NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1834199230|ref|NP_609045|]
View 

intraflagellar transport 52 [Drosophila melanogaster]

Protein Classification

motility-associated ABC transporter substrate-binding family protein( domain architecture ID 581101)

motility-associated ABC transporter substrate-binding family protein such as the human intraflagellar transport protein Ift52, which is involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
IFT52_CTD cd23683
C-terminal domain of intraflagellar transport protein 52 (IFT52) and similar proteins; IFT52 ...
 353-429 5.31e-11

C-terminal domain of intraflagellar transport protein 52 (IFT52) and similar proteins; IFT52 is involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance, and functioning of primary cilia. It is required for the anterograde transport of IFT88. IFT52 is a component of the IFT complex B that consists of a 9-subunit salt-stable core and several peripheral subunits. The model corresponds to the C-terminal domain of IFT52, which is responsible for binding to the C-terminal domain of IFT46.


:

Pssm-ID: 467897  Cd Length: 69  Bit Score: 57.93  E-value: 5.31e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1834199230 353 YDLDETFSGARSQLAHMTGQVlqalqskepqrraLNQRELENYIKECARITAIVDE--RQDMAAREILNIVARQIISYR 429
Cdd:cd23683     1 FDLDEAFASERVRLAQLTNKC-------------TADDDLEYYIRECGDILGITSKlpEDERSAKHILEHVFRQLVEFK 66
ABC_transp_aux super family cl23805
ABC-type uncharacterized transport system; This domain is found in various eukaryotic and ...
 1-115 2.92e-08

ABC-type uncharacterized transport system; This domain is found in various eukaryotic and prokaryotic intra-flagellar transport proteins involved in gliding motility, as well as in several hypothetical proteins.


The actual alignment was detected with superfamily member pfam09822:

Pssm-ID: 451555  Cd Length: 264  Bit Score: 54.58  E-value: 2.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834199230   1 MSSKPVICFDTSKNERFqiSDNYKMMHRKLKVNWNVEQNDAELRMERLARVKIFVLAGPQDRFTEDEFDVLKHYVEvQGG 80
Cdd:pfam09822 143 DPEKPKVGFLTGHGELS--DDPLADFLEELSENYDVEEVDLDSVAILPEDFDVLVIAKPTKDLSEEEKYALDQFLM-NGG 219

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1834199230  81 SLVVL----------LGEGGEPEFNTNVNFFLEQYGIYINGDTVV 115
Cdd:pfam09822 220 KLLWFvdpvavdldsLGGALAAPRDLNLDDLLFKYGVRINPDLVL 264
 
Name Accession Description Interval E-value
IFT52_CTD cd23683
C-terminal domain of intraflagellar transport protein 52 (IFT52) and similar proteins; IFT52 ...
 353-429 5.31e-11

C-terminal domain of intraflagellar transport protein 52 (IFT52) and similar proteins; IFT52 is involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance, and functioning of primary cilia. It is required for the anterograde transport of IFT88. IFT52 is a component of the IFT complex B that consists of a 9-subunit salt-stable core and several peripheral subunits. The model corresponds to the C-terminal domain of IFT52, which is responsible for binding to the C-terminal domain of IFT46.


Pssm-ID: 467897  Cd Length: 69  Bit Score: 57.93  E-value: 5.31e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1834199230 353 YDLDETFSGARSQLAHMTGQVlqalqskepqrraLNQRELENYIKECARITAIVDE--RQDMAAREILNIVARQIISYR 429
Cdd:cd23683     1 FDLDEAFASERVRLAQLTNKC-------------TADDDLEYYIRECGDILGITSKlpEDERSAKHILEHVFRQLVEFK 66
ABC_transp_aux pfam09822
ABC-type uncharacterized transport system; This domain is found in various eukaryotic and ...
 1-115 2.92e-08

ABC-type uncharacterized transport system; This domain is found in various eukaryotic and prokaryotic intra-flagellar transport proteins involved in gliding motility, as well as in several hypothetical proteins.


Pssm-ID: 430853  Cd Length: 264  Bit Score: 54.58  E-value: 2.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834199230   1 MSSKPVICFDTSKNERFqiSDNYKMMHRKLKVNWNVEQNDAELRMERLARVKIFVLAGPQDRFTEDEFDVLKHYVEvQGG 80
Cdd:pfam09822 143 DPEKPKVGFLTGHGELS--DDPLADFLEELSENYDVEEVDLDSVAILPEDFDVLVIAKPTKDLSEEEKYALDQFLM-NGG 219

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1834199230  81 SLVVL----------LGEGGEPEFNTNVNFFLEQYGIYINGDTVV 115
Cdd:pfam09822 220 KLLWFvdpvavdldsLGGALAAPRDLNLDDLLFKYGVRINPDLVL 264
GldG COG3225
ABC-type uncharacterized transport system involved in gliding motility, auxiliary component ...
 1-115 2.70e-07

ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility];


Pssm-ID: 442458 [Multi-domain]  Cd Length: 494  Bit Score: 52.63  E-value: 2.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834199230   1 MSSKPVICFDTSKNERfQISDNYKMMHRKLK-VNWNVEQNDAELRMERLARVKIFVLAGPQDRFTEDEFDVLKHYVEvQG 79
Cdd:COG3225   165 RTKKPKVGFLTGHGEL-SLDRDLSDFVEALEeKGYDVAPLNLDSAAEIPEDADVLVIAGPTKAFSEEEKYALDQYLM-RG 242

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1834199230  80 GSLVVLLG------EGGEPEFNTNVNFFLEQYGIYINGDTVV 115
Cdd:COG3225   243 GKLLWLLDpvnaelDSLAFPRDLGLDDLLFKYGVRLNPGLVV 284
 
Name Accession Description Interval E-value
IFT52_CTD cd23683
C-terminal domain of intraflagellar transport protein 52 (IFT52) and similar proteins; IFT52 ...
 353-429 5.31e-11

C-terminal domain of intraflagellar transport protein 52 (IFT52) and similar proteins; IFT52 is involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance, and functioning of primary cilia. It is required for the anterograde transport of IFT88. IFT52 is a component of the IFT complex B that consists of a 9-subunit salt-stable core and several peripheral subunits. The model corresponds to the C-terminal domain of IFT52, which is responsible for binding to the C-terminal domain of IFT46.


Pssm-ID: 467897  Cd Length: 69  Bit Score: 57.93  E-value: 5.31e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1834199230 353 YDLDETFSGARSQLAHMTGQVlqalqskepqrraLNQRELENYIKECARITAIVDE--RQDMAAREILNIVARQIISYR 429
Cdd:cd23683     1 FDLDEAFASERVRLAQLTNKC-------------TADDDLEYYIRECGDILGITSKlpEDERSAKHILEHVFRQLVEFK 66
ABC_transp_aux pfam09822
ABC-type uncharacterized transport system; This domain is found in various eukaryotic and ...
 1-115 2.92e-08

ABC-type uncharacterized transport system; This domain is found in various eukaryotic and prokaryotic intra-flagellar transport proteins involved in gliding motility, as well as in several hypothetical proteins.


Pssm-ID: 430853  Cd Length: 264  Bit Score: 54.58  E-value: 2.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834199230   1 MSSKPVICFDTSKNERFqiSDNYKMMHRKLKVNWNVEQNDAELRMERLARVKIFVLAGPQDRFTEDEFDVLKHYVEvQGG 80
Cdd:pfam09822 143 DPEKPKVGFLTGHGELS--DDPLADFLEELSENYDVEEVDLDSVAILPEDFDVLVIAKPTKDLSEEEKYALDQFLM-NGG 219

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1834199230  81 SLVVL----------LGEGGEPEFNTNVNFFLEQYGIYINGDTVV 115
Cdd:pfam09822 220 KLLWFvdpvavdldsLGGALAAPRDLNLDDLLFKYGVRINPDLVL 264
GldG COG3225
ABC-type uncharacterized transport system involved in gliding motility, auxiliary component ...
 1-115 2.70e-07

ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility];


Pssm-ID: 442458 [Multi-domain]  Cd Length: 494  Bit Score: 52.63  E-value: 2.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834199230   1 MSSKPVICFDTSKNERfQISDNYKMMHRKLK-VNWNVEQNDAELRMERLARVKIFVLAGPQDRFTEDEFDVLKHYVEvQG 79
Cdd:COG3225   165 RTKKPKVGFLTGHGEL-SLDRDLSDFVEALEeKGYDVAPLNLDSAAEIPEDADVLVIAGPTKAFSEEEKYALDQYLM-RG 242

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1834199230  80 GSLVVLLG------EGGEPEFNTNVNFFLEQYGIYINGDTVV 115
Cdd:COG3225   243 GKLLWLLDpvnaelDSLAFPRDLGLDDLLFKYGVRLNPGLVV 284
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH