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Conserved domains on  [gi|24643268|ref|NP_573388|]
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isocitrate dehydrogenase 3a, isoform A [Drosophila melanogaster]

Protein Classification

isocitrate/isopropylmalate dehydrogenase family protein( domain architecture ID 296)

isocitrate/isopropylmalate dehydrogenase family protein such as isocitrate dehydrogenase that in the Krebs cycle catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate and CO2, and isopropylmalate dehydrogenase that in leucine biosynthesis catalyzes the oxidation and decarboxylation of 3-isopropyl-l-malate to 4-methyl-2-oxovalerate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Iso_dh super family cl00445
Isocitrate/isopropylmalate dehydrogenase;
23-354 0e+00

Isocitrate/isopropylmalate dehydrogenase;


The actual alignment was detected with superfamily member TIGR00175:

Pssm-ID: 444908  Cd Length: 333  Bit Score: 526.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268    23 GTKKVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDVTPVRgpDGKFGIPQAAIDSVNTNKIGLKGPLMTPVGKG-HR 101
Cdd:TIGR00175   2 GKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQT--DGKTEIPDEAVESIKRNKVALKGPLETPIGKGgHR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   102 SLNLALRKEFNLYANVRPCRSLEGYKTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASKRVAEYAFQYAK 181
Cdd:TIGR00175  80 SLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYAR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   182 NNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCAGLVG 261
Cdd:TIGR00175 160 KNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   262 GLGLTPSGNMGLNGALFE-SVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEGKYLTGDLGGR 340
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEpGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGT 319
                         330
                  ....*....|....
gi 24643268   341 AKCSEFTNEICAKL 354
Cdd:TIGR00175 320 ATTSDFTEAVIKRL 333
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
23-354 0e+00

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 526.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268    23 GTKKVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDVTPVRgpDGKFGIPQAAIDSVNTNKIGLKGPLMTPVGKG-HR 101
Cdd:TIGR00175   2 GKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQT--DGKTEIPDEAVESIKRNKVALKGPLETPIGKGgHR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   102 SLNLALRKEFNLYANVRPCRSLEGYKTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASKRVAEYAFQYAK 181
Cdd:TIGR00175  80 SLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYAR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   182 NNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCAGLVG 261
Cdd:TIGR00175 160 KNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   262 GLGLTPSGNMGLNGALFE-SVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEGKYLTGDLGGR 340
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEpGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGT 319
                         330
                  ....*....|....
gi 24643268   341 AKCSEFTNEICAKL 354
Cdd:TIGR00175 320 ATTSDFTEAVIKRL 333
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
11-354 0e+00

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 509.04  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   11 NATPAASRSYSSGTK--KVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDVTPVRGPDGKFGIPQAAIDSVNTNKIGL 88
Cdd:PLN00118  26 GAFSSSARAFSSSSTpiTATLFPGDGIGPEIAESVKQVFTAAGVPIEWEEHYVGTTVDPRTGSFLTWESLESVRRNKVGL 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   89 KGPLMTPVGKGHRSLNLALRKEFNLYANVRPCRSLEGYKTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEA 168
Cdd:PLN00118 106 KGPMATPIGKGHRSLNLTLRKELGLYANVRPCYSLPGYKTRYDDVDLVTIRENTEGEYSGLEHQVVRGVVESLKIITRQA 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  169 SKRVAEYAFQYAKNNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLY 248
Cdd:PLN00118 186 SLRVAEYAFHYAKTHGRKRVSAIHKANIMKKTDGLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVLVMPNLY 265
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  249 GDILSDMCAGLVGGLGLTPSGNMGLNG-ALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETI 327
Cdd:PLN00118 266 GDIISDLCAGLIGGLGLTPSCNIGENGlALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRHLKLNEQAEQIHNAILNTI 345
                        330       340
                 ....*....|....*....|....*..
gi 24643268  328 KEGKYLTGDLGGRAKCSEFTNEICAKL 354
Cdd:PLN00118 346 AEGKYRTADLGGSSTTTDFTKAICDHL 372
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
24-354 8.25e-157

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 443.30  E-value: 8.25e-157
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  24 TKKVTLIPGDGIGPEISAAVQKIFTAA----NVPIEWEAVDVtpvrgpdG-----KFG--IPQAAIDSVNTNKIGLKGPL 92
Cdd:COG0473   1 TYKIAVLPGDGIGPEVVAAALKVLEAAaerfGLDFEFEEADI-------GgaaydKTGtpLPDETLEALRKADAILLGAV 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  93 MTPV---GKGHRSLNLALRKEFNLYANVRPCRSLEGYKTLY-----DDVDVVTIRENTEGEYSGIEHEIVDG----VVQS 160
Cdd:COG0473  74 GGPKwddGVRPESGLLALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAID 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 161 IKLITEEASKRVAEYAFQYAKNNnRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYD 240
Cdd:COG0473 154 TRVYTRKGIERIARYAFELARKR-RKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFD 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 241 VLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNG-ALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKI 319
Cdd:COG0473 233 VIVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHLGEEEAADAI 312
                       330       340       350
                ....*....|....*....|....*....|....*
gi 24643268 320 ERAAFETIKEGkYLTGDLGGRAKCSEFTNEICAKL 354
Cdd:COG0473 313 EAAVEKVLAEG-VRTPDLGGKAGTSEMGDAIIAAL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
26-350 4.49e-135

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 388.58  E-value: 4.49e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268    26 KVTLIPGDGIGPEISAAVQKIFTAAN----VPIEWEAVDVTPVRGPDGKFGIPQAAIDSVNTNKIGLKGPLMTPVG--KG 99
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALekapLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWdpAG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   100 HRSLN--LALRKEFNLYANVRPCRSLEG------YKTLYDDVDVVTIRENTEGEYSGIEHEIVDG---VVQSIKLITEEA 168
Cdd:pfam00180  81 VRPENglLALRKELGLFANLRPAKVFPPlgdaspLKNEVEGVDIVIVRELTGGIYFGIEKGIKGSgneVAVDTKLYSRDE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   169 SKRVAEYAFQYAKNNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLY 248
Cdd:pfam00180 161 IERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   249 GDILSDMCAGLVGGLGLTPSGNMGLNG-ALFESVHGTAPDIAGKDLANPTALLLSAVMMLRH-MELNTYADKIERAAFET 326
Cdd:pfam00180 241 GDILSDEASMLTGSLGLLPSASLGANGfGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLKV 320
                         330       340
                  ....*....|....*....|....*..
gi 24643268   327 IKEGkYLTGDLGGRA---KCSEFTNEI 350
Cdd:pfam00180 321 LESG-IRTGDLAGSAtyvSTSEFGEAV 346
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
25-354 4.64e-113

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 332.08  E-value: 4.64e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   25 KKVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDVTpvRGPDGKFG--IPQAAIDSVNTNKIGLKGPLMTPvgKGHRS 102
Cdd:NF040626   2 YKITVIPGDGIGKEVMEAALYVLDALDLNFDFIEAEAG--RECFKKNGttIPEETIKIAKKSDATLFGAVTST--PGQKS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  103 LNLALRKEFNLYANVRPCRSLEGYKTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASKRVAEYAFQYAKN 182
Cdd:NF040626  78 PIITLRKELDLYANLRPIKSYEGINCLFKDLDFLIVRENTEGLYSGLEEEYTEEKAIAERVITRKASERICKFAFEYAIK 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  183 NNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCAGLVGG 262
Cdd:NF040626 158 LGRKKVTAVHKANVLKKTDGIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVIVTTNLFGDILSDEAAGLVGG 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  263 LGLTPSGNMGLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEGKYLTGDLGGRAK 342
Cdd:NF040626 238 LGLAPSANIGDKNGLFEPVHGSAPDIAGKNIANPIAMILSASMMLDYLGETYEANKLENALEKVLREGKVVTPDLGGNAK 317
                        330
                 ....*....|..
gi 24643268  343 CSEFTNEICAKL 354
Cdd:NF040626 318 TMEMANEIKKKI 329
AksF_Meth NF040619
homoisocitrate dehydrogenase;
26-350 5.43e-86

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 262.77  E-value: 5.43e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   26 KVTLIPGDGIGPEISAAVQKIFTaanvpiewEAVDVTPVRGPDG-----KFG--IPQAAIDSVNTNKIGLKGPLMTP--- 95
Cdd:NF040619   3 KICVIEGDGIGKEVIPETVRVLK--------ELGDFEFIKGEAGlecfkKYGdaIPEETIEKAKECDAILFGAVTTPkpt 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   96 --VGKGHRSLNLALRKEFNLYANVRPCRSLeGYKTLYDDVDVVTIRENTEGEYSGIE-HEIVDGVVQSIKLITEEASKRV 172
Cdd:NF040619  75 elKNKNYKSPILTLRKELDLYANVRPINNF-GDGQDVKNIDFVIIRENTEGLYVGREyYDEENEIAIAERIISKKGSERI 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  173 AEYAFQYAKNNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPE--IQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGD 250
Cdd:NF040619 154 IKFAFEYAKKNNRKKVSCIHKANVLRVTDGLFLEIFNEIKKKYKNfnIEADDYLVDATAMYLIKNPEMFDVIVTTNLFGD 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  251 ILSDMCAGLVGGLGLTPSGNMGLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIeRAAFETIKEG 330
Cdd:NF040619 234 ILSDEASGLIGGLGLAPSANIGDKKGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDYLGMKEKGDLI-REAVKKCLEN 312
                        330       340
                 ....*....|....*....|
gi 24643268  331 KYLTGDLGGRAKCSEFTNEI 350
Cdd:NF040619 313 GKVTPDLGGNLKTKEVTDKI 332
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
23-354 0e+00

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 526.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268    23 GTKKVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDVTPVRgpDGKFGIPQAAIDSVNTNKIGLKGPLMTPVGKG-HR 101
Cdd:TIGR00175   2 GKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQT--DGKTEIPDEAVESIKRNKVALKGPLETPIGKGgHR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   102 SLNLALRKEFNLYANVRPCRSLEGYKTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASKRVAEYAFQYAK 181
Cdd:TIGR00175  80 SLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYAR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   182 NNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCAGLVG 261
Cdd:TIGR00175 160 KNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   262 GLGLTPSGNMGLNGALFE-SVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEGKYLTGDLGGR 340
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEpGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGT 319
                         330
                  ....*....|....
gi 24643268   341 AKCSEFTNEICAKL 354
Cdd:TIGR00175 320 ATTSDFTEAVIKRL 333
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
11-354 0e+00

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 509.04  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   11 NATPAASRSYSSGTK--KVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDVTPVRGPDGKFGIPQAAIDSVNTNKIGL 88
Cdd:PLN00118  26 GAFSSSARAFSSSSTpiTATLFPGDGIGPEIAESVKQVFTAAGVPIEWEEHYVGTTVDPRTGSFLTWESLESVRRNKVGL 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   89 KGPLMTPVGKGHRSLNLALRKEFNLYANVRPCRSLEGYKTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEA 168
Cdd:PLN00118 106 KGPMATPIGKGHRSLNLTLRKELGLYANVRPCYSLPGYKTRYDDVDLVTIRENTEGEYSGLEHQVVRGVVESLKIITRQA 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  169 SKRVAEYAFQYAKNNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLY 248
Cdd:PLN00118 186 SLRVAEYAFHYAKTHGRKRVSAIHKANIMKKTDGLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVLVMPNLY 265
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  249 GDILSDMCAGLVGGLGLTPSGNMGLNG-ALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETI 327
Cdd:PLN00118 266 GDIISDLCAGLIGGLGLTPSCNIGENGlALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRHLKLNEQAEQIHNAILNTI 345
                        330       340
                 ....*....|....*....|....*..
gi 24643268  328 KEGKYLTGDLGGRAKCSEFTNEICAKL 354
Cdd:PLN00118 346 AEGKYRTADLGGSSTTTDFTKAICDHL 372
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
24-354 8.25e-157

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 443.30  E-value: 8.25e-157
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  24 TKKVTLIPGDGIGPEISAAVQKIFTAA----NVPIEWEAVDVtpvrgpdG-----KFG--IPQAAIDSVNTNKIGLKGPL 92
Cdd:COG0473   1 TYKIAVLPGDGIGPEVVAAALKVLEAAaerfGLDFEFEEADI-------GgaaydKTGtpLPDETLEALRKADAILLGAV 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  93 MTPV---GKGHRSLNLALRKEFNLYANVRPCRSLEGYKTLY-----DDVDVVTIRENTEGEYSGIEHEIVDG----VVQS 160
Cdd:COG0473  74 GGPKwddGVRPESGLLALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAID 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 161 IKLITEEASKRVAEYAFQYAKNNnRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYD 240
Cdd:COG0473 154 TRVYTRKGIERIARYAFELARKR-RKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFD 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 241 VLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNG-ALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKI 319
Cdd:COG0473 233 VIVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHLGEEEAADAI 312
                       330       340       350
                ....*....|....*....|....*....|....*
gi 24643268 320 ERAAFETIKEGkYLTGDLGGRAKCSEFTNEICAKL 354
Cdd:COG0473 313 EAAVEKVLAEG-VRTPDLGGKAGTSEMGDAIIAAL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
26-350 4.49e-135

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 388.58  E-value: 4.49e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268    26 KVTLIPGDGIGPEISAAVQKIFTAAN----VPIEWEAVDVTPVRGPDGKFGIPQAAIDSVNTNKIGLKGPLMTPVG--KG 99
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALekapLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWdpAG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   100 HRSLN--LALRKEFNLYANVRPCRSLEG------YKTLYDDVDVVTIRENTEGEYSGIEHEIVDG---VVQSIKLITEEA 168
Cdd:pfam00180  81 VRPENglLALRKELGLFANLRPAKVFPPlgdaspLKNEVEGVDIVIVRELTGGIYFGIEKGIKGSgneVAVDTKLYSRDE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   169 SKRVAEYAFQYAKNNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLY 248
Cdd:pfam00180 161 IERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   249 GDILSDMCAGLVGGLGLTPSGNMGLNG-ALFESVHGTAPDIAGKDLANPTALLLSAVMMLRH-MELNTYADKIERAAFET 326
Cdd:pfam00180 241 GDILSDEASMLTGSLGLLPSASLGANGfGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLKV 320
                         330       340
                  ....*....|....*....|....*..
gi 24643268   327 IKEGkYLTGDLGGRA---KCSEFTNEI 350
Cdd:pfam00180 321 LESG-IRTGDLAGSAtyvSTSEFGEAV 346
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
25-354 1.70e-134

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 391.95  E-value: 1.70e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   25 KKVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDVTP---VRGPDGkfGIPQAAIDSVNTNKIGLKGPLMTPVGKGHR 101
Cdd:PRK09222   5 TPITVAYGDGIGPEIMEAVLKILEAAGAPLEIETIEIGEkvyKKGWTS--GISPSAWESIRRTKVLLKAPITTPQGGGYK 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  102 SLNLALRKEFNLYANVRPCRSLEGY-KTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASKRVAEYAFQYA 180
Cdd:PRK09222  83 SLNVTLRKTLGLYANVRPCVSYHPFvETKHPNLDVVIIRENEEDLYAGIEHRQTPDVYQCLKLISRPGSEKIIRYAFEYA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  181 KNNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCAGLV 260
Cdd:PRK09222 163 RANGRKKVTCLTKDNIMKLTDGLFHKVFDEIAKEYPDIEAEHYIVDIGAARLATNPENFDVIVTPNLYGDILSDIAAEIS 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  261 GGLGLTPSGNMGLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEGkYLTGDLGGR 340
Cdd:PRK09222 243 GSVGLAGSANIGEEYAMFEAVHGSAPDIAGKNIANPSGLLNAAVMMLVHIGQFDIAELIENAWLKTLEDG-IHTADIYNE 321
                        330       340
                 ....*....|....*....|
gi 24643268  341 AKCS------EFTNEICAKL 354
Cdd:PRK09222 322 GVSKkkvgtkEFAEAVIENL 341
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
24-354 2.33e-134

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 386.00  E-value: 2.33e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   24 TKKVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDVTPVRGPDGKFGIPQAAIDSVNTNKIGLKGPLMTPVGKGHRSL 103
Cdd:PRK08997   2 KQTITVIPGDGIGPSIIDATLKILDKLGCDFEYEFADAGLTALEKHGELLPQRTLDLIEKNKIALKGPLTTPVGEGFTSI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  104 NLALRKEFNLYANVRPCRSLEGYKTLYDDVDVVTIRENTEGEYSGIEHEIV-DG-VVQSIKLITEEASKRVAEYAFQYAK 181
Cdd:PRK08997  82 NVTLRKKFDLYANVRPVLSFPGTKARYDNIDIITVRENTEGMYSGEGQTVSeDGeTAEATSIITRKGAERIVRFAYELAR 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  182 NNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCAGLVG 261
Cdd:PRK08997 162 KEGRKKVTAVHKANIMKSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDLCAGLVG 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  262 GLGLTPSGNMGLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEGKYLTGDLGGRA 341
Cdd:PRK08997 242 GLGMAPGANIGRDAAIFEAVHGSAPDIAGKNLANPTSVILAAIQMLEYLGMPDKAERIRKAIVAVIEAGDRTTRDLGGTH 321
                        330
                 ....*....|...
gi 24643268  342 KCSEFTNEICAKL 354
Cdd:PRK08997 322 GTTDFTQAVIDRL 334
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
27-354 1.78e-126

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 367.27  E-value: 1.78e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   27 VTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDVTpvrgpDGKFGIPQAAIDSVNTNKIGLKGPLMTPVGKGHRSLNLA 106
Cdd:PLN00123  33 VTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERYEVH-----GDMKKVPEEVLESIRRNKVCLKGGLATPVGGGVSSLNVQ 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  107 LRKEFNLYANVRPCRSLEGYKTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASKRVAEYAFQYAKNNNRK 186
Cdd:PLN00123 108 LRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAYLNNRK 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  187 KVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCAGLVGGLGLT 266
Cdd:PLN00123 188 KVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANTAAGIAGGTGVM 267
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  267 PSGNMGLNGALFESVHGTA----PDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEGKYLTGDLGGRAK 342
Cdd:PLN00123 268 PGGNVGADHAVFEQGASAGnvgnEKLVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGKYRTKDLGGSST 347
                        330
                 ....*....|..
gi 24643268  343 CSEFTNEICAKL 354
Cdd:PLN00123 348 TQEVVDAVIANL 359
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
25-354 4.64e-113

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 332.08  E-value: 4.64e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   25 KKVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDVTpvRGPDGKFG--IPQAAIDSVNTNKIGLKGPLMTPvgKGHRS 102
Cdd:NF040626   2 YKITVIPGDGIGKEVMEAALYVLDALDLNFDFIEAEAG--RECFKKNGttIPEETIKIAKKSDATLFGAVTST--PGQKS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  103 LNLALRKEFNLYANVRPCRSLEGYKTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASKRVAEYAFQYAKN 182
Cdd:NF040626  78 PIITLRKELDLYANLRPIKSYEGINCLFKDLDFLIVRENTEGLYSGLEEEYTEEKAIAERVITRKASERICKFAFEYAIK 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  183 NNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCAGLVGG 262
Cdd:NF040626 158 LGRKKVTAVHKANVLKKTDGIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVIVTTNLFGDILSDEAAGLVGG 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  263 LGLTPSGNMGLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEGKYLTGDLGGRAK 342
Cdd:NF040626 238 LGLAPSANIGDKNGLFEPVHGSAPDIAGKNIANPIAMILSASMMLDYLGETYEANKLENALEKVLREGKVVTPDLGGNAK 317
                        330
                 ....*....|..
gi 24643268  343 CSEFTNEICAKL 354
Cdd:NF040626 318 TMEMANEIKKKI 329
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
25-354 9.50e-108

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 318.23  E-value: 9.50e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   25 KKVTLIPGDGIGPEISAAVQKIFTAANVPIEW---EAVDVTPVRgpDGKfGIPQAAIDSVNTNKIGLKGPlmtpVGKGHR 101
Cdd:PRK14025   2 HKICVIEGDGIGKEVVPAALHVLEATGLPFEFvyaEAGDEVFEK--TGK-ALPEETIEAAKEADAVLFGA----AGETAA 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  102 SLNLALRKEFNLYANVRPCRSLEGYKTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASKRVAEYAFQYAK 181
Cdd:PRK14025  75 DVIVKLRRILDTYANVRPVKSYKGVKCLYPDIDYVIVRENTEGLYKGIEAEIADGVTVATRVITRKASERIFRFAFEMAK 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  182 N----NNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCA 257
Cdd:PRK14025 155 RrkkmGKEGKVTCAHKANVLKKTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFGDILSDGAA 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  258 GLVGGLGLTPSGNMGLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEGKyLTGDL 337
Cdd:PRK14025 235 GLVGGLGLAPSANIGDKYGLFEPVHGSAPDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEEVLALGL-TTPDL 313
                        330
                 ....*....|....*..
gi 24643268  338 GGRAKCSEFTNEICAKL 354
Cdd:PRK14025 314 GGNLSTMEMAEEVAKRV 330
LEU3_arch TIGR02088
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ...
27-350 3.90e-107

isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.


Pssm-ID: 273962  Cd Length: 322  Bit Score: 316.71  E-value: 3.90e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268    27 VTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDVTPVRGPDGKFGIPQAAIDSVNTNKIGLKGPLMTPVGKGHRSLNLA 106
Cdd:TIGR02088   1 VAVIPGDGIGPEVIEAAIRILNKLGLEIEFIEFEAGDEALKKYGSALPEDTLEEIRKADAILFGAVTTPANPGYKSVIVT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   107 LRKEFNLYANVRPCRSLEGYKTLY-DDVDVVTIRENTEGEYSGIEhEIVDGVVQSIKLITEEASKRVAEYAFQYAKNNNR 185
Cdd:TIGR02088  81 LRKELDLYANVRPAKSLPGIPDLYpNGKDIVIVRENTEGLYAGFE-FGFSDRAIAIRVITREGSERIARFAFNLAKERNR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   186 KkVTVVHKANIMRMSDGLFLRCVRDMAQKFpEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCAGLVGGLGL 265
Cdd:TIGR02088 160 K-VTCVHKANVLKGTDGLFREVCREIAKRY-GVEYRDMYVDSAAMNLVKDPWRFDVIVTTNMFGDILSDLASALAGSLGL 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   266 TPSGNMGLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEGkYLTGDLGGRAKCSE 345
Cdd:TIGR02088 238 APSANIGDRKALFEPVHGSAPDIAGKGIANPTAAILSVAMMLDYLGELEKGKLVWEAVEYYIIEG-KKTPDLGGTAKTKE 316

                  ....*
gi 24643268   346 FTNEI 350
Cdd:TIGR02088 317 VGDEI 321
ICDH_alpha TIGR02924
isocitrate dehydrogenase; This family of mainly alphaproteobacterial enzymes is a member of ...
26-354 4.15e-107

isocitrate dehydrogenase; This family of mainly alphaproteobacterial enzymes is a member of the isocitrate/isopropylmalate dehydrogenase superfamily described by pfam00180. Every member of the seed of this model appears to have a TCA cycle lacking only a determined isocitrate dehydrogenase. The precise identity of the cofactor (NADH -- 1.1.1.41 vs. NADPH -- 1.1.1.42) is unclear. [Energy metabolism, TCA cycle]


Pssm-ID: 274353 [Multi-domain]  Cd Length: 473  Bit Score: 321.71  E-value: 4.15e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268    26 KVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDV-TPVRGPDGKFGIPQAAIDSVNTNKIGLKGPLMTPVGKGHRSLN 104
Cdd:TIGR02924   2 PITVAYGDGIGPEIMEAVLLILKEAEAPIDIETIEIgEKVYKKGWPSGISPSSWESIRRTKVLLKAPITTPQGGGHKSLN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   105 LALRKEFNLYANVRPCRSLEGY-KTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASKRVAEYAFQYAKNN 183
Cdd:TIGR02924  82 VTLRKTLGLYANIRPCVSYHPFiETKSPNLNIVIVRENEEDLYTGIEYRQTPDTYECTKLITRSGSEKICRYAFEYARKH 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   184 NRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCAGLVGGL 263
Cdd:TIGR02924 162 NRKKVTCLTKDNIMKMTDGIFHKIFDKIAAEYPDIESEHYIVDIGMARLATNPENFDVIVTPNLYGDILSDVAAEISGSV 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   264 GLTPSGNMGLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEGKYlTGDL------ 337
Cdd:TIGR02924 242 GLAGSANIGEEYAMFEAVHGSAPDIAGQNIANPSGLLNAAIQMLVHIGQSDIAQLIYNAWLKTLEDGVH-TADIynekts 320
                         330
                  ....*....|....*..
gi 24643268   338 GGRAKCSEFTNEICAKL 354
Cdd:TIGR02924 321 KQKVGTKEFAEAVTANL 337
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
30-354 2.86e-92

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 281.61  E-value: 2.86e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  30 IPGDGIGPEISAAVQKIFTAA-------NVPIEWEAVDVtpvrgpdG-----KFG--IPQAAIDSVNTNKIGLKGPLMTP 95
Cdd:COG0538  24 IEGDGIGPEITRAIWKVIDAAvekayggKRDIEWKEVDA-------GekardETGdwLPDETAEAIKEYGVGIKGPLTTP 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  96 VGKGHRSLNLALRKEFNLYANVRPCRSLEGYKTL---YDDVDVVTIRENTEGEYSGIE--------------------HE 152
Cdd:COG0538  97 VGGGWRSLNVTIRQILDLYVCRRPVRYFKGVPSPvkhPEKVDIVIFRENTEDIYAGIEwkagspealkliffledemgVT 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 153 IVD-----GVVqsIKLITEEASKRVAEYAFQYAKNNNRKKVTVVHKANIMRMSDGLFlrcvRDMAQKFPEIQFEEK---- 223
Cdd:COG0538 177 VIRfpedsGIG--IKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAF----KDWGYEVAEEEFGDKfite 250
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 224 ----------------YLDTVCLNMVQN----PGKYDVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNG-ALFESVH 282
Cdd:COG0538 251 gpwekykgpkpagkivYKDRIADDMLQQillrPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGDDGgAEFEATH 330
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24643268 283 GTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIkEGKYLTGDL-----GGRA-KCSEFTNEICAKL 354
Cdd:COG0538 331 GTAPKYAGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTI-ESGKVTYDLarlmeGATElSTSEFGDAIIENL 407
AksF_Meth NF040619
homoisocitrate dehydrogenase;
26-350 5.43e-86

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 262.77  E-value: 5.43e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   26 KVTLIPGDGIGPEISAAVQKIFTaanvpiewEAVDVTPVRGPDG-----KFG--IPQAAIDSVNTNKIGLKGPLMTP--- 95
Cdd:NF040619   3 KICVIEGDGIGKEVIPETVRVLK--------ELGDFEFIKGEAGlecfkKYGdaIPEETIEKAKECDAILFGAVTTPkpt 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   96 --VGKGHRSLNLALRKEFNLYANVRPCRSLeGYKTLYDDVDVVTIRENTEGEYSGIE-HEIVDGVVQSIKLITEEASKRV 172
Cdd:NF040619  75 elKNKNYKSPILTLRKELDLYANVRPINNF-GDGQDVKNIDFVIIRENTEGLYVGREyYDEENEIAIAERIISKKGSERI 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  173 AEYAFQYAKNNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPE--IQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGD 250
Cdd:NF040619 154 IKFAFEYAKKNNRKKVSCIHKANVLRVTDGLFLEIFNEIKKKYKNfnIEADDYLVDATAMYLIKNPEMFDVIVTTNLFGD 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  251 ILSDMCAGLVGGLGLTPSGNMGLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIeRAAFETIKEG 330
Cdd:NF040619 234 ILSDEASGLIGGLGLAPSANIGDKKGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDYLGMKEKGDLI-REAVKKCLEN 312
                        330       340
                 ....*....|....*....|
gi 24643268  331 KYLTGDLGGRAKCSEFTNEI 350
Cdd:NF040619 313 GKVTPDLGGNLKTKEVTDKI 332
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
24-354 6.59e-83

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 255.80  E-value: 6.59e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   24 TKKVTLIPGDGIGPEISAAVQKIFTAA----NVPIEWE-------AVDVTPVRGPDGKFGIPQAAiDSVntnkiglkgpL 92
Cdd:PRK00772   2 TYKIAVLPGDGIGPEVMAEAVKVLDAVaekfGFDFEFEealvggaAIDAHGVPLPEETLEACRAA-DAV----------L 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   93 MTPVG-----------KGHRSLnLALRKEFNLYANVRPCR---SLEGYKTLYDDV----DVVTIRENTEGEYSG----IE 150
Cdd:PRK00772  71 LGAVGgpkwdnlppdvRPERGL-LALRKELGLFANLRPAKlypGLADASPLKPEIvaglDILIVRELTGGIYFGeprgRE 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  151 HEIVDGVVQSIKLITEEASKRVAEYAFQYAKNNnRKKVTVVHKANIMRmSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCL 230
Cdd:PRK00772 150 GLGGEERAFDTMVYTREEIERIARVAFELARKR-RKKVTSVDKANVLE-SSRLWREVVTEVAKEYPDVELSHMYVDNAAM 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  231 NMVQNPGKYDVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNG-ALFESVHGTAPDIAGKDLANPTALLLSAVMMLRH 309
Cdd:PRK00772 228 QLVRNPKQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLGESGpGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRY 307
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 24643268  310 -MELNTYADKIERAAFETIKEGkYLTGDL---GGRAKCSEFTNEICAKL 354
Cdd:PRK00772 308 sLGLEEAADAIEAAVEKVLAQG-YRTADIaegGGKVSTSEMGDAILAAL 355
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
30-350 1.53e-75

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 238.81  E-value: 1.53e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   30 IPGDGIGPEISAAVQKIFTAA-------NVPIEWEAV----DVTPVRGPDgkFGIPQAAIDSVNTNKIGLKGPLMTPVGK 98
Cdd:PRK07006  25 IEGDGIGPDITPAMLKVVDAAvekaykgERKISWMEIyageKATKVYGED--VWLPEETLDLIREYRVAIKGPLTTPVGG 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   99 GHRSLNLALRKEFNLYANVRPCRSLEGYKTLY---DDVDVVTIRENTEGEYSGIEHEI----VDGVVQ------------ 159
Cdd:PRK07006 103 GIRSLNVALRQELDLYVCLRPVRYFKGVPSPVkrpEDTDMVIFRENSEDIYAGIEWKAgsaeAKKVIKflqeemgvkkir 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  160 -------SIKLITEEASKRVAEYAFQYAKNNNRKKVTVVHKANIMRMSDGLFlrcvRDMAQKFPEIQFEEKYLDTVCLNM 232
Cdd:PRK07006 183 fpetsgiGIKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAF----KDWGYQLAEEEFGDELIDGGPWDK 258
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  233 VQN------------------------PGKYDVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNGALFESVHGTAPDI 288
Cdd:PRK07006 259 IKNpetgkeiivkdsiadaflqqillrPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANINDGHAIFEATHGTAPKY 338
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24643268  289 AGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEgKYLTGDL------GGRAKCSEFTNEI 350
Cdd:PRK07006 339 AGLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTIAS-KTVTYDFarlmegATEVKCSEFGDAL 405
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
21-350 3.46e-69

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 220.18  E-value: 3.46e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   21 SSGTKKVTLIPGDGIGPEISAAVQKIFTAAnvpieweAVDVTPVRGPDGKFG----------IPQAAIDSVNTNK---IG 87
Cdd:PRK03437   1 MAKTMKLAVIPGDGIGPEVVAEALKVLDAV-------AAGGPGVETTEYDLGarrylrtgetLPDSVLAELRQHDailLG 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   88 LKGPLMTPVGKGHRSLNLALRKEFNLYANVRPCRSLEGYKT-LYD--DVDVVTIRENTEGEYSGI--------EHEIVDG 156
Cdd:PRK03437  74 AIGDPSVPSGVLERGLLLKLRFALDHYVNLRPSKLYPGVTSpLAGpgDIDFVVVREGTEGPYTGNggalrvgtPHEVATE 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  157 VvqSIKliTEEASKRVAEYAFQYAKNNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNP 236
Cdd:PRK03437 154 V--SVN--TAFGVERVVRDAFERAQKRPRKHLTLVHKTNVLTFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTDP 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  237 GKYDVLVMPNLYGDILSDMCAGLVGGLGLTPSGNM---GLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELN 313
Cdd:PRK03437 230 SRFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNInptGTNPSMFEPVHGSAPDIAGQGIADPTAAILSVALLLDHLGEE 309
                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 24643268  314 TYADKIERAafetikegkyLTGDLGGRAKCSEFTNEI 350
Cdd:PRK03437 310 DAAARIEAA----------VEADLAERGKMGRSTAEV 336
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
26-350 1.11e-68

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 218.81  E-value: 1.11e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268    26 KVTLIPGDGIGPEISAAVQKI-----------FTAANVPIEWEAVDVTPVRGPDGKFGIPQAAiDSVNTNKIGlkGPLMT 94
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVlkavaerfglkFEFEEHLIGGAAIDATGQPLPEETLKGCKEA-DAVLLGAVG--GPKWD 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268    95 PVGKGHRSLN--LALRKEFNLYANVRPCR---SLEGYKTLYDD----VDVVTIRENTEGEYSGIEHEI-VDGVVQSIKLI 164
Cdd:TIGR00169  78 NLPRDQRPEQglLKLRKSLDLFANLRPAKvfpGLEDLSPLKEEiakgVDFVVVRELTGGIYFGEPKGReGEGEAWDTEVY 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   165 TEEASKRVAEYAFQYAKNNnRKKVTVVHKANIMRMSDgLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVM 244
Cdd:TIGR00169 158 TVPEIERIARVAFEMARKR-RKKVTSVDKANVLESSR-LWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVT 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   245 PNLYGDILSDMCAGLVGGLGLTPSGNMGLNG-ALFESVHGTAPDIAGKDLANPTALLLSAVMMLRH-MELNTYADKIERA 322
Cdd:TIGR00169 236 SNLFGDILSDEASVITGSLGMLPSASLGSDGfGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYsFNLEEAADAIEAA 315
                         330       340
                  ....*....|....*....|....*...
gi 24643268   323 AFETIKEGKYlTGDLGGRAKCSEFTNEI 350
Cdd:TIGR00169 316 VKKVLAEGYR-TPDLGSSATTAVGTAEM 342
TTC TIGR02089
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ...
26-354 4.84e-68

tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]


Pssm-ID: 273963  Cd Length: 352  Bit Score: 217.39  E-value: 4.84e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268    26 KVTLIPGDGIGPEISAAVQKIFTAA------------NVPIEWEAVDVTPVRGP-DGKFGIPQaaIDSVNTNKIGlkGPL 92
Cdd:TIGR02089   5 RIAAIPGDGIGKEVVAAALQVLEAAakrhggfslhftEFPWSCDYYKEHGKMMPeDGLEKLKK--FDAIFLGAVG--WPA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268    93 MTPVGKGHRSLNLALRKEFNLYANVRPCRSLEGYKT-----LYDDVDVVTIRENTEGEYSGIEHEIVDG----VVQSIKL 163
Cdd:TIGR02089  81 LVPDHISLWGLLLKIRREFDQYANVRPAKLLPGVTSplrncGPGDFDFVVVRENSEGEYSGVGGRIHRGtdeeVATQNAI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   164 ITEEASKRVAEYAFQYAKNNnRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLV 243
Cdd:TIGR02089 161 FTRKGVERIMRFAFELAQKR-RKHLTSATKSNGIRHSMPFWDEVFAEVAAEYPDVEWDSYHIDALAARFVLKPETFDVIV 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   244 MPNLYGDILSDMCAGLVGGLGLTPSGNMGLNG---ALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIe 320
Cdd:TIGR02089 240 ASNLFGDILSDLGAALMGSLGVAPSANINPEGkfpSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEHLGEKEAGAKI- 318
                         330       340       350
                  ....*....|....*....|....*....|....
gi 24643268   321 RAAFETIKEGKYLTGDLGGRAKCSEFTNEICAKL 354
Cdd:TIGR02089 319 MDAIERVTAAGILTPDVGGKATTSEVTEAVCNAL 352
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
25-337 4.15e-67

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 217.01  E-value: 4.15e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   25 KKVTL-IPGDGIGPEISAAVQKIFTAA-------NVPIEWeaVDVTPVRGPDGKFG--IPQAAIDSVNTNKIGLKGPLMT 94
Cdd:PRK06451  23 KPIILyVEGDGIGPEITHAAMKVINKAvekaygsDREIKW--VEVLAGDKAEKLTGnrFPKESEELIEKYRVLLKGPLET 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   95 PVGKGHRSLNLALRKEFNLYANVRPCRSLEGYKTLY---DDVDVVTIRENTEGEYSGIEH-------------------- 151
Cdd:PRK06451 101 PIGKGWKSINVAIRLMLDLYANIRPVKYIPGIESPLknpEKIDLIIFRENTDDLYRGIEYpydseeakkirdflrkelgv 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  152 EIVDGVVQSIKLITEEASKRVAEYAFQYAKNNNRKKVTVVHKANIMRMSDGLF--------LRCVRD-------MAQKFP 216
Cdd:PRK06451 181 EVEDDTGIGIKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFrewayevaLKEFRDyvvteeeVTKNYN 260
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  217 EIQFEEKYL--DTVCLNMVQN----PGKYDVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNGALFESVHGTAPDIAG 290
Cdd:PRK06451 261 GVPPSGKVIinDRIADNMFQQiiirPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTGGMFEAIHGTAPKYAG 340
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 24643268  291 KDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEGKyLTGDL 337
Cdd:PRK06451 341 KNVANPTGIIKGGELMLRFMGWDKAADLIDKAIMESIKQKK-VTQDL 386
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
26-354 1.73e-61

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 200.72  E-value: 1.73e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   26 KVTLIPGDGIGPEISAAVQKIFTAAN----------VPIEW------EAVDVTPvrgpdgKFGIPQ-AAIDSVNTNKIGl 88
Cdd:PRK08194   5 KIAVIPGDGVGKEVVPAAVRVLKAVAevhgglkfefTEFPWsceyylEHGEMMP------EDGLEQlKQFDAIFLGAVG- 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   89 kGPLMTPvgkGHRSL---NLALRKEFNLYANVRPCRSLEGYKTLY---DDVDVVTIRENTEGEYSGI-------EHEIVd 155
Cdd:PRK08194  78 -NPKLVP---DHISLwglLIKIRREFEQVINIRPAKQLRGIKSPLanpKDFDLLVVRENSEGEYSEVggrihrgEDEIA- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  156 gvVQSiKLITEEASKRVAEYAFQYAKNNnRKKVTVVHKAN----IMRMSDGLFlrcvRDMAQKFPEIQFEEKYLDTVCLN 231
Cdd:PRK08194 153 --IQN-AVFTRKGTERAMRYAFELAAKR-RKHVTSATKSNgivhSMPFWDEVF----QEVGKDYPEIETDSQHIDALAAF 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  232 MVQNPGKYDVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNG---ALFESVHGTAPDIAGKDLANPTALLLSAVMMLR 308
Cdd:PRK08194 225 FVTRPEEFDVIVASNLFGDILTDIGAAIMGSIGIAPAANINVNGkypSMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLD 304
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 24643268  309 HMELNTYADKIERAAFETIKEGkYLTGDLGGRAKCSEFTNEICAKL 354
Cdd:PRK08194 305 HFGEEELGSHLLDVIEDVTEDG-IKTPDIGGRATTDEVTDEIISRL 349
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
27-350 1.85e-57

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 193.39  E-value: 1.85e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   27 VTLIPGDGIGPEISAAVQKIFTAA-------NVPIEW-------EAVDVTpvrgpdGKFG-IPQAAIDSVNTNKIGLKGP 91
Cdd:PRK07362  31 IPFIRGDGTGVDIWPATQKVLDAAvakayggERKINWfkvyagdEACDLY------GTYQyLPEDTLEAIREYGVAIKGP 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   92 LMTPVGKGHRSLNLALRKEFNLYANVRPCRSLEGYKTLY---DDVDVVTIRENTEGEYSGIEHEIVDGVVQS-------- 160
Cdd:PRK07362 105 LTTPIGGGIRSLNVALRQIFDLYSCVRPCRYYAGTPSPHknpEKLDVIVYRENTEDIYMGIEWEAGDEIGDKlikhlnee 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  161 --------------------IKLITEEASKRVAEYAFQYAK--NNNRKKVTVVHKANIMRMSDGLF-----------LR- 206
Cdd:PRK07362 185 vipaspelgkrqiplgsgigIKPVSKTGSQRHIRRAIEHALrlPGDKRHVTLVHKGNIMKYTEGAFrdwgyelatteFRd 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  207 -CVRDMA-------QKFPEIQFEE--------------------------------------KYLDTVCLN--------- 231
Cdd:PRK07362 265 eCVTEREswilsnkEKNPNISIEDnarmiepgydsltpekkaaicaevkevldsiwsshgngKWKEKVLVDdriadsifq 344
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  232 MVQN-PGKYDVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHM 310
Cdd:PRK07362 345 QIQTrPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAAIFEATHGTAPKHAGLDRINPGSVILSGVMMLEYL 424
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 24643268  311 ELNTYADKIERAAFETIKEGKyLTGDLG-------GRAKCSEFTNEI 350
Cdd:PRK07362 425 GWQEAADLITKGLSAAIANKQ-VTYDLArlmeppvDPLSCSEFAEAI 470
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
27-337 2.83e-39

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 143.67  E-value: 2.83e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   27 VTLIPGDGIGPEISAAVQKIFTAA-----------NVPIEWEAVDVTPVRGPDGKFgipqAAIDSVNTNKIGLKGPLMTP 95
Cdd:PLN02329  49 IALLPGDGIGPEVISVAKNVLQKAgsleglefdfqEMPVGGAALDLVGVPLPEETF----TAAKQSDAILLGAIGGYKWD 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268   96 VGKGHRSLNLAL---RKEFNLYANVRPCRSLEGY-------KTLYDDVDVVTIRENTEGEYSGIEHEIV-----DGVVQS 160
Cdd:PLN02329 125 KNEKHLRPEMALfylRRDLKVFANLRPATVLPQLvdastlkKEVAEGVDMMIVRELTGGIYFGEPRGITinengEEVGVS 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  161 IKLITEEASKRVAEYAFQYAKNNnRKKVTVVHKANIMRMSDgLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYD 240
Cdd:PLN02329 205 TEIYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFD 282
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  241 VLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNG-ALFESVHGTAPDIAGKDLANPTALLLSAVMMLRH-MELNTYADK 318
Cdd:PLN02329 283 TIVTNNIFGDILSDEASMITGSIGMLPSASLGESGpGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAKR 362
                        330
                 ....*....|....*....
gi 24643268  319 IERAAFETIKEGkYLTGDL 337
Cdd:PLN02329 363 IEDAVVDALNKG-FRTGDI 380
PRK08299 PRK08299
NADP-dependent isocitrate dehydrogenase;
149-337 1.56e-05

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236226  Cd Length: 402  Bit Score: 46.39  E-value: 1.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  149 IEHEIVD----GVVQSIKlITEEASKRVAEYAFQYAKNNNrKKVTVVHKANIMRMSDGLFlrcvRDMAQKFPEIQFEEKY 224
Cdd:PRK08299 164 IEHEVHDfpgaGVAMGMY-NLDESIRDFARASFNYGLDRK-YPVYLSTKNTILKAYDGRF----KDIFQEVYEAEFKEKF 237
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  225 -----------LDTVCLNMVQNPGKYdVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNGALFES--VHGTAPD---- 287
Cdd:PRK08299 238 eaagityehrlIDDMVASALKWEGGY-VWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKTVEAeaAHGTVTRhyrq 316
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 24643268  288 -IAGKDLA-NPTALLLSAVMMLRH-------MELNTYADKIERAAFETIKEGKyLTGDL 337
Cdd:PRK08299 317 hQKGEETStNPIASIFAWTRGLAHrgkldgnPELVKFADTLEKVCIETVESGF-MTKDL 374
PLN03065 PLN03065
isocitrate dehydrogenase (NADP+); Provisional
165-337 1.57e-05

isocitrate dehydrogenase (NADP+); Provisional


Pssm-ID: 178617 [Multi-domain]  Cd Length: 483  Bit Score: 46.41  E-value: 1.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  165 TEEASKRVAEYAFQYAKNnnrKK--VTVVHKANIMRMSDGLFLRCVRDM-----AQKFPE--IQFEEKYLDTVCLNMVQN 235
Cdd:PLN03065 254 VDESIRAFAESSMAMALQ---KKwpLYLSTKNTILKKYDGRFKDIFQEVyeeqwKQKFEEhsIWYEHRLIDDMVAYAVKS 330
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  236 PGKYdVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNGALFES--VHGTAPD-----IAGKDLA-NPTALLLSAVMML 307
Cdd:PLN03065 331 EGGY-VWACKNYDGDVQSDLLAQGFGSLGLMTSVLLSSDGKTLEAeaAHGTVTRhfrlhQKGQETStNSIASIFAWTRGL 409
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 24643268  308 RHM-------ELNTYADKIERAAFETIKEGKyLTGDL 337
Cdd:PLN03065 410 EHRakldkneELLDFVHKLESACIETVESGK-MTKDL 445
PTZ00435 PTZ00435
isocitrate dehydrogenase; Provisional
165-337 9.70e-05

isocitrate dehydrogenase; Provisional


Pssm-ID: 240417  Cd Length: 413  Bit Score: 43.82  E-value: 9.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  165 TEEASKRVAEYAFQYAKNnnrKKVTVV--HKANIMRMSDGLFLRCVRDM-----AQKFPE--IQFEEKYLDTVCLNMVQN 235
Cdd:PTZ00435 186 TDESIEGFARSCFQYALD---RKMPLYlsTKNTILKKYDGRFKDIFQEIydeeyKAKFEKagLWYEHRLIDDMVAQAIKS 262
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268  236 PGKYdVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNGALFES--VHGT------APDIAGKDLANPTALLLSAVMML 307
Cdd:PTZ00435 263 EGGF-VWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTVEAeaAHGTvtrhyrQHQKGKETSTNSIASIFAWTRGL 341
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 24643268  308 RHM-------ELNTYADKIERAAFETIKEGkYLTGDL 337
Cdd:PTZ00435 342 AHRakldnnqELVKFCQALERSCIETIEAG-FMTKDL 377
PdxA COG1995
4-hydroxy-L-threonine phosphate dehydrogenase PdxA [Coenzyme transport and metabolism]; ...
280-309 5.11e-03

4-hydroxy-L-threonine phosphate dehydrogenase PdxA [Coenzyme transport and metabolism]; 4-hydroxy-L-threonine phosphate dehydrogenase PdxA is part of the Pathway/BioSystem: Pyridoxal phosphate biosynthesis


Pssm-ID: 441598  Cd Length: 330  Bit Score: 38.51  E-value: 5.11e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 24643268 280 SV-HGTAPDIAGKDLANPTAL---LLSAVMMLRH 309
Cdd:COG1995 295 SVdHGTAFDIAGKGIADPGSLiaaIRLAARLARN 328
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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