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Conserved domains on  [gi|24585481|ref|NP_610051|]
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uncharacterized protein Dmel_CG9316 [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1563018)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AMN1 super family cl39120
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 310-411 2.24e-06

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


The actual alignment was detected with superfamily member cd09293:

Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 48.48  E-value: 2.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585481 310 LTHLHLSGQFNITNEHARCLGQLSSLtDLRfsNNDILDDDhFKFFNDLSQLERFGLTACGRVMDVGMMRMLRKCPQLKVI 389
Cdd:cd09293   8 LHKLGQITQSNISQLLRILHSGLEWL-ELY--MCPISDPP-LDQLSNCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVL 83

                        90       100
                ....*....|....*....|..
gi 24585481 390 DLTDCEQITEEFVIQAIGFCSK 411
Cdd:cd09293  84 DLRACENITDSGIVALATNCPK 105
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
199-366 3.00e-06

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 3.00e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585481 199 GQNLCGFPNLKTLVLRDCLLWNSMEFGIPLKSLHTLDLDDCCFEVMNVSLyqkiaESCTNLVELIFSGCD-TNF-EVIAN 276
Cdd:COG4886 129 PEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEEL-----GNLTNLKELDLSNNQiTDLpEPLGN 203

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585481 277 LPKLERCTL-KTWMTSNELNIGFLTvlaekrgnKLTHLHLSGQfNITNehARCLGQLSSLTDLRFSNNDILDddhFKFFN 355
Cdd:COG4886 204 LTNLEELDLsGNQLTDLPEPLANLT--------NLETLDLSNN-QLTD--LPELGNLTNLEELDLSNNQLTD---LPPLA 269

                       170
                ....*....|.
gi 24585481 356 DLSQLERFGLT 366
Cdd:COG4886 270 NLTNLKTLDLS 280
 
Name Accession Description Interval E-value
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 310-411 2.24e-06

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 48.48  E-value: 2.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585481 310 LTHLHLSGQFNITNEHARCLGQLSSLtDLRfsNNDILDDDhFKFFNDLSQLERFGLTACGRVMDVGMMRMLRKCPQLKVI 389
Cdd:cd09293   8 LHKLGQITQSNISQLLRILHSGLEWL-ELY--MCPISDPP-LDQLSNCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVL 83

                        90       100
                ....*....|....*....|..
gi 24585481 390 DLTDCEQITEEFVIQAIGFCSK 411
Cdd:cd09293  84 DLRACENITDSGIVALATNCPK 105
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
199-366 3.00e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 3.00e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585481 199 GQNLCGFPNLKTLVLRDCLLWNSMEFGIPLKSLHTLDLDDCCFEVMNVSLyqkiaESCTNLVELIFSGCD-TNF-EVIAN 276
Cdd:COG4886 129 PEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEEL-----GNLTNLKELDLSNNQiTDLpEPLGN 203

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585481 277 LPKLERCTL-KTWMTSNELNIGFLTvlaekrgnKLTHLHLSGQfNITNehARCLGQLSSLTDLRFSNNDILDddhFKFFN 355
Cdd:COG4886 204 LTNLEELDLsGNQLTDLPEPLANLT--------NLETLDLSNN-QLTD--LPELGNLTNLEELDLSNNQLTD---LPPLA 269

                       170
                ....*....|.
gi 24585481 356 DLSQLERFGLT 366
Cdd:COG4886 270 NLTNLKTLDLS 280
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
245-399 4.69e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.23  E-value: 4.69e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585481 245 NVSLYQKIAESCTNLVELIFSGCDTnfevIANLPKLERCTL-KTWMTSNELNIGFLTvlaekrgnKLTHLHLSGQfNITN 323
Cdd:COG4886  84 LLLLGLTDLGDLTNLTELDLSGNEE----LSNLTNLESLDLsGNQLTDLPEELANLT--------NLKELDLSNN-QLTD 150

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24585481 324 EHARcLGQLSSLTDLRFSNNDILDDDhfKFFNDLSQLERFGLTACgRVMDVGMmrMLRKCPQLKVIDLTDCeQITE 399
Cdd:COG4886 151 LPEP-LGNLTNLKSLDLSNNQLTDLP--EELGNLTNLKELDLSNN-QITDLPE--PLGNLTNLEELDLSGN-QLTD 219
 
Name Accession Description Interval E-value
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 310-411 2.24e-06

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 48.48  E-value: 2.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585481 310 LTHLHLSGQFNITNEHARCLGQLSSLtDLRfsNNDILDDDhFKFFNDLSQLERFGLTACGRVMDVGMMRMLRKCPQLKVI 389
Cdd:cd09293   8 LHKLGQITQSNISQLLRILHSGLEWL-ELY--MCPISDPP-LDQLSNCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVL 83

                        90       100
                ....*....|....*....|..
gi 24585481 390 DLTDCEQITEEFVIQAIGFCSK 411
Cdd:cd09293  84 DLRACENITDSGIVALATNCPK 105
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
199-366 3.00e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 3.00e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585481 199 GQNLCGFPNLKTLVLRDCLLWNSMEFGIPLKSLHTLDLDDCCFEVMNVSLyqkiaESCTNLVELIFSGCD-TNF-EVIAN 276
Cdd:COG4886 129 PEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEEL-----GNLTNLKELDLSNNQiTDLpEPLGN 203

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585481 277 LPKLERCTL-KTWMTSNELNIGFLTvlaekrgnKLTHLHLSGQfNITNehARCLGQLSSLTDLRFSNNDILDddhFKFFN 355
Cdd:COG4886 204 LTNLEELDLsGNQLTDLPEPLANLT--------NLETLDLSNN-QLTD--LPELGNLTNLEELDLSNNQLTD---LPPLA 269

                       170
                ....*....|.
gi 24585481 356 DLSQLERFGLT 366
Cdd:COG4886 270 NLTNLKTLDLS 280
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
202-347 7.30e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.01  E-value: 7.30e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585481 202 LCGFPNLKTLVLRDCLLWN-SMEFGiPLKSLHTLDLDDCCFEVMNVSLYQkiaesCTNLVELIFSGCD-TNF-EVIANLP 278
Cdd:COG4886 155 LGNLTNLKSLDLSNNQLTDlPEELG-NLTNLKELDLSNNQITDLPEPLGN-----LTNLEELDLSGNQlTDLpEPLANLT 228

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24585481 279 KLErctlktwmtsnELNIGF--LTVLAE-KRGNKLTHLHLSGQfNITNehARCLGQLSSLTDLRFSNNDILD 347
Cdd:COG4886 229 NLE-----------TLDLSNnqLTDLPElGNLTNLEELDLSNN-QLTD--LPPLANLTNLKTLDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
245-399 4.69e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.23  E-value: 4.69e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585481 245 NVSLYQKIAESCTNLVELIFSGCDTnfevIANLPKLERCTL-KTWMTSNELNIGFLTvlaekrgnKLTHLHLSGQfNITN 323
Cdd:COG4886  84 LLLLGLTDLGDLTNLTELDLSGNEE----LSNLTNLESLDLsGNQLTDLPEELANLT--------NLKELDLSNN-QLTD 150

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24585481 324 EHARcLGQLSSLTDLRFSNNDILDDDhfKFFNDLSQLERFGLTACgRVMDVGMmrMLRKCPQLKVIDLTDCeQITE 399
Cdd:COG4886 151 LPEP-LGNLTNLKSLDLSNNQLTDLP--EELGNLTNLKELDLSNN-QITDLPE--PLGNLTNLEELDLSGN-QLTD 219
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 205-398 4.83e-04

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 41.54  E-value: 4.83e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585481 205 FPNLKTLVLRDC-LLWNSMEFGIPLKSLHTLDLDDCcfEVMNVSLYQKIAESCTNLVELIFSGCD--TNFEVIA---NLP 278
Cdd:cd09293  27 HSGLEWLELYMCpISDPPLDQLSNCNKLKKLILPGS--KLIDDEGLIALAQSCPNLQVLDLRACEniTDSGIVAlatNCP 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585481 279 KLERCtlktwmtsnelNIGfltvlAEKRGNKLTHLHLSGqfnitneharcLGQLSS-LTDLRFSNNDILDDDHFKFFNDL 357
Cdd:cd09293 105 KLQTI-----------NLG-----RHRNGHLITDVSLSA-----------LGKNCTfLQTVGFAGCDVTDKGVWELASGC 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 24585481 358 SQ-LERFGLTACGRVMDVGMMRMLRK--CPQLKVIDLTDCEQIT 398
Cdd:cd09293 158 SKsLERLSLNNCRNLTDQSIPAILASnyFPNLSVLEFRGCPLIT 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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