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Conserved domains on  [gi|24585372|ref|NP_610019|]
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valois [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1903264)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl43672
WD40 repeat [General function prediction only];
114-362 1.38e-05

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 1.38e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585372 114 DDFLLVALGDTRLQAWSTYSKVrdsqspyclfLVGESSAHPTPISQLSvFKADPRTAVSGSADSTLNVWDLSGADMVSTY 193
Cdd:COG2319  90 GRLLASASADGTVRLWDLATGL----------LLRTLTGHTGAVRSVA-FSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585372 194 RsrsSHTDKLTGLATpaaSVD--KFVTCDRGGCARLWDVRaaapSSTCLYADASHVLSFTSAAWAAASelqgdNHIYLGD 271
Cdd:COG2319 159 T---GHSGAVTSVAF---SPDgkLLASGSDDGTVRLWDLA----TGKLLRTLTGHTGAVRSVAFSPDG-----KLLASGS 223

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585372 272 YDGKVHTLDIRVPRKLAETReyFDKGHVAQLLI--NGPHLAAmSNLPASVKVANVQAGhEFIYTHQDTHSRLTDAVWTDD 349
Cdd:COG2319 224 ADGTVRLWDLATGKLLRTLT--GHSGSVRSVAFspDGRLLAS-GSADGTVRLWDLATG-ELLRTLTGHSGGVNSVAFSPD 299

                       250
                ....*....|...
gi 24585372 350 STLITIGHGRKMV 362
Cdd:COG2319 300 GKLLASGSDDGTV 312
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
114-362 1.38e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 1.38e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585372 114 DDFLLVALGDTRLQAWSTYSKVrdsqspyclfLVGESSAHPTPISQLSvFKADPRTAVSGSADSTLNVWDLSGADMVSTY 193
Cdd:COG2319  90 GRLLASASADGTVRLWDLATGL----------LLRTLTGHTGAVRSVA-FSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585372 194 RsrsSHTDKLTGLATpaaSVD--KFVTCDRGGCARLWDVRaaapSSTCLYADASHVLSFTSAAWAAASelqgdNHIYLGD 271
Cdd:COG2319 159 T---GHSGAVTSVAF---SPDgkLLASGSDDGTVRLWDLA----TGKLLRTLTGHTGAVRSVAFSPDG-----KLLASGS 223

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585372 272 YDGKVHTLDIRVPRKLAETReyFDKGHVAQLLI--NGPHLAAmSNLPASVKVANVQAGhEFIYTHQDTHSRLTDAVWTDD 349
Cdd:COG2319 224 ADGTVRLWDLATGKLLRTLT--GHSGSVRSVAFspDGRLLAS-GSADGTVRLWDLATG-ELLRTLTGHSGGVNSVAFSPD 299

                       250
                ....*....|...
gi 24585372 350 STLITIGHGRKMV 362
Cdd:COG2319 300 GKLLASGSDDGTV 312
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 106-282 1.45e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.17  E-value: 1.45e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585372 106 VNIVRYAED-DFLLVALGDTRLQAWSTYSKVrdsqspYCLFLVGessaHPTPISQLSVFkADPRTAVSGSADSTLNVWDL 184
Cdd:cd00200  12 VTCVAFSPDgKLLATGSGDGTIKVWDLETGE------LLRTLKG----HTGPVRDVAAS-ADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585372 185 SGADMVSTYRsrsSHTDKLTGLA-TPAASVdkFVTCDRGGCARLWDVraaaPSSTCLYADASHVLSFTSAAWaaaseLQG 263
Cdd:cd00200  81 ETGECVRTLT---GHTSYVSSVAfSPDGRI--LSSSSRDKTIKVWDV----ETGKCLTTLRGHTDWVNSVAF-----SPD 146

                       170
                ....*....|....*....
gi 24585372 264 DNHIYLGDYDGKVHTLDIR 282
Cdd:cd00200 147 GTFVASSSQDGTIKLWDLR 165
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
114-362 1.38e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 1.38e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585372 114 DDFLLVALGDTRLQAWSTYSKVrdsqspyclfLVGESSAHPTPISQLSvFKADPRTAVSGSADSTLNVWDLSGADMVSTY 193
Cdd:COG2319  90 GRLLASASADGTVRLWDLATGL----------LLRTLTGHTGAVRSVA-FSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585372 194 RsrsSHTDKLTGLATpaaSVD--KFVTCDRGGCARLWDVRaaapSSTCLYADASHVLSFTSAAWAAASelqgdNHIYLGD 271
Cdd:COG2319 159 T---GHSGAVTSVAF---SPDgkLLASGSDDGTVRLWDLA----TGKLLRTLTGHTGAVRSVAFSPDG-----KLLASGS 223

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585372 272 YDGKVHTLDIRVPRKLAETReyFDKGHVAQLLI--NGPHLAAmSNLPASVKVANVQAGhEFIYTHQDTHSRLTDAVWTDD 349
Cdd:COG2319 224 ADGTVRLWDLATGKLLRTLT--GHSGSVRSVAFspDGRLLAS-GSADGTVRLWDLATG-ELLRTLTGHSGGVNSVAFSPD 299

                       250
                ....*....|...
gi 24585372 350 STLITIGHGRKMV 362
Cdd:COG2319 300 GKLLASGSDDGTV 312
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 106-282 1.45e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.17  E-value: 1.45e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585372 106 VNIVRYAED-DFLLVALGDTRLQAWSTYSKVrdsqspYCLFLVGessaHPTPISQLSVFkADPRTAVSGSADSTLNVWDL 184
Cdd:cd00200  12 VTCVAFSPDgKLLATGSGDGTIKVWDLETGE------LLRTLKG----HTGPVRDVAAS-ADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585372 185 SGADMVSTYRsrsSHTDKLTGLA-TPAASVdkFVTCDRGGCARLWDVraaaPSSTCLYADASHVLSFTSAAWaaaseLQG 263
Cdd:cd00200  81 ETGECVRTLT---GHTSYVSSVAfSPDGRI--LSSSSRDKTIKVWDV----ETGKCLTTLRGHTDWVNSVAF-----SPD 146

                       170
                ....*....|....*....
gi 24585372 264 DNHIYLGDYDGKVHTLDIR 282
Cdd:cd00200 147 GTFVASSSQDGTIKLWDLR 165
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 103-276 2.67e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.40  E-value: 2.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585372 103 EHTVNIVRYAEDDFLLVALG-DTRLQAWstyskvrDSQSPYCLFLVgesSAHPTPISQLSvFKADPRTAVSGSADSTLNV 181
Cdd:cd00200  93 TSYVSSVAFSPDGRILSSSSrDKTIKVW-------DVETGKCLTTL---RGHTDWVNSVA-FSPDGTFVASSSQDGTIKL 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585372 182 WDLSGAdmvSTYRSRSSHTDKLTGLAtPAASVDKFVTCDRGGCARLWDVRAAAPSSTClyadASHVLSFTSAAWaaaseL 261
Cdd:cd00200 162 WDLRTG---KCVATLTGHTGEVNSVA-FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL----RGHENGVNSVAF-----S 228

                       170
                ....*....|....*
gi 24585372 262 QGDNHIYLGDYDGKV 276
Cdd:cd00200 229 PDGYLLASGSEDGTI 243
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 103-255 3.70e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 3.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585372 103 EHTVNIVRYAEDD-FLLVALGDTRLQAWstyskvrDSQSPYClflVGESSAHPTPISQLSvFKADPRTAVSGSADSTLNV 181
Cdd:cd00200 135 TDWVNSVAFSPDGtFVASSSQDGTIKLW-------DLRTGKC---VATLTGHTGEVNSVA-FSPDGEKLLSSSSDGTIKL 203

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24585372 182 WDLSGADMVSTYRSrssHTDKLTGLATpaaSVDK--FVTCDRGGCARLWDVRAAAPSSTClyadASHVLSFTSAAW 255
Cdd:cd00200 204 WDLSTGKCLGTLRG---HENGVNSVAF---SPDGylLASGSEDGTIRVWDLRTGECVQTL----SGHTNSVTSLAW 269
WD40 COG2319
WD40 repeat [General function prediction only];
103-313 8.30e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.13  E-value: 8.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585372 103 EHTVNIVRYAED-DFLLVALGDTRLQAWSTYSKVrdsqspyclfLVGESSAHPTPISQLSvFKADPRTAVSGSADSTLNV 181
Cdd:COG2319 204 TGAVRSVAFSPDgKLLASGSADGTVRLWDLATGK----------LLRTLTGHSGSVRSVA-FSPDGRLLASGSADGTVRL 272

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585372 182 WDLSGADMVSTYRsrsSHTDKLTGLATpaaSVD--KFVTCDRGGCARLWDVRaaapSSTCLYADASHVLSFTSAAWAAas 259
Cdd:COG2319 273 WDLATGELLRTLT---GHSGGVNSVAF---SPDgkLLASGSDDGTVRLWDLA----TGKLLRTLTGHTGAVRSVAFSP-- 340

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 24585372 260 elqGDNHIYLGDYDGKVHTLDIRVPRKLAETREYFDKGHVAQLLINGPHLAAMS 313
Cdd:COG2319 341 ---DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS 391
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-229 7.24e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 37.70  E-value: 7.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585372  79 MLFGYGRDQMHHMsVDSANFKLQAEHT-----VNIVRYAEDDF-LLVALGDTRLQAWSTYSKvrdsqspyclFLVGESSA 152
Cdd:cd00200 149 FVASSSQDGTIKL-WDLRTGKCVATLTghtgeVNSVAFSPDGEkLLSSSSDGTIKLWDLSTG----------KCLGTLRG 217

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24585372 153 HPTPISQLsVFKADPRTAVSGSADSTLNVWDLSGADMVSTYrsrSSHTDKLTGLA-TPAASVdkFVTCDRGGCARLWD 229
Cdd:cd00200 218 HENGVNSV-AFSPDGYLLASGSEDGTIRVWDLRTGECVQTL---SGHTNSVTSLAwSPDGKR--LASGSADGTIRIWD 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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