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Conserved domains on  [gi|45550169|ref|NP_609324|]
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uncharacterized protein Dmel_CG4592, isoform A [Drosophila melanogaster]

Protein Classification

Clp protease/crotonase-like domain-containing protein( domain architecture ID 581041)

Clp protease/crotonase-like domain-containing protein similar to Oryza sativa enoyl-CoA delta isomerase which plays a role in fatty acid metabolism, which involves stabilization of an enolate anion intermediate derived from an acyl-CoA substrate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
crotonase-like super family cl23717
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 43-287 9.16e-45

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


The actual alignment was detected with superfamily member pfam00378:

Pssm-ID: 474030 [Multi-domain]  Cd Length: 251  Bit Score: 152.13  E-value: 9.16e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169    43 SGIATLSMNLP-PVNTLTMELMHDLIDSINQIESNKS-RGLILTSSnDKVFSAGLDLNEMLNPDVERLRLFWTRFQDLWL 120
Cdd:pfam00378   4 AGVAVITLNRPeAVNALSAELITELIQALEKLRTDPSvRAVVLTGG-DKAFCAGADLKEMYGEGPAHQALYRENVLDLWT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   121 ALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNLFIGIHATRFSFVISKWMMNSYQSVLPRRIVERALNQGKLFASQ 200
Cdd:pfam00378  83 LLYTCPKPVIAAVNGYAIGGGCELALACDIIIAADNASFGLNETKLGIIPGAGGTDRLPRIIGHSKAMEMLLLGRRISAQ 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   201 EALDVGLVDEIaCSKEEALSK---CAAFIAtfDKTNPVARCLTKRMCREPDvRELLQDRAADLKECVDYVTTPLFQEGLC 277
Cdd:pfam00378 163 EALKWGLVDKV-VPEDQLLDEareLAEKLA--EKSPAALAQLKKALNAKLE-DALPTQLEAEARLFYSTFSKDDIIEGLQ 238

                         250
                  ....*....|
gi 45550169   278 AHLEglkKRK 287
Cdd:pfam00378 239 AFLE---KRK 245
 
Name Accession Description Interval E-value
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 43-287 9.16e-45

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 152.13  E-value: 9.16e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169    43 SGIATLSMNLP-PVNTLTMELMHDLIDSINQIESNKS-RGLILTSSnDKVFSAGLDLNEMLNPDVERLRLFWTRFQDLWL 120
Cdd:pfam00378   4 AGVAVITLNRPeAVNALSAELITELIQALEKLRTDPSvRAVVLTGG-DKAFCAGADLKEMYGEGPAHQALYRENVLDLWT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   121 ALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNLFIGIHATRFSFVISKWMMNSYQSVLPRRIVERALNQGKLFASQ 200
Cdd:pfam00378  83 LLYTCPKPVIAAVNGYAIGGGCELALACDIIIAADNASFGLNETKLGIIPGAGGTDRLPRIIGHSKAMEMLLLGRRISAQ 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   201 EALDVGLVDEIaCSKEEALSK---CAAFIAtfDKTNPVARCLTKRMCREPDvRELLQDRAADLKECVDYVTTPLFQEGLC 277
Cdd:pfam00378 163 EALKWGLVDKV-VPEDQLLDEareLAEKLA--EKSPAALAQLKKALNAKLE-DALPTQLEAEARLFYSTFSKDDIIEGLQ 238

                         250
                  ....*....|
gi 45550169   278 AHLEglkKRK 287
Cdd:pfam00378 239 AFLE---KRK 245
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 37-287 1.26e-39

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 138.38  E-value: 1.26e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  37 IEVDDRSGIATLSMNLP-PVNTLTMELMHDLIDSINQIESNKS-RGLILTSSnDKVFSAGLDLNEML-NPDVERLRLFWT 113
Cdd:COG1024   1 VLVEREGGVATITLNRPeKLNALSLEMLAELAAALDEAEADPDvRVVVLTGA-GKAFCAGADLKELAaAADPEEARAFAR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169 114 RFQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNlfigihaTRFSFVISKW-----MMNSYqsVLPRRI-V 187
Cdd:COG1024  80 GLQRLFRALRRLPKPVIAAVNGAALGGGLELALACDLRIAAED-------ARFGLPEVRLglipgGGGTQ--RLPRLVgL 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169 188 ERALNQ---GKLFASQEALDVGLVDEIaCSKEEALSKCAAFIATFDKTNPVARCLTKRMCREPDVRELLQDRAADLKECV 264
Cdd:COG1024 151 ARAKELlltGRRIDAEEALELGLVNRV-VPDDELLAAALALAARLAAGPPLALAATKRALNAALEAPLDEALELEAEAFA 229

                       250       260
                ....*....|....*....|...
gi 45550169 265 DYVTTPLFQEGLCAHLEglkKRK 287
Cdd:COG1024 230 ELFASEDAREGIAAFLE---KRK 249
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 37-227 5.45e-38

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 132.68  E-value: 5.45e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  37 IEVDDRSGIATLSMNLPP-VNTLTMELMHDLIDSINQIESNKS-RGLILTSsNDKVFSAGLDLNEM--LNPDVERLRLFW 112
Cdd:cd06558   1 VLVERDGGVATITLNRPEkRNALSLEMLDELAAALDEAEADPDvRVVVLTG-AGKAFCAGADLKELaaLSDAGEEARAFI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169 113 TRFQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNLFIGIHATRFSFVISKWMMNSYQSVLPRRIVERALN 192
Cdd:cd06558  80 RELQELLRALLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQRLPRLVGPARARELLL 159

                       170       180       190
                ....*....|....*....|....*....|....*
gi 45550169 193 QGKLFASQEALDVGLVDEIaCSKEEALSKCAAFIA 227
Cdd:cd06558 160 TGRRISAEEALELGLVDEV-VPDEELLAAALELAR 193
PLN03214 PLN03214
probable enoyl-CoA hydratase/isomerase; Provisional
 27-246 2.90e-29

probable enoyl-CoA hydratase/isomerase; Provisional


Pssm-ID: 215635  Cd Length: 278  Bit Score: 112.28  E-value: 2.90e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   27 ANGATSKLTTIEVDDRS-GIATLSMNLPPVNTLTMELMHDLIDSINQIESNKS-RGLILTSSNDK-VFSAGLDLNEMLNP 103
Cdd:PLN03214   3 APSPPGATPGVRVDRRPgGIAVVWLAKEPVNSMTLAMWRSLDDALTALENDPTvRGVVFASGLRRdVFTAGNDIAELYAP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  104 DV--ERLRLFWTRFQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNLFIGIHATRFSFVISK-WMMNSYQS 180
Cdd:PLN03214  83 KTsaARYAEFWLTQTTFLVRLLRSRLATVCAIRGACPAGGCAVSLCCDYRLQTTEGTMGLNEVALGIPVPKfWARLFMGR 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45550169  181 VLPRRIVERALNQGKLFASQEALDVGLVDEIACSK---EEALSKCAAFIatfdKTNPVARCLTKRMCRE 246
Cdd:PLN03214 163 VIDRKVAESLLLRGRLVRPAEAKQLGLIDEVVPAAalmEAAASAMERAL----KLPSAARAATKALLRE 227
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 35-152 3.58e-07

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 51.38  E-value: 3.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169    35 TTIEVDDRSGIATLSMNLP--PVNTLTMELMHDLIDSINQIESNKS-RGLILTSSNDKVFSAGLDLNeMLNP--DVERLR 109
Cdd:TIGR02441  13 THRHYEVKGDVAVVKIDSPnsKVNTLSKELFAEFKEVMNELWTNEAiKSAVLISGKPGSFVAGADIQ-MIAAckTAQEVT 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 45550169   110 LFWTRFQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRV 152
Cdd:TIGR02441  92 QLSQEGQEMFERIEKSQKPIVAAISGSCLGGGLELALACHYRI 134
 
Name Accession Description Interval E-value
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 43-287 9.16e-45

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 152.13  E-value: 9.16e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169    43 SGIATLSMNLP-PVNTLTMELMHDLIDSINQIESNKS-RGLILTSSnDKVFSAGLDLNEMLNPDVERLRLFWTRFQDLWL 120
Cdd:pfam00378   4 AGVAVITLNRPeAVNALSAELITELIQALEKLRTDPSvRAVVLTGG-DKAFCAGADLKEMYGEGPAHQALYRENVLDLWT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   121 ALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNLFIGIHATRFSFVISKWMMNSYQSVLPRRIVERALNQGKLFASQ 200
Cdd:pfam00378  83 LLYTCPKPVIAAVNGYAIGGGCELALACDIIIAADNASFGLNETKLGIIPGAGGTDRLPRIIGHSKAMEMLLLGRRISAQ 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   201 EALDVGLVDEIaCSKEEALSK---CAAFIAtfDKTNPVARCLTKRMCREPDvRELLQDRAADLKECVDYVTTPLFQEGLC 277
Cdd:pfam00378 163 EALKWGLVDKV-VPEDQLLDEareLAEKLA--EKSPAALAQLKKALNAKLE-DALPTQLEAEARLFYSTFSKDDIIEGLQ 238

                         250
                  ....*....|
gi 45550169   278 AHLEglkKRK 287
Cdd:pfam00378 239 AFLE---KRK 245
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 37-287 1.26e-39

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 138.38  E-value: 1.26e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  37 IEVDDRSGIATLSMNLP-PVNTLTMELMHDLIDSINQIESNKS-RGLILTSSnDKVFSAGLDLNEML-NPDVERLRLFWT 113
Cdd:COG1024   1 VLVEREGGVATITLNRPeKLNALSLEMLAELAAALDEAEADPDvRVVVLTGA-GKAFCAGADLKELAaAADPEEARAFAR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169 114 RFQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNlfigihaTRFSFVISKW-----MMNSYqsVLPRRI-V 187
Cdd:COG1024  80 GLQRLFRALRRLPKPVIAAVNGAALGGGLELALACDLRIAAED-------ARFGLPEVRLglipgGGGTQ--RLPRLVgL 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169 188 ERALNQ---GKLFASQEALDVGLVDEIaCSKEEALSKCAAFIATFDKTNPVARCLTKRMCREPDVRELLQDRAADLKECV 264
Cdd:COG1024 151 ARAKELlltGRRIDAEEALELGLVNRV-VPDDELLAAALALAARLAAGPPLALAATKRALNAALEAPLDEALELEAEAFA 229

                       250       260
                ....*....|....*....|...
gi 45550169 265 DYVTTPLFQEGLCAHLEglkKRK 287
Cdd:COG1024 230 ELFASEDAREGIAAFLE---KRK 249
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 37-227 5.45e-38

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 132.68  E-value: 5.45e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  37 IEVDDRSGIATLSMNLPP-VNTLTMELMHDLIDSINQIESNKS-RGLILTSsNDKVFSAGLDLNEM--LNPDVERLRLFW 112
Cdd:cd06558   1 VLVERDGGVATITLNRPEkRNALSLEMLDELAAALDEAEADPDvRVVVLTG-AGKAFCAGADLKELaaLSDAGEEARAFI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169 113 TRFQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNLFIGIHATRFSFVISKWMMNSYQSVLPRRIVERALN 192
Cdd:cd06558  80 RELQELLRALLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQRLPRLVGPARARELLL 159

                       170       180       190
                ....*....|....*....|....*....|....*
gi 45550169 193 QGKLFASQEALDVGLVDEIaCSKEEALSKCAAFIA 227
Cdd:cd06558 160 TGRRISAEEALELGLVDEV-VPDEELLAAALELAR 193
PLN03214 PLN03214
probable enoyl-CoA hydratase/isomerase; Provisional
 27-246 2.90e-29

probable enoyl-CoA hydratase/isomerase; Provisional


Pssm-ID: 215635  Cd Length: 278  Bit Score: 112.28  E-value: 2.90e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   27 ANGATSKLTTIEVDDRS-GIATLSMNLPPVNTLTMELMHDLIDSINQIESNKS-RGLILTSSNDK-VFSAGLDLNEMLNP 103
Cdd:PLN03214   3 APSPPGATPGVRVDRRPgGIAVVWLAKEPVNSMTLAMWRSLDDALTALENDPTvRGVVFASGLRRdVFTAGNDIAELYAP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  104 DV--ERLRLFWTRFQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNLFIGIHATRFSFVISK-WMMNSYQS 180
Cdd:PLN03214  83 KTsaARYAEFWLTQTTFLVRLLRSRLATVCAIRGACPAGGCAVSLCCDYRLQTTEGTMGLNEVALGIPVPKfWARLFMGR 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45550169  181 VLPRRIVERALNQGKLFASQEALDVGLVDEIACSK---EEALSKCAAFIatfdKTNPVARCLTKRMCRE 246
Cdd:PLN03214 163 VIDRKVAESLLLRGRLVRPAEAKQLGLIDEVVPAAalmEAAASAMERAL----KLPSAARAATKALLRE 227
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
36-211 3.61e-17

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 81.45  E-value: 3.61e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   36 TIEVDDRS-GIATLSMNLP-PVNTLTMELMHDLIDSINQIESNKS-RGLILTSSNDkVFSAGLDLNEML---NPDVERL- 108
Cdd:PRK11730   7 TLQVDWLEdGIAELVFDAPgSVNKLDRATLASLGEALDALEAQSDlKGLLLTSAKD-AFIVGADITEFLslfAAPEEELs 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  109 -------RLFwTRFQDLwlalhlcGLPTAAAINGHSPAAGCVLATACEYRVMLPNLFIGIHATRFSfviskwMMNSY-QS 180
Cdd:PRK11730  86 qwlhfanSIF-NRLEDL-------PVPTVAAINGYALGGGCECVLATDYRVASPDARIGLPETKLG------IMPGFgGT 151

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 45550169  181 V-LPRRI-VERALN---QGKLFASQEALDVGLVDEI 211
Cdd:PRK11730 152 VrLPRLIgADNALEwiaAGKDVRAEDALKVGAVDAV 187
PRK07509 PRK07509
crotonase/enoyl-CoA hydratase family protein;
31-254 7.07e-17

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181008 [Multi-domain]  Cd Length: 262  Bit Score: 78.38  E-value: 7.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   31 TSKLTTIEVDDrsGIATLSMNLP-PVNTLTMELMHDLIDSINQIESNKS-RGLILtSSNDKVFSAGLDLNEMLNPDVERL 108
Cdd:PRK07509   1 MMDRVSVTIED--GIADVRLNRPdKMNALDFAMFEELIATIKRLKKDRGiRAVIL-SGEGGAFCAGLDVKSVASSPGNAV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  109 RLFWTR-------FQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNlfigihaTRFSFVISKW-----M-- 174
Cdd:PRK07509  78 KLLFKRlpgnanlAQRVSLGWRRLPVPVIAALEGVCFGGGLQIALGADIRIAAPD-------TKLSIMEAKWglvpdMag 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  175 MNSYQSVLPRRIVERALNQGKLFASQEALDVGLVDEIACSKEEALSKCAAFIAtfdKTNPVARCLTKRMCR---EPDVRE 251
Cdd:PRK07509 151 TVSLRGLVRKDVARELTYTARVFSAEEALELGLVTHVSDDPLAAALALAREIA---QRSPDAIAAAKRLINrswTASVRA 227


                 ...
gi 45550169  252 LLQ 254
Cdd:PRK07509 228 LLA 230
PRK05980 PRK05980
crotonase/enoyl-CoA hydratase family protein;
36-211 7.85e-15

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180335 [Multi-domain]  Cd Length: 260  Bit Score: 72.48  E-value: 7.85e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   36 TIEVDDRSGIATLSMNLPP-VNTLTMELMHDLIDSINQIESNKS-RGLILTSSNDKVFSAGLDLNEmLNPDVER-----L 108
Cdd:PRK05980   4 TVLIEIRDGIALLTLNRPEkLNALNYALIDRLLARLDAIEVDESvRAVILTGAGDRAFSAGADIHE-FSASVAAgadvaL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  109 RLFWTRFQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEyrvmlpnlfIGIHATRFSFV---ISKWMMNSYQSV--LP 183
Cdd:PRK05980  83 RDFVRRGQAMTARLEAFPKPVIAAVNGLAFGGGCEITEAVH---------LAIASERALFAkpeIRLGMPPTFGGTqrLP 153

                        170       180       190
                 ....*....|....*....|....*....|..
gi 45550169  184 RRI-VERALN---QGKLFASQEALDVGLVDEI 211
Cdd:PRK05980 154 RLAgRKRALElllTGDAFSAERALEIGLVNAV 185
PRK07659 PRK07659
enoyl-CoA hydratase; Provisional
 31-287 1.44e-14

enoyl-CoA hydratase; Provisional


Pssm-ID: 236073 [Multi-domain]  Cd Length: 260  Bit Score: 71.60  E-value: 1.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   31 TSKLTTIEVDDRSGIATLSMNLPPV-NTLTMELMHDLIDSINQIESNKSRGLILtSSNDKVFSAGLDLNEMLNPDVErlr 109
Cdd:PRK07659   2 TSKMESVVVKYEGRVATIMLNRPEAlNALDEPMLKELLQALKEVAESSAHIVVL-RGNGRGFSAGGDIKMMLSSNDE--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  110 lfwTRFQDLW-----LALHLCGLP--TAAAIngHSPAAGC--VLATACEYRVMLPNL-----FIGI--------HatrFs 167
Cdd:PRK07659  78 ---SKFDGVMntiseIVVTLYTMPklTISAI--HGPAAGLglSIALTADYVIADISAklamnFIGIglipdgggH---F- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  168 fviskwmmnsyqsVLPRRIVERALNQ----GKLFASQEALDVGLVDEIAcsKEEALSKCAAFIATFDKTNPVARCLTKRM 243
Cdd:PRK07659 149 -------------FLQKRVGENKAKQiiweGKKLSATEALDLGLIDEVI--GGDFQTAAKQKISEWLQKPLKAMIETKQI 213

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 45550169  244 CREPDVRELLQ----DRAAD--LKECVDYvttplfQEGLCAHLEglkKRK 287
Cdd:PRK07659 214 YCELNRSQLEQvlqlEKRAQyaMRQTADH------KEGIRAFLE---KRL 254
PRK06213 PRK06213
crotonase/enoyl-CoA hydratase family protein;
32-241 2.92e-14

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 235744  Cd Length: 229  Bit Score: 70.39  E-value: 2.92e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   32 SKLTTIEVDDrsGIATLSMNLPPVNTLTMELMHDLIDSINQIESNksRGLILTSSNDKVFSAGLDLNEMLNPDVERLRLF 111
Cdd:PRK06213   2 SELVSYTLED--GVATITLDDGKVNALSPAMIDALNAALDQAEDD--RAVVVITGQPGIFSGGFDLKVMTSGAQAAIALL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  112 wTRFQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNLF-IGIHATRFSFVISKWMMNSYQSVLPRRIVERA 190
Cdd:PRK06213  78 -TAGSTLARRLLSHPKPVIVACTGHAIAKGAFLLLSADYRIGVHGPFkIGLNEVAIGMTMPHAAIELARDRLTPSAFQRA 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 45550169  191 LNQGKLFASQEALDVGLVDEIAcSKEEALSKCAAFIATFDKTNPVARCLTK 241
Cdd:PRK06213 157 VINAEMFDPEEAVAAGFLDEVV-PPEQLLARAQAAARELAGLNMGAHAATK 206
PRK08260 PRK08260
enoyl-CoA hydratase; Provisional
 35-243 9.11e-14

enoyl-CoA hydratase; Provisional


Pssm-ID: 236206 [Multi-domain]  Cd Length: 296  Bit Score: 70.04  E-value: 9.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   35 TTIEVDDRSGIATLSMNLPP-VNTLTMELMHDLIDSINQIESNKS-RGLILTSSNdKVFSAGLDL---------NEMLNP 103
Cdd:PRK08260   4 ETIRYDVADGIATITLNRPDkLNAFTVTMARELIEAFDAADADDAvRAVIVTGAG-RAFCAGADLsaggntfdlDAPRTP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  104 DVERLRL----FWTRFQD----LWLALHLCGLPTAAAINGhsPAAGcVLATaceyrVMLP-NLFIGIHATRFSFVI---- 170
Cdd:PRK08260  83 VEADEEDradpSDDGVRDgggrVTLRIFDSLKPVIAAVNG--PAVG-VGAT-----MTLAmDIRLASTAARFGFVFgrrg 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  171 ------SKWMmnsyqsvLPRrIV--ERALN---QGKLFASQEALDVGLVDEIAcSKEEALSKCAAFIATF-DKTNPVARC 238
Cdd:PRK08260 155 ivpeaaSSWF-------LPR-LVglQTALEwvySGRVFDAQEALDGGLVRSVH-PPDELLPAARALAREIaDNTSPVSVA 225


                 ....*
gi 45550169  239 LTKRM 243
Cdd:PRK08260 226 LTRQM 230
PRK07657 PRK07657
enoyl-CoA hydratase; Provisional
 43-242 9.97e-14

enoyl-CoA hydratase; Provisional


Pssm-ID: 181069 [Multi-domain]  Cd Length: 260  Bit Score: 69.38  E-value: 9.97e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   43 SGIATLSMNLP-PVNTLTMELMHDLIDSINQIESNKS-RGLILTSSNDKVFSAGLDLNEMLNPDVERLRLFWTRFQDLWL 120
Cdd:PRK07657  12 PHVVKITLNRPrAANALSLALLEELQNILTQINEEANvRVVILTGAGEKAFCAGADLKERAGMNEEQVRHAVSLIRTTME 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  121 ALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNLFIGIHATRFSFVISKwmmNSYQSvLPRRI-VERA---LNQGKL 196
Cdd:PRK07657  92 MVEQLPQPVIAAINGIALGGGLELALACDFRIAAESASLGLTETTLAIIPGA---GGTQR-LPRLIgVGRAkelIYTGRR 167

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 45550169  197 FASQEALDVGLVdEIACSKEEALSKCAAFIATFDKTNPVARCLTKR 242
Cdd:PRK07657 168 ISAQEAKEIGLV-EFVVPAHLLEEKAIEIAEKIASNGPIAVRQAKE 212
PRK09076 PRK09076
enoyl-CoA hydratase; Provisional
 35-152 1.15e-13

enoyl-CoA hydratase; Provisional


Pssm-ID: 236373 [Multi-domain]  Cd Length: 258  Bit Score: 69.18  E-value: 1.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   35 TTIEVDDRSGIATLSMNLPPVNTLTMELMHDLIDSINQIESNKS-RGLILTSSNDKVFSAGLDLNEMLNPDVERLRLFWT 113
Cdd:PRK09076   3 IELDLEIDGHVAILTLNNPPANTWTADSLQALKQLVLELNADKDvYALVITGDGEKFFSAGADLNLFADGDKAVAREMAR 82

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 45550169  114 RFQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRV 152
Cdd:PRK09076  83 RFGEAFEALSAFRGVSIAAINGYAMGGGLECALACDIRI 121
PRK05995 PRK05995
enoyl-CoA hydratase; Provisional
 35-287 3.25e-13

enoyl-CoA hydratase; Provisional


Pssm-ID: 235664 [Multi-domain]  Cd Length: 262  Bit Score: 68.03  E-value: 3.25e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   35 TTIEVDDRSGIATLSMNLPPV-NTLTMELMHDLIDSINQIESNKS-RGLILTSsNDKVFSAGLDLNEM---LNPDVERLR 109
Cdd:PRK05995   4 ETLEIEQRGQVATVTLNRPDVrNAFNETVIAELTAAFRALDADDSvRAVVLAG-AGKAFCAGADLNWMkkmAGYSDDENR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  110 LFWTRFQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVM-------LPNLFIG-IHATRFSFVISKwmmnsyqsv 181
Cdd:PRK05995  83 ADARRLADMLRAIYRCPKPVIARVHGDAYAGGMGLVAACDIAVAadhavfcLSEVRLGlIPATISPYVIRA--------- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  182 LPRRIVERALNQGKLFASQEALDVGLVDEiACSKEEALSKCAAFIATFDKTNP--VARCltKRMCREPDVRELLQDRAAD 259
Cdd:PRK05995 154 MGERAARRYFLTAERFDAAEALRLGLVHE-VVPAEALDAKVDELLAALVANSPqaVRAG--KRLVRDVAGRPIDAALIAD 230

                        250       260
                 ....*....|....*....|....*....
gi 45550169  260 LKECV-DYVTTPLFQEGLCAHLEglkKRK 287
Cdd:PRK05995 231 TASRIaLIRATEEAREGVAAFLE---KRK 256
PRK07854 PRK07854
enoyl-CoA hydratase; Provisional
 37-212 4.50e-13

enoyl-CoA hydratase; Provisional


Pssm-ID: 236115 [Multi-domain]  Cd Length: 243  Bit Score: 67.36  E-value: 4.50e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   37 IEVDDRSGIATLSMNLPPV-NTLTMELMHDLIDSINQIESNKSRGLILTSSNdKVFSAGLDLNEMLNPDVerlrlFWTRF 115
Cdd:PRK07854   2 IGVTRDGQVLTIELQRPERrNALNAELCEELREAVRKAVDESARAIVLTGQG-TVFCAGADLSGDVYADD-----FPDAL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  116 QDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNLFIGIHATRFSFVISKWMMNSYQSVL----PRRIVeraL 191
Cdd:PRK07854  76 IEMLHAIDAAPVPVIAAINGPAIGAGLQLAMACDLRVVAPEAYFQFPVAKYGIALDNWTIRRLSSLVgggrARAML---L 152

                        170       180
                 ....*....|....*....|.
gi 45550169  192 NQGKLFASQeALDVGLVDEIA 212
Cdd:PRK07854 153 GAEKLTAEQ-ALATGMANRIG 172
PRK06495 PRK06495
enoyl-CoA hydratase/isomerase family protein;
35-149 4.61e-13

enoyl-CoA hydratase/isomerase family protein;


Pssm-ID: 168580 [Multi-domain]  Cd Length: 257  Bit Score: 67.41  E-value: 4.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   35 TTIEVDDRSGIATLSMNLPPVNTLTMELMHDLIDSINQI-ESNKSRGLILTSSNdKVFSAGLDLNEMLNPDVE----RLR 109
Cdd:PRK06495   4 SQLKLEVSDHVAVVTLDNPPVNALSRELRDELIAVFDEIsERPDVRVVVLTGAG-KVFCAGADLKGRPDVIKGpgdlRAH 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 45550169  110 LFWTRfqDLWLALHLCGLPTAAAINGHSPAAGCVLATACE 149
Cdd:PRK06495  83 NRRTR--ECFHAIRECAKPVIAAVNGPALGAGLGLVASCD 120
PRK05809 PRK05809
short-chain-enoyl-CoA hydratase;
34-281 8.47e-13

short-chain-enoyl-CoA hydratase;


Pssm-ID: 180270 [Multi-domain]  Cd Length: 260  Bit Score: 66.69  E-value: 8.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   34 LTTIEVDDRSGIATLSMNLP-PVNTLTMELMHDLIDSINQIESNKS-RGLILTSSNDKVFSAGLDLNEMLNPDVERLRLF 111
Cdd:PRK05809   3 LKNVILEKEGHIAVVTINRPkALNALNSETLKELDTVLDDIENDDNvYAVILTGAGEKAFVAGADISEMKDLNEEEGRKF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  112 WTRFQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNLFIGihATRFSFVISKWMMNSYQsvLPRRI----V 187
Cdd:PRK05809  83 GLLGNKVFRKLENLDKPVIAAINGFALGGGCELSMACDIRIASEKAKFG--QPEVGLGITPGFGGTQR--LARIVgpgkA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  188 ERALNQGKLFASQEALDVGLVDEIAcSKEEALSKCAAFIATFDKTNPVARCLTKRMCR---EPDVRELLQDRAADLKECv 264
Cdd:PRK05809 159 KELIYTGDMINAEEALRIGLVNKVV-EPEKLMEEAKALANKIAANAPIAVKLCKDAINrgmQVDIDTAVAIEAEDFGEC- 236

                        250
                 ....*....|....*..
gi 45550169  265 dyVTTPLFQEGLCAHLE 281
Cdd:PRK05809 237 --FSTEDQTEGMTAFVE 251
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
30-211 1.17e-12

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 68.00  E-value: 1.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   30 ATSKLTTIEVDDrSGIATLSMNLP--PVNTLTMELMHDLIDSINQIESNKS-RGLILTSSNDKVFSAGLDLNeMLN--PD 104
Cdd:PRK11154   2 EMASAFTLNVRE-DNIAVITIDVPgeKMNTLKAEFAEQVRAILKQLREDKElKGVVFISGKPDNFIAGADIN-MLAacKT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  105 VERLRLFWTRFQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVM---------LPN----LFIGIHAT-Rfsfvi 170
Cdd:PRK11154  80 AQEAEALARQGQQLFAEIEALPIPVVAAIHGACLGGGLELALACHYRVCtddpktvlgLPEvqlgLLPGSGGTqR----- 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 45550169  171 skwmmnsyqsvLPRRI-VERALN---QGKLFASQEALDVGLVDEI 211
Cdd:PRK11154 155 -----------LPRLIgVSTALDmilTGKQLRAKQALKLGLVDDV 188
PRK06144 PRK06144
enoyl-CoA hydratase; Provisional
 42-287 1.27e-12

enoyl-CoA hydratase; Provisional


Pssm-ID: 180424 [Multi-domain]  Cd Length: 262  Bit Score: 66.17  E-value: 1.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   42 RSGIATLSMNLPPV-NTLTMELMHDLIDSINQIESNKS-RGLILTSSNDKVFSAGLDLNEMLNPDVERLRLFWTRFQDLW 119
Cdd:PRK06144  15 RGGIARITFNRPAArNAMTWAMYEGLAEICEAIAADPSiRAVVLRGAGDKAFVAGTDIAQFRAFSTAEDAVAYERRIDRV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  120 L-ALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPnlfigihATRFSFVISKWM-----MNSYQ---SVLPRRIVERA 190
Cdd:PRK06144  95 LgALEQLRVPTIAAIAGACVGGGAAIAAACDLRIATP-------SARFGFPIARTLgnclsMSNLArlvALLGAARVKDM 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  191 LNQGKLFASQEALDVGLVDEIaCSKEEALSKCAAFIATFDKTNPvarcLTKRMCREPdVRELlqdRAADLKECVDYV--- 267
Cdd:PRK06144 168 LFTARLLEAEEALAAGLVNEV-VEDAALDARADALAELLAAHAP----LTLRATKEA-LRRL---RREGLPDGDDLIrmc 238

                        250       260
                 ....*....|....*....|.
gi 45550169  268 -TTPLFQEGLCAHLEglkKRK 287
Cdd:PRK06144 239 yMSEDFREGVEAFLE---KRP 256
PRK06688 PRK06688
enoyl-CoA hydratase; Provisional
 35-287 4.81e-12

enoyl-CoA hydratase; Provisional


Pssm-ID: 235852 [Multi-domain]  Cd Length: 259  Bit Score: 64.50  E-value: 4.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   35 TTIEVDDRSGIATLSMNLP-PVNTLTMELMHDLIDSINQIESNKS-RGLILTSSnDKVFSAGLDLNEMLN----PDVERL 108
Cdd:PRK06688   5 TDLLVELEDGVLTITINRPdKKNALTAAMYQALADALEAAATDPAvRVVVLTGA-GRAFSAGGDIKDFPKappkPPDELA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  109 RLFwtrfqDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRV-------MLPNLFIGihatrfsfviskwMMNSYQS- 180
Cdd:PRK06688  84 PVN-----RFLRAIAALPKPVVAAVNGPAVGVGVSLALACDLVYasesakfSLPFAKLG-------------LCPDAGGs 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  181 -VLPRRIVE----RALNQGKLFASQEALDVGLVDEIAcSKEEALSKCAAFIATFDKTNPVARCLTKRMCRE---PDVREL 252
Cdd:PRK06688 146 aLLPRLIGRaraaEMLLLGEPLSAEEALRIGLVNRVV-PAAELDAEADAQAAKLAAGPASALRYTKRAINAatlTELEEA 224

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 45550169  253 LQDRAADLKECVDyvtTPLFQEGLCAHLEglkKRK 287
Cdd:PRK06688 225 LAREAAGFGRLLR---TPDFREGATAFIE---KRK 253
PRK05870 PRK05870
enoyl-CoA hydratase; Provisional
 36-212 6.14e-12

enoyl-CoA hydratase; Provisional


Pssm-ID: 180298  Cd Length: 249  Bit Score: 63.98  E-value: 6.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   36 TIEVDDRSGIATLSMNLPP-VNTLTMELMHDLIDSINQIESNKS-RGLILTSSNdKVFSAGLDLNEM----LNPDVERLR 109
Cdd:PRK05870   4 PVLLDVDDGVALITVNDPDrRNAVTAEMSAQLRAAVAAAEADPDvHALVVTGAG-KAFCAGADLTALgaapGRPAEDGLR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  110 lfwtRFQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPN-LF------IGIH----ATrfsfviskWMMNsy 178
Cdd:PRK05870  83 ----RIYDGFLAVASCPLPTIAAVNGAAVGAGLNLALAADVRIAGPKaLFdarfqkLGLHpgggAT--------WMLQ-- 148

                        170       180       190
                 ....*....|....*....|....*....|....
gi 45550169  179 QSVLPRRiVERALNQGKLFASQEALDVGLVDEIA 212
Cdd:PRK05870 149 RAVGPQV-ARAALLFGMRFDAEAAVRHGLALMVA 181
PLN02664 PLN02664
enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase
 34-269 1.19e-11

enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase


Pssm-ID: 178269 [Multi-domain]  Cd Length: 275  Bit Score: 63.77  E-value: 1.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   34 LTTIEVDDRSGIATLSMNLPP-VNTLTMELMHDLIDSINQIESNKSRGLILTSSNDKVFSAGLDLNEM-------LNPDV 105
Cdd:PLN02664   7 LEIIQKSPNSSVFHLNLNRPSqRNALSLDFFTEFPKALSSLDQNPNVSVIILSGAGDHFCSGIDLKTLnsiseqsSSGDR 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  106 ----ERLRLFWTRFQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNLFIGIHATRFSFVISKWMMNSYQSV 181
Cdd:PLN02664  87 grsgERLRRKIKFLQDAITAIEQCRKPVIAAIHGACIGGGVDIVTACDIRYCSEDAFFSVKEVDLAITADLGTLQRLPSI 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  182 LP-RRIVERALNqGKLFASQEALDVGLVDEIACSKE---EALSKCAAFIATfdkTNPVARCLTKRMcrepdvreLLQDRA 257
Cdd:PLN02664 167 VGyGNAMELALT-GRRFSGSEAKELGLVSRVFGSKEdldEGVRLIAEGIAA---KSPLAVTGTKAV--------LLRSRE 234

                        250
                 ....*....|..
gi 45550169  258 ADLKECVDYVTT 269
Cdd:PLN02664 235 LSVEQGLDYVAT 246
PLN02267 PLN02267
enoyl-CoA hydratase/isomerase family protein
 57-218 1.28e-11

enoyl-CoA hydratase/isomerase family protein


Pssm-ID: 215151  Cd Length: 239  Bit Score: 63.19  E-value: 1.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   57 TLTME----LMHDLIDSI----NQIESNKSRGLIL-TSSNDKVFSAGLDLN--EMLNPDVERLRLFWTRFQDLWLALHLC 125
Cdd:PLN02267  14 TLTGDgehrLNPTLIDSIrsalRQVKSQATPGSVLiTTAEGKFFSNGFDLAwaQAAGSAPSRLHLMVAKLRPLVADLISL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  126 GLPTAAAINGHSPAAGCVLATACEYRVM--------LPNLFIGIhatrfsfVISKWMMNSYQSVLPRRIVER--ALNQGK 195
Cdd:PLN02267  94 PMPTIAAVTGHASAAGFILALSHDYVLMrkdrgvlyMSEVDIGL-------PLPDYFMALLRAKIGSPAARRdvLLRAAK 166

                        170       180
                 ....*....|....*....|...
gi 45550169  196 LFAsQEALDVGLVDEIACSKEEA 218
Cdd:PLN02267 167 LTA-EEAVEMGIVDSAHDSAEET 188
PRK08138 PRK08138
enoyl-CoA hydratase; Provisional
 44-236 1.52e-11

enoyl-CoA hydratase; Provisional


Pssm-ID: 236162 [Multi-domain]  Cd Length: 261  Bit Score: 63.15  E-value: 1.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   44 GIATLSMNLPPV-NTLTMELMHDLIDSINQIESNKSRGLILTSSNDKVFSAGLDLNEMLnpDVERLRLFWTRFQDLWLAL 122
Cdd:PRK08138  17 GVALLRLNRPEArNALNMEVRQQLAEHFTELSEDPDIRAIVLTGGEKVFAAGADIKEFA--TAGAIEMYLRHTERYWEAI 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  123 HLCGLPTAAAINGHSPAAGCVLATACEYRVM-------LPNLFIGIH-----ATRFSFVISKwmmnsYQSVlprriveRA 190
Cdd:PRK08138  95 AQCPKPVIAAVNGYALGGGCELAMHADIIVAgesasfgQPEIKVGLMpgaggTQRLVRAVGK-----FKAM-------RM 162

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 45550169  191 LNQGKLFASQEALDVGLVDEIaCSKEEALSKCAAFIATFDKTNPVA 236
Cdd:PRK08138 163 ALTGCMVPAPEALAIGLVSEV-VEDEQTLPRALELAREIARMPPLA 207
PRK07658 PRK07658
enoyl-CoA hydratase; Provisional
 33-287 3.38e-11

enoyl-CoA hydratase; Provisional


Pssm-ID: 181070 [Multi-domain]  Cd Length: 257  Bit Score: 61.96  E-value: 3.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   33 KLTTIEVDDrsGIATLSMNLPPVNTLTMELMHDLIDSINQIESNKSRGLILTSSNDKVFSAGLDLNEMLN-PDVERLRLF 111
Cdd:PRK07658   2 KFLSVRVED--HVAVITLNHPPANALSSQVLHELSELLDQVEKDDNVRVVVIHGEGRFFSAGADIKEFTSvTEAEQATEL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  112 WTRFQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVM-------LPNLFIGI-----HATRfsfviskwmmnsyq 179
Cdd:PRK07658  80 AQLGQVTFERVEKFSKPVIAAIHGAALGGGLELAMSCHIRFAtesaklgLPELNLGLipgfaGTQR-------------- 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  180 svLPRRI-VERALNQ---GKLFASQEALDVGLVDEiACSKEEALSKCAAFIATFDKTNPvarcLTKRMcrepdVRELLQ- 254
Cdd:PRK07658 146 --LPRYVgKAKALEMmltSEPITGAEALKWGLVNG-VFPEETLLDDAKKLAKKIAGKSP----ATTRA-----VLELLQt 213

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 45550169  255 DRAADLKECVDyVTTPLF---------QEGLCAHLEglkKRK 287
Cdd:PRK07658 214 TKSSSYYEGVK-REAKIFgevftsedaKEGVQAFLE---KRK 251
PRK08139 PRK08139
enoyl-CoA hydratase; Validated
 40-227 3.63e-11

enoyl-CoA hydratase; Validated


Pssm-ID: 181249  Cd Length: 266  Bit Score: 62.27  E-value: 3.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   40 DDRSGIATLSMNLPP-VNTLTMELMHDLIDSINQIESNKSRGLILTSSNDKVFSAGLDLNEM-LNPDVERLRLFWTRFQD 117
Cdd:PRK08139  16 EDRDGVATLTLNRPQaFNALSEAMLAALQAALDAIAADPSVRVVVLAAAGKAFCAGHDLKEMrAARGLAYFRALFARCSR 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  118 LWLALHLCGLPTAAAINGHSPAAGCVLATACEyrvmlpnLFIGIHATRFS--------FVISKwmMNSYQSVLPRRIVER 189
Cdd:PRK08139  96 VMQAIVALPQPVIARVHGIATAAGCQLVASCD-------LAVAADTARFAvpgvniglFCSTP--MVALSRNVPRKQAME 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 45550169  190 ALNQGKLFASQEALDVGLVDEI--ACSKEEALSKCAAFIA 227
Cdd:PRK08139 167 MLLTGEFIDAATAREWGLVNRVvpADALDAAVARLAAVIA 206
PRK06210 PRK06210
enoyl-CoA hydratase; Provisional
 36-281 5.88e-11

enoyl-CoA hydratase; Provisional


Pssm-ID: 180472  Cd Length: 272  Bit Score: 61.64  E-value: 5.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   36 TIEVDDrSGIATLSMNLPP-VNTLTMELMHDLIDSINQIESNKSRGLILTSSNDKVFSAGLDLNEM--LNPDVERlRLFW 112
Cdd:PRK06210   8 LYEVAD-SGVAVITLNRPDrLNAWTPVMEAEVYAAMDRAEADPAVRVIVLTGAGRGFCAGADMGELqtIDPSDGR-RDTD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  113 TR---------FQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNlfiGIHATRFS-------FVISkWMmn 176
Cdd:PRK06210  86 VRpfvgnrrpdYQTRYHFLTALRKPVIAAINGACAGIGLTHALMCDVRFAADG---AKFTTAFArrgliaeHGIS-WI-- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  177 syqsvLPRrIVERA-----LNQGKLFASQEALDVGLVDEIaCSKEEALSKCAAFIATF-DKTNPVARCLTKRMCREPDVR 250
Cdd:PRK06210 160 -----LPR-LVGHAnaldlLLSARTFYAEEALRLGLVNRV-VPPDELMERTLAYAEDLaRNVSPASMAVIKRQLYEDAFQ 232

                        250       260       270
                 ....*....|....*....|....*....|.
gi 45550169  251 ELLQDRAADLKECVDYVTTPLFQEGLCAHLE 281
Cdd:PRK06210 233 TLAEATARANREMHESLQRPDFIEGVASFLE 263
PRK08258 PRK08258
enoyl-CoA hydratase family protein;
38-265 7.06e-11

enoyl-CoA hydratase family protein;


Pssm-ID: 181329  Cd Length: 277  Bit Score: 61.52  E-value: 7.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   38 EVDDrsGIATLSMNLPP-VNTLTMELMHDLIDSINQIESNKS-RGLILTSSNDKvFSAGLDLNEMLNP----DVERLRLF 111
Cdd:PRK08258  22 EVDD--GVATITLNRPErKNPLTFESYAELRDLFRELVYADDvKAVVLTGAGGN-FCSGGDVHEIIGPltkmDMPELLAF 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  112 wTRFQ-DLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRvmlpnlfIGIHATRFSFVISKW------MMNSYqsVLPR 184
Cdd:PRK08258  99 -TRMTgDLVKAMRACPQPIIAAVDGVCAGAGAILAMASDLR-------LGTPSAKTAFLFTRVglagadMGACA--LLPR 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  185 RIVE-RA---LNQGKLFASQEALDVGLVDEIaCSKEEALSKCAAFIATFDKTNPVARCLTKRMcrepdvreLLQDRAADL 260
Cdd:PRK08258 169 IIGQgRAselLYTGRSMSAEEGERWGFFNRL-VEPEELLAEAQALARRLAAGPTFAHGMTKTM--------LHQEWDMGL 239


                 ....*
gi 45550169  261 KECVD 265
Cdd:PRK08258 240 EEAIE 244
PRK09674 PRK09674
enoyl-CoA hydratase-isomerase; Provisional
 44-287 1.23e-10

enoyl-CoA hydratase-isomerase; Provisional


Pssm-ID: 182026 [Multi-domain]  Cd Length: 255  Bit Score: 60.55  E-value: 1.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   44 GIATLSMNLPPV-NTLTMELMHDLIDSINQIESNKSRGLILTSSNDKVFSAGLDLNEMLNPDVERLrLFWTRFQdLWLAL 122
Cdd:PRK09674  11 RVLLLTLNRPEArNALNNALLTQLVNELEAAATDTSIGVCVITGNARFFAAGADLNEMAEKDLAAT-LNDPRPQ-LWQRL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  123 HLCGLPTAAAINGHSPAAGCVLATACEY-------RVMLPNLFIGI-----HATRFSFVISKWMMNsyQSVLprrivera 190
Cdd:PRK09674  89 QAFNKPLIAAVNGYALGAGCELALLCDIviagenaRFGLPEITLGImpgagGTQRLIRSVGKSLAS--QMVL-------- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  191 lnQGKLFASQEALDVGLVDEIaCSKEEALSKCAAFIATFDKTNPVARCLTKRMCREPDVRELLQDRAADLKECVDYVTTP 270
Cdd:PRK09674 159 --TGESITAQQAQQAGLVSEV-FPPELTLERALQLASKIARHSPLALRAAKQALRQSQEVDLQAGLAQERQLFTLLAATE 235

                        250
                 ....*....|....*..
gi 45550169  271 LFQEGLCAHLEglkKRK 287
Cdd:PRK09674 236 DRHEGISAFLE---KRT 249
PLN02600 PLN02600
enoyl-CoA hydratase
 43-242 2.45e-10

enoyl-CoA hydratase


Pssm-ID: 178210 [Multi-domain]  Cd Length: 251  Bit Score: 59.43  E-value: 2.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   43 SGIATLSMNLPPV-NTLTMELMHDLIDSINQIESNKS-RGLILTSSNDKVFSAGLDLNEMLNPDVERLRLFWTRFQDLWL 120
Cdd:PLN02600   3 SGIVELRLDRPEAkNAIGKEMLRGLRSAFEKIQADASaRVVMLRSSVPGVFCAGADLKERRKMSPSEVQKFVNSLRSTFS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  121 ALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNLFIGIHATRFSFVISKWMMNSYQSVLPRRIVERALNQGKLFASQ 200
Cdd:PLN02600  83 SLEALSIPTIAVVEGAALGGGLELALSCDLRICGEEAVFGLPETGLAIIPGAGGTQRLPRLVGRSRAKELIFTGRRIGAR 162

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 45550169  201 EALDVGLVdEIACSKEEALSKCAAFIATFDKTNPVARCLTKR 242
Cdd:PLN02600 163 EAASMGLV-NYCVPAGEAYEKALELAQEINQKGPLAIKMAKK 203
PRK06072 PRK06072
enoyl-CoA hydratase; Provisional
 37-152 9.09e-10

enoyl-CoA hydratase; Provisional


Pssm-ID: 168377 [Multi-domain]  Cd Length: 248  Bit Score: 57.87  E-value: 9.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   37 IEVDDRSGIATLSMNLP-PVNTLTMELMHDLIDSINQIESN-KSRGLILTSSNdKVFSAGLDLNEMLNPDVERLRlfwTR 114
Cdd:PRK06072   2 IKVESREGYAIVTMSRPdKLNALNLEMRNEFISKLKQINADpKIRVVIVTGEG-RAFCVGADLSEFAPDFAIDLR---ET 77

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 45550169  115 FQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRV 152
Cdd:PRK06072  78 FYPIIREIRFSDKIYISAINGVTAGACIGIALSTDFKF 115
PRK09245 PRK09245
crotonase/enoyl-CoA hydratase family protein;
37-246 1.38e-09

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181723  Cd Length: 266  Bit Score: 57.29  E-value: 1.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   37 IEVDDRSGIATLSMNLPPV-NTLT-MELMHDLIDSINQIESNKS-RGLILTSSnDKVFSAGLDLNEM--------LNPDV 105
Cdd:PRK09245   5 LLVERDGHIVTLTMNRPETrNALSdNDAVDALVAACAAINADRSvRAVILTGA-GTAFSSGGNVKDMrarvgafgGSPAD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  106 ERLRlFWTRFQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRvmlpnlfIGIHATRF--SFVI--------SKWMm 175
Cdd:PRK09245  84 IRQG-YRHGIQRIPLALYNLEVPVIAAVNGPAIGAGCDLACMCDIR-------IASETARFaeSFVKlglipgdgGAWL- 154

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45550169  176 nsyqsvLPR-----RIVERALNqGKLFASQEALDVGLVDEIAcsKEEALSKCAAFIATFDKTNP--VARcLTKRMCRE 246
Cdd:PRK09245 155 ------LPRiigmaRAAEMAFT-GDAIDAATALEWGLVSRVV--PADQLLPAARALAERIAANPphALR-LTKRLLRE 222
PLN02888 PLN02888
enoyl-CoA hydratase
 41-221 5.97e-09

enoyl-CoA hydratase


Pssm-ID: 215480  Cd Length: 265  Bit Score: 55.53  E-value: 5.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   41 DRSGIATLSMNLP-PVNTLTMELMHDLIDSINQIESNKS-RGLILTSSNdKVFSAGLDLN---EMLNPDVErlrlfwTRF 115
Cdd:PLN02888  16 SRNGIATITINRPkALNALTRPMMVELAAAFKRLDEDDSvKVIILTGSG-RAFCSGVDLTaaeEVFKGDVK------DVE 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  116 QDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNL-FIGIHAtRFSFVISkWMMNSYqsvLPRRI-VERA--- 190
Cdd:PLN02888  89 TDPVAQMERCRKPIIGAINGFAITAGFEIALACDILVASRGAkFIDTHA-KFGIFPS-WGLSQK---LSRIIgANRArev 163

                        170       180       190
                 ....*....|....*....|....*....|..
gi 45550169  191 -LNQGKLFASQeALDVGLVDEIAcSKEEALSK 221
Cdd:PLN02888 164 sLTAMPLTAET-AERWGLVNHVV-EESELLKK 193
PRK05869 PRK05869
enoyl-CoA hydratase; Validated
 40-212 8.76e-09

enoyl-CoA hydratase; Validated


Pssm-ID: 235632 [Multi-domain]  Cd Length: 222  Bit Score: 54.46  E-value: 8.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   40 DDRSGIATLSMNLPPVNTLTMELMHDLIDSINQIESNKSRGLILTSSNDKVFSAGLDLNEM--LNPD----VERLRlfwt 113
Cdd:PRK05869  13 SQDAGLATLLLSRPPTNALTRQVYREIVAAANELGRRDDVAAVILYGGHEIFSAGDDMPELrtLSAQeadtAARVR---- 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  114 rfQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNLFIGIHATRFSFVISKWMMNSYQSVLPRRIVERALNQ 193
Cdd:PRK05869  89 --QQAVDAVAAIPKPTVAAITGYALGAGLTLALAADWRVSGDNVKFGATEILAGLAPSGDGMARLTRAAGPSRAKELVFS 166

                        170
                 ....*....|....*....
gi 45550169  194 GKLFASQEALDVGLVDEIA 212
Cdd:PRK05869 167 GRFFDAEEALALGLIDEMV 185
PRK07827 PRK07827
enoyl-CoA hydratase family protein;
31-281 1.54e-08

enoyl-CoA hydratase family protein;


Pssm-ID: 236109 [Multi-domain]  Cd Length: 260  Bit Score: 54.30  E-value: 1.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   31 TSKLTTIEVDDRSGIATLSMNLPP-VNTLTMELMHDLIDSINQIESNKS-RGLILTSSNdKVFSAGLDLNEMLNP--DVE 106
Cdd:PRK07827   2 TPVDTLVRYAVDGGVATLTLDSPHnRNALSARLVAQLHDGLRAAAADPAvRAVVLTHTG-GTFCAGADLSEAGGGggDPY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  107 RLRLFWTR-FQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNLFIGIHATRFS---FVISkwmmnsyQSVL 182
Cdd:PRK07827  81 DAAVARAReMTALLRAIVELPKPVIAAIDGHVRAGGFGLVGACDIVVAGPESTFALTEARIGvapAIIS-------LTLL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  183 PR---RIVERALNQGKLFASQEALDVGLVDEIACSKEEALskcAAFIATFDKTNPVARCLTKRMCREPDVRELLQDRAAD 259
Cdd:PRK07827 154 PRlspRAAARYYLTGEKFGAAEAARIGLVTAAADDVDAAV---AALLADLRRGSPQGLAESKALTTAAVLAGFDRDAEEL 230

                        250       260
                 ....*....|....*....|..
gi 45550169  260 LKECVDYVTTPLFQEGLCAHLE 281
Cdd:PRK07827 231 TEESARLFVSDEAREGMTAFLQ 252
PRK06190 PRK06190
enoyl-CoA hydratase; Provisional
 39-211 8.15e-08

enoyl-CoA hydratase; Provisional


Pssm-ID: 235733  Cd Length: 258  Bit Score: 52.28  E-value: 8.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   39 VDDRSGIATLSMNLPPV-NTLTMELMHDLIDSINQIESNKS-RGLILTSSnDKVFSAGLDLNEmLNPDVERLRLfWTRFQ 116
Cdd:PRK06190   8 VETHDRVRTLTLNRPEArNALSAALRRALFAALAEADADDDvDVVVLTGA-DPAFCAGLDLKE-LGGDGSAYGA-QDALP 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  117 DLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPN-LFIGIHAtRFSfVISKWMMNSY--QSVLPRRIVERALNq 193
Cdd:PRK06190  85 NPSPAWPAMRKPVIGAINGAAVTGGLELALACDILIASERaRFADTHA-RVG-ILPGWGLSVRlpQKVGIGRARRMSLT- 161

                        170
                 ....*....|....*...
gi 45550169  194 GKLFASQEALDVGLVDEI 211
Cdd:PRK06190 162 GDFLDAADALRAGLVTEV 179
PRK06494 PRK06494
enoyl-CoA hydratase; Provisional
 37-236 1.84e-07

enoyl-CoA hydratase; Provisional


Pssm-ID: 180591 [Multi-domain]  Cd Length: 259  Bit Score: 51.20  E-value: 1.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   37 IEVDDRSGIATLSMNLPPV-NTLTMELMHDLIDSINQIESN-KSRGLILTSSNDKVFSAGLDLNEMlnpdVERLRLFW-- 112
Cdd:PRK06494   6 STVERKGHVTIVTLNRPEVmNALHLDAHFELEEVFDDFAADpEQWVAIVTGAGDKAFSAGNDLKEQ----AAGGKRGWpe 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  113 TRFQDLwLALHLCGLPTAAAINGHSPAAGCVLATAC--------------EYRVMLPNLFIGIHAtrfsfviskwmmnsy 178
Cdd:PRK06494  82 SGFGGL-TSRFDLDKPIIAAVNGVAMGGGFELALACdlivaaenatfalpEPRVGLAALAGGLHR--------------- 145

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45550169  179 qsvLPRRI-VERALNQ---GKLFASQEALDVGLVDEIAcSKEEALSKCAAFIATFDKTNPVA 236
Cdd:PRK06494 146 ---LPRQIgLKRAMGMiltGRRVTAREGLELGFVNEVV-PAGELLAAAERWADDILACSPLS 203
PRK06127 PRK06127
enoyl-CoA hydratase; Provisional
 36-287 2.84e-07

enoyl-CoA hydratase; Provisional


Pssm-ID: 235705  Cd Length: 269  Bit Score: 50.47  E-value: 2.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   36 TIEVDDRSGIATLSMNLPP-VNTLTMELMHDLIDSINQIESNKS-RGLILTSSNDKVFSAGLDLNEM--LNPDVERLRLF 111
Cdd:PRK06127  12 KLLAEKTGGLGRITFNNPArHNAMSLDMWEALPQALAAAEDDDAiRVVVLTGAGEKAFVSGADISQFeeSRSDAEAVAAY 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  112 WTRFQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNLFIGIHATRFSFviskwmmnSYQSVLPRRIVE--- 188
Cdd:PRK06127  92 EQAVEAAQAALADYAKPTIACIRGYCIGGGMGIALACDIRIAAEDSRFGIPAARLGL--------GYGYDGVKNLVDlvg 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  189 --RALN---QGKLFASQEALDVGLVDEiACSKEEALSKCAAFIATFDKTNPVARCLTKRMcrepdVRELLQDRAA-DLKE 262
Cdd:PRK06127 164 psAAKDlfyTARRFDAAEALRIGLVHR-VTAADDLETALADYAATIAGNAPLTLRAAKRA-----IAELLKDEPErDMAA 237

                        250       260
                 ....*....|....*....|....*....
gi 45550169  263 CVDYVTTPL----FQEGLCAHLEglkKRK 287
Cdd:PRK06127 238 CQALVAACFdsedYREGRAAFME---KRK 263
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 35-152 3.58e-07

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 51.38  E-value: 3.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169    35 TTIEVDDRSGIATLSMNLP--PVNTLTMELMHDLIDSINQIESNKS-RGLILTSSNDKVFSAGLDLNeMLNP--DVERLR 109
Cdd:TIGR02441  13 THRHYEVKGDVAVVKIDSPnsKVNTLSKELFAEFKEVMNELWTNEAiKSAVLISGKPGSFVAGADIQ-MIAAckTAQEVT 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 45550169   110 LFWTRFQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRV 152
Cdd:TIGR02441  92 QLSQEGQEMFERIEKSQKPIVAAISGSCLGGGLELALACHYRI 134
PRK08140 PRK08140
enoyl-CoA hydratase; Provisional
 36-148 5.42e-07

enoyl-CoA hydratase; Provisional


Pssm-ID: 236163  Cd Length: 262  Bit Score: 49.53  E-value: 5.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   36 TIEVDDRSGIATLSMNLPP-VNTLTMELMHDLIDSINQIESNKSRGLILTSSNdKVFSAGLDLNEmLNPD---------- 104
Cdd:PRK08140   5 TILLAIEAGVATLTLNRPDkLNSFTREMHRELREALDQVEDDGARALLLTGAG-RGFCAGQDLAD-RDVTpggampdlge 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 45550169  105 -VErlrlfwTRFQDLWLALHLCGLPTAAAINGHSPAAGCVLATAC 148
Cdd:PRK08140  83 sIE------TFYNPLVRRLRALPLPVIAAVNGVAAGAGANLALAC 121
PRK06142 PRK06142
crotonase/enoyl-CoA hydratase family protein;
36-287 7.12e-07

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 235714  Cd Length: 272  Bit Score: 49.59  E-value: 7.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   36 TIEVDDrsGIATLSMNLP-PVNTLTMELMHDLIDSINQIESNKS-RGLILTSSNdKVFSAGLDL-------NEMLNPDVE 106
Cdd:PRK06142   9 TVELAD--HVAQVTLNRPgKGNAMNPAFWSELPEIFRWLDADPEvRAVVLSGSG-KHFSYGIDLpamagvfGQLGKDGLA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  107 R----LRLFWTRFQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNLFIGIHATRFSFVISkwmMNSYQSvL 182
Cdd:PRK06142  86 RprtdLRREILRLQAAINAVADCRKPVIAAVQGWCIGGGVDLISACDMRYASADAKFSVREVDLGMVAD---VGSLQR-L 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  183 PRRIVERALNQ----GKLFASQEALDVGLVDEIACSKE---EALSKCAAFIATfdkTNPVARCLTKRMcrepdvreLLQD 255
Cdd:PRK06142 162 PRIIGDGHLRElaltGRDIDAAEAEKIGLVNRVYDDADallAAAHATAREIAA---KSPLAVRGTKEV--------LDYM 230

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 45550169  256 RAADLKECVDYVTT--------PLFQEGLCAHLEglkKRK 287
Cdd:PRK06142 231 RDHRVADGLRYVATwnaamlpsKDLTEAIAAHME---KRP 267
PRK07938 PRK07938
enoyl-CoA hydratase family protein;
44-135 3.12e-06

enoyl-CoA hydratase family protein;


Pssm-ID: 181174  Cd Length: 249  Bit Score: 47.27  E-value: 3.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   44 GIATLSMNLPPVNTLTMELMHDLIDSINQIESNKS-RGLILTSSNdKVFSAGLDLNEMLN-PDVERL----RLFWTRFQd 117
Cdd:PRK07938  11 GIAEVTVDYPPVNALPSAGWFALADAITAAGADPDtRVVVLRAEG-RGFNAGVDIKELQAtPGFTALidanRGCFAAFR- 88

                         90
                 ....*....|....*...
gi 45550169  118 lwlALHLCGLPTAAAING 135
Cdd:PRK07938  89 ---AVYECAVPVIAAVHG 103
PRK07260 PRK07260
enoyl-CoA hydratase; Provisional
 35-100 3.59e-06

enoyl-CoA hydratase; Provisional


Pssm-ID: 180910 [Multi-domain]  Cd Length: 255  Bit Score: 47.04  E-value: 3.59e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45550169   35 TTIEVDDRSGIATLSMNLPPV-NTLTMELMHDLIDSINQIESNKSRGLILTSSNDKVFSAGLDLNEM 100
Cdd:PRK07260   2 EHIIYEVEDDLATLTLNRPEVsNGFNIPMCQEILEALRLAEEDPSVRFLLINANGKVFSVGGDLVEM 68
Clp_protease_like cd00394
Caseinolytic protease (ClpP) is an ATP-dependent protease; Clp protease (caseinolytic protease; ...
 121-211 6.26e-06

Caseinolytic protease (ClpP) is an ATP-dependent protease; Clp protease (caseinolytic protease; ClpP; endopeptidase Clp; Peptidase S14; ATP-dependent protease, ClpAP)-like enzymes are highly conserved serine proteases and belong to the ClpP/Crotonase superfamily. Included in this family are Clp proteases that are involved in a number of cellular processes such as degradation of misfolded proteins, regulation of short-lived proteins and housekeeping removal of dysfunctional proteins. They are also implicated in the control of cell growth, targeting DNA-binding protein from starved cells. The functional Clp protease is comprised of two components: a proteolytic component and one of several regulatory ATPase components, both of which are required for effective levels of protease activity in the presence of ATP. Active site consists of the triad Ser, His and Asp, preferring hydrophobic or non-polar residues at P1 or P1' positions. The protease exists as a tetradecamer made up of two heptameric rings stacked back-to-back such that the catalytic triad of each subunit is located at the interface between three monomers, thus making oligomerization essential for function. Another family included in this class of enzymes is the signal peptide peptidase A (SppA; S49) which is involved in the cleavage of signal peptides after their removal from the precursor proteins by signal peptidases. Mutagenesis studies suggest that the catalytic center of SppA comprises a Ser-Lys dyad and not the usual Ser-His-Asp catalytic triad found in the majority of serine proteases. In addition to the carboxyl-terminal protease domain that is conserved in all the S49 family members, the E. coli SppA contains an amino-terminal domain. Others, including sohB peptidase, protein C, protein 1510-N and archaeal signal peptide peptidase, do not contain the amino-terminal domain. The third family included in this hierarchy is nodulation formation efficiency D (NfeD) which is a membrane-bound Clp-class protease and only found in bacteria and archaea. Majority of the NfeD genomes have been shown to possess operons containing a homologous NfeD/stomatin gene pair, causing NfeD to be previously named stomatin operon partner protein (STOPP). NfeD homologs can be divided into two groups: long and short forms. Long-form homologs have a putative ClpP-class serine protease domain while the short form homologs do not. Downstream from the ClpP-class domain is the so-called NfeD or DUF107 domain. N-terminal region of the NfeD homolog PH1510 from Pyrococcus horikoshii has been shown to possess serine protease activity having a Ser-Lys catalytic dyad.


Pssm-ID: 132923 [Multi-domain]  Cd Length: 161  Bit Score: 45.46  E-value: 6.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169 121 ALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNLFIGIHATRFSFV----------ISKWMMNSYQSVL-------- 182
Cdd:cd00394  52 ALQASRKPVIAYVGGQAASAGYYIATAANKIVMAPGTRVGSHGPIGGYGgngnptaqeaDQRIILYFIARFIslvaenrg 131

                        90       100       110
                ....*....|....*....|....*....|
gi 45550169 183 -PRRIVERALNQGKLFASQEALDVGLVDEI 211
Cdd:cd00394 132 qTTEKLEEDIEKDLVLTAQEALEYGLVDAL 161
PRK11423 PRK11423
methylmalonyl-CoA decarboxylase; Provisional
 34-287 7.84e-06

methylmalonyl-CoA decarboxylase; Provisional


Pssm-ID: 236908 [Multi-domain]  Cd Length: 261  Bit Score: 46.17  E-value: 7.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   34 LTTIEVDDRsgIATLSMNLPP-VNTLTMELMHDLIDSINQIESNKSRGLILTS-SNDKVFSAGLDLNEMLNPDveRLRLF 111
Cdd:PRK11423   5 YVNVVTINK--IATITFNNPAkRNALSKVLIDDLMQALSDLNRPEIRVVILRApSGSKVWSAGHDIHELPSGG--RDPLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  112 WTR-FQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEyrvmlpnLFIGIHATRFSFVISKW--------MMNSYqSVL 182
Cdd:PRK11423  81 YDDpLRQILRMIQKFPKPVIAMVEGSVWGGAFELIMSCD-------LIIAASTSTFAMTPANLgvpynlsgILNFT-NDA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  183 PRRIVERALNQGKLFASQEALDVGLVDEIAcSKEEALSKCAAFIATFDKTNPVARCLTKRMCR--------EPDVRELLQ 254
Cdd:PRK11423 153 GFHIVKEMFFTASPITAQRALAVGILNHVV-EVEELEDFTLQMAHHISEKAPLAIAVIKEQLRvlgeahpmNPDEFERIQ 231

                        250       260       270
                 ....*....|....*....|....*....|...
gi 45550169  255 DRAADLKECVDYvttplfQEGLCAHLEglkKRK 287
Cdd:PRK11423 232 GLRRAVYDSEDY------QEGMNAFLE---KRK 255
PRK09120 PRK09120
p-hydroxycinnamoyl CoA hydratase/lyase; Validated
 31-246 8.24e-06

p-hydroxycinnamoyl CoA hydratase/lyase; Validated


Pssm-ID: 236383  Cd Length: 275  Bit Score: 46.16  E-value: 8.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   31 TSKLTTIEVDDRSGIATLSMNLP-PVNTLTMELMHDLIDSINQIESNKSRG-LILTSSNDKvFSAGLDLNE-MLNPD--- 104
Cdd:PRK09120   4 ENRWDTVKVEVEDGIAWVTLNRPeKRNAMSPTLNREMIDVLDALEFDDDAGvLVLTGAGDA-WSAGMDLKEyFRETDaqp 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  105 ---VERLRL----FWTRfqdlwlaLHLCGLPTAAAING------HSPAAGCVLATACEYRVM-LPNLFIGIHATRfsfVI 170
Cdd:PRK09120  83 eilQERIRReaygWWRR-------LRWYQKPTIAMVNGwcfgggFSPLVACDLAIAADEAQFgLSEINWGIPPGG---GV 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  171 SKWMmnsyQSVLPRRiveRALN---QGKLFASQEALDVGLVDEiACSKEEALSKCAAFIATFDKTNPVARCLTK---RMC 244
Cdd:PRK09120 153 SKAM----ADTVGHR---DALYyimTGETFTGRKAAEMGLVNE-SVPLAQLRARTRELAAKLLEKNPVVLRAAKdgfKRV 224


                 ..
gi 45550169  245 RE 246
Cdd:PRK09120 225 RE 226
PRK07468 PRK07468
crotonase/enoyl-CoA hydratase family protein;
36-287 1.52e-05

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180987 [Multi-domain]  Cd Length: 262  Bit Score: 45.44  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   36 TIEVDDRsGIATLSMNLPPV-NTLTMELMHDLIDSINQIESNKS-RGLILTSSNdKVFSAGLDLNEM---LNPDVERLRL 110
Cdd:PRK07468   7 RIAVDAR-GVATLTLNRPEKhNALSARMIAELTTAARRLAADAAvRVVVLTGAG-KSFCAGGDLGWMraqMTADRATRIE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  111 FWTRFQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNLFIGIHATRFSFV---ISKWMMNSYQSVLPRRIv 187
Cdd:PRK07468  85 EARRLAMMLKALNDLPKPLIGRIQGQAFGGGVGLISVCDVAIAVSGARFGLTETRLGLIpatISPYVVARMGEANARRV- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  188 eraLNQGKLFASQEALDVGLVDEIAcsKEEAL-SKCAAFIATFDKTNPVARCLTKRMCREPDVRELLQDRAADLKECVDY 266
Cdd:PRK07468 164 ---FMSARLFDAEEAVRLGLLSRVV--PAERLdAAVEAEVTPYLSCAPGAVAAAKALVRALGAPIDEAVIDATIEALADT 238

                        250       260
                 ....*....|....*....|.
gi 45550169  267 VTTPLFQEGLCAHLEglkKRK 287
Cdd:PRK07468 239 WETEEAREGIAAFFD---KRA 256
PRK05981 PRK05981
enoyl-CoA hydratase/isomerase;
30-211 1.70e-05

enoyl-CoA hydratase/isomerase;


Pssm-ID: 235661  Cd Length: 266  Bit Score: 45.11  E-value: 1.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   30 ATSKLTTIEVDDrsGIATLSMNLPPV-NTLTMELMHDLIDSINQIESNKS--RGLILT-------------------SSN 87
Cdd:PRK05981   1 MQFKKVTLDFDG--GVAILTLDHPEVmNAVSIDMLGGLAEALDAIEDGKAevRCLVLTgagrgfctganlqgrgsggRES 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   88 DKVFSAGLDLNEMLNPDVERLRLFwtrfqdlwlalhlcGLPTAAAINGHSPAAGCVLATACEYRVMLPNLFIGIHATRFS 167
Cdd:PRK05981  79 DSGGDAGAALETAYHPFLRRLRNL--------------PCPIVTAVNGPAAGVGMSFALMGDLILCARSAYFLQAFRRIG 144

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 45550169  168 FVI---SKWMmnsyqsvLPR-----RIVERALNQGKLFASQeALDVGLVDEI 211
Cdd:PRK05981 145 LVPdggSTWL-------LPRlvgkaRAMELSLLGEKLPAET-ALQWGLVNRV 188
PRK05864 PRK05864
enoyl-CoA hydratase; Provisional
 42-242 1.80e-05

enoyl-CoA hydratase; Provisional


Pssm-ID: 168278 [Multi-domain]  Cd Length: 276  Bit Score: 45.21  E-value: 1.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   42 RSGIATLSMNLPP-VNTLTMELMHDLIDSINQIE-SNKSRGLILTSSNdKVFSAGLDLNEMLN-PDVERLrlfwTR---- 114
Cdd:PRK05864  17 RPEIALITLNRPErMNSMAFDVMVPLKEALAEVSyDNSVRVVVLTGAG-RGFSSGADHKSAGVvPHVEGL----TRptya 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  115 ------FQDLWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPNLFI-------GIHATRFSFviskwmmnSYqsV 181
Cdd:PRK05864  92 lrsmelLDDVILALRRLHQPVIAAVNGPAIGGGLCLALAADIRVASSSAYFraaginnGLTASELGL--------SY--L 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45550169  182 LPRRI-VERALN---QGKLFASQEALDVGLVDEiACSKEEALSKC---AAFIATFDKTNPVarcLTKR 242
Cdd:PRK05864 162 LPRAIgSSRAFEimlTGRDVDAEEAERIGLVSR-QVPDEQLLDTCyaiAARMAGFSRPGIE---LTKR 225
PRK07110 PRK07110
polyketide biosynthesis enoyl-CoA hydratase; Validated
 31-153 7.41e-05

polyketide biosynthesis enoyl-CoA hydratase; Validated


Pssm-ID: 235936  Cd Length: 249  Bit Score: 43.03  E-value: 7.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   31 TSKLTTIEVDDrsGIATLSMNlPPV--NTLTMELMHDLIDSINQIESNKS-RGLILTSSnDKVFSAGLDLNEMLnpdveR 107
Cdd:PRK07110   3 MKVVELREVEE--GIAQVTMQ-DRVnkNAFSDELCDQLHEAFDTIAQDPRyKVVILTGY-PNYFATGGTQEGLL-----S 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 45550169  108 LRLFWTRFQD--LWLALHLCGLPTAAAINGHSPAAGCVLATACEYRVM 153
Cdd:PRK07110  74 LQTGKGTFTEanLYSLALNCPIPVIAAMQGHAIGGGLVLGLYADIVVL 121
PRK08150 PRK08150
crotonase/enoyl-CoA hydratase family protein;
39-208 1.11e-04

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181254  Cd Length: 255  Bit Score: 42.70  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   39 VDDRSGIATLSMNLPPV-NTLTMELMHDLIDSINQIESNkSRGLILTSSNDKvFSAGLDLNEMLNPD---VERLRLFWTR 114
Cdd:PRK08150   6 YELDGGVATIGLNRPAKrNALNDGLIAALRAAFARLPEG-VRAVVLHGEGDH-FCAGLDLSELRERDageGMHHSRRWHR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  115 FQDLwlaLHLCGLPTAAAINGHSPAAGCVLATACEYRVMLPN-----------LFIGIHAT-RFSFVISKwmmnsyqsvl 182
Cdd:PRK08150  84 VFDK---IQYGRVPVIAALHGAVVGGGLELASAAHIRVADEStyfalpegqrgIFVGGGGSvRVPRLIGV---------- 150

                        170       180
                 ....*....|....*....|....*.
gi 45550169  183 pRRIVERALNqGKLFASQEALDVGLV 208
Cdd:PRK08150 151 -ARMTDMMLT-GRVYDAQEGERLGLA 174
S49_SppA cd07014
Signal peptide peptidase A; Signal peptide peptidase A (SppA; Peptidase S49; Protease IV): ...
 126-223 7.73e-04

Signal peptide peptidase A; Signal peptide peptidase A (SppA; Peptidase S49; Protease IV): SppA is an intramembrane enzyme found in all three domains of life and is involved in the cleavage of signal peptides after their removal from the precursor proteins by signal peptidases. Unlike the eukaryotic functional homologs that are proposed to be aspartic proteases, site-directed mutagenesis and sequence analysis have shown these bacterial, archaeal and thylakoid SppAs to be ClpP-like serine proteases. The predicted active site serine for members in this family occurs in a transmembrane domain, cleaving peptide bonds in the plane of the lipid bilayer. Mutagenesis studies also suggest that the catalytic center comprises a Ser-Lys dyad (both residues absolutely conserved within bacteria, chloroplast and mitochondrial signal peptidase family members) and not the usual Ser-His-Asp catalytic triad found in the majority of serine proteases. In addition to the carboxyl-terminal protease domain that is conserved in all the S49 family members, the E. coli SppA contains an amino-terminal domain (sometimes referred to as 67K type). Others, including sohB peptidase, protein C, protein 1510-N and archaeal signal peptide peptidase, do not contain the amino-terminal domain (sometimes referred to as 36K type). Interestingly, the single membrane spanning E. coli SppA carries out catalysis using a Ser-Lys dyad with the serine located in the conserved carboxy-terminal protease domain and the lysine in the non-conserved amino-terminal domain. This family also contains homologs that either have been found experimentally to be without peptidase activity, or lack amino acid residues that are believed to be essential for the catalytic activity of peptidases.


Pssm-ID: 132925 [Multi-domain]  Cd Length: 177  Bit Score: 39.52  E-value: 7.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169 126 GLPTAAAINGHSPAAGCVLATACEYRVMLPNLFIGIHATRFS-FVISKWMMNSYQSVL---------PRRIVERALNQGK 195
Cdd:cd07014  71 GKPVVASGGGNAASGGYWISTPANYIVANPSTLVGSIGIFGVqLADQLSIENGYKRFItlvadnrhsTPEQQIDKIAQGG 150

                        90       100
                ....*....|....*....|....*...
gi 45550169 196 LFASQEALDVGLVDEIAcSKEEALSKCA 223
Cdd:cd07014 151 VWTGQDAKANGLVDSLG-SFDDAVAKLA 177
PRK08788 PRK08788
enoyl-CoA hydratase; Validated
 36-212 5.17e-03

enoyl-CoA hydratase; Validated


Pssm-ID: 236338  Cd Length: 287  Bit Score: 37.58  E-value: 5.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   36 TIEVDDRSGIATLSMNLPPVNTLTMELMHDLIDSINQIESNKSRG------LILTSSNDKVFSAGLDLN---EML-NPDV 105
Cdd:PRK08788  18 RVYYEEERNVMWMYMRAQPRPCFNLELLDDIMNLQRAIRQRLDDSglpvdfWVLASDVPGVFNLGGDLAlfaELIrAGDR 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169  106 ERLRLFWTRFQDL--WLALHL-CGLPTAAAINGHSPAAGCVLATACEYRV-----------MLPNLFIGihatrfsfvis 171
Cdd:PRK08788  98 DALLAYARACVDGvhAFHRGFgAGAISIALVQGDALGGGFEAALSHHTIIaergakmgfpeILFNLFPG----------- 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 45550169  172 kwmMNSYqSVLPRRI----VERALNQGKLFASQEALDVGLVDEIA 212
Cdd:PRK08788 167 ---MGAY-SFLARRVgpklAEELILSGKLYTAEELHDMGLVDVLV 207
PRK03580 PRK03580
crotonobetainyl-CoA hydratase;
79-211 8.40e-03

crotonobetainyl-CoA hydratase;


Pssm-ID: 179599 [Multi-domain]  Cd Length: 261  Bit Score: 36.98  E-value: 8.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550169   79 RGLILTSSNDKVFSAGLDL---NEMLNPDVERLRLFWTRFQDLWlALHlcgLPTAAAINGHSPAAGCVLATACEYRVMLP 155
Cdd:PRK03580  48 RVAIITGAGEKFFSAGWDLkaaAEGEAPDADFGPGGFAGLTEIF-DLD---KPVIAAVNGYAFGGGFELALAADFIVCAD 123

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 45550169  156 NLFIGIHATRFSFVISKWMMNSYQSVLPRRIVERALNQGKLFASQEALDVGLVDEI 211
Cdd:PRK03580 124 NASFALPEAKLGIVPDSGGVLRLPKRLPPAIANEMVMTGRRMDAEEALRWGIVNRV 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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