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Conserved domains on  [gi|24582141|ref|NP_608995|]
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uncharacterized protein Dmel_CG9175, isoform A [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
169-383 1.58e-19

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.97  E-value: 1.58e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 169 FDIQAADVIQTdfLKGAEPLQRVVRISGNGRLMATGGTDGKLRVWTFPQMTLAAELAAHSKEIDDLDFSPDSKLIASISK 248
Cdd:COG2319 147 WDLATGKLLRT--LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSA 224

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 249 DAQGLVWDLASGQLQHKLQWKTPegakylfkrcRYGTVEAQKDNYRLFTianplgkvGKQRGFLQHWDCASGQLRQAVAI 328
Cdd:COG2319 225 DGTVRLWDLATGKLLRTLTGHSG----------SVRSVAFSPDGRLLAS--------GSADGTVRLWDLATGELLRTLTG 286

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 24582141 329 DES-LSSLAVRDDGRFVAVGTmFSGSVSMYiAFSLQRVLHIPHAHSMFVTGLQFLP 383
Cdd:COG2319 287 HSGgVNSVAFSPDGKLLASGS-DDGTVRLW-DLATGKLLRTLTGHTGAVRSVAFSP 340
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
169-383 1.58e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.97  E-value: 1.58e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 169 FDIQAADVIQTdfLKGAEPLQRVVRISGNGRLMATGGTDGKLRVWTFPQMTLAAELAAHSKEIDDLDFSPDSKLIASISK 248
Cdd:COG2319 147 WDLATGKLLRT--LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSA 224

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 249 DAQGLVWDLASGQLQHKLQWKTPegakylfkrcRYGTVEAQKDNYRLFTianplgkvGKQRGFLQHWDCASGQLRQAVAI 328
Cdd:COG2319 225 DGTVRLWDLATGKLLRTLTGHSG----------SVRSVAFSPDGRLLAS--------GSADGTVRLWDLATGELLRTLTG 286

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 24582141 329 DES-LSSLAVRDDGRFVAVGTmFSGSVSMYiAFSLQRVLHIPHAHSMFVTGLQFLP 383
Cdd:COG2319 287 HSGgVNSVAFSPDGKLLASGS-DDGTVRLW-DLATGKLLRTLTGHTGAVRSVAFSP 340
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 190-420 6.43e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.98  E-value: 6.43e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 190 RVVRISGNGRLMATGGTDGKLRVWTFPQMTLAAELAAHSKEIDDLDFSPDSKLIASISKDAQGLVWDLASGQLQHKLqwk 269
Cdd:cd00200  13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL--- 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 270 tpEGAKylfkrcryGTVeaqkdnyrlFTIA-NPLGKV---GKQRGFLQHWDCASGQLRQAV-AIDESLSSLAVRDDGRFV 344
Cdd:cd00200  90 --TGHT--------SYV---------SSVAfSPDGRIlssSSRDKTIKVWDVETGKCLTTLrGHTDWVNSVAFSPDGTFV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 345 AvgtmfSGSVSMYI------AFSLQRVLhipHAHSMFVTGLQFLPitneegppissdTEAAVLSISVDNKVCIHSLSQRR 418
Cdd:cd00200 151 A-----SSSQDGTIklwdlrTGKCVATL---TGHTGEVNSVAFSP------------DGEKLLSSSSDGTIKLWDLSTGK 210


                ..
gi 24582141 419 TI 420
Cdd:cd00200 211 CL 212
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 222-256 5.48e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 5.48e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 24582141    222 AELAAHSKEIDDLDFSPDSKLIASISKDAQGLVWD 256
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
218-256 4.03e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 4.03e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 24582141   218 MTLAAELAAHSKEIDDLDFSPDSKLIASISKDAQGLVWD 256
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
169-383 1.58e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.97  E-value: 1.58e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 169 FDIQAADVIQTdfLKGAEPLQRVVRISGNGRLMATGGTDGKLRVWTFPQMTLAAELAAHSKEIDDLDFSPDSKLIASISK 248
Cdd:COG2319 147 WDLATGKLLRT--LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSA 224

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 249 DAQGLVWDLASGQLQHKLQWKTPegakylfkrcRYGTVEAQKDNYRLFTianplgkvGKQRGFLQHWDCASGQLRQAVAI 328
Cdd:COG2319 225 DGTVRLWDLATGKLLRTLTGHSG----------SVRSVAFSPDGRLLAS--------GSADGTVRLWDLATGELLRTLTG 286

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 24582141 329 DES-LSSLAVRDDGRFVAVGTmFSGSVSMYiAFSLQRVLHIPHAHSMFVTGLQFLP 383
Cdd:COG2319 287 HSGgVNSVAFSPDGKLLASGS-DDGTVRLW-DLATGKLLRTLTGHTGAVRSVAFSP 340
WD40 COG2319
WD40 repeat [General function prediction only];
192-383 4.44e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.73  E-value: 4.44e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 192 VRISGNGRLMATGGTDGKLRVWTFPQMTLAAELAAHSKEIDDLDFSPDSKLIASISKDAQGLVWDLASGQLQHKLQWKT- 270
Cdd:COG2319 126 VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTg 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 271 --------PEGaKYLFKRCRYGTVeaqkdnyRLftianplgkvgkqrgflqhWDCASGQLRQAVAIDESL-SSLAVRDDG 341
Cdd:COG2319 206 avrsvafsPDG-KLLASGSADGTV-------RL-------------------WDLATGKLLRTLTGHSGSvRSVAFSPDG 258

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 24582141 342 RFVAVGTmFSGSVSMYiafSLQ--RVLHIPHAHSMFVTGLQFLP 383
Cdd:COG2319 259 RLLASGS-ADGTVRLW---DLAtgELLRTLTGHSGGVNSVAFSP 298
WD40 COG2319
WD40 repeat [General function prediction only];
169-383 2.66e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.34  E-value: 2.66e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 169 FDIQAADVIQTdfLKGAEPLQRVVRISGNGRLMATGGTDGKLRVWTFPQMTLAAELAAHSKEIDDLDFSPDSKLIASISK 248
Cdd:COG2319 189 WDLATGKLLRT--LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 249 DAQGLVWDLASGQLQHKLQWKT---------PEGaKYLFKRCRYGTVeaqkdnyRLftianplgkvgkqrgflqhWDCAS 319
Cdd:COG2319 267 DGTVRLWDLATGELLRTLTGHSggvnsvafsPDG-KLLASGSDDGTV-------RL-------------------WDLAT 319

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24582141 320 GQLRQAV-AIDESLSSLAVRDDGRFVAVGTMfSGSVSMYiAFSLQRVLHIPHAHSMFVTGLQFLP 383
Cdd:COG2319 320 GKLLRTLtGHTGAVRSVAFSPDGKTLASGSD-DGTVRLW-DLATGELLRTLTGHTGAVTSVAFSP 382
WD40 COG2319
WD40 repeat [General function prediction only];
136-383 4.39e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.49  E-value: 4.39e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 136 RQRNAHSGVEPVANGHRPPLSTADILRQFRRLHFDIQAADVIQTDFLKGAEPLQRVVRISGNGRLMATGGTDGKLRVWTF 215
Cdd:COG2319  28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 216 PQMTLAAELAAHSKEIDDLDFSPDSKLIASISKDAQGLVWDLASGQLQHKLQWKTpegakylfkrcryGTVEAqkdnyrl 295
Cdd:COG2319 108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHS-------------GAVTS------- 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 296 ftIA-NPLGK---VGKQRGFLQHWDCASGQLRQAVAI-DESLSSLAVRDDGRFVAVGTmFSGSVSMYiafSLQ--RVLHI 368
Cdd:COG2319 168 --VAfSPDGKllaSGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGKLLASGS-ADGTVRLW---DLAtgKLLRT 241

                       250
                ....*....|....*
gi 24582141 369 PHAHSMFVTGLQFLP 383
Cdd:COG2319 242 LTGHSGSVRSVAFSP 256
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 190-420 6.43e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.98  E-value: 6.43e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 190 RVVRISGNGRLMATGGTDGKLRVWTFPQMTLAAELAAHSKEIDDLDFSPDSKLIASISKDAQGLVWDLASGQLQHKLqwk 269
Cdd:cd00200  13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL--- 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 270 tpEGAKylfkrcryGTVeaqkdnyrlFTIA-NPLGKV---GKQRGFLQHWDCASGQLRQAV-AIDESLSSLAVRDDGRFV 344
Cdd:cd00200  90 --TGHT--------SYV---------SSVAfSPDGRIlssSSRDKTIKVWDVETGKCLTTLrGHTDWVNSVAFSPDGTFV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 345 AvgtmfSGSVSMYI------AFSLQRVLhipHAHSMFVTGLQFLPitneegppissdTEAAVLSISVDNKVCIHSLSQRR 418
Cdd:cd00200 151 A-----SSSQDGTIklwdlrTGKCVATL---TGHTGEVNSVAFSP------------DGEKLLSSSSDGTIKLWDLSTGK 210


                ..
gi 24582141 419 TI 420
Cdd:cd00200 211 CL 212
WD40 COG2319
WD40 repeat [General function prediction only];
169-347 1.84e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.87  E-value: 1.84e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 169 FDIQAADVIQTdfLKGAEPLQRVVRISGNGRLMATGGTDGKLRVWTFPQMTLAAELAAHSKEIDDLDFSPDSKLIASISK 248
Cdd:COG2319 231 WDLATGKLLRT--LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD 308

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 249 DAQGLVWDLASGQLQHKLQWKTpegakylfkrcrygtveaqkdnYRLFTIA-NPLGK---VGKQRGFLQHWDCASGQLRQ 324
Cdd:COG2319 309 DGTVRLWDLATGKLLRTLTGHT----------------------GAVRSVAfSPDGKtlaSGSDDGTVRLWDLATGELLR 366

                       170       180
                ....*....|....*....|....
gi 24582141 325 A-VAIDESLSSLAVRDDGRFVAVG 347
Cdd:COG2319 367 TlTGHTGAVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
169-259 3.91e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.71  E-value: 3.91e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 169 FDIQAADVIQTdfLKGAEPLQRVVRISGNGRLMATGGTDGKLRVWTFPQMTLAAELAAHSKEIDDLDFSPDSKLIASISK 248
Cdd:COG2319 315 WDLATGKLLRT--LTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392

                        90
                ....*....|.
gi 24582141 249 DAQGLVWDLAS 259
Cdd:COG2319 393 DGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 169-266 1.80e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 67.75  E-value: 1.80e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 169 FDIQAADVIQTdfLKGAEplQRV--VRISGNGRLMATGGTDGKLRVWTFPQMTLAAELAAHSKEIDDLDFSPDSKLIASI 246
Cdd:cd00200  78 WDLETGECVRT--LTGHT--SYVssVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASS 153

                        90       100
                ....*....|....*....|
gi 24582141 247 SKDAQGLVWDLASGQLQHKL 266
Cdd:cd00200 154 SQDGTIKLWDLRTGKCVATL 173
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 190-383 3.64e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.59  E-value: 3.64e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 190 RVVRISGNGRLMATGGTDGKLRVWTFPQMTLAAELAAHSKEIDDLDFSPDSKLIASISKDAQGLVWDLASGQLQHKLQWK 269
Cdd:cd00200  55 RDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 270 TpegakylfkrcryGTVEAqkdnyRLFTIANPLGKVGKQRGFLQHWDCASGQL-RQAVAIDESLSSLAVRDDGRFVAVGT 348
Cdd:cd00200 135 T-------------DWVNS-----VAFSPDGTFVASSSQDGTIKLWDLRTGKCvATLTGHTGEVNSVAFSPDGEKLLSSS 196

                       170       180       190
                ....*....|....*....|....*....|....*
gi 24582141 349 MfSGSVSMYiAFSLQRVLHIPHAHSMFVTGLQFLP 383
Cdd:cd00200 197 S-DGTIKLW-DLSTGKCLGTLRGHENGVNSVAFSP 229
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 192-267 1.26e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.89  E-value: 1.26e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24582141 192 VRISGNGRLMATGGTDGKLRVWTFPQMTLAAELAAHSKEIDDLDFSPDSKLIASISKDaqGL--VWDLASGQLQHKLQ 267
Cdd:cd00200 183 VAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED--GTirVWDLRTGECVQTLS 258
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 169-256 2.74e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.95  E-value: 2.74e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 169 FDIQAADVIQTdfLKGAEplQRV--VRISGNGRLMATGGTDGKLRVWTFPQMTLAAELAAHSKEIDDLDFSPDSKLIASI 246
Cdd:cd00200 204 WDLSTGKCLGT--LRGHE--NGVnsVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASG 279

                        90
                ....*....|
gi 24582141 247 SKDAQGLVWD 256
Cdd:cd00200 280 SADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
195-383 3.88e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 3.88e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 195 SGNGRLMATGGTDGKLRVWTFPQMTLAAELAAHSKEIDDLDFSPDSKLIASISKDAQGLVWDLASGQLQHKLQWKTPEGA 274
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582141 275 KYLFKRCRYGTVEAQKDnyrlftianplgkvgkqrGFLQHWDCASGQ-LRQAVAIDESLSSLAVRDDGRFVAVGTmFSGS 353
Cdd:COG2319  83 SVAFSPDGRLLASASAD------------------GTVRLWDLATGLlLRTLTGHTGAVRSVAFSPDGKTLASGS-ADGT 143

                       170       180       190
                ....*....|....*....|....*....|
gi 24582141 354 VSMYIAFSlQRVLHIPHAHSMFVTGLQFLP 383
Cdd:COG2319 144 VRLWDLAT-GKLLRTLTGHSGAVTSVAFSP 172
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 222-256 5.48e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 5.48e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 24582141    222 AELAAHSKEIDDLDFSPDSKLIASISKDAQGLVWD 256
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
218-256 4.03e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 4.03e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 24582141   218 MTLAAELAAHSKEIDDLDFSPDSKLIASISKDAQGLVWD 256
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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