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Conserved domains on  [gi|19114622|ref|NP_593710|]
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rixosome complex WD repeat subunit Crb3 [Schizosaccharomyces pombe]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
85-342 1.92e-26

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.39  E-value: 1.92e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622  85 SPCGSWLAAGTEKGNLYIWSLKSGALIYFFRAHYQPLTILKFSNDGMVLFTASNDGDVFAWLISTLvdqnstfetsnssv 164
Cdd:COG2319 129 SPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-------------- 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622 165 KAISHFSGHKRSIVSMEIGPGpivSGRLYTASEDNTIRIWDVSTGNLLTTIALPSTP-SCMTVDPSERVVYVGNEKGIIW 243
Cdd:COG2319 195 KLLRTLTGHTGAVRSVAFSPD---GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSvRSVAFSPDGRLLASGSADGTVR 271

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622 244 I-PLYTGS--STFSNNvkeKKRVTSV----DNTTIpnAIGGMGRVV---DYNDSRESSIISC-QSPITTLTVSFDASLLI 312
Cdd:COG2319 272 LwDLATGEllRTLTGH---SGGVNSVafspDGKLL--ASGSDDGTVrlwDLATGKLLRTLTGhTGAVRSVAFSPDGKTLA 346

                       250       260       270
                ....*....|....*....|....*....|
gi 19114622 313 SGDKDGNVLVWDSVSRQVLRRLVQYYSPVS 342
Cdd:COG2319 347 SGSDDGTVRLWDLATGELLRTLTGHTGAVT 376
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
85-342 1.92e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.39  E-value: 1.92e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622  85 SPCGSWLAAGTEKGNLYIWSLKSGALIYFFRAHYQPLTILKFSNDGMVLFTASNDGDVFAWLISTLvdqnstfetsnssv 164
Cdd:COG2319 129 SPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-------------- 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622 165 KAISHFSGHKRSIVSMEIGPGpivSGRLYTASEDNTIRIWDVSTGNLLTTIALPSTP-SCMTVDPSERVVYVGNEKGIIW 243
Cdd:COG2319 195 KLLRTLTGHTGAVRSVAFSPD---GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSvRSVAFSPDGRLLASGSADGTVR 271

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622 244 I-PLYTGS--STFSNNvkeKKRVTSV----DNTTIpnAIGGMGRVV---DYNDSRESSIISC-QSPITTLTVSFDASLLI 312
Cdd:COG2319 272 LwDLATGEllRTLTGH---SGGVNSVafspDGKLL--ASGSDDGTVrlwDLATGKLLRTLTGhTGAVRSVAFSPDGKTLA 346

                       250       260       270
                ....*....|....*....|....*....|
gi 19114622 313 SGDKDGNVLVWDSVSRQVLRRLVQYYSPVS 342
Cdd:COG2319 347 SGSDDGTVRLWDLATGELLRTLTGHTGAVT 376
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 81-355 1.78e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.11  E-value: 1.78e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622  81 CVQSSPCGSWLAAGTEKGNLYIWSLKSGALIYFFRAHYQPLTILKFSNDGMVLFTASNDGDVFAWLISTLvdqnstfets 160
Cdd:cd00200  14 CVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG---------- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622 161 nssvKAISHFSGHKRSIVSMEIGP-GPIVSGrlytASEDNTIRIWDVSTGNLLTTIALPSTP-SCMTVDPSERVVYVG-- 236
Cdd:cd00200  84 ----ECVRTLTGHTSYVSSVAFSPdGRILSS----SSRDKTIKVWDVETGKCLTTLRGHTDWvNSVAFSPDGTFVASSsq 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622 237 NEKGIIW-------IPLYTG------SSTFSNNvkEKKRVTSVDNTTIpnaiggmgRVVDYNDSRES-SIISCQSPITTL 302
Cdd:cd00200 156 DGTIKLWdlrtgkcVATLTGhtgevnSVAFSPD--GEKLLSSSSDGTI--------KLWDLSTGKCLgTLRGHENGVNSV 225

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 19114622 303 TVSFDASLLISGDKDGNVLVWDSVSRQVLRRLVQYYSPVSFLQCKVDKISFYS 355
Cdd:cd00200 226 AFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLAS 278
PTZ00421 PTZ00421
coronin; Provisional
 129-215 3.37e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.04  E-value: 3.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622  129 DGMVLFTASNDGDVFAWLISTlvdqnsTFETSNSSvKAISHFSGH--KRSIVSMEigpgPIVSGRLYTASEDNTIRIWDV 206
Cdd:PTZ00421  87 DPQKLFTASEDGTIMGWGIPE------EGLTQNIS-DPIVHLQGHtkKVGIVSFH----PSAMNVLASAGADMVVNVWDV 155


                 ....*....
gi 19114622  207 STGNLLTTI 215
Cdd:PTZ00421 156 ERGKAVEVI 164
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 107-145 7.53e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 7.53e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 19114622    107 SGALIYFFRAHYQPLTILKFSNDGMVLFTASNDGDVFAW 145
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
Nucleoporin_N pfam08801
Nup133 N terminal like; Nup133 is a nucleoporin that is crucial for nuclear pore complex (NPC) ...
 98-210 1.19e-03

Nup133 N terminal like; Nup133 is a nucleoporin that is crucial for nuclear pore complex (NPC) biogenesis. The N terminal forms a seven-bladed beta propeller structure. This family now contains other sized nucleoporins, including Nup155, Nup8, Nuo132, Nup15 and Nup170.


Pssm-ID: 400932  Cd Length: 426  Bit Score: 41.22  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622    98 GNLYIWSLKSGALIYFFRA-HYQPLTILKFSNDGMVLFTASN---DGDVFA-------WLIsTLVDQNSTF--------- 157
Cdd:pfam08801 102 GDIVYWESISSAGALLSLNeLQGLETDLSVLSDGEYVTDLVNsepAGRIFLagstgrlYEL-TYRDSSGKPslkcrkirs 180

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 19114622   158 -ETSNSSVKAISHFSGHK---RSIVSMEIGPGpIVSGRLYTASEDNTIRIWDVSTGN 210
Cdd:pfam08801 181 pSGGFSSLSIIPSVFGGGserEEIVSLRVDPS-RGERLLYTLTSKGVIQVWDLSSSG 236
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 191-238 4.03e-03

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 39.25  E-value: 4.03e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 19114622   191 RLYT-ASEDNTIRIWDVSTGNLLTTiaLPS--TPSCMTVDPSERVVYVGNE 238
Cdd:TIGR03866  54 LLYVcASDSDTIQVIDPATGEVLHT--LPSgpDPEQFALHPNGKILYIANE 102
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
85-342 1.92e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.39  E-value: 1.92e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622  85 SPCGSWLAAGTEKGNLYIWSLKSGALIYFFRAHYQPLTILKFSNDGMVLFTASNDGDVFAWLISTLvdqnstfetsnssv 164
Cdd:COG2319 129 SPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-------------- 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622 165 KAISHFSGHKRSIVSMEIGPGpivSGRLYTASEDNTIRIWDVSTGNLLTTIALPSTP-SCMTVDPSERVVYVGNEKGIIW 243
Cdd:COG2319 195 KLLRTLTGHTGAVRSVAFSPD---GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSvRSVAFSPDGRLLASGSADGTVR 271

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622 244 I-PLYTGS--STFSNNvkeKKRVTSV----DNTTIpnAIGGMGRVV---DYNDSRESSIISC-QSPITTLTVSFDASLLI 312
Cdd:COG2319 272 LwDLATGEllRTLTGH---SGGVNSVafspDGKLL--ASGSDDGTVrlwDLATGKLLRTLTGhTGAVRSVAFSPDGKTLA 346

                       250       260       270
                ....*....|....*....|....*....|
gi 19114622 313 SGDKDGNVLVWDSVSRQVLRRLVQYYSPVS 342
Cdd:COG2319 347 SGSDDGTVRLWDLATGELLRTLTGHTGAVT 376
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 81-355 1.78e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.11  E-value: 1.78e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622  81 CVQSSPCGSWLAAGTEKGNLYIWSLKSGALIYFFRAHYQPLTILKFSNDGMVLFTASNDGDVFAWLISTLvdqnstfets 160
Cdd:cd00200  14 CVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG---------- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622 161 nssvKAISHFSGHKRSIVSMEIGP-GPIVSGrlytASEDNTIRIWDVSTGNLLTTIALPSTP-SCMTVDPSERVVYVG-- 236
Cdd:cd00200  84 ----ECVRTLTGHTSYVSSVAFSPdGRILSS----SSRDKTIKVWDVETGKCLTTLRGHTDWvNSVAFSPDGTFVASSsq 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622 237 NEKGIIW-------IPLYTG------SSTFSNNvkEKKRVTSVDNTTIpnaiggmgRVVDYNDSRES-SIISCQSPITTL 302
Cdd:cd00200 156 DGTIKLWdlrtgkcVATLTGhtgevnSVAFSPD--GEKLLSSSSDGTI--------KLWDLSTGKCLgTLRGHENGVNSV 225

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 19114622 303 TVSFDASLLISGDKDGNVLVWDSVSRQVLRRLVQYYSPVSFLQCKVDKISFYS 355
Cdd:cd00200 226 AFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLAS 278
WD40 COG2319
WD40 repeat [General function prediction only];
82-334 2.19e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.30  E-value: 2.19e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622  82 VQSSPCGSWLAAGTEKGNLYIWSLKSGALIYFFRAHYQPLTILKFSNDGMVLFTASNDGDVFAWLISTLvdqnstfetsn 161
Cdd:COG2319  84 VAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG----------- 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622 162 ssvKAISHFSGHKRSIVSMEIGPgpivSGR-LYTASEDNTIRIWDVSTGNLLTTIALPSTP-SCMTVDP-SERVVYVGNE 238
Cdd:COG2319 153 ---KLLRTLTGHSGAVTSVAFSP----DGKlLASGSDDGTVRLWDLATGKLLRTLTGHTGAvRSVAFSPdGKLLASGSAD 225

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622 239 KGIIWIPLYTGSSTFSNNVKEkKRVTSV----DNTTIpnAIGGMGRVV---DYNDSRESSIIS-CQSPITTLTVSFDASL 310
Cdd:COG2319 226 GTVRLWDLATGKLLRTLTGHS-GSVRSVafspDGRLL--ASGSADGTVrlwDLATGELLRTLTgHSGGVNSVAFSPDGKL 302

                       250       260
                ....*....|....*....|....
gi 19114622 311 LISGDKDGNVLVWDSVSRQVLRRL 334
Cdd:COG2319 303 LASGSDDGTVRLWDLATGKLLRTL 326
WD40 COG2319
WD40 repeat [General function prediction only];
88-324 1.43e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.91  E-value: 1.43e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622  88 GSWLAAGTEKGNLYIWSLKSGALIYFFRAHYQPLTILKFSNDGMVLFTASNDGDVFAWLISTlvdqnstfetsnssVKAI 167
Cdd:COG2319 174 GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT--------------GKLL 239

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622 168 SHFSGHKRSIVSMEIGPgpivSGR-LYTASEDNTIRIWDVSTGNLLTTIALPSTP-SCMTVDPSERVVYVGNEKGIIWI- 244
Cdd:COG2319 240 RTLTGHSGSVRSVAFSP----DGRlLASGSADGTVRLWDLATGELLRTLTGHSGGvNSVAFSPDGKLLASGSDDGTVRLw 315

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622 245 PLYTGS--STFSNNVKekkRVTSV----DNTTIpnAIGGMGRVVDYNDSRESSIISC----QSPITTLTVSFDASLLISG 314
Cdd:COG2319 316 DLATGKllRTLTGHTG---AVRSVafspDGKTL--ASGSDDGTVRLWDLATGELLRTltghTGAVTSVAFSPDGRTLASG 390

                       250
                ....*....|
gi 19114622 315 DKDGNVLVWD 324
Cdd:COG2319 391 SADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 81-244 1.12e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.15  E-value: 1.12e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622  81 CVQSSPCGSWLAAGTEKGNLYIWSLKSGALIYFFRAHYQPLTILKFSNDGMVLFTASNDGDVFAWLISTLvdqnstfets 160
Cdd:cd00200 140 SVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG---------- 209

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622 161 nssvKAISHFSGHKRSIVSMEIGPgpivSGRLYT-ASEDNTIRIWDVSTGNLLTTIALPSTP-SCMTVDPSERVVYVGNE 238
Cdd:cd00200 210 ----KCLGTLRGHENGVNSVAFSP----DGYLLAsGSEDGTIRVWDLRTGECVQTLSGHTNSvTSLAWSPDGKRLASGSA 281


                ....*.
gi 19114622 239 KGIIWI 244
Cdd:cd00200 282 DGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
85-208 2.33e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.73  E-value: 2.33e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622  85 SPCGSWLAAGTEKGNLYIWSLKSGALIYFFRAHYQPLTILKFSNDGMVLFTASNDGDVFAWLISTLvdqnstfetsnssv 164
Cdd:COG2319 297 SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG-------------- 362

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 19114622 165 KAISHFSGHKRSIVSMEIGPGpivSGRLYTASEDNTIRIWDVST 208
Cdd:COG2319 363 ELLRTLTGHTGAVTSVAFSPD---GRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
81-145 8.58e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.23  E-value: 8.58e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19114622  81 CVQSSPCGSWLAAGTEKGNLYIWSLKSGALIYFFRAHYQPLTILKFSNDGMVLFTASNDGDVFAW 145
Cdd:COG2319 335 SVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 77-140 8.40e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.49  E-value: 8.40e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19114622  77 EILICVQSSPCGSWLAAGTEKGNLYIWSLKSGALIYFFRAHYQPLTILKFSNDGMVLFTASNDG 140
Cdd:cd00200 220 NGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADG 283
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
159-238 5.27e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 50.46  E-value: 5.27e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622 159 TSNSSVKAISHFSGHKRSIVSMEIGPGPIV----SGRLY-TASEDNTIRIWDVSTGNLLTTIALPSTPSCMTVDPSERVV 233
Cdd:COG3391  87 SGSGRVSVIDLATGKVVATIPVGGGPRGLAvdpdGGRLYvADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRL 166


                ....*
gi 19114622 234 YVGNE 238
Cdd:COG3391 167 YVANS 171
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
183-334 1.12e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 46.61  E-value: 1.12e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622 183 GPGPIVSGRLY-TASEDNTIRIWDVSTGNLLTTIALPSTPSCMTVDPSERVVYVGNEkgiiwiplytgsstfSNNvkekk 261
Cdd:COG3391  73 ADAGADGRRLYvANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADS---------------GNG----- 132

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19114622 262 RVTSVDNTTipnaiggmGRVVDyndsresSIISCQSPiTTLTVSFDASLLISGDKDGN-----VLVWDSVSRQVLRRL 334
Cdd:COG3391 133 RVSVIDTAT--------GKVVA-------TIPVGAGP-HGIAVDPDGKRLYVANSGSNtvsviVSVIDTATGKVVATI 194
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
92-237 2.11e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.84  E-value: 2.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622  92 AAGTEKGNLYIWSLKSGALIYFFRAHYQPLTILkFSNDGMVLFTASNDGDvfawlistlvdqnstfetsnssvkAISHFS 171
Cdd:COG3391  84 VANSGSGRVSVIDLATGKVVATIPVGGGPRGLA-VDPDGGRLYVADSGNG------------------------RVSVID 138

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19114622 172 GHKRSIV-SMEIGPGP---IVS---GRLYTASEDNT-----IRIWDVSTGNLLTTIALPSTPSCMTVDPSERVVYVGN 237
Cdd:COG3391 139 TATGKVVaTIPVGAGPhgiAVDpdgKRLYVANSGSNtvsviVSVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYVAN 216
PTZ00421 PTZ00421
coronin; Provisional
 129-215 3.37e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.04  E-value: 3.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622  129 DGMVLFTASNDGDVFAWLISTlvdqnsTFETSNSSvKAISHFSGH--KRSIVSMEigpgPIVSGRLYTASEDNTIRIWDV 206
Cdd:PTZ00421  87 DPQKLFTASEDGTIMGWGIPE------EGLTQNIS-DPIVHLQGHtkKVGIVSFH----PSAMNVLASAGADMVVNVWDV 155


                 ....*....
gi 19114622  207 STGNLLTTI 215
Cdd:PTZ00421 156 ERGKAVEVI 164
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
193-240 2.54e-04

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 42.97  E-value: 2.54e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 19114622 193 YTASEDNTIRIWDVSTGN----LLTTIALPSTPSCMTVDPSERVVYVGNEKG 240
Cdd:COG2706  15 YTSGESEGIYVFRLDTATgeltLLGLVAALGNPSFLALSPDGRFLYAVNEVD 66
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 107-145 7.53e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 7.53e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 19114622    107 SGALIYFFRAHYQPLTILKFSNDGMVLFTASNDGDVFAW 145
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
Nucleoporin_N pfam08801
Nup133 N terminal like; Nup133 is a nucleoporin that is crucial for nuclear pore complex (NPC) ...
 98-210 1.19e-03

Nup133 N terminal like; Nup133 is a nucleoporin that is crucial for nuclear pore complex (NPC) biogenesis. The N terminal forms a seven-bladed beta propeller structure. This family now contains other sized nucleoporins, including Nup155, Nup8, Nuo132, Nup15 and Nup170.


Pssm-ID: 400932  Cd Length: 426  Bit Score: 41.22  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114622    98 GNLYIWSLKSGALIYFFRA-HYQPLTILKFSNDGMVLFTASN---DGDVFA-------WLIsTLVDQNSTF--------- 157
Cdd:pfam08801 102 GDIVYWESISSAGALLSLNeLQGLETDLSVLSDGEYVTDLVNsepAGRIFLagstgrlYEL-TYRDSSGKPslkcrkirs 180

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 19114622   158 -ETSNSSVKAISHFSGHK---RSIVSMEIGPGpIVSGRLYTASEDNTIRIWDVSTGN 210
Cdd:pfam08801 181 pSGGFSSLSIIPSVFGGGserEEIVSLRVDPS-RGERLLYTLTSKGVIQVWDLSSSG 236
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 165-205 2.10e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 2.10e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 19114622    165 KAISHFSGHKRSIVSMEIGPGpivSGRLYTASEDNTIRIWD 205
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPD---GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
165-205 3.66e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 3.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 19114622   165 KAISHFSGHKRSIVSMEIGPGpivSGRLYTASEDNTIRIWD 205
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD---GKLLASGSDDGTVKVWD 39
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 191-238 4.03e-03

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 39.25  E-value: 4.03e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 19114622   191 RLYT-ASEDNTIRIWDVSTGNLLTTiaLPS--TPSCMTVDPSERVVYVGNE 238
Cdd:TIGR03866  54 LLYVcASDSDTIQVIDPATGEVLHT--LPSgpDPEQFALHPNGKILYIANE 102
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 296-324 5.19e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 5.19e-03
                           10        20
                   ....*....|....*....|....*....
gi 19114622    296 QSPITTLTVSFDASLLISGDKDGNVLVWD 324
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
296-324 6.61e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 6.61e-03
                          10        20
                  ....*....|....*....|....*....
gi 19114622   296 QSPITTLTVSFDASLLISGDKDGNVLVWD 324
Cdd:pfam00400  11 TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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