BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQRIYGDGTGGSVVLPAGFAEIFGLLLDFFYTGHLAL 87
Cdd:cd18232    1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGSVVLPESFAEVFGLLLDFFYTGELAL 80

                         90       100
                 ....*....|....*....|....*...
gi 126366001  88 TSGNRDQVLLAAKELRVPEAVELCQSFQ 115
Cdd:cd18232   81 TRENRDRVLLAAKELRVPEAVELCQRFQ 108

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001 367 GEMPYKCS--SCSQQFMQKKDLQSHMIKLHGAPKPHACPTCAKcflsrtelqlHEAFKHRgEKLFVCEECGHRASSRNGL 444
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHGHQNQKLHENPSPEK----------MNIFSAK-DKPYRCEVCDKRYKNLNGL 414

                 ....*...
gi 126366001 445 QMHIKAKH 452
Cdd:COG5189  415 KYHRKHSH 422

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 126366001  571 FECTECGYKFTRQAHLRRHMEIH 593
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQRIYGDGTGGSVVLPAGFAEIFGLLLDFFYTGHLAL 87
Cdd:cd18232    1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGSVVLPESFAEVFGLLLDFFYTGELAL 80

                         90       100
                 ....*....|....*....|....*...
gi 126366001  88 TSGNRDQVLLAAKELRVPEAVELCQSFQ 115
Cdd:cd18232   81 TRENRDRVLLAAKELRVPEAVELCQRFQ 108

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001    27 DATLDVGGLVFKAHWSVLACCSHFFQRIYGDGTGGS----VVLPAGFAEIFGLLLDFFYTGHLALTSGNRDQVLLAAKEL 102
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESdkseIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 126366001   103 RVPEAVELCQSFQPQTS 119
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001 367 GEMPYKCS--SCSQQFMQKKDLQSHMIKLHGAPKPHACPTCAKcflsrtelqlHEAFKHRgEKLFVCEECGHRASSRNGL 444
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHGHQNQKLHENPSPEK----------MNIFSAK-DKPYRCEVCDKRYKNLNGL 414

                 ....*...
gi 126366001 445 QMHIKAKH 452
Cdd:COG5189  415 KYHRKHSH 422

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....
gi 126366001  298 YLKVHNRKHTGEKPFECPKCGKCY 321
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*
gi 126366001  558 LRVHVRRHKGVRKFECTECGYKFTR 582
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26

hypothetical protein

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 126366001 457 PYVCEFCSHAFTQKANLNMHLRTHTGEKpfQCHLCGKTFR-TQASLD----KHN 505
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRnTDSTLDhvckKHN 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQRIYGDGTGGSVVLPAGFAEIFGLLLDFFYTGHLAL 87
Cdd:cd18232    1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGSVVLPESFAEVFGLLLDFFYTGELAL 80

                         90       100
                 ....*....|....*....|....*...
gi 126366001  88 TSGNRDQVLLAAKELRVPEAVELCQSFQ 115
Cdd:cd18232   81 TRENRDRVLLAAKELRVPEAVELCQRFQ 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001   7 QHSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQRIYGDG---TGGSVVLPAGF-AEIFGLLLDFFYT 82
Cdd:cd18256    2 KHASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGmseSSKDVVQIHGVePDIFHILLDFIYT 81

                         90       100       110
                 ....*....|....*....|....*....|..
gi 126366001  83 GHLALTSGNRDQVLLAAKELRVPEAVELCQSF 114
Cdd:cd18256   82 GVVEVTVSNVQELLVAADMLQLTEVVEICCEF 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001   5 FVQHSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQRIYGDGTGGS--VVLPAGF--AEIFGLLLDFF 80
Cdd:cd18198    5 FPDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDqqNVYEIDFvsPEALTALLEFA 84

                         90       100       110
                 ....*....|....*....|....*....|.
gi 126366001  81 YTGHLALTSGNRDQVLLAAKELRVPEAVELC 111
Cdd:cd18198   85 YTATLTVSTANVGDILSAARLLEIPCVSHVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQRIYGDGTGGSVVLPAG--FAEIFGLLLDFFYTGHL 85
Cdd:cd18217    1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDNIVFLDQSqvSADGFQKLLEFIYTGNL 80

                         90       100
                 ....*....|....*....|....*..
gi 126366001  86 ALTSGNRDQVLLAAKELRVPEAVELCQ 112
Cdd:cd18217   81 NLDSWNVAEIHQAASYLGMEEVVAKCK 107

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001    27 DATLDVGGLVFKAHWSVLACCSHFFQRIYGDGTGGS----VVLPAGFAEIFGLLLDFFYTGHLALTSGNRDQVLLAAKEL 102
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESdkseIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 126366001   103 RVPEAVELCQSFQPQTS 119
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQRIYGDGTGGS---------VVLPAGFAEIfgllLD 78
Cdd:cd18230    4 HYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSdqatvthldIVTAQGFKAI----ID 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 126366001  79 FFYTGHLALTSGNRDQVLLAAKELRVPEAVELCQSF 114
Cdd:cd18230   80 FMYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNF 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001   5 FVQHSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQRIYgdgTGGSVVLPAGFAEI-------FGLLL 77
Cdd:cd18326    5 FPDHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLF---TSGAVVDQQNVYEIdfvsaeaLTALL 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 126366001  78 DFFYTGHLALTSGNRDQVLLAAKELRVPEAVELC 111
Cdd:cd18326   82 DFAYTATLTVSTSNVGDILSAARLLEIPAVSHVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQRIY---GDGTGGSVV-LPAGFAEIFGLLLDFFYTG 83
Cdd:cd18306    1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFssdSDGESILTVkLDGLDPDAVEVLVNYAYTS 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 126366001  84 HLALTSGNRDQVLLAAKELRVPEAVELCQSF 114
Cdd:cd18306   81 RLEVPADLVKSVYSAAKKLKMDRVKKACGDF 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001   7 QHSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQRIYGDGTGGSV---VLPAGF-AEIFGLLLDFFYT 82
Cdd:cd18332    1 RHSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVsvlTLPSGLeARGFQLLLDFMYT 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 126366001  83 GHLALTSGNRDQVLLAAKELRVPEAVELCQSF 114
Cdd:cd18332   81 SRLPLTPRTVPAVLAAATYLQMEHVVETCRRF 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFF-----QRIYGDGTGGSVVLPAGFAEIFGLLLDFFYT 82
Cdd:cd18199    1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFrmllsHYIQDTGRPSTASFDVFSSDAFSIILDFVYS 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 126366001  83 GHLALTSGNRDQVLLAAKELRVPEAVELCQSF 114
Cdd:cd18199   81 GKLSLTSQNVIEVMSAASYLQMTDVINVCKTF 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001   5 FVQHSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQRIYGDGTGGS----------VVLPAgfaeiFG 74
Cdd:cd18956    3 FPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGGrdtvrlngdiVTAPA-----FG 77

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 126366001  75 LLLDFFYTGHLALTSGNRDQVLLAAKELRVPEAVELCQ 112
Cdd:cd18956   78 RLLDFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCK 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQRIYGD--GTGGSV-VLPAGFAEIFGLLLDFFYTGH 84
Cdd:cd18212    6 HKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADegEVGQSIyMLEGMVAETFGALLEFIYTGC 85

                         90       100       110
                 ....*....|....*....|....*....|.
gi 126366001  85 LALTSGNRDQVLLAAKELRVPEAVELCQSFQ 115
Cdd:cd18212   86 LQVGEKSLEQILATAQFLKVNDLVKAYSDYQ 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQRIYGDGTG-GSVVLPAGFAEIFGL--LLDFFYTGH 84
Cdd:cd18233    1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSqKNDVFHLDIKNVGGIgqILDFMYTSH 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 126366001  85 LALTSGNRDQVLLAAKELRVPEAVELCQSF 114
Cdd:cd18233   81 LDLNQDNVQVMLDIAQCLQVQNVLNMCYTF 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001  11 RVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQR-----IYGDGTGGSVVLPAGFAEIFGLLLDFFYTGHL 85
Cdd:cd18330    4 KLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRAllihyIQDSGRHSTASLDIVTSEAFSIILDFLYSGKL 83

                         90       100
                 ....*....|....*....|....*....
gi 126366001  86 ALTSGNRDQVLLAAKELRVPEAVELCQSF 114
Cdd:cd18330   84 DLCSENVIEVMSAASYLQMTDVVNFCKGY 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001   5 FVQHSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQRIYGDG---------TGGSVVLPAgfaeiFGL 75
Cdd:cd18324    3 FPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQldkrdivhlNSDIVTAPA-----FAL 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 126366001  76 LLDFFYTGHLALTSGNRDQVLLAAKELRVPEAVELCQSFQPQTSVGQAQS 125
Cdd:cd18324   78 LLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKATTEADS 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQRIYGDGTGGSVVL--PAGFAEI---------FGLL 76
Cdd:cd18228    2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLvsPAGKCVLdlhhvtvtgFAPL 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 126366001  77 LDFFYTGHLALTSGNRDQVLLAAKELRVPEAVELCQSF 114
Cdd:cd18228   82 LEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEF 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001   5 FVQHSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQRIYGDGTGGS--------VVLPAGFAEIfgll 76
Cdd:cd18328    5 FPNHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADqpyvyeidFVTPEALSAI---- 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 126366001  77 LDFFYTGHLALTSGNRDQVLLAAKELRVPEAVELC 111
Cdd:cd18328   81 LEFAYTSTLTITTSNVKHILNAAQMLEIQCIINVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQRIYGDGTGGS--------VVLPAGFAEIfgllLDF 79
Cdd:cd18264   11 HGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESkarvihlpVVSAAGLQRV----LDF 86

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 126366001  80 FYTGHLALTSGNRDQVLLAAKELRVPEAVELCQSF 114
Cdd:cd18264   87 IYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQY 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQRIYGDG---TGGSVVLPAGfAEIFGL--LLDFFYT 82
Cdd:cd18266    8 HSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGmreAHQKEVELVG-ASYIGLkaVIDFLYS 86

                         90       100
                 ....*....|....*....|....*....
gi 126366001  83 GHLALTSGNRDQVLLAAKELRVPEAVELC 111
Cdd:cd18266   87 SELPLDGGNIDYVLETAHLLQIWKVVDFC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126366001   8 HSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQR-------IYGDGTGGSvvlpagfAEIFGLLLDFF 80
Cdd:cd18216    3 HATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSlvlhdnlIHLDQDMVS-------PTVFQQILDFI 75

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 126366001  81 YTGHLA---LTSGNRDQVLLAAKELRVPEAVELCQS 113
Cdd:cd18216   76 YTGKLLdslFEEPNLSEVLAAANYLQLPDLAALCRS 111