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Conserved domains on  [gi|19112423|ref|NP_595631|]
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cytochrome c oxidase assembly protein Shy1 [Schizosaccharomyces pombe]

Protein Classification

SURF1 family protein( domain architecture ID 10160031)

surfeit locus protein 1 (SURF1) family protein similar to Homo sapiens surfeit locus protein 1, a component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly

Gene Ontology:  GO:0033617

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SURF1 cd06662
SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the ...
50-261 2.86e-65

SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring complex of the respiratory chain, is an assemblage of nuclear and mitochondrially-encoded subunits. Its assembly is mediated by nuclear encoded assembly factors, one of which is Surf1/Shy1. Mutations in human Surf1 are a major cause of Leigh syndrome, a severe neurodegenerative disorder.


:

Pssm-ID: 119401  Cd Length: 202  Bit Score: 202.96  E-value: 2.86e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112423  50 TFALGTWQVKRREWKMGIINTLTERLQQPAILLPkTVTEQDTKKLEWTRVLLRGVFCHDQEMLVGPRTKEGQPGYHVVTP 129
Cdd:cd06662   1 LVGLGFWQLQRAEWKEALIARIEARLAAPPVPLP-ELLAPPLEDLEYRRVTVTGTFLPEKEVLLDNRTRDGRPGYEVLTP 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112423 130 FILDDGRRILVNRGWIARSFAEQSSRDPsSLPKGPVVIEGLLRQHTDKPRFMMKNEPEKNSFYFLNVREFAQLKGTLPIL 209
Cdd:cd06662  80 FRLDDGRTVLVNRGWVPADADRPALPAV-APPTGEVTVTGRLRPPEPRGLFLPPNDPAANPWQNRDLEAMAQALGLPLVP 158
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 19112423 210 ITELQPSLTPlqeadhvkRGLPLGHPLKVEIFNSHTEYIITWYSLSVVSAIM 261
Cdd:cd06662 159 LVLQLASGAP--------PGLPRPWPPPVMIPNKHLGYAVQWFALAAAALVL 202
 
Name Accession Description Interval E-value
SURF1 cd06662
SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the ...
50-261 2.86e-65

SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring complex of the respiratory chain, is an assemblage of nuclear and mitochondrially-encoded subunits. Its assembly is mediated by nuclear encoded assembly factors, one of which is Surf1/Shy1. Mutations in human Surf1 are a major cause of Leigh syndrome, a severe neurodegenerative disorder.


Pssm-ID: 119401  Cd Length: 202  Bit Score: 202.96  E-value: 2.86e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112423  50 TFALGTWQVKRREWKMGIINTLTERLQQPAILLPkTVTEQDTKKLEWTRVLLRGVFCHDQEMLVGPRTKEGQPGYHVVTP 129
Cdd:cd06662   1 LVGLGFWQLQRAEWKEALIARIEARLAAPPVPLP-ELLAPPLEDLEYRRVTVTGTFLPEKEVLLDNRTRDGRPGYEVLTP 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112423 130 FILDDGRRILVNRGWIARSFAEQSSRDPsSLPKGPVVIEGLLRQHTDKPRFMMKNEPEKNSFYFLNVREFAQLKGTLPIL 209
Cdd:cd06662  80 FRLDDGRTVLVNRGWVPADADRPALPAV-APPTGEVTVTGRLRPPEPRGLFLPPNDPAANPWQNRDLEAMAQALGLPLVP 158
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 19112423 210 ITELQPSLTPlqeadhvkRGLPLGHPLKVEIFNSHTEYIITWYSLSVVSAIM 261
Cdd:cd06662 159 LVLQLASGAP--------PGLPRPWPPPVMIPNKHLGYAVQWFALAAAALVL 202
Shy1 COG3346
Cytochrome oxidase assembly protein ShyY1 [Posttranslational modification, protein turnover, ...
38-268 2.57e-53

Cytochrome oxidase assembly protein ShyY1 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442575  Cd Length: 245  Bit Score: 173.96  E-value: 2.57e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112423  38 FLVGLLSAVpiVTFALGTWQVKRREWKMGIINTLTERLQQPAILLPKTVTEQDT--KKLEWTRVLLRGVFCHDQEMLVGP 115
Cdd:COG3346  13 LLLALVLAA--VLVALGFWQLQRAEEKEALIARIEARLAAPPVPLPELLAWPAAfpADDEYRRVTVTGRYLPDHQVLLDN 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112423 116 RTKEGQPGYHVVTPFILDDGRRILVNRGWIARSFAEQSSRDPSSLPKGPVVIEGLLRQHTDKPRFMMKNEPEKNSFYFLN 195
Cdd:COG3346  91 RTLDGRPGYEVLTPLRLDDGRAVLVNRGWVPAGADRAALPRVPAPPAGEVTVTGRLRPPEPRGSFLPGNDPPEGQVQSID 170
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19112423 196 VREFAQLKGT--LPILITELQPSLTPLQEADhvkrgLPLGHPlkveifNSHTEYIITWYSLSVVSAIMlYVYFKR 268
Cdd:COG3346 171 LAALAAALGLplAPYVLDLDAESPGGLRPWP-----PPVLDP------GRHLGYALQWFALALAALGL-YVYLAR 233
SURF1 pfam02104
SURF1 family;
45-256 1.54e-48

SURF1 family;


Pssm-ID: 460447  Cd Length: 195  Bit Score: 159.87  E-value: 1.54e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112423    45 AVPIVTFALGTWQVKRREWKMGIINTLTERLQQPAILLPKTVTEQDTKKLEWTRVLLRGVFcHDQEMLVGPRTKEGQpGY 124
Cdd:pfam02104   2 LPAAVFFALGTWQLQRLEWKEALIAALEARVAAPPLPLPLPPDDAVPADLEYRRVTVTGRF-DDKEVLVGNRVGRPR-GY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112423   125 HVVTPFIL-DDGRRILVNRGWIARSFAEQssrdPSSLPKGPVVIEGLLRQhtdkprfmMKNEPEKNS-FYFLNVREFAQL 202
Cdd:pfam02104  80 HVLTPLRLtDDGRTVLVNRGWVPAGADKL----PARPPAGPVRVTGRLRA--------PEGGGAPGGqWYSIDVAALAAA 147
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 19112423   203 kgtLPILITELQPSLTplqEADHVKRGLPLGHPLKVEIFNSHTEYIITWYSLSV 256
Cdd:pfam02104 148 ---LGLLLPRPAPVLI---DADADPPDGGIGGQPVVNLPNNHLGYALQWFGLAA 195
 
Name Accession Description Interval E-value
SURF1 cd06662
SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the ...
50-261 2.86e-65

SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring complex of the respiratory chain, is an assemblage of nuclear and mitochondrially-encoded subunits. Its assembly is mediated by nuclear encoded assembly factors, one of which is Surf1/Shy1. Mutations in human Surf1 are a major cause of Leigh syndrome, a severe neurodegenerative disorder.


Pssm-ID: 119401  Cd Length: 202  Bit Score: 202.96  E-value: 2.86e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112423  50 TFALGTWQVKRREWKMGIINTLTERLQQPAILLPkTVTEQDTKKLEWTRVLLRGVFCHDQEMLVGPRTKEGQPGYHVVTP 129
Cdd:cd06662   1 LVGLGFWQLQRAEWKEALIARIEARLAAPPVPLP-ELLAPPLEDLEYRRVTVTGTFLPEKEVLLDNRTRDGRPGYEVLTP 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112423 130 FILDDGRRILVNRGWIARSFAEQSSRDPsSLPKGPVVIEGLLRQHTDKPRFMMKNEPEKNSFYFLNVREFAQLKGTLPIL 209
Cdd:cd06662  80 FRLDDGRTVLVNRGWVPADADRPALPAV-APPTGEVTVTGRLRPPEPRGLFLPPNDPAANPWQNRDLEAMAQALGLPLVP 158
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 19112423 210 ITELQPSLTPlqeadhvkRGLPLGHPLKVEIFNSHTEYIITWYSLSVVSAIM 261
Cdd:cd06662 159 LVLQLASGAP--------PGLPRPWPPPVMIPNKHLGYAVQWFALAAAALVL 202
Shy1 COG3346
Cytochrome oxidase assembly protein ShyY1 [Posttranslational modification, protein turnover, ...
38-268 2.57e-53

Cytochrome oxidase assembly protein ShyY1 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442575  Cd Length: 245  Bit Score: 173.96  E-value: 2.57e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112423  38 FLVGLLSAVpiVTFALGTWQVKRREWKMGIINTLTERLQQPAILLPKTVTEQDT--KKLEWTRVLLRGVFCHDQEMLVGP 115
Cdd:COG3346  13 LLLALVLAA--VLVALGFWQLQRAEEKEALIARIEARLAAPPVPLPELLAWPAAfpADDEYRRVTVTGRYLPDHQVLLDN 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112423 116 RTKEGQPGYHVVTPFILDDGRRILVNRGWIARSFAEQSSRDPSSLPKGPVVIEGLLRQHTDKPRFMMKNEPEKNSFYFLN 195
Cdd:COG3346  91 RTLDGRPGYEVLTPLRLDDGRAVLVNRGWVPAGADRAALPRVPAPPAGEVTVTGRLRPPEPRGSFLPGNDPPEGQVQSID 170
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19112423 196 VREFAQLKGT--LPILITELQPSLTPLQEADhvkrgLPLGHPlkveifNSHTEYIITWYSLSVVSAIMlYVYFKR 268
Cdd:COG3346 171 LAALAAALGLplAPYVLDLDAESPGGLRPWP-----PPVLDP------GRHLGYALQWFALALAALGL-YVYLAR 233
SURF1 pfam02104
SURF1 family;
45-256 1.54e-48

SURF1 family;


Pssm-ID: 460447  Cd Length: 195  Bit Score: 159.87  E-value: 1.54e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112423    45 AVPIVTFALGTWQVKRREWKMGIINTLTERLQQPAILLPKTVTEQDTKKLEWTRVLLRGVFcHDQEMLVGPRTKEGQpGY 124
Cdd:pfam02104   2 LPAAVFFALGTWQLQRLEWKEALIAALEARVAAPPLPLPLPPDDAVPADLEYRRVTVTGRF-DDKEVLVGNRVGRPR-GY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112423   125 HVVTPFIL-DDGRRILVNRGWIARSFAEQssrdPSSLPKGPVVIEGLLRQhtdkprfmMKNEPEKNS-FYFLNVREFAQL 202
Cdd:pfam02104  80 HVLTPLRLtDDGRTVLVNRGWVPAGADKL----PARPPAGPVRVTGRLRA--------PEGGGAPGGqWYSIDVAALAAA 147
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 19112423   203 kgtLPILITELQPSLTplqEADHVKRGLPLGHPLKVEIFNSHTEYIITWYSLSV 256
Cdd:pfam02104 148 ---LGLLLPRPAPVLI---DADADPPDGGIGGQPVVNLPNNHLGYALQWFGLAA 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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