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Conserved domains on  [gi|19527092|ref|NP_598639|]
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regulator of chromosome condensation isoform 2 [Mus musculus]

Protein Classification

RCC1 domain-containing protein( domain architecture ID 11474102)

RCC1 (regulator of chromosome condensation) domain-containing protein similar to Arabidopsis UVR8 (UV RESISTANCE LOCUS 8), which plays an important role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway.

Gene Ontology:  GO:0003682|GO:0005085
PubMed:  9510255|18442486

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 32-389 2.12e-53

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 181.33  E-value: 2.12e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527092  32 TEPGLVLTLGQGDVGQLGLGESVlERKKPALVPLLQDVVQAEAGGMHTVCLSQSGQVYSFGCNDEGALGRDTSVEGSemV 111
Cdd:COG5184  14 KSDGTVWCWGDNSYGQLGDGTTT-DRSTPVRVPGLSNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRT--T 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527092 112 PGKVELQEKVVQVSAGDSHTAALTEDGRVFLWGSfrDNNGVIGLLEPMKKSmVPVQVQLDA-PVVKVASGNDHLVMLTND 190
Cdd:COG5184  91 PVKVPGLTGVVAVAAGYYHSCALKSDGTVWCWGD--NSSGQLGDGTTTNRL-TPVQVDAGLsGVVAIAAGGYHTCALKSD 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527092 191 GDLYTLGCGEQGQLGRVpelfanrggrqGLGRLLVPRCVllksRGTRGrvrFQDAFCGAYFTFAISREGHVYGFGLSNYH 270
Cdd:COG5184 168 GTVWCWGANSYGQLGDG-----------TTTDRPTPVQV----GGLSG---VVAVAAGGDHSCALKSDGTVWCWGSNSSG 229

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527092 271 QLGTPGTGSCFIPQNLTSFKNstksWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGeGAEEKSIPTLISRLPVVSSV 350
Cdd:COG5184 230 QLGDGTTTDRATPVQVAGLTG----VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDG-TTTDRSTPVKVPGLSGVVAV 304

                       330       340       350
                ....*....|....*....|....*....|....*....
gi 19527092 351 ACGASVGYAVSKDGRVFAWGMGTNYQLGTGQDEDAWSPV 389
Cdd:COG5184 305 AAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTPV 343
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 32-389 2.12e-53

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 181.33  E-value: 2.12e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527092  32 TEPGLVLTLGQGDVGQLGLGESVlERKKPALVPLLQDVVQAEAGGMHTVCLSQSGQVYSFGCNDEGALGRDTSVEGSemV 111
Cdd:COG5184  14 KSDGTVWCWGDNSYGQLGDGTTT-DRSTPVRVPGLSNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRT--T 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527092 112 PGKVELQEKVVQVSAGDSHTAALTEDGRVFLWGSfrDNNGVIGLLEPMKKSmVPVQVQLDA-PVVKVASGNDHLVMLTND 190
Cdd:COG5184  91 PVKVPGLTGVVAVAAGYYHSCALKSDGTVWCWGD--NSSGQLGDGTTTNRL-TPVQVDAGLsGVVAIAAGGYHTCALKSD 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527092 191 GDLYTLGCGEQGQLGRVpelfanrggrqGLGRLLVPRCVllksRGTRGrvrFQDAFCGAYFTFAISREGHVYGFGLSNYH 270
Cdd:COG5184 168 GTVWCWGANSYGQLGDG-----------TTTDRPTPVQV----GGLSG---VVAVAAGGDHSCALKSDGTVWCWGSNSSG 229

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527092 271 QLGTPGTGSCFIPQNLTSFKNstksWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGeGAEEKSIPTLISRLPVVSSV 350
Cdd:COG5184 230 QLGDGTTTDRATPVQVAGLTG----VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDG-TTTDRSTPVKVPGLSGVVAV 304

                       330       340       350
                ....*....|....*....|....*....|....*....
gi 19527092 351 ACGASVGYAVSKDGRVFAWGMGTNYQLGTGQDEDAWSPV 389
Cdd:COG5184 305 AAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTPV 343
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
363-414 1.56e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 59.07  E-value: 1.56e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 19527092   363 DGRVFAWGMGTNYQLGTGQDEDAWSPVEMTGkqLENRVVLTVSSGGQHTVLL 414
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEG--LSGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 32-389 2.12e-53

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 181.33  E-value: 2.12e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527092  32 TEPGLVLTLGQGDVGQLGLGESVlERKKPALVPLLQDVVQAEAGGMHTVCLSQSGQVYSFGCNDEGALGRDTSVEGSemV 111
Cdd:COG5184  14 KSDGTVWCWGDNSYGQLGDGTTT-DRSTPVRVPGLSNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRT--T 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527092 112 PGKVELQEKVVQVSAGDSHTAALTEDGRVFLWGSfrDNNGVIGLLEPMKKSmVPVQVQLDA-PVVKVASGNDHLVMLTND 190
Cdd:COG5184  91 PVKVPGLTGVVAVAAGYYHSCALKSDGTVWCWGD--NSSGQLGDGTTTNRL-TPVQVDAGLsGVVAIAAGGYHTCALKSD 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527092 191 GDLYTLGCGEQGQLGRVpelfanrggrqGLGRLLVPRCVllksRGTRGrvrFQDAFCGAYFTFAISREGHVYGFGLSNYH 270
Cdd:COG5184 168 GTVWCWGANSYGQLGDG-----------TTTDRPTPVQV----GGLSG---VVAVAAGGDHSCALKSDGTVWCWGSNSSG 229

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527092 271 QLGTPGTGSCFIPQNLTSFKNstksWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGeGAEEKSIPTLISRLPVVSSV 350
Cdd:COG5184 230 QLGDGTTTDRATPVQVAGLTG----VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDG-TTTDRSTPVKVPGLSGVVAV 304

                       330       340       350
                ....*....|....*....|....*....|....*....
gi 19527092 351 ACGASVGYAVSKDGRVFAWGMGTNYQLGTGQDEDAWSPV 389
Cdd:COG5184 305 AAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTPV 343
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 70-417 7.05e-52

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 177.48  E-value: 7.05e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527092  70 VQAEAGGMHTVCLSQSGQVYSFGCNDEGALGRDTSVEGSemVPGKVELQEKVVQVSAGDSHTAALTEDGRVFLWGSfrDN 149
Cdd:COG5184   1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRS--TPVRVPGLSNVVAVAAGGDHTCALKADGTVWCWGN--NS 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527092 150 NGVIGLLEPmKKSMVPVQVQLDAPVVKVASGNDHLVMLTNDGDLYTLGCGEQGQLGRvpelfANRGGRqglgrlLVPRCV 229
Cdd:COG5184  77 YGQLGDGTT-TDRTTPVKVPGLTGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGD-----GTTTNR------LTPVQV 144

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527092 230 LLksrgtrGRVRFQDAFCGAYFTFAISREGHVYGFGLSNYHQLGTPGTGSCFIPQNLTSFKNstksWVGFSGGQHHTVCM 309
Cdd:COG5184 145 DA------GLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSG----VVAVAAGGDHSCAL 214

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527092 310 DSEGKAYSLGRAEYGRLGLGeGAEEKSIPTLISRLPVVSSVACGASVGYAVSKDGRVFAWGMGTNYQLGTGQDEDAWSPV 389
Cdd:COG5184 215 KSDGTVWCWGSNSSGQLGDG-TTTDRATPVQVAGLTGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPV 293

                       330       340
                ....*....|....*....|....*...
gi 19527092 390 EMTGkqLENrvVLTVSSGGQHTVLLVKD 417
Cdd:COG5184 294 KVPG--LSG--VVAVAAGSSHTCALLTD 317
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
363-414 1.56e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 59.07  E-value: 1.56e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 19527092   363 DGRVFAWGMGTNYQLGTGQDEDAWSPVEMTGkqLENRVVLTVSSGGQHTVLL 414
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEG--LSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
85-134 1.41e-10

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 56.37  E-value: 1.41e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 19527092    85 SGQVYSFGCNDEGALGRDTSVegSEMVPGKVEL--QEKVVQVSAGDSHTAAL 134
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTE--NVLVPQKVEGlsGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
258-309 1.37e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 50.59  E-value: 1.37e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 19527092   258 EGHVYGFGLSNYHQLGTPGTGSCFIPQNLTSFKNstKSWVGFSGGQHHTVCM 309
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSG--NKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
35-82 8.98e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 45.59  E-value: 8.98e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 19527092    35 GLVLTLGQGDVGQLGLGeSVLERKKPALVPLLQD--VVQAEAGGMHTVCL 82
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLG-TTENVLVPQKVEGLSGnkVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
121-145 1.15e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 44.72  E-value: 1.15e-06
                          10        20
                  ....*....|....*....|....*
gi 19527092   121 VVQVSAGDSHTAALTEDGRVFLWGS 145
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGD 25
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
190-255 1.94e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 41.73  E-value: 1.94e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19527092   190 DGDLYTLGCGEQGQLGRVPElfANRggrqglgrlLVPRCVllksrGTRGRVRFQDAFCGAYFTFAI 255
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTT--ENV---------LVPQKV-----EGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
312-355 9.44e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 39.81  E-value: 9.44e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 19527092   312 EGKAYSLGRAEYGRLGLGEGaEEKSIPTLISRLPV--VSSVACGAS 355
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTT-ENVLVPQKVEGLSGnkVVQVACGGD 45
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
137-187 1.44e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 39.04  E-value: 1.44e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 19527092   137 DGRVFLWGsfRDNNGVIGlLEPMKKSMVPVQVQL--DAPVVKVASGNDHLVML 187
Cdd:pfam00415   1 DGRVYTWG--RNDYGQLG-LGTTENVLVPQKVEGlsGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
69-97 9.90e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 36.25  E-value: 9.90e-04
                          10        20
                  ....*....|....*....|....*....
gi 19527092    69 VVQAEAGGMHTVCLSQSGQVYSFGCNDEG 97
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYG 29
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
347-376 1.50e-03

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 35.86  E-value: 1.50e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 19527092   347 VSSVACGASVGYAVSKDGRVFAWGMGTNYQ 376
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
247-271 3.10e-03

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 35.09  E-value: 3.10e-03
                          10        20
                  ....*....|....*....|....*
gi 19527092   247 CGAYFTFAISREGHVYGFGLSNYHQ 271
Cdd:pfam13540   6 AGDNHTLALTSDGRVYCWGDNSYGQ 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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