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Conserved domains on  [gi|19112280|ref|NP_595488|]
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C2H2-type zinc finger domain-containing protein [Schizosaccharomyces pombe]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SERRATE_Ars2_N super family cl13496
SERRATE/Ars2, N-terminal domain; This domain can be found in the N terminus of the SERRATE (SE) ...
 109-179 6.19e-07

SERRATE/Ars2, N-terminal domain; This domain can be found in the N terminus of the SERRATE (SE) from plants and its homolog, Ars2, from animals. They play a role in nuclear RNA metabolism. They interact with the nuclear cap-binding complex (CBC) and mediates interactions with diverse RNA processing and transport machineries in a transcript-dependent manner. Interestingly, the plant SERRATE does not have the RNA recognition motif (RRM) domain found in metazoans and S. pombe. This domain has two completely conserved Y residues that may be functionally important.


The actual alignment was detected with superfamily member pfam12066:

Pssm-ID: 463453 [Multi-domain]  Cd Length: 110  Bit Score: 48.39  E-value: 6.19e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19112280   109 YNNYKQDLYARTARSFVESHCDEAWFEDSYWVDESQGRVLEVseneKSYRRALYDKFMDRLDAGYYDDFQL 179
Cdd:pfam12066  20 YDEYKLEFQRKQANEFFVAHKDEEWFKEKYHPEERDKRREEL----REFRRKRLEVFEEDLESGVFDEVSL 86
ARS2 super family cl20283
Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a ...
 473-560 1.58e-06

Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a co-mutagen by inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance.


The actual alignment was detected with superfamily member pfam04959:

Pssm-ID: 461498  Cd Length: 195  Bit Score: 49.11  E-value: 1.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112280   473 KYRChvGTCAKLFLGPEFVRKHINKKHKDWLDHIKKVAICLYGYVLDPCRAMDPKvvstsyvsLQILNKPYVGFRNINAN 552
Cdd:pfam04959  67 KWLC--PLSGKKFKGPEFVRKHILNKHGDKVEEVRSEVEFFNNYLADAKRPATPE--------LKPKPPPRPANRRERPG 136


                  ....*...
gi 19112280   553 YTFPTTSY 560
Cdd:pfam04959 137 RAFPSQRP 144
 
Name Accession Description Interval E-value
SERRATE_Ars2_N pfam12066
SERRATE/Ars2, N-terminal domain; This domain can be found in the N terminus of the SERRATE (SE) ...
 109-179 6.19e-07

SERRATE/Ars2, N-terminal domain; This domain can be found in the N terminus of the SERRATE (SE) from plants and its homolog, Ars2, from animals. They play a role in nuclear RNA metabolism. They interact with the nuclear cap-binding complex (CBC) and mediates interactions with diverse RNA processing and transport machineries in a transcript-dependent manner. Interestingly, the plant SERRATE does not have the RNA recognition motif (RRM) domain found in metazoans and S. pombe. This domain has two completely conserved Y residues that may be functionally important.


Pssm-ID: 463453 [Multi-domain]  Cd Length: 110  Bit Score: 48.39  E-value: 6.19e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19112280   109 YNNYKQDLYARTARSFVESHCDEAWFEDSYWVDESQGRVLEVseneKSYRRALYDKFMDRLDAGYYDDFQL 179
Cdd:pfam12066  20 YDEYKLEFQRKQANEFFVAHKDEEWFKEKYHPEERDKRREEL----REFRRKRLEVFEEDLESGVFDEVSL 86
ARS2 pfam04959
Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a ...
 473-560 1.58e-06

Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a co-mutagen by inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance.


Pssm-ID: 461498  Cd Length: 195  Bit Score: 49.11  E-value: 1.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112280   473 KYRChvGTCAKLFLGPEFVRKHINKKHKDWLDHIKKVAICLYGYVLDPCRAMDPKvvstsyvsLQILNKPYVGFRNINAN 552
Cdd:pfam04959  67 KWLC--PLSGKKFKGPEFVRKHILNKHGDKVEEVRSEVEFFNNYLADAKRPATPE--------LKPKPPPRPANRRERPG 136


                  ....*...
gi 19112280   553 YTFPTTSY 560
Cdd:pfam04959 137 RAFPSQRP 144
 
Name Accession Description Interval E-value
SERRATE_Ars2_N pfam12066
SERRATE/Ars2, N-terminal domain; This domain can be found in the N terminus of the SERRATE (SE) ...
 109-179 6.19e-07

SERRATE/Ars2, N-terminal domain; This domain can be found in the N terminus of the SERRATE (SE) from plants and its homolog, Ars2, from animals. They play a role in nuclear RNA metabolism. They interact with the nuclear cap-binding complex (CBC) and mediates interactions with diverse RNA processing and transport machineries in a transcript-dependent manner. Interestingly, the plant SERRATE does not have the RNA recognition motif (RRM) domain found in metazoans and S. pombe. This domain has two completely conserved Y residues that may be functionally important.


Pssm-ID: 463453 [Multi-domain]  Cd Length: 110  Bit Score: 48.39  E-value: 6.19e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19112280   109 YNNYKQDLYARTARSFVESHCDEAWFEDSYWVDESQGRVLEVseneKSYRRALYDKFMDRLDAGYYDDFQL 179
Cdd:pfam12066  20 YDEYKLEFQRKQANEFFVAHKDEEWFKEKYHPEERDKRREEL----REFRRKRLEVFEEDLESGVFDEVSL 86
ARS2 pfam04959
Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a ...
 473-560 1.58e-06

Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a co-mutagen by inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance.


Pssm-ID: 461498  Cd Length: 195  Bit Score: 49.11  E-value: 1.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112280   473 KYRChvGTCAKLFLGPEFVRKHINKKHKDWLDHIKKVAICLYGYVLDPCRAMDPKvvstsyvsLQILNKPYVGFRNINAN 552
Cdd:pfam04959  67 KWLC--PLSGKKFKGPEFVRKHILNKHGDKVEEVRSEVEFFNNYLADAKRPATPE--------LKPKPPPRPANRRERPG 136


                  ....*...
gi 19112280   553 YTFPTTSY 560
Cdd:pfam04959 137 RAFPSQRP 144
LPD16 pfam18830
Large polyvalent protein-associated domain 16; This is an alpha and beta fold domain that is ...
 138-183 1.19e-04

Large polyvalent protein-associated domain 16; This is an alpha and beta fold domain that is mainly found in polyvalent proteins of conjugative elements.


Pssm-ID: 436769  Cd Length: 82  Bit Score: 41.06  E-value: 1.19e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 19112280   138 YWVDESQgrVLEVSENEKSYRRALYDKFMDRLDAGYYDDFQLPTAE 183
Cdd:pfam18830   8 YLLNDWQ--YLHIQECEEGYDYTLYDKDYRELDGGQLDNPDLSLSE 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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