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Conserved domains on  [gi|238624134|ref|NP_599010|]
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T-cell immunoglobulin and mucin domain-containing protein 2 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_TIM-3_like cd20982
Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3) ...
 23-128 2.83e-63

Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3), and similar domains; The members here are composed of the immunoglobulin variable (IgV) domain of T cell immunoglobulin domain and mucin domain 3 (Tim-3; also known as Hepatitis A virus cellular receptor 2 (HAVcr-2) and Cluster of Differentiation 366 (CD366)) and similar proteins. TIM-3 is a checkpoint inhibitor in immune responses to tumors, as well as involved in chronic viral infections. Thus, Tim-3 has emerged as one of most promising immune checkpoint targets for cancer immunotherapy. Tim-3 is highly expressed on Th1 lymphocytes and CD11b(+) macrophages and is upregulated on activated T and myeloid cells. TIM-3 regulates macrophage, activation and inhibits Th1 mediated immune responses to promote immunological tolerance. There are three TIM family members in humans (TIM-1, TIM-3, and TIM-4) and eight members in mice (TIM-1 to TIM-8). The IgV domain of human TIM-3 has been shown to bind ligands such as carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1), high mobility group protein B1 (HMGB1)and galectin-9 (GAL9). The binding of GAL9 to TIM-3 can negatively regulate Th1 immune response, enhance immune tolerance and inhibit anti#tumor immunity. Dysregulation of the TIM-3/GAL9 pathway is implicated in numerous chronic autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus.


:

Pssm-ID: 409574  Cd Length: 107  Bit Score: 194.98  E-value: 2.83e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624134  23 TAVQGLAGHPVTLPCIYSTHLGG-IVPMCWGLGECRHSYCIRSLIWTNGYTVTHQRNSRYQLKGNISEGNVSLTIENTVV 101
Cdd:cd20982    1 VEYRAEVGHNAYLPCSYTTAAPGnLVPVCWGKGACPVSYCGNVLLRTDERDVTYQKSSRYQLKGDFSKGDVSLTIENVTL 80

                         90       100
                 ....*....|....*....|....*..
gi 238624134 102 GDGGPYCCVVEIPGAFHFVDYMLEVKP 128
Cdd:cd20982   81 ADSGIYCCRIQIPGIMNDEKFNLKLVI 107
 
Name Accession Description Interval E-value
IgV_TIM-3_like cd20982
Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3) ...
 23-128 2.83e-63

Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3), and similar domains; The members here are composed of the immunoglobulin variable (IgV) domain of T cell immunoglobulin domain and mucin domain 3 (Tim-3; also known as Hepatitis A virus cellular receptor 2 (HAVcr-2) and Cluster of Differentiation 366 (CD366)) and similar proteins. TIM-3 is a checkpoint inhibitor in immune responses to tumors, as well as involved in chronic viral infections. Thus, Tim-3 has emerged as one of most promising immune checkpoint targets for cancer immunotherapy. Tim-3 is highly expressed on Th1 lymphocytes and CD11b(+) macrophages and is upregulated on activated T and myeloid cells. TIM-3 regulates macrophage, activation and inhibits Th1 mediated immune responses to promote immunological tolerance. There are three TIM family members in humans (TIM-1, TIM-3, and TIM-4) and eight members in mice (TIM-1 to TIM-8). The IgV domain of human TIM-3 has been shown to bind ligands such as carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1), high mobility group protein B1 (HMGB1)and galectin-9 (GAL9). The binding of GAL9 to TIM-3 can negatively regulate Th1 immune response, enhance immune tolerance and inhibit anti#tumor immunity. Dysregulation of the TIM-3/GAL9 pathway is implicated in numerous chronic autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus.


Pssm-ID: 409574  Cd Length: 107  Bit Score: 194.98  E-value: 2.83e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624134  23 TAVQGLAGHPVTLPCIYSTHLGG-IVPMCWGLGECRHSYCIRSLIWTNGYTVTHQRNSRYQLKGNISEGNVSLTIENTVV 101
Cdd:cd20982    1 VEYRAEVGHNAYLPCSYTTAAPGnLVPVCWGKGACPVSYCGNVLLRTDERDVTYQKSSRYQLKGDFSKGDVSLTIENVTL 80

                         90       100
                 ....*....|....*....|....*..
gi 238624134 102 GDGGPYCCVVEIPGAFHFVDYMLEVKP 128
Cdd:cd20982   81 ADSGIYCCRIQIPGIMNDEKFNLKLVI 107
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 30-119 1.04e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 52.08  E-value: 1.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624134   30 GHPVTLPCIYST-HLGGIVPMCWGLGEC--RHSYCIrsLIWTNGYTVTHQRNsRYQLKGNISEGNVSLTIENTVVGDGGP 106
Cdd:pfam07686  11 GGSVTLPCTYSSsMSEASTSVYWYRQPPgkGPTFLI--AYYSNGSEEGVKKG-RFSGRGDPSNGDGSLTIQNLTLSDSGT 87

                          90
                  ....*....|...
gi 238624134  107 YCCVVEIPGAFHF 119
Cdd:pfam07686  88 YTCAVIPSGEGVF 100
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 25-126 3.57e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.64  E-value: 3.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624134    25 VQGLAGHPVTLPCIYSthlGGIVPMCWglgecrhsycirsliWTNGYTVTHQRNSRYQLKGNisEGNVSLTIENTVVGDG 104
Cdd:smart00410   4 VTVKEGESVTLSCEAS---GSPPPEVT---------------WYKQGGKLLAESGRFSVSRS--GSTSTLTISNVTPEDS 63

                           90       100
                   ....*....|....*....|..
gi 238624134   105 GPYCCVVEIPGAFHFVDYMLEV 126
Cdd:smart00410  64 GTYTCAATNSSGSASSGTTLTV 85
 
Name Accession Description Interval E-value
IgV_TIM-3_like cd20982
Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3) ...
 23-128 2.83e-63

Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3), and similar domains; The members here are composed of the immunoglobulin variable (IgV) domain of T cell immunoglobulin domain and mucin domain 3 (Tim-3; also known as Hepatitis A virus cellular receptor 2 (HAVcr-2) and Cluster of Differentiation 366 (CD366)) and similar proteins. TIM-3 is a checkpoint inhibitor in immune responses to tumors, as well as involved in chronic viral infections. Thus, Tim-3 has emerged as one of most promising immune checkpoint targets for cancer immunotherapy. Tim-3 is highly expressed on Th1 lymphocytes and CD11b(+) macrophages and is upregulated on activated T and myeloid cells. TIM-3 regulates macrophage, activation and inhibits Th1 mediated immune responses to promote immunological tolerance. There are three TIM family members in humans (TIM-1, TIM-3, and TIM-4) and eight members in mice (TIM-1 to TIM-8). The IgV domain of human TIM-3 has been shown to bind ligands such as carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1), high mobility group protein B1 (HMGB1)and galectin-9 (GAL9). The binding of GAL9 to TIM-3 can negatively regulate Th1 immune response, enhance immune tolerance and inhibit anti#tumor immunity. Dysregulation of the TIM-3/GAL9 pathway is implicated in numerous chronic autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus.


Pssm-ID: 409574  Cd Length: 107  Bit Score: 194.98  E-value: 2.83e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624134  23 TAVQGLAGHPVTLPCIYSTHLGG-IVPMCWGLGECRHSYCIRSLIWTNGYTVTHQRNSRYQLKGNISEGNVSLTIENTVV 101
Cdd:cd20982    1 VEYRAEVGHNAYLPCSYTTAAPGnLVPVCWGKGACPVSYCGNVLLRTDERDVTYQKSSRYQLKGDFSKGDVSLTIENVTL 80

                         90       100
                 ....*....|....*....|....*..
gi 238624134 102 GDGGPYCCVVEIPGAFHFVDYMLEVKP 128
Cdd:cd20982   81 ADSGIYCCRIQIPGIMNDEKFNLKLVI 107
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 30-119 1.04e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 52.08  E-value: 1.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624134   30 GHPVTLPCIYST-HLGGIVPMCWGLGEC--RHSYCIrsLIWTNGYTVTHQRNsRYQLKGNISEGNVSLTIENTVVGDGGP 106
Cdd:pfam07686  11 GGSVTLPCTYSSsMSEASTSVYWYRQPPgkGPTFLI--AYYSNGSEEGVKKG-RFSGRGDPSNGDGSLTIQNLTLSDSGT 87

                          90
                  ....*....|...
gi 238624134  107 YCCVVEIPGAFHF 119
Cdd:pfam07686  88 YTCAVIPSGEGVF 100
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 25-126 3.57e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.64  E-value: 3.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624134    25 VQGLAGHPVTLPCIYSthlGGIVPMCWglgecrhsycirsliWTNGYTVTHQRNSRYQLKGNisEGNVSLTIENTVVGDG 104
Cdd:smart00410   4 VTVKEGESVTLSCEAS---GSPPPEVT---------------WYKQGGKLLAESGRFSVSRS--GSTSTLTISNVTPEDS 63

                           90       100
                   ....*....|....*....|..
gi 238624134   105 GPYCCVVEIPGAFHFVDYMLEV 126
Cdd:smart00410  64 GTYTCAATNSSGSASSGTTLTV 85
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 83-112 4.13e-03

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 36.40  E-value: 4.13e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 238624134  83 LKGNISEGNVSLTIENTVVGDGGPYCCVVE 112
Cdd:cd05713   70 LKDAIAEGSVALRIHNVRPSDEGQYTCFFR 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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