NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|386764801|ref|NP_608395|]
View 

trabuco, isoform C [Drosophila melanogaster]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
 292-466 1.09e-86

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


:

Pssm-ID: 275431  Cd Length: 176  Bit Score: 277.68  E-value: 1.09e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801  292 ATLLYGKNNVQVLPKDVAEPMPGYLSLHQHI-QTLTIKWTPNQLMNGYTEAEEA--EDIDKDAFWAYALNINVDEIVYVH 368
Cdd:cd15784     1 STLLYGKNNVLVQPRDDKEPIKGYLSLHQTGrGNLTLKWTPNQLMNGSSQASSAksNSLDSSVYWDYALSVNLDDIVYIH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801  369 CHQSRgeDSGGTVILVGQDGVQRPPIHFPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILPSVM 448
Cdd:cd15784    81 CHQQD--DSGGTVVLVGQDGVQRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPLWSQRGKGKVLPKLRKRSSLTSSKLS 158

                         170
                  ....*....|....*...
gi 386764801  449 ESVDETPIDYVFRIVSKS 466
Cdd:cd15784   159 EVKEEQATDYVFRIIYPG 176
RUN_SGSM1_like cd17687
RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; ...
 21-214 1.55e-74

RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM1 and SGSM2.


:

Pssm-ID: 439049  Cd Length: 161  Bit Score: 243.73  E-value: 1.55e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801   21 KEVKQLMEEAVTKKYVHEESSSVTSLCGAVEACLSQGLRRRALGLFKTSSTTALLHKIAKSCPEAEHISKLVQEIEASdp 100
Cdd:cd17687     1 KEVKQLMEEAVTRKFIHEDSSSVTSLCGAVDACLLHGLRKRALGLFRSSSTFSLLQKVAKSCPPAADILRKVQEIENL-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801  101 skrsssssdsfqrppMLKKSSSNSMSTGTNaaastssasasisvsaSTSSMSLASMKYLWIRLALYEKRLTKIIEYLVSN 180
Cdd:cd17687    79 ---------------SENKRSSSSSGSNSS----------------NSHGNSSSNRKILWIRIALFEKVLDKIVDYLVEN 127

                         170       180       190
                  ....*....|....*....|....*....|....
gi 386764801  181 ASSFYDRDSLVADSDYGSILSSLLVGPCALEFTR 214
Cdd:cd17687   128 ASKYYEKEALMADPVDGPLLASLLVGPCALDYTK 161
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 923-1087 3.28e-37

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


:

Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 139.36  E-value: 3.28e-37
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801    923 PASSNGGVYSSELLEQFGLN---LHRIEKDVQRCDRNYWYFA---NENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLL 996
Cdd:smart00164   24 DTSADKDLYSRLLKETAPDDksiVHQIEKDLRRTFPEHSFFQdkeGPGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLL 103

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801    997 VIFDDESLSYSCFCKLMERMIENFPSGGAMDMH--FANMRSLIQILDSEMYDLMDSNGDYTHFYfCYRWFLLDFKRELVY 1074
Cdd:smart00164  104 LVMEDEEDAFWCLVKLMERYGPNFYLPDMSGLQldLLQLDRLVKEYDPDLYKHLKDLGITPSLY-ALRWFLTLFARELPL 182

                           170
                    ....*....|...
gi 386764801   1075 DDVFATWEVIWAA 1087
Cdd:smart00164  183 EIVLRIWDVLFAE 195
 
Name Accession Description Interval E-value
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
 292-466 1.09e-86

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


Pssm-ID: 275431  Cd Length: 176  Bit Score: 277.68  E-value: 1.09e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801  292 ATLLYGKNNVQVLPKDVAEPMPGYLSLHQHI-QTLTIKWTPNQLMNGYTEAEEA--EDIDKDAFWAYALNINVDEIVYVH 368
Cdd:cd15784     1 STLLYGKNNVLVQPRDDKEPIKGYLSLHQTGrGNLTLKWTPNQLMNGSSQASSAksNSLDSSVYWDYALSVNLDDIVYIH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801  369 CHQSRgeDSGGTVILVGQDGVQRPPIHFPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILPSVM 448
Cdd:cd15784    81 CHQQD--DSGGTVVLVGQDGVQRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPLWSQRGKGKVLPKLRKRSSLTSSKLS 158

                         170
                  ....*....|....*...
gi 386764801  449 ESVDETPIDYVFRIVSKS 466
Cdd:cd15784   159 EVKEEQATDYVFRIIYPG 176
RUN_SGSM1_like cd17687
RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; ...
 21-214 1.55e-74

RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM1 and SGSM2.


Pssm-ID: 439049  Cd Length: 161  Bit Score: 243.73  E-value: 1.55e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801   21 KEVKQLMEEAVTKKYVHEESSSVTSLCGAVEACLSQGLRRRALGLFKTSSTTALLHKIAKSCPEAEHISKLVQEIEASdp 100
Cdd:cd17687     1 KEVKQLMEEAVTRKFIHEDSSSVTSLCGAVDACLLHGLRKRALGLFRSSSTFSLLQKVAKSCPPAADILRKVQEIENL-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801  101 skrsssssdsfqrppMLKKSSSNSMSTGTNaaastssasasisvsaSTSSMSLASMKYLWIRLALYEKRLTKIIEYLVSN 180
Cdd:cd17687    79 ---------------SENKRSSSSSGSNSS----------------NSHGNSSSNRKILWIRIALFEKVLDKIVDYLVEN 127

                         170       180       190
                  ....*....|....*....|....*....|....
gi 386764801  181 ASSFYDRDSLVADSDYGSILSSLLVGPCALEFTR 214
Cdd:cd17687   128 ASKYYEKEALMADPVDGPLLASLLVGPCALDYTK 161
PH_RBD pfam12068
Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain ...
 293-433 1.17e-55

Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain adopts a Ph-like fold. This domain is found associated with pfam00566.


Pssm-ID: 432305  Cd Length: 149  Bit Score: 189.65  E-value: 1.17e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801   293 TLLYGKNNVQVLPKDVAEPMPGYLSLHQHIQ-TLTIKWTPNQLMNGYTEA-------EEAEDIDKDAFWAYALNINVDEI 364
Cdd:pfam12068    1 RLLYGKNNVFVYPSDIGKPIKGYLSLHQNDKgSVFLKWTPNQLMKSSSQPssassdsEELQSPDGKNPWSWAINVNVKEL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386764801   365 VYVHCHQsRGEDSGGTVILVGQDGVQRPPIHFPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMF 433
Cdd:pfam12068   81 KYIHKHQ-PNEGSPSYIILVTQDGGQFPPLHFPHGGHLLLFLSCLESGLFPVVRLDPPLSRSLSKGKLF 148
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 923-1087 3.28e-37

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 139.36  E-value: 3.28e-37
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801    923 PASSNGGVYSSELLEQFGLN---LHRIEKDVQRCDRNYWYFA---NENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLL 996
Cdd:smart00164   24 DTSADKDLYSRLLKETAPDDksiVHQIEKDLRRTFPEHSFFQdkeGPGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLL 103

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801    997 VIFDDESLSYSCFCKLMERMIENFPSGGAMDMH--FANMRSLIQILDSEMYDLMDSNGDYTHFYfCYRWFLLDFKRELVY 1074
Cdd:smart00164  104 LVMEDEEDAFWCLVKLMERYGPNFYLPDMSGLQldLLQLDRLVKEYDPDLYKHLKDLGITPSLY-ALRWFLTLFARELPL 182

                           170
                    ....*....|...
gi 386764801   1075 DDVFATWEVIWAA 1087
Cdd:smart00164  183 EIVLRIWDVLFAE 195
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 944-1087 1.61e-26

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 107.34  E-value: 1.61e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801   944 HRIEKDVQRCDRNYWYFANE-NLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMER--MIENF 1020
Cdd:pfam00566   10 EQIEKDVPRTFPHSFFFDNGpGQNSLRRILKAYSIYNPDVGYCQGMNFIAAPLLLVYLDEEDAFWCFVSLLENylLRDFY 89

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386764801  1021 PSGGaMDMH--FANMRSLIQILDSEMYDLMDSNGdYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAA 1087
Cdd:pfam00566   90 TPDF-PGLKrdLYVFEELLKKKLPKLYKHLKELG-LDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLE 156
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
 45-218 2.89e-23

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 96.58  E-value: 2.89e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801    45 SLCGAVEACLSQGLRR------RALGLFKTSSTTALLHKIAKSCPEAEHISKLVQEIEAsdpskrsssssdsfqrppmlk 118
Cdd:pfam02759    1 QLCAALEALLSHGLKRssllilRAAGLLPERSFWALLERVGKLVPPAEELLSSVQELEQ--------------------- 59

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801   119 kSSSNSMSTGtnaaastssasasisvsastssmslasMKYLWIRLALYEKRLTKIIEYLVSNA---SSFYDRDSLVADSD 195
Cdd:pfam02759   60 -IHTPYSPDG---------------------------RGRAWIRLALNEKLLDQWLKLLLSNKellSEYYEPWALLADPE 111

                          170       180
                   ....*....|....*....|...
gi 386764801   196 YGSILSSLLVGPCALEFTRAKTA 218
Cdd:pfam02759  112 FGEILLGLLVGLSALDFNLCLKL 134
COG5210 COG5210
GTPase-activating protein [General function prediction only];
943-1086 2.54e-16

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 83.31  E-value: 2.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801  943 LHRIEKDVQRCDRNYWYFANENL---DKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMER---- 1015
Cdd:COG5210   257 ISQIEKDLSRTFPDNSLFQTEISiraENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVLESEEQAFWCLVKLLKNyglp 336

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386764801 1016 -MIENFPSGGAMDMHfaNMRSLIQILDSEMYDLMDSNGDYTHFyFCYRWFLLDFKRELVYDDVFATWEVIWA 1086
Cdd:COG5210   337 gYFLKNLSGLHRDLK--VLDDLVEELDPELYEHLLREGVVLLM-FAFRWFLTLFVREFPLEYALRIWDCLFL 405
RUN smart00593
domain involved in Ras-like GTPase signaling;
157-217 3.66e-15

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 71.11  E-value: 3.66e-15
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 386764801    157 KYLWIRLALYEKRLTKIIEYLVSNA---SSFYDRDSLVADSDYGSILSSLLVGPCALEFTRAKT 217
Cdd:smart00593    1 FRAWIRLALNEKLLSSWLNLLLSDEellSKYYEPWAFLRDPEEGEQLLGLLVGLSALDFNLPVD 64
 
Name Accession Description Interval E-value
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
 292-466 1.09e-86

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


Pssm-ID: 275431  Cd Length: 176  Bit Score: 277.68  E-value: 1.09e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801  292 ATLLYGKNNVQVLPKDVAEPMPGYLSLHQHI-QTLTIKWTPNQLMNGYTEAEEA--EDIDKDAFWAYALNINVDEIVYVH 368
Cdd:cd15784     1 STLLYGKNNVLVQPRDDKEPIKGYLSLHQTGrGNLTLKWTPNQLMNGSSQASSAksNSLDSSVYWDYALSVNLDDIVYIH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801  369 CHQSRgeDSGGTVILVGQDGVQRPPIHFPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILPSVM 448
Cdd:cd15784    81 CHQQD--DSGGTVVLVGQDGVQRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPLWSQRGKGKVLPKLRKRSSLTSSKLS 158

                         170
                  ....*....|....*...
gi 386764801  449 ESVDETPIDYVFRIVSKS 466
Cdd:cd15784   159 EVKEEQATDYVFRIIYPG 176
RUN_SGSM1_like cd17687
RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; ...
 21-214 1.55e-74

RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM1 and SGSM2.


Pssm-ID: 439049  Cd Length: 161  Bit Score: 243.73  E-value: 1.55e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801   21 KEVKQLMEEAVTKKYVHEESSSVTSLCGAVEACLSQGLRRRALGLFKTSSTTALLHKIAKSCPEAEHISKLVQEIEASdp 100
Cdd:cd17687     1 KEVKQLMEEAVTRKFIHEDSSSVTSLCGAVDACLLHGLRKRALGLFRSSSTFSLLQKVAKSCPPAADILRKVQEIENL-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801  101 skrsssssdsfqrppMLKKSSSNSMSTGTNaaastssasasisvsaSTSSMSLASMKYLWIRLALYEKRLTKIIEYLVSN 180
Cdd:cd17687    79 ---------------SENKRSSSSSGSNSS----------------NSHGNSSSNRKILWIRIALFEKVLDKIVDYLVEN 127

                         170       180       190
                  ....*....|....*....|....*....|....
gi 386764801  181 ASSFYDRDSLVADSDYGSILSSLLVGPCALEFTR 214
Cdd:cd17687   128 ASKYYEKEALMADPVDGPLLASLLVGPCALDYTK 161
RUN_SGSM2 cd17704
RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, ...
 21-225 4.19e-57

RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM2.


Pssm-ID: 439066  Cd Length: 180  Bit Score: 195.15  E-value: 4.19e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801   21 KEVKQLMEEAVTKKYVHEESSSVTSLCGAVEACLSQGLRRRALGLFKTSSTTALLHKIAKSCPEAEHISKLVQEIEASDP 100
Cdd:cd17704     1 KEVKQIMEEAVTRKFVHEDSSHIIALCGVVEACLLHLLKRRAAGFLRSDKVAALFTKVGKTYPTAGDICKKVQELQQQVE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801  101 SKRSSSSsdsfQRPPMLKKSSSNSMSTGTNAAastssasasisvsastssmslaSMKYLWIRLALYEKRLTKIIEYLVSN 180
Cdd:cd17704    81 GRKNTQS----TQEELRRQSSTTSKTPPLTPQ----------------------AIKHIWVRTALIEKVLDKIVQYIVDN 134

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 386764801  181 ASSFYDRDSLVADSDYGSILSSLLVGPCALEFTRAKTADHYWTDP 225
Cdd:cd17704   135 CSKYYEKEALMSDPVCGPILASLLVGPCALEYTKLKTADHYWTDP 179
RUN_SGSM1 cd17703
RUN domain found in small G protein signaling modulator 1 (SGSM1) and similar proteins; SGSM1, ...
 21-225 4.42e-56

RUN domain found in small G protein signaling modulator 1 (SGSM1) and similar proteins; SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. This model contains the RUN domain of SGSM1.


Pssm-ID: 439065  Cd Length: 177  Bit Score: 192.15  E-value: 4.42e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801   21 KEVKQLMEEAVTKKYVHEESSSVTSLCGAVEACLSQGLRRRALGLFKTSSTTALLHKIAKSCPEAEHISKLVQEIEA--S 98
Cdd:cd17703     1 KEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLKRRAAGFLRSNKIAALFMKVGKSFPPAEELCRKVQELEQllE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801   99 DPSKRSSSSSDSFQRPPMLKKSSSNSMstgtnaaastssasasisvsastssmslasmKYLWIRLALYEKRLTKIIEYLV 178
Cdd:cd17703    81 NKRNQMQGLQENVRKMPKLPNLSPQAI-------------------------------KHLWIRTALFEKVLDKIVHYLV 129

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 386764801  179 SNASSFYDRDSLVADSDYGSILSSLLVGPCALEFTRAKTADHYWTDP 225
Cdd:cd17703   130 ENSSKYYEKEALLMDPVDGPILASLLVGPCALEYTKMKTADHFWTDP 176
PH_RBD pfam12068
Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain ...
 293-433 1.17e-55

Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain adopts a Ph-like fold. This domain is found associated with pfam00566.


Pssm-ID: 432305  Cd Length: 149  Bit Score: 189.65  E-value: 1.17e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801   293 TLLYGKNNVQVLPKDVAEPMPGYLSLHQHIQ-TLTIKWTPNQLMNGYTEA-------EEAEDIDKDAFWAYALNINVDEI 364
Cdd:pfam12068    1 RLLYGKNNVFVYPSDIGKPIKGYLSLHQNDKgSVFLKWTPNQLMKSSSQPssassdsEELQSPDGKNPWSWAINVNVKEL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386764801   365 VYVHCHQsRGEDSGGTVILVGQDGVQRPPIHFPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMF 433
Cdd:pfam12068   81 KYIHKHQ-PNEGSPSYIILVTQDGGQFPPLHFPHGGHLLLFLSCLESGLFPVVRLDPPLSRSLSKGKLF 148
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 923-1087 3.28e-37

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 139.36  E-value: 3.28e-37
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801    923 PASSNGGVYSSELLEQFGLN---LHRIEKDVQRCDRNYWYFA---NENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLL 996
Cdd:smart00164   24 DTSADKDLYSRLLKETAPDDksiVHQIEKDLRRTFPEHSFFQdkeGPGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLL 103

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801    997 VIFDDESLSYSCFCKLMERMIENFPSGGAMDMH--FANMRSLIQILDSEMYDLMDSNGDYTHFYfCYRWFLLDFKRELVY 1074
Cdd:smart00164  104 LVMEDEEDAFWCLVKLMERYGPNFYLPDMSGLQldLLQLDRLVKEYDPDLYKHLKDLGITPSLY-ALRWFLTLFARELPL 182

                           170
                    ....*....|...
gi 386764801   1075 DDVFATWEVIWAA 1087
Cdd:smart00164  183 EIVLRIWDVLFAE 195
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 944-1087 1.61e-26

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 107.34  E-value: 1.61e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801   944 HRIEKDVQRCDRNYWYFANE-NLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMER--MIENF 1020
Cdd:pfam00566   10 EQIEKDVPRTFPHSFFFDNGpGQNSLRRILKAYSIYNPDVGYCQGMNFIAAPLLLVYLDEEDAFWCFVSLLENylLRDFY 89

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386764801  1021 PSGGaMDMH--FANMRSLIQILDSEMYDLMDSNGdYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAA 1087
Cdd:pfam00566   90 TPDF-PGLKrdLYVFEELLKKKLPKLYKHLKELG-LDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLE 156
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
 45-218 2.89e-23

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 96.58  E-value: 2.89e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801    45 SLCGAVEACLSQGLRR------RALGLFKTSSTTALLHKIAKSCPEAEHISKLVQEIEAsdpskrsssssdsfqrppmlk 118
Cdd:pfam02759    1 QLCAALEALLSHGLKRssllilRAAGLLPERSFWALLERVGKLVPPAEELLSSVQELEQ--------------------- 59

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801   119 kSSSNSMSTGtnaaastssasasisvsastssmslasMKYLWIRLALYEKRLTKIIEYLVSNA---SSFYDRDSLVADSD 195
Cdd:pfam02759   60 -IHTPYSPDG---------------------------RGRAWIRLALNEKLLDQWLKLLLSNKellSEYYEPWALLADPE 111

                          170       180
                   ....*....|....*....|...
gi 386764801   196 YGSILSSLLVGPCALEFTRAKTA 218
Cdd:pfam02759  112 FGEILLGLLVGLSALDFNLCLKL 134
COG5210 COG5210
GTPase-activating protein [General function prediction only];
943-1086 2.54e-16

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 83.31  E-value: 2.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801  943 LHRIEKDVQRCDRNYWYFANENL---DKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMER---- 1015
Cdd:COG5210   257 ISQIEKDLSRTFPDNSLFQTEISiraENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVLESEEQAFWCLVKLLKNyglp 336

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386764801 1016 -MIENFPSGGAMDMHfaNMRSLIQILDSEMYDLMDSNGDYTHFyFCYRWFLLDFKRELVYDDVFATWEVIWA 1086
Cdd:COG5210   337 gYFLKNLSGLHRDLK--VLDDLVEELDPELYEHLLREGVVLLM-FAFRWFLTLFVREFPLEYALRIWDCLFL 405
RUN smart00593
domain involved in Ras-like GTPase signaling;
157-217 3.66e-15

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 71.11  E-value: 3.66e-15
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 386764801    157 KYLWIRLALYEKRLTKIIEYLVSNA---SSFYDRDSLVADSDYGSILSSLLVGPCALEFTRAKT 217
Cdd:smart00593    1 FRAWIRLALNEKLLSSWLNLLLSDEellSKYYEPWAFLRDPEEGEQLLGLLVGLSALDFNLPVD 64
RUN cd17671
RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new ...
 21-213 2.24e-10

RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new molecule containing SH3 at the carboxyl-terminus), is a less conserved protein motif that comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. RUN domains are often found in proteins linked particularly to the functions of GTPases in the Rap and Rab families, suggesting the RUN domain may be involved in Rab-mediated membrane trafficking, possibly as a Rab-binding site. RUN domain-containing proteins could hence play important roles in multiple Ras-like GTPase signalling pathways.


Pssm-ID: 439038  Cd Length: 154  Bit Score: 60.13  E-value: 2.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801   21 KEVKQLMEEAVTKK--------YVHEESSSVTSLCGAVEACLSQGLRRRALGLFKTSsttalLHKIAKSCPEAEHISKLV 92
Cdd:cd17671     1 KAVKELLESFADNGeaddsaalTLTDDDPVVGRLCAALEAILSHGLKPKRFGGGKVS-----FWDFLEALEKLLPAPSLK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801   93 QEIEasdpskrsssssdsfqrppmlkksSSNSMSTGTNaaastssasasisvsastssmslASMKY-LWIRLALYEKRLT 171
Cdd:cd17671    76 QAIR------------------------DINSLSNVKT-----------------------DDGRGrAWIRLALNEKSLE 108

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 386764801  172 KIIEYLVSNAS---SFYDRDSLVADSDYGSILSSLLVGPCALEFT 213
Cdd:cd17671   109 SYLAALLSDQSllrKYYEPWALLRDPEEAELFLSLLVGLSSLDFN 153
RUN_RUNDC3 cd17684
RUN domain found in RUN domain-containing protein 3 (RUNDC3) and similar proteins; RUNDC3 ...
 160-213 1.29e-03

RUN domain found in RUN domain-containing protein 3 (RUNDC3) and similar proteins; RUNDC3 contains two isoforms, RUNDC3A and RUNDC3B. RUNDC3A, also called Rap2-interacting protein 8 (RPIP8), may act as an effector of Rap2A GTPase in neuronal cells. RUNDC3B, also called Rap2-binding protein 9, or Rap2-interacting protein 9 (RPIP-9), contains a RUN domain in its N-terminal region that mediates interaction with Rap2, an important component of the Mitogen-Activated Protein Kinase (MAPK) cascade, which regulates cellular proliferation and differentiation. It also contains characteristic binding sites for MAPK intermediates. Both RUNDC3A and RUNDC3B contain a RUN domain.


Pssm-ID: 439046  Cd Length: 150  Bit Score: 40.46  E-value: 1.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 386764801  160 WIRLALYEKRLTKIIEYLVSNA---SSFYDRDSLVAdSDYGSILSSLLVGPCALEFT 213
Cdd:cd17684    94 WIRVALMEKRLSEYLSTALKQTrltRNFYQDGAIML-SEDATVLCGMLIGLNAIDFS 149
RUN_RUFY1_like cd17681
RUN domain found in RUN and FYVE domain-containing proteins, RUFY1, RUFY2, RUFY3 and similar ...
 13-206 4.13e-03

RUN domain found in RUN and FYVE domain-containing proteins, RUFY1, RUFY2, RUFY3 and similar proteins; This family includes RUN and FYVE domain-containing protein RUFY1, RUFY2, and RUFY3. RUFY1, also called FYVE-finger protein EIP1, or La-binding protein 1, or Rab4-interacting protein (Rabip4), or Zinc finger FYVE domain-containing protein 12 (ZFY12), a human homolog of mouse Rabip4, an effector of Rab4 GTPase that regulates recycling of endocytosed cargo. RUFY1 is an endosomal protein that functions as a dual effector of Rab4 and Rab14 and is involved in efficient recycling of transferrin (Tfn). It is a downstream effector of Etk, a downstream tyrosine kinase of PI3-kinase that is involved in regulation of vesicle trafficking. RUFY2, also called Rab4-interacting protein related, is a novel embryonic factor that is present in the nucleus at early stages of embryonic development. It may have both endosomal functions in the cytoplasm and nuclear functions. RUFY3, also called Rap2-interacting protein x (RIPx or RPIPx), or single axon-regulated protein (singar), is an N-terminal RUN domain and a C-terminal FYVE domain containing protein predominantly expressed in the brain. It suppresses formation of surplus axons for neuronal polarity. Unlike other RUFY proteins, RUFY3 can associate with the GTP-bound active form of Rab5. RUFY1, RUFY2, and RUFY3 contain an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between; this model represents the RUN domain.


Pssm-ID: 439043  Cd Length: 155  Bit Score: 39.09  E-value: 4.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801   13 ER--LIASVKKEVKQLMEEAVTKKYVHEES-SSVTSLCGAVEACLSQGLRRRALGLFKTSSTTALLHKIAKSCPEAEHIS 89
Cdd:cd17681     1 ERrnLLNLAKLSIKELIESALSFGRTLDSDhVPLQQFFVILEHVLRHGLKVKKSFLGPNKSFWPVLEHVEKLVPEANEIT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801   90 KLVQEIeasdpskrsssssdsfqrpPMLKksssnsmsTGTNAAAstssasasisvsastssmslasmkyLWIRLALYEKR 169
Cdd:cd17681    81 ASVRDL-------------------PGIK--------TPLGRAR-------------------------AWLRLALMQKK 108

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 386764801  170 LTKIIEYLVSN---ASSFYDRDSLVAdSDYGSILSSLLVG 206
Cdd:cd17681   109 LADYFRALIENkdlLSEFYEPGALMM-SEEAVVIAGLLVG 147
RUN_RUNDC3A cd17699
RUN domain found in RUN domain-containing protein 3A (RUNDC3A) and similar proteins; RUN ...
 160-213 4.24e-03

RUN domain found in RUN domain-containing protein 3A (RUNDC3A) and similar proteins; RUN domain-containing protein 3A (RUNDC3A), also called Rap2-interacting protein 8 (RPIP8), may act as an effector of Rap2A GTPase in neuronal cells. It contains a RUN domain.


Pssm-ID: 439061  Cd Length: 151  Bit Score: 39.24  E-value: 4.24e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 386764801  160 WIRLALYEKRLTKIIEYLVSNASS---FYDrDSLVADSDYGSILSSLLVGPCALEFT 213
Cdd:cd17699    94 WIRVALMEKRLSEYIATALRDTRTtrrFYD-DGAIMLREESTVLTGMLIGLSAIDFS 149
RUN_RUFY4_like cd17682
RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4), FYVE and coiled-coil ...
 159-204 5.19e-03

RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4), FYVE and coiled-coil domain-containing protein 1 (FYCO1), and similar proteins; The family includes RUFY4 and FYCO1. RUFY4 acts as a positive regulator that enhances autophagy and lysosome tethering in response to Interleukin-4. It is expressed in a cell-specific manner or under specific immunological conditions associated with IL4 expression such as allergic asthma. FYCO1, also called zinc finger FYVE domain-containing protein 7 (ZFYVE7), is a multidomain autophagy adaptor protein that interacts with kinesin motor proteins and with the autophagosomal membrane components microtubule-associated protein 1 light chain 3 (LC3), Rab7, and phosphatidylinositol 3-phosphate (PI3P), to mediate microtubule plus-end-directed autophagosome transport. Both RUFY4 and FYCO1 contain an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between; this model represents the RUN domain.


Pssm-ID: 439044  Cd Length: 150  Bit Score: 38.75  E-value: 5.19e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 386764801  159 LWIRLALYEKRLTKIIEYLVSN---ASSFYDRDSLVADSDYGSILSSLL 204
Cdd:cd17682    92 LFIRYALNKKCLHDPVQQLVKNpklLSDYYSPDSILGNEILSEILLSLL 140
PH-like cd00900
Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like ...
 298-409 8.15e-03

Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like and IRS-like PTB domains, the ran-binding domain, the EVH1 domain, a domain in neurobeachin and the third domain of FERM. All of these domains have a PH fold, but lack significant sequence similarity. They are generally involved in targeting to protein to the appropriate cellular location or interacting with a binding partner. This domain family possesses multiple functions including the ability to bind inositol phosphates and to other proteins.


Pssm-ID: 275390  Cd Length: 89  Bit Score: 36.61  E-value: 8.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386764801  298 KNNVQVLPKDVAEPMPGYLSLHQHiqtlTIKWTPNQLMNgyteaeeaedidkdafwaYALNINVDEIVYVHChqSRGEDS 377
Cdd:cd00900     2 KFRAVRVYREPTKRVEGTLYITSD----RLILRDKNDGG------------------LELSIPISDIVNVNV--SPQGPS 57

                          90       100       110
                  ....*....|....*....|....*....|..
gi 386764801  378 GGTVILVGQDGVQRPPIHFPEGGHMQQFLSCL 409
Cdd:cd00900    58 SRYLVLVLKDRGEFVGFSFPKEEDAIEISDAL 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH