607 THAAVWAASCSYIAHNTPKHLRASAQGVLQGIHHGLGRGCGAIIGGMFVTYYGTTTTFR 665
Cdd:pfam12832 303 SFGLTHAAAIEYVRRIFPGSLQGTGQALYSGLYFGLGGALGSLIGGQLWDLFGARFTFR 361
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
497-681 8.24e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 79.63  E-value: 8.24e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 497 MTVLTHFKDLKTASFLFVAWFMGFGIGLIFTFLFWHLQDYGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCL 576
Cdd:COG2814   1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 577 GLIGNVLRFLYISYLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLQGIhHGLGRGCGAIIGGMFVT 656
Cdd:COG2814  81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAG-LGLGPALGPLLGGLLAD 159

                       170       180
                ....*....|....*....|....*
gi 24653694 657 YYGTTTTFRWYGIACLFVLGFFIFV 681
Cdd:COG2814 160 LFGWRWVFLVNAVLALLALLLLLRL 184
 
Name Accession Description Interval E-value
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 128-683 7.60e-133

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 398.50  E-value: 7.60e-133
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 128 GSLFPLMGVYFKQMGMNPGQCGILVGMRPFVEFLSAPFWGSYADRCRQGKRLLLGSLACWVLFTIPLSFirpeaincier 207
Cdd:cd17335  14 GSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFF----------- 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 208 rnatdfvltytrtkrdlsamyeqehldmgtgtmpadealeeaeaahsrhkrslllpridagispVHINFVsnyddkyhrd 287
Cdd:cd17335  83 ----------------------------------------------------------------VAQIFW---------- 88

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 288 yvtPIFSSMVyrtpdiqkaffllllvilIGEFFSAPAITLADSAVITLLGEDADKYGHQRMFGSLGWGISMFLVGIALDH 367
Cdd:cd17335  89 ---LLLLLVI------------------LGAFFSAPVVPLVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDR 147

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 368 STSfsnhpcgagnkEKNYNICFSIFSVLMTCAIISASKITFKYDPideqlaaqqqaqfvdpnkraeeesmnqlaaqlnlp 447
Cdd:cd17335 148 SST-----------YKNYTIAFYVFAVLMLLALLLALKFPFRPKH----------------------------------- 181

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 448 slavgsgsaasgacaggvssflatghqpqphigaeskvfaqtAKELPEWMTVLTHFKDLKTASFLFVAWFMGFGIGLIFT 527
Cdd:cd17335 182 ------------------------------------------PEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYS 219

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 528 FLFWHLQDYGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLRFLYISYLTNPWMVLPFELMQGIT 607
Cdd:cd17335 220 FLFWHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLT 299

                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24653694 608 HAAVWAASCSYIAHNTPKHLRASAQGVLQGIHHGLGRGCGAIIGGMFVTYYGTTTTFRWYGIACLFVLGFFIFVNF 683
Cdd:cd17335 300 FALVWAAAVSYASAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
 128-665 8.17e-52

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 184.37  E-value: 8.17e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694   128 GSLFPLMGVYFKQMGMNPGQCGILVGMRPFVEFLSAPFWGSYADRCRQGKRLLLGSLACWVLFTIPLSFIrpeaincier 207
Cdd:pfam12832  16 GCLLPYWGLYLRSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAAVLFLSVLFI---------- 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694   208 rnatdfvltytrtkrdlsamyeqehldmgtgtmpadealeeaeaahsrhkrslllpridagisPVHINFVSnyddkyhrd 287
Cdd:pfam12832  86 ---------------------------------------------------------------PISLTFWW--------- 93

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694   288 yvtpIFSSMVyrtpdiqkaffllllvilIGEFFSAPAITLADSAVITLLGEDADKYGHQRMFGSLGWGISMFLVGIALDH 367
Cdd:pfam12832  94 ----LALLVV------------------LFSFFWNAILPQFEVATLQHLGEKRKDYGRQRLWGSVGFALSVFGLGALFDH 151

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694   368 sTSFSNHPCGAgnkeknynicFSIFSVLMTCAIIsaskitfkydpideqlaaqqqaqfvdpnkraeeesmnqLAAQLNLP 447
Cdd:pfam12832 152 -YSVGLLPSVL----------FYLFAALMLLSLL--------------------------------------LPLAPPEM 182

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694   448 SLAVGSGSaasgacaggVSSFLATghqpqphigaeskvfaqtakelpewmtvlthFKDLKTASFLFVAWFMGFGIGLIFT 527
Cdd:pfam12832 183 EYESKGGS---------KAVFWNL-------------------------------LKQPEVIIFFLAAFLLGFSHGPFYT 222

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694   528 FLFWHLQDYGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLRFLYISYL-TNPWMVLPFELMQGI 606
Cdd:pfam12832 223 FLFLYLENLGASNTLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLYAFFvENPWLVLPIQFLHAI 302

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 24653694   607 THAAVWAASCSYIAHNTPKHLRASAQGVLQGIHHGLGRGCGAIIGGMFVTYYGTTTTFR 665
Cdd:pfam12832 303 SFGLTHAAAIEYVRRIFPGSLQGTGQALYSGLYFGLGGALGSLIGGQLWDLFGARFTFR 361
MFS_MFSD6L cd17479
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ...
 317-679 1.79e-26

Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341032 [Multi-domain]  Cd Length: 376  Bit Score: 112.02  E-value: 1.79e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 317 GEFFSAPAITLADSAVITLLG--EDADKYGHQRMFGSLGWGISMFLVGIALDHStsfsnhPCGAGNKEKNYNICFSIFSV 394
Cdd:cd17479  93 WELLSAPLEKVADDSLYEYLDfvDATERYGKLKVWSALGAAFGPCGITLLVDNL------DCFLPPKISRILLHFYTYGG 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 395 LMTCAIIsaskITFKYdPIdeqlaaqqqaqfvdPNKRAEEESmnqlaaqlnlpslavGSGSAASGACAGGVSSFLATghq 474
Cdd:cd17479 167 FMILTFL----LSFFY-PI--------------PVPKKEEHS---------------SKVVKGLRLLGGDGRAILYA--- 209

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 475 pqphigaeskvfaqtakelpewMTVLthfkdlktasflfvawFMGFGIGLIFTFLFWHLQDYGGTPTLFGVASVINHVSE 554
Cdd:cd17479 210 ----------------------LTVF----------------LVGFVGSTVQNFLFWLMQDKGGSELHMGLSIALALLSE 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 555 IFAYFFSFRLITQIGHVKVLCLGLIGNVLRFLYISYLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGV 634
Cdd:cd17479 252 ILMSFFGNWLLRKLGHAGCVVLGLLGLGAQLLYYSFLWTPWAVLPIELLHAFSNGALWWAVNSQVEFLASPGMERSLQLV 331

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 24653694 635 LQGIHHGLGRGCGAIIGGMFVTYYGTTTTFRWYGIACLFVLGFFI 679
Cdd:cd17479 332 LRALYYGIGFALGSFVSGFIYDRFGLAILYQACCVVLGLWLIIFA 376
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 487-680 1.11e-16

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 82.62  E-value: 1.11e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 487 AQTAKELPEWMTVLTHFKDLKTASFLFVawFMGFGIGLIFTFLFWHLQDYGGTPT-----LFGVASVINhvseIFAYFFS 561
Cdd:cd17325 182 AVSAARLRSGLRLLLRDRRLLALFLAIF--VLAFAFGALEPFLPLYAAELGGLSPaqiglLFGAQGLAS----ALSQPPA 255

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 562 FRLITQIGHVKVLCLGLIGNVLRFLYISYLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLQGIhHG 641
Cdd:cd17325 256 GKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTA-FS 334

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 24653694 642 LGRGCGAIIGGMFVTYYGTTTTFRWYGIACLFVLGFFIF 680
Cdd:cd17325 335 LGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
MFS_1 pfam07690
Major Facilitator Superfamily;
511-681 1.13e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 82.08  E-value: 1.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694   511 FLFVAWFMGFGIGLIFTFLFWHL-QDYGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLRFLYIS 589
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694   590 YLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLQGIhHGLGRGCGAIIGGMFVTYYGTTTTFRWYGI 669
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAG-FGLGAALGPLLGGLLASLFGWRAAFLILAI 159

                         170
                  ....*....|..
gi 24653694   670 ACLFVLGFFIFV 681
Cdd:pfam07690 160 LSLLAAVLLLLP 171
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
497-681 8.24e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 79.63  E-value: 8.24e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 497 MTVLTHFKDLKTASFLFVAWFMGFGIGLIFTFLFWHLQDYGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCL 576
Cdd:COG2814   1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 577 GLIGNVLRFLYISYLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLQGIhHGLGRGCGAIIGGMFVT 656
Cdd:COG2814  81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAG-LGLGPALGPLLGGLLAD 159

                       170       180
                ....*....|....*....|....*
gi 24653694 657 YYGTTTTFRWYGIACLFVLGFFIFV 681
Cdd:COG2814 160 LFGWRWVFLVNAVLALLALLLLLRL 184
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 460-681 3.55e-15

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 77.85  E-value: 3.55e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 460 ACAGGVSSFLATGHQPQPHIGAESKVFAQTAKELPEwmTVLTHFKDLKTASFLFVAWFMGFGIGLIFTFLFWHLQDYGG- 538
Cdd:cd06174 159 AALALLAAILLLLVVPDPPESARAKNEEASSKSVLK--LLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGl 236

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 539 TPTLFGVASVINHVSEIFAYFFSFRLIT-QIGHVKVLCLGLIGNVLRFLYISYLTNPWMVLPFELMQGITHAAVWAASCS 617
Cdd:cd06174 237 SVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFA 316

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24653694 618 YIAHNTPKHLRASAQGVLQGIHHGLGRGCGAIIGGMFVTYYGTTTTFrwYGIACLFVLGFFIFV 681
Cdd:cd06174 317 LIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAF--LVLAVLLLLAAILLL 378
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 511-681 7.47e-15

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 76.85  E-value: 7.47e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 511 FLFVAWFMGFGIGLIFTFLFWHLQDYGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLRFLYISY 590
Cdd:cd17325   1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 591 LTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLQGIhHGLGRGCGAIIGGMFVTYYGTTTTFRWYGIA 670
Cdd:cd17325  81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSA-IGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159

                       170
                ....*....|.
gi 24653694 671 CLFVLGFFIFV 681
Cdd:cd17325 160 ALLALVLALLL 170
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 511-710 3.50e-13

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 72.07  E-value: 3.50e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 511 FLFVAWFMGFGIGLIFTFLFWHLQDYGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLRFLYISY 590
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 591 LTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLQGIhHGLGRGCGAIIGGMFVTYYGTTTTFRWYGIA 670
Cdd:cd06174  81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAF-GSVGGILGPLLGGILASSLGFGWRAVFLIAA 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 24653694 671 CLFVLGFFIFVNFYRKEQGFISEIPVTEDPHQVAEETSHL 710
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRV 199
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
511-683 1.50e-12

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 69.90  E-value: 1.50e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 511 FLFVAWFMGFGIGLIFTFLFWHLQ-DYGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLRFLYIS 589
Cdd:COG2271  14 LLFLAYFLNYLDRSNLSVAAPPLQaDLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFG 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 590 YLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLQGIhHGLGRGCGAIIGGMFVTYYGTTTTFRWYGI 669
Cdd:COG2271  94 FATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAG-GPLGGALAPPLLGWLLAAFGWRAAFLILGL 172

                       170
                ....*....|....
gi 24653694 670 ACLFVLGFFIFVNF 683
Cdd:COG2271 173 PGLLLALLRFWLLA 186
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
494-644 4.56e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 68.08  E-value: 4.56e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 494 PEWMTVLTHFKDLKTASFLFVAWFMGFGIGLIFTFLFWHLQD-YGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVK 572
Cdd:COG2814 195 RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR 274

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24653694 573 VLCLGLIGNVLRFLYISYLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLQGIHHGLGR 644
Cdd:COG2814 275 LLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
Nuc_H_symport pfam03825
Nucleoside H+ symporter;
462-677 9.50e-12

Nucleoside H+ symporter;


Pssm-ID: 461066 [Multi-domain]  Cd Length: 399  Bit Score: 67.49  E-value: 9.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694   462 AGGVSSFLATGHQPQPHIGAESKvfAQTAKELPEWMTVLTHFKDLKTASFLFVAwfMGFGIGLIFTFLFWH--LQDYGGT 539
Cdd:pfam03825 165 AAGLSALLVLFALTLPHTPAKQK--ANQSWTTLLGLDAFALLKNKRMAVFFIFS--FLLGAELQIYNVFANtfLTSFDKF 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694   540 P-TLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLRFLYISYLTNP-----WMVLPFELMQGITHAAVWA 613
Cdd:pfam03825 241 IvKHASIIMSLGQISEILFMLTLPFFLKRFGIKNVMLIGIVAWALRFAFFAYGADPtpfgtALLLLSMIVHGVAYDFFNI 320

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24653694   614 ASCSYIAHNTPKHLRASAQGVLQGIHHGLGRGCGAIIGGMFVTYYGTTTTFRWYGI-----------ACLFVLGF 677
Cdd:pfam03825 321 TGYIFVDKEVPPAIRASAQGLFLLMTNGFGCILGSILSGMVVEMFTQDGITDWQTVwlvfagmalvlAVLFMAFF 395
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 511-680 5.33e-10

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 61.85  E-value: 5.33e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 511 FLFVAWFM-GFGIGLIFTFLFWHLQ-DYGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLrFLYI 588
Cdd:cd17316 181 LLILLWFFiSFGYYGLTTFLPTYLQtVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI-LALP 259

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 589 SYL---TNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLQGIHHGLGrGCGAIIGGMFVTYYGTTTTFR 665
Cdd:cd17316 260 LFYllsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGG-GGAPPLIALLLASTGGTGVPA 338

                       170
                ....*....|....*
gi 24653694 666 WYGIACLFVLGFFIF 680
Cdd:cd17316 339 LILALLAIVALIVAL 353
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 460-684 1.55e-09

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 60.31  E-value: 1.55e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 460 ACAGGVSSFLATGHQPQPHIGAESKvfaqtakeLPEWMTVLTHFKD--LKTASFL-FVAWFMGFGIGLIFTFLFwhLQDY 536
Cdd:cd17490 156 AALAGVLGFILSLFIKEERREKKPV--------LTELKELLSVLKDkkLLFFSLLaILQQMITFSTTFGFTPLI--AKQL 225

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 537 GGTPTLFGVASVINHVSEI-FAYFFSFRLITQIGHVKVLCLGLIGNVLRFLYISYLTNPWMVLPFELMQGITHAAVWAAS 615
Cdd:cd17490 226 GASSFQLGLLSIIYLLPNAlASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLL 305

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24653694 616 CSYIAHNTPKHLRASAQGVLQGIhHGLGRGCGAIIGGMFVTYYGTTTTFrwYGIACLFVLGFFIFVNFY 684
Cdd:cd17490 306 MSLSIEGVPAEQRSTAMGFFQAI-YALGMFLGPVLVGIISEAFGLQTGF--FVIGVIALLAAILSLAYY 371
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 512-688 2.04e-09

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 59.88  E-value: 2.04e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 512 LFVAWFMGFGIGLIFTFLFWHLQDYGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLRFLYISYL 591
Cdd:cd17477   2 LLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 592 TNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVlqgihHGLGRGCGAIIGGMFVTYYGTTTTFRWYGIAC 671
Cdd:cd17477  82 DSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGL-----YSTVLGLGFALGPLLLALVGTAGALPFLIAAV 156

                       170
                ....*....|....*..
gi 24653694 672 LFVLGfFIFVNFYRKEQ 688
Cdd:cd17477 157 LLLLA-LVPLLLTRRAA 172
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 440-680 4.70e-09

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 59.14  E-value: 4.70e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 440 LAAQLNLPSLAVGSGSAASGACaggVSSFLATGHQPQPHIGAESKVFAqtakelpewmtvLTHFKDLKTASFLFVAWFMG 519
Cdd:cd17489 143 LYQHLGFAVLFIVAAVLALLAL---LLVFLVKDPPPVAAEEAEAGTRA------------FRRLVEKKVLPPALILFLAS 207

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 520 FGIGLIFTFLFWHLQDYGgtPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLRFLYISYLTNPWMVLP 599
Cdd:cd17489 208 IAYGAISTFLPLYAAERG--ISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLL 285

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 600 FELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLqGIHHGLGRGCGAIIGGMFVTYYGTTTTFRWYGIACLFVLGFFI 679
Cdd:cd17489 286 AAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTF-FIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364


                .
gi 24653694 680 F 680
Cdd:cd17489 365 F 365
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 512-683 7.02e-09

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 57.90  E-value: 7.02e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 512 LFVAWFM-GFGIGLIFTFLFWHLQDYGGTPTLFGVASVinhvseifAYFFSF--------RLITQIGHVKVLCLGLIGNV 582
Cdd:COG0477  19 LALGTFLeGLDFTIVNVALPSIAADLGASSAQLGWIVS--------AYLLGRaiglllfgRLGDRYGRKRVLLIGLLLFG 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 583 LRFLYISYLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLQGIhHGLGRGCGAIIGGMFVTYYGttt 662
Cdd:COG0477  91 LASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAA-IGLGLALGPLLGGLLVAALG--- 166

                       170       180
                ....*....|....*....|..
gi 24653694 663 tFRW-YGIACLFVLGFFIFVNF 683
Cdd:COG0477 167 -WRWiFLINAPLGLLALVLRLR 187
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
509-686 1.09e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 57.96  E-value: 1.09e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 509 ASFLFVAWFMGFGIGLIFTFLFW---HLQD-YGGTPTLFGVASVINHVSEIFAYFFSFRLITQIG--HVKVLCLGLIGNV 582
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWlptYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAA 259

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 583 LRFLYISYLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLQGIhHGLGRGCGAIIGGMFVTYYGTTT 662
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTF-GFLGGALGPLLVGYLLDATGYQA 338

                       170       180
                ....*....|....*....|....
gi 24653694 663 TFrwYGIACLFVLGFFIFVNFYRK 686
Cdd:COG2271 339 AF--LLLAALALLAALLALLLLRE 360
MFS_NHS cd06177
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ...
 455-677 2.20e-08

Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340866 [Multi-domain]  Cd Length: 386  Bit Score: 56.87  E-value: 2.20e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 455 SAASGACAGGVSSFLatghqpqPHIGAESKVFAQTAKELpEWMTVLTHFKDLKTASFLFVAWFMGFGIGLIFTFLFWHLQ 534
Cdd:cd06177 156 AAGASLLLGLYSLTL-------PHTPPKKAGKGVSKRSL-LGLDAFVLLKNPFFAVFFIFSFLLGAPLQFYYTFANPFLN 227

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 535 DYGGTPTLFGVASVINHVSEIFAY----FFSFRLitqiGHVKVLCLGLIGNVLRFLYISYlTNP----WMVLPFELMQGI 606
Cdd:cd06177 228 DFGMIVKNPAGIMSLGQISEILFMlaipFFLKRL----GIKKVMLIGMLAWVLRFGLFAY-GDPspgvWMLVLSIILHGV 302

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 607 THAAVWAASCSYIAHNTPKHLRASAQGVLQGIHHGLGRGCGAIIGGMFVTYYGTT-TTFRWYGI-----------ACLFV 674
Cdd:cd06177 303 CYDFFFVTGYIYVDKKAPKDIRASAQGLFMLMTNGVGALVGSILSGKVVDKFTTVeGTKDWQTIwlvpaiyalvlAILFA 382


                ...
gi 24653694 675 LGF 677
Cdd:cd06177 383 LFF 385
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
508-681 2.44e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 56.81  E-value: 2.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 508 TASFLFVAWFMGFGIGLIFTFLFWHL-QDYGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLRFL 586
Cdd:COG2223   6 VLLLATLAFFLAFGVWYLWSVLAPPLaEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 587 YISYLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLQGIhHGLGRGCGAIIGGMFVTYYGTTTTFRW 666
Cdd:COG2223  86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGG-GNLGAAVAAFLAPLLIAAFGWRNAFLI 164

                       170
                ....*....|....*
gi 24653694 667 YGIACLFVLGFFIFV 681
Cdd:COG2223 165 LGILLLVVAVLAWLF 179
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 509-681 2.88e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 56.45  E-value: 2.88e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 509 ASFLFvawFMGFGIGLIFTFLFwhLQDYGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLRFLYI 588
Cdd:cd17489   4 ANFFF---FLSFYLLLPVLPLY--AHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLY 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 589 SYLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGvLQGIHHGLGRGCGAIIGGMFVTYYGTTTTFRWYG 668
Cdd:cd17489  79 LLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIG-YYGLATTLAMALGPALGLFLYQHLGFAVLFIVAA 157

                       170
                ....*....|...
gi 24653694 669 IACLFVLGFFIFV 681
Cdd:cd17489 158 VLALLALLLVFLV 170
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 485-680 1.30e-07

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 54.47  E-value: 1.30e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 485 VFAQTAKELPEWMTVLTHFKDLKTAS-----FLFVAWFMGFGiGLIFTFLFWHLQDYGGTPTL-FGVASVINHVSEIFAY 558
Cdd:cd17370 174 LFVVKEYPRPPKLRKKSKKTSLKKLPkafwlYLLAVALFALG-NFSFAFLILRAQELGLSAALiPLLYALFNLVYALAAY 252

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 559 FFSfRLITQIGHVKVLCLGLIGNVLRFLYISYLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLqgi 638
Cdd:cd17370 253 PAG-RLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLF--- 328

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 24653694 639 hhGLGRGCGAIIG----GMFVTYYGTTTTFrWYGIACLFVLGFFIF 680
Cdd:cd17370 329 --NTVVGIGWLLAsliaGYLWDLISPSAAF-LFSAVLALIALLLLL 371
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 511-680 2.07e-07

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 53.74  E-value: 2.07e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 511 FLFVAWFMGFG-IGLIFTFLFWHLQDYGGTPTLFGVASVINHVSEIFAYFFSFRLITQ-IGHVKVLCLGLIGNVLRFLYI 588
Cdd:cd17330 179 LLLVYFLIALAfAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKrLGERKLLRLGLLLAIIGLLLL 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 589 SYLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLQGIhHGLGRGCGAIIGGMFVTYYGTTTTFrwYG 668
Cdd:cd17330 259 PFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSL-QSLARIIGPLLAGPLYSFLGPGVPF--LL 335

                       170
                ....*....|..
gi 24653694 669 IACLFVLGFFIF 680
Cdd:cd17330 336 AAGLLLIALFLL 347
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 456-680 3.51e-07

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 53.00  E-value: 3.51e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 456 AASGACAGGVSSFLATGHQPQPHIGAESKVFAQTAKElpEWMTVLTHFKDLKTAsFLFVAWFMGFGIGLIFTFLFWHLQD 535
Cdd:cd06173 162 AINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLR--EGLRYLRRSPLLRLL-LLALALFALLGGALTVLLPLLAKEV 238

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 536 YGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLRFLYISYLTNPWMVLPFELMQGITHAAVWAAS 615
Cdd:cd06173 239 LGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPL 318

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24653694 616 CSYIAHNTPKHLRASAQGVLQGIHHGLGRGcGAIIGGMFVTYYGTTTTFRWYGIACLFVLGFFIF 680
Cdd:cd06173 319 NTLLQLRVPDELRGRVFSVYNALNSGAMPL-GALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 519-684 4.08e-07

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 52.97  E-value: 4.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 519 GFGIGLIFTFLFWHLQDY---GGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLRFLYISYLTNPW 595
Cdd:cd17330   9 ALGFGIVFPVLPFYVREFnklGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLW 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 596 MVLPFELMQGITHAAVWAAScSYIAHNTPKHLRASAQGVLQGIhHGLGRGCGAIIGGMFVTYYGTTTTFRwygIACLFVL 675
Cdd:cd17330  89 LLFLARFLDGLTGGNVSVAQ-AYIADITDEEERAKAFGIISAA-FGLGFILGPALGGFLSTPYGYALPFL---VAAALAL 163


                ....*....
gi 24653694 676 GFFIFVNFY 684
Cdd:cd17330 164 LNLVLVLFF 172
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 517-683 1.23e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 51.46  E-value: 1.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 517 FMGFGIGLIFTFLFWHL-QDYGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLRFLYISYLTNPW 595
Cdd:cd17329  10 LNRLGFFMVWPFMAIYLhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPW 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 596 MVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQgVLQGIHHGLGRGCGAIIGGMFVTYYGTTTTfrWYGIACLFVL 675
Cdd:cd17329  90 LFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAF-SLLYWAINLGVAIGPLLGGLLLLYSFRLLF--LAAAVLFLLA 166


                ....*...
gi 24653694 676 GFFIFVNF 683
Cdd:cd17329 167 ALVLLFLL 174
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 503-680 1.56e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 47.95  E-value: 1.56e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 503 FKDLKTASFLFVAWFMGFGIGLIFTFLFWHL-QDYGGTPT----LFGVASVinhVSEIFAYFFSFRLITQIGHVKVLCLG 577
Cdd:cd17474 195 LRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLeLLYGISPIiiglLFAGWSV---LLALGSLFVGRLLKKRFGARRILVIG 271

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 578 LIGNVLRFLYISYLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLQGIhHGLGRGCGAIIGGMFVTY 657
Cdd:cd17474 272 LLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFV-RFLGQAVGPLLFGLLLEI 350

                       170       180
                ....*....|....*....|...
gi 24653694 658 YGTTTTFrWYGIACLFVLGFFIF 680
Cdd:cd17474 351 FGLSAPF-LVGAAIALAAAVLLA 372
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 512-683 1.89e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 47.64  E-value: 1.89e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 512 LFVAWFM----GFGIGLIFTFLFWHL-QDYGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLRFL 586
Cdd:cd17391 206 LFVTTFIiqlaNQSIEPILTLYIRQLmGDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYI 285

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 587 YISYLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLQGIHHgLGRGCGAIIGGMFVTYYGTTTTFrw 666
Cdd:cd17391 286 PQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQY-LGNVAGPLLGSAIAAHFGYRAVF-- 362

                       170
                ....*....|....*...
gi 24653694 667 YGIACLFVLG-FFIFVNF 683
Cdd:cd17391 363 VVTALLVLLNaIWSFIFL 380
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 482-670 1.98e-05

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 47.52  E-value: 1.98e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 482 ESKVFAQTAKE-----LPEWMTVLTHFKDLKTASFLFVAWFMGFGIGLIFTfLFWHLQDYGGTPTLFGVASVINHVSEIF 556
Cdd:cd17369 201 ETPVFRRAKEAgqvvrAPLVEVLRRHWRALLLAIGLRLAENVLFYLFTTFA-LSYATQTLGVDRSTVLLAVLIASVVAAI 279

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 557 AYFFSFRLITQIGHVKVLCLGLIGNVLR----FLYISYLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASaq 632
Cdd:cd17369 280 TIPLFGWLSDRVGRRPVYLAGALLAALFafpfFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYT-- 357

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 24653694 633 GVlqgihhGLGRGCGAIIGGMFVTYYGT---TTTFRWYGIA 670
Cdd:cd17369 358 GA------SLGYQLGAILGGGFAPLIATalvAATGSWWPVA 392
MFS_unc93_like cd17338
Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is ...
 519-679 2.42e-05

Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is composed of Caenorhabditis elegans uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93) and similar proteins including three vertebrate members: protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET). Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The human UNC93A gene is located in a region of the genome that is frequently associated with ovarian cancer, however, there is no evidence that UNC93A has a tumor suppressor function. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons. The unc93-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340896 [Multi-domain]  Cd Length: 388  Bit Score: 47.34  E-value: 2.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 519 GFGIGLIFTFlFWHLQDYGGTPTLFGVAS---VINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLrFLYISYLTNPW 595
Cdd:cd17338   5 SFGFLLIFLA-YSALQNLQTSLHENGLGSislGILYSSFAVSSFIAPLLVKLLGEKITLVLGGLGYAI-FIASNIFPIWG 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 596 MVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLQGIHHgLGRGCGAIIGGMFVTYY----GTTTTFRWYGI-- 669
Cdd:cd17338  83 TLVPASIILGFAAAILWTAQGTYITRISDESNIGRNFGIFWSIFQ-LSQVFGNLISLALLNHSkgssGTTILFIVFMAim 161

                       170
                ....*....|
gi 24653694 670 ACLFVLGFFI 679
Cdd:cd17338 162 LVGIILLFFL 171
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
511-689 5.42e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 46.41  E-value: 5.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 511 FLFVAWFMGFGIGLIFTF---LFWHLQdYGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLRFLY 587
Cdd:COG2223 209 LLSLLYFGTFGSFIGFSSwlpPYLVDQ-FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLL 287

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 588 ISYLT-NPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLQGIhHGLGRGCGAIIGGMFVTYYGTTTTFrW 666
Cdd:COG2223 288 LALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAA-GGLGGFLGPLLFGALLDATGSYTAA-F 365

                       170       180
                ....*....|....*....|...
gi 24653694 667 YGIACLFVLGFFIFVNFYRKEQG 689
Cdd:COG2223 366 LVFAVLALVALVLTLLLYRRPRR 388
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 563-659 8.14e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 45.63  E-value: 8.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 563 RLITQIGHVKVLCLGLIGNVLRFLYISYLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLqGIHHGL 642
Cdd:cd17321  53 RLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLW-GAVVGI 131

                        90
                ....*....|....*..
gi 24653694 643 GRGCGAIIGGMFVTYYG 659
Cdd:cd17321 132 GAALGPLLGGLLLELFG 148
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 517-684 9.55e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 45.30  E-value: 9.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 517 FMGFGIGLIFTFLFW---------HLQD-YGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLRFL 586
Cdd:cd17329 202 FLLFLLASFLISLIYfqlestlpvYVVEiLGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFA 281

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 587 YISYLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVlQGIHHGLGRGCGAIIGGMFVTYYGttTTFRW 666
Cdd:cd17329 282 VLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGF-YALAWGLGRAIGPLVGGLLLDLLG--PGLPW 358

                       170
                ....*....|....*...
gi 24653694 667 YGIACLFVLGFFIFVNFY 684
Cdd:cd17329 359 LILAALGLIAAALLLGLQ 376
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 487-681 1.09e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 45.26  E-value: 1.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 487 AQTAKELPEWMTVLTHFKDLKTASFLFVAWFMGF-GIGLIFTFLFWHLQD-YGGTPTLFGVA-SVINHVSEIFAYFFSfR 563
Cdd:cd17473 177 ARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMlLFYVIPIQLPFLLQErGGGSAALIGLAlAIASLAGAIGALLFG-R 255

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 564 LITQIGHVKVLCLGLIGNVLRFLYISYLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLQgihhglg 643
Cdd:cd17473 256 LKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVT------- 328

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 24653694 644 rgcGAIIGGMFVT----------YYGTTTTFRWYGIACLFVLGFFIFV 681
Cdd:cd17473 329 ---SAFFLGQFLSplvlgplvnlTGGLSGAFLILGVLALVLAIVLLLL 373
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 511-680 3.26e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 43.74  E-value: 3.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 511 FLFVAWFM-GFGIGLIFTFL--FWHLQDYGGTPTL-FGVASVINHVSEIFAYFFSFrLITQIGHVKVLCLGLIGNVLRFL 586
Cdd:cd17316   3 LAGLGWFFdAYDFFLIGFVApvLAAEFSLGLSLLQtGLLFAAGFLGRPIGALLFGY-LGDRIGRKKALILTLLLFGLATL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 587 YISYLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLQGIhHGLGRGCGAIIGGMFVTYYGTTTTFRW 666
Cdd:cd17316  82 LIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSG-WALGALLAALVASLLIPLLSGDWGWRI 160

                       170
                ....*....|....*
gi 24653694 667 -YGIACLFVLGFFIF 680
Cdd:cd17316 161 lFLIGALPALLALLL 175
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 506-681 5.78e-04

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 42.95  E-value: 5.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 506 LKTASFLFVAWFMGFGIGLIFTFL----FWHLQDYGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVL----CLG 577
Cdd:cd17320 198 LKNRRFLGYALALGLSFAGLFAYLaaapFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLrlglLLL 277

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 578 LIGNVLRFLYIS--YLTNPWMVLPFELM---QGITHA-AVWAASCSYiahntpKHLRASAQGVLQGIHHGLGRGCGAIIG 651
Cdd:cd17320 278 LAAALVLLLAALlgGLSLWPLVAPLFLIffgFGLIFPnATSLALEPF------PHVAGTASALLGFLQFLIGALAGALVG 351

                       170       180       190
                ....*....|....*....|....*....|
gi 24653694 652 gmfVTYYGTTTTFRWYGIACLFVLGFFIFV 681
Cdd:cd17320 352 ---LLPNGTALPMGLLILVLGLLALLLLIL 378
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 509-675 1.76e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 41.49  E-value: 1.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 509 ASFLFVAWFMGFGIGLIFTFLF--WHlQDYGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLRFL 586
Cdd:cd17355   5 LAVTFLILILSWGIRYYFGVFIipII-AEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLV 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 587 YISYLTNPW-MVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLqgihhGLGRGCGAI----IGGMFVTYYGTT 661
Cdd:cd17355  84 LLALATSLWqLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGIL-----TAGGGLGSLvflpLGAALIEAFGWR 158

                       170
                ....*....|....
gi 24653694 662 TTFRWYGIACLFVL 675
Cdd:cd17355 159 TALLVLALLALLVL 172
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 517-708 2.14e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 41.10  E-value: 2.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 517 FMGFGIGLIFTFLFWHLQDYGGTPTLF-----GVA-SVINHVSEIFAYFFSfRLITQIGHVKVLCLGLIGNVLRFLYISY 590
Cdd:cd17391   7 FTGIGFSLIAPFLPLYIEQLGVTSGGLvelwsGLAfSSTFLVSAIFSPIWG-RLADRYGRKPMLLRASLGMAIVIGLMAF 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 591 LTNPWMVLPFELMQGITHAAVwAASCSYIAHNTPKHLRASAQGVLQGihhGLGRGC--GAIIGGMFVTYYGTTTTFrwyg 668
Cdd:cd17391  86 VTNVWQLLILRLLQGVFSGYV-PNATALIASQTPKEKSGWALGTLST---GVVAGTliGPLLGGFLADLFGIRNVF---- 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 24653694 669 iaclFVLGFFIFVNFyrkeqgFISEIPVTEDPHQVAEETS 708
Cdd:cd17391 158 ----FITGGLLFLAF------LLTLFFVKEDFKPVEKKKM 187
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 508-697 2.17e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 41.07  E-value: 2.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 508 TASFLFVAwFMGFGIGLIFTFLfwhLQDYGGTPTLFG-VASVINhVSEIFAYFFSFRLITQIGHVKVLCLGLIGNVLRFL 586
Cdd:cd17475   2 TLAQAAAS-LVAQGIPALAPFL---QEDLHLSLAQVGlLLSALN-LGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAAL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 587 YISYLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLQ-GIhhGLGRGCGAIIGGMFVTYYGTTTTFR 665
Cdd:cd17475  77 LMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQtGV--PLGGALAAALLPPLALHYGWRAAFV 154

                       170       180       190
                ....*....|....*....|....*....|..
gi 24653694 666 WYGIAClfVLGFFIFVNFYRKEQGFISEIPVT 697
Cdd:cd17475 155 VAGLVS--ILAAVLFWLFYREPPAASAATESA 184
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 511-679 2.20e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 41.06  E-value: 2.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 511 FLFVAWFMGFGIGLIFTFLFWHLQDYGGTPTLFGVASVINHVSEIFAYFFSFRLITQIGHVKVLCLGLIGN-----VLRF 585
Cdd:cd06173   4 LWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRallaaVLAL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 586 LYISYLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLQGIhHGLGRGCGAIIGGMFVTYYGTTTTFr 665
Cdd:cd06173  84 LALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLA-TQLARIIGPALGGLLVALLGPGGAF- 161

                       170
                ....*....|....
gi 24653694 666 wYGIACLFVLGFFI 679
Cdd:cd06173 162 -AINALSFLLSALL 174
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
511-681 2.85e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 40.61  E-value: 2.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 511 FLFVAWFMGFGI-GLIFTFLFWHLQDYGGTP--------TLFGVASVInhvseifAYFFSFRLITQIGHVKVLCLGLIGN 581
Cdd:COG0738 214 LGGLAIFLYVGAeGAIGDWLPLYLKDVLGLSeataalglSLFWGGMTI-------GRFLGGFLLKRFGPVRLLRLSALLA 286

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 582 VLRFLYISYLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHLRASAQGVLqgihhglgrgCGAIIGGMFVTY---- 657
Cdd:COG0738 287 AVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVL----------IMGIVGGAIGPPligf 356

                       170       180
                ....*....|....*....|....*...
gi 24653694 658 ----YGTTTTFrWYGIACLFVLGFFIFV 681
Cdd:COG0738 357 ladaFGLRAAF-LVPLVCYLLILLLALA 383
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 487-680 3.47e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 40.61  E-value: 3.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 487 AQTAKELPEWMTVLTHFKDLKTASFLFVAWFMGFGIGLIFTFLFWHLQDYGGTPT--------LFGVASVINhvseifAY 558
Cdd:cd17324 179 PKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSsaiiglllLFGVAGVVG------SP 252

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 559 FFSfRLITQIGHVKVLCLGLIGNVLRFLYISYLTNPWMVLPFELMQGITHAAVWAASCSYIAHNTPKHlRASAQGVLQGI 638
Cdd:cd17324 253 LAG-RLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAA 330

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 24653694 639 HHgLGRGCGAIIGGMFVTYYGTTTTFrwYGIACLFVLGFFIF 680
Cdd:cd17324 331 YN-LGGALGAALGGLVLDHGGWAGVG--WVGAALLLLALLLA 369
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 563-680 5.27e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 39.93  E-value: 5.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 563 RLITQIGHVKVLCLGLIGNVLRFLYISYLTNPWMVLPFELMQGITHAAVWAAScSYIAHNTPKHLRASAQGVLqGIHHGL 642
Cdd:cd17388  60 ALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAA-AYIADVTPPEQRARNFGLL-GAAFGL 137

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 24653694 643 GRGCGAIIGGmFVTYYGTTTTFRWYGIACL--FVLGFFIF 680
Cdd:cd17388 138 GFIAGPALGG-LLGEISPRAPFLVAAGLNGlnFLLGLFVL 176
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 130-198 9.05e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 39.13  E-value: 9.05e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653694 130 LFPLMGVYF-KQMGMNPGQCGILVGMRPFVEFLSAPFWGSYADRcRQGKRLLLGSLACWVLFTIPLSFIR 198
Cdd:cd17329  18 VWPFMAIYLhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADR-FGRKPVMLAGLLLRALGFALLGFAH 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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