NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24652832|ref|NP_610709|]
View 

cutoff [Drosophila melanogaster]

Protein Classification

DXO/RAI1 family protein( domain architecture ID 6952)

DXO/RAI1 family protein such as Drosophila melanogaster protein cutoff that is part of the Rhino-Deadlock-Cutoff (RDC) complex that stimulates piRNA biogenesis from chromatin regions corresponding to dual-strand, but not single-stranded, piRNA clusters

Gene Ontology:  GO:0006396|GO:0110155
PubMed:  26101253|22961381

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RAI1 super family cl07321
RAI1 like PD-(D/E)XK nuclease; RAI1 is homologous to Caenorhabditis elegans DOM-3 and human ...
 257-284 4.97e-04

RAI1 like PD-(D/E)XK nuclease; RAI1 is homologous to Caenorhabditis elegans DOM-3 and human DOM3Z and binds to a nuclear exoribonuclease. It is required for 5.8S rRNA processing. Profile-profile comparison tools demonstrate this to be a PD-(D/E)XK nuclease, with a full set of canonical active site signature motifs characteriztic to the PD-(D/E)XK nuclease superfamily.


The actual alignment was detected with superfamily member pfam08652:

Pssm-ID: 462550  Cd Length: 69  Bit Score: 38.27  E-value: 4.97e-04
                          10        20
                  ....*....|....*....|....*...
gi 24652832   257 LKWWVKCFLLGIESLYIARRDENAHVHN 284
Cdd:pfam08652  42 LKWWAQSFLVGVPRIIVGFRDDDGILRS 69
DUF6454 super family cl45434
Family of unknown function (DUF6454); This family of proteins is functionally uncharacterized. ...
 32-69 7.31e-03

Family of unknown function (DUF6454); This family of proteins is functionally uncharacterized. This family of proteins is found primarily in bacteria. Proteins in this family are typically between 294 and 372 amino acids in length.


The actual alignment was detected with superfamily member pfam20055:

Pssm-ID: 437887  Cd Length: 292  Bit Score: 37.77  E-value: 7.31e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 24652832    32 NGWFAWSPIGQFEPNSQKVPYVVVPPSIKFPISLRYKD 69
Cdd:pfam20055 105 DGEYIWVPVAEYRPNSQSIIYKVNPVTLKATEVIRFKD 142
 
Name Accession Description Interval E-value
RAI1 pfam08652
RAI1 like PD-(D/E)XK nuclease; RAI1 is homologous to Caenorhabditis elegans DOM-3 and human ...
 257-284 4.97e-04

RAI1 like PD-(D/E)XK nuclease; RAI1 is homologous to Caenorhabditis elegans DOM-3 and human DOM3Z and binds to a nuclear exoribonuclease. It is required for 5.8S rRNA processing. Profile-profile comparison tools demonstrate this to be a PD-(D/E)XK nuclease, with a full set of canonical active site signature motifs characteriztic to the PD-(D/E)XK nuclease superfamily.


Pssm-ID: 462550  Cd Length: 69  Bit Score: 38.27  E-value: 4.97e-04
                          10        20
                  ....*....|....*....|....*...
gi 24652832   257 LKWWVKCFLLGIESLYIARRDENAHVHN 284
Cdd:pfam08652  42 LKWWAQSFLVGVPRIIVGFRDDDGILRS 69
DUF6454 pfam20055
Family of unknown function (DUF6454); This family of proteins is functionally uncharacterized. ...
 32-69 7.31e-03

Family of unknown function (DUF6454); This family of proteins is functionally uncharacterized. This family of proteins is found primarily in bacteria. Proteins in this family are typically between 294 and 372 amino acids in length.


Pssm-ID: 437887  Cd Length: 292  Bit Score: 37.77  E-value: 7.31e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 24652832    32 NGWFAWSPIGQFEPNSQKVPYVVVPPSIKFPISLRYKD 69
Cdd:pfam20055 105 DGEYIWVPVAEYRPNSQSIIYKVNPVTLKATEVIRFKD 142
 
Name Accession Description Interval E-value
RAI1 pfam08652
RAI1 like PD-(D/E)XK nuclease; RAI1 is homologous to Caenorhabditis elegans DOM-3 and human ...
 257-284 4.97e-04

RAI1 like PD-(D/E)XK nuclease; RAI1 is homologous to Caenorhabditis elegans DOM-3 and human DOM3Z and binds to a nuclear exoribonuclease. It is required for 5.8S rRNA processing. Profile-profile comparison tools demonstrate this to be a PD-(D/E)XK nuclease, with a full set of canonical active site signature motifs characteriztic to the PD-(D/E)XK nuclease superfamily.


Pssm-ID: 462550  Cd Length: 69  Bit Score: 38.27  E-value: 4.97e-04
                          10        20
                  ....*....|....*....|....*...
gi 24652832   257 LKWWVKCFLLGIESLYIARRDENAHVHN 284
Cdd:pfam08652  42 LKWWAQSFLVGVPRIIVGFRDDDGILRS 69
DUF6454 pfam20055
Family of unknown function (DUF6454); This family of proteins is functionally uncharacterized. ...
 32-69 7.31e-03

Family of unknown function (DUF6454); This family of proteins is functionally uncharacterized. This family of proteins is found primarily in bacteria. Proteins in this family are typically between 294 and 372 amino acids in length.


Pssm-ID: 437887  Cd Length: 292  Bit Score: 37.77  E-value: 7.31e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 24652832    32 NGWFAWSPIGQFEPNSQKVPYVVVPPSIKFPISLRYKD 69
Cdd:pfam20055 105 DGEYIWVPVAEYRPNSQSIIYKVNPVTLKATEVIRFKD 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH