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Conserved domains on  [gi|19920690|ref|NP_608841|]
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FIG4 phosphoinositide 5-phosphatase [Drosophila melanogaster]

Protein Classification

SAC family polyphosphoinositide phosphatase( domain architecture ID 10493136)

SAC family polyphosphoinositide phosphatase catalyzes the hydrolysis of phosphatidylinositol (PtdIns) phosphates, such as PtdIns(3)P, PtdIns(4)P, and/or PtdIns(3,5)P2

EC:  3.1.3.-
Gene Ontology:  GO:0046856|GO:0052866
PubMed:  10947947

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Syja_N pfam02383
SacI homology domain; This Pfam family represents a protein domain which shows homology to the ...
85-407 7.27e-107

SacI homology domain; This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.


:

Pssm-ID: 460545  Cd Length: 295  Bit Score: 330.69  E-value: 7.27e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690    85 YGVLGFVRFLEGYYLLLVTKRKCCAHIGRHLVYTIKDTVMVRVN----EVTSQRPPHPHEDRYKRMFQNIDLRSNFYFSY 160
Cdd:pfam02383   1 YGILGLIRLLSGYYLIVITKREQVGQIGGHPIYKITDVEFIPLNsslsDTQLAKKEHPDEERLLKLLKLFLSSGSFYFSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690   161 SYDLTRTLQYNESAPRYvgakvdldrdeplPDWNTLTsnvdkahervdyafrsdsrKRFVWNAYLLQPMEGIMLK--DWL 238
Cdd:pfam02383  81 DYDLTNSLQRNLTRSRS-------------PSFDSLD-------------------DRFFWNRHLLKPLIDFQLDldRWI 128
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690   239 LEVTHGFVSQSCISIFGRHVNVCLVARRSSRFAGTRFLKRGANFQGDVANEVETEQIVSD-----GQRICAFTQMRGSIP 313
Cdd:pfam02383 129 LPLIQGFVEQGKLSVFGRSVTLTLISRRSRKRAGTRYLRRGIDDDGNVANFVETEQIVSLntsnsEGKIFSFVQIRGSIP 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690   314 SHWSQDISKMVpKPQIQLDICDPYAQTPSLHFERLLFHYGaPLIMLNLVkkrERRKHESIISKELEYSIRYLNQFLppPH 393
Cdd:pfam02383 209 LFWSQDPNLKY-KPKIQITRPEATQPAFKKHFDDLIERYG-PVHIVNLV---EKKGRESKLSEAYEEAVKYLNQFL--PD 281
                         330
                  ....*....|....
gi 19920690   394 RMKHIHFDMARQSR 407
Cdd:pfam02383 282 KLRYTAFDFHHECK 295
 
Name Accession Description Interval E-value
Syja_N pfam02383
SacI homology domain; This Pfam family represents a protein domain which shows homology to the ...
85-407 7.27e-107

SacI homology domain; This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.


Pssm-ID: 460545  Cd Length: 295  Bit Score: 330.69  E-value: 7.27e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690    85 YGVLGFVRFLEGYYLLLVTKRKCCAHIGRHLVYTIKDTVMVRVN----EVTSQRPPHPHEDRYKRMFQNIDLRSNFYFSY 160
Cdd:pfam02383   1 YGILGLIRLLSGYYLIVITKREQVGQIGGHPIYKITDVEFIPLNsslsDTQLAKKEHPDEERLLKLLKLFLSSGSFYFSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690   161 SYDLTRTLQYNESAPRYvgakvdldrdeplPDWNTLTsnvdkahervdyafrsdsrKRFVWNAYLLQPMEGIMLK--DWL 238
Cdd:pfam02383  81 DYDLTNSLQRNLTRSRS-------------PSFDSLD-------------------DRFFWNRHLLKPLIDFQLDldRWI 128
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690   239 LEVTHGFVSQSCISIFGRHVNVCLVARRSSRFAGTRFLKRGANFQGDVANEVETEQIVSD-----GQRICAFTQMRGSIP 313
Cdd:pfam02383 129 LPLIQGFVEQGKLSVFGRSVTLTLISRRSRKRAGTRYLRRGIDDDGNVANFVETEQIVSLntsnsEGKIFSFVQIRGSIP 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690   314 SHWSQDISKMVpKPQIQLDICDPYAQTPSLHFERLLFHYGaPLIMLNLVkkrERRKHESIISKELEYSIRYLNQFLppPH 393
Cdd:pfam02383 209 LFWSQDPNLKY-KPKIQITRPEATQPAFKKHFDDLIERYG-PVHIVNLV---EKKGRESKLSEAYEEAVKYLNQFL--PD 281
                         330
                  ....*....|....
gi 19920690   394 RMKHIHFDMARQSR 407
Cdd:pfam02383 282 KLRYTAFDFHHECK 295
COG5329 COG5329
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
19-599 3.04e-82

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 275.04  E-value: 3.04e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690  19 KVVLYEtRARLYLVGSNNRETRFRLLTIDRlahNRLSIEENANEFNSLEIRRFVASLSGSPKVtsaYGVLGFVRFLEGYY 98
Cdd:COG5329   2 QCFLGE-KPRSIAIVSNNYALSFRRLGVKN---SERILCATELVGVRFEPDEGFSSLSSAHKI---YGVIGLIKLKGDIY 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690  99 LLLVTKRKCCAHIGRHLVYTIKDTVMVRVNEvtSQRPPHPHED--RYKRMFQNIDLRSN--FYFSYSYDLTRTLQYNEsa 174
Cdd:COG5329  75 LIVITGASLVGVIPGHSIYKILDVDFISLNN--NKWDDELEEDeaNYDKLSELKKLLSNgtFYFSYDFDITNSLQKNL-- 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690 175 prYVGAKVDLDRDEPLPDWNtltsnvdkahervdyafrSDSRKRFVWNAYLLQPMEgIMLKDWLLEVTHGFVSQSCISIF 254
Cdd:COG5329 151 --SEGLEASVDRADLIFMWN------------------SFLLEEFINHRSKLSSLE-KQFDNFLTTVIRGFAETVDIKVG 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690 255 GRHVNVCLVARRSSRFAGTRFLKRGANFQGDVANEVETEQIVSDGQRICAFTQMRGSIPSHWSQdISKMVPKPqIQLDIC 334
Cdd:COG5329 210 GNTISLTLISRRSSERAGTRYLSRGIDDDGNVSNFVETEQIVTDSQYIFSFTQVRGSIPLFWEQ-SNLLYGPK-IKVTRS 287
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690 335 DPYAQTP-SLHFERLLFHYGaPLIMLNLVKKRErrkHESIISKELEYSIRYLNQflPPPHrmkHIHFDMARQSRLSGGNV 413
Cdd:COG5329 288 SEAAQSAfDKHFDKLREKYG-DVYVVNLLKTKG---YEAPLLELYEKHLDLSKK--PKIH---YTEFDFHKETSQDGFDD 358
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690 414 MEQLAIHAESIVqMTGMFFKAAGSEP---GLQTGIVRTNCVDCLDRTNSAQFAIGKcALGHQLERLGFVKSAKLEFdsdc 490
Cdd:COG5329 359 VKKLLYLIEQDL-LEFGYFAYDINEGksiSEQDGVFRTNCLDCLDRTNVIQSLISR-VLLEQFRSEGVISDGYSPF---- 432
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690 491 VTMLENLYEEHGDTLALQYGGSQLVHRIKTYRKTAPWGSQGSDVMQTLSRYYSNTFSDTEKQHSINLFLGIYKPSltkqg 570
Cdd:COG5329 433 LQIHRELWADNGDAISRLYTGTGALKSSFTRRGRRSFAGALNDFIKSFSRYYINNFTDGQRQDAIDLLLGKFRPQ----- 507
                       570       580
                ....*....|....*....|....*....
gi 19920690 571 ppiwELQTDYDMHNAFVPRADSKAITDWV 599
Cdd:COG5329 508 ----EAFSYRPLRITFLLLMITACTISWF 532
 
Name Accession Description Interval E-value
Syja_N pfam02383
SacI homology domain; This Pfam family represents a protein domain which shows homology to the ...
85-407 7.27e-107

SacI homology domain; This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.


Pssm-ID: 460545  Cd Length: 295  Bit Score: 330.69  E-value: 7.27e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690    85 YGVLGFVRFLEGYYLLLVTKRKCCAHIGRHLVYTIKDTVMVRVN----EVTSQRPPHPHEDRYKRMFQNIDLRSNFYFSY 160
Cdd:pfam02383   1 YGILGLIRLLSGYYLIVITKREQVGQIGGHPIYKITDVEFIPLNsslsDTQLAKKEHPDEERLLKLLKLFLSSGSFYFSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690   161 SYDLTRTLQYNESAPRYvgakvdldrdeplPDWNTLTsnvdkahervdyafrsdsrKRFVWNAYLLQPMEGIMLK--DWL 238
Cdd:pfam02383  81 DYDLTNSLQRNLTRSRS-------------PSFDSLD-------------------DRFFWNRHLLKPLIDFQLDldRWI 128
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690   239 LEVTHGFVSQSCISIFGRHVNVCLVARRSSRFAGTRFLKRGANFQGDVANEVETEQIVSD-----GQRICAFTQMRGSIP 313
Cdd:pfam02383 129 LPLIQGFVEQGKLSVFGRSVTLTLISRRSRKRAGTRYLRRGIDDDGNVANFVETEQIVSLntsnsEGKIFSFVQIRGSIP 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690   314 SHWSQDISKMVpKPQIQLDICDPYAQTPSLHFERLLFHYGaPLIMLNLVkkrERRKHESIISKELEYSIRYLNQFLppPH 393
Cdd:pfam02383 209 LFWSQDPNLKY-KPKIQITRPEATQPAFKKHFDDLIERYG-PVHIVNLV---EKKGRESKLSEAYEEAVKYLNQFL--PD 281
                         330
                  ....*....|....
gi 19920690   394 RMKHIHFDMARQSR 407
Cdd:pfam02383 282 KLRYTAFDFHHECK 295
COG5329 COG5329
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
19-599 3.04e-82

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 275.04  E-value: 3.04e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690  19 KVVLYEtRARLYLVGSNNRETRFRLLTIDRlahNRLSIEENANEFNSLEIRRFVASLSGSPKVtsaYGVLGFVRFLEGYY 98
Cdd:COG5329   2 QCFLGE-KPRSIAIVSNNYALSFRRLGVKN---SERILCATELVGVRFEPDEGFSSLSSAHKI---YGVIGLIKLKGDIY 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690  99 LLLVTKRKCCAHIGRHLVYTIKDTVMVRVNEvtSQRPPHPHED--RYKRMFQNIDLRSN--FYFSYSYDLTRTLQYNEsa 174
Cdd:COG5329  75 LIVITGASLVGVIPGHSIYKILDVDFISLNN--NKWDDELEEDeaNYDKLSELKKLLSNgtFYFSYDFDITNSLQKNL-- 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690 175 prYVGAKVDLDRDEPLPDWNtltsnvdkahervdyafrSDSRKRFVWNAYLLQPMEgIMLKDWLLEVTHGFVSQSCISIF 254
Cdd:COG5329 151 --SEGLEASVDRADLIFMWN------------------SFLLEEFINHRSKLSSLE-KQFDNFLTTVIRGFAETVDIKVG 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690 255 GRHVNVCLVARRSSRFAGTRFLKRGANFQGDVANEVETEQIVSDGQRICAFTQMRGSIPSHWSQdISKMVPKPqIQLDIC 334
Cdd:COG5329 210 GNTISLTLISRRSSERAGTRYLSRGIDDDGNVSNFVETEQIVTDSQYIFSFTQVRGSIPLFWEQ-SNLLYGPK-IKVTRS 287
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690 335 DPYAQTP-SLHFERLLFHYGaPLIMLNLVKKRErrkHESIISKELEYSIRYLNQflPPPHrmkHIHFDMARQSRLSGGNV 413
Cdd:COG5329 288 SEAAQSAfDKHFDKLREKYG-DVYVVNLLKTKG---YEAPLLELYEKHLDLSKK--PKIH---YTEFDFHKETSQDGFDD 358
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690 414 MEQLAIHAESIVqMTGMFFKAAGSEP---GLQTGIVRTNCVDCLDRTNSAQFAIGKcALGHQLERLGFVKSAKLEFdsdc 490
Cdd:COG5329 359 VKKLLYLIEQDL-LEFGYFAYDINEGksiSEQDGVFRTNCLDCLDRTNVIQSLISR-VLLEQFRSEGVISDGYSPF---- 432
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19920690 491 VTMLENLYEEHGDTLALQYGGSQLVHRIKTYRKTAPWGSQGSDVMQTLSRYYSNTFSDTEKQHSINLFLGIYKPSltkqg 570
Cdd:COG5329 433 LQIHRELWADNGDAISRLYTGTGALKSSFTRRGRRSFAGALNDFIKSFSRYYINNFTDGQRQDAIDLLLGKFRPQ----- 507
                       570       580
                ....*....|....*....|....*....
gi 19920690 571 ppiwELQTDYDMHNAFVPRADSKAITDWV 599
Cdd:COG5329 508 ----EAFSYRPLRITFLLLMITACTISWF 532
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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