NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24580641|ref|NP_608524|]
View 

Bardet-Biedl syndrome 8 [Drosophila melanogaster]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TTC8_N cd21341
N-terminal domain of tetratricopeptide repeat domain 8; Tetratricopeptide repeat domain 8 ...
 96-215 1.15e-27

N-terminal domain of tetratricopeptide repeat domain 8; Tetratricopeptide repeat domain 8 (TTC80), also known a BBS8, has been directly linked to Bardet-Biedl syndrome, an autosomal recessive ciliopathy characterized by retinal degeneration, renal failure, obesity, diabetes, male infertility, polydactyly and cognitive impairment. Mutations in BBS8 cause early vision loss. In addition to C-terminal tetratricopeptide repeats, TTC8 also contains an N-terminal domain of unknown function.


:

Pssm-ID: 411061 [Multi-domain]  Cd Length: 139  Bit Score: 108.16  E-value: 1.15e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641  96 IMMPTWLMEGVWQLKMRALTQRVYVDDLDEDDGGNeATEEVEFERIATAARPGSSIKTAFQPRPLTSQRAQQARSRGAGV 175
Cdd:cd21341   1 LLEKNPYDQAAWFLKMRALTEQVYIDDTEVDEEGI-AELLMDENVIATVPRPGTSLRRPTTSAGGPSQAMRPTTSSGRPI 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 24580641 176 AHSSDGRLNSSRPGSAAVARPGT---SLSRPGSSLGS---RCGTAS 215
Cdd:cd21341  80 TGFVRPGTQSGRPGTSRQALRTPrraGTARPVTSASGrfvRLGTAS 125
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 299-536 4.61e-21

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 93.26  E-value: 4.61e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 299 QMGRCLLALHYPRRAEPFLQQSLTSFP-HPDTYLLLSRVYQRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQ 377
Cdd:COG2956  13 FKGLNYLLNGQPDKAIDLLEEALELDPeTVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 378 EDALQLYRLAAKLHPINVESLASIAVGYFYDNNPEMALMYYRRILSLGAQSPELYCNIALCCLYGGQIDLVLPCFQRALA 457
Cdd:COG2956  93 DRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALK 172

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24580641 458 TAtqpGQKSDIWYNLSFVAVTSGDFNLAKRCLQLCLTSDAQNGAALNNLAVLAAQSGDILGAKSYLNAAKDVMPDAAEV 536
Cdd:COG2956 173 LD---PDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLL 248
 
Name Accession Description Interval E-value
TTC8_N cd21341
N-terminal domain of tetratricopeptide repeat domain 8; Tetratricopeptide repeat domain 8 ...
 96-215 1.15e-27

N-terminal domain of tetratricopeptide repeat domain 8; Tetratricopeptide repeat domain 8 (TTC80), also known a BBS8, has been directly linked to Bardet-Biedl syndrome, an autosomal recessive ciliopathy characterized by retinal degeneration, renal failure, obesity, diabetes, male infertility, polydactyly and cognitive impairment. Mutations in BBS8 cause early vision loss. In addition to C-terminal tetratricopeptide repeats, TTC8 also contains an N-terminal domain of unknown function.


Pssm-ID: 411061 [Multi-domain]  Cd Length: 139  Bit Score: 108.16  E-value: 1.15e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641  96 IMMPTWLMEGVWQLKMRALTQRVYVDDLDEDDGGNeATEEVEFERIATAARPGSSIKTAFQPRPLTSQRAQQARSRGAGV 175
Cdd:cd21341   1 LLEKNPYDQAAWFLKMRALTEQVYIDDTEVDEEGI-AELLMDENVIATVPRPGTSLRRPTTSAGGPSQAMRPTTSSGRPI 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 24580641 176 AHSSDGRLNSSRPGSAAVARPGT---SLSRPGSSLGS---RCGTAS 215
Cdd:cd21341  80 TGFVRPGTQSGRPGTSRQALRTPrraGTARPVTSASGrfvRLGTAS 125
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 299-536 4.61e-21

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 93.26  E-value: 4.61e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 299 QMGRCLLALHYPRRAEPFLQQSLTSFP-HPDTYLLLSRVYQRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQ 377
Cdd:COG2956  13 FKGLNYLLNGQPDKAIDLLEEALELDPeTVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 378 EDALQLYRLAAKLHPINVESLASIAVGYFYDNNPEMALMYYRRILSLGAQSPELYCNIALCCLYGGQIDLVLPCFQRALA 457
Cdd:COG2956  93 DRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALK 172

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24580641 458 TAtqpGQKSDIWYNLSFVAVTSGDFNLAKRCLQLCLTSDAQNGAALNNLAVLAAQSGDILGAKSYLNAAKDVMPDAAEV 536
Cdd:COG2956 173 LD---PDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLL 248
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 221-515 5.87e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 52.39  E-value: 5.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641   221 SAAAFNVGDATSKLYQASRLNPTIYAERETLVKAlfqflYYHEADVQKAHSLCQAVLEVERQKPSgstgctlswWWQQqM 300
Cdd:TIGR02917 543 YLRTGNEEEAVAWLEKAAELNPQEIEPALALAQY-----YLGKGQLKKALAILNEAADAAPDSPE---------AWLM-L 607

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641   301 GRCLLALHYPRRAEPFLQQSLTSFP-HPDTYLLLSRVYQRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQED 379
Cdd:TIGR02917 608 GRAQLAAGDLNKAVSSFKKLLALQPdSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTES 687

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641   380 ALQLYRLAAKLHPINVESLASIAVGYFYDNNPEMALMYYRRILSLGAQSpelycnialcclyggQIDLVLPCFQRALATA 459
Cdd:TIGR02917 688 AKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSS---------------QNAIKLHRALLASGNT 752

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24580641   460 TQPGQKSDIW-----------YNLSFVAVTSGDFNLAKRCLQLCLTSDAQNGAALNNLAVLAAQSGD 515
Cdd:TIGR02917 753 AEAVKTLEAWlkthpndavlrTALAELYLAQKDYDKAIKHYQTVVKKAPDNAVVLNNLAWLYLELKD 819
Coatomer_WDAD pfam04053
Coatomer WD associated region; This region is composed of WD40 repeats.
 374-519 1.16e-04

Coatomer WD associated region; This region is composed of WD40 repeats.


Pssm-ID: 427679  Cd Length: 439  Bit Score: 44.53  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641   374 MEQQEDALQLYRLAAKLHPINvESLASIAvGYFYD-NNPEMALMYyrrilslgAQSPELYCNIALCClygGQIDLvlpcf 452
Cdd:pfam04053 271 LRKDYEEVLRIIRASNLLPPK-DEGQKII-RYLEKkGYPEIALQF--------VQDPDTRFDLALEL---GNLDV----- 332

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24580641   453 qrALATATQPGQKsDIWYNLSFVAVTSGDFNLAKRCLQLC--------LTSDAQNGAALNNLAVLAAQSGDILGA 519
Cdd:pfam04053 333 --ALEIAKELDDP-AKWKRLGDAALSQGNIKLAEEAYQKAkdfdklllLYLSTGNMEKLKKLAKIAEKRGDYNSA 404
 
Name Accession Description Interval E-value
TTC8_N cd21341
N-terminal domain of tetratricopeptide repeat domain 8; Tetratricopeptide repeat domain 8 ...
 96-215 1.15e-27

N-terminal domain of tetratricopeptide repeat domain 8; Tetratricopeptide repeat domain 8 (TTC80), also known a BBS8, has been directly linked to Bardet-Biedl syndrome, an autosomal recessive ciliopathy characterized by retinal degeneration, renal failure, obesity, diabetes, male infertility, polydactyly and cognitive impairment. Mutations in BBS8 cause early vision loss. In addition to C-terminal tetratricopeptide repeats, TTC8 also contains an N-terminal domain of unknown function.


Pssm-ID: 411061 [Multi-domain]  Cd Length: 139  Bit Score: 108.16  E-value: 1.15e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641  96 IMMPTWLMEGVWQLKMRALTQRVYVDDLDEDDGGNeATEEVEFERIATAARPGSSIKTAFQPRPLTSQRAQQARSRGAGV 175
Cdd:cd21341   1 LLEKNPYDQAAWFLKMRALTEQVYIDDTEVDEEGI-AELLMDENVIATVPRPGTSLRRPTTSAGGPSQAMRPTTSSGRPI 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 24580641 176 AHSSDGRLNSSRPGSAAVARPGT---SLSRPGSSLGS---RCGTAS 215
Cdd:cd21341  80 TGFVRPGTQSGRPGTSRQALRTPrraGTARPVTSASGrfvRLGTAS 125
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 299-536 4.61e-21

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 93.26  E-value: 4.61e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 299 QMGRCLLALHYPRRAEPFLQQSLTSFP-HPDTYLLLSRVYQRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQ 377
Cdd:COG2956  13 FKGLNYLLNGQPDKAIDLLEEALELDPeTVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 378 EDALQLYRLAAKLHPINVESLASIAVGYFYDNNPEMALMYYRRILSLGAQSPELYCNIALCCLYGGQIDLVLPCFQRALA 457
Cdd:COG2956  93 DRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALK 172

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24580641 458 TAtqpGQKSDIWYNLSFVAVTSGDFNLAKRCLQLCLTSDAQNGAALNNLAVLAAQSGDILGAKSYLNAAKDVMPDAAEV 536
Cdd:COG2956 173 LD---PDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLL 248
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
358-534 8.68e-16

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 76.97  E-value: 8.68e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 358 PFDVTYRLEQARIHQAMEQQEDALQLYRLAAKLHPINVESLASIAVGYFYDNNPEMALMYYRRILSLGAQSPELYCNIAL 437
Cdd:COG0457   5 PDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 438 CCLYGGQIDLVLPCFQRALATAtqpGQKSDIWYNLSFVAVTSGDFNLAKRCLQLCLTSDAQNGAALNNLAVLAAQSGDIL 517
Cdd:COG0457  85 ALQALGRYEEALEDYDKALELD---PDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYE 161

                       170
                ....*....|....*..
gi 24580641 518 GAKSYLNAAKDVMPDAA 534
Cdd:COG0457 162 EALELLEKLEAAALAAL 178
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 330-549 3.45e-15

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 75.92  E-value: 3.45e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 330 YLLLSRVYQRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQEDALQLYRLAAKLHPINVESLASIAVGYFYDN 409
Cdd:COG2956  11 WYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAG 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 410 NPEMALMYYRRILSLGAQSPELYCNIALCCLYGGQIDLVLPCFQRALATAtqpGQKSDIWYNLSFVAVTSGDFNLAKRCL 489
Cdd:COG2956  91 LLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLG---PENAHAYCELAELYLEQGDYDEAIEAL 167

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 490 QLCLTSDAQNGAALNNLAVLAAQSGDILGAKSYLNAAKDVMPDAAEVTTNLqfMDVHYKL 549
Cdd:COG2956 168 EKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRL--AELYEKL 225
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 363-542 6.09e-15

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 77.73  E-value: 6.09e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 363 YRLEQARIHQAMEQQEDALQLYRLAAKLHPINVESLASIAVGYFYDNNPEMALMYYRRILSLGAQSPELYCNIALCCLYG 442
Cdd:COG3914  46 LLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLAL 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 443 GQIDLVLPCFQRALATatQPGQkSDIWYNLSFVAVTSGDFNLAKRCLQLCLTSDAQNGAALNNLAVLAAQSGDILGAKSY 522
Cdd:COG3914 126 GRLEEALAALRRALAL--NPDF-AEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAA 202

                       170       180
                ....*....|....*....|
gi 24580641 523 LNAAKDVMPDAAEVTTNLQF 542
Cdd:COG3914 203 YRRALELDPDNADAHSNLLF 222
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
326-528 2.42e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 72.73  E-value: 2.42e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 326 HPDTYLLLSRVYQRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQEDALQLYRLAAKLHPINVESLASIAVGY 405
Cdd:COG0457   7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 406 FYDNNPEMALMYYRRILSLGAQSPELYCNIALCCLYGGQIDLVLPCFQRALATATQPgqkSDIWYNLSFVAVTSGDFNLA 485
Cdd:COG0457  87 QALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDD---ADALYNLGIALEKLGRYEEA 163

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 24580641 486 KRCLQLCLTSDAQNGAALNNLAVLAAQSGDILGAKSYLNAAKD 528
Cdd:COG0457 164 LELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQA 206
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
300-527 4.71e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 69.27  E-value: 4.71e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 300 MGRCLLALHYPRRAEPFLQQSLTSFP-HPDTYLLLSRVYQRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQE 378
Cdd:COG0457  14 LGLAYRRLGRYEEAIEDYEKALELDPdDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYE 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 379 DALQLYRLAAKLHPINVESLASIAVGYFYDNNPEMALMYYRRILSLGAQSPELYCNIALCCLYGGQIDLVLPCFQRALAT 458
Cdd:COG0457  94 EALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAA 173

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24580641 459 ATQPGQKSDIWYNLSFVAVTSGDFNLAKRCLQLCLTSDAQNGAALNNLAVLAAQSGDILGAKSYLNAAK 527
Cdd:COG0457 174 ALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQ 242
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
389-540 6.72e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.49  E-value: 6.72e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 389 KLHPINVESLASIAVGYFYDNNPEMALMYYRRILSLGAQSPELYCNIALCCLYGGQIDLVLPCFQRALatATQPGQkSDI 468
Cdd:COG0457   2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQAL--ELDPDD-AEA 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24580641 469 WYNLSFVAVTSGDFNLAKRCLQLCLTSDAQNGAALNNLAVLAAQSGDILGAKSYLNAAKDVMPDAAEVTTNL 540
Cdd:COG0457  79 LNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNL 150
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 304-466 1.27e-12

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 70.41  E-value: 1.27e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 304 LLALHYPRRAEPFLQQSLTSFP-HPDTYLLLSRVYQRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQEDALQ 382
Cdd:COG3914  88 LQALGRYEEALALYRRALALNPdNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIA 167

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 383 LYRLAAKLHPINVESLASIAVGYFYDNNPEMALMYYRRILSLGAQSPELYCNIALCCLYGGQIDLVLPCFQRALATATQP 462
Cdd:COG3914 168 ALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDRFEELLAALARGP 247


                ....
gi 24580641 463 GQKS 466
Cdd:COG3914 248 SELS 251
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 254-515 1.80e-12

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 70.02  E-value: 1.80e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 254 ALFQFLYYHEADVQKAHSLCQAVLEVERQKPSGSTGCTLSWWWQQQMGRCLLALHYPRRAEPFLQQSLTSFPHPDTYLLL 333
Cdd:COG3914   5 ALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 334 SRVYQRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQEDALQLYRLAAKLHPINVESLASIAVGYFYDNNPEM 413
Cdd:COG3914  85 ALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEE 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 414 ALMYYRRILSLGAQSPELYCNIALCCLYGGQIDLVLPCFQRALatATQPGQkSDIWYNLSFVAVTSGDFNLAKRCLQLcL 493
Cdd:COG3914 165 AIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRAL--ELDPDN-ADAHSNLLFALRQACDWEVYDRFEEL-L 240

                       250       260
                ....*....|....*....|..
gi 24580641 494 TSDAQNGAALNNLAVLAAQSGD 515
Cdd:COG3914 241 AALARGPSELSPFALLYLPDDD 262
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 317-432 5.81e-11

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 60.02  E-value: 5.81e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 317 LQQSLTSFP-HPDTYLLLSRVYQRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQEDALQLYRLAAKLHPINV 395
Cdd:COG4235   6 LRQALAANPnDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNP 85

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 24580641 396 ESLASIAVGYFYDNNPEMALMYYRRILSLGAQSPELY 432
Cdd:COG4235  86 EALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPAR 122
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 328-457 9.96e-11

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 59.82  E-value: 9.96e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 328 DTYLLLSRVYQRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQEDALQLYRLAAKLHPINVESLASIAVGYFY 407
Cdd:COG4783   5 EALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 24580641 408 DNNPEMALMYYRRILSLGAQSPELYCNIALCCLYGGQIDLVLPCFQRALA 457
Cdd:COG4783  85 AGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALE 134
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 259-432 1.75e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 62.05  E-value: 1.75e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 259 LYYHEADVQKAHSLCQAVLEVERQKPSGstgctlswwwQQQMGRCLLALHYPRRAEPFLQQSLTSFP-HPDTYLLLSRVY 337
Cdd:COG2956  85 DYLKAGLLDRAEELLEKLLELDPDDAEA----------LRLLAEIYEQEGDWEKAIEVLERLLKLGPeNAHAYCELAELY 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 338 QRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQEDALQLYRLAAKLHPINVESLASIAVGYFYDNNPEMALMY 417
Cdd:COG2956 155 LEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALEL 234

                       170
                ....*....|....*
gi 24580641 418 YRRILSLGAQSPELY 432
Cdd:COG2956 235 LRKALELDPSDDLLL 249
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 360-499 1.83e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 59.05  E-value: 1.83e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 360 DVTYRLEQARIHQAMEQQEDALQLYRLAAKLHPINVESLASIAVGYFYDNNPEMALMYYRRILSLGAQSPELYCNIALCC 439
Cdd:COG4783   3 CAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLAL 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 440 LYGGQIDLVLPCFQRALatATQPGQkSDIWYNLSFVAVTSGDFNLAKRCLQLCLTSDAQN 499
Cdd:COG4783  83 LKAGDYDEALALLEKAL--KLDPEH-PEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 297-424 3.27e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 58.28  E-value: 3.27e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 297 QQQMGRCLLALHYPRRAEPFLQQSLTSFP-HPDTYLLLSRVYQRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAME 375
Cdd:COG4783   7 LYALAQALLLAGDYDEAEALLEKALELDPdNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAG 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 24580641 376 QQEDALQLYRLAAKLHPINVESLASIAVGYFYDNNPEMALMYYRRILSL 424
Cdd:COG4783  87 DYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALEL 135
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 395-532 6.61e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 57.51  E-value: 6.61e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 395 VESLASIAVGYFYDNNPEMALMYYRRILSLGAQSPELYCNIALCCLYGGQIDLVLPCFQRALATatQPGQkSDIWYNLSF 474
Cdd:COG4783   4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALEL--DPDE-PEARLNLGL 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24580641 475 VAVTSGDFNLAKRCLQLCLTSDAQNGAALNNLAVLAAQSGDILGAKSYLNAAKDVMPD 532
Cdd:COG4783  81 ALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPD 138
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 345-459 1.53e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 56.17  E-value: 1.53e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 345 RALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQEDALQLYRLAAKLHPINVESLASIAVGYFYDNNPEMALMYYRRILSL 424
Cdd:COG4235   1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 24580641 425 GAQSPELYCNIALCCLYGGQIDLVLPCFQRALATA 459
Cdd:COG4235  81 DPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALL 115
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 379-535 3.21e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 52.32  E-value: 3.21e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 379 DALQLYRLAAKLHPINVESLASIAVGYFYDNNPEMALMYYRRILSLGAQSPELYCNIALCCLYGGQIDLVLPCFQRALAT 458
Cdd:COG4235   1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24580641 459 atqpgqksdiwynlsfvavtsgdfnlakrclqlcltsDAQNGAALNNLAVLAAQSGDILGAKSYLNAAKDVMPDAAE 535
Cdd:COG4235  81 -------------------------------------DPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAP 120
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 259-392 1.45e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 50.58  E-value: 1.45e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 259 LYYHEADVQKAHSLCQAVLEVERQKPsgstgctlswWWQQQMGRCLLALHYPRRAEPFLQQSLTSFP-HPDTYLLLSRVY 337
Cdd:COG4783  13 ALLLAGDYDEAEALLEKALELDPDNP----------EAFALLGEILLQLGDLDEAIVLLHEALELDPdEPEARLNLGLAL 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 24580641 338 QRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQEDALQLYRLAAKLHP 392
Cdd:COG4783  83 LKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDP 137
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 299-422 1.90e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.81  E-value: 1.90e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 299 QMGRCLLALHYPRRAEPFLQQSLTSFP-HPDTYLLLSRVYQRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQ 377
Cdd:COG2956 149 ELAELYLEQGDYDEAIEALEKALKLDPdCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDP 228

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 24580641 378 EDALQLYRLAAKLHPINVESLAsIAVGYFYDNNPEMALMYYRRIL 422
Cdd:COG2956 229 EEALELLRKALELDPSDDLLLA-LADLLERKEGLEAALALLERQL 272
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
422-540 5.62e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.78  E-value: 5.62e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 422 LSLGAQSPELYCNIALCCLYGGQIDLVLPCFQRALatATQPGQkSDIWYNLSFVAVTSGDFNLAKRCLQLCLTSDAQNGA 501
Cdd:COG0457   1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKAL--ELDPDD-AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAE 77

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 24580641 502 ALNNLAVLAAQSGDILGAKSYLNAAKDVMPDAAEVTTNL 540
Cdd:COG0457  78 ALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNL 116
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 221-515 5.87e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 52.39  E-value: 5.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641   221 SAAAFNVGDATSKLYQASRLNPTIYAERETLVKAlfqflYYHEADVQKAHSLCQAVLEVERQKPSgstgctlswWWQQqM 300
Cdd:TIGR02917 543 YLRTGNEEEAVAWLEKAAELNPQEIEPALALAQY-----YLGKGQLKKALAILNEAADAAPDSPE---------AWLM-L 607

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641   301 GRCLLALHYPRRAEPFLQQSLTSFP-HPDTYLLLSRVYQRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQED 379
Cdd:TIGR02917 608 GRAQLAAGDLNKAVSSFKKLLALQPdSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTES 687

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641   380 ALQLYRLAAKLHPINVESLASIAVGYFYDNNPEMALMYYRRILSLGAQSpelycnialcclyggQIDLVLPCFQRALATA 459
Cdd:TIGR02917 688 AKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSS---------------QNAIKLHRALLASGNT 752

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24580641   460 TQPGQKSDIW-----------YNLSFVAVTSGDFNLAKRCLQLCLTSDAQNGAALNNLAVLAAQSGD 515
Cdd:TIGR02917 753 AEAVKTLEAWlkthpndavlrTALAELYLAQKDYDKAIKHYQTVVKKAPDNAVVLNNLAWLYLELKD 819
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 304-532 1.03e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 51.62  E-value: 1.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641   304 LLALHYPRRAE-----PFLQQSLTSFP-HPDTYLLLSRVYQRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQ 377
Cdd:TIGR02917 436 LLILSYLRSGQfdkalAAAKKLEKKQPdNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNP 515

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641   378 EDALQLYRLAAKLHPINVESLASIAVGYFYDNNPEMALMYYRRILSLGAQSPELYCNIALCCLYGGQIDLVLPCFQRALA 457
Cdd:TIGR02917 516 DDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAAD 595

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24580641   458 TATQPGQksdIWYNLSFVAVTSGDFNLAKRCLQLCLTSDAQNGAALNNLAVLAAQSGDILGAKSYLNAAKDVMPD 532
Cdd:TIGR02917 596 AAPDSPE---AWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPD 667
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 362-457 1.72e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 48.03  E-value: 1.72e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 362 TYRLEQARIHQAMEQQEDALQLYRLAAKLHPINVESLASIAVGYFYDNNPEMALMYYRRILSLGAQSPELYCNIALCCLY 441
Cdd:COG5010  55 AIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLS 134

                        90
                ....*....|....*.
gi 24580641 442 GGQIDLVLPCFQRALA 457
Cdd:COG5010 135 LGQDDEAKAALQRALG 150
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
370-457 3.27e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 45.55  E-value: 3.27e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 370 IHQAMEQQEDALQLYRLAAKLHPINVESLASIAVGYFYDNNPEMALMyYRRILSLGAQSPELYCNIALCCLYGGQIDLVL 449
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEAL 79


                ....*...
gi 24580641 450 PCFQRALA 457
Cdd:COG3063  80 AYLERALE 87
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
336-426 6.23e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 42.08  E-value: 6.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 336 VYQRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQEDALQlYRLAAKLHPINVESLASIAVGYFYDNNPEMAL 415
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEAL 79

                        90
                ....*....|.
gi 24580641 416 MYYRRILSLGA 426
Cdd:COG3063  80 AYLERALELDP 90
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 480-540 1.01e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 43.03  E-value: 1.01e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24580641 480 GDFNLAKRCLQLCLTSDAQNGAALNNLAVLAAQSGDILGAKSYLNAAKDVMPDAAEVTTNL 540
Cdd:COG5010  68 GDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNL 128
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 414-531 1.02e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 43.03  E-value: 1.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 414 ALMYYRRILSLGAQSPELYCNIALCCLYGGQIDLVLPCFQRALATAtqpGQKSDIWYNLSFVAVTSGDFNLAKRCLQLCL 493
Cdd:COG5010  39 EDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLD---PNNPELYYNLALLYSRSGDKDEAKEYYEKAL 115

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 24580641 494 TSDAQNGAALNNLAVLAAQSGDILGAKSYLNAAKDVMP 531
Cdd:COG5010 116 ALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
Coatomer_WDAD pfam04053
Coatomer WD associated region; This region is composed of WD40 repeats.
 374-519 1.16e-04

Coatomer WD associated region; This region is composed of WD40 repeats.


Pssm-ID: 427679  Cd Length: 439  Bit Score: 44.53  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641   374 MEQQEDALQLYRLAAKLHPINvESLASIAvGYFYD-NNPEMALMYyrrilslgAQSPELYCNIALCClygGQIDLvlpcf 452
Cdd:pfam04053 271 LRKDYEEVLRIIRASNLLPPK-DEGQKII-RYLEKkGYPEIALQF--------VQDPDTRFDLALEL---GNLDV----- 332

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24580641   453 qrALATATQPGQKsDIWYNLSFVAVTSGDFNLAKRCLQLC--------LTSDAQNGAALNNLAVLAAQSGDILGA 519
Cdd:pfam04053 333 --ALEIAKELDDP-AKWKRLGDAALSQGNIKLAEEAYQKAkdfdklllLYLSTGNMEKLKKLAKIAEKRGDYNSA 404
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 259-490 1.52e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 44.69  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641   259 LYYHEADVQKAHSLCQavlEVERQKPSGSTGctlswwwQQQMGRCLLALHYPRRAEPFLQQSLTSFPHPDTYLLLSRVYQ 338
Cdd:TIGR02917 678 LLLAAKRTESAKKIAK---SLQKQHPKAALG-------FELEGDLYLRQKDYPAAIQAYRKALKRAPSSQNAIKLHRALL 747

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641   339 RIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQEDALQLYRLAAKLHPINVESLASIAVGYFYDNNPEmALMYY 418
Cdd:TIGR02917 748 ASGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAPDNAVVLNNLAWLYLELKDPR-ALEYA 826

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24580641   419 RRILSLGAQSPELYCNIALCCLYGGQIDLVLPCFQRALATATQPGqksDIWYNLSFVAVTSGDFNLAKRCLQ 490
Cdd:TIGR02917 827 ERALKLAPNIPAILDTLGWLLVEKGEADRALPLLRKAVNIAPEAA---AIRYHLALALLATGRKAEARKELD 895
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 297-542 2.61e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.92  E-value: 2.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641   297 QQQMGRCLLALHY-----PRRAEPFLQQSLTSFP-HPDTYLLLSRVYQRIKQPERALLVIGEVVDSRPFDVTYRLEQARI 370
Cdd:TIGR02917 565 QEIEPALALAQYYlgkgqLKKALAILNEAADAAPdSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADA 644

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641   371 HQAMEQQEDALQLYRLAAKLHPINVESLASIAVGYFYDNNPEMALMYYRRILS---LGAQSPELYCNIALcclYGGQIDL 447
Cdd:TIGR02917 645 YAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKqhpKAALGFELEGDLYL---RQKDYPA 721

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641   448 VLPCFQRALATAtqPGqkSDIWYNLSFVAVTSGDFNLAKRCLQLCLTSDAQNGAALNNLAVLAAQSGDILGAKSYLNAAK 527
Cdd:TIGR02917 722 AIQAYRKALKRA--PS--SQNAIKLHRALLASGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVV 797

                         250
                  ....*....|....*
gi 24580641   528 DVMPDAAEVTTNLQF 542
Cdd:TIGR02917 798 KKAPDNAVVLNNLAW 812
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 304-424 6.09e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 40.71  E-value: 6.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 304 LLALHYPRRAEPFLQQSLTSFPHPDTYLLLSRVYQRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQEDALQL 383
Cdd:COG5010  31 LAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEY 110

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 24580641 384 YRLAAKLHPINVESLASIAVGYFYDNNPEMALMYYRRILSL 424
Cdd:COG5010 111 YEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGT 151
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 426-540 7.69e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.79  E-value: 7.69e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 426 AQSPELYCNIALCCLYGGQIDLVLPCFQRALATAtqpGQKSDIWYNLSFVAVTSGDFNLAKRCLQLCLTSDAQNGAALNN 505
Cdd:COG4783   1 AACAEALYALAQALLLAGDYDEAEALLEKALELD---PDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLN 77

                        90       100       110
                ....*....|....*....|....*....|....*
gi 24580641 506 LAVLAAQSGDILGAKSYLNAAKDVMPDAAEVTTNL 540
Cdd:COG4783  78 LGLALLKAGDYDEALALLEKALKLDPEHPEAYLRL 112
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
443-535 8.19e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 38.61  E-value: 8.19e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 443 GQIDLVLPCFQRALATAtqPGQkSDIWYNLSFVAVTSGDFNLAKRcLQLCLTSDAQNGAALNNLAVLAAQSGDILGAKSY 522
Cdd:COG3063   6 GDLEEAEEYYEKALELD--PDN-ADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALAY 81

                        90
                ....*....|...
gi 24580641 523 LNAAKDVMPDAAE 535
Cdd:COG3063  82 LERALELDPSALR 94
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 259-391 1.28e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.87  E-value: 1.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641 259 LYYHEADVQKAHSLCQAVLEVERQKPSGSTgctlswwwqqQMGRCLLALHYPRRAEPFLQQSLTSFP-HPDTYLLLSRVY 337
Cdd:COG2956 153 LYLEQGDYDEAIEALEKALKLDPDCARALL----------LLAELYLEQGDYEEAIAALERALEQDPdYLPALPRLAELY 222

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 24580641 338 QRIKQPERALLVIGEVVDSRPfDVTYRLEQARIHQAMEQQEDALQLYRLAAKLH 391
Cdd:COG2956 223 EKLGDPEEALELLRKALELDP-SDDLLLALADLLERKEGLEAALALLERQLRRH 275
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 305-540 5.65e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.68  E-value: 5.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641   305 LALHYPRRAEPFLQQSLTSFP-HPDTYLLLSRVYQRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQEDALQL 383
Cdd:TIGR02917 136 LGLGQLELAQKSYEQALAIDPrSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAA 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641   384 YRLAAKLHPINVESLASIAVGYFYDNNPEMALMYYRRILSLGAQSPE-LYcnialcclYGGQIDLVLPCFQRALATATQP 462
Cdd:TIGR02917 216 YRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKAPNSPLaHY--------LKALVDFQKKNYEDARETLQDA 287

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641   463 GQKSDIWYNLSFVAVTS--------------------------------------GDFNLAKRCLQLCLTSDAQNGAALN 504
Cdd:TIGR02917 288 LKSAPEYLPALLLAGASeyqlgnleqayqylnqilkyapnshqarrllasiqlrlGRVDEAIATLSPALGLDPDDPAALS 367

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 24580641   505 NLAVLAAQSGDILGAKSYLNAAKDVMPDAAEVTTNL 540
Cdd:TIGR02917 368 LLGEAYLALGDFEKAAEYLAKATELDPENAAARTQL 403
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 317-544 8.60e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.91  E-value: 8.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641   317 LQQSLTSFP-HPDTYLLLSRVYQRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQEDALQLYRLAAKLHPINV 395
Cdd:TIGR02917 284 LQDALKSAPeYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIATLSPALGLDPDDP 363

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580641   396 ESLASIAVGYFYDNNPEMALMYYRRILSLGAQSPELYCNIALCCLYGGQIDLVLPCFQRALATATQPGQKSDIwynLSFV 475
Cdd:TIGR02917 364 AALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLDPELGRADLL---LILS 440

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24580641   476 AVTSGDFNLAKRCLQLCLTSDAQNGAALNNLAVLAAQSGDILGAKSYLNAAKDVMPDAAEVTTNLQFMD 544
Cdd:TIGR02917 441 YLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARID 509
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
475-540 8.69e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 35.92  E-value: 8.69e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24580641 475 VAVTSGDFNLAKRCLQLCLTSDAQNGAALNNLAVLAAQSGDILGAKSYlNAAKDVMPDAAEVTTNL 540
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNL 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH