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Conserved domains on  [gi|20129303|ref|NP_609088|]
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Ada2a-containing complex component 1 [Drosophila melanogaster]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 10073748)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein binds DNA and may function as a transcription factor

CATH:  1.20.58.1880
Gene Ontology:  GO:0006355|GO:0003677|GO:0003700
PubMed:  8882580|15040448|16877755
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 135-183 7.98e-07

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


:

Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 45.26  E-value: 7.98e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 20129303 135 WTNEEQSRLEQLLIQYPpeeveMRRFGKIAKALGNRTAQQVYSRVQKYF 183
Cdd:cd00167   2 WTEEEDELLLEAVKKYG-----KNNWEKIAKELPGRTPKQCRERWRNLL 45
 
Name Accession Description Interval E-value
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 135-183 7.98e-07

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 45.26  E-value: 7.98e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 20129303 135 WTNEEQSRLEQLLIQYPpeeveMRRFGKIAKALGNRTAQQVYSRVQKYF 183
Cdd:cd00167   2 WTEEEDELLLEAVKKYG-----KNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
135-185 2.51e-06

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 44.14  E-value: 2.51e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 20129303    135 WTNEEQSRLEQLLIQYPpeeveMRRFGKIAKALGNRTAQQVYSRVQKYFQK 185
Cdd:smart00717   4 WTEEEDELLIELVKKYG-----KNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 135-183 5.99e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 42.88  E-value: 5.99e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 20129303   135 WTNEEQSRLEQLLIQYPpeevemRRFGKIAKALGNRTAQQVYSRVQKYF 183
Cdd:pfam00249   4 WTPEEDELLLEAVEKLG------NRWKKIAKLLPGRTDNQCKNRWQNYL 46
 
Name Accession Description Interval E-value
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 135-183 7.98e-07

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 45.26  E-value: 7.98e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 20129303 135 WTNEEQSRLEQLLIQYPpeeveMRRFGKIAKALGNRTAQQVYSRVQKYF 183
Cdd:cd00167   2 WTEEEDELLLEAVKKYG-----KNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
135-185 2.51e-06

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 44.14  E-value: 2.51e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 20129303    135 WTNEEQSRLEQLLIQYPpeeveMRRFGKIAKALGNRTAQQVYSRVQKYFQK 185
Cdd:smart00717   4 WTEEEDELLIELVKKYG-----KNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 135-183 5.99e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 42.88  E-value: 5.99e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 20129303   135 WTNEEQSRLEQLLIQYPpeevemRRFGKIAKALGNRTAQQVYSRVQKYF 183
Cdd:pfam00249   4 WTPEEDELLLEAVEKLG------NRWKKIAKLLPGRTDNQCKNRWQNYL 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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