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Conserved domains on  [gi|19922060|ref|NP_610720|]
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uncharacterized protein Dmel_CG8321, isoform A [Drosophila melanogaster]

Protein Classification

ARL6IP6 domain-containing protein( domain architecture ID 10633374)

ARL6IP6 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ARL6IP6 pfam15062
Haemopoietic lineage transmembrane helix; ADP-ribosylation factor-like protein 6-interacting ...
 109-194 8.97e-52

Haemopoietic lineage transmembrane helix; ADP-ribosylation factor-like protein 6-interacting protein 6 (ARP6) is a transmembrane helix present in the J2E erythro-leukaemic cell line, but not its myeloid variants. In tissues, ARL-6 mRNA was most abundant in brain and kidney. While ARL-6 protein was predominantly cytosolic, it is known to bind to SEC61-beta subunit of a protein conducting channel SEC61p.


:

Pssm-ID: 405709  Cd Length: 86  Bit Score: 161.55  E-value: 8.97e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922060   109 QVLSHQVQSRWNETLVWATRHQLGSRLSPLLCGLLVAAFAYGIVYLDSAVPGVNPPSPFTPRSKKRFREEKTASMHLGYL 188
Cdd:pfam15062   1 QQLSQYVQSHWNAALDWSELHQLGSKLSPLLCGLLVASFSYGIVYLDSAVPGVFPPSPFSPRSKSRYRKLKGSSLHLGYL 80


                  ....*.
gi 19922060   189 CALFCG 194
Cdd:pfam15062  81 CALLNG 86
 
Name Accession Description Interval E-value
ARL6IP6 pfam15062
Haemopoietic lineage transmembrane helix; ADP-ribosylation factor-like protein 6-interacting ...
 109-194 8.97e-52

Haemopoietic lineage transmembrane helix; ADP-ribosylation factor-like protein 6-interacting protein 6 (ARP6) is a transmembrane helix present in the J2E erythro-leukaemic cell line, but not its myeloid variants. In tissues, ARL-6 mRNA was most abundant in brain and kidney. While ARL-6 protein was predominantly cytosolic, it is known to bind to SEC61-beta subunit of a protein conducting channel SEC61p.


Pssm-ID: 405709  Cd Length: 86  Bit Score: 161.55  E-value: 8.97e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922060   109 QVLSHQVQSRWNETLVWATRHQLGSRLSPLLCGLLVAAFAYGIVYLDSAVPGVNPPSPFTPRSKKRFREEKTASMHLGYL 188
Cdd:pfam15062   1 QQLSQYVQSHWNAALDWSELHQLGSKLSPLLCGLLVASFSYGIVYLDSAVPGVFPPSPFSPRSKSRYRKLKGSSLHLGYL 80


                  ....*.
gi 19922060   189 CALFCG 194
Cdd:pfam15062  81 CALLNG 86
 
Name Accession Description Interval E-value
ARL6IP6 pfam15062
Haemopoietic lineage transmembrane helix; ADP-ribosylation factor-like protein 6-interacting ...
 109-194 8.97e-52

Haemopoietic lineage transmembrane helix; ADP-ribosylation factor-like protein 6-interacting protein 6 (ARP6) is a transmembrane helix present in the J2E erythro-leukaemic cell line, but not its myeloid variants. In tissues, ARL-6 mRNA was most abundant in brain and kidney. While ARL-6 protein was predominantly cytosolic, it is known to bind to SEC61-beta subunit of a protein conducting channel SEC61p.


Pssm-ID: 405709  Cd Length: 86  Bit Score: 161.55  E-value: 8.97e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922060   109 QVLSHQVQSRWNETLVWATRHQLGSRLSPLLCGLLVAAFAYGIVYLDSAVPGVNPPSPFTPRSKKRFREEKTASMHLGYL 188
Cdd:pfam15062   1 QQLSQYVQSHWNAALDWSELHQLGSKLSPLLCGLLVASFSYGIVYLDSAVPGVFPPSPFSPRSKSRYRKLKGSSLHLGYL 80


                  ....*.
gi 19922060   189 CALFCG 194
Cdd:pfam15062  81 CALLNG 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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