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Conserved domains on  [gi|19920906|ref|NP_609177|]
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connector of kinase to AP-1, isoform A [Drosophila melanogaster]

Protein Classification

striatin( domain architecture ID 10548818)

striatin, a WD40 repeat protein which may function as scaffolding or signaling protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 410-729 1.65e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 199.87  E-value: 1.65e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 410 TLRSHFDGVRSLIFHPEEPVLITASEDHTLKLWNLQktvqakksaslDVEPLYTFRAHTGPVLCLGMSSSGETCYSGGLD 489
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASGSSD 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 490 GNIECWQLPSPNIdpydcydpnvhSGTLEGHTDAVWGLTTMQSN--IVSCSADGTVKLWSPYNKEPLlrtYTASEAEGVP 567
Cdd:cd00200  73 KTIRLWDLETGEC-----------VRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCL---TTLRGHTDWV 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 568 SSVDFvrNEVDHIVVAYNSAHCI-VYDTETGKQVVRLEaaqemsGNTGkFINKVVSHPTLPITITAHEDRHIRFWDNTSG 646
Cdd:cd00200 139 NSVAF--SPDGTFVASSSQDGTIkLWDLRTGKCVATLT------GHTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 647 TLVHSMVAHLEPVTSLAVDAHGLYLLSGSHDCSIRLWNLDNKTCVQEITAHrkkfDESIFDVAFHATKPYIASAGADGLA 726
Cdd:cd00200 210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH----TNSVTSLAWSPDGKRLASGSADGTI 285


                ...
gi 19920906 727 KVF 729
Cdd:cd00200 286 RIW 288
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 99-228 6.43e-38

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


:

Pssm-ID: 462401  Cd Length: 85  Bit Score: 135.71  E-value: 6.43e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906    99 IPGILHFIQHEWSRFELERSQWDVDRAELQARIAMLLGERKCLESLKSDLTRRIKMLEYALRQERakfyrlkygtdppql 178
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 19920906   179 nefkpsnedaglagevatdsevpyssvsntTWRQGRQMLRQYLAEIGYTD 228
Cdd:pfam08232  66 ------------------------------KRKKSRQYLKKCLQEIGYLD 85
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 410-729 1.65e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 199.87  E-value: 1.65e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 410 TLRSHFDGVRSLIFHPEEPVLITASEDHTLKLWNLQktvqakksaslDVEPLYTFRAHTGPVLCLGMSSSGETCYSGGLD 489
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASGSSD 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 490 GNIECWQLPSPNIdpydcydpnvhSGTLEGHTDAVWGLTTMQSN--IVSCSADGTVKLWSPYNKEPLlrtYTASEAEGVP 567
Cdd:cd00200  73 KTIRLWDLETGEC-----------VRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCL---TTLRGHTDWV 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 568 SSVDFvrNEVDHIVVAYNSAHCI-VYDTETGKQVVRLEaaqemsGNTGkFINKVVSHPTLPITITAHEDRHIRFWDNTSG 646
Cdd:cd00200 139 NSVAF--SPDGTFVASSSQDGTIkLWDLRTGKCVATLT------GHTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 647 TLVHSMVAHLEPVTSLAVDAHGLYLLSGSHDCSIRLWNLDNKTCVQEITAHrkkfDESIFDVAFHATKPYIASAGADGLA 726
Cdd:cd00200 210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH----TNSVTSLAWSPDGKRLASGSADGTI 285


                ...
gi 19920906 727 KVF 729
Cdd:cd00200 286 RIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
410-728 6.59e-48

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 174.33  E-value: 6.59e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 410 TLRSHFDGVRSLIFHPEEPVLITASEDHTLKLWNLQKTvqakksasldvEPLYTFRAHTGPVLCLGMSSSGETCYSGGLD 489
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-----------KLLRTLTGHSGAVTSVAFSPDGKLLASGSDD 183

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 490 GNIECWQLPSPNIdpydcydpnvhSGTLEGHTDAVWGLT-TMQSN-IVSCSADGTVKLWSPYNKEpLLRTYTASEaeGVP 567
Cdd:COG2319 184 GTVRLWDLATGKL-----------LRTLTGHTGAVRSVAfSPDGKlLASGSADGTVRLWDLATGK-LLRTLTGHS--GSV 249

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 568 SSVDFVRNEvDHIVVAYNSAHCIVYDTETGKQVVRLEaaqemsGNTGKfINKVVSHPTLPITITAHEDRHIRFWDNTSGT 647
Cdd:COG2319 250 RSVAFSPDG-RLLASGSADGTVRLWDLATGELLRTLT------GHSGG-VNSVAFSPDGKLLASGSDDGTVRLWDLATGK 321

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 648 LVHSMVAHLEPVTSLAVDAHGLYLLSGSHDCSIRLWNLDNKTCVQEITAHrkkfDESIFDVAFHATKPYIASAGADGLAK 727
Cdd:COG2319 322 LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH----TGAVTSVAFSPDGRTLASGSADGTVR 397


                .
gi 19920906 728 V 728
Cdd:COG2319 398 L 398
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 99-228 6.43e-38

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


Pssm-ID: 462401  Cd Length: 85  Bit Score: 135.71  E-value: 6.43e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906    99 IPGILHFIQHEWSRFELERSQWDVDRAELQARIAMLLGERKCLESLKSDLTRRIKMLEYALRQERakfyrlkygtdppql 178
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 19920906   179 nefkpsnedaglagevatdsevpyssvsntTWRQGRQMLRQYLAEIGYTD 228
Cdd:pfam08232  66 ------------------------------KRKKSRQYLKKCLQEIGYLD 85
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 645-684 6.71e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 6.71e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19920906    645 SGTLVHSMVAHLEPVTSLAVDAHGLYLLSGSHDCSIRLWN 684
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
646-684 2.71e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 2.71e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 19920906   646 GTLVHSMVAHLEPVTSLAVDAHGLYLLSGSHDCSIRLWN 684
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 410-729 1.65e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 199.87  E-value: 1.65e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 410 TLRSHFDGVRSLIFHPEEPVLITASEDHTLKLWNLQktvqakksaslDVEPLYTFRAHTGPVLCLGMSSSGETCYSGGLD 489
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASGSSD 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 490 GNIECWQLPSPNIdpydcydpnvhSGTLEGHTDAVWGLTTMQSN--IVSCSADGTVKLWSPYNKEPLlrtYTASEAEGVP 567
Cdd:cd00200  73 KTIRLWDLETGEC-----------VRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCL---TTLRGHTDWV 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 568 SSVDFvrNEVDHIVVAYNSAHCI-VYDTETGKQVVRLEaaqemsGNTGkFINKVVSHPTLPITITAHEDRHIRFWDNTSG 646
Cdd:cd00200 139 NSVAF--SPDGTFVASSSQDGTIkLWDLRTGKCVATLT------GHTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 647 TLVHSMVAHLEPVTSLAVDAHGLYLLSGSHDCSIRLWNLDNKTCVQEITAHrkkfDESIFDVAFHATKPYIASAGADGLA 726
Cdd:cd00200 210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH----TNSVTSLAWSPDGKRLASGSADGTI 285


                ...
gi 19920906 727 KVF 729
Cdd:cd00200 286 RIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
410-728 6.59e-48

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 174.33  E-value: 6.59e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 410 TLRSHFDGVRSLIFHPEEPVLITASEDHTLKLWNLQKTvqakksasldvEPLYTFRAHTGPVLCLGMSSSGETCYSGGLD 489
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-----------KLLRTLTGHSGAVTSVAFSPDGKLLASGSDD 183

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 490 GNIECWQLPSPNIdpydcydpnvhSGTLEGHTDAVWGLT-TMQSN-IVSCSADGTVKLWSPYNKEpLLRTYTASEaeGVP 567
Cdd:COG2319 184 GTVRLWDLATGKL-----------LRTLTGHTGAVRSVAfSPDGKlLASGSADGTVRLWDLATGK-LLRTLTGHS--GSV 249

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 568 SSVDFVRNEvDHIVVAYNSAHCIVYDTETGKQVVRLEaaqemsGNTGKfINKVVSHPTLPITITAHEDRHIRFWDNTSGT 647
Cdd:COG2319 250 RSVAFSPDG-RLLASGSADGTVRLWDLATGELLRTLT------GHSGG-VNSVAFSPDGKLLASGSDDGTVRLWDLATGK 321

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 648 LVHSMVAHLEPVTSLAVDAHGLYLLSGSHDCSIRLWNLDNKTCVQEITAHrkkfDESIFDVAFHATKPYIASAGADGLAK 727
Cdd:COG2319 322 LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH----TGAVTSVAFSPDGRTLASGSADGTVR 397


                .
gi 19920906 728 V 728
Cdd:COG2319 398 L 398
WD40 COG2319
WD40 repeat [General function prediction only];
403-687 5.33e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.29  E-value: 5.33e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 403 KTWNAK-----YTLRSHFDGVRSLIFHPEEPVLITASEDHTLKLWNLQKTvqakksasldvEPLYTFRAHTGPVLCLGMS 477
Cdd:COG2319 145 RLWDLAtgkllRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-----------KLLRTLTGHTGAVRSVAFS 213

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 478 SSGETCYSGGLDGNIECWQLPSPNIdpydcydpnvhSGTLEGHTDAVWGLTTMQSN--IVSCSADGTVKLWSPYNKEpLL 555
Cdd:COG2319 214 PDGKLLASGSADGTVRLWDLATGKL-----------LRTLTGHSGSVRSVAFSPDGrlLASGSADGTVRLWDLATGE-LL 281

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 556 RTYTASEaeGVPSSVDFVRNEvDHIVVAYNSAHCIVYDTETGKQVVRLeaaqemSGNTGKfINKVVSHPTLPITITAHED 635
Cdd:COG2319 282 RTLTGHS--GGVNSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTL------TGHTGA-VRSVAFSPDGKTLASGSDD 351

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 19920906 636 RHIRFWDNTSGTLVHSMVAHLEPVTSLAVDAHGLYLLSGSHDCSIRLWNLDN 687
Cdd:COG2319 352 GTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 99-228 6.43e-38

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


Pssm-ID: 462401  Cd Length: 85  Bit Score: 135.71  E-value: 6.43e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906    99 IPGILHFIQHEWSRFELERSQWDVDRAELQARIAMLLGERKCLESLKSDLTRRIKMLEYALRQERakfyrlkygtdppql 178
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 19920906   179 nefkpsnedaglagevatdsevpyssvsntTWRQGRQMLRQYLAEIGYTD 228
Cdd:pfam08232  66 ------------------------------KRKKSRQYLKKCLQEIGYLD 85
WD40 COG2319
WD40 repeat [General function prediction only];
404-729 4.46e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.96  E-value: 4.46e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 404 TWNAKYTLRSHFDGVRSLIFHPEEPVLITASEDHTLKLWNLQKTvqakksasldvEPLYTFRAHTGPVLCLGMSSSGETC 483
Cdd:COG2319  67 AGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG-----------LLLRTLTGHTGAVRSVAFSPDGKTL 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 484 YSGGLDGNIECWQLPSPNIdpydcydpnvhSGTLEGHTDAVWGLT-----TMqsnIVSCSADGTVKLWSPYNKEpLLRTY 558
Cdd:COG2319 136 ASGSADGTVRLWDLATGKL-----------LRTLTGHSGAVTSVAfspdgKL---LASGSDDGTVRLWDLATGK-LLRTL 200

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 559 TASEaeGVPSSVDFVRNevdhivvaynsahcivydtetGKQVVrleaaqemsgntgkfinkvvshptlpitiTAHEDRHI 638
Cdd:COG2319 201 TGHT--GAVRSVAFSPD---------------------GKLLA-----------------------------SGSADGTV 228

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 639 RFWDNTSGTLVHSMVAHLEPVTSLAVDAHGLYLLSGSHDCSIRLWNLDNKTCVQEITAHrkkfDESIFDVAFHATKPYIA 718
Cdd:COG2319 229 RLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH----SGGVNSVAFSPDGKLLA 304

                       330
                ....*....|.
gi 19920906 719 SAGADGLAKVF 729
Cdd:COG2319 305 SGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 513-729 4.66e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.52  E-value: 4.66e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 513 HSGTLEGHTDAVWGL--TTMQSNIVSCSADGTVKLWSpYNKEPLLRTYTasEAEGVPSSVDFVRNEvDHIVVAYNSAHCI 590
Cdd:cd00200   1 LRRTLKGHTGGVTCVafSPDGKLLATGSGDGTIKVWD-LETGELLRTLK--GHTGPVRDVAASADG-TYLASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 591 VYDTETGKQVVRLEAAQEMsgntgkfINKVVSHPTLPITITAHEDRHIRFWDNTSGTLVHSMVAHLEPVTSLAVDAHGLY 670
Cdd:cd00200  77 LWDLETGECVRTLTGHTSY-------VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF 149

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 19920906 671 LLSGSHDCSIRLWNLDNKTCVQEITAHrkkfDESIFDVAFHATKPYIASAGADGLAKVF 729
Cdd:cd00200 150 VASSSQDGTIKLWDLRTGKCVATLTGH----TGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
410-729 4.02e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.40  E-value: 4.02e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 410 TLRSHFDGVRSLIFHPEEPVLITASEDHTLKLWNLQKTvqakksasldvEPLYTFRAHTGPVLCLGMSSSGETCYSGGLD 489
Cdd:COG2319  31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-----------ALLATLLGHTAAVLSVAFSPDGRLLASASAD 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 490 GNIECWQLPSPnidpydcydpnVHSGTLEGHTDAVWGLT-----TMqsnIVSCSADGTVKLWSPYNKEPLlrtYTASEAE 564
Cdd:COG2319 100 GTVRLWDLATG-----------LLLRTLTGHTGAVRSVAfspdgKT---LASGSADGTVRLWDLATGKLL---RTLTGHS 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 565 GVPSSVDFVRNevdhivvaynsahcivydtetGKQVVrleaaqemsgntgkfinkvvshptlpitiTAHEDRHIRFWDNT 644
Cdd:COG2319 163 GAVTSVAFSPD---------------------GKLLA-----------------------------SGSDDGTVRLWDLA 192

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920906 645 SGTLVHSMVAHLEPVTSLAVDAHGLYLLSGSHDCSIRLWNLDNKTCVQEITAHrkkfDESIFDVAFHATKPYIASAGADG 724
Cdd:COG2319 193 TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH----SGSVRSVAFSPDGRLLASGSADG 268


                ....*
gi 19920906 725 LAKVF 729
Cdd:COG2319 269 TVRLW 273
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 645-684 6.71e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 6.71e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19920906    645 SGTLVHSMVAHLEPVTSLAVDAHGLYLLSGSHDCSIRLWN 684
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
646-684 2.71e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 2.71e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 19920906   646 GTLVHSMVAHLEPVTSLAVDAHGLYLLSGSHDCSIRLWN 684
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 404-443 3.73e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 3.73e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19920906    404 TWNAKYTLRSHFDGVRSLIFHPEEPVLITASEDHTLKLWN 443
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
405-443 9.50e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 9.50e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 19920906   405 WNAKYTLRSHFDGVRSLIFHPEEPVLITASEDHTLKLWN 443
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 459-495 7.72e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 7.72e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 19920906    459 EPLYTFRAHTGPVLCLGMSSSGETCYSGGLDGNIECW 495
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
459-495 2.84e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 2.84e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 19920906   459 EPLYTFRAHTGPVLCLGMSSSGETCYSGGLDGNIECW 495
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 516-547 5.29e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 5.29e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 19920906    516 TLEGHTDAVWGLTTMQSN--IVSCSADGTVKLWS 547
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGkyLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
515-547 6.28e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 6.28e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 19920906   515 GTLEGHTDAVWGLTTMQSN--IVSCSADGTVKLWS 547
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGklLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 687-729 1.61e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.61e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 19920906    687 NKTCVQEITAHRKkfdeSIFDVAFHATKPYIASAGADGLAKVF 729
Cdd:smart00320   1 SGELLKTLKGHTG----PVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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