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Conserved domains on  [gi|20129193|ref|NP_608754|]
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uncharacterized protein Dmel_CG44002 [Drosophila melanogaster]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 15933290)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677|GO:0003700
PubMed:  22803940|11179890|12665246|11361095|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 4-74 7.74e-11

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


:

Pssm-ID: 462262  Cd Length: 75  Bit Score: 57.47  E-value: 7.74e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20129193     4 KCRVCLASSKNMVNIFEERQDlPVSIAHMIIECTGFKVEKGDSLPHSICPPCVKDAHNAFTIIKTYERSYQ 74
Cdd:pfam07776   1 VCRLCLDESDELIPIFDPSDS-EKTLAEILEDCTGIELDPNDLLPKQICERCLSKLQEFYSFRERCLESQE 70
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
162-302 4.72e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 4.72e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129193 162 HILRHHTTDGPRPMSSTSEHAVKEELRTKARQLSrnstHTCRLCNKTFCSKASCVRHQKT--HTGE--KPFAC--EICQK 235
Cdd:COG5048 256 SASESPRSSLPTASSQSSSPNESDSSSEKGFSLP----IKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGK 331

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20129193 236 PFADLASVKRHLRTHTGERPFKCLTCQSAFSDGSAL----RQHIRIHTGERPYKCDMCDKFFRERSDARKH 302
Cdd:COG5048 332 LFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnnepPQSLQQYKDLKNDKKSETLSNSCIRNFKRDS 402
SUF4-like super family cl41227
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 282-342 7.75e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


The actual alignment was detected with superfamily member cd20908:

Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 34.84  E-value: 7.75e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 20129193 282 RPYkCDMCDKFFrersDARKHMMSHTAEKRFKCSQCERRFRQPKGLRRHVKLCHT---DKVENA 342
Cdd:cd20908   1 KPW-CYYCDREF----DDEKILIQHQKAKHFKCHICHKKLYTAGGLAVHCLQVHKetlTKVPNA 59
 
Name Accession Description Interval E-value
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 4-74 7.74e-11

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 462262  Cd Length: 75  Bit Score: 57.47  E-value: 7.74e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20129193     4 KCRVCLASSKNMVNIFEERQDlPVSIAHMIIECTGFKVEKGDSLPHSICPPCVKDAHNAFTIIKTYERSYQ 74
Cdd:pfam07776   1 VCRLCLDESDELIPIFDPSDS-EKTLAEILEDCTGIELDPNDLLPKQICERCLSKLQEFYSFRERCLESQE 70
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 5-76 2.11e-10

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 214871  Cd Length: 73  Bit Score: 56.37  E-value: 2.11e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20129193      5 CRVCLASSKNMVNIFEERQDlpVSIAHMIIECTGFKVEKGDSLPHSICPPCVKDAHNAFTIIKTYERSYQVF 76
Cdd:smart00868   2 CRLCLSESENLVSIFDESSE--ASLAEKIEECTGIEIEPDDGLPKVICGDCLEKLESFHKFRERCRESDELL 71
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
162-302 4.72e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 4.72e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129193 162 HILRHHTTDGPRPMSSTSEHAVKEELRTKARQLSrnstHTCRLCNKTFCSKASCVRHQKT--HTGE--KPFAC--EICQK 235
Cdd:COG5048 256 SASESPRSSLPTASSQSSSPNESDSSSEKGFSLP----IKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGK 331

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20129193 236 PFADLASVKRHLRTHTGERPFKCLTCQSAFSDGSAL----RQHIRIHTGERPYKCDMCDKFFRERSDARKH 302
Cdd:COG5048 332 LFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnnepPQSLQQYKDLKNDKKSETLSNSCIRNFKRDS 402
zf-H2C2_2 pfam13465
Zinc-finger double domain;
270-293 1.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.27e-04
                          10        20
                  ....*....|....*....|....
gi 20129193   270 ALRQHIRIHTGERPYKCDMCDKFF 293
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 282-342 7.75e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 34.84  E-value: 7.75e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 20129193 282 RPYkCDMCDKFFrersDARKHMMSHTAEKRFKCSQCERRFRQPKGLRRHVKLCHT---DKVENA 342
Cdd:cd20908   1 KPW-CYYCDREF----DDEKILIQHQKAKHFKCHICHKKLYTAGGLAVHCLQVHKetlTKVPNA 59
 
Name Accession Description Interval E-value
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 4-74 7.74e-11

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 462262  Cd Length: 75  Bit Score: 57.47  E-value: 7.74e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20129193     4 KCRVCLASSKNMVNIFEERQDlPVSIAHMIIECTGFKVEKGDSLPHSICPPCVKDAHNAFTIIKTYERSYQ 74
Cdd:pfam07776   1 VCRLCLDESDELIPIFDPSDS-EKTLAEILEDCTGIELDPNDLLPKQICERCLSKLQEFYSFRERCLESQE 70
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 5-76 2.11e-10

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 214871  Cd Length: 73  Bit Score: 56.37  E-value: 2.11e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20129193      5 CRVCLASSKNMVNIFEERQDlpVSIAHMIIECTGFKVEKGDSLPHSICPPCVKDAHNAFTIIKTYERSYQVF 76
Cdd:smart00868   2 CRLCLSESENLVSIFDESSE--ASLAEKIEECTGIEIEPDDGLPKVICGDCLEKLESFHKFRERCRESDELL 71
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
162-302 4.72e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 4.72e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129193 162 HILRHHTTDGPRPMSSTSEHAVKEELRTKARQLSrnstHTCRLCNKTFCSKASCVRHQKT--HTGE--KPFAC--EICQK 235
Cdd:COG5048 256 SASESPRSSLPTASSQSSSPNESDSSSEKGFSLP----IKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGK 331

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20129193 236 PFADLASVKRHLRTHTGERPFKCLTCQSAFSDGSAL----RQHIRIHTGERPYKCDMCDKFFRERSDARKH 302
Cdd:COG5048 332 LFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnnepPQSLQQYKDLKNDKKSETLSNSCIRNFKRDS 402
zf-H2C2_2 pfam13465
Zinc-finger double domain;
270-293 1.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.27e-04
                          10        20
                  ....*....|....*....|....
gi 20129193   270 ALRQHIRIHTGERPYKCDMCDKFF 293
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
226-318 4.89e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 4.89e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129193 226 KPFACEICQKPFADLASVKRHLRTHTGERPFKCL--TCQSAFSDGSALRQHIRIHTGERPYkcDMCDKFFRERSDARKHM 303
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                        90
                ....*....|....*
gi 20129193 304 MSHTAEKRFKCSQCE 318
Cdd:COG5048 110 LSSSSSNSNDNNLLS 124
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
120-302 2.84e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 2.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129193 120 PTNEVSTQEESKTAQSDNVSEDKGHICTQCHMSFRRPGLLELHI-LRHHTTDGPRPMSSTSEHAVKEELRTKA-RQLSRN 197
Cdd:COG5048 266 PTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLrSVNHSGESLKPFSCPYSLCGKLFSRNDAlKRHILL 345

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129193 198 STHTCRLCNKTF-CSK----------ASCVRHQKTHTGEKPFACE--ICQKPFADLASVKRHLRTHTGERP--FKCLTCQ 262
Cdd:COG5048 346 HTSISPAKEKLLnSSSkfspllnnepPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCS 425

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 20129193 263 SAFSDGSALRQHIRIHTGERPYKCDMCDKFFRERSDARKH 302
Cdd:COG5048 426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHG 465
zf-H2C2_2 pfam13465
Zinc-finger double domain;
242-266 3.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.48e-03
                          10        20
                  ....*....|....*....|....*
gi 20129193   242 SVKRHLRTHTGERPFKCLTCQSAFS 266
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 282-342 7.75e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 34.84  E-value: 7.75e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 20129193 282 RPYkCDMCDKFFrersDARKHMMSHTAEKRFKCSQCERRFRQPKGLRRHVKLCHT---DKVENA 342
Cdd:cd20908   1 KPW-CYYCDREF----DDEKILIQHQKAKHFKCHICHKKLYTAGGLAVHCLQVHKetlTKVPNA 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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