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Conserved domains on  [gi|19920764|ref|NP_608938|]
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oscillin, isoform A [Drosophila melanogaster]

Protein Classification

sugar phosphate isomerase family( domain architecture ID 368)

sugar phosphate isomerase family

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SugarP_isomerase super family cl00339
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
1-253 3.69e-157

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


The actual alignment was detected with superfamily member PTZ00285:

Pssm-ID: 469729  Cd Length: 253  Bit Score: 437.27  E-value: 3.69e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764    1 MRLVILETSDSVGKWAAKYVMKRINDFQPSADRYFVLGLPTGSTPLGMYKELIEFHKQGKVSFQYVKTFNMDEYVGLARD 80
Cdd:PTZ00285   1 MRIVISEDADAVADYTSNYIIKRINDFKPTSDRPFVLGLPTGSTPLPTYQELIRAYREGRVSFSNVVTFNMDEYVGLPRD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764   81 HHESYHYFMWNNFFKHIDIEPKNVHILDGNAADLVAECNKFEDQIREAGGVELFIGGIGPDGHIAFNEPGSSLVSRTRVK 160
Cdd:PTZ00285  81 HPQSYHYFMKENFFDHVDIKEENRHILNGTAPDLEEECRRYEEKIRAVGGIDLFLAGIGTDGHIAFNEPGSSLDSRTRVK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764  161 TLAQDTLEANARFFDNDMSKVPKQALTVGVGTVMDSKEVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHANTLMICD 240
Cdd:PTZ00285 161 SLNQETIDANARFFGNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQMHPAAVLCLD 240
                        250
                 ....*....|...
gi 19920764  241 EDATLELRVKTVK 253
Cdd:PTZ00285 241 EDATLELKVKTTK 253
 
Name Accession Description Interval E-value
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
1-253 3.69e-157

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 437.27  E-value: 3.69e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764    1 MRLVILETSDSVGKWAAKYVMKRINDFQPSADRYFVLGLPTGSTPLGMYKELIEFHKQGKVSFQYVKTFNMDEYVGLARD 80
Cdd:PTZ00285   1 MRIVISEDADAVADYTSNYIIKRINDFKPTSDRPFVLGLPTGSTPLPTYQELIRAYREGRVSFSNVVTFNMDEYVGLPRD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764   81 HHESYHYFMWNNFFKHIDIEPKNVHILDGNAADLVAECNKFEDQIREAGGVELFIGGIGPDGHIAFNEPGSSLVSRTRVK 160
Cdd:PTZ00285  81 HPQSYHYFMKENFFDHVDIKEENRHILNGTAPDLEEECRRYEEKIRAVGGIDLFLAGIGTDGHIAFNEPGSSLDSRTRVK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764  161 TLAQDTLEANARFFDNDMSKVPKQALTVGVGTVMDSKEVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHANTLMICD 240
Cdd:PTZ00285 161 SLNQETIDANARFFGNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQMHPAAVLCLD 240
                        250
                 ....*....|...
gi 19920764  241 EDATLELRVKTVK 253
Cdd:PTZ00285 241 EDATLELKVKTTK 253
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
1-258 7.53e-147

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 411.51  E-value: 7.53e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764     1 MRLVILETSDSVGKWAAKYVMKRINDFQPSADRYFVLGLPTGSTPLGMYKELIEFHKQGKVSFQYVKTFNMDEYVGLARD 80
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPTAARPFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764    81 HHESYHYFMWNNFFKHIDIEPKNVHILDGNAADLVAECNKFEDQIREAGGVELFIGGIGPDGHIAFNEPGSSLVSRTRVK 160
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764   161 TLAQDTLEANARFFDNDMSKVPKQALTVGVGTVMDSKEVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHANTLMICD 240
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240
                         250
                  ....*....|....*...
gi 19920764   241 EDATLELRVKTVKYFKGI 258
Cdd:TIGR00502 241 ENATQELKVKTVEYFNEL 258
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
10-247 5.74e-138

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 388.00  E-value: 5.74e-138
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764  10 DSVGKWAAKYVMKRINDFqpsadRYFVLGLPTGSTPLGMYKELIEFHKQGKVSFQYVKTFNMDEYVGLARDHHESYHYFM 89
Cdd:cd01399   1 EEMSEAAAELIAELIREK-----PPAVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFM 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764  90 WNNFFKHIDIEPKNVHILDGNAADLVAECNKFEDQIREAGGVELFIGGIGPDGHIAFNEPGSSLVSRTRVKTLAQDTLEA 169
Cdd:cd01399  76 RENLFDHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQA 155
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19920764 170 NARFFDNDmSKVPKQALTVGVGTVMDSKEVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHANTLMICDEDATLEL 247
Cdd:cd01399 156 NARFFDGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
1-247 2.07e-114

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 329.04  E-value: 2.07e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764   1 MRLVILETSDSVGKWAAKYVMKRINDFQpSADRYFVLGLPTGSTPLGMYKELIEFHKQGKVSFQYVKTFNMDEYVGLARD 80
Cdd:COG0363   2 MRVIIFPDAEELAAAAAERAAERIAEAI-AEKGRAVLGLAGGSTPLGLYEELARLHKEGGLDWSRVHVFNLDEYVGLPPD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764  81 HHESYHYFMWNNFFKHIDIEPKNVHILDGNAADLVAECNKFEDQIREAGGVELFIGGIGPDGHIAFNEPGSSLVSRT-RV 159
Cdd:COG0363  81 HPQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGSPFLSETdRV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764 160 KTLAQDTLEANARFFDNdMSKVPKQALTVGVGTVMDSKEVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHANTLMIC 239
Cdd:COG0363 161 VTLDESTRQANARFFGS-IPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNVTWFL 239

                ....*...
gi 19920764 240 DEDATLEL 247
Cdd:COG0363 240 DEAAASLL 247
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
7-237 2.01e-18

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 81.51  E-value: 2.01e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764     7 ETSDSVGKWAAKYVMKRINDFQpSADRYFVLGLPTGSTPLGMYKELIEFHKQ---GKVSFQYVktfnmDE-YVglARDHH 82
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAAL-AERGRFTLALSGGSTPKPLYELLAAAPARldwSRVHVFWG-----DErCV--PPDDP 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764    83 ESYHYFMWNNFFKHIDIEPKNVHILDGNAADLVAECNKFEDQIREA-GGVELFIG-----GIGPDGHIA--FnePGSSLV 154
Cdd:pfam01182  73 DSNYGMAREALLSHVPIPASNVHPIPASAADPEEAAAAYEAELRELlPDLELPVFdlvllGMGPDGHTAslF--PGSPAL 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764   155 SRTRVKTLAQdtleanarffdNDMSKVPKQALTVGVGTVMDSKEVMILITGAHKAFALYKAIEEGVnHMWTVSAFQQHAN 234
Cdd:pfam01182 151 EETDRLVVAV-----------TDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAGDP-DPLPAALVRPGAG 218

                  ...
gi 19920764   235 TLM 237
Cdd:pfam01182 219 ETV 221
 
Name Accession Description Interval E-value
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
1-253 3.69e-157

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 437.27  E-value: 3.69e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764    1 MRLVILETSDSVGKWAAKYVMKRINDFQPSADRYFVLGLPTGSTPLGMYKELIEFHKQGKVSFQYVKTFNMDEYVGLARD 80
Cdd:PTZ00285   1 MRIVISEDADAVADYTSNYIIKRINDFKPTSDRPFVLGLPTGSTPLPTYQELIRAYREGRVSFSNVVTFNMDEYVGLPRD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764   81 HHESYHYFMWNNFFKHIDIEPKNVHILDGNAADLVAECNKFEDQIREAGGVELFIGGIGPDGHIAFNEPGSSLVSRTRVK 160
Cdd:PTZ00285  81 HPQSYHYFMKENFFDHVDIKEENRHILNGTAPDLEEECRRYEEKIRAVGGIDLFLAGIGTDGHIAFNEPGSSLDSRTRVK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764  161 TLAQDTLEANARFFDNDMSKVPKQALTVGVGTVMDSKEVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHANTLMICD 240
Cdd:PTZ00285 161 SLNQETIDANARFFGNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQMHPAAVLCLD 240
                        250
                 ....*....|...
gi 19920764  241 EDATLELRVKTVK 253
Cdd:PTZ00285 241 EDATLELKVKTTK 253
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
1-261 6.96e-154

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 429.25  E-value: 6.96e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764    1 MRLVILETSDSVGKWAAKYVMKRINDFQPSADRYFVLGLPTGSTPLGMYKELIEFHKQGKVSFQYVKTFNMDEYVGLARD 80
Cdd:PRK00443   1 MRLIILKTAEEVGKWAARHIANRINAFLPTKERPFVLGLATGSSPLETYKALIELHKAGKVDFSRVTTFNLDEYVGLPAD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764   81 HHESYHYFMWNNFFKHIDIEPKNVHILDGNAADLVAECNKFEDQIREAGGVELFIGGIGPDGHIAFNEPGSSLVSRTRVK 160
Cdd:PRK00443  81 HPESYRYFMRENFFDHVDIPPENINLLNGNAPDPEAECRRYEEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764  161 TLAQDTLEANARFFDNDMSKVPKQALTVGVGTVMDSKEVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHANTLMICD 240
Cdd:PRK00443 161 TLTEDTRIANSRFFDGDIEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240
                        250       260
                 ....*....|....*....|.
gi 19920764  241 EDATLELRVKTVKYFKGILRD 261
Cdd:PRK00443 241 EAAASELKVKTVKYFTELEAE 261
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
1-258 7.53e-147

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 411.51  E-value: 7.53e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764     1 MRLVILETSDSVGKWAAKYVMKRINDFQPSADRYFVLGLPTGSTPLGMYKELIEFHKQGKVSFQYVKTFNMDEYVGLARD 80
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPTAARPFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764    81 HHESYHYFMWNNFFKHIDIEPKNVHILDGNAADLVAECNKFEDQIREAGGVELFIGGIGPDGHIAFNEPGSSLVSRTRVK 160
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764   161 TLAQDTLEANARFFDNDMSKVPKQALTVGVGTVMDSKEVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHANTLMICD 240
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240
                         250
                  ....*....|....*...
gi 19920764   241 EDATLELRVKTVKYFKGI 258
Cdd:TIGR00502 241 ENATQELKVKTVEYFNEL 258
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
10-247 5.74e-138

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 388.00  E-value: 5.74e-138
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764  10 DSVGKWAAKYVMKRINDFqpsadRYFVLGLPTGSTPLGMYKELIEFHKQGKVSFQYVKTFNMDEYVGLARDHHESYHYFM 89
Cdd:cd01399   1 EEMSEAAAELIAELIREK-----PPAVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFM 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764  90 WNNFFKHIDIEPKNVHILDGNAADLVAECNKFEDQIREAGGVELFIGGIGPDGHIAFNEPGSSLVSRTRVKTLAQDTLEA 169
Cdd:cd01399  76 RENLFDHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQA 155
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19920764 170 NARFFDNDmSKVPKQALTVGVGTVMDSKEVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHANTLMICDEDATLEL 247
Cdd:cd01399 156 NARFFDGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
1-247 2.07e-114

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 329.04  E-value: 2.07e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764   1 MRLVILETSDSVGKWAAKYVMKRINDFQpSADRYFVLGLPTGSTPLGMYKELIEFHKQGKVSFQYVKTFNMDEYVGLARD 80
Cdd:COG0363   2 MRVIIFPDAEELAAAAAERAAERIAEAI-AEKGRAVLGLAGGSTPLGLYEELARLHKEGGLDWSRVHVFNLDEYVGLPPD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764  81 HHESYHYFMWNNFFKHIDIEPKNVHILDGNAADLVAECNKFEDQIREAGGVELFIGGIGPDGHIAFNEPGSSLVSRT-RV 159
Cdd:COG0363  81 HPQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGSPFLSETdRV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764 160 KTLAQDTLEANARFFDNdMSKVPKQALTVGVGTVMDSKEVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHANTLMIC 239
Cdd:COG0363 161 VTLDESTRQANARFFGS-IPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNVTWFL 239

                ....*...
gi 19920764 240 DEDATLEL 247
Cdd:COG0363 240 DEAAASLL 247
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
4-251 4.09e-73

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 235.69  E-value: 4.09e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764    4 VILETSDSVGKWAAKYVMKRINDFQpSADRYFVLGLPTGSTPLGMYKELIEFHKQGKVSFQYVKTFNMDEYVGLARDHHE 83
Cdd:PRK02122  31 DIFESSEEASRAVAQEIATLIRERQ-AEGKPCVLGLATGSSPIGVYAELIRMHREEGLSFKNVITFNLDEYYPMQPDSLQ 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764   84 SYHYFMWNNFFKHIDIEPKNVHILDG--NAADLVAECNKFEDQIREAGGVELFIGGIGPDGHIAFNEPGSSLVSRTRVKT 161
Cdd:PRK02122 110 SYHRFMKENLFDHVDIPPENIHIPDGtiPKEEIDEYCRDYEEKIEAAGGIDFQLLGIGRTGHIGFNEPGSGRNSRTRLVT 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764  162 LAQDTLEANARFFdNDMSKVPKQALTVGVGTVMDSKEVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHANTLMICDE 241
Cdd:PRK02122 190 LDHITRRDAASDF-FGEENVPRKAITMGVGTILKARRIVLLAWGEHKAPIIKRAVEGEISDEVPASYLQEHPNATFVLDL 268
                        250
                 ....*....|.
gi 19920764  242 DATLEL-RVKT 251
Cdd:PRK02122 269 AAASELtRIKT 279
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
13-239 4.65e-36

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 126.70  E-value: 4.65e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764  13 GKWAAKYVMKRINDFqPSADRYFVLGLPTGSTPLGMYKELIEFHKQGkvSFQYVKTFNMDEYVGLArDHHESYHYFMWNN 92
Cdd:cd00458   1 AKEALKFIEDK*EKL-LEEKDDMVIGLGTGSTPAYFYKLLGEKLKRG--EISDIVGFPTDERYVPL-DSDQSNFRQAKLL 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764  93 FFKHIDIEPKNVHILDGNAADLVAECNKFEDQIREAGGVELFIGGIGpdghiafnepgsslvsrtrvktlaqdtleanar 172
Cdd:cd00458  77 AFEHDIIPASNVHYVDTSLPIEKACEKYEREILDQVDAIDLAVDGAG--------------------------------- 123
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19920764 173 ffdndmskvpkqaltvgvgtvMDSKEVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHANTLMIC 239
Cdd:cd00458 124 ---------------------YRAGTVIVLVDGRKKVDYLCQNTEPGVIENGIFADIRGKEKDIVIV 169
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
1-247 1.78e-29

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 111.38  E-value: 1.78e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764    1 MRLVILETSDSVGKWAAKYVMKRIndfqpSADRYFVLGLPTGSTPLGMYKELIEFHKqGKVSFQYVKTFNMDEyvgLARD 80
Cdd:PRK12358   1 MKIIITKDYEEMSRVAAHHLLGYM-----SKTKRVNLAITAGSTPKGMYEYLITLVK-GKAWYDNVHYYNFDE---IPFR 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764   81 HHESYHYFMWN---NFFKHIDIEPKNVHILDgnaadlVAECNKFEDQIREAGGVELFIGGIGPDGHIAFNEPG-SSLVSR 156
Cdd:PRK12358  72 GKEGEGVTITNlrnLFFTPAGIKEENIHKLT------IDNYREHDQKLARDGGLDLVVLGLGADGHFCGNLPGtTHFHDE 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764  157 TRVKTLAQDTLEANARFFDN-DMSKVPKQALTVGVGTVMDSKEVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHANT 235
Cdd:PRK12358 146 TVEVPIQGEMVDIVAHGELGgDFSLVPDSYVTMGPKSIMAAKNLLLIVNGKGKAQILKKVLQGPVTEDVPASILQLHPNL 225
                        250
                 ....*....|..
gi 19920764  236 LMICDEDATLEL 247
Cdd:PRK12358 226 TVILDEAAAAEL 237
PRK09762 PRK09762
galactosamine-6-phosphate isomerase; Provisional
1-240 3.81e-29

galactosamine-6-phosphate isomerase; Provisional


Pssm-ID: 182064  Cd Length: 232  Bit Score: 110.30  E-value: 3.81e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764    1 MRLVILETSDSVGKWAAKYVMKRINDfQPSAdryfVLGLPTGSTPLGMYKELIEFHKQGKVSFQYVKTFNMDEYVGLARD 80
Cdd:PRK09762   1 QTLQQVENYTALSERASEYLLAVIRS-KPDA----VICLATGATPLLTYHYLVEKIHQQQVDVSQLTFVKLDEWVDLPLT 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764   81 HHESYHYFMWNNFFKHIDIEPKNVHILDGNAADlVAECNKFEDQIREAGGVELFIGGIGPDGHIAFNEPGSSLVSRTRVK 160
Cdd:PRK09762  76 MPGTCETFLQQHIVQPLGLREDQLISFRSEEIN-ETECERVTNLIARKGGLDLCVLGLGKNGHLGLNEPGESLQPACHIS 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764  161 TLAQDTLEANARFFDNdmsKVPKQALTVGVGTVMDSKEVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHANTL-MIC 239
Cdd:PRK09762 155 QLDARTQQHEMLKTAG---RPVTRGITLGLKDILNAREVLLLVTGEGKQDATERFLTAKVSTAIPASFLWLHSNFIcLID 231

                 .
gi 19920764  240 D 240
Cdd:PRK09762 232 R 232
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
7-237 2.01e-18

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 81.51  E-value: 2.01e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764     7 ETSDSVGKWAAKYVMKRINDFQpSADRYFVLGLPTGSTPLGMYKELIEFHKQ---GKVSFQYVktfnmDE-YVglARDHH 82
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAAL-AERGRFTLALSGGSTPKPLYELLAAAPARldwSRVHVFWG-----DErCV--PPDDP 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764    83 ESYHYFMWNNFFKHIDIEPKNVHILDGNAADLVAECNKFEDQIREA-GGVELFIG-----GIGPDGHIA--FnePGSSLV 154
Cdd:pfam01182  73 DSNYGMAREALLSHVPIPASNVHPIPASAADPEEAAAAYEAELRELlPDLELPVFdlvllGMGPDGHTAslF--PGSPAL 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764   155 SRTRVKTLAQdtleanarffdNDMSKVPKQALTVGVGTVMDSKEVMILITGAHKAFALYKAIEEGVnHMWTVSAFQQHAN 234
Cdd:pfam01182 151 EETDRLVVAV-----------TDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAGDP-DPLPAALVRPGAG 218

                  ...
gi 19920764   235 TLM 237
Cdd:pfam01182 219 ETV 221
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
16-236 3.35e-17

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 77.99  E-value: 3.35e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764  16 AAKYVMKRINDFQpSADRYFVLGLPTGSTPLGMYKEL-----IEFHKqgkVSFQYVktfnmDE-YVglARDHHESYHYFM 89
Cdd:cd01400   7 LADRIAEALAAAI-AKRGRFSLALSGGSTPKPLYELLaaapaLDWSK---VHVFLG-----DErCV--PPDDPDSNYRLA 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764  90 WNNFFKHIDIEPKNVH-ILDGNAADLVAEcnKFEDQIREA-GGVELF---IGGIGPDGHIA--FnePGSSLVSRTRVKTL 162
Cdd:cd01400  76 REALLSHVAIPAANIHpIPTELGPEDAAA--AYEKELRALfGGVPPFdlvLLGMGPDGHTAslF--PGHPALLEETDRLV 151
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19920764 163 AqdtleanarfFDNDMSKVPKQALTVGVGTVMDSKEVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHANTL 236
Cdd:cd01400 152 V----------AVTDSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEALKRALAGPDPEELPAARVLPRPGEV 215
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
5-247 3.43e-14

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 70.10  E-value: 3.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764     5 ILETSDSVGKWAAKYVMKRINDFQPSADRyFVLGLPTGSTPLGMYKEL----IEFHKQGkVSF---QYVKTFNMDEYVGL 77
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQ-FSLALSGGRSPIALLEALaaqpLDWSRIH-LFLgdeRYVPLDHADSNTGL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764    78 ARDHhesyhyfmwnnFFKHIDIEPKNVHILDGNAADLVAECNKFEDQIREA------GGVELFIGGIGPDGHIAFNEPGS 151
Cdd:TIGR01198  79 AREA-----------LLDRVAIPASNIHPMPTELSDIEEAAELYEQELAAAfqpivfPVFDLLLLGMGPDGHTASLFPHT 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764   152 SLVsRTRVKTLAqdtleanarfFDNDMSKVPKQALTVGVGTVMDSKEVMILITGAHKAFALYKAIE-EGVNHMWTVSAFQ 230
Cdd:TIGR01198 148 PAL-QETERLVT----------VLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAvEAEPYPLPAAGVL 216
                         250
                  ....*....|....*..
gi 19920764   231 QHANTLMICDEDATLEL 247
Cdd:TIGR01198 217 HSGKTLWLLDYAAARKL 233
PLN02360 PLN02360
probable 6-phosphogluconolactonase
5-219 1.49e-06

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 48.32  E-value: 1.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764    5 ILETSDSVGKWAAKYVmKRINDFQPSADRYFVLGLPTGSTpLGMYKELIE--FHKQGKVSFQYVktFNMDEYVgLARDHH 82
Cdd:PLN02360  15 VHENLDELSTDLAEYI-AELSEASVKERGVFAIALSGGSL-ISFMGKLCEapYNKTVDWAKWYI--FWADERV-VAKNHA 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920764   83 ESYHYFMWNNFFKHIDIEPKNVHILDGNAAdlvAE--CNKFEDQIREAGGV--------------ELFIGGIGPDGHIAF 146
Cdd:PLN02360  90 DSNYKLAKDGLLSKVPVVPSHVYSINDTVT---AEeaATDYEFAIRQLVKTrtigvsdisdcpkfDLILLGMGSDGHVAS 166
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19920764  147 NEPGSSLvsrtrvktlaqdtLEANARF--FDNDMSKVPKQALTVGVGTVMDSKEVMILITGAHKAFALYKAIEEG 219
Cdd:PLN02360 167 LFPNHPA-------------LEEKDDWvtFITDSPKPPPERITFTLPVINSASNVAVVATGESKANAVHLAIDDV 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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