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Conserved domains on  [gi|24582127|ref|NP_608989|]
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F-box and WD repeat domain containing 5 [Drosophila melanogaster]

Protein Classification

F-box/WD repeat-containing protein( domain architecture ID 15979319)

F-box/WD repeat-containing protein functions as the substrate-recognition component of an SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligase that is involved in ubiquitin-dependent degradation

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
F-box-like pfam12937
F-box-like; This is an F-box-like family.
36-80 7.61e-13

F-box-like; This is an F-box-like family.


:

Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 62.89  E-value: 7.61e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 24582127    36 WWALPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWRHKF 80
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
WD40 COG2319
WD40 repeat [General function prediction only];
575-632 8.70e-11

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.16  E-value: 8.70e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24582127 575 EYVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVWR 632
Cdd:COG2319 343 KTLASGSDDGTVRLWDLATGELLRTLTgHTGAVTSVAFSP-DGRTLASGSADGTVRLWD 400
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
126-157 1.98e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


:

Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.98e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 24582127    126 HGHTHQVLHVSFAHNGEMFATCSKDGYVIIWN 157
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
F-box-like pfam12937
F-box-like; This is an F-box-like family.
36-80 7.61e-13

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 62.89  E-value: 7.61e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 24582127    36 WWALPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWRHKF 80
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
36-81 2.21e-12

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 61.86  E-value: 2.21e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 24582127  36 WWALPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWRHKFQ 81
Cdd:cd22132   1 WPLLPDSLLLHIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWKELFY 46
WD40 COG2319
WD40 repeat [General function prediction only];
575-632 8.70e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.16  E-value: 8.70e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24582127 575 EYVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVWR 632
Cdd:COG2319 343 KTLASGSDDGTVRLWDLATGELLRTLTgHTGAVTSVAFSP-DGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
553-637 1.80e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.19  E-value: 1.80e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582127 553 LRAHKAYTPSaecffIFLDVCEEYVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVW 631
Cdd:cd00200 131 LRGHTDWVNS-----VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFSP-DGEKLLSSSSDGTIKLW 204

                ....*.
gi 24582127 632 RSRAKA 637
Cdd:cd00200 205 DLSTGK 210
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
126-157 1.98e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.98e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 24582127    126 HGHTHQVLHVSFAHNGEMFATCSKDGYVIIWN 157
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
126-157 2.24e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 2.24e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 24582127   126 HGHTHQVLHVSFAHNGEMFATCSKDGYVIIWN 157
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
602-631 3.06e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 3.06e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 24582127    602 HSDVVNSVAFNPrDSEMLVTTSDDYTIKVW 631
Cdd:smart00320  11 HTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
FBOX smart00256
A Receptor for Ubiquitination Targets;
39-79 6.89e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 40.50  E-value: 6.89e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 24582127     39 LPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWRHK 79
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
WD40 pfam00400
WD domain, G-beta repeat;
602-631 1.24e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.24e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 24582127   602 HSDVVNSVAFNPrDSEMLVTTSDDYTIKVW 631
Cdd:pfam00400  10 HTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
WD40 COG2319
WD40 repeat [General function prediction only];
127-159 4.82e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.98  E-value: 4.82e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 24582127 127 GHTHQVLHVSFAHNGEMFATCSKDGYVIIWNAQ 159
Cdd:COG2319 202 GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA 234
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
126-158 1.99e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 1.99e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 24582127 126 HGHTHQVLHVSFAHNGEMFATCSKDGYVIIWNA 158
Cdd:cd00200 132 RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164
 
Name Accession Description Interval E-value
F-box-like pfam12937
F-box-like; This is an F-box-like family.
36-80 7.61e-13

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 62.89  E-value: 7.61e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 24582127    36 WWALPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWRHKF 80
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
36-81 2.21e-12

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 61.86  E-value: 2.21e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 24582127  36 WWALPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWRHKFQ 81
Cdd:cd22132   1 WPLLPDSLLLHIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWKELFY 46
WD40 COG2319
WD40 repeat [General function prediction only];
575-632 8.70e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.16  E-value: 8.70e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24582127 575 EYVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVWR 632
Cdd:COG2319 343 KTLASGSDDGTVRLWDLATGELLRTLTgHTGAVTSVAFSP-DGRTLASGSADGTVRLWD 400
F-box_FBXL1 cd22114
F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also ...
36-76 7.39e-10

F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also called S-phase kinase-associated protein 2, cyclin-A/CDK2-associated protein p45, F-box protein Skp2, or p45skp2, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438886  Cd Length: 41  Bit Score: 54.34  E-value: 7.39e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 24582127  36 WWALPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLW 76
Cdd:cd22114   1 WDSLPDELLLGIFSCLCLPDLLKVSQVCKRWYRLASDESLW 41
WD40 COG2319
WD40 repeat [General function prediction only];
575-632 1.25e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.70  E-value: 1.25e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24582127 575 EYVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVWR 632
Cdd:COG2319 133 KTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSP-DGKLLASGSDDGTVRLWD 190
WD40 COG2319
WD40 repeat [General function prediction only];
576-631 2.34e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.92  E-value: 2.34e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 24582127 576 YVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVW 631
Cdd:COG2319 176 LLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSP-DGKLLASGSADGTVRLW 231
WD40 COG2319
WD40 repeat [General function prediction only];
575-631 5.40e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 5.40e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24582127 575 EYVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVW 631
Cdd:COG2319 259 RLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSP-DGKLLASGSDDGTVRLW 315
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
39-78 9.28e-09

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 51.39  E-value: 9.28e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 24582127    39 LPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWRH 78
Cdd:pfam00646   4 LPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
WD40 COG2319
WD40 repeat [General function prediction only];
576-632 9.74e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 9.74e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24582127 576 YVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVWR 632
Cdd:COG2319 218 LLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSP-DGRLLASGSADGTVRLWD 274
WD40 COG2319
WD40 repeat [General function prediction only];
575-632 1.01e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 1.01e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24582127 575 EYVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVWR 632
Cdd:COG2319 301 KLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSP-DGKTLASGSDDGTVRLWD 358
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
553-637 1.80e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.19  E-value: 1.80e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582127 553 LRAHKAYTPSaecffIFLDVCEEYVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVW 631
Cdd:cd00200 131 LRGHTDWVNS-----VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFSP-DGEKLLSSSSDGTIKLW 204

                ....*.
gi 24582127 632 RSRAKA 637
Cdd:cd00200 205 DLSTGK 210
F-box_FBXL12 cd22123
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ...
38-77 2.47e-08

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438895  Cd Length: 42  Bit Score: 50.04  E-value: 2.47e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 24582127  38 ALPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWR 77
Cdd:cd22123   3 QLPENVLLEILSYLPVRDLLRISRVCKRWRRLVYDKTLWR 42
WD40 COG2319
WD40 repeat [General function prediction only];
576-632 4.22e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 4.22e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24582127 576 YVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVWR 632
Cdd:COG2319  92 LLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSP-DGKTLASGSADGTVRLWD 148
F-box_unchar cd22139
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 ...
36-79 2.36e-07

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438911  Cd Length: 45  Bit Score: 47.62  E-value: 2.36e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 24582127  36 WWALPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWRHK 79
Cdd:cd22139   1 WLCLPDELWLHIFSFLSPKDLCQVALVCRRFNRLASDESLWKQI 44
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
39-71 3.68e-07

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 46.67  E-value: 3.68e-07
                        10        20        30
                ....*....|....*....|....*....|...
gi 24582127  39 LPEPALLMIFERLSVPDLLRASRCCVRWHSIAK 71
Cdd:cd09917   3 LPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
538-636 8.22e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.18  E-value: 8.22e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582127 538 IHVIDLMTLKRVGNmLRAHK------AYTPSAECFfifldvceeyvASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVA 610
Cdd:cd00200 159 IKLWDLRTGKCVAT-LTGHTgevnsvAFSPDGEKL-----------LSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVA 226
                        90       100
                ....*....|....*....|....*.
gi 24582127 611 FNPrDSEMLVTTSDDYTIKVWRSRAK 636
Cdd:cd00200 227 FSP-DGYLLASGSEDGTIRVWDLRTG 251
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
575-631 1.25e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.41  E-value: 1.25e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24582127 575 EYVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVW 631
Cdd:cd00200  22 KLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASA-DGTYLASGSSDKTIRLW 78
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
576-632 1.81e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.03  E-value: 1.81e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24582127 576 YVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVWR 632
Cdd:cd00200 233 LLASGSEDGTIRVWDLRTGECVQTLSgHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
126-157 1.98e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.98e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 24582127    126 HGHTHQVLHVSFAHNGEMFATCSKDGYVIIWN 157
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
575-631 7.03e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.10  E-value: 7.03e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24582127 575 EYVASGAEDQHAYLWDRYYGISLAKFK-HSDVVNSVAFNPrDSEMLVTTSDDYTIKVW 631
Cdd:cd00200  64 TYLASGSSDKTIRLWDLETGECVRTLTgHTSYVSSVAFSP-DGRILSSSSRDKTIKVW 120
F-box_FBXO11 cd22091
F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called ...
39-77 9.76e-06

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438863  Cd Length: 45  Bit Score: 42.79  E-value: 9.76e-06
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 24582127  39 LPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWR 77
Cdd:cd22091   4 LPDEVLLKIFSYLLEQDLCRAAQVCKRFNTLANDPELWK 42
F-box_AtSKIP19-like cd22164
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar ...
36-77 1.30e-05

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar proteins; AtSKIP19, also called F-box protein SKIP19, or F-box/LRR-repeat protein 20 (FBL20), is a component of SCF (SPK1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with CUL1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438935 [Multi-domain]  Cd Length: 47  Bit Score: 42.59  E-value: 1.30e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 24582127  36 WWALPEPALLMIFERLSVPDLLR-ASRCCVRWHSIAKDDLLWR 77
Cdd:cd22164   2 WLDLPDDLTASILSRLGAIDILTnAQKVCKLWRRICKDPSMWR 44
F-box_FBXO7 cd22087
F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called ...
38-80 1.79e-05

F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called FBX7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes BIRC2 and DLGAP5. FBXO7 plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. It promotes MFN1 ubiquitination. FBXO7 acts as a cell cycle regulator by enhancing cyclin D/cyclin-dependent kinase 6 (Cdk6) complex formation and stabilizing levels of p27, a cyclin-dependent kinase inhibitor. Mutations in the FBXO7 (PARK15) gene have been implicated in a juvenile form of parkinsonism called parkinsonian pyramidal syndrome (PPS), characterized by Parkinsonian symptoms and pyramidal tract signs. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438859  Cd Length: 45  Bit Score: 42.29  E-value: 1.79e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 24582127  38 ALPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWRHKF 80
Cdd:cd22087   3 ALPPEIKLRILSLLDVRSLLSLSQVCRDLNSATNDQLLWRFLL 45
WD40 pfam00400
WD domain, G-beta repeat;
126-157 2.24e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 2.24e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 24582127   126 HGHTHQVLHVSFAHNGEMFATCSKDGYVIIWN 157
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
F-box_DdgacFF-like cd22148
F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) ...
39-77 2.35e-05

F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) and similar proteins; DdgacFF, also called GTPase activating factor for raC protein FF, is a Rho GTPase-activating protein involved in the signal transduction pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438919  Cd Length: 44  Bit Score: 41.88  E-value: 2.35e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 24582127  39 LPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWR 77
Cdd:cd22148   5 LPEHLALKILSYLSPKELLIASQVSKTWRRLASSNELWK 43
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
38-80 2.46e-05

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 41.91  E-value: 2.46e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 24582127  38 ALPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWRHKF 80
Cdd:cd22147   4 ALPVELSLKILSYLDAKSLCRAAQVSKKWRNLADDDELWKRMC 46
F-box_FBXO6-like cd22168
F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily ...
38-103 2.60e-05

F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily includes FBXO6 and FBXO44. FBXO6, also called FBX6, F-box protein that recognizes sugar chains 2 (FBS2), or F-box/G-domain protein 2 (FBG2), is a substrate-recognition component of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. It is involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins, by recognizing and binding sugar chains on unfolded glycoproteins that are retro-translocated into the cytosol and promoting their ubiquitination and subsequent degradation. FBXO6 can recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. It also recognizes sulfated glycans. FBXO6 is involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. FBXO44, also called FBXO6A, FBX44, or F-box/G-domain protein 3 (FBG3), is a substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It interacts with SKP1 and CUL1. FBXO44 mediates BRCA1 ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438939 [Multi-domain]  Cd Length: 82  Bit Score: 43.04  E-value: 2.60e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24582127  38 ALPEPALLMIFERLSVPDLLRASR-CCVRWHSIAKDDLLWRHKFQEhfKASPSIPLKPGSESWRAEY 103
Cdd:cd22168   6 DLPEDVLLEILSLVPARDLILSCRlVCSRWRDLVDLPTLWKRKCQR--EGFILKDWDGPPKDWKIFY 70
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
602-631 3.06e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 3.06e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 24582127    602 HSDVVNSVAFNPrDSEMLVTTSDDYTIKVW 631
Cdd:smart00320  11 HTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
F-box_FBXL6 cd22119
F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins; FBXL6, also ...
39-77 3.07e-05

F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins; FBXL6, also called F-box and leucine-rich repeat protein 6, or F-box protein FBL6 (FBL6A), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438891  Cd Length: 47  Bit Score: 41.47  E-value: 3.07e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 24582127  39 LPEPALLMIFERL-----SVPDLLRASRCCVRWHSIAKDDLLWR 77
Cdd:cd22119   4 LPPEILVKIFQFAvategAVPLLCRLSRVCRLWREVALDPSLWT 47
F-box_FBXO21 cd22096
F-box domain found in F-box only protein 21 (FBXO21) and similar proteins; FBXO21, also called ...
38-81 4.46e-05

F-box domain found in F-box only protein 21 (FBXO21) and similar proteins; FBXO21, also called FBX21, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It facilitates Lys29-linkage and activation of ASK1 (apoptosis signal-regulating kinase 1) and promotes type I interferon production upon viral infection. It also polyubiquitylates EP300-interacting inhibitor of differentiation 1 (EID1) and is required for the efficient degradation of EID1 in both cycling and quiescent cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438868  Cd Length: 48  Bit Score: 41.14  E-value: 4.46e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 24582127  38 ALPEPALLMIF--ERLSVPDLLRASRCCVRWHSIAKDDLLWRHKFQ 81
Cdd:cd22096   3 ELPDELLEYILcsDNLDHHDIIRLSCTCRRLREVCQSGKVWREKFF 48
FBOX smart00256
A Receptor for Ubiquitination Targets;
39-79 6.89e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 40.50  E-value: 6.89e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 24582127     39 LPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWRHK 79
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box_FBXO3 cd22084
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called ...
39-77 7.41e-05

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438856  Cd Length: 49  Bit Score: 40.71  E-value: 7.41e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 24582127  39 LPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWR 77
Cdd:cd22084   4 LPSDPLLNILSFLDYRDLISCSQVCRRLNQLCSHDPLWK 42
F-box_FBXL4 cd22117
F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also ...
38-78 1.06e-04

F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438889  Cd Length: 47  Bit Score: 39.91  E-value: 1.06e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 24582127  38 ALPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWRH 78
Cdd:cd22117   3 LLPYELIQLILSYLDLPSLCRLSQTCKLFRKHCYDPLLWKE 43
F-box_FBXW4 cd20090
F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, ...
37-77 1.12e-04

F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, also called dactylin, or F-box and WD-40 domain-containing protein 4, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is likely to be involved in key signaling pathways crucial for normal limb development. It may participate in Wnt signaling and act as a novel tumor suppressor that regulates important cellular processes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438853  Cd Length: 47  Bit Score: 39.89  E-value: 1.12e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 24582127  37 WALPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWR 77
Cdd:cd20090   3 LDLPDDLLFLIFSYLDPASLGRLSQVCRRLYRLISRDAVWR 43
F-box_FBXW8 cd22134
F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, ...
38-76 1.13e-04

F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, also called F-box and WD-40 domain-containing protein 8, or F-box only protein 29 (FBXO29), is the substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as GORASP1, IRS1, MAP4K1/HPK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438906  Cd Length: 48  Bit Score: 40.05  E-value: 1.13e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 24582127  38 ALPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLW 76
Cdd:cd22134   6 QLPRELALKIFQYLSVTDLCRCAQVSKSWKSLAEDELLW 44
F-box_DmSKP2-like cd22149
F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and ...
36-77 1.22e-04

F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and similar proteins; DmSKP2 is a Drosophila F-box protein that regulates cell proliferation by targeting Dacapo (Dap) for ubiquitination and proteasome-mediated degradation. It plays a role in maintaining diploidy of mitotic cells during development. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438920  Cd Length: 43  Bit Score: 39.66  E-value: 1.22e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 24582127  36 WWALPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWR 77
Cdd:cd22149   1 FERLSDEIILSIFKWLPKKTLARCARVCRRWKRLCFDESLWR 42
WD40 pfam00400
WD domain, G-beta repeat;
602-631 1.24e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.24e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 24582127   602 HSDVVNSVAFNPrDSEMLVTTSDDYTIKVW 631
Cdd:pfam00400  10 HTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
F-box_FBXO48 cd22113
F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called ...
40-79 1.43e-04

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438885  Cd Length: 46  Bit Score: 39.61  E-value: 1.43e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 24582127  40 PEPALLmIFERLSVPDLLRASRCCVRWHSIAKD-DLLWRHK 79
Cdd:cd22113   6 PEMSLR-IFSQLDVQSLCRASQTCKTWNDLIENsDYLWRPH 45
F-box_FBXW12 cd22137
F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; ...
39-77 1.88e-04

F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; FBXW12, also called F-box and WD-40 domain-containing protein 12, or F-box only protein 35 (FBXO35), is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It functions as an epithelial growth suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438909  Cd Length: 44  Bit Score: 39.28  E-value: 1.88e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 24582127  39 LPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWR 77
Cdd:cd22137   3 LPDLPMLRIFSFLDAFSLLQAAQVNKQWNKVADSDYLWR 41
F-box_FBXL5 cd22118
F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also ...
39-76 2.24e-04

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438890  Cd Length: 41  Bit Score: 38.86  E-value: 2.24e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 24582127  39 LPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLW 76
Cdd:cd22118   4 LPPEIMLKIFSYLNPQDLCRCAQVCTKWSQLARDGSLW 41
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
39-77 2.45e-04

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 38.84  E-value: 2.45e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 24582127  39 LPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWR 77
Cdd:cd22151   3 LPDDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLWE 41
F-box_FBXO41 cd22109
F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called ...
43-77 4.23e-04

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438881  Cd Length: 47  Bit Score: 38.46  E-value: 4.23e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 24582127  43 ALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWR 77
Cdd:cd22109  10 ALFCVFSYLDTKSLLRCAEVCREWRDVSRHPALWQ 44
F-box_FBXL7 cd22120
F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also ...
39-77 4.40e-04

F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also called F-box and leucine-rich repeat protein 7, or F-box protein FBL6/FBL7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of Aurora kinase A (AURKA) during mitosis, causing mitotic arrest. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438892  Cd Length: 44  Bit Score: 38.13  E-value: 4.40e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 24582127  39 LPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWR 77
Cdd:cd22120   4 LPDDVILQIFSHLPTNQLCRCARVCRRWYNLAWDPRLWT 42
F-box_FBXO36 cd22106
F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called ...
39-81 4.50e-04

F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called FBX36, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438878  Cd Length: 46  Bit Score: 38.33  E-value: 4.50e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 24582127  39 LPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWRHKFQ 81
Cdd:cd22106   4 LPDKLLLYIISYLDLEDIARLSQTSKRFKKLCNSDELWEKIYM 46
WD40 COG2319
WD40 repeat [General function prediction only];
127-159 4.82e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.98  E-value: 4.82e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 24582127 127 GHTHQVLHVSFAHNGEMFATCSKDGYVIIWNAQ 159
Cdd:COG2319 202 GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA 234
WD40 COG2319
WD40 repeat [General function prediction only];
126-159 8.47e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 8.47e-04
                        10        20        30
                ....*....|....*....|....*....|....
gi 24582127 126 HGHTHQVLHVSFAHNGEMFATCSKDGYVIIWNAQ 159
Cdd:COG2319 243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276
F-box_FBXO45 cd22111
F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called ...
36-68 1.05e-03

F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called FBX45, or F-box/SPRY domain-containing protein 1, functions as the substrate-recognition component of E3 ubiquitin ligase complexes. It is critical for synaptogenesis, neuronal migration, and synaptic transmission. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438883  Cd Length: 36  Bit Score: 36.88  E-value: 1.05e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 24582127  36 WWALPEPALLMIFERLSVPDLLRASRCCVRWHS 68
Cdd:cd22111   1 AARLPSRVLEVIFSYLDLPDLRNCSLVCKSWYR 33
F-box_AtSKIP5-like cd22163
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 5 (AtSKIP5) and similar ...
44-76 1.88e-03

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 5 (AtSKIP5) and similar proteins; AtSKIP5, also called F-box protein SKIP5, is a component of SCF (SKP1-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438934  Cd Length: 46  Bit Score: 36.56  E-value: 1.88e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 24582127  44 LLMIFERLS-VPDLLRASRCCVRWHSIAKDDLLW 76
Cdd:cd22163   9 LMHIFSFLTpLPDRFNAARVCKRWRALALDPRSW 42
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
126-158 1.99e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 1.99e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 24582127 126 HGHTHQVLHVSFAHNGEMFATCSKDGYVIIWNA 158
Cdd:cd00200 132 RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164
F-box_AtSKIP22-like cd22165
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 22 (AtSKIP22) and similar ...
38-80 2.20e-03

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 22 (AtSKIP22) and similar proteins; AtSKIP22, also called F-box protein SKIP22, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438936  Cd Length: 46  Bit Score: 36.48  E-value: 2.20e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 24582127  38 ALPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWRHKF 80
Cdd:cd22165   4 RLPTELKLKILELLPGVDLARMACVCSELRFLASNDDLWKQKF 46
F-box_FBXO13 cd22092
F-box domain found in F-box only protein 13 (FBXO13) and similar proteins; FBXO13, also called ...
37-77 2.34e-03

F-box domain found in F-box only protein 13 (FBXO13) and similar proteins; FBXO13, also called FBX13, F-box/LRR-repeat protein 17 (FBL17), or F-box and leucine-rich repeat protein 17 (FBXL17), is the substrate-recognition component of SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438864  Cd Length: 49  Bit Score: 36.24  E-value: 2.34e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 24582127  37 WALPEPALLMIFERLSVPD-LLRASRCCVRWHSIAKDDLLWR 77
Cdd:cd22092   3 NQLPDSILLKIFSYLSLQErCLSASLVCKYWRDLCLDSQFWK 44
F-box_FBXO18 cd22095
F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called ...
39-74 2.60e-03

F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called FBX18, or F-box DNA helicase 1 (FBH1), is a 3'-5' DNA helicase and the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438867  Cd Length: 48  Bit Score: 36.10  E-value: 2.60e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 24582127  39 LPEPALLMIFERLSVPDLLR-ASRCCVRWHSIAKDDL 74
Cdd:cd22095   5 LPEELLRNIFAFLPAEDLYQnISLVCRHWRDIVSDPL 41
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
126-157 2.79e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.01  E-value: 2.79e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 24582127 126 HGHTHQVLHVSFAHNGEMFATCSKDGYVIIWN 157
Cdd:cd00200  90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
602-632 2.91e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.01  E-value: 2.91e-03
                        10        20        30
                ....*....|....*....|....*....|.
gi 24582127 602 HSDVVNSVAFNPrDSEMLVTTSDDYTIKVWR 632
Cdd:cd00200   8 HTGGVTCVAFSP-DGKLLATGSGDGTIKVWD 37
F-box_FBXW7 cd22133
F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, ...
39-77 3.13e-03

F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438905  Cd Length: 59  Bit Score: 36.25  E-value: 3.13e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 24582127  39 LPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWR 77
Cdd:cd22133  21 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 59
WD40 COG2319
WD40 repeat [General function prediction only];
126-159 3.26e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.28  E-value: 3.26e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 24582127 126 HGHTHQVLHVSFAHNGEMFATCSKDGYVIIWNAQ 159
Cdd:COG2319 159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA 192
F-box_FBXL13 cd22124
F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also ...
39-76 3.44e-03

F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also called F-box and leucine-rich repeat protein 13, or dynein regulatory complex subunit 6, is a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. It is also the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438896  Cd Length: 42  Bit Score: 35.77  E-value: 3.44e-03
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 24582127  39 LPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLW 76
Cdd:cd22124   4 LPRKAALKIFSYLDLRDLARCAQVCRSWKVITQSSSLW 41
WD40 COG2319
WD40 repeat [General function prediction only];
127-159 4.37e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.89  E-value: 4.37e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 24582127 127 GHTHQVLHVSFAHNGEMFATCSKDGYVIIWNAQ 159
Cdd:COG2319 370 GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
126-159 6.03e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.51  E-value: 6.03e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 24582127 126 HGHTHQVLHVSFAHNGEMFATCSKDGYVIIWNAQ 159
Cdd:COG2319 285 TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318
F-box_ScMFB1-like cd22146
F-box domain found in Saccharomyces cerevisiae mitochondrial F-box protein MFB1 (ScMFB1) and ...
39-77 6.19e-03

F-box domain found in Saccharomyces cerevisiae mitochondrial F-box protein MFB1 (ScMFB1) and similar proteins; ScMFB1 is a novel mitochondria-associated F-box protein that functions to increase mitochondrial connectivity in yeast. ScMFB1 acts as a key component of a Skp1-Cdc53/Cullin-F-box protein (SCF) ubiquitin ligase complex machinery that regulates mitochondrial dynamics throughout the yeast's entire life cycle. It interacts with Skp1p in an F-box-dependent manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438917  Cd Length: 42  Bit Score: 34.92  E-value: 6.19e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 24582127  39 LPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWR 77
Cdd:cd22146   4 LPLEILFEILIYLDIPDILNLSKTCRFLYVLLNDEILWR 42
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
122-159 7.05e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 38.86  E-value: 7.05e-03
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 24582127 122 VENNHGHTHQVLHVSFAHNGEMFATCSKDGYVIIWNAQ 159
Cdd:cd00200 170 VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207
WD40 COG2319
WD40 repeat [General function prediction only];
126-159 7.49e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.12  E-value: 7.49e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 24582127 126 HGHTHQVLHVSFAHNGEMFATCSKDGYVIIWNAQ 159
Cdd:COG2319 117 TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA 150
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
126-157 8.05e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 38.86  E-value: 8.05e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 24582127 126 HGHTHQVLHVSFAHNGEMFATCSKDGYVIIWN 157
Cdd:cd00200 216 RGHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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