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Conserved domains on  [gi|429238615|ref|NP_587790|]
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steroid oxidoreductase superfamily protein [Schizosaccharomyces pombe]

Protein Classification

phosphatidylethanolamine N-methyltransferase family domain-containing protein( domain architecture ID 229533)

phosphatidylethanolamine N-methyltransferase (PEMT) family domain-containing protein similar to Homo sapiens PEMT, which catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ICMT super family cl21511
Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine ...
 67-320 4.15e-80

Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology.


The actual alignment was detected with superfamily member pfam06966:

Pssm-ID: 473892  Cd Length: 235  Bit Score: 244.20  E-value: 4.15e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429238615   67 LWGVSVWTKNTSQVDRLWPILPTAFSLHFLFYGLGYniaSRRLMIMAFLQTLWSARLTYNYYRKGgYNRGaEDYRWVRVR 146
Cdd:pfam06966   1 FWAISRRTGNYSLVDVAWGGGFVLLAVLTLLLSEGA---TLRRMLVTVLVTLWGARLAWHLLRRN-WGWG-EDYRYVDLR 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429238615  147 QIMPKWIYPLFHYFyIHIFQVLHLYLLASPTYIAMLAGNERAFGAWDWIALELFMFMFVLEMLADQQQWDyyearnhynv 226
Cdd:pfam06966  76 KNWGKTPYLLRLLI-FFILQAVLLYIVSLPVYLANASGNNPAFGAWDIIGIAVWLVGFLFEALADQQLWA---------- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429238615  227 dktvpprFKYDLLSLGRgFNATGLFRWSRHPNFLAEQLIWLSFYLFGAIASESLLNWTIFA--WLGLVGVFQGSTRLTEK 304
Cdd:pfam06966 145 -------FKADPANRGK-FCDTGLWRYSRHPNYFGEALIWWGIFLIALNVLSGLEWWTIFGplVMTLLLVFVSGIPLTER 216

                         250
                  ....*....|....*....
gi 429238615  305 MSCEKY---PLYRVYQDKV 320
Cdd:pfam06966 217 SADKKYgdrEDYRAYQRTT 235
 
Name Accession Description Interval E-value
DUF1295 pfam06966
Protein of unknown function (DUF1295); This family contains a number of bacterial and ...
 67-320 4.15e-80

Protein of unknown function (DUF1295); This family contains a number of bacterial and eukaryotic proteins of unknown function that are approximately 300 residues long.


Pssm-ID: 399743  Cd Length: 235  Bit Score: 244.20  E-value: 4.15e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429238615   67 LWGVSVWTKNTSQVDRLWPILPTAFSLHFLFYGLGYniaSRRLMIMAFLQTLWSARLTYNYYRKGgYNRGaEDYRWVRVR 146
Cdd:pfam06966   1 FWAISRRTGNYSLVDVAWGGGFVLLAVLTLLLSEGA---TLRRMLVTVLVTLWGARLAWHLLRRN-WGWG-EDYRYVDLR 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429238615  147 QIMPKWIYPLFHYFyIHIFQVLHLYLLASPTYIAMLAGNERAFGAWDWIALELFMFMFVLEMLADQQQWDyyearnhynv 226
Cdd:pfam06966  76 KNWGKTPYLLRLLI-FFILQAVLLYIVSLPVYLANASGNNPAFGAWDIIGIAVWLVGFLFEALADQQLWA---------- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429238615  227 dktvpprFKYDLLSLGRgFNATGLFRWSRHPNFLAEQLIWLSFYLFGAIASESLLNWTIFA--WLGLVGVFQGSTRLTEK 304
Cdd:pfam06966 145 -------FKADPANRGK-FCDTGLWRYSRHPNYFGEALIWWGIFLIALNVLSGLEWWTIFGplVMTLLLVFVSGIPLTER 216

                         250
                  ....*....|....*....
gi 429238615  305 MSCEKY---PLYRVYQDKV 320
Cdd:pfam06966 217 SADKKYgdrEDYRAYQRTT 235
COG3752 COG3752
Steroid 5-alpha reductase family enzyme [General function prediction only];
52-326 6.53e-50

Steroid 5-alpha reductase family enzyme [General function prediction only];


Pssm-ID: 442966  Cd Length: 264  Bit Score: 167.32  E-value: 6.53e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429238615  52 PFVVGLLLSFILGNVLWGVSVWTKNTSQVDRLWPILPTAFSLHFLFYGLGYNIasrRLMIMAFLQTLWSARLTYNYYRKG 131
Cdd:COG3752    8 LLLLALAALLAVMLLAWLVSLRTRNASIVDVAWSLGFVLVALVYALLGDGDDA---RRLLVAALVTLWGLRLGGHLARRN 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429238615 132 GynRGAEDYRWVRVRQIMPKWiYPLFHYFYIHIFQVLHLYLLASPTYIAMLAGNERAFGAWDWIALELFMFMFVLEMLAD 211
Cdd:COG3752   85 R--GKGEDPRYAALRERWGRG-FALFSLFFVFLLQALLVWLVSLPVLAAAASPAPAPLGWLDVLGAALWLVGFAFEAVAD 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429238615 212 QQQWdyyearnhynvdktvppRFKYDLLSLGRgFNATGLFRWSRHPNFLAEQLIWLSFYLFGAIASesllnwtiFAWLGL 291
Cdd:COG3752  162 AQLA-----------------RFKADPANKGK-VCDTGLWRYSRHPNYFGEWLVWWGLALFALAAP--------PGWWTL 215

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 429238615 292 VG--------VFQGSTRLTEKMSCEKYPLYRVYQDKVGRFFPR 326
Cdd:COG3752  216 IGpllmtlllLKVSGIPLLEKHMLESRPAYREYQRRTSAFFPW 258
 
Name Accession Description Interval E-value
DUF1295 pfam06966
Protein of unknown function (DUF1295); This family contains a number of bacterial and ...
 67-320 4.15e-80

Protein of unknown function (DUF1295); This family contains a number of bacterial and eukaryotic proteins of unknown function that are approximately 300 residues long.


Pssm-ID: 399743  Cd Length: 235  Bit Score: 244.20  E-value: 4.15e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429238615   67 LWGVSVWTKNTSQVDRLWPILPTAFSLHFLFYGLGYniaSRRLMIMAFLQTLWSARLTYNYYRKGgYNRGaEDYRWVRVR 146
Cdd:pfam06966   1 FWAISRRTGNYSLVDVAWGGGFVLLAVLTLLLSEGA---TLRRMLVTVLVTLWGARLAWHLLRRN-WGWG-EDYRYVDLR 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429238615  147 QIMPKWIYPLFHYFyIHIFQVLHLYLLASPTYIAMLAGNERAFGAWDWIALELFMFMFVLEMLADQQQWDyyearnhynv 226
Cdd:pfam06966  76 KNWGKTPYLLRLLI-FFILQAVLLYIVSLPVYLANASGNNPAFGAWDIIGIAVWLVGFLFEALADQQLWA---------- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429238615  227 dktvpprFKYDLLSLGRgFNATGLFRWSRHPNFLAEQLIWLSFYLFGAIASESLLNWTIFA--WLGLVGVFQGSTRLTEK 304
Cdd:pfam06966 145 -------FKADPANRGK-FCDTGLWRYSRHPNYFGEALIWWGIFLIALNVLSGLEWWTIFGplVMTLLLVFVSGIPLTER 216

                         250
                  ....*....|....*....
gi 429238615  305 MSCEKY---PLYRVYQDKV 320
Cdd:pfam06966 217 SADKKYgdrEDYRAYQRTT 235
COG3752 COG3752
Steroid 5-alpha reductase family enzyme [General function prediction only];
52-326 6.53e-50

Steroid 5-alpha reductase family enzyme [General function prediction only];


Pssm-ID: 442966  Cd Length: 264  Bit Score: 167.32  E-value: 6.53e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429238615  52 PFVVGLLLSFILGNVLWGVSVWTKNTSQVDRLWPILPTAFSLHFLFYGLGYNIasrRLMIMAFLQTLWSARLTYNYYRKG 131
Cdd:COG3752    8 LLLLALAALLAVMLLAWLVSLRTRNASIVDVAWSLGFVLVALVYALLGDGDDA---RRLLVAALVTLWGLRLGGHLARRN 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429238615 132 GynRGAEDYRWVRVRQIMPKWiYPLFHYFYIHIFQVLHLYLLASPTYIAMLAGNERAFGAWDWIALELFMFMFVLEMLAD 211
Cdd:COG3752   85 R--GKGEDPRYAALRERWGRG-FALFSLFFVFLLQALLVWLVSLPVLAAAASPAPAPLGWLDVLGAALWLVGFAFEAVAD 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429238615 212 QQQWdyyearnhynvdktvppRFKYDLLSLGRgFNATGLFRWSRHPNFLAEQLIWLSFYLFGAIASesllnwtiFAWLGL 291
Cdd:COG3752  162 AQLA-----------------RFKADPANKGK-VCDTGLWRYSRHPNYFGEWLVWWGLALFALAAP--------PGWWTL 215

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 429238615 292 VG--------VFQGSTRLTEKMSCEKYPLYRVYQDKVGRFFPR 326
Cdd:COG3752  216 IGpllmtlllLKVSGIPLLEKHMLESRPAYREYQRRTSAFFPW 258
STE14 COG2020
Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein ...
 248-327 2.29e-07

Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441623 [Multi-domain]  Cd Length: 113  Bit Score: 48.62  E-value: 2.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429238615 248 TGLFRWSRHPNFLAEQLIWLSFylfgAIASESLlnWTIFAWLGLVGVFQGSTRLTEKMSCEKY-PLYRVYQDKVGRFFPR 326
Cdd:COG2020   39 TGPYRYVRHPMYLGFLLLLLGL----ALLLGSL--LALLLALLLLLLYVLRIRREERRLRARFgEEYRAYAARVPRLIPR 112


                 .
gi 429238615 327 L 327
Cdd:COG2020  113 L 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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