|
Name |
Accession |
Description |
Interval |
E-value |
| mito_nad_idh |
TIGR00175 |
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ... |
23-354 |
0e+00 |
|
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]
Pssm-ID: 272942 Cd Length: 333 Bit Score: 526.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 23 GTKKVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDVTPVRgpDGKFGIPQAAIDSVNTNKIGLKGPLMTPVGKG-HR 101
Cdd:TIGR00175 2 GKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQT--DGKTEIPDEAVESIKRNKVALKGPLETPIGKGgHR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 102 SLNLALRKEFNLYANVRPCRSLEGYKTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASKRVAEYAFQYAK 181
Cdd:TIGR00175 80 SLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYAR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 182 NNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCAGLVG 261
Cdd:TIGR00175 160 KNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 262 GLGLTPSGNMGLNGALFE-SVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEGKYLTGDLGGR 340
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEpGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGT 319
|
330
....*....|....
gi 24643268 341 AKCSEFTNEICAKL 354
Cdd:TIGR00175 320 ATTSDFTEAVIKRL 333
|
|
| PLN00118 |
PLN00118 |
isocitrate dehydrogenase (NAD+) |
11-354 |
0e+00 |
|
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215062 Cd Length: 372 Bit Score: 509.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 11 NATPAASRSYSSGTK--KVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDVTPVRGPDGKFGIPQAAIDSVNTNKIGL 88
Cdd:PLN00118 26 GAFSSSARAFSSSSTpiTATLFPGDGIGPEIAESVKQVFTAAGVPIEWEEHYVGTTVDPRTGSFLTWESLESVRRNKVGL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 89 KGPLMTPVGKGHRSLNLALRKEFNLYANVRPCRSLEGYKTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEA 168
Cdd:PLN00118 106 KGPMATPIGKGHRSLNLTLRKELGLYANVRPCYSLPGYKTRYDDVDLVTIRENTEGEYSGLEHQVVRGVVESLKIITRQA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 169 SKRVAEYAFQYAKNNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLY 248
Cdd:PLN00118 186 SLRVAEYAFHYAKTHGRKRVSAIHKANIMKKTDGLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVLVMPNLY 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 249 GDILSDMCAGLVGGLGLTPSGNMGLNG-ALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETI 327
Cdd:PLN00118 266 GDIISDLCAGLIGGLGLTPSCNIGENGlALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRHLKLNEQAEQIHNAILNTI 345
|
330 340
....*....|....*....|....*..
gi 24643268 328 KEGKYLTGDLGGRAKCSEFTNEICAKL 354
Cdd:PLN00118 346 AEGKYRTADLGGSSTTTDFTKAICDHL 372
|
|
| LeuB |
COG0473 |
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ... |
24-354 |
8.25e-157 |
|
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440241 Cd Length: 346 Bit Score: 443.30 E-value: 8.25e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 24 TKKVTLIPGDGIGPEISAAVQKIFTAA----NVPIEWEAVDVtpvrgpdG-----KFG--IPQAAIDSVNTNKIGLKGPL 92
Cdd:COG0473 1 TYKIAVLPGDGIGPEVVAAALKVLEAAaerfGLDFEFEEADI-------GgaaydKTGtpLPDETLEALRKADAILLGAV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 93 MTPV---GKGHRSLNLALRKEFNLYANVRPCRSLEGYKTLY-----DDVDVVTIRENTEGEYSGIEHEIVDG----VVQS 160
Cdd:COG0473 74 GGPKwddGVRPESGLLALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAID 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 161 IKLITEEASKRVAEYAFQYAKNNnRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYD 240
Cdd:COG0473 154 TRVYTRKGIERIARYAFELARKR-RKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 241 VLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNG-ALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKI 319
Cdd:COG0473 233 VIVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHLGEEEAADAI 312
|
330 340 350
....*....|....*....|....*....|....*
gi 24643268 320 ERAAFETIKEGkYLTGDLGGRAKCSEFTNEICAKL 354
Cdd:COG0473 313 EAAVEKVLAEG-VRTPDLGGKAGTSEMGDAIIAAL 346
|
|
| Iso_dh |
pfam00180 |
Isocitrate/isopropylmalate dehydrogenase; |
26-350 |
4.49e-135 |
|
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507 Cd Length: 346 Bit Score: 388.58 E-value: 4.49e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 26 KVTLIPGDGIGPEISAAVQKIFTAAN----VPIEWEAVDVTPVRGPDGKFGIPQAAIDSVNTNKIGLKGPLMTPVG--KG 99
Cdd:pfam00180 1 KIAVLPGDGIGPEVMAAALKVLKAALekapLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWdpAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 100 HRSLN--LALRKEFNLYANVRPCRSLEG------YKTLYDDVDVVTIRENTEGEYSGIEHEIVDG---VVQSIKLITEEA 168
Cdd:pfam00180 81 VRPENglLALRKELGLFANLRPAKVFPPlgdaspLKNEVEGVDIVIVRELTGGIYFGIEKGIKGSgneVAVDTKLYSRDE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 169 SKRVAEYAFQYAKNNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLY 248
Cdd:pfam00180 161 IERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 249 GDILSDMCAGLVGGLGLTPSGNMGLNG-ALFESVHGTAPDIAGKDLANPTALLLSAVMMLRH-MELNTYADKIERAAFET 326
Cdd:pfam00180 241 GDILSDEASMLTGSLGLLPSASLGANGfGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLKV 320
|
330 340
....*....|....*....|....*..
gi 24643268 327 IKEGkYLTGDLGGRA---KCSEFTNEI 350
Cdd:pfam00180 321 LESG-IRTGDLAGSAtyvSTSEFGEAV 346
|
|
| PRK09222 |
PRK09222 |
NADP-dependent isocitrate dehydrogenase; |
25-354 |
1.70e-134 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236416 [Multi-domain] Cd Length: 482 Bit Score: 391.95 E-value: 1.70e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 25 KKVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDVTP---VRGPDGkfGIPQAAIDSVNTNKIGLKGPLMTPVGKGHR 101
Cdd:PRK09222 5 TPITVAYGDGIGPEIMEAVLKILEAAGAPLEIETIEIGEkvyKKGWTS--GISPSAWESIRRTKVLLKAPITTPQGGGYK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 102 SLNLALRKEFNLYANVRPCRSLEGY-KTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASKRVAEYAFQYA 180
Cdd:PRK09222 83 SLNVTLRKTLGLYANVRPCVSYHPFvETKHPNLDVVIIRENEEDLYAGIEHRQTPDVYQCLKLISRPGSEKIIRYAFEYA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 181 KNNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCAGLV 260
Cdd:PRK09222 163 RANGRKKVTCLTKDNIMKLTDGLFHKVFDEIAKEYPDIEAEHYIVDIGAARLATNPENFDVIVTPNLYGDILSDIAAEIS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 261 GGLGLTPSGNMGLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEGkYLTGDLGGR 340
Cdd:PRK09222 243 GSVGLAGSANIGEEYAMFEAVHGSAPDIAGKNIANPSGLLNAAVMMLVHIGQFDIAELIENAWLKTLEDG-IHTADIYNE 321
|
330 340
....*....|....*....|
gi 24643268 341 AKCS------EFTNEICAKL 354
Cdd:PRK09222 322 GVSKkkvgtkEFAEAVIENL 341
|
|
| PRK08997 |
PRK08997 |
isocitrate dehydrogenase; Provisional |
24-354 |
2.33e-134 |
|
isocitrate dehydrogenase; Provisional
Pssm-ID: 181606 Cd Length: 334 Bit Score: 386.00 E-value: 2.33e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 24 TKKVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDVTPVRGPDGKFGIPQAAIDSVNTNKIGLKGPLMTPVGKGHRSL 103
Cdd:PRK08997 2 KQTITVIPGDGIGPSIIDATLKILDKLGCDFEYEFADAGLTALEKHGELLPQRTLDLIEKNKIALKGPLTTPVGEGFTSI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 104 NLALRKEFNLYANVRPCRSLEGYKTLYDDVDVVTIRENTEGEYSGIEHEIV-DG-VVQSIKLITEEASKRVAEYAFQYAK 181
Cdd:PRK08997 82 NVTLRKKFDLYANVRPVLSFPGTKARYDNIDIITVRENTEGMYSGEGQTVSeDGeTAEATSIITRKGAERIVRFAYELAR 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 182 NNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCAGLVG 261
Cdd:PRK08997 162 KEGRKKVTAVHKANIMKSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDLCAGLVG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 262 GLGLTPSGNMGLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEGKYLTGDLGGRA 341
Cdd:PRK08997 242 GLGMAPGANIGRDAAIFEAVHGSAPDIAGKNLANPTSVILAAIQMLEYLGMPDKAERIRKAIVAVIEAGDRTTRDLGGTH 321
|
330
....*....|...
gi 24643268 342 KCSEFTNEICAKL 354
Cdd:PRK08997 322 GTTDFTQAVIDRL 334
|
|
| PLN00123 |
PLN00123 |
isocitrate dehydrogenase (NAD+) |
27-354 |
1.78e-126 |
|
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215065 Cd Length: 360 Bit Score: 367.27 E-value: 1.78e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 27 VTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDVTpvrgpDGKFGIPQAAIDSVNTNKIGLKGPLMTPVGKGHRSLNLA 106
Cdd:PLN00123 33 VTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERYEVH-----GDMKKVPEEVLESIRRNKVCLKGGLATPVGGGVSSLNVQ 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 107 LRKEFNLYANVRPCRSLEGYKTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASKRVAEYAFQYAKNNNRK 186
Cdd:PLN00123 108 LRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAYLNNRK 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 187 KVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCAGLVGGLGLT 266
Cdd:PLN00123 188 KVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANTAAGIAGGTGVM 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 267 PSGNMGLNGALFESVHGTA----PDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEGKYLTGDLGGRAK 342
Cdd:PLN00123 268 PGGNVGADHAVFEQGASAGnvgnEKLVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGKYRTKDLGGSST 347
|
330
....*....|..
gi 24643268 343 CSEFTNEICAKL 354
Cdd:PLN00123 348 TQEVVDAVIANL 359
|
|
| AksF2_Meth |
NF040626 |
homoisocitrate dehydrogenase; |
25-354 |
4.64e-113 |
|
homoisocitrate dehydrogenase;
Pssm-ID: 468598 Cd Length: 332 Bit Score: 332.08 E-value: 4.64e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 25 KKVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDVTpvRGPDGKFG--IPQAAIDSVNTNKIGLKGPLMTPvgKGHRS 102
Cdd:NF040626 2 YKITVIPGDGIGKEVMEAALYVLDALDLNFDFIEAEAG--RECFKKNGttIPEETIKIAKKSDATLFGAVTST--PGQKS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 103 LNLALRKEFNLYANVRPCRSLEGYKTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASKRVAEYAFQYAKN 182
Cdd:NF040626 78 PIITLRKELDLYANLRPIKSYEGINCLFKDLDFLIVRENTEGLYSGLEEEYTEEKAIAERVITRKASERICKFAFEYAIK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 183 NNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCAGLVGG 262
Cdd:NF040626 158 LGRKKVTAVHKANVLKKTDGIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVIVTTNLFGDILSDEAAGLVGG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 263 LGLTPSGNMGLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEGKYLTGDLGGRAK 342
Cdd:NF040626 238 LGLAPSANIGDKNGLFEPVHGSAPDIAGKNIANPIAMILSASMMLDYLGETYEANKLENALEKVLREGKVVTPDLGGNAK 317
|
330
....*....|..
gi 24643268 343 CSEFTNEICAKL 354
Cdd:NF040626 318 TMEMANEIKKKI 329
|
|
| PRK14025 |
PRK14025 |
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional |
25-354 |
9.50e-108 |
|
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
Pssm-ID: 184462 Cd Length: 330 Bit Score: 318.23 E-value: 9.50e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 25 KKVTLIPGDGIGPEISAAVQKIFTAANVPIEW---EAVDVTPVRgpDGKfGIPQAAIDSVNTNKIGLKGPlmtpVGKGHR 101
Cdd:PRK14025 2 HKICVIEGDGIGKEVVPAALHVLEATGLPFEFvyaEAGDEVFEK--TGK-ALPEETIEAAKEADAVLFGA----AGETAA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 102 SLNLALRKEFNLYANVRPCRSLEGYKTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASKRVAEYAFQYAK 181
Cdd:PRK14025 75 DVIVKLRRILDTYANVRPVKSYKGVKCLYPDIDYVIVRENTEGLYKGIEAEIADGVTVATRVITRKASERIFRFAFEMAK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 182 N----NNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCA 257
Cdd:PRK14025 155 RrkkmGKEGKVTCAHKANVLKKTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFGDILSDGAA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 258 GLVGGLGLTPSGNMGLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEGKyLTGDL 337
Cdd:PRK14025 235 GLVGGLGLAPSANIGDKYGLFEPVHGSAPDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEEVLALGL-TTPDL 313
|
330
....*....|....*..
gi 24643268 338 GGRAKCSEFTNEICAKL 354
Cdd:PRK14025 314 GGNLSTMEMAEEVAKRV 330
|
|
| LEU3_arch |
TIGR02088 |
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ... |
27-350 |
3.90e-107 |
|
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.
Pssm-ID: 273962 Cd Length: 322 Bit Score: 316.71 E-value: 3.90e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 27 VTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDVTPVRGPDGKFGIPQAAIDSVNTNKIGLKGPLMTPVGKGHRSLNLA 106
Cdd:TIGR02088 1 VAVIPGDGIGPEVIEAAIRILNKLGLEIEFIEFEAGDEALKKYGSALPEDTLEEIRKADAILFGAVTTPANPGYKSVIVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 107 LRKEFNLYANVRPCRSLEGYKTLY-DDVDVVTIRENTEGEYSGIEhEIVDGVVQSIKLITEEASKRVAEYAFQYAKNNNR 185
Cdd:TIGR02088 81 LRKELDLYANVRPAKSLPGIPDLYpNGKDIVIVRENTEGLYAGFE-FGFSDRAIAIRVITREGSERIARFAFNLAKERNR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 186 KkVTVVHKANIMRMSDGLFLRCVRDMAQKFpEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCAGLVGGLGL 265
Cdd:TIGR02088 160 K-VTCVHKANVLKGTDGLFREVCREIAKRY-GVEYRDMYVDSAAMNLVKDPWRFDVIVTTNMFGDILSDLASALAGSLGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 266 TPSGNMGLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEGkYLTGDLGGRAKCSE 345
Cdd:TIGR02088 238 APSANIGDRKALFEPVHGSAPDIAGKGIANPTAAILSVAMMLDYLGELEKGKLVWEAVEYYIIEG-KKTPDLGGTAKTKE 316
|
....*
gi 24643268 346 FTNEI 350
Cdd:TIGR02088 317 VGDEI 321
|
|
| ICDH_alpha |
TIGR02924 |
isocitrate dehydrogenase; This family of mainly alphaproteobacterial enzymes is a member of ... |
26-354 |
4.15e-107 |
|
isocitrate dehydrogenase; This family of mainly alphaproteobacterial enzymes is a member of the isocitrate/isopropylmalate dehydrogenase superfamily described by pfam00180. Every member of the seed of this model appears to have a TCA cycle lacking only a determined isocitrate dehydrogenase. The precise identity of the cofactor (NADH -- 1.1.1.41 vs. NADPH -- 1.1.1.42) is unclear. [Energy metabolism, TCA cycle]
Pssm-ID: 274353 [Multi-domain] Cd Length: 473 Bit Score: 321.71 E-value: 4.15e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 26 KVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDV-TPVRGPDGKFGIPQAAIDSVNTNKIGLKGPLMTPVGKGHRSLN 104
Cdd:TIGR02924 2 PITVAYGDGIGPEIMEAVLLILKEAEAPIDIETIEIgEKVYKKGWPSGISPSSWESIRRTKVLLKAPITTPQGGGHKSLN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 105 LALRKEFNLYANVRPCRSLEGY-KTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASKRVAEYAFQYAKNN 183
Cdd:TIGR02924 82 VTLRKTLGLYANIRPCVSYHPFiETKSPNLNIVIVRENEEDLYTGIEYRQTPDTYECTKLITRSGSEKICRYAFEYARKH 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 184 NRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCAGLVGGL 263
Cdd:TIGR02924 162 NRKKVTCLTKDNIMKMTDGIFHKIFDKIAAEYPDIESEHYIVDIGMARLATNPENFDVIVTPNLYGDILSDVAAEISGSV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 264 GLTPSGNMGLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEGKYlTGDL------ 337
Cdd:TIGR02924 242 GLAGSANIGEEYAMFEAVHGSAPDIAGQNIANPSGLLNAAIQMLVHIGQSDIAQLIYNAWLKTLEDGVH-TADIynekts 320
|
330
....*....|....*..
gi 24643268 338 GGRAKCSEFTNEICAKL 354
Cdd:TIGR02924 321 KQKVGTKEFAEAVTANL 337
|
|
| Icd |
COG0538 |
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ... |
30-354 |
2.86e-92 |
|
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304 Cd Length: 409 Bit Score: 281.61 E-value: 2.86e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 30 IPGDGIGPEISAAVQKIFTAA-------NVPIEWEAVDVtpvrgpdG-----KFG--IPQAAIDSVNTNKIGLKGPLMTP 95
Cdd:COG0538 24 IEGDGIGPEITRAIWKVIDAAvekayggKRDIEWKEVDA-------GekardETGdwLPDETAEAIKEYGVGIKGPLTTP 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 96 VGKGHRSLNLALRKEFNLYANVRPCRSLEGYKTL---YDDVDVVTIRENTEGEYSGIE--------------------HE 152
Cdd:COG0538 97 VGGGWRSLNVTIRQILDLYVCRRPVRYFKGVPSPvkhPEKVDIVIFRENTEDIYAGIEwkagspealkliffledemgVT 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 153 IVD-----GVVqsIKLITEEASKRVAEYAFQYAKNNNRKKVTVVHKANIMRMSDGLFlrcvRDMAQKFPEIQFEEK---- 223
Cdd:COG0538 177 VIRfpedsGIG--IKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAF----KDWGYEVAEEEFGDKfite 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 224 ----------------YLDTVCLNMVQN----PGKYDVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNG-ALFESVH 282
Cdd:COG0538 251 gpwekykgpkpagkivYKDRIADDMLQQillrPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGDDGgAEFEATH 330
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24643268 283 GTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIkEGKYLTGDL-----GGRA-KCSEFTNEICAKL 354
Cdd:COG0538 331 GTAPKYAGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTI-ESGKVTYDLarlmeGATElSTSEFGDAIIENL 407
|
|
| AksF_Meth |
NF040619 |
homoisocitrate dehydrogenase; |
26-350 |
5.43e-86 |
|
homoisocitrate dehydrogenase;
Pssm-ID: 468591 Cd Length: 332 Bit Score: 262.77 E-value: 5.43e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 26 KVTLIPGDGIGPEISAAVQKIFTaanvpiewEAVDVTPVRGPDG-----KFG--IPQAAIDSVNTNKIGLKGPLMTP--- 95
Cdd:NF040619 3 KICVIEGDGIGKEVIPETVRVLK--------ELGDFEFIKGEAGlecfkKYGdaIPEETIEKAKECDAILFGAVTTPkpt 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 96 --VGKGHRSLNLALRKEFNLYANVRPCRSLeGYKTLYDDVDVVTIRENTEGEYSGIE-HEIVDGVVQSIKLITEEASKRV 172
Cdd:NF040619 75 elKNKNYKSPILTLRKELDLYANVRPINNF-GDGQDVKNIDFVIIRENTEGLYVGREyYDEENEIAIAERIISKKGSERI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 173 AEYAFQYAKNNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPE--IQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGD 250
Cdd:NF040619 154 IKFAFEYAKKNNRKKVSCIHKANVLRVTDGLFLEIFNEIKKKYKNfnIEADDYLVDATAMYLIKNPEMFDVIVTTNLFGD 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 251 ILSDMCAGLVGGLGLTPSGNMGLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIeRAAFETIKEG 330
Cdd:NF040619 234 ILSDEASGLIGGLGLAPSANIGDKKGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDYLGMKEKGDLI-REAVKKCLEN 312
|
330 340
....*....|....*....|
gi 24643268 331 KYLTGDLGGRAKCSEFTNEI 350
Cdd:NF040619 313 GKVTPDLGGNLKTKEVTDKI 332
|
|
| PRK00772 |
PRK00772 |
3-isopropylmalate dehydrogenase; Provisional |
24-354 |
6.59e-83 |
|
3-isopropylmalate dehydrogenase; Provisional
Pssm-ID: 234832 Cd Length: 358 Bit Score: 255.80 E-value: 6.59e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 24 TKKVTLIPGDGIGPEISAAVQKIFTAA----NVPIEWE-------AVDVTPVRGPDGKFGIPQAAiDSVntnkiglkgpL 92
Cdd:PRK00772 2 TYKIAVLPGDGIGPEVMAEAVKVLDAVaekfGFDFEFEealvggaAIDAHGVPLPEETLEACRAA-DAV----------L 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 93 MTPVG-----------KGHRSLnLALRKEFNLYANVRPCR---SLEGYKTLYDDV----DVVTIRENTEGEYSG----IE 150
Cdd:PRK00772 71 LGAVGgpkwdnlppdvRPERGL-LALRKELGLFANLRPAKlypGLADASPLKPEIvaglDILIVRELTGGIYFGeprgRE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 151 HEIVDGVVQSIKLITEEASKRVAEYAFQYAKNNnRKKVTVVHKANIMRmSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCL 230
Cdd:PRK00772 150 GLGGEERAFDTMVYTREEIERIARVAFELARKR-RKKVTSVDKANVLE-SSRLWREVVTEVAKEYPDVELSHMYVDNAAM 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 231 NMVQNPGKYDVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNG-ALFESVHGTAPDIAGKDLANPTALLLSAVMMLRH 309
Cdd:PRK00772 228 QLVRNPKQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLGESGpGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRY 307
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 24643268 310 -MELNTYADKIERAAFETIKEGkYLTGDL---GGRAKCSEFTNEICAKL 354
Cdd:PRK00772 308 sLGLEEAADAIEAAVEKVLAQG-YRTADIaegGGKVSTSEMGDAILAAL 355
|
|
| PRK07006 |
PRK07006 |
isocitrate dehydrogenase; Reviewed |
30-350 |
1.53e-75 |
|
isocitrate dehydrogenase; Reviewed
Pssm-ID: 180792 Cd Length: 409 Bit Score: 238.81 E-value: 1.53e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 30 IPGDGIGPEISAAVQKIFTAA-------NVPIEWEAV----DVTPVRGPDgkFGIPQAAIDSVNTNKIGLKGPLMTPVGK 98
Cdd:PRK07006 25 IEGDGIGPDITPAMLKVVDAAvekaykgERKISWMEIyageKATKVYGED--VWLPEETLDLIREYRVAIKGPLTTPVGG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 99 GHRSLNLALRKEFNLYANVRPCRSLEGYKTLY---DDVDVVTIRENTEGEYSGIEHEI----VDGVVQ------------ 159
Cdd:PRK07006 103 GIRSLNVALRQELDLYVCLRPVRYFKGVPSPVkrpEDTDMVIFRENSEDIYAGIEWKAgsaeAKKVIKflqeemgvkkir 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 160 -------SIKLITEEASKRVAEYAFQYAKNNNRKKVTVVHKANIMRMSDGLFlrcvRDMAQKFPEIQFEEKYLDTVCLNM 232
Cdd:PRK07006 183 fpetsgiGIKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAF----KDWGYQLAEEEFGDELIDGGPWDK 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 233 VQN------------------------PGKYDVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNGALFESVHGTAPDI 288
Cdd:PRK07006 259 IKNpetgkeiivkdsiadaflqqillrPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANINDGHAIFEATHGTAPKY 338
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24643268 289 AGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEgKYLTGDL------GGRAKCSEFTNEI 350
Cdd:PRK07006 339 AGLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTIAS-KTVTYDFarlmegATEVKCSEFGDAL 405
|
|
| PRK03437 |
PRK03437 |
3-isopropylmalate dehydrogenase; Provisional |
21-350 |
3.46e-69 |
|
3-isopropylmalate dehydrogenase; Provisional
Pssm-ID: 179579 Cd Length: 344 Bit Score: 220.18 E-value: 3.46e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 21 SSGTKKVTLIPGDGIGPEISAAVQKIFTAAnvpieweAVDVTPVRGPDGKFG----------IPQAAIDSVNTNK---IG 87
Cdd:PRK03437 1 MAKTMKLAVIPGDGIGPEVVAEALKVLDAV-------AAGGPGVETTEYDLGarrylrtgetLPDSVLAELRQHDailLG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 88 LKGPLMTPVGKGHRSLNLALRKEFNLYANVRPCRSLEGYKT-LYD--DVDVVTIRENTEGEYSGI--------EHEIVDG 156
Cdd:PRK03437 74 AIGDPSVPSGVLERGLLLKLRFALDHYVNLRPSKLYPGVTSpLAGpgDIDFVVVREGTEGPYTGNggalrvgtPHEVATE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 157 VvqSIKliTEEASKRVAEYAFQYAKNNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNP 236
Cdd:PRK03437 154 V--SVN--TAFGVERVVRDAFERAQKRPRKHLTLVHKTNVLTFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTDP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 237 GKYDVLVMPNLYGDILSDMCAGLVGGLGLTPSGNM---GLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELN 313
Cdd:PRK03437 230 SRFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNInptGTNPSMFEPVHGSAPDIAGQGIADPTAAILSVALLLDHLGEE 309
|
330 340 350
....*....|....*....|....*....|....*..
gi 24643268 314 TYADKIERAafetikegkyLTGDLGGRAKCSEFTNEI 350
Cdd:PRK03437 310 DAAARIEAA----------VEADLAERGKMGRSTAEV 336
|
|
| leuB |
TIGR00169 |
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ... |
26-350 |
1.11e-68 |
|
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 272939 Cd Length: 346 Bit Score: 218.81 E-value: 1.11e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 26 KVTLIPGDGIGPEISAAVQKI-----------FTAANVPIEWEAVDVTPVRGPDGKFGIPQAAiDSVNTNKIGlkGPLMT 94
Cdd:TIGR00169 1 KIAVLPGDGIGPEVMAQALKVlkavaerfglkFEFEEHLIGGAAIDATGQPLPEETLKGCKEA-DAVLLGAVG--GPKWD 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 95 PVGKGHRSLN--LALRKEFNLYANVRPCR---SLEGYKTLYDD----VDVVTIRENTEGEYSGIEHEI-VDGVVQSIKLI 164
Cdd:TIGR00169 78 NLPRDQRPEQglLKLRKSLDLFANLRPAKvfpGLEDLSPLKEEiakgVDFVVVRELTGGIYFGEPKGReGEGEAWDTEVY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 165 TEEASKRVAEYAFQYAKNNnRKKVTVVHKANIMRMSDgLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVM 244
Cdd:TIGR00169 158 TVPEIERIARVAFEMARKR-RKKVTSVDKANVLESSR-LWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVT 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 245 PNLYGDILSDMCAGLVGGLGLTPSGNMGLNG-ALFESVHGTAPDIAGKDLANPTALLLSAVMMLRH-MELNTYADKIERA 322
Cdd:TIGR00169 236 SNLFGDILSDEASVITGSLGMLPSASLGSDGfGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYsFNLEEAADAIEAA 315
|
330 340
....*....|....*....|....*...
gi 24643268 323 AFETIKEGKYlTGDLGGRAKCSEFTNEI 350
Cdd:TIGR00169 316 VKKVLAEGYR-TPDLGSSATTAVGTAEM 342
|
|
| TTC |
TIGR02089 |
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ... |
26-354 |
4.84e-68 |
|
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]
Pssm-ID: 273963 Cd Length: 352 Bit Score: 217.39 E-value: 4.84e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 26 KVTLIPGDGIGPEISAAVQKIFTAA------------NVPIEWEAVDVTPVRGP-DGKFGIPQaaIDSVNTNKIGlkGPL 92
Cdd:TIGR02089 5 RIAAIPGDGIGKEVVAAALQVLEAAakrhggfslhftEFPWSCDYYKEHGKMMPeDGLEKLKK--FDAIFLGAVG--WPA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 93 MTPVGKGHRSLNLALRKEFNLYANVRPCRSLEGYKT-----LYDDVDVVTIRENTEGEYSGIEHEIVDG----VVQSIKL 163
Cdd:TIGR02089 81 LVPDHISLWGLLLKIRREFDQYANVRPAKLLPGVTSplrncGPGDFDFVVVRENSEGEYSGVGGRIHRGtdeeVATQNAI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 164 ITEEASKRVAEYAFQYAKNNnRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLV 243
Cdd:TIGR02089 161 FTRKGVERIMRFAFELAQKR-RKHLTSATKSNGIRHSMPFWDEVFAEVAAEYPDVEWDSYHIDALAARFVLKPETFDVIV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 244 MPNLYGDILSDMCAGLVGGLGLTPSGNMGLNG---ALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKIe 320
Cdd:TIGR02089 240 ASNLFGDILSDLGAALMGSLGVAPSANINPEGkfpSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEHLGEKEAGAKI- 318
|
330 340 350
....*....|....*....|....*....|....
gi 24643268 321 RAAFETIKEGKYLTGDLGGRAKCSEFTNEICAKL 354
Cdd:TIGR02089 319 MDAIERVTAAGILTPDVGGKATTSEVTEAVCNAL 352
|
|
| PRK06451 |
PRK06451 |
NADP-dependent isocitrate dehydrogenase; |
25-337 |
4.15e-67 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 235803 Cd Length: 412 Bit Score: 217.01 E-value: 4.15e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 25 KKVTL-IPGDGIGPEISAAVQKIFTAA-------NVPIEWeaVDVTPVRGPDGKFG--IPQAAIDSVNTNKIGLKGPLMT 94
Cdd:PRK06451 23 KPIILyVEGDGIGPEITHAAMKVINKAvekaygsDREIKW--VEVLAGDKAEKLTGnrFPKESEELIEKYRVLLKGPLET 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 95 PVGKGHRSLNLALRKEFNLYANVRPCRSLEGYKTLY---DDVDVVTIRENTEGEYSGIEH-------------------- 151
Cdd:PRK06451 101 PIGKGWKSINVAIRLMLDLYANIRPVKYIPGIESPLknpEKIDLIIFRENTDDLYRGIEYpydseeakkirdflrkelgv 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 152 EIVDGVVQSIKLITEEASKRVAEYAFQYAKNNNRKKVTVVHKANIMRMSDGLF--------LRCVRD-------MAQKFP 216
Cdd:PRK06451 181 EVEDDTGIGIKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFrewayevaLKEFRDyvvteeeVTKNYN 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 217 EIQFEEKYL--DTVCLNMVQN----PGKYDVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNGALFESVHGTAPDIAG 290
Cdd:PRK06451 261 GVPPSGKVIinDRIADNMFQQiiirPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTGGMFEAIHGTAPKYAG 340
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 24643268 291 KDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEGKyLTGDL 337
Cdd:PRK06451 341 KNVANPTGIIKGGELMLRFMGWDKAADLIDKAIMESIKQKK-VTQDL 386
|
|
| PRK08194 |
PRK08194 |
tartrate dehydrogenase; Provisional |
26-354 |
1.73e-61 |
|
tartrate dehydrogenase; Provisional
Pssm-ID: 181281 Cd Length: 352 Bit Score: 200.72 E-value: 1.73e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 26 KVTLIPGDGIGPEISAAVQKIFTAAN----------VPIEW------EAVDVTPvrgpdgKFGIPQ-AAIDSVNTNKIGl 88
Cdd:PRK08194 5 KIAVIPGDGVGKEVVPAAVRVLKAVAevhgglkfefTEFPWsceyylEHGEMMP------EDGLEQlKQFDAIFLGAVG- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 89 kGPLMTPvgkGHRSL---NLALRKEFNLYANVRPCRSLEGYKTLY---DDVDVVTIRENTEGEYSGI-------EHEIVd 155
Cdd:PRK08194 78 -NPKLVP---DHISLwglLIKIRREFEQVINIRPAKQLRGIKSPLanpKDFDLLVVRENSEGEYSEVggrihrgEDEIA- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 156 gvVQSiKLITEEASKRVAEYAFQYAKNNnRKKVTVVHKAN----IMRMSDGLFlrcvRDMAQKFPEIQFEEKYLDTVCLN 231
Cdd:PRK08194 153 --IQN-AVFTRKGTERAMRYAFELAAKR-RKHVTSATKSNgivhSMPFWDEVF----QEVGKDYPEIETDSQHIDALAAF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 232 MVQNPGKYDVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNG---ALFESVHGTAPDIAGKDLANPTALLLSAVMMLR 308
Cdd:PRK08194 225 FVTRPEEFDVIVASNLFGDILTDIGAAIMGSIGIAPAANINVNGkypSMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLD 304
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 24643268 309 HMELNTYADKIERAAFETIKEGkYLTGDLGGRAKCSEFTNEICAKL 354
Cdd:PRK08194 305 HFGEEELGSHLLDVIEDVTEDG-IKTPDIGGRATTDEVTDEIISRL 349
|
|
| PRK07362 |
PRK07362 |
NADP-dependent isocitrate dehydrogenase; |
27-350 |
1.85e-57 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 180944 Cd Length: 474 Bit Score: 193.39 E-value: 1.85e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 27 VTLIPGDGIGPEISAAVQKIFTAA-------NVPIEW-------EAVDVTpvrgpdGKFG-IPQAAIDSVNTNKIGLKGP 91
Cdd:PRK07362 31 IPFIRGDGTGVDIWPATQKVLDAAvakayggERKINWfkvyagdEACDLY------GTYQyLPEDTLEAIREYGVAIKGP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 92 LMTPVGKGHRSLNLALRKEFNLYANVRPCRSLEGYKTLY---DDVDVVTIRENTEGEYSGIEHEIVDGVVQS-------- 160
Cdd:PRK07362 105 LTTPIGGGIRSLNVALRQIFDLYSCVRPCRYYAGTPSPHknpEKLDVIVYRENTEDIYMGIEWEAGDEIGDKlikhlnee 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 161 --------------------IKLITEEASKRVAEYAFQYAK--NNNRKKVTVVHKANIMRMSDGLF-----------LR- 206
Cdd:PRK07362 185 vipaspelgkrqiplgsgigIKPVSKTGSQRHIRRAIEHALrlPGDKRHVTLVHKGNIMKYTEGAFrdwgyelatteFRd 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 207 -CVRDMA-------QKFPEIQFEE--------------------------------------KYLDTVCLN--------- 231
Cdd:PRK07362 265 eCVTEREswilsnkEKNPNISIEDnarmiepgydsltpekkaaicaevkevldsiwsshgngKWKEKVLVDdriadsifq 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 232 MVQN-PGKYDVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHM 310
Cdd:PRK07362 345 QIQTrPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAAIFEATHGTAPKHAGLDRINPGSVILSGVMMLEYL 424
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 24643268 311 ELNTYADKIERAAFETIKEGKyLTGDLG-------GRAKCSEFTNEI 350
Cdd:PRK07362 425 GWQEAADLITKGLSAAIANKQ-VTYDLArlmeppvDPLSCSEFAEAI 470
|
|
| PLN02329 |
PLN02329 |
3-isopropylmalate dehydrogenase |
27-337 |
2.83e-39 |
|
3-isopropylmalate dehydrogenase
Pssm-ID: 215188 Cd Length: 409 Bit Score: 143.67 E-value: 2.83e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 27 VTLIPGDGIGPEISAAVQKIFTAA-----------NVPIEWEAVDVTPVRGPDGKFgipqAAIDSVNTNKIGLKGPLMTP 95
Cdd:PLN02329 49 IALLPGDGIGPEVISVAKNVLQKAgsleglefdfqEMPVGGAALDLVGVPLPEETF----TAAKQSDAILLGAIGGYKWD 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 96 VGKGHRSLNLAL---RKEFNLYANVRPCRSLEGY-------KTLYDDVDVVTIRENTEGEYSGIEHEIV-----DGVVQS 160
Cdd:PLN02329 125 KNEKHLRPEMALfylRRDLKVFANLRPATVLPQLvdastlkKEVAEGVDMMIVRELTGGIYFGEPRGITinengEEVGVS 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 161 IKLITEEASKRVAEYAFQYAKNNnRKKVTVVHKANIMRMSDgLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYD 240
Cdd:PLN02329 205 TEIYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFD 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 241 VLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNG-ALFESVHGTAPDIAGKDLANPTALLLSAVMMLRH-MELNTYADK 318
Cdd:PLN02329 283 TIVTNNIFGDILSDEASMITGSIGMLPSASLGESGpGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAKR 362
|
330
....*....|....*....
gi 24643268 319 IERAAFETIKEGkYLTGDL 337
Cdd:PLN02329 363 IEDAVVDALNKG-FRTGDI 380
|
|
| PRK08299 |
PRK08299 |
NADP-dependent isocitrate dehydrogenase; |
149-337 |
1.56e-05 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236226 Cd Length: 402 Bit Score: 46.39 E-value: 1.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 149 IEHEIVD----GVVQSIKlITEEASKRVAEYAFQYAKNNNrKKVTVVHKANIMRMSDGLFlrcvRDMAQKFPEIQFEEKY 224
Cdd:PRK08299 164 IEHEVHDfpgaGVAMGMY-NLDESIRDFARASFNYGLDRK-YPVYLSTKNTILKAYDGRF----KDIFQEVYEAEFKEKF 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 225 -----------LDTVCLNMVQNPGKYdVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNGALFES--VHGTAPD---- 287
Cdd:PRK08299 238 eaagityehrlIDDMVASALKWEGGY-VWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKTVEAeaAHGTVTRhyrq 316
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 24643268 288 -IAGKDLA-NPTALLLSAVMMLRH-------MELNTYADKIERAAFETIKEGKyLTGDL 337
Cdd:PRK08299 317 hQKGEETStNPIASIFAWTRGLAHrgkldgnPELVKFADTLEKVCIETVESGF-MTKDL 374
|
|
| PLN03065 |
PLN03065 |
isocitrate dehydrogenase (NADP+); Provisional |
165-337 |
1.57e-05 |
|
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 178617 [Multi-domain] Cd Length: 483 Bit Score: 46.41 E-value: 1.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 165 TEEASKRVAEYAFQYAKNnnrKK--VTVVHKANIMRMSDGLFLRCVRDM-----AQKFPE--IQFEEKYLDTVCLNMVQN 235
Cdd:PLN03065 254 VDESIRAFAESSMAMALQ---KKwpLYLSTKNTILKKYDGRFKDIFQEVyeeqwKQKFEEhsIWYEHRLIDDMVAYAVKS 330
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 236 PGKYdVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNGALFES--VHGTAPD-----IAGKDLA-NPTALLLSAVMML 307
Cdd:PLN03065 331 EGGY-VWACKNYDGDVQSDLLAQGFGSLGLMTSVLLSSDGKTLEAeaAHGTVTRhfrlhQKGQETStNSIASIFAWTRGL 409
|
170 180 190
....*....|....*....|....*....|....*..
gi 24643268 308 RHM-------ELNTYADKIERAAFETIKEGKyLTGDL 337
Cdd:PLN03065 410 EHRakldkneELLDFVHKLESACIETVESGK-MTKDL 445
|
|
| PTZ00435 |
PTZ00435 |
isocitrate dehydrogenase; Provisional |
165-337 |
9.70e-05 |
|
isocitrate dehydrogenase; Provisional
Pssm-ID: 240417 Cd Length: 413 Bit Score: 43.82 E-value: 9.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 165 TEEASKRVAEYAFQYAKNnnrKKVTVV--HKANIMRMSDGLFLRCVRDM-----AQKFPE--IQFEEKYLDTVCLNMVQN 235
Cdd:PTZ00435 186 TDESIEGFARSCFQYALD---RKMPLYlsTKNTILKKYDGRFKDIFQEIydeeyKAKFEKagLWYEHRLIDDMVAQAIKS 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24643268 236 PGKYdVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNGALFES--VHGT------APDIAGKDLANPTALLLSAVMML 307
Cdd:PTZ00435 263 EGGF-VWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTVEAeaAHGTvtrhyrQHQKGKETSTNSIASIFAWTRGL 341
|
170 180 190
....*....|....*....|....*....|....*..
gi 24643268 308 RHM-------ELNTYADKIERAAFETIKEGkYLTGDL 337
Cdd:PTZ00435 342 AHRakldnnqELVKFCQALERSCIETIEAG-FMTKDL 377
|
|
| PdxA |
COG1995 |
4-hydroxy-L-threonine phosphate dehydrogenase PdxA [Coenzyme transport and metabolism]; ... |
280-309 |
5.11e-03 |
|
4-hydroxy-L-threonine phosphate dehydrogenase PdxA [Coenzyme transport and metabolism]; 4-hydroxy-L-threonine phosphate dehydrogenase PdxA is part of the Pathway/BioSystem: Pyridoxal phosphate biosynthesis
Pssm-ID: 441598 Cd Length: 330 Bit Score: 38.51 E-value: 5.11e-03
10 20 30
....*....|....*....|....*....|....
gi 24643268 280 SV-HGTAPDIAGKDLANPTAL---LLSAVMMLRH 309
Cdd:COG1995 295 SVdHGTAFDIAGKGIADPGSLiaaIRLAARLARN 328
|
|
|