X-ray repair cross complementing 2 [Drosophila melanogaster]
Protein Classification
P-loop NTPase family protein( domain architecture ID 1562424)
P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| P-loop_NTPase super family | cl38936 | P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ... |
21-178 | 8.12e-20 | ||||
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families. The actual alignment was detected with superfamily member cd19490: Pssm-ID: 476819 [Multi-domain] Cd Length: 226 Bit Score: 84.71 E-value: 8.12e-20
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| Name | Accession | Description | Interval | E-value | ||||
| XRCC2 | cd19490 | XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells ... |
21-178 | 8.12e-20 | ||||
XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells 2) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC2, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC3, helps recruit RAD51 to the break site. Pssm-ID: 410898 [Multi-domain] Cd Length: 226 Bit Score: 84.71 E-value: 8.12e-20
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| RepA | COG3598 | RecA-family ATPase [Replication, recombination and repair]; |
24-178 | 6.11e-04 | ||||
RecA-family ATPase [Replication, recombination and repair]; Pssm-ID: 442817 [Multi-domain] Cd Length: 313 Bit Score: 40.27 E-value: 6.11e-04
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| Name | Accession | Description | Interval | E-value | ||||
| XRCC2 | cd19490 | XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells ... |
21-178 | 8.12e-20 | ||||
XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells 2) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC2, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC3, helps recruit RAD51 to the break site. Pssm-ID: 410898 [Multi-domain] Cd Length: 226 Bit Score: 84.71 E-value: 8.12e-20
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| RepA | COG3598 | RecA-family ATPase [Replication, recombination and repair]; |
24-178 | 6.11e-04 | ||||
RecA-family ATPase [Replication, recombination and repair]; Pssm-ID: 442817 [Multi-domain] Cd Length: 313 Bit Score: 40.27 E-value: 6.11e-04
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| Blast search parameters | ||||
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