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Conserved domains on  [gi|19921470|ref|NP_609852|]
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uncharacterized protein Dmel_CG6870, isoform A [Drosophila melanogaster]

Protein Classification

cytochrome b5-like heme/steroid binding domain-containing protein( domain architecture ID 10445738)

cytochrome b5-like heme/steroid binding domain-containing protein such as cytochrome b5, a membrane-bound hemoprotein that functions as an electron carrier for several membrane-bound oxygenases and Arabidopsis thaliana steroid-binding proteins

CATH:  3.10.120.10
Gene Ontology:  GO:0097159|GO:0016020
PubMed:  12537557|7893819

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 46-116 9.12e-31

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


:

Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 105.01  E-value: 9.12e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19921470    46 LEEVAQHDSFDDCWVVIYDRVYDVTHFLRDHPGGDDVIMDHAGRDATIAFHGTGHSGDAI-EMMKDFLIGQL 116
Cdd:pfam00173   2 LEELSKHNGDGDCWVAINGKVYDVTKFLKEHPGGEDVILSAAGKDATDAFEAIGHSEDAAeKLLKKYRIGEL 73
 
Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 46-116 9.12e-31

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 105.01  E-value: 9.12e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19921470    46 LEEVAQHDSFDDCWVVIYDRVYDVTHFLRDHPGGDDVIMDHAGRDATIAFHGTGHSGDAI-EMMKDFLIGQL 116
Cdd:pfam00173   2 LEELSKHNGDGDCWVAINGKVYDVTKFLKEHPGGEDVILSAAGKDATDAFEAIGHSEDAAeKLLKKYRIGEL 73
CYB5 COG5274
Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport ...
 42-116 2.04e-26

Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport and metabolism];


Pssm-ID: 444085 [Multi-domain]  Cd Length: 93  Bit Score: 94.72  E-value: 2.04e-26
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19921470  42 PEIALEEVAQHDSFDDCWVVIYDRVYDVTHFLRDHPGGDDVIMDHAGRDATIAFHG-TGHSGDAIEMMKDFLIGQL 116
Cdd:COG5274  16 KTYTLAEVATHNTLSDCWMAIDGNVYDLTEYIPKHPGGEAVILRWCGKDATEAFNTkHPHSPKAERLLESYRIGRL 91
PLN02252 PLN02252
nitrate reductase [NADPH]
 44-116 1.34e-21

nitrate reductase [NADPH]


Pssm-ID: 215141 [Multi-domain]  Cd Length: 888  Bit Score: 89.35  E-value: 1.34e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19921470   44 IALEEVAQHDSFDDCWVVIYDRVYDVTHFLRDHPGGDDVIMDHAGRDATIAFHGTgHSGDAIEMMKDFLIGQL 116
Cdd:PLN02252 520 YTMSEVRKHNSEDSCWIVVHGHVYDCTRFLKDHPGGADSILINAGTDCTEEFDAI-HSDKAKKMLEDYRIGEL 591
 
Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 46-116 9.12e-31

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 105.01  E-value: 9.12e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19921470    46 LEEVAQHDSFDDCWVVIYDRVYDVTHFLRDHPGGDDVIMDHAGRDATIAFHGTGHSGDAI-EMMKDFLIGQL 116
Cdd:pfam00173   2 LEELSKHNGDGDCWVAINGKVYDVTKFLKEHPGGEDVILSAAGKDATDAFEAIGHSEDAAeKLLKKYRIGEL 73
CYB5 COG5274
Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport ...
 42-116 2.04e-26

Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport and metabolism];


Pssm-ID: 444085 [Multi-domain]  Cd Length: 93  Bit Score: 94.72  E-value: 2.04e-26
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19921470  42 PEIALEEVAQHDSFDDCWVVIYDRVYDVTHFLRDHPGGDDVIMDHAGRDATIAFHG-TGHSGDAIEMMKDFLIGQL 116
Cdd:COG5274  16 KTYTLAEVATHNTLSDCWMAIDGNVYDLTEYIPKHPGGEAVILRWCGKDATEAFNTkHPHSPKAERLLESYRIGRL 91
PLN02252 PLN02252
nitrate reductase [NADPH]
 44-116 1.34e-21

nitrate reductase [NADPH]


Pssm-ID: 215141 [Multi-domain]  Cd Length: 888  Bit Score: 89.35  E-value: 1.34e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19921470   44 IALEEVAQHDSFDDCWVVIYDRVYDVTHFLRDHPGGDDVIMDHAGRDATIAFHGTgHSGDAIEMMKDFLIGQL 116
Cdd:PLN02252 520 YTMSEVRKHNSEDSCWIVVHGHVYDCTRFLKDHPGGADSILINAGTDCTEEFDAI-HSDKAKKMLEDYRIGEL 591
PLN03198 PLN03198
delta6-acyl-lipid desaturase; Provisional
 27-116 6.51e-16

delta6-acyl-lipid desaturase; Provisional


Pssm-ID: 178739 [Multi-domain]  Cd Length: 526  Bit Score: 72.80  E-value: 6.51e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921470   27 VVVPSKKERLKLEDLPEIALEEVAQHDSFDDCWVVIYDRVYDVTHFLRDHPGGdDVIMDHAGRDATIAFhGTGHSGDAIE 106
Cdd:PLN03198  89 VVKPTRRRSSKEKKSKSHLLSEVAAHNKPNDCWIVIKNKVYDVSDFAAEHPGG-SVISTYFGRDGTDAF-SSFHAASTWK 166

                         90
                 ....*....|
gi 19921470  107 MMKDFLIGQL 116
Cdd:PLN03198 167 ILQDFYIGDV 176
PLN03199 PLN03199
delta6-acyl-lipid desaturase-like protein; Provisional
 36-116 5.28e-13

delta6-acyl-lipid desaturase-like protein; Provisional


Pssm-ID: 178740 [Multi-domain]  Cd Length: 485  Bit Score: 64.67  E-value: 5.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19921470   36 LKLEDLPE-IALEEVAQHDSFDDCWVVIYDRVYDVTHFlRDHPGGdDVIMDHAGRDAT---IAFHGTGHSGdaieMMKDF 111
Cdd:PLN03199  17 LKLAEKPQkISWQEVKKHASPDDAWIIHQNKVYDVSNW-HDHPGG-AVIFTHAGDDMTdifAAFHAPGSQA----LMKKF 90


                 ....*
gi 19921470  112 LIGQL 116
Cdd:PLN03199  91 YIGDL 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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