NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|19424248|ref|NP_598247|]
View 

gonadotropin inducible ovarian transcription factor 1 [Rattus norvegicus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003700|GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217
PubMed:  22803940|8183940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 7.13e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.21  E-value: 7.13e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 19424248     4 VTYEDVYVSFTQEEWALLNPSQKNLYKDVMMQTCRNLIAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
258-654 4.58e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 4.58e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424248 258 KPYKCNQCGKAFASRHNLKMHERIHTGEKPYTCNQ--CGKAFTLYTNLRKHEKIHTGEKPYECS-QCGKAFARRNELQVH 334
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424248 335 ERIHTGEKPYECSQCGKAFASRSNLQTHERTHTGEKPYLCNQCGKAFAWR----RLLQIHERIHTGEKPYacnqcgkaft 410
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnSLHPPLPANSLSKDPS---------- 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424248 411 HFPSLHNHKKIHTGEKPYTCNECGKAFAHLTSFHNHKKIHTGEKPYGCKQCGKAFSFRSNLQIHETAHKGEKPHECNQCG 490
Cdd:COG5048 182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424248 491 KAF--------AHIVYLQRHERSHGDKPYECNQCGKGFTHFGRLKNHLKS--HTGE--KPYEC--NQCGKVFAYRNNLQK 556
Cdd:COG5048 262 RSSlptassqsSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKR 341

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424248 557 HERTHTGEKPYvcdqcgkafasRCNLQKHEKIHTQEKPYVCNQcgkafasrcNFQVHERIHTGEKSY-SYNQCGKDFVSQ 635
Cdd:COG5048 342 HILLHTSISPA-----------KEKLLNSSSKFSPLLNNEPPQ---------SLQQYKDLKNDKKSEtLSNSCIRNFKRD 401

                       410
                ....*....|....*....
gi 19424248 636 SNLQKHEGKHTGEVTYGCD 654
Cdd:COG5048 402 SNLSLHIITHLSFRPYNCK 420
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 7.13e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.21  E-value: 7.13e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 19424248     4 VTYEDVYVSFTQEEWALLNPSQKNLYKDVMMQTCRNLIAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-46 3.56e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.71  E-value: 3.56e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 19424248      4 VTYEDVYVSFTQEEWALLNPSQKNLYKDVMMQTCRNLIAIGYK 46
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 6.31e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 71.81  E-value: 6.31e-16
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 19424248   4 VTYEDVYVSFTQEEWALLNPSQKNLYKDVMMQTCRNLI 41
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
258-654 4.58e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 4.58e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424248 258 KPYKCNQCGKAFASRHNLKMHERIHTGEKPYTCNQ--CGKAFTLYTNLRKHEKIHTGEKPYECS-QCGKAFARRNELQVH 334
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424248 335 ERIHTGEKPYECSQCGKAFASRSNLQTHERTHTGEKPYLCNQCGKAFAWR----RLLQIHERIHTGEKPYacnqcgkaft 410
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnSLHPPLPANSLSKDPS---------- 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424248 411 HFPSLHNHKKIHTGEKPYTCNECGKAFAHLTSFHNHKKIHTGEKPYGCKQCGKAFSFRSNLQIHETAHKGEKPHECNQCG 490
Cdd:COG5048 182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424248 491 KAF--------AHIVYLQRHERSHGDKPYECNQCGKGFTHFGRLKNHLKS--HTGE--KPYEC--NQCGKVFAYRNNLQK 556
Cdd:COG5048 262 RSSlptassqsSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKR 341

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424248 557 HERTHTGEKPYvcdqcgkafasRCNLQKHEKIHTQEKPYVCNQcgkafasrcNFQVHERIHTGEKSY-SYNQCGKDFVSQ 635
Cdd:COG5048 342 HILLHTSISPA-----------KEKLLNSSSKFSPLLNNEPPQ---------SLQQYKDLKNDKKSEtLSNSCIRNFKRD 401

                       410
                ....*....|....*....
gi 19424248 636 SNLQKHEGKHTGEVTYGCD 654
Cdd:COG5048 402 SNLSLHIITHLSFRPYNCK 420
zf-H2C2_2 pfam13465
Zinc-finger double domain;
553-578 1.51e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.51e-04
                          10        20
                  ....*....|....*....|....*.
gi 19424248   553 NLQKHERTHTGEKPYVCDQCGKAFAS 578
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 7.13e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.21  E-value: 7.13e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 19424248     4 VTYEDVYVSFTQEEWALLNPSQKNLYKDVMMQTCRNLIAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-46 3.56e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.71  E-value: 3.56e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 19424248      4 VTYEDVYVSFTQEEWALLNPSQKNLYKDVMMQTCRNLIAIGYK 46
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 6.31e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 71.81  E-value: 6.31e-16
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 19424248   4 VTYEDVYVSFTQEEWALLNPSQKNLYKDVMMQTCRNLI 41
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
258-654 4.58e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 4.58e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424248 258 KPYKCNQCGKAFASRHNLKMHERIHTGEKPYTCNQ--CGKAFTLYTNLRKHEKIHTGEKPYECS-QCGKAFARRNELQVH 334
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424248 335 ERIHTGEKPYECSQCGKAFASRSNLQTHERTHTGEKPYLCNQCGKAFAWR----RLLQIHERIHTGEKPYacnqcgkaft 410
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnSLHPPLPANSLSKDPS---------- 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424248 411 HFPSLHNHKKIHTGEKPYTCNECGKAFAHLTSFHNHKKIHTGEKPYGCKQCGKAFSFRSNLQIHETAHKGEKPHECNQCG 490
Cdd:COG5048 182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424248 491 KAF--------AHIVYLQRHERSHGDKPYECNQCGKGFTHFGRLKNHLKS--HTGE--KPYEC--NQCGKVFAYRNNLQK 556
Cdd:COG5048 262 RSSlptassqsSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKR 341

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424248 557 HERTHTGEKPYvcdqcgkafasRCNLQKHEKIHTQEKPYVCNQcgkafasrcNFQVHERIHTGEKSY-SYNQCGKDFVSQ 635
Cdd:COG5048 342 HILLHTSISPA-----------KEKLLNSSSKFSPLLNNEPPQ---------SLQQYKDLKNDKKSEtLSNSCIRNFKRD 401

                       410
                ....*....|....*....
gi 19424248 636 SNLQKHEGKHTGEVTYGCD 654
Cdd:COG5048 402 SNLSLHIITHLSFRPYNCK 420
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
258-447 2.03e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 2.03e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424248 258 KPYKCNQCGKAFASRHNLKMHER--IHTGE--KPYTC--NQCGKAFTLYTNLRKHEKIHTGEKPYEC--SQCGKAF---- 325
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFspll 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424248 326 -ARRNELQVHERIHTGEKPYEC--SQCGKAFASRSNLQTHERTHTGEKPYLCNqcgkafawrrllqiherihtgekpyaC 402
Cdd:COG5048 368 nNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCK--------------------------N 421

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 19424248 403 NQCGKAFTHFPSLHNHKKIHTGEKPYTCNECGKAFAHLTSFHNHK 447
Cdd:COG5048 422 PPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
251-557 6.03e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 6.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424248 251 HRTHTGEKPYKCNQCGKAFASRHNLKMHERIHTGEKPYTCNQCGKAFT------LYTNLRKHEKIHTGEKPYECSQCGKA 324
Cdd:COG5048 190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPksllsqSPSSLSSSDSSSSASESPRSSLPTAS 269

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424248 325 FARRNELQVHERIHTG-EKPYECSQCGKAFASRSNLQTHERT--HTGE--KPYLC--NQCGKAFAWRRLLQIHERIHTGE 397
Cdd:COG5048 270 SQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSI 349

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424248 398 KPYACNqcgkaFTHFPSLHNHKKIHtgekpytcnecgkafAHLTSFHNHKKIHTGEKPYGCKQ-CGKAFSFRSNLQIHET 476
Cdd:COG5048 350 SPAKEK-----LLNSSSKFSPLLNN---------------EPPQSLQQYKDLKNDKKSETLSNsCIRNFKRDSNLSLHII 409

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424248 477 AHKGEKPHECNqcgkafahivylqrhershgdkpyeCNQCGKGFTHFGRLKNHLKSHTGEKPYECNQCGKvFAYRNNLQK 556
Cdd:COG5048 410 THLSFRPYNCK-------------------------NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSN 463


                .
gi 19424248 557 H 557
Cdd:COG5048 464 H 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
553-578 1.51e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.51e-04
                          10        20
                  ....*....|....*....|....*.
gi 19424248   553 NLQKHERTHTGEKPYVCDQCGKAFAS 578
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
302-327 1.82e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.82e-04
                          10        20
                  ....*....|....*....|....*.
gi 19424248   302 NLRKHEKIHTGEKPYECSQCGKAFAR 327
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
274-298 3.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.95e-04
                          10        20
                  ....*....|....*....|....*
gi 19424248   274 NLKMHERIHTGEKPYTCNQCGKAFT 298
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
330-355 4.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.91e-04
                          10        20
                  ....*....|....*....|....*.
gi 19424248   330 ELQVHERIHTGEKPYECSQCGKAFAS 355
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 256-334 6.97e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 6.97e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424248 256 GEKPYKCN--QCGKAFASRHNLKMHeRIHtgekpytcNQCGKAFTLYTNLRKHEKIHTGEKPYECSQCGKAFARRNELQV 333
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                .
gi 19424248 334 H 334
Cdd:COG5189 417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
581-606 7.94e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.94e-04
                          10        20
                  ....*....|....*....|....*.
gi 19424248   581 NLQKHEKIHTQEKPYVCNQCGKAFAS 606
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
358-382 8.25e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.25e-04
                          10        20
                  ....*....|....*....|....*
gi 19424248   358 NLQTHERTHTGEKPYLCNQCGKAFA 382
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
387-411 1.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.69e-03
                          10        20
                  ....*....|....*....|....*
gi 19424248   387 LQIHERIHTGEKPYACNQCGKAFTH 411
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
525-550 1.90e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.90e-03
                          10        20
                  ....*....|....*....|....*.
gi 19424248   525 RLKNHLKSHTGEKPYECNQCGKVFAY 550
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2HE pfam16278
C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in ...
 508-533 2.78e-03

C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in fungi, plants and metazoa. It is often found at the C-terminus of HIT-domain-containing proteins, pfam01230. In fungi the fourth ligand is a Glu, in plants it is Cys and in metazoans it is usually a His. The fourth ligand is often mutated in neurogenerative disease-states.


Pssm-ID: 465082  Cd Length: 60  Bit Score: 36.50  E-value: 2.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 19424248   508 DKPYECNQCGKGFTHFGRLKNHLKSH 533
Cdd:pfam16278  32 KTPLKCHRCGNFGNNFPKLKAHLEEH 57
zf-H2C2_2 pfam13465
Zinc-finger double domain;
418-439 5.94e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.94e-03
                          10        20
                  ....*....|....*....|..
gi 19424248   418 HKKIHTGEKPYTCNECGKAFAH 439
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH